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Scientific Brochure

Science for healthy skin.

Table of contents

Preface by Dr. Heinz Maurer Preface of the Scientific Advisory Board The acid mantle of the skin
The pH value of the skin is slightly acidic The acid mantle stabilizes the ecological balance of the skins micro-flora The proliferation and differentiation of the skin cells is pH-dependent The acid mantle stabilizes the barrier structures of the Stratum corneum lipids The acid mantle supports the synthesis of barrier forming lipids within the Stratum corneum

4 5 6 7 8 9 10 11 12 13-14 15 16-18 18-19 20-23 24-25 26-27 28-32 33-35 36 37-39 40-41 42-43 44-45 46-47

The influence of skin care on the acid mantle


Washing with soap impairs the acid mantle Even pH neutral skin cleansing influences the skin surface pH Influence of the pH value of cleansing preparations on the skins micro-flora Influence of the pH value on the dehydration of the skin Influence of the application of skin care products on the pH value of the skin

sebamed soap-free skin cleansers sebamed Feminine Intimate Wash sebamed protective care products sebamed hair care system sebamed Deodorants Baby sebamed Clear Face sebamed sun care sebamed Anti-Dry sebamed Anti-Ageing sebamed F+S Fine+Sensitive sebamed Visio Literature

Preface by Dr. Heinz Maurer


Skin care is a basic human need: it starts with cleanliness. Besides its hygienic function, cleanliness also has an integrative social role in modern society. Therefore it has become a seemingly self-evident necessity in everyday life. However, this fact also creates considerable dermatological problems for a large group of people. My primary motivation for the development of sebamed was my experience in the Dermatological Department of the University of Bonn in the 1950ies. At this time a soap prohibition existed for patients with skin diseases. This hardly tolerable stress drove my search for a solution. The first successes with soap-free tensidic products encouraged me to carry on with the development of a preparation for the cleansing of problem skin.
photographed by J.H. Darchinger

Preface of the Scientific Advisory Board


In 2006, the average per capita spending on skin care in Western Europe (EC-countries, Switzerland and Norway) was 147 Euro, amounting to a total 4.2 Billion Euro spend on cosmetic products in Western Europe. This fact alone indicates the significance of skin care in modern society. Reflecting on this statistical data and the fact that skin care can have positive, as well as, negative effects on the skin, research activities, especially in the fields of Dermatology, Chemistry, and Pharmacy are necessary to elucidate the interactions between the organ skin, the environment, and skin care products; and to contribute to optimizing the efficacy and safety of skin care products. The value and rewards of such efforts are demonstrated by the essential benefits, that have been achieved for such population groups as the 20%, who suffer from a genetic disposition to dry skin, which is further provoked by the daily cleansing with soaps or syndets and deteriorated by this irritation of the skin; or the 80% of adolescents with predominantly moderate forms of acne. The deterioration of the latter skin condition caused by the regular use of soap, can be avoided by using an acidic syndet. In skin diseases, adequate skin care can provide substantial support of the therapy and healing process. Its not insignificant to mention the role that skin care plays, in contributing to the maintenance of the skin's health, and in the prevention of skin damage and diseases. Medicinal skin care requires intensive efforts in dermatological research . Dermatological research has made significant advances in recent years. This incremental increase in the understanding of the physiology and pathology of the skin has lead to establishing fundamental requirements for medicinal skin care and the development of objective methods to evaluate the efficacy and safety of products. State-of-the-art dermatological research calls for a scientific benefit-risk-analysis similar to that for drugs. This brochure documents the medical/scientific evaluation of the in-use benefit- risk analysis of sebamed products, which has played a prominent role from the very beginning. The presented studies also demonstrate the progress, which has been achieved in the evolution of the methods utilized for product testing and evaluation in the course of the last decades. Since 1992, the Scientific Advisory Board of Sebapharma has provided Sebapharma with its vital connection to the scientific community devoted to dermopharmaceutical research. The establishment of this interdisciplinary co-operation has proven to be of special value, which is expressed in the research results presented on the following pages.

The result was the market introduction of sebamed Cleansing Bar forty years ago in 1967. This created a new category: Medicinal Skin Care, in which sebamed is still the market leader after more than 30 years. While initially only persons with skin problems benefited from this innovation, which had rendered the soap prohibition obsolete, an altered view on skin care was slowly developing within the whole population. There was an increasing focus on skin care as a means of keeping the skin healthy and preventing skin diseases. Additionally, a growing number of people were encountering skin problems as an undesirable side effect of the regular use of increasing amounts of products, which impair or even damage the physiological functions of the skin. It is my aim to continually optimize the efficacy and skin tolerance of sebamed products through the perpetual adaptation of their formulae to reflect state-of-the-art dermatological research acquired through close cooperation with notable, international universities, dermatologists and pharmacists during the process of product development and elaboration. To this end sebamed bestows biannually the Heinz Maurer Award for dermatological research on the skins surface and its environment. The companys principle QUALITY THROUGH RESEARCH, which has been the foundation of the brand sebamed since the very beginning, also finds its expression in the large number of scientific publications, which are summarized in this brochure to give you, the reader, an objective impression of the product performance of sebamed medicinal skin care.

photographed by J.H. Darchinger

The acid mantle of the skin


The pH value of the skin is slightly acidic
The skin surface has a slightly acidic pH. This observation made by Marchionini (1929) was confirmed by later investigations (Korting 1992). Within the Stratum corneum and the hydrolipid film the average pH value lies between 4.5 and 6.0. In the deeper layers with living cells, in the epidermis up to the Stratum granulosum, the pH reaches the neutral range. The acidic pH is not homogenously present throughout the whole Stratum corneum but localized in clearly defined domains within and in between individual corneocytes with a non-linear gradient toward the Stratum granulosum, as shown by the advanced technology of Fluorescence Lifetime Imaging (FLIM; Behne et al. 2002) The skins acid mantle average pH of 5,5 present in the Stratum corneum and the hydrolipid film, predominately in the extracellular domains with a gradient towards the viable epidermis
(Fotos were kindly provided by M.J.Behne, Department of Dermatology and Venerology University Hospital Hamburg-Eppendorf, Hamburg, Germany)

The acid mantle stabilizes the ecological balance of the skins micro-flora
The acid mantle of the skin fulfills a variety of protective functions. As early as 1938, Marchionini found a relation between the skins surface pH and its colonization with microorganisms. The commensalic resident flora of the skin: Staphylococci, Micrococcae, Propionibacteria and coryneform bacteria (Dott 1992) lives predominantly from sebum, sweat, and corneocytes. It is more or less well adapted to the slightly acidic pH. The growth optima, however, vary markedly between the different species (Lucacz 1990).
Toes 5 000 000/cm2 (coryneform, propionibacteria) Forehead/scalp 100 000/cm2 (staphylococci, micrococci, propioibacteria) Nasopharynx 10 000 000/ml (streptococci)

Non-exposed skin 500/cm2 (staphylococci, micrococci) Axilla 5 000 000/cm2 (coryneform, propionibacteria)

Hand 1 000/cm2 (staphylococci, micrococci) Perineum 5 000 000/cm2 (Gram negative bacteria, coryneforms)

Ecological areas of the microbial skin flora


(Dott, 1992)

This acid mantle was formerly thought to be created solely by sweat, sebum and metabolic products of the skin surface bacteria. New investigations also demonstrated the presence of a Na+/H+-anti-porter system in the membranes of keratinocytes and in the Stratum corneum which is expressed in the dependence of the cell differentiation and produces an acidic milieu by the exchange of H+ from the cells into the intercellular space (Hachem et al. 2005). Additionally, enzymatic processes like the liberation of free fatty acids from phospholipids by acid phospholipase A2 contribute to the establishment of the acidic pH (Fluhr et al. 2004) As a third mechanism of acidification the formation of urocanic acid derived from histidine as a breakdown product of filaggrin has been identified (Krien and Kermici, 20001). Free fatty acids produced by hydrolysis of sebum lipids by lipases from species of the skin resident flora are also acidifiers of the Stratum corneum (Bibel et al, 19892) The skin shows considerable resistance against pH changes, due to the redundant sources of hydrogen ions in the Stratum corneum described above, together with the buffer capacity of fatty acids produced and the long-known lactic acid/lactate system. An impairment of the alkali neutralization capacity and even elevated Stratum corneum pH values are present in various skin diseases and physiologically in newborns whose skin surface pH drops from near neutral to slightly acidic within a few days to weeks.

Growth optima of Staphylococcus epidermidis and Propionibacterium acnes


Staphylococcus epidermidis Specific growth rate (h-1)
1,6 1,4 1,2 1,0 0,8 0,6 0,4 0,2 0,1

Propionibacterium acnes Specific growth rate (h-1)


0,2

5,0 5,5 6,0 6,5

7,0

7,5

8,0

pH

5,5

6,0

6,5

7,0

7,5 pH

(Lucacz, 1992)

Between the various organisms there exists in part antagonistic interactions like competition for room and nutrition, ammensalism by excretion of substances inhibiting the growth of other species or impairing them directly (Dott 1992). Changes in the skins surface pH lead to quantitative and qualitative alterations in the skins micro-flora (Braun-Falco, Korting 1995).

The proliferation and differentiation of the skin cells is pHdependent


In cell culture, keratinocytes require a slightly acidic milieu for optimal proliferation at pH 5.0 and 7.0, respectively, the cell growth is markedly inhibited as compared with pH 6.0. The culture medium of the keratinocytes shows an acidification with time (Soehnchen 1990). The exchange of extracellular sodium cations against intracellular hydrogen ions found by Behne et al. (1999) may explain this observation.

Cells x106

The acid mantle supports the synthesis of barrier forming lipids within the Stratum corneum
Extracellular lipids undergo various enzymatic processes after their secretion from the Odland bodies at the transition between the Stratum granulosum and the Stratum corneum, which produce hydrophobic lipids from more hydrophilic precursors, for instance, ceramides from sphingolipids. For one of the enzymes involved, -glucocerebrosidase, Mauro et al. (1998) demonstrated a higher activity at pH 5.5 as compared with pH 7.4. Recovery of the barrier function after experimental impairment by lipid extraction from the skin with aceton in vivo as measured by an initial rise in transepidermal water loss (TEWL) and subsequent gradual decrease back to baseline values, was markedly delayed under exposure of the skin to a buffer with pH 7.4 as compared with a buffer with pH 5.5. The formation of free fatty acids by secretory phospholipase A2 as constituents of the barrier lipids from phospholipids secreted from the lamellar bodies is also a mechanism for the maintenance of the homeostasis of the acid pH value within the Stratum corneum. The specific inhibition of this enzyme leads to both an increase in the skin pH and a disturbance of the barrier function as well as decreased cohesion of the corneocytes resulting in a decreased integrity of the Stratum corneum (Fluhr et al., 2001) Recent studies have revealed a further role of the acid mantle in maintaining Stratum corneum cohesion and integrity and, on the other hand, the desquamation process through attenuation of the activity of serin proteases and probably also other enzymes involved in the break-down of corneodesmosomes. Increase in Stratum corneum pH inhibits some of the enzymes involved while acitvating others, leading to irregular desquamation and decreased Stratum corneum integrity and cohesion (Hachem et al., 2005). Besides the bilammellary lipid sheets, this feature may play a major role for the skins barrier function. The role of the pH for the skin barrier function has recently been repeatedly reviewed (Elias 2005; Lee, Jeung, Ahn, 2006; Schmid-Wendtner, Korting 2006; Korting, Schmid-Wendtner 2007)

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Keratinocyte growth at different pH levels

10 Constant pH 6,0

pH 6,0

5 pH 7,0 pH 5,0

10

12

14

(Soehnchen, 1992)

The acid mantle stabilizes the barrier structures of the Stratum corneum lipids
The bilamellary structure of the intercellular lipids in the Stratum corneum is crucial for the skin's barrier function. Double lamellae form only at a pH range between 4.5 and 6.0, according to the findings of Osborne and Friberg (1987). At lower pH values the lipids are freely dissolved without any ordered structure. At pH values over 6.0 globular micellae form. Outside the pH range mentioned above, the barrier function of the intercellular lipids of the Stratum corneum is lost, resulting in an increased water loss from the skin and an enhanced penetration of exogenous substances to which the skin is exposed.

Role of pH 5.5 in skin barrier maintenance

Barrier lipids
pH > 6,0
Epidermis (pH 7.4): barrier lipid percursors Phospholipids Sphingolipids Glucosylceramides Cholesterolsulfate Stratum corneum (pH 5.5) lipid processing enzymes activated by acidic pH Acid Phospholipase Acid Shingomyelinase -Gluccosylcerebrosidase independent of pH Sulfatase Enzymes involved in breakdown of coreneodesmosomes Serin proteases (most active at pH 7) Cathepsin D Aspartate proteases (active at acidic pH) Cysteine proteases (active at acidic pH) barrier lipids (bilamellary structure stabilized by pH.5.5) Free fatty acids Ceramides Cholesterol

pH 5,5

pH < 4,5
Proteins of the cornified envelope (CE) Involucrin Loricrin Elafin Desmoplakin Cytostatins pancornulins/cornifins

Corneocytes/cornified envelope
Maintance of Stratum corneum integrity and cohesion Regulation of desquamation

Influence of pH on the conformation Stratum corneum lipids


(Osborne & Friberg, 1987)

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The influence of skin care on the acid mantle


Washing with soap impairs the acid mantle
Soaps: alkali salts of long-chain fatty acids by chemical definition, always form lyes in aqueous solution with pH values between 8 and 12. Acidic pH values cannot be established without loosing the surfactant activity. Even in healthy skin the alkali neutralization capacity is exhausted by a single wash process resulting in a prolonged increase in the skin surface pH (Kober 1990). This is not the case when the acidic syndet sebamed is used for washing. Repetitive washing with soap leads to a permanent though slight increase of the skin surface pH (Korting 1990). The importance of the pH in skin cleansing
change of pH value 2,5 2 1,5 1 0,5 0 Soap-free, product, pH 5.5 -0,5 -1 -5 0 30 60 90 120 150 180 minutes after washing (Kober, 1992) Soap

Even pH neutral skin cleansing influences the skin surface pH


Soap-free cleansing preparations contain synthetic detergents in short syndets as cleansing agents. Their surfactant activity, which they share with soaps, enables them to dissolve fatty soiling and thus cleanse the skin thoroughly. They have some advantages as compared with soap:

The chemical variability of the syndets is high as compared with soap. This makes it possible to adjust the skin tolerance and cleansing efficacy to the individual requirements. Syndets, unlike soaps, form no insoluble lime soaps in harsh, i.e. magnesium and calcium rich water. Thus they do not loose their foaming and cleansing efficacy and can be used economically, independent of water harshness. Probably this makes skin cleansing with syndets more skin friendly than soap in areas with harsh water (McNally et al., 1998) Syndets do not form lyes. The pH of syndet cleansers can be adjusted freely within a broad range. Usually, the pH is adjusted to a neutral or to the physiological, slightly acidic value of 5.5. When an alkaline syndet (pH 8.5, same composition of sebamed Liquid Face & Body Wash, except for pH) is used for skin cleansing, the acid mantle is disturbed in a similar way as by an alkaline soap (Zienicke 1992).

Change of skin pH after washing with alkaline soap and an acidic syndet Long-term course of the mean forearm pH following the use of a soap and of a soap-free cleansing product with pH 5.5 (sebamed Liquid Face & Body Wash) subsequently in a crossover design
pH value of the skin surface 6

5,5

soap syndet

Change of skin pH after washing with alkaline vs. an acidic syndet preparation Change of skin pH surface pH after wasswitch in cleansing preparation 6,0 hing with two syndet preparations of iden tical composition, 5,5 differing only in their pH (5.5 and 8.5, respectively)
5,0

syndet soap 5

4,5 0 1 2 3 4 5 6 7 8 weeks

12 3

10

17

24

31

38

45

52

59

Time days

pH 5.5 during the first 4 weeks, followed by pH 8.5 pH 8.5 during the first 4 weeks, followed by pH 5.5

(Korting et al., 1997)

(Zienicke, 1992)

12

13

Change of skin surface pH after washing with two syndet preparations of identical composition, differing only in their pH (5.5 and 7.0, respectively) Even a pH-neutral syndet (pH 7.0, composition equal to sebamed Liquid Face & Body Wash, except for pH) leads to an increase of the skin surface pH. It falls back to the initial level much more slowly than after washing with the original sebamed Liquid Face & Body Wash with its pH 5.5 (Korting 1991).
pH
6.2 6

Influence of the pH value on the dehydration of the skin


After washing the skin hydration first increases by an up-take of water resulting in skin swelling. The degree of this increase depends on various factors like the duration of the water exposure, the temperature, the pH value, and the quality and quantity of the cleansing agents applied. A comparison of cleansing preparations of different pH showed a minimal swelling at a slightly acidic pH. This is paralleled by structural damage to the epidermis with loss of nuclei of the keratinocytes at pH values above 9 (Gehring 1992). Skin swelling has to be considered as an adverse effect of skin cleansing, even though it causes a momentary pleasantly smooth skin feeling. Skin swelling is always followed by a loss of hydration of the Stratum corneum below the initial level. The more skin lipids and moisturizing factors are removed together with soiling, the stronger is the dehydration. The loosening of the Stratum corneum barrier structures by the previous swelling processes further amplifies the dehydration, just like pH-related conformation changes of the barrier lipids. In standardized washing procedures, Gehring and Gloor (1990) found a shorter lasting and less pronounced dehydration by soap-free syndet preparations adjusted to a slightly acidic pH (4.5 and the original value of sebamed Liquid Face & Body Wash, 5.5), than at pH 7.0 or 7.5. The incubation of human skin in vitro with Isopropylpalmitate and Cetiol HE caused a structural damage of the Stratum corneum, which impairs its barrier function. This leads to a swelling, which mediates a smooth skin sensation immediately after washing but gives way to an increased dehydration later on. Hydration and dehydration after treatment with detergent solutions of different pH values corneometric skin capacitance measurements
change in water content of the skin (relative units) 10

switch in cleansing preparation


5.8 5.6 5.4 5.2 5 4.8 4.8

10

17

24

31

38

45

52

59

Time days

pH 5.5 during the first 4 weeks, followed by pH 7.0 pH 7.0 during the first 4 weeks, followed by pH 5.5

(Korting et al., 1991)

Influence of the pH value of cleansing preparations on the skins micro-flora


The bacterial count of Propionibacterium acnes, a species with a narrow growth optimum between pH 6.0 and 6.5, increased under repeated washings with soap, but decreased when sebamed Liquid Face & Body Wash with pH 5.5 was used, as shown in a cross-over study (Korting 1992). Evolution of Propionibacterium acnes counts per cm2 on the subjects foreheads during repeated applications of alkaline soap and acidic syndet in the frame of a comparative cross-over trial.
log (colony forming units) 3,5 soap syndet syndet soap

pH 5.9 pH 7.0

switch in cleansing product

2,5

pH 7.5

-2

1,5

-6
1 0 1 2 3 4 5 6 7 8 weeks

-10 0 30 60 90 120 150 180

(Korting et al., 1992)

The crucial factor for the decrease in bacterial count is the pH value, as in further tests the syndet preparation produced an increase in bacterial counts if its pH was adjusted to 7.0 or 8.5 (Zienicke 1990, Korting et al, 1990).

prewash

minutes after washing


(Gehring et al., 1991)

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Skin dehydration after washing with alkaline soap and the acidic syndet sebamed F+S Dry Skin Wash
0 30 60 90 120 150 0 syndet pH 5.5 alkaline soap semisyndet -2 -4 -6

Influence of the application of skin care products on the pH value of the skin
While the influence of the pH value of cleansing preparations on the acid mantle, the skin hydration, its barrier function, and the resident skin flora is well known, the effect of the pH value of creams and lotions has scarcely been studied yet. Skin cleansing preparations are removed almost completely from the skin surface by rinsing after a short exposure period. Skin care preparations, by contrast, are left on the skin until the next washing, which usually is performed only after several hours. All skin care products which contain water have a definite pH value in their aqueous phase. In a study by Jacobi (1954) an alkaline cream (pH 8.3) caused an increase in skin surface pH which could be observed over 75 minutes. Gehring (2000) could show that even 3 hours after the application of an alkaline cream an increased pH value was still measurable on the skin surface, whereas the same formulation adjusted to pH 5.5 did not chance the skin pH.

-10 -12 -14 -16 -18 n = 25, F: p < 0.05, all cleansing preparations adjusted to equal cleansing efficacy (Gehring et al., 1995)

Comparison of the lipid removal by washing with different products


% loss of squalen by standardized washing

60 50 40 30 20 10

Older syndet preparations often had dehydrating or even irritative effects, due to the content of cleansing agents like Sodium Lauryl Sulfate, which cause damaging lipid removal and disturb the barrier. Therefore, such syndets were predominantly used for skin diseases associated with seborrhoea. By contrast, many dermatologists still recommend soaps for dry skin. Modern syndet preparations with milder cleansing agents like sebamed Dry Skin Wash can be adjusted to the requirements of dry skin, leading to less dehydration and lipid loss than soaps.

Comparison of the hydrating effect of cream formulations differing solely in their pH Change in skin hydration
4

58,8

59

15 test persons applied cream formulations of identical composition, but with pH 4, 5.5, 7 and 8 to their forearm on 5 consecutive days. The change in skin hydration before the first and after the last application was measured. At pH 5.5, the increase was significantly higher than at pH 8.

9,4
0
syndet with pH 5.5 sebamed F+S Dry Skin Wash semisyndet soap

A re-lipidizing agent added to a cleansing formulation does not reduce skin dehydration
n=15 15 10 5 0 skin capacitance (relative units)

pH 4
-1

pH 5,5

pH 7

pH 8

untreated

(Gehring et al., 1995)

(Worret, Gehring, 2004)

Dermatological tests provided evidence that additives for re-lipidization in cleansing preparations cannot reduce dehydration or lipid loss. By contrast, standardized washing procedures with cleansing preparations which were diluted to give equal cleansing effects, resulted in more pronounced loss of water and squalen from the skin when two frequently used re-lipidizing additives were added than with the original preparation.

-5 -10 -15 -20 -25 0 30 60 90 120 150 180 min n=15 basic cleansing formulation (sebamed F+S Dry Skin Wash; dilution 1:8) basic formulation with re-lipidizing agent (5% polyethylene 7-glyeryl cocoate; dilution 1:8)

The well-established influence of the pH of skin cleansing preparations on the skin physiology supports the demand formulated by Yosipovitch and Maibach (1996) for slightly acidic skin care preparations with a pH of 5.5.

(Gehring et al., 1995)

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sebamed soap-free skin cleansers


For sensitive and problem skin dermatologically tested
For healthy total body hygiene sebamed offers a complete range of soap and alkali free cleansing products adjusted to the pH value of 5.5. Gentle and effective wash active substances combined with active treatment ingredients protect the skin from drying out. All sebamed products have a pH value of 5.5 to stabilize the skins natural protective acid mantle and strengthen its physiological barrier function.

Results of an in use test with sebamed Liquid Face & Body Wash
sebamed Liquid Face & Body wash was used daily by 30 persons for 3 weeks. Bioengineering methods were applied to measure skin function parameters, comparing skin areas washed with water only to those washed with the test product.
delta-values integrity (Baseline vs. day 21) 4
n.s.

TEWL

Corneometer

70 delta-values integrity
(mean +/ SEM) (mean +/ SEM) (mean +/ SEM)

10

delta-values integrity
day 14 baseline day 7 day 21 day 28

delta-g/m2 hr

60

50

40
baseline day 7 day 14 day 21 day 28

Delta Baseline Delta washing emulsion Delta water

forearm-washing emulsion forearm-water check-washing emulsion

forearm-washing emulsion forearm-water check-washing emulsion

(Bornkessel et al 2005)

Product range:
Cleansing Bar
An innovative soap-free, pH 5.5 cleansing formula patent pending DBGM 2006008 552.1 helps maintain the skins natural protective barrier function. Thus it minimizes dehydration and irritation whilst providing pore-deep and refreshing cleansing. Polyfructosan, amino acids, and vitamins replenish the moisture balance of the skin. Dermatological tests have proven the suitability for sensitive and problem skin as well as therapy supportive skin cleansing in skin disorders (Bayerl et. al. 2007). Package sizes: 100 g and 150 g
Ingredients: Disodium Lauryl Sulfosuccinate, Triticum vulgare starch, Palmitic Acid, Stearic Acid, Glyceryl Stearate, Cetearyl Alcohol, Talc, Sodium Lactate, Cera alba, Aqua, Lecithin, Sodium Lauroyl Sarcosinate, Cocamidopropyl Betaine, Panthenol, Inulin, Sodium Cocoyl Glutamate, Tocopheryl Acetate, Glycine, Magnesium Aspartate, Alanine, Lysine, Leucine, Benzophenone-4, Parfum, CI 47005, CI 61570, CI 77891.

Revitalizing Foam Bath

Combining mild cleansing with skin care the foam bath brings refreshment and relaxation for sensitive skin during bathing. An effective moisturizing complex containing skin-related amino acids condition the skin to safeguard its moisture balance. Allantoin makes the skin smooth. Its active organic wheat complex protect the elasticity of the skin. The pH 5.5 is adapted to the skins protective acid mantle. Skin tolerance and care efficacy are dermatologically tested. Package size: 200 ml bottle

Ingredients: Aqua, Disodium Laureth Sulfosuccinate, Sodium C14-16 Olefin Sulfonate, Sodium Laureth Sulfate, Laureth-2, Parfum, Lauryldimonium Hydroxypropyl Hydrolyzed Wheat Protein, Palmitoyl Hydrolyzed Wheat Amino Acids, Hydrolyzed Wheat Protein, Allantoin, Niacinamide, Glycine, Alanine, Lysine, Leucine, Magnesium Aspartate, Propylene Glycol, Ethoxydiglycol, Sodium Chloride, PEG-55 Propylene Glycol Oleate, CI 47005, CI 42090, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate.

Liquid Face & Body Wash

The soap-free wash emulsion with pH 5.5 is adapted to physiological protective acid mantle of the skin. Pentavitin, moisturizing vitamins and amino acids minimize dehydration and irritation (Bornkessel et al. 2005). Together with panthenol they provide a unique skin feeling. Recommended for sensitive and problem skin, suitable for therapy supportive skin cleansing in skin disorders. Package sizes: 200 ml, 400 ml, 500 ml and 1000 ml bottle with pump

Ingredients: Aqua, Sodium Laureth Sulfate, Sodium C1416 Olefin Sulfonate, Disodium Laureth Sulfosuccinate, Sodium Chloride, Laureth-2, Panthenol, Glycol Distearate, Parfum, Saccharide Isomerate, Allantoin, Niacinamide, Pyridoxine HCl, Glycine, Magnesium Aspartate, Alanine, Lysine, Leucine, Biotin, Glycerin, Sodium Lauroyl Glutamate, Sodium Citrate, Cocamidopropyl Betaine, Sorbitan Laurate, PEG-120 Methyl Glucose Dioleate, Butylparaben, Ethylparaben, Isobutylparaben, Methylparaben, Propylparaben, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, CI 47005, CI 42090.

Cleansing Shower Oil

Soap-free moisturizing and emollient shower oil with a pH of 5.5 adapted to the physiological protective acid mantle. Patented Formula DE 198 435 47 helps to alleviate dryness and irritability through its richness in oils over 50 %, especially avocado oil and lecithin keeping the skin smooth and supple. The pH value of 5.5 strengthens the skin's natural barrier function against moisture loss and irritants. Free from preservatives and colors. Adapted to the physiological protective acid mantle of the skin. Package sizes: 200 ml bottle, 500 ml bottle with pump and 500 ml refill

Ingredients: Persea gratissima oil, Lecithin, MIPA-Laureth Sulfate, Laureth-4, Paraffinum liquidum, Poloxamer 101, Cocamide DEA, Parfum, Sodium Lactate.

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sebamed skin cleansers Product range:


Fresh Shower
Soap-free shower gel with a pH value of 5.5 adapted to the physiological protective acid mantle of the skin. Gently cleanses the skin and makes it smooth and soft. Particularly suited for sensitive skin and frequent showering. Protects the skin's acid mantle and barrier function. For all skin types. For persons with dry or extremely sensitive skin the application of a skin care lotion after showering is recommended. Package sizes: 200 ml, 400 ml and 1000 ml bottle with pump
Ingredients: Aqua, Disodium Laureth Sulfosuccinate, Cocamidopropyl Betaine, Disodium Cocoamphodiacetate, Glyceryl Laurate, PEG-7 Glyceryl Cocoate, Sodium Lactate, Parfum, Niacinamide, Glycine, Magnesium Aspartate, Alanine, Lysine, Leucine, Allantoin, PEG150 Distearate, PEG-120 Methyl Glucose Dioleate, Phenoxyethanol, Sodium Benzoate, CI 61570, Butylphenyl Methylpropional, Hexyl cinnamal, Linalool, Limonene.

sebamed Feminine Intimate Wash


Two stages in a womans life
Sensitive: pH value 3.8 specific for the micro-flora balance during the child-bearing years Menopause: Adjusted to the pH value of 6.8 for optimal hygiene at the on-set of menopause

Product range:
Spa Shower
Excellent skin tolerance through a mild, soap-free, pH 5.5 skin cleansing formula provides the ideal basis for well-being during showering. Moisturizing allantoin and lactic acid supplemented with water lily extract leave the skin smooth and supple. A balanced skin care complex and high skin tolerability minimize the potential for irritation and allows frequent showering even in sensitive skin. Dermatologically tested. Package sizes: 200 ml bottle
Ingredients: Aqua, Disodium Laureth Sulfosuccinate, Cocamidopropyl Betaine, Disodium Cocoamphodiacetate, PEG-120 Methyl Glucose Dioleate, Sodium Lactate, Parfum, Nymphaea alba flower extract, Glycerin, Glyceryl Laurate, Allantoin, Butylene Glycol, Phenoxyethanol, Sodium Benzoate, CI 42090, CI 47005.

Feminine Intimate Wash pH 3.8

Clinical test of sebamed Feminine Intimate Wash pH 3.8


30 women, average age 39 years washed their genitoanal area at least once daily with sebamed Feminine Intimate Wash pH 3.8 for 30 days.

The natural presence of glycogen and lactic acid in the genital ecosystem defined the formulation of Feminine Intimate Wash pH 3.8 with the skin-related lactic acid. The natural and gentle cleansing action of Feminine Intimate Wash and its acidic pH value of 3.8 maintain the biological equilibrium of the micro-flora in this sensitive area as essential prophylactic protection against bacterial and fungal infections during the child-bearing years. The soothing antibacterial property of alpha bisabolol, the active ingredient of the medicinal plant camomile prevents irritation and cares for the skin. Aloe barbadensis activates the moisture balance of the mucous lining with its natural moisturizing capacity. sebamed Feminine Intimate Wash pH 3.8 is a gentle and effective, therapeutic supportive wash emulsion for natural intimate hygiene during the child-bearing years. Package size: 200 ml bottle

Ingredients: Aqua, Lauryl Glucoside, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Aloe barbadensis leaf gel, Bisabolol, Sodium Lactate, Hydroxypropylcellulose, Parfum, Sorbic Acid.

Assessment of cosmetic capacities:


The candidates evaluation of the product was predominantly excellent to good. Washing capacity 100% excellent to good Mildness Deodorant capacity Texture Fragrance 93% excellent to good 90% excellent to good 83% good to excellent 80% excellent to good
Piarotti, Milan 2004 (unpublished results)

Results:
No alteration of skin and mucous membranes in the application area No dryness of skin and mucous membranes Very good cleansing properties Gentle cleansing action Good deodorizing action Pleasant to use

Feminine Intimate Wash pH 6.8

At the on-set of menopause lactic acid production by vaginal latobacillae subsides with the estrogen levels, resulting in a rise in pH between 6 to 7 and possible dryness of the mucous linings. The organic derivative tenside complex provides mild cleansing to safeguard against dryness. The natural calming and regenerative capacities of the herbal extract hamamelis virginiana combined with pathenol alleviate irritation and restore the physiological environment of the vulva. Reliable therapy supportive feminine hygiene. Package size: 200 ml bottle

Ingredients: Aqua, Sodium Laureth Sulfate, Cocamidopropyl Betaine, PEG-18 Glyceryl Oleate/Cocoate, Glycerin, Propylene Glycol, PEG-55 Propylene Glycol Oleate, Parfum, Sodium Lauroyl Glutamate, Panthenol, Hamamelis virginiana bark/ leaf/ twig extract, Caramel, Sodium Citrate, Benzyl Alcohol, Phenoxyethanol, Piroctone Olamine, Potassium Sorbate, Sodium Benzoate.

In the initial development of Feminine Intimate Wash a panel of 80 female gynaecologists personally tested the efficacy and skin tolerability of the product giving high notes for tolerance, a notoiceable soothing effect and analgesic properties.

20

21

sebamed protective care products


For sensitive and problem skin
Individual and regular skin care is the skin's best defense against noxious external influences. This is why sebamed has developed special products for the face, hands, and body, with a pH value of 5.5. With their active skin care ingredients and the pH value of 5.5 they alleviate irritation and dryness, to help solve skin problems and are a useful supplement for skin therapy in skin disorders. In vivo effect of sebamed Moisturizing Cream with vs. without vitamin E on UV-induced erythema

Free-radical scavenging effect of sebamed Moisturizing Cream


Skin Blood Flow Volume (BFV)
30

Visual Scores (Erythema)


2 * 1,5 *,** *

BFV (a.u.)

20

Visual Scores (0-4)

*,**

10

0,5

Day 2

Day 3

Days

Day 2

Day 3

Days

Vitamine E emulsion Vehicle control Blank control

* p < 0,05 in comparison with blank control ** p < 0,05 in comparison with vehicle control

(Zhai et al., 2005)

Product range:
Moisturizing Cream
Moisture and emollience make the skin smooth and supple. sebamed Moisturizing Cream has demonstated its skin care efficacy and tolerance in sensitive skin through dermatological study. With its high content of 2.3% Tocopheryl acetate to counteract oxidation stress to the skin, and its pH value of 5.5 to match the physiology of the skin, the cream offers valuable cellular protection. The moisturizing complex increases the lipid content and hydration of the skin. Excellent skin tolerability in sensitive skin. Packaging size: 50 ml tube, 75 ml, 100 ml jar
Ingredients: Aqua, Petrolatum, Myreth-3 Myristate, Glycerin, Cetearyl Alcohol, Tocopheryl Acetate, Ceteareth-20, Dimethicone, Sodium PCA, Sodium Citrate, Sodium Carbomer, Parfum, Benzyl Alcohol, Phenoxyethanol.

In vitro radical scavenging effect of sebamed Moisturizing Cream with vs. without vitamin E demonstrated the efficacy of this active ingredient (Zhai et al., 2003). The benefits of the cream for skin care were further confirmed in a test on 25 women over three weeks. The state of the skin, dryness, roughness, and other symptoms were ameliorated (Sera-Baldrich et al., 2002).

In-use test of sebamed For Men After Shave Balm


3-week test with 40 men, daily use.

Suitability as After Shave

17 18 11 17 15 0 5 10 15 20

23 22

excellent good 29

For Men After Shave Balm

Calming and smoothing skin care relieves discomfort of facial skin in men with sensitive skin after shaving. sebamed After Shave Balm restores the natural barrier and defends against, dryness, irritation, and harmful bacteria or fungi with the help of its pH 5.5. Phytosterols and bisabolol relieve stinging and redness. The balm is easily applied and rapidly absorbed without residue, leaving the skin smooth and supple. Package size: 100 ml tube

Ingredients: Aqua, Octyldodecanol, C12-15 Alkyl Benzoate, Glycerin, Sorbitol, Glyceryl Stearate Citrate, Brassica campestris Sterols, Bisabolol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Menthol, Parfum, Sodium Citrate, Sodium Benzoate, Benzyl Alcohol, Phenoxyethanol.

Effect on skin irrtiation Skin tolerance Effect on the state of the skin Skin care effect

23 25 25 30

(Worret, 2006, unpublished data)

22

23

Moisturizing Body Lotion

Moisturizing oil-in-water emulsion with a pH value of 5.5. A lotion for sensitive skin. Its stabilizing effect on the barrier function and its active moisturizing ingredients make the skin soft and smooth. Olympic athletes have found the lotion effective against skin problems resulting from high levels of perspiration and in preventing skin dryness. Soaks in rapidly and completely after the application without any greasy residue. Package size: 200 ml and 400 ml bottle

Ingredients: Aqua, Cetearyl Alcohol, Glycerin, Sorbitol, Paraffinum liquidum, Sodium Lactate, Decyl Oleate, Chamomilla recutita, Lecithin, Ascorbyl Palmitate, Allantoin, Caprylic/Capric Triglyceride, Sodium Cetearyl Sulfate, Dimethicone, Sodium Citrate, Parfum, Alcohol, Methylparaben, Phenoxyethanol, Propylparaben.

Hand + Nail Balm

Moisturizing oil-in-water balm for stressed hands and nails, with a pH-value of 5.5. The balm moisturizes dehydrated hands and nails, while the pH value of 5.5 stabilizes the skin's barrier function and acid mantle, thus protecting it from environmental noxes. Furthermore, the pH value of 5.5 stabilizes the nail structure. The quick and complete absorption of the balm by the skin encourages its regular use at home and at work. Package sizes: 75 ml

Ingredients: Aqua, PPG-2 Myristyl Ether Propionate, Hydrogenated CocoGlycerides, Glycerin, Glyceryl Cocoate, Hydrogenated Coconut Oil, Sorbitol, Ceteareth-25, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Panthenol, Allantoin, Hydrolyzed Keratin, Bisabolol, Sorbitan Oleate, Caprylyl/Capryl Glucoside, Polyisobutene, Sodium Citrate, Parfum, Phenoxyethanol.

In-use test of sebamed Hand + Nail Balm Body Milk


Moisturizes and protects dry skin, an oil-in-water emulsion with a pH value of 5.5. Intensive body care with shea butter and jojoba oil to moisturize and smooth the skin without leaving a greasy film. Glycerin and the pH value 5.5 support the skin's acid mantle and barrier function. D-Panthenol supports regeneration and helps to regain the moisture balance of dry skin. Clinical tests demonstrated a 26% increase in skin hydration. Package size: 200 ml bottle
Ingredients: Aqua, Hexyldecanol, Hexyldecyl Laurate, Glyceryl Stearate, Glycerin, Panthenol, Petrolatum, Simmondsia chinensis, Butyrospermum parkii, Ceteareth-20, Cetyl Palmitate, Cetearyl Alcohol, Ceteareth-12, Sodium Carbomer, Sodium Citrate, Parfum, Phenoxyethanol, Benzyl Alcohol.

Dermatological in-use test in 28 employees and patients of the dermatological clinic of the Potsdam University over 3 weeks with repeated daily use of the Hand & Nail Balm.

140 130 120 110 100 90 80 start 1 2 3 weeks

Increase in skin hydration

In-use test of sebamed Body-Milk


3 week in-use test in 30 persons with dry skin. Measurement of hydration at least 10 hours after the last application of sebamed Body Milk after 2 weeks of daily use
50

(Niedner, 1995, unpublished data)

Skin hydration (Corneometer values)


normal skin dry skin

after 2 weeks 48

Anti-Swelling Hand Balm

45

40

before use of Body Milk 38

(Greif et al., Kosmetische Medizin 1998)

An innovative and patented product Patent No. EP 1364651 B1 was designed to reverse skin swelling after wet work and wearing of occlusive gloves. As skin swelling is a well-established predisposing factor for hand eczema in occupational as well as in household, sports, and other private settings, a solution is urgently needed. The active ingredient Dehydrosal restores normal hydration levels and the barrier function within minutes afer application. Regular use of sebamed Anti-Swelling Hand Balm after wet work or glove removal also reduces and prevents irritation. Package sizes: 100 ml with pump

Ingredients: Aqua, Prunus dulcis oil, Steareth-2, Aluminium Chlorohydrate, C12-15 Alkyl Benzoate, Butyrospermum parkii butter, Steareth-21, Tocopheryl Acetate, Sodium Aluminium Chlorhydroxy Lactate, Sodium Citrate, Parfum, Benzyl Alcohol, Phenoxyethanol.

Derma Hydrating Body Gel

The light oil-free texture of Derma Hydrating Body Gel is rapidly absorbed by the skin and non-occlusive, leaving the skin soft, smooth and refreshed. Derma Hydrating Body Gel provides immediate soothing regeneration and restores the moisture balance of the skin. The skin is refreshed and revitalized. Its pH value of 5.5 supports the maintenance of the skins acid mantle and its vital protective capacity. The high skin tolerability of Derma Hydrating Body Gel relieves skin irritation after shaving and depilation. For problematic skin, which does not tolerate oils and emulsifiers this light gel is suitable for balancing, hydrating care of the skin. In a dry skin condition Derma Hydrating Body Gel can be used as an additional basic hydrating treatment before sebamed Body Milk in aiding the skin to regain its equilibrium. Package size: 200 ml and 500 ml bottle with pump

Ingredients: Aqua, Aloe barbadensis leaf gel, Propylene Glycol, Glycerin, Sorbitol, Betaine, Panthenol, Sodium Hyaluronate, Allantoin, Sodium Citrate, Sodium Carbomer, Caprylyl/Capryl Glucoside, Parfum, Phenoxyethanol, Sodium Benzoate, CI 42090, CI 47005.

In-vitro test of deswelling efficacy of Dehydrosal


Comparison of the anti-swelling effect of Dehydrosal and other active ingredients in frozen sections of human skin after incubation with Sodium Laurylsulfate

(Gehring 2006)

24

25

sebamed hair care system


For sensitive scalp and hair problems
A sensitive and problematic scalp as well as structurally damaged hair require special care. The pH value of 5.5 of the sebamed hair care system supports the physiological acid mantle of the scalp and the barrier function against dehydration, penetration of irritants, and pathogenic microorganisms. It also strengthens the keratin structure of the hair.

Repair Shampoo

sebamed Repair Shampoo was developed specially for structurally damaged hair. Structural damage can be caused by perming, coloring, styling, hot blow-drying and sun. sebamed Repair Shampoo contains a highly effective repair complex of plant-based active ingredients to cleanse, moisturize and protect hair and scalp. Biopolymers encase the hair shaft with a micro-film to protect the hair and restore structural damage. Natural protein and moisturizers regulate the moisture balance of the hair and scalp. The pH value of 5.5 stabilizes hair and scalp. Package size: 200 ml and 400 ml bottle

Ingredients: Aqua, Disodium Laureth Sulfosuccinate, Sodium C14-16 Olefin Sulfonate, Sodium Laureth Sulfate, Laureth-2, CocoGlucoside, Glyceryl Oleate, Sodium PCA, Hydrolyzed Soy Protein, Hydroxypropyl Guar Hydroxypropyltrimonium Chloride, Lauryldimonium Hydroxypropyl Hydrolyzed Wheat Protein, Palmitoyl Hydrolyzed Wheat Amino Acids, Hydrolyzed Wheat Protein, Glycerin, Sodium Lactate, Parfum, Ethoxydiglycol, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate.

Efficacy of sebamed Repair Shampoo on hair and scalp In-use test in 25 persons with dry hair and scalp
% change in evaluated average scores within 3 weeks of regular use of sebamed Repair Shampoo
Ingredients: Aqua, Decyl Glucoside, Disodium Laureth Sulfosuccinate, Sodium Lauryl Sulfoacetate, PEG-55 Propylene Glycol Oleate, Propylene Glycol, Hydroxypropyl Oxidized Starch PG-Trimonium Chloride, Sodium Citrate, PEG-18 Glyceryl Oleate/Cocoate, Parfum, Phenoxyethanol, Sodium Benzoate.

0 -10 -20 -30 -40

Product range:
Everyday Shampoo
Contains a sugar-based tenside agent and an active moisturizing compound for specially gentle cleansing action to protect and stabilize the hairs structure and the health of the scalp. With a pH value of 5.5 for prevention of hair and scalp dehydration and strengthening of the physiological acid mantle. High skin tolerabilitiy for frequent hair washing even with a sensitive scalp or by dry and damaged hair. Package sizes: 200 ml and 400 ml bottle and 1000 ml bottle with pump

-37% -47%
scalp irritation

-50
dryness of hair

-49%
dryness of scalp
(Treb, Zrich 2005, unpublished data)

Anti-Dandruff Shampoo

Gently and thoroughly cleanses oily dandruff prone scalp. Effectively combats the proliferation of dandruff causing Pityrosporum ovale for immediate relief of scalp irritation. The high tolerability and efficacious dandruff control properties of its active ingredient Piroctone Olamine dislodges dandruff gently and reliably so that the skin can breath. Combined with a mild sugar surfactant complex allows for regular use. The mild, pH 5.5 cleansing formula rinses off excess oil without causing dryness or irritation of the scalp. Package sizes: 200 ml and 400 ml bottle and 1000 ml bottle with pump

Ingredients: Aqua, Sodium Laureth Sulfate, Lauryl Glucoside, Sodium Lauroyl Sarcosinate, Sodium Chloride, Sodium Lactate, Hydroxypropyl Oxidized Starch PG-Trimonium Chloride, Piroctone Olamine, Glycol Distearate, Cocamidopropyl Betaine, Laureth-4, Parfum, Phenoxyethanol, Sodium Benzoate.

Hair Repair Conditioner

Moisturizing Panthenol and Hydrolyzed Silk together with selected plant extracts give the hair a healthy shine and make it easier to style. Particularly suitable for dry, damaged hair. To be used after washing of the hair and rinsed off before drying and styling. Package size: 200 ml bottle

Ingredients: Aqua, Cetearyl Alcohol, Propylene Glycol, Amodimethicone, Panthenol, Persea gratissima oil, Hydrolyzed Silk, Foeniculum vulgare fruit extract, Humulus lupulus extract, Melissa officinalis leaf extract, Viscum album leaf extract, Chamomilla recutita flower extract, Achillea millefolium extract, Sodium Lactate, Sodium Cetearyl Sulfate, Ceteareth-12, Cetyl Alcohol, Cetrimonium Chloride, Polyquaternium-16, Parfum, Alcohol denat., Trideceth-12, Sodium Benzoate.

26

27

sebamed Deodorants for sensitive skin


Natural, gentle, safe
Supression of body odour forming bacteria by active ingredients and pH 5.5 provide reliable, long-lasting protection from unpleasant body odour without interfering with the function of the sweat glands. All sebamed deodorants are free from aluminium salts to provide maximum skin tolerance.

Balsam Deodorant

An extra-mild skin care formula to protect even the most sensitive skin from body odour without irritation. The active formula trisoft combines an inhibitor of odour-causing bacteria with an odour absorbent agent and the protective lipid squalane. Talc absorbes moisture. Dermatologically tested. Package sizes: 50 ml roll-on

Ingredients: Aqua, Talc, Squalane, Caprylyl Glycol, Zinc Ricinoleate, Parfum, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Malate, Disodium EDTA.

Clinical in-use test of sebamed Balsam Deodorant sensitive


30 test persons with sensitive skin according to a facial stinging test with 10% lactic acid used the deodorant daily for 3 weeks in the armpits and on the left forearm, the right forearm was left untreated to serve as a control. Measurements of skin hydration, surface lipids, TEWL and pH were performed on the forearm skin as the axillae yields no reliable data. There was no difference between untreated and deodorant-treated skin in term of barrier function (TEWL), hydration and pH, indicating an excellent skin compatiblity of the product, whereas an increase in skin surface lipids proved an emollient effect.

Product range:
24 h Care Deodorant
The first deodorant with a trilipid formulation for the best skin tolerability. Gentle, reliable protection from body odour 24 hours, with allantoin to protect and smooth the skin. Free from alcohol and aluminium salts. Scent: lime. Package sizes: 75 ml pump spray, 50 ml roll-on
Ingredients: Spray: Aqua, Polysorbate 20, Triethyl Citrate, Sodium Citrate, Candida bombicola/Glucose Methyl Rapeseedate Ferment, Pentylene Glycol, Sorbitol, Allantoin, Parfum, Phenoxyethanol.ethanol Roll-on: Aqua, Polysorbate 20, Triethyl Citrate, Sodium Citrate, Candida bombicola/Glucose Methyl Rapeseedate Ferment, Allantoin, Pentylene Glycol, Xanthan Gum, Parfum, Phenoxyethanol.

Change in transepidermal water loss (TEWL)


10 left forearm with deodorant right forearm without deodorant

TEWL (g/cm2xh)

Fresh Deodorant

Prevents body odor without affecting the natural function of the sweat glands. Gentle enough for sensitive skins. For all skin types. Free from aluminium, colors and preservatives. Scent: fresh, active, blossom. Package size: 75 ml pump spray, 50 ml roll-on

Ingredients: Spray: Alcohol, Aqua, Triethyl Citrate, Parfum, Sodium Citrate. Roll-on: Aqua, Alcohol, Triethyl Citrate, Parfum, Hydroxypropylcellulose, Sodium Citrate.

6 0 1 2 3

weeks

(Keil, Jung, Bayerl, 2002)

For Men Balsam Sensitive

Without aluminium salts, without alcohol. 24 h protection from body odour with superior skin tolerance for sensitive skin is achieved by combining an anti-bacterial active ingredient with an odour absorber and the emollient squalane. Dermatologically tested by men with sensitive skin. Package size: 50 ml roll-on

Ingredients: Aqua, Talc, Squalane, Caprylyl Glycol, Zinc Ricinoleate, Parfum, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Malate, Disodium EDTA.

28

29

Baby sebamed
The best protection from the very first day
Baby skin is extremely sensitive and dehydrates easily due to its loose and soft structure. The protective acid mantle develops during the first weeks of life, but remains less stable and resistant until adolescence. Microbial colonization of the skin by apathogenic species is controlled by the acid mantle, which thus prevents skin infections. Therefore, baby requires cleansing and skin care formulated with a pH value of 5.5, highly efficient moisturizers for emollients, and maximum skin tolerance.

Baby Bubble Bath

The extra mild soap and alkali free tenside complex combines with emollients, moisturizers, and soothing chamomile to provide gentle cleaning for sensitive baby skin and protect it from dryness and irritation. To be added to the baby bath after the navel has healed. Dermatologically tested. Package size: 250 ml, 500 ml

Ingredients: Aqua, Cocamidopropyl Betaine, Sodium Laureth-6 Carboxylate, Disodium Cocoamphodiacetate, Sodium C14-16 Olefin Sulfonate, Chamomilla recutita extract, Sodium Lactate, Glyceryl Laurate, Propylene Glycol, PEG-55 Propylene Glycol Oleate, PEG-18 Glyceryl Oleate/Cocoate, Alcohol, Parfum, Phenoxyethanol, Sodium Benzoate.

The incidence of dry skin in the panel decreased in favor of normal skin during the use of the bubble bath, as did clinical scores for skin symptoms: eyrthema 57%, tension 90 %, dryness 57%, flaking 67%, stinging 81%, papules/pustules 54%. Skin surface lipids increased markedly while pH remained constant, and hydration decreased slightly over the observation period.

Dermatological in-use test of Baby sebamed Bubble Bath

Product range:
Baby Cleansing Bar
cleansing bar Patent Pending: DBGM 2006 008 551.1 with an amino acid based surfactant compound of sodium lauroly sarconsinate and cocamidopropyl betaine combines with the natural skin-related oligosaccharide inulin for the gentle cleansing of babys delicate skin. A moisturizing and skin care complex with panthenol and lecithin protect further against dehydration. The pH value of 5.5 supports the development of the still instable acid mantle, during the early stages in life. Package size: 100 g and 150 g
Ingredients: Triticum vulgare starch, Disodium Lauryl Sulfosuccinate, Palmitic Acid, Stearic Acid, Glyceryl Stearate, Cetearyl Alcohol, Talc, Aqua, Sodium Lauroyl Sarcosinate, Cocamidopropyl Betaine, Sodium Lactate, Cera alba, Panthenol, Inulin, Lecithin, Glycine, Magnesium Aspartate, Alanine, Lysine, Leucine, Parfum, CI 77891.

Test in 30 children (age 8 20 months) with skin problems (atotpc dermatitis, xerosis, diaper rash, seborrhoic dermatitis of the scalp etc.) over a 4 week period of use

35 30 25 20 15 10 5 0

32 26

dry normal 16

14 7 3
Initial Intermitted examination examination

Final examination

(Molnar et al. K, in preparation)

Baby Wash extra soft

A newly developed, soap-free, pH 5.5 formula reduces the drying and irritating effects of cleansing on sensitive baby skin. Panthenol, Squalane (a vernix related lipid) and vitamin E substitute moisture lost by cleansing, creating a soft and supple skin feeling. To be used for washing from head to toe from the very first day. Package size: 200 ml and 400 ml with pump

Ingredients: Aqua, Decyl Glucoside, PEG-7 Glyceryl Cocoate, Disodium Laureth Sulfosuccinate, Sodium Laureth-6 Carboxylate, PEG120 Methyl Glucose Dioleate, Sodium Lactate, Allantoin, Squalane, Magnesium Sulfate, Parfum, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate.

Childrens Shampoo

For the delicate scalp and fine hair of babies and children from birth to adolescence. The pH value of 5.5 promotes the development of the scalps physiological acid mantle. A 100% soap and alkali free mild emollient formula for excellent skin tolerance. Package size: 150 ml and 250 ml bottle and 500 ml bottle with pump

Ingredients: Aqua, Cocamidopropyl Betaine, Sodium Methyl Cocoyl Taurate, Disodium Cocoamphodiacetate, Chamomilla recutita extract, Sodium Lactate, Glycol Distearate, PEG-120 Methyl Glucose Dioleate, Laureth-4, Alcohol, Parfum, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate.

30

31

Protective Facial Cream

The pleasantly light oil-in-water emulsion efficiently protects the sensitive facial skin of the baby against dryness and irritating environmental influences without occlusive effects. Vitamine E, Panthenol, Squalane, Allantoin and hyaluronic acid combine to keep the skin soft and supple and relieve dryness or irritation. Package size: 100 ml pump container

Ingredients: Aqua, Cetearyl Alcohol, Cetyl Palmitate, Glycerin, C12-15 Alkyl Benzoate, Propylene Glycol Dicaprylate/Dicaprate, PEG-20 Methyl Glucose Sesquistearate, Tocopheryl Acetate, Panthenol, Squalane, Sodium Hyaluronate, Allantoin, Sodium Cetearyl Sulfate, Methyl Glucose Sesquistearate, Sodium Citrate, Dimethicone, Sodium Carbomer, Parfum, Phenoxyethanol, Sorbic Acid.

Body Milk

The 23% natural lipid complex of sweet almond oil, shea butter, skin-related squalane and lecithin is easily absorbed by the skin to promote its hydrolipid balance without harmful occlusive effects. Allantoin and a high concentration of panthenol actively regulate the skins moisture content, regenerating the skin to counteract irritation, and make babys skin soft and smooth. Dermatologically/clinically tested. Package size: 200 ml bottle

Ingredients: Aqua, Prunus dulcis oil, Propylene Glycol Dicaprylate/Dicaprate, Panthenol, Glycerin, Butyrospermum parkii butter, Polyglyceryl-3 Methylglucose Distearate, Squalane, Lecithin, Allantoin, Ascorbyl Palmitate, Caprylic/Capric Triglyceride, Sodium Citrate, Sodium Carbomer, Parfum, Benzyl Alcohol, Phenoxyethanol.

In-use test of Baby sebamed Protective Facial Cream


sebamed Baby Facial Cream was tested in a dermatological practice on 20 children between 5 months and three years of age in summer 2005. The cream was applied once or twice daily on the face for 3 weeks. Change in transepidermal water loss 15 Sebamed Baby Wash was tested together with sebamed Baby Body Milk on 30 babies at the Pediatric Clinic of the Vienna University by Prof. Braun for 3 weeks. The Pediatrician, the nurses, and the parents evaluated the products. very dry 5 normal oily

In-use test of sebamed Baby Wash extra soft and Baby Body-Milk
30 number of babies 25 20 15 10 5 0
before use after 1 week after 2 weeks after 3 weeks
3 0 0 0 0 0 0 0 0 15 12 7 6

Body Skin
23 24

28

TEWL (g/cm2 x h)

10

cheek

forehead

dry

30 number of babies 25 20 15 10 5 0

Facial Skin
20

30 26 28

3 weeks

8 4 2 0 0 0 0 0 0 0 0 0

(Keil D, unpublished study 2005)

before use

after 1 week

after 2 weeks after 3 weeks

(Dermatological in-use test by Prof. Braun, Vienna, 1999)

Diaper Rash Cream Baby Cream extra soft


For the intensive protection of babys sensitive skin, this rich water-in-oil emulsion with 42% lipids forms a protective and moisturizing film, without occlusive effects. Well suited for the prevention of nappy rash dermatitis, the active ingredient panthenol stimulates the healing process. Package size: 50 ml, 200 ml and 300 ml tube
Ingredients: Aqua, Petrolatum, Paraffinum liquidum, Hydroxyoctacosanyl Hydroxystearate, PEG45/Dodecyl Glycol Copolymer, Methoxy PEG-22/Dodecyl Glycol Copolymer, Sodium Lactate, Panthenol, Allantoin, Chamomilla recutita extract, Xanthan Gum, Parfum, Phenoxyethanol, Alcohol.

Strongly indicated for skin conditions effecting the nappy area, providing rapid relief and reliable pprotection in mild forms of nappy dermtitis, exept for superinfected forms. The 36% lipid compound including lecithin, which is part of the skins hydrolipid system and skin-related squalane help to create a protective barrier against aggressive substances. Package size: 100 ml and 200 ml tube

Ingredients: Aqua, Petrolatum, Paraffinum liquidum, Polyglyceryl-2Sesquiisostearate, Panthenol, Cera alba, Sorbitol, Squalane, Titanium Dioxide, Dimethicone, Triticum vulgare extract, Lecithin, Ascorbyl Palmitate, Allantoin, Sodium Lactate, Cera microcristallina, Caprylic/Capric Triglyceride, Sodium Citrate, Disodium EDTA, Parfum, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate, Sorbic Acid.

Baby Lotion

The moisturizing and emollient complex with 7% lipids safeguards the delicate baby skin against dryness. It is rapidly absorbed by the skin without greasy residue. Glycerin, propylene glycol and sorbitol enhance the skins hydrolipid balance. Package size: 200 ml and 400 ml with pump

Ingredients: Aqua, Cetearyl Alcohol, Glycerin, Sorbitol, Paraffinum liquidum, Sodium Lactate, Decyl Oleate, Chamomilla recutita extract, Lecithin, Ascorbyl Palmitate, Allantoin, Caprylic/Capric Triglyceride, Sodium Cetearyl Sulfate, Dimethicone, Sodium Citrate, Parfum, Alcohol, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate.

Soothing Massage Oil

Pure oil based on soy and plant lipids together with wheat germ extract provides smoothing an protective skin care. The oil is formulated to allow sufficient gliding properties for gentle baby skin massage to combine the products care acitivities with the well-established beneficial effects of massage. Package size: 150 ml bottle

Ingredients: Glycine soja oil, Oleyl Erucate, CocoCaprylate/Caprate, Hexyl Laurate, Parfum, Triticum vulgare extract.

32

33

Amelioration of erythema and roughness in childrens skin by Baby sebamed Cream Extra-Soft
Test in 80 children aged 9 months to 6 years after medication or for skin care alone
Skin care after medication Reduced erythema: Chromameter values for redness
50

sebamed Clear Face


Therapy supportive skin care for acne-prone skin
Adequate skin care is crucial. In mild cases it is able to prevent the formation of non-inflammatory lesions and as a consequence the development of papules and pustules, or support their rapid healing. More severe cases profit from therapy supporting skin care by avoiding dryness and irritation and adding to the treatment success.

15

Reduced roughness Profilometric roughness values

12

40

30

20

10

0
before cream application after 4 weeks after 8 weeks

0
before start of skin care after 4 weeks after 8 weeks

Product range:
Baby sebamed Cream extra soft untreated

Cleansing Bar

Need for skin care due to e.g. atopic eczema Reduced erythema Chromameter values for redness
6,6 6,4 25 6,2 6 5,8 5,6 10 5,4 5,2 5
before skin care after 4 weeks after 8 weeks

New soap free amino acid based formula Patent Pending: DBGM 2006 008 551.1 with Inulin for effective deep cleansing of combat pimples, blackheads and skin impurities. Removes excess oil without causing dryness or irritation in sensitive acne skin and helps reduce acne lesion. Vitamins, amino acids and active moistureres help to rebalance the moisture content of the skin. Package size: 100 g

Ingredients: Disodium Lauryl Sulfosuccinate, Palmitic Acid, Stearic Acid, Triticum vulgare starch, Glyceryl Stearate, Cetearyl Alcohol, Talc, Aqua, Sodium Lactate, Sodium Lauroyl Sarcosinate, Cocamidopropyl Betaine, Parfum, Inulin, Lecithin, Cera alba, Tocopheryl Acetate, Glycine, Magnesium Aspartate, Alanine, Lysine, Leucine, CI 77891.

Reduced roughness Profilometric values for roughness


30

Antibacterial Cleansing Foam

20

15

Thorough cleansing without dehydration with the patented active ingredient Montaline C40 which has an antibacterial effect. High skin tolerability ensures gentle pore deep cleansing to remove excessive sebum, dequamation and dirt particles. Adjusted to the skins natural pH value of 5.5 to support the biological barrier function of the acid mantle Panthenol hydrates the skin and supports the healing of skin lesions. The reduction of comedones and inflammatory lesions has been demonstrated in a dermatological test. Package size: 150 ml bottle with pump applicator

Ingredients: Aqua, Cocamidopropyl Betainamide MEA Chloride, Cocotrimonium Methosulfate, Sodium Lactate, Panthenol, Parfum, Phenoxyethanol.

0
before skin care after 4 weeks after 8 weeks

(Budde et al., 1989)

34

35

sebamed Clear Face Antibacterial Cleansing Foam reduces acne lesions


30 test persons with acne used sebamed Clear Face Cleansing Foam for daily facial cleansing for 4 weeks. The number of lesions per half side of the face were counted

Care Gel

closed comedones
30 25 20 15 10 5 0 initial after 4 weeks

open comedones
30 25

25,5 18,9 16,5

20,5 14,1 13,6

20 15 10 5 0 initial after 4 weeks

A mild gel for problem skin and for persons with acne, showing comedones, acne papules , and pustules, with a pH value of 5.5. Although acne skin produces too much sebum it is often dry, tight, coarse and flaky. The oil compounds in creams and lotions encourage the development of blackheads and pimples. sebamed Clear Face Care Gel contains allantoin, hyaluronic acid and aloe to smooth, relax and calm the distressed skin. Panthenol clears up inflammation quickly. The pH value of 5.5 naturally protects against the proliferation of acne bacteria. Free from oils, emulsifiers and colorants. Package size: 50 ml tube.

Ingredients: Aqua, Aloe barbadensis leaf gel, Propylene Glycol, Glycerin, Sorbitol, Panthenol, Sodium Hyaluronate, Allantoin, Sodium Carbomer, Sodium Citrate, Phenoxyethanol, Sorbic Acid.

papules
8

pustules
5 4

7,2

4,5

Anti-Pimple Gel

4,4
4

2 2

1,7

1,3

Through direct application to inflammatory lesions its anti-bacterial effect accelerates the healing process markedly. The anti-bacterial effect of chloroxylenol and alcohol eliminates the inflammatory stimulus. Witch hazel extracts and bisabolol reduce the inflammation, and allantoin in combination with panthenol support the healing process. Cucumber extract and hydrolyzed silk hydrate and smooth the skin. Package size: 10 ml tube.

Ingredients: Aqua, Alcohol, Glycerin, Polysorbate 20, Propylene Glycol, Panthenol, Bisabolol, Allantoin, Hamamelis virginiana bark/ leaf/ twig extract, Hydrolyzed Silk, Cucumis sativus fruit extract, Chloroxylenol, Caramel, Sodium Citrate, Sodium Carbomer, Parfum, Potassium Sorbate, Sodium Benzoate.

0 initial after 4 weeks

0 initial after 4 weeks

(Keil, Jung, Bayerl 2002)

Coloured Anti-Pimple Cream Deep Cleansing Toner


Pore-deep cleansing for the removal of excess sebum and bacteria. Natural protection against pimples with the pH value of 5.5. The toner removes excess sebum thoroughly. The acne bacteria are inhibited by the pH value of 5.5 and the alcohol content of the toner. The active natural skin care ingredients - cucumber extract and hydrolyzed silk - protect against dryness. Allantoin and witch hazel smooth and calm the skin. Panthenol supports the skins regeneration. Package size: 150 ml bottle
Ingredients: Aqua, Alcohol, Panthenol, Polysorbate 20, Glycerin, Propylene Glycol, Sodium Lactate, Allantoin, Hamamelis virginiana bark/ leaf/ twig extract, Hydrolyzed Silk, Cucumis sativus fruit extract, Hydroxypropyl Oxidized Starch PG-Trimonium Chloride, Caramel, Parfum, Sodium Benzoate, Potassium Sorbate, CI 42090.

Camouflages irritation and offers effective relief from pimples. Reduces inflammation and dries out pimples. Panthenol and allantoin support the regeneration of the skin. The pH value of 5.5 stabilizes the acid mantle to combat pimple causing bacteria, preventing the development of new pimples. Package size: 10 ml tube.

Ingredients: Aqua, C12-15 Alkyl Benzoate, Glyceryl Stearate SE, Butyrospermum parkii butter, Pentylene Glycol, Alcohol, Cetearyl Alcohol, Sorbitol, Brassica campestris Sterols, Squalane, Simmondsia chinensis oil, Tocopheryl Acetate, Behenyl Alcohol, Panthenol, Cetearyl Glucoside, Sodium Citrate, Xanthan Gum, Chloroxylenol, Parfum, CI 77891, CI 77491, CI 77492, CI 77499.

36

37

sebamed sun care


Triple protection for the skin
In the sun the skin absorbs vitamin D and reacts to UV exposure positively through the thickening of the Stratum corneum, which strengthens its resistance to environmental influences and promotes melanin synthesis. However the powerful UV rays of the sun can also cause irreparable injury to the skin through damage of the DNA, lipids and proteins in the cells and tissue; producing sunburn, sun allergies and increasing the risk of skin cancer. The skin absorbs UV-A (long-wave ultraviolet radiation) and UV-B rays (short-wave ultraviolet radiation) and this is where the highly effective sun filters of sebameds waterproof sun care products offer the best possible protection. All sun care products are readily absorbed by the skin and formulated with the pH value of 5.5 to protect the health of the skins acid mantle. Dry skin is a common skin problem with symptoms of tightness, roughness, scaling and which irritation, require special skin care. Independent of the cause, like genetic disposition for sebostasis, age hormones, skin diseases like atopic eczema or psoriasis, systemic diseases like diabetes, or medications affecting the skin like chemotherapy, sebamed Anti Dry offers a compelte program for uniquely mild cleansing, facial care and body care with phytosterols from rapesseed oil, which combine emollience with anti-inflammatory efficacy. All products are clinically and dermatologically tested. Suitable for children.

sebamed Anti-Dry
Regenerates dry skin, recommended therapy supportive skin care for atopic dry skin

Highly effective sun filters absorb the harmful UVA and UVB rays Vitamin E neutralizes free radicals to protect against premature aging and sunburn Highly effective moisturizing complex protects the skin, preventing dehydration Water resistant sun screens: All sebamed sun care products are water-proof. Sweating and bathing removes filter substances and pigments from the skin, decreasing the SPF. For this reason sebamed Sun Care has a special water-proof formula, which builds a protective film. However by prolonged water contact the sun protection is ultimately reduced. For this reason, it is important to reapply the sun care product. Rules for using sun screens: Sun lotions or creams should be applied 15 - 20 minutes prior to UV exposure. Reapplication after 150 minutes, or directly after extensive bathing and towel drying is necessary to maintain the labelled SPF. The adequate SPF should be chosen according to the individual skin type and exposure time. A special note: Children under 1 year of age should not be exposed to the sun. For older children, sebamed Sun Cream SPF 28 is recommended.

Dermatological test of the sebamed Anti-Dry product range in 20 children suffering from atopic eczema
% 30 20 10

35

30

23
Change in skin barrier function

Dermatologists concluded that the products are highly recommendable for dry, sensitive, and irritated childrens skin.

Change in skin hydration

Change in skin surface lipids

(Maas, Klinik Norddeich, 2006 unpublished study)

In-use test of sebamed Anti Dry range in diabetic patients


Diabetes is associated with dry skin. The sebamed Anti-Dry products range was evaluated in 17 patients suffering from Type II Diabetes over 2 weeks. The overall state of the skin improved during use of the products. Dryness and itching decreased.
40 30 20 10 0 Initial after 2 weeks (Schaube, 2006 unpublished study) % skin hydration

33,6

38,6

38

39

Product range:
Derma-Soft Wash Emulsion
The unique ingredient composition of sebamed ANTI DRY Derma Soft Wash Emulsion is based on natural skin-related amino acids, glucose and lipids to give dry skin reliable protection against irritation and dryness through lipid erosion. The gentle wash active complex in combination with the re-hydrating capacity of Panthenol is formulated to safeguard and conserve the skins moisture balance, which results in a noticeable improvement of the skin feeling. The pH value of 5.5 protects the skins natural protective acid mantle against dehydration and irritants. Dermatologically tested in dry skin: moisturizes during cleansing. Package size: 200 ml bottle, 1000 ml bottle wih pump
Ingredients: Aqua, Disodium Cocoamphodiacetate, Sodium Lauroyl Glutamate, Sodium Lauroyl Sarcosinate, Cocamidopropyl Betaine, Sodium Citrate, Panthenol, PEG-120 Methyl Glucose Dioleate, Tocopheryl Acetate, Magnesium Sulfate, Glyceryl Laurate, Parfum, Sodium Benzoate.

Day Defense Cream

Protecting, smoothing, and soothing O/W emulsion with 1% Phytosterol concentrate, Avocado oil, and Vitamin E. It spreads easily and penetrates immediately and completely pH 5.5 enhances the skins natural barrier function against dehydration and irritants Package size: 50 ml jar

Ingredients: Aqua, Persea gratissima oil, Glyceryl Stearate SE, Glycerin, Cetearyl Alcohol, Brassica campestris Sterols, Tocopheryl Acetate, Cetearyl Glucoside, Sodium Citrate, Parfum, Phenoxyethanol, Sodium Benzoate.

Night Intensive Cream

Dermatological in-use test of sebamed Anti Dry Derma-Soft Wash Emulsion


Test in 31 persons with dry skin over 3 weeks
100 90 80 70 60 Beginn 1 Woche 2 Wochen 3 Wochen Unterarm Change in skin hydration Stirn

Intensive and rich skin care supports the natural regeneration processes in the skin during the night. The high content (3%) of Phytosterol concentrate together with Jojoba oil and Glycerin in this water-in-oil emulsion provide pronounced soothing, smoothing and regenerating effects. pH 5.5 enhances the skins natural barrier function against dehydration and irritants Package size: 50 ml jar

Ingredients: Aqua, Dicaprylyl Carbonate, Glycerin, Brassica campestris Sterols, Octyldodecanol, Simmondsia chinensis oil, Hexyl Laurate, Polyglyceryl-3 Diisostearate, Polyglyceryl-2 Dipolyhydroxystearate, Sodium Lactate, Cera alba, Magnesium Sulfate, Parfum, Methylparaben, Propylparaben, Butylparaben, Sorbic Acid.

Clinical study with sebamed Anti Dry Day Defense Cream and Night Intensive Cream
Test in 30 persons with dry skin over 3 weeks
150 skin lipids (arbitrary sebumeter values) 140 130 (Wolf et al, Lbeck, 2002 unpublished study)

Hydrating Body Lotion

The organic-sourced active ingredient complex of the lotion effectively nourishes the skin; boosting hydration by 26% within a 3-week period. The phytosterol concentrate supplying rich emollience combines with shea butter, vitamin E and a moisturizing starch derivative for intensive skin care to relieve a dry skin condition. The regenerative capacity of the rapeseed phytosterols concentrate effectively alleviates redness, itching and stinging. The pH value of 5.5 supports the regeneration of the acid mantle. The lotion is rapidly absorbed without leaving residue. Package size: 200 ml bottle

Ingredients: Aqua, Dicaprylyl Ether, Glycerin, C14-22 Alcohol, Butyrospermum parkii butter, Sodium Lactate, Brassica campestris Sterols, Tocopheryl Acetate, C12-20 Alkyl Glucoside, Potato Starch Modified, Xanthan Gum, Parfum, Phenoxyethanol.

120 Beginn 3 Wochen (Schrer, 2002, unpublished study)

Hydrating Shower Balsam

Dermatological in-use test of sebamed Anti Dry Dermasoft Wash Emulsion and Hydrating Body Lotion
Test in 30 cancer patients undergoing chemotherapy. An improvement of the state of the skin, hydration, lipids, and barrier function as well as a decrease in skin symptoms were observed.
2,5

Mild cleansing with rich emollience and moisturizing skin care complex with phytosterols, algae extract, proteins and amino acids. The shower balsam provides protection against dryness and irritation for dry and sensitive skin. The high skin care efficacy reduces the water and lipid loss during showering provides an excellent basis for the subsequent application of creams or lotions. Dermatologically tested. Package size: 200 ml bottle

Skin symptoms severity


2 1,5 1 0,5 0
dryness roughness flaking tension itching stinging erythema erosions

Ingredients: Arachis hypogaea oil, Aqua, MIPA-Laureth Sulfate, Laureth-4, Cocamide DEA, Poloxamer 101, Prunus dulcis oil, Parfum, Brassica campestris Sterols, Algae extract, Palmitoyl Hydrolyzed Wheat Amino Acids, Hydrolyzed Wheat Protein, Glycerin, Lauryldimonium Hydroxy-propyl Hydrolyzed Wheat Protein, Magnesium Sulfate, Sorbitan Oleate, Caprylyl/ Capryl Glucoside, Polyisobutene, Hydroxypropyl Oxidized Starch PGTrimonium Chloride, Sodium Citrate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Ethoxydiglycol, Propylene Glycol, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate.

baseline 1 week 2 weeks final

Revitalizing Shampoo

komedons papules

The extra mild wash active compound gently cleanses the hair without irritating the scalp. The active wheat germ protein and amino acid complex combined with soy portein and guar see somoothes and regenerateds the structure of the hair and relieves the dryness of the scalp. The pH value of 5.5 protects during cleansing to support a rebalancing of the scalp and hair structure. Improvement with 3 weeks: Reduced dryness of the hair by 47%; the scalp 49% Furthermore a 37% reduction of itchiness was achieved Package size: 200 ml bottle

Ingredients: Aqua, Disodium Laureth Sulfosuccinate, Sodium C14-16 Olefin Sulfonate, Sodium Laureth Sulfate, Laureth-2, Coco-Glucoside, Glyceryl Oleate, Sodium PCA, Hydrolyzed Soy Protein, Hydroxypropyl Guar Hydroxypropyltrimonium Chloride, Lauryldimonium Hydroxypropyl Hydrolyzed Wheat Protein, Palmitoyl Hydrolyzed Wheat Amino Acids, Hydrolyzed Wheat Protein, Glycerin, Sodium Lactate, Parfum, Ethoxydiglycol, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate.

(Fluhr et al., in press)

40

41

sebamed Anti-Ageing
Prevention, Protection, Regeneration
The sebamed ANTI-AGEING skin care management system has been created to support the natural metabolic processes and receptivity of the skin to prolong its youthful vitality.

Q10 Lifting Eye Cream

sebamed ANTI-AGEING Q10 Lifting Eye Cream has been formulated to reduce fine lines and wrinkles in the sensitive eye area. Properties and special feature: Less wrinkles in 28 days eye area. The co-enzyme Q10, an important catalyst, which is natural to the body, activates the metabolism of energy on a cellular level. Its production in the skin decreases noticeably from the age of 30. An active ingredient complex based on phytopeptides combined with mucopolysaccharides provides intensive moisture. The valuable, natural lipid resources of shea butter, avocado and almond oils smooth the skin. Package size: 15 ml tube

Ingredients: Aqua, Glycerin, Prunus dulcis oil, Persea gratissima oil, Polyglyceryl-2 Dipolyhydroxystearate, Butyrospermum parkii butter, C12-15 Alkyl Benzoate, Cetearyl Glucoside, Cetearyl Alcohol, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Ubiquinone, Sodium Hyaluronate, Bisabolol, Sodium Lactate, Coco Glucoside, Potassium Cetyl Phosphate, Sodium Citrate, Sodium Carbomer, Butylene Glycol, Parfum, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate.

28 day in-use test


The skin surface profile exhibited significantly increased smoothness in FOITS measurements. 30 test candidates used the eye cream daily for a 28 day period after cleansing.
LIFTING EYE CREAM OPHTALMOLOGIC TEST: 33 women of which16 were contact lens wearers In-use test: twice daily for a period of 4 weeks Results: Conjunctiva tolerance and local skin tolerance was assessed by the ophtalmologist, as well as the probates as good. The anti-wrinkle effect was evaluated as good to very good.

Product range:
Q10 Protection Cream
The visible reduction of fine lines and wrinkles within 28 days and excellent skin tolerance demonstrate the efficacy of this anti-ageing cream without vitamin A derivatives, which can irritate sensitive skin. Co-enzyme Q 10 as important catalyst to activate the metabolism of oxygen in the cells. The free-radical scavenger vitamin E, moisture binding phytosterols and regenerating panthenol combine in this light, yet rich oil-in-water to compensate for existing age-induces changes and to prevent further damage to the skin structure and functions. The pH value of 5.5 supports the barrier function against dehydration and penetration by irritants and allergens. Rapidly absorbed without oily residue to provide 24 hour protection. Package size: 50 ml jar
Ingredients: Aqua, C12-15 Alkyl Benzoate, Glyceryl Stearate SE, Prunus dulcis oil, Cetearyl Alcohol, Sorbitol, Butyrospermum parkii butter, Brassica campestris Sterols, Diisopropyl Adipate, Squalane, Tocopheryl Acetate, Behenyl Alcohol, Panthenol, Ubiquinone, Cetearyl Glucoside, Xanthan Gum, Sodium Citrate, Parfum, Benzyl Alcohol, Phenoxyethanol.

Before use

After use

A reduction according FOITS measurements of wrinkles in the depth of 0 m.

(Institute Schrader, 2003 unpublished data)

(Test institute: proDerma, Hamburg 2005)


Ingredients: Aqua, Hydrogenated Polydecene, Glycerin, Dicaprylyl Carbonate, Butyrospermum parkii extract, Argania Spinosa Kernel Oil, Spent Grain Wax, Ubiquinone, Glyceryl Stearate Citrate, Lauryl Glucoside, Polyglyceryl-2 Dipolyhydroxystearate, Sodium Citrate, Sodium Polyacrylate, Parfum, Benzyl Alcohol, Phenoxyethanol.

Q10 Firming Body Lotion

In-use test of sebamed Anti-Ageing Q10 Protection Cream on 20 women


Evaluation of efficacy and tolerance
Average ratings by users
16

58% validated improvement in firmness within a 3 week period in 93% of the test candidates. Formulated with coenzyme Q 10, which activates the metabolic energy on a cellular level and the innovative botanical ingredient complex Derma Active of argan oil, barley extract and shea butter improve and maintain the elasticity of the skin to counteract firmness. Increased hydration and moisture balance help the skin to regain and maintain its equilibrium to safeguard against premature ageing. The pH value of 5.5 stabilizes the barrier function of the acid mantle to shield against noxious, degenerating influences. Package size: 200 ml bottle

Severity of wrinkles Anti-wrinkle effect Moisturizing effect No. of users Skin tolerance
14 12 10 8 6 4 2 0

2,15 2,15 1,4 2,75 2,2 1,75


good 2 satisfactory 3 below average 4

28 day in-use test


12 8 11
The skin surface profile exhibited significantly increased smoothness in FOITS measurements. 30 test candidates used the lotion daily for a 28 day period after cleansing.

13

Emollience Skin feeling Skin care effect


poor 5 very poor 6

6 1

6 2 0 0
after 1 week

1 0
after 3 weeks

excellent 1

before treatment

none mild

moderate severe
Before use After use (Institute Schrader, 2003 unpublished data)

(Worret, Munich, Germany 2004 unpublished data)

42

43

sebamed F + S Fine + Sensitive New vitality for mature skin


In the fourth decade of life the skin often develops dryness and increased sensitivity. Environmental stress factors like UV radiation, cigarette smoke, air pollution and low air humidity accelerate the inherent aging processes. Skin care with sebamed F+S gives intensive protection and care to dry, sensitive and stressed skin. Its pH value of 5.5 and the selected skin care ingredients support the natural barrier functions against environmental stress factors and decelerate the aging processes. Fine wrinkles are smoothed and skin elasticity is maintained. sebamed F+S has been developed especially to meet the particular needs of mature skin, giving it the right care and protection every day.

Day Cream

Moisturizing oil-in-water emulsion with a 24% lipid content. Protects against dryness with pentylene glycol. Plant lipids: jojoba oil, shea butter, skin-related squalane, phytosterole and ceramide 3 make the skin smooth. Vitamin E protects against free radicals and panthenol supports the regeneration of the skin. Package size: 75 ml jar Dermatological in-use test of sebamed F+S Day Cream
% increase in hydration as compared to initial value
20

Ingredients: Aqua, C12-15 Alkyl Benzoate, Glyceryl Stearate SE, Butyrospermum parkii butter, Pentylene Glycol, Cetearyl Alcohol, Sorbitol, Brassica campestris Sterols, Squalane, Simmondsia chinensis oil, Tocopheryl Acetate, Behenyl Alcohol, Panthenol, Ceramide 3, Cetearyl Glucoside, Sodium Citrate, Xanthan Gum, Parfum.

30 test persons used sebamed F+S Day Cream daily for 2 weeks.

15

10

start

after 2 weeks

(Institute Schrader, Holzminden, Germany 1996, unpublished data)

Night Cream

A water-in-oil emulsion containing 38% lipids for intensive protection and moisturizing action. Jojoba oil and shea butter smooth the skin and prevent it from drying out. Panthenol helps the skin regenerate. Vitamin E protects against premature aging caused by free radicals. Package size: 75 ml jar Dermatological in-use test of sebamed F+S Night Cream % decrease in skin roughness
0 -2 -4 -6 -8

Ingredients: Aqua, Hexyldecanol, Hexyldecyl Laurate, Butyrospermum parkii, Cera alba, Polyglyceryl-2 Dipolyhydroxystearate, Sorbitol, Simmondsia chinensis, Glyceryl Oleate, Tocopheryl Acetate, Sodium Lactate, Panthenol, Magnesium Sulfate, Parfum, Phenoxyethanol, Benzyl Alcohol.

Product range:
Dry Skin Wash
This mild emulsion gently cleanses the skin without removing protecting lipids and moisture or causing irritation. Dermatologically proven to improve the moisture of dry skin areas. Package size: 200 ml, 400 ml bottle with pump
Ingredients: Aqua, Disodium Laureth Sulfosuccinate, Sodium Laureth-6 Carboxylate, PEG-120 Methyl Glucose Dioleate, Decyl Glucoside, Hydrolyzed Silk, Sodium Lactate, Magnesium Sulfate, Parfum, Phenoxyethanol, Sorbic Acid.

Dermatological test of sebamed F+S Night Cream in 20 test persons applying the cream daily for 2 weeks.

-3,5 -7,8
F+S Night cream Competitor product
Ingredients: Aqua, Propylene Glycol Dicaprylate/Dicaprate, Prunus dulcis, Glycerin, Butyrospermum parkii, Polyglyceryl-3 Methylglucose Distearate, Squalane, Lecithin, Ascorbyl Palmitate, Allantoin, Caprylic/Capric Triglyceride, Sodium Citrate, Sodium Carbomer, Parfum, Phenoxyethanol, Benzyl Alcohol.

sebamed F+S Dry Skin Wash: ameliorates skin hydration with mild cleansing agents and the pH 5.5
30 test persons with dry skin washed their face and body twice daily with sebamed F+S Dry Skin Wash for three weeks.
90 skin hydration (rel. units)

(Institute Schrader, Holzminden, Germany 1996, unpublished data)

cheek
85

Lotion

86,2 84,4 78,4 76,6

86,9

80

forearm 74,3
30 test persons used sebamed F+S lotion twice daily for 3 weeks on one forearm, while the other remained untreated.

75

An oil-in-water emulsion containing 21% lipids increases skin smoothness and elasticity. Almond oil, shea butter, skin-related lecithin and squalane make the skin supple and protect it against drying. Absorbs easily and does not leave a greasy film. Package size: 200 ml bottle Dermatological in-use test of sebamed F+S Lotion
14 10 6 2 -2
% change in skin hydration compared with initial value

70

65

68 64

with sebamed F+S lotion without lotion


start after 1 week after 2 week after 3 week

60 start 1 week 2 weeks weeks of use 3 weeks

-6
(Weltzel, Wolf, Lbeck, Germany 1997, unpublished data)

(J.Welzel, H. H. Wolff, M.Arens-Corell, T&E Dermatologie 1998)

44

45

Visio
Protection and moisture for the sensitive facial skin
Facial skin is thinner and more permeable than the skin on other parts of the body. Furthermore, the face is much more exposed to noxious environmental factors like UV radiation, pollutants, and low air humidity. Additionally, skin alterations in the face are clearly visible, and therefore of higher concern to an affected person. Thus, it requires special care, protection and skin tolerance.

Gentle Facial Toner

Tones and revitalizes the skin after cleansing, refreshing the complexion. To be applied with the help of tissue or cotton pad. Use mornings and evenings. Especially developed without alcohol for sensitive skins of all types. The moisturizing properties of witch hazel, cucumber extract and hydrolyzed silk are absorbed easily by the skin. Allantoin makes the skin smooth and supple. Package size: 200 ml bottle Increase in Skin Hydration by sebamed VISIO Gentle Toner

Ingredients: Aqua, Pentylene Glycol, Sodium Lactate, Polysorbate 20, Saccharide Isomerate, Glycerin, Propylene Glycol, Hydrolyzed Silk, Cucumis sativus fruit extract, Hamamelis virginiana bark/ leaf/ twig extract, Allantoin, Menthol, Farnesol, Caramel, Parfum, Potassium Sorbate, Sodium Benzoate, CI 42090.

sebamed VISIO Skin Toner increased skin hydration in 20 test persons markedly.

Change in skin hydration (rel. Units)


40 30 20 10 0 0 5 10 20 30 40 60 90 120 180 240 minutes

(Institute For Applied Skin Physiology, Holzminden, Germany 1995, unpublished data)

Day Cream

Product range:
Gentle Cleansing Milk
Moisturizing cleansing milk to support the skins own acid mantle. To be used on wet or dry skin and removed with the help of tissue or cotton pad, or rinsed off with water. Visio Gentle Cleansing Milk combines the benefits of a cleansing emulsion with a moisturizing lotion. Mild cleansing agents remove dirt and make-up gently and thoroughly. Its plant-based moisturizing complex Biophytex contains marigold extract, yeast protein and active moisture retaining ingredients, which enrich the moisture balance of the skin during cleansing. The result is an immediate 41% increase in moisture content. Package size: 200 ml bottle
Ingredients: Aqua, Glycerin, Caprylic/Capric Triglyceride, Paraffinum liquidum, Cetearyl Alcohol, Propylene Glycol, Ruscus aculeatus root extract, Decyl Oleate, Centella asiatica extract, Panthenol, Calendula officinalis flower extract, Hydrolyzed Yeast Protein, Aesculus hippocastanum extract, Ammonium glycyrrhizate, Glyceryl Stearate, Sodium Citrate, Sodium Cetearyl Sulfate, Laureth-23, PEG-40 Stearate, Sodium Carbomer, Dimethicone, Parfum, Chlorphenesin, Methylparaben, Potassium Sorbate, Phenoxyethanol, Sodium Benzoate.

Especially formulated for the protective care of dry and sensitive skin. Daily use supports the skin to activate its natural moisturizing system. The sophisticated scientific formulation with allantoin, panthenol and the naturally moisturizing hyluronic acid activates the skins hydrolipid system and promotes cell regeneration. Combined with the vitasqualane complex, the skin is assured optimal hydration, making it soft and supple. Package size: 50 ml jar

Ingredients: Aqua, Propylene Glycol Dicaprylate/Dicaprate, Ethylhexyl Methoxycinnamate, Cetearyl Alcohol, PPG-2 Myristyl Ether Propionate, Glycerin, Cetyl Palmitate, C12-15 Alkyl Benzoate, PEG-20 Methyl Glucose Sesquistearate, Tocopheryl Acetate, Panthenol, Squalane, Sodium Hyaluronate, Allantoin, Sodium Citrate, Sodium Cetearyl Sulfate, Methyl Glucose Sesquistearate, Sodium Carbomer, Parfum, Phenoxyethanol, Sorbic Acid.

Hydro Gel

Increase in Skin Hydration by sebamed VISIO Cleansing Milk sebamed VISIO Cleansing Milk increased skin hydration in 20 test persons like a moisturizing lotion. Even after 4 hours, a 20% increase in hydration was still detectable.
Change in skin hydration (rel. Units)
30

The humectant potential of the hydro gel is beneficial for all skin types. Visio Hydro Gel distinguishes itself through its high dermatological tolerance equally on very dry atopic skin and even oily skin requiring moisture to regain balance. Visio Active Hydro Gel with its micro thalaspheres of marine mucopolysaccharides, botanical ceramide and borage oil increase the humectant capacity of the skin. These active ingredient depots are released slowly, and penetrate easily through their skin-related molecular structure. Package size: 50 ml jar In-use test of sebamed Visio Hydrogel

Ingredients: Aqua, Aloe barbadensis leaf gel, Propylene Glycol, Glycerin, Sorbitol, Panthenol, Allantoin, Glycine soja oil, Borago officinalis seed oil, Atelocollagen, Lecithin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Sodium Carbomer, Sodium Citrate, Butylene Glycol, Ethylparaben, Methylparaben, Phenoxyethanol, Propylparaben, Sorbic Acid, CI 77289.

VISIO Cleansing Milk


25 20 15 10 5 0 0 5 10 20 30 40 60 90 120 180 240 minutes

moisturizing lotion

sebamed VISIO Hydro Gel decreased skin roughness and increased skin hydration during 2 weeks with twice daily application in 20 text persons after repeated (twice daily) skin dehydration by washing with Sodium Lauryl Sulfate.

5 4 3 2 1 0
-1

% change in skin roughness

10 8

% change in skin hydration

4,21 untreated

6 4 2 0

8,8 VISIO Hydro Gel


untreated -8,31

-2 -3 -4 -5

VISIO Hydro Gel -4,42

-2 -4 -6 -8 -10

(Institute Schrader, Holzminden, Germany 1995, unpublished data)

(Institute Schrader, Holzminden, Germany 1995, unpublished data)

46

47

Literature
Bayerl C, Walker T, Arens-Corell M: Dermatologically controlled in-use test of sebamed soap-free washing bar in a daily care unit. Poster presented at the World Congress of Dermatology 2007 Behne MJ, Meyer JW, Hanson KM et al : NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem 277: 47399 47406, 2002 Berardesca E, Mosca M, Rona C, in preparation. Combining cleansing and care in one product - Dermatological evaluation of a shower cream for dry skin. Int J Cosmet Sci Bibel DJ, Miller SJ, Brown BE, Pandey BB, Elias PM, Shinefield HR et al. Antimicrobial activity of stratum corneum lipids from normal and essential fatty acid-deficiency mice. J Invest Dermatol 92: 632-638, 1989 Bhm G, Nutzmann J, Jansen M, Heussen N, Gehring W, Schumpelick V: Neue Hautemulsion zur Behandlung der postoperativen Hautquellung der Chirurgenhand eine klinisch prospektive Studie. Kosmetische Medizin 271-76, 2005 Bornkessel A, Flach M, Arens-Corell M; Elsner P, Fluhr JW: Functional assessment of a washing emulsion for sensitive skin: mild impairment of stratum corneum hydration, Ph, barrier function, lipid content, integrity and cohesion in a controlled washing test. Skin Res Technol 11: 53-60, 2005 Braun F, Boeck A, Hackl P: Observations on Usage and Efficacy of a Shampoo/Bath and Creamlotion in Newborns, Presentation of the Congress of the European Socienty of Pediatric Dermatology, Budapest May 5-7, 2005 Budde F, Rping KW, Stary A, Tronnier Haut, 89. Wirksamkeitsprfung von Hautpflegemitteln. hautnah Pdiatrie IV Dott W, 1992. Principles of bacterial ecology. In: Braun-Falco O, Korting HC. Skin cleansing with synthetic detergents, Springer Heidelberg Elias PM: Stratum corneum defensive functions: An integrated view. J Invest Dermatol. 125: 183-200, 2005 Fluhr Fluhr JW, Miteva M, Primavera G, Ziemer M, Elner P, Berardesca E: Functional assessment of a skin care system in patients on chemotherapy. Skin Pharmacol Physiol, in press Gehring W, 1992. Irritantienmodelle an Haut und Schleimhaut. BMV Berlin: 82 - 83 Gehring W, Gloor M, 1990. Effects of pH changes in a specific detergent multicomponent emulsion on the water content of stratum corneum. J. Soc Cosmet Chem 42: 327 - 333 Gehring W Gloor M, 1999. Neue Aspekte zur Modulation einer reduzierten epidermalen Barrierfunktion. Z f Haut- und Geschlechtskrankheiten 74: 530 Gehring W, Kemter K, Nissen H-P, Gottfreund J, Gloor M, 1995. Zeitschrift f Haut- und Geschlechtskrankheiten 70 (9): 643 - 648 Gehring W : Das Stratum corneum in vitro Ein Modell zur Entwicklung von Hautschutzprparaten mit entquellenden Eigenschaften auf die Hornschicht. Dermtolog Beruf Umwelt 51: 139-145, 2004 Greif C, Wigger-Alberti W, Arens-Corell M, Elsner P, 1998. Beurteilung einer Krperlotion fr trockene und empfindliche Haut. Kosmetische Medizin 19: 284 - 288 Jacobi O, 1954. Der Suremantel der Haut in der Kosmetik. Fette Seifen Anstrichmittel 56: 928 - 933 Keil D, Jung FG, Bayerl C, in preparation. Effects of a synthetic detergent skin cleanser for mild acne on skin barrier function Keil D, Jung EG, Bayerl C : Zur Problematik der Vertrglichkeitstestung bei Deodorantien. Akteulle Dermatologie 28: 83-89, 2002 Keil, D, Jung EG, Bayerl C: Effects of a mild detergent syndet cleanser for mild acne on skin barrier function. Ann Derm Venereol, 129: S 377, 2002 Kober M, 1992. Determination of skin surface pH in healthy subjects. Methods and results of clinical studies. In: Braun-Falco O, Korting HC. Skin cleansing with synthetic detergents, Springer Heidelberg Korting HC, Hbner K, Greiner K, Hamm G, Braun-Falco O, 1990. Differences in the skin surface pH and bacterial microflora due to longterm application of synthetic detergents. Acta Derm Venereol (Stockh) 70: 429 - 457 Korting HC, 1992. Marchioninis acid mantle concept and the effect on the skin resident flora of washing with skin cleansing agents of different pH. In: Braun-Falco O, Korting HC. Skin cleansing with synthetic detergents, Springer Heidelberg Korting HC, Megele M, Mehringer L, Vieluf D, Zienicke Haut, Hamm O, Braun-Falco O, 1991. Influence of skin cleansing preparation acidity on skin surface properties. Int J Cosmetic Sci 13: 91-102 Korting HC, Kober M, Mueller M, Braun-Falco O,1987. Influence of repeated washings with soap and synthetic detergents on the pH and resident flora on the skin of forehead and forearm. Acta Derm Venereol (Stockh) 67: 41-47 Korting HC, Ponce-Pschl E, Klvekorn K, Schmtzer G, Arens-Corell M, Braun-Falco O, 1995. The influence of the regular use of a soap or an acidic syndet bar on pre-acne. Infection 23: 89-93 Korting HC, Schmid-Wedtner MH: pH and the skin. In press. Krien P, Kernicki M: Evidence for the existence of a self-regulated enzymatic process within human stratum corenum an unex pected role for urocanic acid. J. Invest. Dermatol., 115: 414-420, 2000 Lee SH, Jeong SK, Ahn SK: An update of the defensive barrier function of skin. Yonsei Medi J 47 (3): 293-306, 2006 Lucacz A, 1992. In-vitro control of the growth of important bacteria of the resident skin flora by changes in pH. In: Braun-Falco O, Korting HC. Skin cleansing with synthetic detergents, Springer Heidelberg Marchionini A, 1929. Untersuchungen ber die Wasserstoffionenkonzentration der Haut. Arch Dermatol Syph 158: 290 - 333 Mauro T, Halloran WM, Grayson M, Gao WN, Man M-Q, Kriehuber E, Behne M, Feingold KR, Elias PM, 1998. Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing. Arch Dermatol Res 290: 215-222 McNally NJ, Williams HC, Phillips DR, Smallman-Raynor M, Lewis S, Venn A, Britton J 1998. Atopic eczema and domestic water hardness. Lancet 352 (9127): 527 - 531 Molnr K, Szalai S: Moistuirizing effect of Baby sebamed Bubble Bath on ibnfants and small children Results of an in-use test. Presentation at the 25 International Congress of Pediatrics, Athens, August 25 30, 2007 Osborne DW, Friberg SEBAMED, 1987. Role of stratum corneum lipids as moisture retaining agent J.Dispersion Science and Technology 8 (2): 173-179 Schmid-Wendtner MH, Korting HC : The pH of the ksin surface and its impact on the barrier function. Skin Pharmacol Physiol. 19: 296-302, 2006 Sera Baldrich E, Trib MJ, Barranco C, Lloreta C, Camps A, Mascar-Galy JM, Camaras JM, Pujol RM, 2001, J Europ Acad Dermatol Venerol 15 (Suppl 2): 188 Soehnchen R, 1992. Structure of human skin, and influence of environment factors, such as pH on the growth of keratinocytes Results of cell culture experiments. In: Braun-Falco O, Korting HC. Skin cleansing with synthetic detergents, Springer Heidelberg Welzel, J, Wolf HH, Arens-Corell M, 1998. Zur Vertrglichkeit neuentwickelter Hautreinigungsprodukte. T&E Dermatologie 28: 63 - 66 Worret WI, Gehring W: Kosmetische Dermatologie. Springer Verlag Heidelberg2004; p.45. Yosipovitch G, Maibach HI, 1996. Skin surface pH: A protective acid mantle. Cosmetics and Toiletries 111: 101 Zhai H, Behnam S, Villarama CD, Arens-Corell M, Choi MJ, Maibach HI: Evaluation of the antioxidant capacity and preventive effects of a topical emulsion and its vehicle control on the skin response to UV exposure. Skin Pharmacol Physiol. 18 : 288 293, 2005 Zienicke Haut, 1992. Skin hydration (transepidermal water loss)- Measuring methods and dependence on washing procedure. In: Braun-Falco O, Korting HC. Skin cleansing with synthetic detergents, Springer Heidelberg