Proton pump inhibitor



Inhibits activity of acid (proton) pump and binds to hydrogenpotassium adenosine triphosphatase at secretory surface of gastric parietal cells to block formation of MECHANISM gastric acid. 40 mg IV OD







-short-term treatment for duodenal ulcer -treatment of heartburn or symptoms of GERD. INDICATIO




CNS: -Ampicillin esters, iron -Dosage adjustment may be necessary in dizziness, derivatives, asians and patient with hepatic headache ketoconazole: may impairment. GI: abdominal cause poor -Drugs increases its own biovailability pain, bioavailability of these with repeated doses. Drug is unstable in constipation, drugs because they gastric acid; less drug is lost to hydrolysis diarrhea, need a low gastric pH because drug inreases gastric pH. nausea, for optimal absorption. -Gastrin level rises in most patients vomiting Avoid using together. during the first 2 weeks of therapy. MUSCULOSKE -diazepam, phenytoin, -monitor drug levels. LETAL: back warfarin: may -tell patient to swallow tablets. pain decrease hepatic -caution patient to avoid hazardous RESP: cough, DRUG-DRUG, clearance, possibly activities ADVERSE NURSING if gets dizzy. upper leading to increased respiratory levels of drugs. tract infection Skin: rash

-reassess patient’s level of pain at least 30minutes after administration. -binds to receptors in the brain that are important for transmitting the sensation of pain from throughout the body. give drug before onset of intense pain. -monitor patients at risk for seizures. nausea. Reduce dosage. abdominal pain. -inhibit reuptake of norepinephrine and serotonin. headache. SSSRIs: may increase risk of serotonin syndrome.withdrawal symptoms may occur if drug is stopped abruptly. confusion. -monitor bowel and bladder function. centrally active analgesic Moderate to moderately severe pain. Carbamazipine: may increase tramadol metabolism. Drug may reduce seizure threshold. CV: vasodilation EENT: visual disturbances GI: constipation. REACTIONS/ SIDE EFFECTS CNS: dizziness. -monitor CV and respiratory status. -monitor patient for drug dependence. vomiting.IC NAME/ TRADE NAME TRAM ADOL ICATION NS OF ACTION FREQUENC Y/ DOSAGE 50mg IV every 8hrs IVTT. -do not stop the medication abruptly. diarrhea. anorexia FOOD-DRUG INTERACTION CONSIDERA-TION Synthetic . . -for better analgesic effect. Anticipate need for laxative.

diarrhea.: apnea. Begin therapy awaiting test results. -monitor patient’s fluid balance and weigh carefully. . methicilli nsusceptibl e isolates only) Adrenergic drugs.GENERIC NAME/ TRADE NAME MEROPENE M CLASSIFIC A-TION INDICATI ONS MECHA NISM OF ACTION Inhibits cell-wall synthesis in bacteria. bacterial meningitis. dyspnea DRUG-DRUG. Readily penetrat es cell wall of most grampositive and negative bacteria to reach penicillin -binding protein targets. Serotoninergic drugs: may cause serotonin syndrome Food and beverages high in tyramine: may increase BP -obtain specimen for culture and sensitivity tests before giving. stop infusion and notify prescriber. . Dosage adjustment may be needed. glossitis. -monitor patient’s fluid balance and weight carefully. dopamine. -periodic assessment of organ system functions is recommended during prolonged therapy. pain. epinephrine: may cause hypertension. and compromised renal function. ROUTE/ FREQU ENCY/ DOSAG E 500 mg IV q 12 hrs ANST (-). thromboph lebitis GU: RBC’s in urine SKIN: pruritus GI: constipatio n. drug may cause seizures and other CNS adverse reactions. -in patient with CNS disorders. nausea Resp. ADVERSE REACTIO NS/ SIDE EFFECTS CNS: headache.if seizure occur during therapy. FOOD-DRUG INTERACTION NURSING CONSIDERATION Antibiotic Complicat ed skin and skin structure infections from staphyloc occus aureus(be talactamas e or nonbetalactamas e producing . seizures CV: phlebitis. -monitor patient for signs and symptoms of super infection.

Monitor pt. agitation. Antihypertensi ve: may enhance hypotensive effects.GENERIC NAME/ TRADE NAME RISPERID ONE CLASSIFIC A-TION INDICATIO NS MECHA NISM OF ACTION ROUTE/ FREQUEN CY/ DOSAGE ADVERSE REACTIO NS/ SIDE EFFECTS CNS: akathisia. heahache. For wight gain -periodically reevaluate drug’s risk and benefits. especially during prolonged use. despite stopping drugs. orthostatic hypotensio n. Blocks 2mg ¼ tab dopamin e and 5Ht2 receptor s in the brain. anxiety. -monitor patient for tardive dyskinesia. fatigue CV: tachycardi a. -life-threatening hyperglycemia may occur in patients taking atypical antipsychotic. dizziness. -monitor pt. chest pain. pain. Alcohol use: may cause additive CNS depression. For tardive dyskinesia. With diabetes regularly. FOOD-DRUG INTERACTION NURSING CONSIDERA-TION Benzisoxaz ole derivative -short-term treatment of schizophre nia and acute manic or mixed episodes from bipolar 1 disorder. CNS depressants: may cause addtive -obtain baseline BP before the therapy. fever. peripheral edema EENT: DRUG-DRUG. -life-threatening hyperglycemia may occur in pts taking atypical antipsychotics. -monitor pt. impaired concentrat ion. which may occur after prolonged use. . It may not apper until months or year later and may disappear spontaneously or persist for life. and decrease effectiveness. Carbamazepin e: may increase risperidone clearance.

vomiting. leg pain Skin: rash. abnormal vision GI: constipatio n. pharyngiti s. nausea. sinusitis. dyspepsia. dry skin . increase urination Musculosk eletal: back pain.rhinitis. abdominal pain GU: urinary incontinen ce.

cholestyra mine. . weight control and exercise. -drug may be given as a single dose at any time of day. FOOD: Grapefruit NURSING CONSIDERA-TION ATORVAS TATIN (LIPITOR) Antilipemi cs Increased LDL. ½ CNS: headache. -can be taken with or without meal.use only after diet and other nondrug therapies prove ineffective. insomnia CV: peripheral edema EENT: rhinitis. colestipol: may decrease atorvastati n level. sinusitis GI: abdominal pain. Should follow a standard low-cholesterol diet before and during therapy. assess pt. -warn patient to avoid alcohol. FOODDRUG INTERACTI ON Antacids. -obtain baseline lipid profile. with or without food. -before treatment. For underlying causes for . diarrhea. -teach patient about proper diet management.GENERIC NAME/ TRADE NAME CLASSIFI CA-TION INDICATI ONS MECHANIS M OF ACTION ROUTE/ FREQUEN CY/ DOSAGE ADVERSE REACTIO NS/ SIDE EFFECTS DRUGDRUG. constipatio n. Digoxin: may increase digoxin level. Pt. -Wacth for signs of myositis. triglycerid es -Lowers the 80mg level of tab OD blood cholesterol -prevent production of cholesterol in the liver by blocking HMG-CoA reductase.

flatulence Metabolic: DRUGDRUG. flecainide. obtain blood pH.flatulence GU: UTI Skin: rash juice: may increase drug levels. abnormally high alkalinity in tissues and fluids or kidney stones. Obtain periodic liver function test results and lipid levels before starting treatment and at 6-12 weeks after initiation. partail pressure of arterial .to avoid risk of alkalosis. -tell patient not to take drug with milk because doing so may cause high levels of calcium in the blood. -obtain ABG. hypercholesterolemia an obtain a baseline lipid profile. or after an increase in dosage and periodically thereafter. GENERIC NAME/ TRADE NAME CLASSI FICATION INDICATIO NS MECHANIS M OF ACTION ROUTE/ FREQUE NCY/ DOSAGE ADVERSE REACTIO NS/ SIDE EFFECTS CNS: tetany CV: edema GI: gastric distention. belching. mecamyla mine: may decrease renal clearance NURSING CONSIDERA-TION SODIUM BICARBONA TE Alkaliniz er -metabolic acidosis -systemic or urinary alkalinizatio n -antacid Restores 10cc/hr buffering IV capacity of the body and neutralizes excess acid. FOODDRUG INTERACTI ON Anorexiant s. increasing risk of adverse reactions. .

K / Fat Prevention Cofactor for IVTT 1 GI: gastric -monitor for frank and occult . hypernatre mia Skin: pain and irritation at injection site of these drugs and increase risk of toxicity.hypokalem ia. metabolic alkalosis. increase renal clearance of these drugs and decrease their effect. FOODDRUG INTERACTI ON NURSING CONSIDERA-TION Vit. Tell prescriber laboratory results. Lithium. and electrolyte levels. tetracyclin e: may increase urine alkalinizatio n. -oral products may contain 27% sodium GENERIC NAME/ TRADE NAME CLASSIF ICATION INDICATIO NS MECHANIS M OF ACTION ROUTE/ FREQUEN CY/ DOSAGE ADVERSE REACTIO NS/ SIDE EFFECTS DRUGDRUG. oxygen. partial pressure of arterial carbon dioxide.

-monitor pulse & BP frequently. -caution pt. -don’t use if the solution is cloudy or if with container is damaged. rash. FOODDRUG INTERACTI ON NURSING CONSIDERA-TION NEPHROST ERIL Parente ral nutritio nal product s Supply of protein elements in acute and chronic renal failure. GENERIC NAME/ TRADE NAME CLASS IFICATION INDICATIO NS MECHANIS M OF ACTION ROUTE/ FREQUEN CY/ DOSAGE ADVERSE REACTIO NS/ SIDE EFFECTS NONE DRUGDRUG. do not floss and shave w/ an electric razor until coagulation defect is corrected. to avoid IM injections and activities leading to injuries.Phytome nadione soluble vitamins & treatment of hypoprothr ombinemia which may be associated with excessive doses of oral anticoagula nts. -use a soft toothbrush. glutamic acid. unusual taste Derm: flushing.5g amino acids/kg body wt/day -monitor serum electrolytes. that (1mg) catalyzes the carboxylati on of the amino acid. urticaria Hema: hemolytic anemia bleeding. upset. . salicytates an enzyme amp. serum urea. resulting in its conversion to gammacarboxyglut amic acid. peritoneal & hemodialys is 0. fluid and acid-base balance.

GENERIC NAME/ TRADE NAME CLASSIF ICATION INDICATIO NS MECHANIS M OF ACTION ROUTE/ FREQUEN CY/ DOSAGE ADVERSE REACTIO NS/ SIDE EFFECTS CNS: dizziness. FOODDRUG INTERACTI ON Antacids: may cause gastric irritation of dyspepsia from premature dissolution of enteric coating. Musculosk DRUGDRUG. by irritating the muscle or stimulating the colonic intramural plexus. Suppositor y 10mg. -teach patient about the dietary sources of bulk. hypokalem ia. fluid and electrolyte s imbalance s. muscle weakness GI: abdominal cramps. nausea and vomiting Metabolic: alkalosis. -insert suppository as high as possible into the rectum and try to position suppository against the rectal wall. . Milk: may cause gastric irritation of dyspepsia from premature dissolution of enteric coating. Separate doses by at least 1 or 2hrs. Don’t use NURSING CONSIDERA-TION BISACOD YL(dulcol ax) Diphenyl methane derivativ e Chronic constipatio n Stimulate laxative that increases peristalsis.treatment. including bran and other cereals. Fresh fruits and vegetables. -give drugs at times that don’t interfere with scheduled activities or sleep. burning sensation in rectum with suppositori es. Soft. probably by direct effect on smooth muscle of the intestine. formed stools are usually form 15-60 minutes after rectal use.

eletal: tetany within 1 or 2 hrs of drinking milk. .

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