Practical 2 23 February 2011 Student no. 210508229 Student name: Ashmika Singh Hydrolysis of p-nitroacetanilide Aim: 1.

To conduct a hydrolysis of p-nitroacetanilide 2. To determine if the hydrolysis was effective by performing a TLC analysis of the hydrolysed p-nitroacetanilide and comparing it to isomers of nitroacetanilide Reaction mechanism:

Rf values: p-nitroaniline: Rf: Distance travelled by compound spot (mm) Distance travelled by solvent front (mm) 23.5/58.5 = 0.40 o-nitroaniline: Rf: Distance travelled by compound spot (mm) Distance travelled by solvent front (mm) 43.5/58.5 = 0.74

Traces of the o.1 difference in values.and mnitroaniline were also present suggesting that recrystallisation was not carried out correctly.5 = 0.5/58. . it can therefore be said that the p-isomer was produced in the reaction.m-nitroaniline: Rf: Distance travelled by compound spot (mm) Distance travelled by solvent front (mm) 32. it can be concluded that they are very similar in chemical composition hence the hydrolysis was effective.41 Conclusion: Since the Rf of the sample and the p-nitroacetanilide are within a 0.56 sample: p-nitroaniline: Rf: Distance travelled by compound spot (mm) Distance travelled by solvent front (mm) 24/58.5 = 0.

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