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Published by Errol B. Tiozon

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Published by: Errol B. Tiozon on Oct 03, 2011
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11/10/2013

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Pathophysiology Non-Modifiable Factors Age Gender Familial Tendencies Modifiable factors Smoking Lack of exercise Diet high

in Cholesterol Stress Hypertension Elevated Serum Cholesterol Alcohol

Insulin Resistance Increase in beta cell secretion Dec. Glucose Uptake Intracellular Hypoglycemia Extracellular hyperglycemia Inc. Lipolysis Inc. Glucose production

Hyperglycemia Hypercoagulability

Glucogenesis and Gluconeogenesis Breakdown of fats High level of ketones Diabetic Ketoacidosis

Blood glucose> renal threshold Non-specific injury to arterial wall Glycosuria Desquamation of endothelial lining

Osmotic diuresis Polyuria, Polydipia Polyphagia

Inc. permeability or adhesion of molecules LDL and platelets assimilate in the area

Oxidized LDL attracts monocytes and macrophages to the site Plaques begins to form from cells w/c imbibed into the endothelium Lipids are engulfed by the foam cells and smooth muscle cells develops Disruption of plaque leads to continuous aggregation of platelets Thrombus formation Rapid increase in size of the thrombus in coronary artery Dec. blood supply in the myocardium

Dec. myocardial oxygen supply

Myocardial Ischemia

Crackles) . in pumping action as a compensatory mech. RBC Stimulation of RAS Na and water Retention Deterioration of heart’s ability to pump Vasoconstriction Moderate left ventricular failure LV is unable to fully eject the returning blood to the systemic circulation Blood returns to the pulmonary circulation Pulmonary congestion (Dyspnea. GFR Inc. Myocardial contractility Dec. dizziness Activation of baroreceptors in the LV. Dec. perfusion of organs of the body Activation of the SNS Dec. WBC Conduction System Disorder Pyrogens will stimulate the release of prostaglandin Dec. carotid sinus Dec. aortic arch. cough. Creatinine Dec. Cardiac Output Inadequate cerebral Perfusion Dec. Urea Inc.Anaerobic metabolism Myocardial cell necrosis More lactic acid production Chest pain Acidosis Inflammatory response Release of endogenous pyrogens Inc. systemic circulation Prostaglandin will set the hypothalamic thermostat to high Fever Loss of consciousness Fatigue. Renal perfusion Inc.

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