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39 Altered Cell Differentiation and Growth

HFD of cancer
(CA of liver) tumor in the ovary
High fat diet -germ cell ovary tumors staphylococcus, streptococcus,
Hx of dysmenorrheal -epithelial cell tumors coliform bacteria
High estrogen levels -sex cord stromal ovarian tumor
(granulosa cell tumor)
invasion to the lacerations
Stimulation of the growth of leiomyomas that occur during childbirth,
instrumentation or trauma
Enlargement of ovary

low grade inflammation

Wall of Bladder under rectum leiomyomas fluid accumulates compression
uterus lining without in the abdomen of stomach
of uterus symptoms (ascites) ducts of glands in distorted muco-
urinary cervix are blocked cervical purulent
frequency/ heavy by a new growth os drainage
urgency bleeding abdominal impaired loss of appetite of surface cells over
abnormal distention/ functioning damaged area
constipation presentation bloating of lower ulcerated
of baby esophageal cervix
miscarriage before sphincter malabsorption formation of sac
delivery diaphragm of Fe that contains
dysmenorhhea pushed thick fluid
upward acid, enzyme malabsorption
and gastric of vit. B12
content reflux nabothian cyst
pressure exerted
to the lungs
heartburn Hgb MCV MCH
(9.49 g/dl) (71.6 fl) (23.1 pg) untreated
alteration in the
permeability of
pleural membrane esophagitis affinity of RBC to 02
dysmenorrheal low back pain cervical
dyspnea accumulation of fluid
in the pleural cavity fatigue hypoxemia pallor pale pale pelvic cellulitis
SOB (pleural effusion) nailbeds palpebral
chest pain conjunctiva
inadequate tissue perfusion


dilation of arterioles, irritability, LOC, cyanosis, movement of fluid from

capillaries and venules seizures, coma interstitial to blood vessels
(compensatory mechanism) (compensatory mechanism) (compensatory mechanism)

expansion of blood volume

blood viscosity Hct (29.4 %)

faster and more turbulent blood flow

(compensatory mechanism)

uncontrolled BP

SGOT hepatic perfusion

pancreatic perfusion vasospasm
RUQ epigastric pain

hyperbilirubinemia renal perfusion


Permeability of glomerular BUN, serum creatinine Na retention oliguria remaining functional nephrons
membrane compensate by more filtration

large protein particles primarily

albumin move out of urine hypertrophy of functional nephrons

further damage of nephrons

serum albumin proteinuria

multi-system manifestations/uremic syndrome

plasma colloid osmotic pressure

movement of fluid from

intravascular to interstitial

immune disturbances loss of excretory renal function failure to produce erythropoietin

intravascular generalized edema
volume in lungs
further anemia
cerebral edema impair wound healing

pulmonary edema
(pleural effusion) CNS irritability
Na absorption H secretion phosphate excretion K excretion excretion of nitrogenous
impaired gas influx of excess Na in
exchange nausea vomiting convulsion urine (salt wasting) metabolic hyperphosphatemia hypokalemia
acidosis uremia

hypoatremia Ca absorption excitability of BUN, uric acid,

hypoxia heart muscles
ECF becomes hyposmolar parathyroid gland
release PTH heart muscles become pruritus
tissue necrosis weak, flaccid and
water rushes inside cell paralyzed
phosphate excretion
bleeding tendencies absorbs Ca from bones
fluid loss in ECF
DEATH cardiac arrest peripheral nerve
bone demineralization damage
circulating fluid in systemic circulation
O2 supply to tissue Neurologic changes
calcification of vital
hypovolemic shock organs
tissue necrosis

Coma peripheral

further exposure of brain

to nitrogenous wastes