DRUG STUDY Name of Patient Diagnosis Doctor Mechanism of Action Pharmacokinetics: Onset, Duration: unknown Peak: Immediate Absorption:

Absorbed from the GI tract with peak plasma concentrations after 2-3 hr (oral); may be enhanced by the presence of food. Distribution: Pleural and synovial fluid, sputum, bone and aqueous fluids; CSF (therapeutic concentrations). Crosses the placenta and enters breast milk. Protein-binding: Up to 50%. Metabolism: Rapidly hydrolysed (intestinal mucosa and blood). Excretion: Via the urine by glomerular filtration and renal tubular secretion (as unchanged); via bile Age Sex Date of Admission Height Weight Body Build Nursing Responsibilities Before: 1. Consider 10 rights of drug administration. 2. Assess for hypersensitivity. 3. sensitivity tests 4. Obtain hepatic and renal impairment, 5. Consider dugs interaction. 6. For each 750mg vial of Zinacef, reconstitute with 8ml sterile water During: 1. Inject into tubing of free-flowing I.V. solution over 3-5 mins 2. `For intermittent infusion, add reconstituted drug to 100 ml D5W, normal saline solution for injection. Infuse over 15-60 mins. 3. Incompatible with aminoglycosides, ciprofloxacin, clarithromycin, filgrastim, fluconazole, midazolam 4. Discontinue if

Drug Data Generic Name: cefuroxime Trade name: Aeruginox, Altacef, Ambixime, Bactipoz, Cefogen,Ceftin, Cefucil, Cefuzime, Zefur, Zinacef, Zinnat Patients Dosage:

Classification Pharmacologic: secondgeneration cephalosporin Therapeutic: Antibiotic Category: B

Indication General: - Lower respiratory infections - Dermatologic infections - UTIs - Uncomplicated and disseminated gonorrhea - Septicemia - Meningitis - Bone and joint infections - Perioperative prophylaxis - Treatment of acute bacterial maxillary sinusitis in patients 3 mo12 yr Patients Indication:

Contraindications Contraindications: -hypersensitivity to drugs and its components Precautions: - renal impairment -children less than 2 years of age Drug Interactions: Diuretics: Increase risk of adverse renal reactions Probenecid: Inhibit excretion and increase level of cefuroxime

Adverse Reaction GI: abdominal cramps, anal pruritus, anorexia, diarrhea, dyspepsia, glossitis, nausea GU: genital pruritus, and candidiasis Skin: maculopapular and erythematous rashes, urticaria Hema: eosinophilia, hemolytic anemia Respiratory: dyspnea CNS: dizziness, headache, malaise, paresthesia

Availability: Infusion: 750mg, 1.fg premixed, frozen solution Injection: 750 mg, 1.5g Minimum Dosage: 75-100 mg/kg/day Maximum Dosage: 8 g/day Route of administration: IVTT

(small amounts); 70 min (elimination halflife); prolonged in neonates and renal impairment. Pharmacodynamics: binds to one or more of the penicillinbinding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Source: http://RNpedia.com- Nursing Notes and Community

hypersensitivity reaction occurs. 5. Monitor clients clinical response. After: 1. Teach patient about drugs side effect. 2. Encourage patient Comply religiously the full course of therapy. 3. Report severe diarrhea, difficulty breathing, unusual tiredness or fatigue, pain at injection site. 4. Promote comfort measures. 5. Assess patient's condition thereafter the therapy.