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A GLIMPSE ON MCQ OF PHARMACOGNOSY

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TEST ON PHARMACOGNOSY Q1. Match the suitable diagnostic feature of alkaloidal drugs 1. 2. 3. 4. 5. 6. 7. 8. 9. Spindle shaped phloem fibers, with presence of lignified fibro vascular bundles. Epidermis with smooth cuticle, Anisocytic stomata and anomocytic stomata, glandular and non glandular. Rhombo idal calcium oxalate crystals Ranuculaceous stomata and no calcium oxalate crystals, unicellular covering trichomes Lignified trichomes, collapsed cells, no calcium oxalate crystals and starch grains. Sunken stomata and scaly leaves Leaves with rubiaceous stomata, no trichomes Cruciferous stomata, no calcium oxalate crystals, presence of warty trichomes Stratified cork, stone cells and phloem fibers are absent. c. Cinchona bark d. Nux-vomica seed e. Eucalyptus leaf

a. Kurchi bark b. Rauwolfia root f. Datura leaf g. Vinca

Q2. Match the suitable diagnostic feature for volatile oil containing drugs

Q3. Match the following biosynthetic precursors 1. Phenylalanine a. Reserpine 2. Tyrosine b. Atropine 3. Dopamine c. Quinine 4. Tryptophan d. Morphine 5. Ornithine e. Ephedrine 6. Lysine f. Lupine

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a. Anise b. Clove f. Coriander

c. Cinnamon

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1. Epidermis with unicellular conical thick walled warty trichomes, rosette calcium oxalate crystals and Reticulated parenchyma cells. 2. Acicular crystals with lignified pericyclic fibers embedded in sheath of stone cells, abundant starch grains. 3. Presence of transverse wrinkles or rugae , anatropous ovule, partially lignified fibro vascular bundles. 4. Epidermis with anomocytic stomata with cluster of calcium oxalate, ellipsoidal schizogenous glands and absence of starch grains. 5. Pericarp with Anomocytic stomata, mesocarp contains lignified reticulate parenchyma, rosette cryatals of calcium oxalate. 6. Coleospermic fruit, primary and secondary ridges in cremocarp and vitamin A in leaves.

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d. Cardamom

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e. Fennel

i. Opium leaf

j. Coca

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Q4. Match the following seeds outgrowth 1. Aril a. Colchicum 2. Arillode b. Strophanthus 3. Arista c. Cardamom 4. Strophile d. Nutmeg Q5. Match the following standard test for 1. Keller-Kiliani a. Tropane alkaloid s 2. Van-Urk’s b. Cinchona 3. Murexide c. Caffeine 4. Vitali-Morin d. Ergot alkaloids 5. Thalloquin e. Anthraquinone 6. Kluge’s f. Isobarbiloin 7. Dragendroff’s h. Alkaloids 8. Borntrager’s test i. Digitoxose Q6. Shikimic acid is a. 3,4,5-Trihydroxy benzoic acid b. 3,4,5-Trihydroxy hexenoic acid c. 3,4,5-Anthralinic acid d. 2,4-Dihydroxy-3-methyl valeric acid

Q7. Shikimic acid pathway is intermediate for all excluded

Q8. Mevalonic acid is

a. b. c. d.

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a. 3,5-Dihydroxy-3-methyl valeric acid b. 2,5-Dihydroxy-3-methyl valeric acid c. 2,4-Dihydroxy-2-methyl valeric acid d. 3,5-Dihydroxy-2-methyl valeric acid ] Q9. Anthranilic acid is used in biosynthesis of Phenylalanine Tyrosine Tryptophan Purine

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a. b. c. d.

Flavones Aromatic amino acids Coumarins Steroids

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Q10. Steroids are biosynthesized by a. b. c. d. Malonyl CoA Mevalonic acid Shikimic acid Tricarboxylic acid cycle

Q11. Isoprene unit is a. b. c. d. 2-methyl-1,3-butadiene 3-methyl-1,3-butadiene 2-methyl-2,4-butadiene 2-chloro-1,3-butadiene

Q12. HMG-COA is a. b. c. d. ß-hydroxy- ß-methyl glutaryl COA a-hydroxy- ß-methyl glutaryl COA ß-hydroxy- ß-methyl malonyl COA a-hydroxy- ß-methyl malonyl COA

Q13. Palthe Senna / C. Auriculata is differentiated from genuine Senna by

Q14. Maximum amount of barbaloin is present in a. b. c. d. Curacao aloe Cape aloe Socotrine aloe Zanzibar aloe

a. b. c. d.

Q16. Which of the following are test for Isobarbiloin?
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Q15. Which of the following test of aloe is based upon the florescence? Cupraloin test Bromin e test Borax test Schoen teten’s test

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a. b. c. d.

presence of obvate shape leaves absence of Anthraquinones glycosides presence of papillose cells in epidermis it is O-glycoside

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p. q. r. s. a.

Cupraloin test Nitrous acid Nitric acid Schoen teten’s test P,Q b. Q,R c. P,R d. P,S

Q17. Indian rhubarb is a. b. c. d. Rheum emodi R. Palmatum R. webbianum R. rhapnoticum

Q18. Which of the following is sesquiterpene? a. b. c. d. Foskolin Berberine Zingiberine Citral

Q19. Lysergic acid analogues are biosynthesized by a. b. c. d. Phenylalanine Tyrosine Tryptophan Lysine

Q20. Squalene has how many isoprene units? a. b. c. d. 2 3 4 5

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Q21. Which of the following is not a microscopic characteristic of Senna? a. b. c. d. Presence of thick walled warty trichomes Presence of rubiaceous stomata Presence of cluster sheath Presence of raphides

Q22. Identify the true statement about Senna? a. b. c. d. It have C-glycoside Will give modified Borntrager’s test Sennoside A is meso form and B is Trans form Sennoside C is trans form and D is meso form

Q23. Identify the false statement about rhubarb a. b. c. d.

Indian rhubarb does not contain rhaponiticin Rhaponiticin is diphenyl ethylene analogue having estrogenic activity Rhapnoticum rhubarb give blue florescence while Indian rhubarb give violet florescence Rhapnoticum rhubarb shows presence of rhein, emodin and aloe emodin.

Q24. Which of the following is not a test for digitalis?

Q25. Match the following how the different variety are differentiated from digitalis? 1. 2. 3. 4. Multi cellular trichomes forming Hook at top a. Comfrey leaves Presence of large wooly trichomes b. Verbascum Thapus Trichomes 8-9 celled long c. Primose leaves Presence of calcium oxalate crystals d. D.Thapsi

a. b. c. d.

Q27. Which of the lanatoside mainly give digoxin?
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Q26. Digoxin is cardenolide which is mainly used for rapid digitalization therapy have –OH grp at 14 14,16 12,14,16 12,16

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a. b. c. d.

Baljet test Legal test Modified Borntager’s test Keller-Kiliani test

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a. b. c. d.

A B C D

Q28. Which of the following is not a microscopic characteristic of digitalis? a. b. c. d. Presence of anomocytic stomata 3-5 celled long trichomes Collapsed celled covering trichomes Presence of calcium oxalate crystals

Q29. Carbenoloxone used as antiulcer is a derivative of a. b. c. d. Dioscorea Liquorice Ginseng Safed musali

Q30. Match the biological activity reported 1. 2. 3. 4. 5. 6. 7. 8. 9. Antioxytocic a. Shatavari Precursor for steroid synthesis b. Dioscorea Immunomodulator c. Ginseng Heaptoprotective d. Silymarin Calculous affections e. Gokhru Vascular disorders f. Ginkgo Capillary fragility g. BucK-Wheat Angina pectoris h. Visnaga Antidiabetic i. Gymnema

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Q31. Ophelic acid is present in a. b. c. d. Picrorrhiza Gentian Chirata Kalmegh

Q32. Match the following functional moiety present in volatile oil 1. 2. 3. 4. 5. 6. 7. Ester a. Gaultheria oil Ether b. Fennel Ketone c. Caraway Phenol d. Clove Oxide e. Chenopodium Alcohol f. Peppermint Aldehyde i. Lemon

Q33. Myrrh is a. b. c. d. Acid resin Ester acid Alcohol resin Carbohydrate

Q34. Wild cherry bark contains prunasin which is a

A) Phenolic glycoside (B) Isothiocyanate glycoside (C) Coumarin glycoside (D)Cyanogeneticglycoside Q35. Ephedra sinica and Ephedra equisetina can be distinguished by type of (A) Branching (B) Stomata (C) Scaly leaves (D) Alkaloids Q36. Acontitine belongs to the group of A) Steroidal alkaloids (B) Terpenoidal alkaloids (C) Indole alkaloids (D) Quinoline alkaloids

A) Soft tissue matter (B) Woody matter (C) Mineral matter (D) Organic matter Q38. Safranin is used as a reagent to detect (A) Gram-negative bacteria (B) Gram-positive bacteria Q39. Quercetin is

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Q37. Crude fiber value of a drug is a measure of

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(C) Acid fast bacteria (D) Myxozoa

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(A) 5, 7, 3-Trihydroxy flavones (B) 5, 7, 3, 4-Tetradydroxy flavones (C) 3, 5, 7, 3, 4-Pen tahydroxy flavonol (D) 3, 5, 7, 3, 4-Pentahydroxy flavonone Q40. A novel diterpenoid isolated from the bark of Taxus brevifolia is A) Demecolcine (B) Paclitaxel (C) Vinblastin (D)Brevifolicin Q41.Myristica fragrans Houtt has two of the following characteristics.

Q44. Group I Specific chemical test (P) Thalleioquin Test (Q) Murexide Test (R) Vitali-Morin Test (s) Modified Borntrager’sTest (A) P - 4 Q – 1 R – 3 S - 2 (C) P - 3 Q – 4 R – 2 S - 1 (B) P - 1 Q – 3 R – 4 S - 1 (D) P - 2 Q - 2 R – 3 S - 4

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Q43. Clove stalks can be identified by the presence of (A) Starch grains (B) Cystolith s (C) Lignified sclereids (D) Acicular crystals of calcium oxalate

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Q42. Group I Lanatosides Group II Aglycone (P) Lanatoside A (1) Gitaxigenin (Q) LanatosideB (2) Diginatigenin (R) Lanatoside C (3) Digoxigenin (S) Lanatoside D (4) Digitoxigenin (A) P - 1 Q - 2 R-3 S-4 (B) p - 3 Q - 1 R -2 S-4 (C) P - 2 Q – 4 R-3 S-1 (D) P - 3 Q -3 R - 1 S-4

Q45. Presence of one of the following characteristics show that the Rauwolfia serpentine is adulterated with other species of Rauwolfia.
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Group II Phytoconstituents (1) Hyoscyamine (2) Barbaloin (3) Quinine (4) Theobromine

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(P) An indeciduous tree, which produces drupaceous, pale yellow fruits. (Q) Each fruit has several round seeds with smooth surface and lignaceous tegument, and the orange red fleshy aril — the mace, is present inside the seed. (R) A deciduous tall tree, which produces lignaceous capsu les. (S) Each fruit has a unique avoid seed, with lignified tegument, surrounded by orange red laciniate fleshly aril — the mace. A) Q, R (B) P, R (C) P.S (D)Q, S

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(A) Compound starch grains (B) Cluster crystals of calcium oxalate (C) Lignified sclereids (D) Unlignified pericyclic fibres Q46. Chinese rhapontic rhubarb can be distinguished from Indian rhubarb by fluorescence developed in UV light which is: (A) Deep yellow (B) Deep violet (C) Green (D)Blue Q47. Citrus flavonoids are rich in A) Aesculetin (B) Fraxin (C) Hesperidin (D)Scopoletin

A) Atropic acid (B) Tropic acid (C) Pseudo cocaine (D)Tropinone Q50. A natural product derivative developed as an antimalarial is A) Artemether (B) Paludrine (C) Pyrimethamine (D) Haloffantrine Q51. Predict the product obtained by treating 6-chloro-3, 5-diamino pyrazin-2-methyl carboxylate with Guanidine A) Amiloride (B) Hydrochlorothiazide (C) Triamterene (D) Furosemide Q52. Glycyrrhizin, a sweet principle of liquorice is (A) K and Mg salts of glycyrrhizin ic acid (B) Na and Mg salts of glycyrrhetinic acid

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Q49. Eegonine, a hydrolytic product of cocaine on treatment with chromium trioxide gives a keto acid, which on thermal decarboxylation results in

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Q48. The alkaloid which inhibits the cholinesterase undergoes hydrolysis in solution to give methyl carbamic acid and eseroline is: A) Scopolamine (B) Pyridostigmine (C) Neostigmine (D) Physostigmine

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(C) K and Ca salts of glycyrrhizinic acid (D) Na and Ca salts of glycyrrhetinic acid Q53. Alloploids are polyploids derived from (A) a single parental species genome (B) more than one parental species genomes (C) a plant with haploid number of chromosomes (D) a plant with diploic number of chromosomes Q54. The colour and flavour of Saffron are due to -(P) Crocin (Q) Crocetin (R) Safranal (S) Crepenyic acid (A) R, S (B) P, R (C) Q, S (D)Q, P Q56. Group I Umbelliferous fruit Group II Diagnostic character (P) Fenel (1) Wavy scierenchyma (Q) Indian Dill (2) Bran ched and unbranched vittae (R) Coriander (3) Reticulaterly lignified parenchyma (S) Anise (4) Lateral ridges with vascular bundles

(A) P-1Q-4R-35-2 (B) P-2Q-3R-4S-1 (C) P-4Q-2R-1S-3 (D) P-3Q-2R-45-1

Q57. The quantitative values determined for the identification of leaf drugs remain constant throughout the age of the plant EXCEPT A) Stomatal number (B) Veinlet termination number (C) Veinislet number (D) Stomatal index

Q59. A transverse section of the root fo Glycyrrhiza glabra when treated with 80% sulphuric acid gave A) Deep yellow colour (B) No reaction, but only charring (C) Deep blue colour (D) Deep red colour Q60. Microscopy of the bulbs of Urginea Indica family Liliaceae shows (A) Prisms of calcium oxalate (B) Calcium carbonate and silica (C) Rosettes of calcium oxalate (D) Raphides of
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Q58. A sample of Cinnamomum zeylanicum purchased from the market was evaluated for its authenticity. It shows (A) presence of cork and cortex (B) absence of cork and cortex (C) absence of phloem fibres (D) presence of xylem parenchyma

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calcium oxalate Q61. The antihistamine with diphenyl methyl group is A) Methdilazine (B) Cyclizine hydrochloride (C) Pheniramine (D) Phenindamine Q62. Heterocyclic rings present in pilocarpine are (A) Imidazole and Quinoline (B) Imidazole and Thiazole (C) Quinoline and Phenanthrene (D) Imidazole and Dihydrofuran Q63. T he most important microbial virulence factor in the etiology of bacterial meningitis is A) Exotoxin (B) Components of the capsule (C) Coagulase (D) Hyaluronidase Q64. Commonly used tetanus vaccine is produced by (A) treatment of the causative organism with heat or UV light and finally obtaining the toxoid (B) sub-culuring the virus at pH 10.4 (C) artificially generating antibodies to viral glycoproteins (D) isolating the antigenicity genes from the causative organism Q65. (-) – Hyoscyamine is (A) 15-20 times more active as a mydriatic than (+)- hyoscyamine (B) Inactive as a mydriatic (C) 3-5 times less active as a mydriatic than (+)- hyoscyamine (D) 100 times more active as a mydriatic than (+)- hyoscyamine

Q67. Two tests for ephedrine are

Q68. Dried fruits of sweet fennel has two of the following properties (P) 80% of E-anethole, 10% of methyl chavicol and 5% (+) – fenchone as constitutents (Q) 65-75% (+)- Lin alool as a constitutent (R) The fruit is a diakene, almost cylindrical and surrounded by large stylopod (S) The fru it is elongated an d surrounded b y calyculus (A) P, R (B) Q, S (C) P, S (D) Q, R

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(P) A solution in dilute HCl, treated with copper sulphate and sodium hydroxide gives a violet colour (Q) An alcoholic solution gives a red colour with FeCl3 (R) On shaking with solvent ether, the organic layer shows purple while the aqueous layer becomes blue in colour (S) A solution of vanillin gives a violet-red colour (A) Q, S (B) P, S (C) P, R (D) Q, R

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Q66. Gram positive bacteria typically contain (A) cell walls that lack peptidoglycans (B) repeating un its of arabinogalactan and mycolates in their cell walls (C) Peptidoglycan containing muramic acid and D-amino acids in their cell walls (D) cell walls containing predominantly polysaccharides and glycoprotein

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Q69. Two of the following facts are associated with Ethylene oxide gas (P) It is non toxic and non inflammable and used for sterilization (Q) It is a colourless inflammable gas, toxic in nature and used for sterilization (R) It is diluted with CO2 (S) It cannot penetrate plastic and paper packaging (A) P, R (B) P, S (C) R, S (D) Q, R

Q71. Extracts of Chondrodendron tomentosum, family menispermaceae contains several alkaloids One of the important alkaloid is A) (-) Phyllandrene (B) (+) Holarrhenine (C) (+) Tubocurarine (D) (±) Colchicine Q72. This alkaloid has A) Bis benzyl tetrahydro isoquinoline ring (B) Quinoline ring (C) Phenanthrene ring (D) Pyrido pyrimidine ring Q73. Microscopic characters of ginger rhizome are (A) Spindle shaped lignified fibres and sclereids (B) Cluster crystals of calcium oxalate and sclereids (C) Non-lignified vessels and sac shaped starch grains (D) Non-lignified fibres and sclereids

Q74. Klunge’s test is for the identification of A) Barbaloin (B) Isobarbaloin (C) Aloinosides (D) Aloesin Q75. Group I Group II Glycoside Type P. Gentisin 1. Flavonol Q. Genistein 2. Flavone R. Apigenin 3. Xanthone S. Quercetin 4. Isoflavone (A) P-4,Q-3,R-1,S-2 (B) P-1,Q-2,R-4,S-3 (C) P-3,Q-4,R-2,S-1 (D) P-2,Q-1,R-3,S-4

Q76. Group I Group II Bark Diagnostic Microscopically Characters P. Kurch i 1. Heavily lignified phloem fibers with Y-shaped pits, secretory canals, micro crystals of calcium
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Q70. Match Group I and Group-II and identify the correct combinations Group-I Group-IIPlant Source (P) Thorn apple (1) Dried leaves and flowering tops of Hyoscyamus niger (Q) Henbane (2) Dried leaves and flowering tops of Datura Stramonium (R) Deadly nightshade (3) Leaves of Digitalis purpurea dried at a temperature below 60ºC (S) Foxglove leaves (4) Dried leaves and other aerialparts of Atropa acuminate (A) P - 2 Q - 1 R - 4 S - 3 (B) P - 1 Q - 2 R - 3 S – 4 (C) P - 3Q - 4 R - 2 S - 1 (D) P - 2 Q - 3 R - 4 S - 1

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oxalate Q. Cascara 2. Pericycle with stone cells having horse-shoe Shaped thickening, oil cells, minute needles ofcalcium oxalate R. Cinnamon 3. Alternating layers of stone cells and phloem, nonlignified pericyclic fibres, prismatic crystals of calcium oxalate S. Cinchona 4. Wavy medullary rays, groups of heavily lig nified sclereids, crystal sheath of calcium oxalate (A) P-2,Q-1,R-4,S-3 (B) P-4,Q-3,R-1,S-2 (C) P-3,Q-4,R-2,S-1 (D) P-1,Q-2,R-3,S-4

Q77. In Podophyllum toxin the lactone grp which is essential for the antimiotic activity must be a. b. c. d. Trans position Cis position E type Z type

Q78. Identify the True / False statement and fill in the blanks

1. Anthranol are more active than Anthraquinones 2. Anthranol gives strong florescence in alkali while Anthraquinones donot 3. GPP is formed from two units of IPP. 4. Starting material for Shikimic acid is PEP and Erythrose -4-P 5. Shikimic acid gives C C units 6. Naphthalene glycosides present in Senna are ……………………………. 7. Microscopic characteristics of Rhubarb is ………………………………. 8. ……………………… have haemotoxic and foaming properties. 9. …………………… is used as reference standard for bioassay of cardiac glycosides. 10. Microscopic characteristics of Quillaria bark is …………………………………….. 11. Wild chery bark have …………………………… type of glycosides 12. ………………….. is man like root 13. ………………… root have odour of methyl salicylate 14. ………………… is used in treatment of leucoderma 15. Khellin is smooth muscle relaxant is important constituent of ……………………. 16. ………………………… is pentacyclic Triterpenoids saponin 17. ……………………… bark is used as cardiotonic. 18. ……………………… bark is uterine tonic cause uterine contractions. 19. ………………………. Bark is used to treat dysentery 20. Tannin’s that donot give goldbeater’s skin test are called as ……………….. 21. …………………………. Anthelmintic for tapeworms. 22. …………………… alkaloidal drug on boiling with water produce acetophenone like smell. 23. …………………… benzaldehyde smell production on treatment with KMnO4. 24. …………………… Guggulosterone are used as an antihyperlipidamic

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