Predisposing Factors:  Age  Gender  Race  Lifestyle  Early Menarche a. Nulliparity b. Use of oral contraceptives Estrogen Dominance h.

High-fat Diet i. Obesity j. Family history k. Anxiety ETIOLOGY: Unknown

Precipitating Factors: a. Hormone Replacement

Therapy (Premarin)  b. Anovulation Luteal Insuffiency

S/Sx: -swelling of breasts

Treatment: -GnRH agonist -Tamoxifen -SERM

If not treated Proliferation of cells in the uterus Overgrowth of the endometrial lining Diagnostic Tests: -Pelvic examination -Ultrasonography Interference in the vascular supply

-depression -loss of sexual drive -dysmenorrhea

Development of uterine fibroid

Degeneration in the interior part of the fibroid

Sx: Hypermenorrhea

If treated with radiation

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