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IRON COPPER Iodine Fluoride

Properties Well conserved; 90% recycled 75 % thyroid gland


25% lactating
mammary gland
3-5 g; 100 – 150 g 20-30 g 2.5 mg
30 % TOTAL IRON BINDING
CAPACITY
Absorption 1. HEME iron  porphyrin complex 1. assoc. w/ METALLOTHIONEIN
2. NON-HEME  Fe2+
(by gastric juice)
Transport 1. Mucosal Tf + Apf = FERRITIN 1. bounded to ALBUMIN
(intes’l lumen to mucosal cells)
2. Serum Tf – carries Fe3+ (mucosal
cells to tissues)
Storage 1. FERRITIN – readily mobilized 1. bound to CERULOPLASMIN
2. HEMOSIDERIN – not mobilized  BRAIN, HEART, LIVER and
 LIVER, BM, SPLEEN and MXs Kidneys
Excretion 1. Bleeding 1. Bile
2. Feces, sweat
3. Exfoliation
Function 1. O2 transport – Hb and Mb 1. Coenzyme 1. integral part of TH 1. resistance to dental caries
2. Oxidative Prod. of ATP via a. cyt c oxidase 2. FLUORAPATITE
REDOX (Fe2+  Fe3+) – b. SOD – replaced OH group in Ca2+ P04-
cytochromes c. tyrosinase salts
3. P450 system – H20 insol.  sol. d. lysyl oxidase - less absorbed < hydroxyapatite
4. Immune system 2. O2 of Fe2+ before transport
a. neutrophils, WBC 3. Collagen Cross-linking
b. Tf and Lacto Tf 4. mito ENERGY production
5. Cognitive Performance 5. ANTI-OXIDANT
6. synth. of Melanin and Catecholamine