Code No: 7A208/MT

BIOINFORMATICS (Biotechnology)

M.Tech. – II Semester Regular Examinations, September, 2008

Time: 3hours Answer any FIVE questions All questions carry equal marks --1.

Max. Marks:60

What are biological databases? Discuss the role of DBMS (Database Management System) in organisation, management and administration of databases. Explain the methods involved in sequencing and assembling a genome. Write short notes on: a) RNA secondary structure b) Si RNA design and development. What are scoring matrices? Explain the role of PAM and BLOSUM in multiple sequence alignment. Write short notes on a) Ramachandran plot and its significance in protein secondary structure analysis. b) Domains and Motifs. Discuss in detail the protein structure prediction by comparison: Homology - Based Modeling. What is computer – aided drug designing? Discuss the use of MOE in drug discovery. What is 2D-Gel electrophoresis? Explain the methodology and bioinformatics challenges in 2D-Gel Analysis. $$$

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