List of Major Endocrine Disorders

LIST OF ENDOCRINE DISORDERS: Disorder

:
1) Pituitary Dwarfism:

Hormone defect:
Growth hormone deficiency, Decreased GH, Decreased IGF (SM)

2) Laron Dwarfism:

Growth hormone elevated , GH Receptors defective, decreased IGF (SM)

3) Gigantism/ Giantism: 4) Acromegaly: 5) Sheehan’s Syndrome:

Growth hormone excess before puberty Growth hormone excess after puberty Postpartum anterior pituitary necrosis, decreased anterior pituitary hormones, normal ADH & Oxytocin levels

6) Diabetes Insipidus:

Deficiency of Antidiuretic hormone (ADH) Neurogenic- Decreased ADH levels due to Hypothalamic/ Posterior pituitary lesions Nephrogenic - ADH levels elevated, ADH receptors / Aquaporins are defective Seen in patient’s on Lithium Carbonate

7) Myxedema: 8) Cretinism: 9) Grave’s Disease: 10) Hashimoto’s Thyroiditis: 11) Primary Hyperparathyroidism (Parathyroid tumor):

Hypothyroidism in adults Hypothyroidism in children Autoimmune Hyperthyroidism Autoimmune Hypothyroidism Increased Parathyroid hormone (PTH) Increased PTH

12) Secondary hyperparathyroidism: (Cancers of lung & breast, in Chronic renal failure):

13) Hypoparathyroidism - TETANY (Accidental removal of parathyroid gland during Thyroid surgery): Decreased PTH- decreased serum calcium • Pseudohypoparathyroidism – Albright’s Heriditary Osteodystrophy – Elevated PTH, defective Gs Proteins destroy PTH receptors Vitamin D deficiency in children Vitamin D deficiency in adults

14) Rickets: 15) Osteomalacia:

16) Congenital virilizing Adrenal hyperplasia (Adrenogenital Syndrome): 21 & 11β- Hydroxylase deficiency- Excess Androgens 17) Deficiency of 17α- Hydroxylase: Decreased Androgens & Glucocorticoids, Increased Mineralocorticoids

18) Addison’s Disease:

Primary Adrenocortical insufficiency Adrenocortical excess Hyperaldosteronism (Aldosterone excess) Adrenal Medullary tumor Insulin deficiency Insulin levels high. Downregulation of Insulin Receptors

19) Cushing’s Syndrome (CUSHION=fat): 20) Conn’s Syndrome: 21) Phaeochromocytoma: 22) Diabetes Mellitus Type I: Diabetes Mellitus Type II:

WISH YOU ALL THE BEST IN THE FORTHCOMING EXAMS!!!!!

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