Professional Documents
Culture Documents
CONTENTS
ADVANCES IN
SOLID DOSAGE FORMS 2. SEMISOLID DOSAGE FORMS 3. GRANULATION TECHNIQUES 4. COATING TECHNOLOGIES 5. ORAL DRUG DELIVERY 6. CR TECHNOLOGIES
1.
MUPS
MUPS EX: Beloc ZOK , Antra MUPS and Prevacid SoluTabTM, Nexium, Acimax, Losac.
Foam drug delivery Rectal ointments Creams a) containing microspheres b) containing lipid nano particles c) Lamellar faced creams Delivery of monoclonal antibodies , vitamins, epidermal growth factors is under research.
INT.J. PHARMTECH RES.2011,3(1)
GELS
CR gels Hydrophilic gels Amphiphilic gels Organo gels Non aqueous gels Bioadhesive gels Thermosensitive gels Complexation gels
ORGANO GELS
GRANULATION TECHNIQUES
PNEUMATIC DRY GRANULATION (PDG)
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES REVIEW AND RESEARCH, VOLUME 5, ISSUE 3, NOVEMBER DECEMBER 2010.
The use of a low compaction force produces soft and porous granules that can be fractionated with the above fractionating device. Low compaction force is advantageous because it preserves the maximum amount of binding capacity for the tabletting phase and it alters minimally the chemical or physical properties of the API as opposed to conventional methods.
The fractionating device selects particles according to their flowability and they adhere in the process by electrostatic means rather than using chemical bindings (water).
Foam granulation takes advantage of the tremendous increase in the liquid surface area and volume of polymeric binder foams to improve the distribution of the water/binder system throughout the powder bed of a solid dose pharmaceutical formulation. A simple foam generation apparatus is used to incorporate air into a conventional water-soluble polymeric excipients binder such as METHOCEL hypromellose (hydroxypropyl methylcellulose). The resulting foam has a consistency like shaving cream. Hypromellose polymers are ideal candidates for this technology because they are excellent film formers and create exceptionally stable foams. In a small-scale laboratory setting or in a full-scale production setting, the foam generator can be connected directly to high-shear, low-shear, or fluid bed granulation equipment.
Melt granulation is processes by which granules are obtained through the addition of either a molten binder or a solid binder which melts during the process. This process is also called melt agglomeration and thermoplastic granulation.
STEAM GRANULATION
This steam injection method, which employs steam at a temperature of about 150 C., tends to produce local overheating and excessive wetting of the particles in the vicinity of the steam nozzles, thereby causing the formation of lumps in the granulated product.
In this method moisture is used to activate the granules formation but the granules drying step is not necessary due to moisture absorbing material such as MCC.
Photocurable coating, Magnetically assisted impaction coating, Compression coating, Gelatin coating, Hot melt coating, Powder coating, Electrostatic dry coating, Supercritical fluid coating.
COMPRESSION COATING
Used in the recent years for creating modified-released products. It involves the compaction of granular materials around a preformed tablet core using speciallydesigned tableting equipment. Compression coating is a dry process
http://www.pua.edu
GELATIN-COATED TABLETS
This allows the coated product to be about onethird smaller than a capsule filled with an equivalent amount of powder. The gelatin coating facilitates swallowing. Gelatin coated tablets are more tamper evident than unsealed capsule.
HOTMELT COATING
Hot melt coating utilizes a solvent-free fluidized bed technology to deposit a lipid film coating onto the surface of drug particles.
http://www.gate2tech.com/article.php3?id_article=6
POWDER COATING
http://www.patheon.com/Portals/0/Scientific%20Papers/Published%20 Articles/tc_20100401_0018.pdf
The basic principle of electrostatic spraying concerns propulsion of the dry powder by compressed air through a spray gun, by which it becomes electrically charged and then moves and adheres to the earthed substrate surface.
EX: Chronocort
EXAMPLES
TECHNOLOGY SODAS IPDAS CODAS GEOCLOCK GEOMATRIX MARKETED PRODUCTS AVINZA, RITALIN LA AND FOCALIN XR. NAPRELAN VERELAN LODOTRA SULAR, ZYFLO CR, CORUNO, RATIOPHARM UNO AND MADOPAR DR. INNOPRAN XL SLOFEDIPINE XL (NIFEDIPINE) AND CYSTRIN CR (OXYBUTYNIN). ZOLADEX, DUROS. LUPRON, PROFACT
DIFFUCAPS TIMERX
IMPLANTS PROLEASE
REFERENCES.
A FLEXIBLE TECHNOLOGY FOR MODIFIED-RELEASE DRUGS: MULTIPLE-UNIT PELLET SYSTEM (MUPS), JOURNAL OF CONTROLLED RELEASE 147 (2010) 216. DEVELOPMENT OF SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEMS: PREPARATION TECHNIQUES AND DOSAGE FORMS, DRUG DISCOVERY TODAY VOLUME 13, NUMBERS 13/14 JULY 2008. A REVIEW ON ORAL MUCOSAL DRUG DELIVERY SYSTEM, IJPSR (2010), VOL. 1, ISSUE 5. RECENT ADVANCES IN GRANULATION TECHNOLOGY, IJPSR, VOLUME 5, ISSUE 3, NOVEMBER DECEMBER 2010
CHALLENGES AND STRATEGIES IN NOVEL DRUG DELIVERY TECHNOLOGIES, PHARMA TIMES - VOL 38 - NO. 4 - APRIL 2006. CONTROLLED-RELEASE OF ORAL FORMULATION, FILL & FINISH 2003. DOSAGE FORMS,
SOLVENTLESS COATING TECHNOLOGY FOR SOLID PHARMACEUTICAL DOSAGE FORMS , INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH 2009; 1(2): 55-61 55 . PHARMACEUTICAL CO-CRYSTALS: A REVIEW, INDIAN PHARM SCI. 2009 JULAUG; 71(4): 359370 J
A REVIEW : NOVEL ADVANCES IN SEMISOLID DOSAGE FORMS & PATENTED TECHNOLOGY IN SEMISOLID DOSAGE FORMS, INT.J. PHARMTECH RES.2011,3(1). ADVANCES IN PHARMACEUTICAL COATINGS, INT.J. CHEMTECH RES.2010,2(1) APPLICATION OF HOT-MELT COATING PROCESS FOR DESIGNING A LIPID BASED CONTROLLED RELEASE DRUG DELIVERY SYSTEM FOR HIGHLY AQUEOUS SOLUBLE DRUGS, CHEM. PHARM. BULL. 57(5) 464471 (2009) http://www.pua.edu http://www.gate2tech.com/article.php3?id_article=6
MOUTH DISSOLVING TABLETS I: AN OVERVIEW OF FORMULATION TECHNOLOGY, SCI PHARM. 2009; 76; 309326.
ACKNOWLEDGEMENTS
SPECIAL THANKS TO MY FRNDS NIKHIL, SHANTHA KUMAR AND SHARAD JAIN WHO HELPED ME IN LITERATURE SREACH.
THANK YOU