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Biochemistry II

Biochemistry II

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Published by Shubhamoy Ghosh

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Published by: Shubhamoy Ghosh on Sep 24, 2011
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10/09/2013

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What is the totalenergy yield (number of ATPs) from oxidizing one
molecule of palmitic acid to CO2? Palmitic acid has 16 carbons, so
you can break it down into eight acetyl-CoAmolecules, with the for-
mation of one FADH2and one NADH at each of the seven β-oxida-
tion steps. Electron transport starting with FADH2yields two ATPs
and with NADH yields three ATPs. Therefore, β-oxidation yields the
equivalent of 35 ATPs per molecule of palmitic acid. Each acetyl-
CoAgoes into the TCAcycle, where its metabolism yields three
NADHs, one FAD, and one GTPdirectly, for a total of 12 ATPs. Thus,
the ATPs produced are:

7 ×5 + 8 ×12 = 35 + 96 = 131

Two ATPequivalents were used to activate the fatty acid, lead-
ing to a total energy yield of 129 ATPs, over three times the amount
of energy obtained from metabolizing a single molecule of glucose.

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