CLASSIFICATION OF ENZYMES CLASS 1

OXIDOREDUCTASES
CLASS 1 : OXIDOREDUCTASES
These enzymes catalyze oxidation-reduction reactions .

Subclasses of the Oxidoreductases
Oxidases – transfer two electrons from the donor to oxygen, resulting usually in hydrogen peroxide formation. Cytochrome Oxidase – produces H2O rather than H2O2. Oxygenases –catalyze the incorporation of oxygen into a substrate.

Catechol oxygenase –catalyze the dioxygenase reaction; steroid hydroxylase illustrates a monooxygenase reaction. Peroxidases –utilize H2O2 rather than oxygen as the oxidant. Catalase –is unique in that H2O2 serves as both donor and acceptor. It function in the cell to detoxify H2O2.

CLASS 2

TRANSFERASES

Class 2: Transferases
These enzymes transfer functional groups between donors and acceptors. Aminotransferases(transaminases) –transfer an amino group from amino acid to an alpha-keto acid receptor,resulting in the formation of the new amino acid and a new keto acid.

Class 3
HYDROLASES
Class 3: Hydrolases
This group of enzymes can be considered as a special class of the transferases in which the donor group is transferred to water. The generalize reaction involves the hydrolytic cleavage of C-O, C-N, O-P, and C-S bonds. Peptidases –a special class of hydrolases that are proteolytic enzymes

CLASS 4
LYASES
Class 4: Lyases
Lyases add or remove the elements of water, ammonia, or carbon dioxide. Decarboxylases –remove the element of CO2 from alpha or betaketo acids or amino acids. Dehydratases –remove H2O in a dehydration reaction.

CLASS 5 ISOMERASES
Class5: Isomerases

This very heterogeneous group of enzymes catalyze isomerizations of several types.this include cis-trans and aldose–ketose interconversions. Epimerases or racemases- isomerases that catalyze inversion at asymmetric carbon atoms. Mutase –involved intermolecular transfer of a group such as phosphoryl

Examples
rotamase protein disulfide isomerase (PDI) epimerase racemase

CLASS 6 LIGASES
Class 6: Ligases
This enzymes are involved in synthetic reactions where two molecules are joined at the expense of a “ high-energy phosphate bond” of ATP. Synthetase –reserved for this particular group of enzymes.

Examples
Peptide Synthase Aminoacyl-tRNA Synthetase DNA Ligase RNA Ligase

To be continued….
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