Professional Documents
Culture Documents
Synthesis of
Vitamin D
Vitamin D
• Vitamin D is a lipid soluble hormone that binds to
a typical nuclear receptor, analogous to steroid
hormones.
• Because it is lipid soluble, it travels in the blood
bound to hydroxylated α-globulin.
• There are many target genes for Vitamin D.
Vitamin D action
• The main action of 1,25-(OH)2-D is to stimulate
absorption of Ca2+ from the intestine.
• 1,25-(OH)2-D induces the production of calcium
binding proteins which sequester Ca2+, buffer
high Ca2+ concentrations that arise during initial
absorption.
Clinical correlate
• Vitamin D-dependent rickets type II
• Mutation in 1,25-(OH)2-D receptor
• Disorder characterized by impaired
intestinal calcium absorption
Vitamin D and Bones
• Proper bone formation is stimulated by
1,25-(OH)2-D (the active hormone)
• In its absence, excess osteoid
accumulates from lack of 1,25-(OH)2-D
repression of osteoblastic collagen
synthesis
• Inadequate supply of vitamin D results in
rickets, a disease of bone deformation
Parathyroid Hormone (PTH)
• PTH is synthesized and secreted by the
parathyroid gland which lie posterior to the
thyroid glands
• The blood supply to the parathyroid glands
is from the thyroid arteries
• The Chief Cells in the parathyroid gland
are the principal site of PTH synthesis
Synthesis of PTH
• PTH is translated as a pre-prohormone
• Cleavage of leader and pro-sequences
yield a biologically active peptide of 84 aa
• Cleavage of C-terminal end yields a
biologically inactive peptide (this doesn’t
matter)
Regulation of PTH
• The dominant regulator of PTH is plasma
Ca2+