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Giulio Pergola

Giulio Pergola

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PENS WICN Summer School in Bangor, Wales, September 2008. GERMANY
PENS WICN Summer School in Bangor, Wales, September 2008. GERMANY

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Categories:Types, Research, Science
Published by: International Brain Research Organization on Jun 10, 2011
Copyright:Attribution Non-commercial


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Encoding and recall of picture associations activates multiple thalamo-cortical networks Giulio Pergola1,2, Alexander Ranft3, Irene

Daum1,2, Boris Suchan1,2
1Department 2International

of Neuropsychology, Faculty of Psychology, Ruhr-University Bochum, Germany Graduate School of Neuroscience, Ruhr-University Bochum, Germany 3Municipal Hospital Dortmund, Radiology Department, Dortmund, Germany

The present fMRI study tested the hypothesis that the mediodorsal nucleus of the thalamus (MD) processes recollective retrieval, while the anterior nuclei (AN) process encoding (Van der Werf et al., 2003). Subjects performed associative picture encoding followed by a recognition test during the scanning session (3T; TR: 2.3 s; TE: 35 ms; slice thickness: 3 mm, no gap). After scanning, subjects performed a cued partial and full recall test on the studied pictures. Trials were so classified: encoding followed by full (EF), partial (EP), and no recall (EN); retrieval followed by full (RF), partial (RP), and no recall (RN); correct rejections (CR); baseline task (odd/even numbers discrimination: BT). Individual condition/BT contrast images were compared at the group level with CR/BT contrast images by means of paired t-tests (whole brain FDR < .05). EF and EP activated bilateral clusters in the thalamus, mapping in the MD and intralaminar complex on the Talairach-Daemon atlas. RF and RP activated bilateral thalamic clusters mapping in the AN, MD, intralaminar and ventrolateral nuclei. A repeated measures ANOVA on the percent signal change within thalamic functionally defined ROIs mapping in the MD, with the factors INFORMATION (full, partial, null) and PHASE (encoding, retrieval) yielded main effects of INFORMATION (left: p < .001; right: p < .001) and PHASE (left: p = .014; right: p = .008; encoding > retrieval). Post-hoc comparisons revealed three significant differences within the INFORMATION factor (Full > Partial > Null, all p < .01). Consistent with Van der Werf et al. (2003), MD activation was critical for successful recall. However, MD activation was not limited to retrieval, but was found especially upon associative encoding. AN activation was only found at retrieval. This pattern of results accords with the existence of an MD-prefrontal cortical network subserving recall (Pergola et al., submitted).
G. Pergola, B. Suchan, O. Güntürkün, B. Koch, M. Schwarz, I. Daum. Effect of medial thalamic stroke on recognition memory and recall. Submitted. Van der Werf YD, Scheltens P, Lindeboom J, Witter MP, Uylings HB, Jolles J. Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesions. Neuropsychologia 2003; 41: 1330-1344.

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