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Science for healthy skin.
Table of contents
Preface by Dr. Heinz Maurer Preface of the Scientific Advisory Board The acid mantle of the skin
The pH value of the skin is slightly acidic The acid mantle stabilizes the ecological balance of the skin’s micro-flora The proliferation and differentiation of the skin cells is pH-dependent The acid mantle stabilizes the barrier structures of the Stratum corneum lipids The acid mantle supports the synthesis of barrier forming lipids within the Stratum corneum
4 5 6 7 8 9 10 11 12 13-14 15 16-18 18-19 20-23 24-25 26-27 28-32 33-35 36 37-39 40-41 42-43 44-45 46-47
The influence of skin care on the acid mantle
Washing with soap impairs the acid mantle Even pH neutral skin cleansing influences the skin surface pH Influence of the pH value of cleansing preparations on the skin’s micro-flora Influence of the pH value on the dehydration of the skin Influence of the application of skin care products on the pH value of the skin
sebamed soap-free skin cleansers sebamed Feminine Intimate Wash sebamed protective care products sebamed hair care system sebamed Deodorants Baby sebamed Clear Face sebamed sun care sebamed Anti-Dry sebamed Anti-Ageing sebamed F+S Fine+Sensitive sebamed Visio Literature
The first successes with soap-free tensidic products encouraged me to carry on with the development of a preparation for the cleansing of problem skin. in which sebamed is still the market leader after more than 30 years. and to contribute to optimizing the efficacy and safety of skin care products. and Pharmacy are necessary to elucidate the interactions between the organ skin. Darchinger Preface of the Scientific Advisory Board In 2006. adequate skin care can provide substantial support of the therapy and healing process. research activities. Switzerland and Norway) was 147 Euro. In skin diseases. There was an increasing focus on skin care as a means of keeping the skin healthy and preventing skin diseases. At this time a soap prohibition existed for patients with skin diseases. which are summarized in this brochure to give you. the Scientific Advisory Board of Sebapharma has provided Sebapharma with its vital connection to the scientific community devoted to dermopharmaceutical research.2 Billion Euro spend on cosmetic products in Western Europe. as well as. The value and rewards of such efforts are demonstrated by the essential benefits. which has been achieved in the evolution of the methods utilized for product testing and evaluation in the course of the last decades. international universities. The presented studies also demonstrate the progress. cleanliness also has an integrative social role in modern society. in contributing to the maintenance of the skin's health. The deterioration of the latter skin condition caused by the regular use of soap. especially in the fields of Dermatology. Therefore it has become a seemingly self-evident necessity in everyday life. The result was the market introduction of sebamed Cleansing Bar forty years ago in 1967. To this end sebamed bestows biannually the Heinz Maurer Award for dermatological research on the skin’s surface and its environment. Besides its hygienic function. which has played a prominent role from the very beginning. photographed by J. an objective impression of the product performance of sebamed medicinal skin care. who suffer from a genetic disposition to dry skin. which impair or even damage the physiological functions of the skin. also finds its expression in the large number of scientific publications. can be avoided by using an acidic syndet. which had rendered the soap prohibition obsolete. My primary motivation for the development of sebamed was my experience in the Dermatological Department of the University of Bonn in the 1950ies. and skin care products. the environment. photographed by J. The establishment of this interdisciplinary co-operation has proven to be of special value. However. Reflecting on this statistical data and the fact that skin care can have positive. which is expressed in the research results presented on the following pages. It’s not insignificant to mention the role that skin care plays.risk analysis of sebamed products. Dermatological research has made significant advances in recent years. This brochure documents the medical/scientific evaluation of the in-use benefit. The company’s principle QUALITY THROUGH RESEARCH. State-of-the-art dermatological research calls for a scientific benefit-risk-analysis similar to that for drugs. Since 1992. the average per capita spending on skin care in Western Europe (EC-countries. which is further provoked by the daily cleansing with soaps or syndets and deteriorated by this irritation of the skin. Additionally. Medicinal skin care requires intensive efforts in dermatological research . Darchinger . It is my aim to continually optimize the efficacy and skin tolerance of sebamed products through the perpetual adaptation of their formulae to reflect state-of-the-art dermatological research acquired through close cooperation with notable. and in the prevention of skin damage and diseases. that have been achieved for such population groups as the 20%. This incremental increase in the understanding of the physiology and pathology of the skin has lead to establishing fundamental requirements for medicinal skin care and the development of objective methods to evaluate the efficacy and safety of products. which has been the foundation of the brand sebamed since the very beginning. this fact also creates considerable dermatological problems for a large group of people.H. or the 80% of adolescents with predominantly moderate forms of acne. This hardly tolerable stress drove my search for a solution. a growing number of people were encountering skin problems as an undesirable side effect of the regular use of increasing amounts of products. Chemistry.H. amounting to a total 4. Heinz Maurer Skin care is a basic human need: it starts with cleanliness.4 5 Preface by Dr. the reader. This created a new category: Medicinal Skin Care. an altered view on skin care was slowly developing within the whole population. negative effects on the skin. This fact alone indicates the significance of skin care in modern society. dermatologists and pharmacists during the process of product development and elaboration. While initially only persons with skin problems benefited from this innovation.
5 6. Micrococcae. as shown by the advanced technology of Fluorescence Lifetime Imaging (FLIM. Within the Stratum corneum and the hydrolipid film the average pH value lies between 4. and corneocytes. predominately in the extracellular domains with a gradient towards the viable epidermis – (Fotos were kindly provided by M. 2005).5 6.6 1. Growth optima of Staphylococcus epidermidis and Propionibacterium acnes Staphylococcus epidermidis Specific growth rate (h-1) 1.2 0.0 7.0 7. in the epidermis up to the Stratum granulosum. Toes 5 000 000/cm2 (coryneform.0 6. Changes in the skin’s surface pH lead to quantitative and qualitative alterations in the skin’s micro-flora (Braun-Falco.0 5. 20001). propionibacteria) Forehead/scalp 100 000/cm2 (staphylococci.0. micrococci) Perineum 5 000 000/cm2 (Gram negative bacteria. New investigations also demonstrated the presence of a Na+/H+-anti-porter system in the membranes of keratinocytes and in the Stratum corneum which is expressed in the dependence of the cell differentiation and produces an acidic milieu by the exchange of H+ from the cells into the intercellular space (Hachem et al. As early as 1938. In the deeper layers with living cells.6 0. micrococci. Additionally. the pH reaches the neutral range.5 present in the Stratum corneum and the hydrolipid film. sebum and metabolic products of the skin surface bacteria. 1992) Between the various organisms there exists in part antagonistic interactions like competition for room and nutrition.1 Propionibacterium acnes Specific growth rate (h-1) 0.8 0. The acidic pH is not homogenously present throughout the whole Stratum corneum but localized in clearly defined domains within and in between individual corneocytes with a non-linear gradient toward the Stratum granulosum. Marchionini found a relation between the skin’s surface pH and its colonization with microorganisms.4 0.2 5.2 1. This observation made by Marchionini (1929) was confirmed by later investigations (Korting 1992).5 pH (Lucacz. . due to the redundant sources of hydrogen ions in the Stratum corneum described above.5 7. ammensalism by excretion of substances inhibiting the growth of other species or impairing them directly (Dott 1992). Hamburg. The growth optima.0 pH 5. vary markedly between the different species (Lucacz 1990). 19892) The skin shows considerable resistance against pH changes. Behne et al.4 1.6 7 The acid mantle of the skin The pH value of the skin is slightly acidic The skin surface has a slightly acidic pH. An impairment of the alkali neutralization capacity and even elevated Stratum corneum pH values are present in various skin diseases and physiologically in newborns whose skin surface pH drops from near neutral to slightly acidic within a few days to weeks.5 and 6. The commensalic resident flora of the skin: Staphylococci. sweat. however. coryneforms) Ecological areas of the microbial skin flora (Dott. micrococci) Axilla 5 000 000/cm2 (coryneform. 1992) This acid mantle was formerly thought to be created solely by sweat. Free fatty acids produced by hydrolysis of sebum lipids by lipases from species of the skin resident flora are also acidifiers of the Stratum corneum (Bibel et al.5 7.0 6.J. propionibacteria) Hand 1 000/cm2 (staphylococci.5 8. Korting 1995). Department of Dermatology and Venerology University Hospital Hamburg-Eppendorf. Germany) The acid mantle stabilizes the ecological balance of the skin‘s micro-flora The acid mantle of the skin fulfills a variety of protective functions.0 0. propioibacteria) Nasopharynx 10 000 000/ml (streptococci) Non-exposed skin 500/cm2 (staphylococci. It is more or less well adapted to the slightly acidic pH. enzymatic processes like the liberation of free fatty acids from phospholipids by acid phospholipase A2 contribute to the establishment of the acidic pH (Fluhr et al. Propionibacteria and coryneform bacteria (Dott 1992) lives predominantly from sebum.Behne. 2004) As a third mechanism of acidification the formation of urocanic acid derived from histidine as a breakdown product of filaggrin has been identified (Krien and Kermici. together with the buffer capacity of fatty acids produced and the long-known lactic acid/lactate system. 2002) The skin’s acid mantle – average pH of 5.
0 globular micellae form. At pH values over 6.4 as compared with a buffer with pH 5. according to the findings of Osborne and Friberg (1987).0. Increase in Stratum corneum pH inhibits some of the enzymes involved while acitvating others. (1998) demonstrated a higher activity at pH 5.0 0 2 4 6 8 10 12 14 d (Soehnchen. Besides the bilammellary lipid sheets. The specific inhibition of this enzyme leads to both an increase in the skin pH and a disturbance of the barrier function as well as decreased cohesion of the corneocytes resulting in a decreased integrity of the Stratum corneum (Fluhr et al. Outside the pH range mentioned above. 2001) Recent studies have revealed a further role of the acid mantle in maintaining Stratum corneum cohesion and integrity and. (1999) may explain this observation.0 Epidermis (pH 7. keratinocytes require a slightly acidic milieu for optimal proliferation – at pH 5.5 in skin barrier maintenance Barrier lipids pH > 6.5 as compared with pH 7. Jeung. The culture medium of the keratinocytes shows an acidification with time (Soehnchen 1990). 1992) The acid mantle stabilizes the barrier structures of the Stratum corneum lipids The bilamellary structure of the intercellular lipids in the Stratum corneum is crucial for the skin's barrier function. Schmid-Wendtner 2007) 15 Keratinocyte growth at different pH levels 10 Constant pH 6.8 9 The proliferation and differentiation of the skin cells is pHdependent In cell culture.0 pH 6. Cells x106 The acid mantle supports the synthesis of barrier forming lipids within the Stratum corneum Extracellular lipids undergo various enzymatic processes after their secretion from the Odland bodies at the transition between the Stratum granulosum and the Stratum corneum.5. The formation of free fatty acids by secretory phospholipase A2 as constituents of the barrier lipids from phospholipids secreted from the lamellar bodies is also a mechanism for the maintenance of the homeostasis of the acid pH value within the Stratum corneum. leading to irregular desquamation and decreased Stratum corneum integrity and cohesion (Hachem et al.5 pH < 4. Schmid-Wendtner.. on the other hand. The role of the pH for the skin barrier function has recently been repeatedly reviewed (Elias 2005. ß-glucocerebrosidase. For one of the enzymes involved. At lower pH values the lipids are freely dissolved without any ordered structure. Mauro et al. ceramides from sphingolipids. the desquamation process through attenuation of the activity of serin proteases and probably also other enzymes involved in the break-down of corneodesmosomes.5 and 6. was markedly delayed under exposure of the skin to a buffer with pH 7. resulting in an increased water loss from the skin and an enhanced penetration of exogenous substances to which the skin is exposed. the barrier function of the intercellular lipids of the Stratum corneum is lost. Korting 2006. this feature may play a major role for the skin’s barrier function. The exchange of extracellular sodium cations against intracellular hydrogen ions found by Behne et al. Korting.5) Free fatty acids Ceramides Cholesterol pH 5..0. which produce hydrophobic lipids from more hydrophilic precursors. the cell growth is markedly inhibited as compared with pH 6. Recovery of the barrier function after experimental impairment by lipid extraction from the skin with aceton in vivo as measured by an initial rise in transepidermal water loss (TEWL) and subsequent gradual decrease back to baseline values. 2005).0 5 pH 7. Ahn.0 pH 5.5 Proteins of the cornified envelope (CE) Involucrin Loricrin Elafin Desmoplakin Cytostatins pancornulins/cornifins Corneocytes/cornified envelope Maintance of Stratum corneum integrity and cohesion Regulation of desquamation Influence of pH on the conformation Stratum corneum lipids (Osborne & Friberg. Double lamellae form only at a pH range between 4. Role of pH 5. 2006.4): barrier lipid percursors Phospholipids Sphingolipids Glucosylceramides Cholesterolsulfate Stratum corneum (pH 5. respectively. Lee.5) lipid processing enzymes activated by acidic pH Acid Phospholipase Acid Shingomyelinase ß-Gluccosylcerebrosidase independent of pH Sulfatase Enzymes involved in breakdown of coreneodesmosomes Serin proteases (most active at pH 7) Cathepsin D Aspartate proteases (active at acidic pH) Cysteine proteases (active at acidic pH) barrier lipids (bilamellary structure stabilized by pH.0 and 22.214.171.124. 1987) . for instance.
5 2 1. the pH is adjusted to a neutral or to the physiological. followed by pH 5.5 and 8. Probably this makes skin cleansing with syndets more skin friendly than soap in areas with harsh water (McNally et al.5 during the first 4 weeks. Syndets. 1992) .0 hing with two syndet preparations of iden tical composition.5 (sebamed Liquid Face & Body Wash) subsequently in a crossover design pH value of the skin surface 6 5.e. Change of skin pH after washing with alkaline soap and an acidic syndet Long-term course of the mean forearm pH following the use of a soap and of a soap-free cleansing product with pH 5.5 during the first 4 weeks. product. The pH of syndet cleansers can be adjusted freely within a broad range.5. 1992) Soap Even pH neutral skin cleansing influences the skin surface pH Soap-free cleansing preparations contain synthetic detergents – in short syndets – as cleansing agents.5 differing only in their pH (5. independent of water harshness..5 pH 8.5 -1 -5 0 30 60 90 120 150 180 minutes after washing (Kober. 5.5 (Korting et al. unlike soaps. Repetitive washing with soap leads to a permanent though slight increase of the skin surface pH (Korting 1990). pH 5. enables them to dissolve fatty soiling and thus cleanse the skin thoroughly.5 0 Soap-free. This makes it possible to adjust the skin tolerance and cleansing efficacy to the individual requirements. same composition of sebamed Liquid Face & Body Wash. Usually. i. magnesium and calcium rich water.5. which they share with soaps. Thus they do not loose their foaming and cleansing efficacy and can be used economically. slightly acidic value of 5.5. The importance of the pH in skin cleansing change of pH value 2. respectively) 5. Acidic pH values cannot be established without loosing the surfactant activity. the acid mantle is disturbed in a similar way as by an alkaline soap (Zienicke 1992). When an alkaline syndet (pH 8. Even in healthy skin the alkali neutralization capacity is exhausted by a single wash process resulting in a prolonged increase in the skin surface pH (Kober 1990). always form lyes in aqueous solution with pH values between 8 and 12. They have some advantages as compared with soap: The chemical variability of the syndets is high as compared with soap.0 syndet – soap 5 4. 1997) (Zienicke. an acidic syndet preparation Change of skin pH surface pH after wasswitch in cleansing preparation 6. 1998) Syndets do not form lyes. except for pH) is used for skin cleansing.5 1 0..10 11 The influence of skin care on the acid mantle Washing with soap impairs the acid mantle Soaps: alkali salts of long-chain fatty acids by chemical definition.5 0 1 2 3 4 5 6 7 8 weeks 12 3 10 17 24 31 38 45 52 59 Time days pH 5. This is not the case when the acidic syndet sebamed is used for washing. form no insoluble lime soaps in harsh. Their surfactant activity.5 soap – syndet Change of skin pH after washing with alkaline vs.5 -0. followed by pH 8.
0 or 8. even though it causes a momentary pleasantly smooth skin feeling.5 2 -2 1.12 13 Change of skin surface pH after washing with two syndet preparations of identical composition.5. 5.5.. log (colony forming units) 3. a species with a narrow growth optimum between pH 6.4 5. pH 6.5 soap – syndet syndet – soap 6 pH 5. as shown in a cross-over study (Korting 1992). prewash minutes after washing (Gehring et al.5 during the first 4 weeks. just like pH-related conformation changes of the barrier lipids.5).8 5. composition equal to sebamed Liquid Face & Body Wash. This leads to a swelling. which impairs its barrier function. followed by pH 5.0.2 5 4. Korting et al.2 6 Influence of the pH value on the dehydration of the skin After washing the skin hydration first increases by an up-take of water resulting in skin swelling. The degree of this increase depends on various factors like the duration of the water exposure. which mediates a smooth skin sensation immediately after washing but gives way to an increased dehydration later on.5 (Zienicke 1990.0 pH 7. Hydration and dehydration after treatment with detergent solutions of different pH values – corneometric skin capacitance measurements change in water content of the skin (relative units) 10 switch in cleansing preparation 5. the pH value. This is paralleled by structural damage to the epidermis with loss of nuclei of the keratinocytes at pH values above 9 (Gehring 1992)..0 3 switch in cleansing product 2.0 or 7. followed by pH 7. than at pH 7. The more skin lipids and moisturizing factors are removed together with soiling. except for pH) leads to an increase of the skin surface pH. differing only in their pH (5.5 2 pH 7. The incubation of human skin in vitro with Isopropylpalmitate and Cetiol HE caused a structural damage of the Stratum corneum. Skin swelling is always followed by a loss of hydration of the Stratum corneum below the initial level. and the quality and quantity of the cleansing agents applied. 1992) The crucial factor for the decrease in bacterial count is the pH value. A comparison of cleansing preparations of different pH showed a minimal swelling at a slightly acidic pH. Skin swelling has to be considered as an adverse effect of skin cleansing. In standardized washing procedures. 1991) .5 (Korting et al.0.5 and the original value of sebamed Liquid Face & Body Wash.0 and 6. Evolution of Propionibacterium acnes counts per cm2 on the subjects’ foreheads during repeated applications of alkaline soap and acidic syndet in the frame of a comparative cross-over trial. the temperature.9 pH 7. Gehring and Gloor (1990) found a shorter lasting and less pronounced dehydration by soap-free syndet preparations adjusted to a slightly acidic pH (4.8 1 2 3 10 17 24 31 38 45 52 59 Time days pH 5.6 5.5 and 7. as in further tests the syndet preparation produced an increase in bacterial counts if its pH was adjusted to 7. but decreased when sebamed Liquid Face & Body Wash with pH 5.5 (Korting 1991). respectively) Even a pH-neutral syndet (pH 7. 1991) Influence of the pH value of cleansing preparations on the skin’s micro-flora The bacterial count of Propionibacterium acnes.. the stronger is the dehydration. It falls back to the initial level much more slowly than after washing with the original sebamed Liquid Face & Body Wash with its pH 5.5 was used. The loosening of the Stratum corneum barrier structures by the previous swelling processes further amplifies the dehydration.8 4. increased under repeated washings with soap.0 during the first 4 weeks. 1990).5 -6 1 0 1 2 3 4 5 6 7 8 weeks -10 0 30 60 90 120 150 180 (Korting et al.
Gehring (2000) could show that even 3 hours after the application of an alkaline cream an increased pH value was still measurable on the skin surface. By contrast. its barrier function. (Gehring et al. are left on the skin until the next washing. Skin care preparations. Skin cleansing preparations are removed almost completely from the skin surface by rinsing after a short exposure period. 2004) Dermatological tests provided evidence that additives for re-lipidization in cleansing preparations cannot reduce dehydration or lipid loss. the skin hydration.5 did not chance the skin pH. 7 and 8 to their forearm on 5 consecutive days. Comparison of the hydrating effect of cream formulations differing solely in their pH Change in skin hydration 4 58. standardized washing procedures with cleansing preparations which were diluted to give equal cleansing effects. At pH 5. The change in skin hydration before the first and after the last application was measured. -10 -12 -14 -16 -18 n = 25.5 alkaline soap semisyndet -2 -4 -6 Influence of the application of skin care products on the pH value of the skin While the influence of the pH value of cleansing preparations on the acid mantle. Gehring. 1995) . the increase was significantly higher than at pH 8.5 sebamed F+S Dry Skin Wash semisyndet soap A re-lipidizing agent added to a cleansing formulation does not reduce skin dehydration n=15 15 10 5 0 skin capacitance (relative units) 0 pH 4 -1 pH 5. by contrast.8 59 3 2 15 test persons applied cream formulations of identical composition. F: p < 0.5. 5. leading to less dehydration and lipid loss than soaps. 1 9.05. By contrast. All skin care products which contain water have a definite pH value in their aqueous phase.14 15 Skin dehydration after washing with alkaline soap and the acidic syndet sebamed F+S Dry Skin Wash 0 30 60 90 120 150 0 syndet pH 5. which usually is performed only after several hours.5.. Modern syndet preparations with milder cleansing agents like sebamed Dry Skin Wash can be adjusted to the requirements of dry skin..4 0 syndet with pH 5. many dermatologists still recommend soaps for dry skin. all cleansing preparations adjusted to equal cleansing efficacy (Gehring et al. the effect of the pH value of creams and lotions has scarcely been studied yet. resulted in more pronounced loss of water and squalen from the skin when two frequently used re-lipidizing additives were added than with the original preparation. -5 -10 -15 -20 -25 0 30 60 90 120 150 180 min n=15 basic cleansing formulation (sebamed F+S Dry Skin Wash. Therefore. dilution 1:8) The well-established influence of the pH of skin cleansing preparations on the skin physiology supports the demand formulated by Yosipovitch and Maibach (1996) for slightly acidic skin care preparations with a pH of 5. due to the content of cleansing agents like Sodium Lauryl Sulfate.3) caused an increase in skin surface pH which could be observed over 75 minutes. whereas the same formulation adjusted to pH 5. 1995) (Worret. dilution 1:8) basic formulation with re-lipidizing agent (5% polyethylene 7-glyeryl cocoate. but with pH 4. and the resident skin flora is well known. which cause damaging lipid removal and disturb the barrier.5 pH 7 pH 8 untreated (Gehring et al. In a study by Jacobi (1954) an alkaline cream (pH 8. 1995) Comparison of the lipid removal by washing with different products % loss of squalen by standardized washing 60 50 40 30 20 10 Older syndet preparations often had dehydrating or even irritative effects. such syndets were predominantly used for skin diseases associated with seborrhoea.5..
Sodium Chloride. Disodium Laureth Sulfosuccinate. Sodium Lauroyl Sarcosinate. Palmitoyl Hydrolyzed Wheat Amino Acids. Methylparaben.5 is adapted to the skin’s protective acid mantle. suitable for therapy supportive skin cleansing in skin disorders. Poloxamer 101. Sodium Laureth Sulfate. Sodium Benzoate. and vitamins replenish the moisture balance of the skin.5 is adapted to physiological protective acid mantle of the skin. TEWL Corneometer 70 delta-values integrity (mean +/– SEM) (mean +/– SEM) (mean +/– SEM) 3 10 delta-values integrity day 14 baseline day 7 day 21 day 28 delta-g/m2 hr 60 2 5 50 1 40 baseline day 7 day 14 day 21 day 28 0 0 Delta Baseline Delta washing emulsion Delta water forearm-washing emulsion forearm-water check-washing emulsion forearm-washing emulsion forearm-water check-washing emulsion (Bornkessel et al 2005) Product range: Cleansing Bar An innovative soap-free. Thus it minimizes dehydration and irritation whilst providing pore-deep and refreshing cleansing. Lecithin. pH 5. Adapted to the physiological protective acid mantle of the skin. day 21) 4 n. CI 61570. Sodium Lauroyl Glutamate. Benzophenone-4. Panthenol. Glyceryl Stearate. Polyfructosan. Cocamidopropyl Betaine. Cocamide DEA. Palmitic Acid. Bioengineering methods were applied to measure skin function parameters. 500 ml and 1000 ml bottle with pump Ingredients: Aqua. . CI 47005. Hydrolyzed Wheat Protein. Isobutylparaben. Alanine. Magnesium Aspartate. Butylparaben. Sodium C14-16 Olefin Sulfonate. Disodium Laureth Sulfosuccinate. Glycine. Sodium Lactate. Sodium Citrate. Parfum. Stearic Acid. Lauryldimonium Hydroxypropyl Hydrolyzed Wheat Protein. Benzyl Alcohol. Sodium C1416 Olefin Sulfonate. Saccharide Isomerate. Sorbitan Laurate. MIPA-Laureth Sulfate. Glycol Distearate. Phenoxyethanol. Lysine. Parfum. Cera alba. Results of an in use test with sebamed Liquid Face & Body Wash sebamed Liquid Face & Body wash was used daily by 30 persons for 3 weeks. Phenoxyethanol. Lysine. Laureth-4. Ethylparaben. PEG-120 Methyl Glucose Dioleate. Liquid Face & Body Wash The soap-free wash emulsion with pH 5. Package sizes: 200 ml. Glycine. Sodium Laureth Sulfate. delta-values integrity (Baseline vs. Cleansing Shower Oil Soap-free moisturizing and emollient shower oil with a pH of 5. Sodium Lactate. Leucine. Inulin. Sodium Chloride. Patented Formula DE 198 435 47 – helps to alleviate dryness and irritability through its richness in oils – over 50 %. Allantoin. al.5 to stabilize the skin’s natural protective acid mantle and strengthen its physiological barrier function. CI 42090.16 17 sebamed soap-free skin cleansers For sensitive and problem skin – dermatologically tested For healthy total body hygiene sebamed offers a complete range of soap and alkali free cleansing products adjusted to the pH value of 5. Magnesium Aspartate. Niacinamide. Allantoin makes the skin smooth. Lysine. Allantoin. CI 42090. moisturizing vitamins and amino acids minimize dehydration and irritation (Bornkessel et al. amino acids. Laureth-2. Aqua. Skin tolerance and care efficacy are dermatologically tested. Recommended for sensitive and problem skin.1 – helps maintain the skin’s natural protective barrier function. Parfum. Alanine. Parfum. Sodium Cocoyl Glutamate. The pH 5. An effective moisturizing complex containing skin-related amino acids condition the skin to safeguard its moisture balance. Pentavitin. Glycine. Pyridoxine HCl. Dermatological tests have proven the suitability for sensitive and problem skin as well as therapy supportive skin cleansing in skin disorders (Bayerl et. Leucine. Magnesium Aspartate. comparing skin areas washed with water only to those washed with the test product. 2007). Tocopheryl Acetate. Talc. Together with panthenol they provide a unique skin feeling. Leucine. Cocamidopropyl Betaine.5. Ethoxydiglycol. Panthenol. Biotin. Package size: 200 ml bottle Ingredients: Aqua.5 adapted to the physiological protective acid mantle. Gentle and effective wash active substances combined with active treatment ingredients protect the skin from drying out. 2005). Lecithin. Revitalizing Foam Bath Combining mild cleansing with skin care the foam bath brings refreshment and relaxation for sensitive skin during bathing. Package sizes: 100 g and 150 g Ingredients: Disodium Lauryl Sulfosuccinate. PEG-55 Propylene Glycol Oleate. CI 77891. Alanine. especially avocado oil and lecithin – keeping the skin smooth and supple. Cetearyl Alcohol. Niacinamide.5 strengthens the skin's natural barrier function against moisture loss and irritants.5 cleansing formula – patent pending DBGM 2006008 552. CI 47005. Potassium Sorbate. 500 ml bottle with pump and 500 ml refill Ingredients: Persea gratissima oil.s. The pH value of 5. Propylene Glycol. Triticum vulgare starch. Paraffinum liquidum. Propylparaben. Sodium Benzoate. All sebamed products have a pH value of 5. Package sizes: 200 ml bottle. 400 ml. Its active organic wheat complex protect the elasticity of the skin. Glycerin. Free from preservatives and colors. CI 47005. Laureth-2.
pH 5. Parfum. Allantoin. PEG-7 Glyceryl Cocoate. Milan 2004 (unpublished results) Results: • No alteration of skin and mucous membranes in the application area • No dryness of skin and mucous membranes • Very good cleansing properties • Gentle cleansing action • Good deodorizing action • Pleasant to use Feminine Intimate Wash pH 6. Potassium Sorbate. Glyceryl Laurate. The natural calming and regenerative capacities of the herbal extract hamamelis virginiana combined with pathenol alleviate irritation and restore the physiological environment of the vulva. Parfum.8 with the skin-related lactic acid. Reliable therapy supportive feminine hygiene. PEG-120 Methyl Glucose Dioleate. Aloe barbadensis leaf gel. Hydroxypropylcellulose. A balanced skin care complex and high skin tolerability minimize the potential for irritation and allows frequent showering even in sensitive skin. Cocamidopropyl Betaine. CI 42090.5 adapted to the physiological protective acid mantle of the skin. Sodium Laureth Sulfate.8 is a gentle and effective. Sodium Lactate. Propylene Glycol. average age 39 years washed their genitoanal area at least once daily with sebamed Feminine Intimate Wash pH 3. Glycine. Phenoxyethanol. CI 61570. Glycerin. The natural presence of glycogen and lactic acid in the genital ecosystem defined the formulation of Feminine Intimate Wash pH 3.5 skin cleansing formula provides the ideal basis for well-being during showering. Butylene Glycol.8 Clinical test of sebamed Feminine Intimate Wash pH 3. Panthenol. sebamed Feminine Intimate Wash Two stages in a woman’s life Sensitive: pH value 3. soap-free. Hamamelis virginiana bark/ leaf/ twig extract.8 maintain the biological equilibrium of the micro-flora in this sensitive area as essential prophylactic protection against bacterial and fungal infections during the child-bearing years. Limonene. Sodium Lactate. Alanine. Moisturizing allantoin and lactic acid supplemented with water lily extract leave the skin smooth and supple. PEG-120 Methyl Glucose Dioleate. Bisabolol. Lysine. Package size: 200 ml bottle Ingredients: Aqua. Sodium Citrate. Hexyl cinnamal. Magnesium Aspartate. Lauryl Glucoside.8 30 women. Sodium Benzoate. Piroctone Olamine. Butylphenyl Methylpropional. Feminine Intimate Wash pH 3.8 for 30 days. Sodium Benzoate. Benzyl Alcohol.8 for optimal hygiene at the on-set of menopause Product range: Spa Shower Excellent skin tolerance through a mild. Disodium Cocoamphodiacetate. Disodium Laureth Sulfosuccinate. Parfum. Particularly suited for sensitive skin and frequent showering. The organic derivative tenside complex provides mild cleansing to safeguard against dryness. Package size: 200 ml bottle Ingredients: Aqua. Leucine. Linalool. Allantoin. Package sizes: 200 ml bottle Ingredients: Aqua. Disodium Laureth Sulfosuccinate. Disodium Cocoamphodiacetate. Package sizes: 200 ml. Glyceryl Laurate. The natural and gentle cleansing action of Feminine Intimate Wash and its acidic pH value of 3. Glycerin. Aloe barbadensis activates the moisture balance of the mucous lining with its natural moisturizing capacity. therapeutic supportive wash emulsion for natural intimate hygiene during the child-bearing years. Assessment of cosmetic capacities: The candidates evaluation of the product was predominantly excellent to good. Sodium Lactate. For persons with dry or extremely sensitive skin the application of a skin care lotion after showering is recommended. Gently cleanses the skin and makes it smooth and soft. Washing capacity 100% excellent to good Mildness Deodorant capacity Texture Fragrance 93% excellent to good 90% excellent to good 83% good to excellent 80% excellent to good Piarotti. Cocamidopropyl Betaine. Parfum.8 At the on-set of menopause lactic acid production by vaginal latobacillae subsides with the estrogen levels. Sodium Benzoate. sebamed Feminine Intimate Wash pH 3.8 specific for the micro-flora balance during the child-bearing years Menopause: Adjusted to the pH value of 6. Dermatologically tested. The soothing antibacterial property of alpha bisabolol. a notoiceable soothing effect and analgesic properties. Cocamidopropyl Betaine. the active ingredient of the medicinal plant camomile prevents irritation and cares for the skin. Caramel. PEG-55 Propylene Glycol Oleate. . For all skin types. Sodium Lauroyl Glutamate. Protects the skin's acid mantle and barrier function. Cocamidopropyl Betaine. Niacinamide. PEG-18 Glyceryl Oleate/Cocoate. Phenoxyethanol. CI 47005. PEG150 Distearate. Nymphaea alba flower extract. In the initial development of Feminine Intimate Wash a panel of 80 female gynaecologists personally tested the efficacy and skin tolerability of the product giving high notes for tolerance. resulting in a rise in pH between 6 to 7 and possible dryness of the mucous linings.18 19 sebamed skin cleansers Product range: Fresh Shower Soap-free shower gel with a pH value of 5. Sorbic Acid. Phenoxyethanol. Sodium Laureth Sulfate. 400 ml and 1000 ml bottle with pump Ingredients: Aqua.
C12-15 Alkyl Benzoate.05 in comparison with blank control ** p < 0. In-use test of sebamed For Men After Shave Balm 3-week test with 40 men. with a pH value of 5. Cetearyl Alcohol. without vitamin E demonstrated the efficacy of this active ingredient (Zhai et al. Sodium Citrate.5. Phenoxyethanol. 2005) Product range: Moisturizing Cream Moisture and emollience make the skin smooth and supple. 2006.. Acrylates/C10-30 Alkyl Acrylate Crosspolymer.3% Tocopheryl acetate to counteract oxidation stress to the skin. 75 ml. dryness. Sodium Benzoate. Benzyl Alcohol. Parfum. 2003). Parfum. In vivo effect of sebamed Moisturizing Cream with vs. With their active skin care ingredients and the pH value of 5. to help solve skin problems and are a useful supplement for skin therapy in skin disorders. Brassica campestris Sterols.05 in comparison with vehicle control (Zhai et al. without vitamin E on UV-induced erythema Free-radical scavenging effect of sebamed Moisturizing Cream Skin Blood Flow Volume (BFV) 30 Visual Scores (Erythema) 2 * 1.5 they alleviate irritation and dryness. Sodium Citrate. 100 ml jar Ingredients: Aqua.5 to match the physiology of the skin. sebamed After Shave Balm restores the natural barrier and defends against. irritation. roughness. The balm is easily applied and rapidly absorbed without residue. Glycerin. the cream offers valuable cellular protection. Excellent skin tolerability in sensitive skin. Packaging size: 50 ml tube. Package size: 100 ml tube Ingredients: Aqua. and other symptoms were ameliorated (Sera-Baldrich et al.20 21 sebamed protective care products For sensitive and problem skin Individual and regular skin care is the skin's best defense against noxious external influences. Benzyl Alcohol. Sodium Carbomer. 2002)..5 0 Day 2 Day 3 Days 0 Day 2 Day 3 Days Vitamine E emulsion Vehicle control Blank control * p < 0. leaving the skin smooth and supple. The benefits of the cream for skin care were further confirmed in a test on 25 women over three weeks. Bisabolol.** 10 * * 0. Phytosterols and bisabolol relieve stinging and redness. With its high content of 2. Octyldodecanol.** * BFV (a. Sorbitol. daily use. unpublished data) . Suitability as After Shave 17 18 11 17 15 0 5 10 15 20 23 22 excellent good 29 For Men After Shave Balm Calming and smoothing skin care relieves discomfort of facial skin in men with sensitive skin after shaving.5 *. Effect on skin irrtiation Skin tolerance Effect on the state of the skin Skin care effect 23 25 25 30 (Worret. Sodium PCA.) 20 * Visual Scores (0-4) 1 *.u. In vitro radical scavenging effect of sebamed Moisturizing Cream with vs. Petrolatum. Tocopheryl Acetate. Dimethicone. Glyceryl Stearate Citrate. and body. This is why sebamed has developed special products for the face. and harmful bacteria or fungi with the help of its pH 5. Menthol. Glycerin. hands. Ceteareth-20. sebamed Moisturizing Cream has demonstated its skin care efficacy and tolerance in sensitive skin through dermatological study. The moisturizing complex increases the lipid content and hydration of the skin. The state of the skin. Myreth-3 Myristate.5. dryness.. Phenoxyethanol. and its pH value of 5.
Caprylyl/Capryl Glucoside. Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer. 1995. Hexyldecyl Laurate. hydrating care of the skin. Sodium Citrate. Sorbitol. Cetyl Palmitate. Butyrospermum parkii. Steareth-21. while the pH value of 5.5 support the skin's acid mantle and barrier function. Panthenol. Derma Hydrating Body Gel The light oil-free texture of Derma Hydrating Body Gel is rapidly absorbed by the skin and non-occlusive. Sodium Carbomer. The high skin tolerability of Derma Hydrating Body Gel relieves skin irritation after shaving and depilation. Sodium Citrate. Phenoxyethanol. Tocopheryl Acetate. Ceteareth-20. Package sizes: 75 ml Ingredients: Aqua. Sodium Citrate. Propylparaben. Cetearyl Alcohol. Glyceryl Cocoate. Sodium Hyaluronate. The skin is refreshed and revitalized. Panthenol.5 stabilizes the nail structure. Hexyldecanol. Derma Hydrating Body Gel provides immediate soothing regeneration and restores the moisture balance of the skin. Aloe barbadensis leaf gel. Furthermore. Sodium Lactate. In a dry skin condition Derma Hydrating Body Gel can be used as an additional basic hydrating treatment before sebamed Body Milk in aiding the skin to regain its equilibrium. Sodium Carbomer. sports. Kosmetische Medizin 1998) An innovative and patented product Patent No. C12-15 Alkyl Benzoate. Glycerin. Petrolatum. Sodium Citrate. Benzyl Alcohol. The active ingredient Dehydrosal restores normal hydration levels and the barrier function within minutes afer application.5. Glycerin and the pH value 5. Glycerin. Hydrolyzed Keratin. an oil-in-water emulsion with a pH value of 5. Glycerin. Measurement of hydration at least 10 hours after the last application of sebamed Body Milk after 2 weeks of daily use 50 (Niedner. Allantoin. Dermatological in-use test in 28 employees and patients of the dermatological clinic of the Potsdam University over 3 weeks with repeated daily use of the Hand & Nail Balm. Its stabilizing effect on the barrier function and its active moisturizing ingredients make the skin soft and smooth. Ascorbyl Palmitate. Glyceryl Stearate. Phenoxyethanol. Olympic athletes have found the lotion effective against skin problems resulting from high levels of perspiration and in preventing skin dryness. Parfum. Butyrospermum parkii butter. In-vitro test of deswelling efficacy of Dehydrosal Comparison of the anti-swelling effect of Dehydrosal and other active ingredients in frozen sections of human skin after incubation with Sodium Laurylsulfate (Gehring 2006) . Propylene Glycol. Caprylyl/Capryl Glucoside. smooth and refreshed. Caprylic/Capric Triglyceride.. Prunus dulcis oil. A lotion for sensitive skin. Sorbitol. Allantoin. Betaine. Ceteareth-25. CI 47005. Regular use of sebamed Anti-Swelling Hand Balm after wet work or glove removal also reduces and prevents irritation. Polyisobutene. Sodium Cetearyl Sulfate. As skin swelling is a well-established predisposing factor for hand eczema in occupational as well as in household. Parfum. CI 42090. Soaks in rapidly and completely after the application without any greasy residue. Sorbitol. Sodium Benzoate. D-Panthenol supports regeneration and helps to regain the moisture balance of dry skin. The balm moisturizes dehydrated hands and nails. leaving the skin soft. Aluminium Chlorohydrate. Chamomilla recutita. Dimethicone. Ceteareth-12. Phenoxyethanol. PPG-2 Myristyl Ether Propionate. The quick and complete absorption of the balm by the skin encourages its regular use at home and at work. and other private settings. Phenoxyethanol. Intensive body care with shea butter and jojoba oil to moisturize and smooth the skin without leaving a greasy film. Cetearyl Alcohol. which does not tolerate oils and emulsifiers this light gel is suitable for balancing. the pH value of 5.5. EP 1364651 B1 was designed to reverse skin swelling after wet work and wearing of occlusive gloves. In-use test of sebamed Hand + Nail Balm Body Milk Moisturizes and protects dry skin. Clinical tests demonstrated a 26% increase in skin hydration. Package sizes: 100 ml with pump Ingredients: Aqua. Benzyl Alcohol. Sodium Aluminium Chlorhydroxy Lactate. Sodium Citrate.5 supports the maintenance of the skin´s acid mantle and its vital protective capacity. Phenoxyethanol. Methylparaben. Hand + Nail Balm Moisturizing oil-in-water balm for stressed hands and nails. thus protecting it from environmental noxes. Bisabolol. Steareth-2. 140 130 120 110 100 90 80 start 1 2 3 weeks Increase in skin hydration In-use test of sebamed Body-Milk 3 week in-use test in 30 persons with dry skin. Package size: 200 ml and 400 ml bottle Ingredients: Aqua. Decyl Oleate. Package size: 200 ml and 500 ml bottle with pump Ingredients: Aqua. Allantoin. Alcohol. Simmondsia chinensis. unpublished data) Skin hydration (Corneometer values) normal skin dry skin after 2 weeks 48 Anti-Swelling Hand Balm 45 40 before use of Body Milk 38 (Greif et al. Hydrogenated Coconut Oil. Lecithin. Paraffinum liquidum. Sorbitan Oleate. with a pH-value of 5.5 stabilizes the skin's barrier function and acid mantle. Parfum.22 23 Moisturizing Body Lotion Moisturizing oil-in-water emulsion with a pH value of 5. Glycerin. Hydrogenated CocoGlycerides. Panthenol. Parfum. Parfum.5. a solution is urgently needed. For problematic skin. Package size: 200 ml bottle Ingredients: Aqua. Its pH value of 5.
The pH value of 5. Lauryldimonium Hydroxypropyl Hydrolyzed Wheat Protein. Hydrolyzed Silk.24 25 sebamed hair care system For sensitive scalp and hair problems A sensitive and problematic scalp as well as structurally damaged hair require special care. Sodium Citrate. Hydrolyzed Wheat Protein. Cocamidopropyl Betaine. 0 -10 -20 -30 -40 Product range: Everyday Shampoo Contains a sugar-based tenside agent and an active moisturizing compound for specially gentle cleansing action to protect and stabilize the hair’s structure and the health of the scalp. styling. The high tolerability and efficacious dandruff control properties of its active ingredient Piroctone Olamine dislodges dandruff gently and reliably so that the skin can breath.5 of the sebamed hair care system supports the physiological acid mantle of the scalp and the barrier function against dehydration.5 for prevention of hair and scalp dehydration and strengthening of the physiological acid mantle. Hydrolyzed Soy Protein. It also strengthens the keratin structure of the hair. Parfum. Cetrimonium Chloride. coloring. Ceteareth-12.5 cleansing formula rinses off excess oil without causing dryness or irritation of the scalp. Package size: 200 ml and 400 ml bottle Ingredients: Aqua. Sodium PCA. Phenoxyethanol. Sodium Benzoate. Benzyl Alcohol. unpublished data) Anti-Dandruff Shampoo Gently and thoroughly cleanses oily dandruff prone scalp. hot blow-drying and sun. Hydroxypropyl Oxidized Starch PG-Trimonium Chloride. Biopolymers encase the hair shaft with a micro-film to protect the hair and restore structural damage. Hair Repair Conditioner Moisturizing Panthenol and Hydrolyzed Silk together with selected plant extracts give the hair a healthy shine and make it easier to style. Sodium Lactate. Zürich 2005. PEG-18 Glyceryl Oleate/Cocoate. Combined with a mild sugar surfactant complex allows for regular use. Amodimethicone. Package sizes: 200 ml and 400 ml bottle and 1000 ml bottle with pump Ingredients: Aqua. CocoGlucoside. Sodium Lauryl Sulfoacetate. Humulus lupulus extract. High skin tolerabilitiy for frequent hair washing even with a sensitive scalp or by dry and damaged hair. Chamomilla recutita flower extract.. penetration of irritants. and pathogenic microorganisms. damaged hair. Hydroxypropyl Oxidized Starch PG-Trimonium Chloride. Foeniculum vulgare fruit extract. sebamed Repair Shampoo contains a highly effective repair complex of plant-based active ingredients to cleanse. Disodium Laureth Sulfosuccinate. Parfum. Sodium Benzoate. Sodium Cetearyl Sulfate. Alcohol denat. Particularly suitable for dry. Glycerin. Trideceth-12. Piroctone Olamine. Persea gratissima oil. Propylene Glycol. Sodium Lactate. Parfum. Sodium Laureth Sulfate. Package size: 200 ml bottle Ingredients: Aqua. Glyceryl Oleate. Hydroxypropyl Guar Hydroxypropyltrimonium Chloride. Sodium Lauroyl Sarcosinate. . Cetyl Alcohol. Laureth-4. Ethoxydiglycol. Sodium Chloride. Phenoxyethanol. The mild. moisturize and protect hair and scalp. Palmitoyl Hydrolyzed Wheat Amino Acids. Sodium Lactate. Package sizes: 200 ml and 400 ml bottle and 1000 ml bottle with pump -37% -47% scalp irritation -50 dryness of hair -49% dryness of scalp (Trüeb. Laureth-2. Efficacy of sebamed Repair Shampoo on hair and scalp In-use test in 25 persons with dry hair and scalp % change in evaluated average scores within 3 weeks of regular use of sebamed Repair Shampoo Ingredients: Aqua. To be used after washing of the hair and rinsed off before drying and styling. Propylene Glycol. Glycol Distearate. The pH value of 5. pH 5. Disodium Laureth Sulfosuccinate. Effectively combats the proliferation of dandruff causing Pityrosporum ovale for immediate relief of scalp irritation. Sodium Benzoate. Repair Shampoo sebamed Repair Shampoo was developed specially for structurally damaged hair. Sodium Laureth Sulfate.5 stabilizes hair and scalp. Melissa officinalis leaf extract. Achillea millefolium extract. Decyl Glucoside. With a pH value of 5. Phenoxyethanol. Cetearyl Alcohol. Sodium Benzoate. Viscum album leaf extract. PEG-55 Propylene Glycol Oleate. Sodium C14-16 Olefin Sulfonate. Natural protein and moisturizers regulate the moisture balance of the hair and scalp. Structural damage can be caused by perming. Polyquaternium-16. Lauryl Glucoside. Panthenol. Parfum.
colors and preservatives. Sodium Citrate. Measurements of skin hydration. Talc absorbes moisture. Aqua.5 provide reliable. Package size: 75 ml pump spray. Parfum. blossom. Disodium EDTA. Squalane. Caprylyl Glycol. Sodium Malate. safe Supression of body odour forming bacteria by active ingredients and pH 5. Parfum. gentle. Parfum. Hydroxypropylcellulose. long-lasting protection from unpleasant body odour without interfering with the function of the sweat glands. Xanthan Gum. Acrylates/C10-30 Alkyl Acrylate Crosspolymer. Package sizes: 75 ml pump spray. surface lipids. Xanthan Gum. Zinc Ricinoleate. Balsam Deodorant An extra-mild skin care formula to protect even the most sensitive skin from body odour without irritation. Zinc Ricinoleate. whereas an increase in skin surface lipids proved an emollient effect. For all skin types. with allantoin to protect and smooth the skin. Gentle enough for sensitive skins.ethanol Roll-on: Aqua. Candida bombicola/Glucose Methyl Rapeseedate Ferment. Sodium Citrate. Free from aluminium. Phenoxyethanol. Squalane. Polysorbate 20. . Parfum. Triethyl Citrate. Talc. hydration and pH. Disodium EDTA. TEWL and pH were performed on the forearm skin as the axillae yields no reliable data. Gentle. Candida bombicola/Glucose Methyl Rapeseedate Ferment. Allantoin. Triethyl Citrate. the right forearm was left untreated to serve as a control. without alcohol. 50 ml roll-on Ingredients: Spray: Alcohol. Pentylene Glycol. Scent: lime. Product range: 24 h Care Deodorant The first deodorant with a trilipid formulation for the best skin tolerability. Triethyl Citrate. Sodium Citrate. Acrylates/C10-30 Alkyl Acrylate Crosspolymer. Free from alcohol and aluminium salts. 50 ml roll-on Ingredients: Spray: Aqua. Sodium Malate. reliable protection from body odour 24 hours. 24 h protection from body odour with superior skin tolerance for sensitive skin is achieved by combining an anti-bacterial active ingredient with an odour absorber and the emollient squalane. There was no difference between untreated and deodorant-treated skin in term of barrier function (TEWL). Clinical in-use test of sebamed Balsam Deodorant sensitive 30 test persons with sensitive skin according to a facial stinging test with 10% lactic acid used the deodorant daily for 3 weeks in the armpits and on the left forearm. Allantoin. Dermatologically tested. Roll-on: Aqua.26 27 sebamed Deodorants for sensitive skin Natural. Jung. 6 0 1 2 3 weeks (Keil. Triethyl Citrate. Caprylyl Glycol. Package sizes: 50 ml roll-on Ingredients: Aqua. Bayerl. Talc. indicating an excellent skin compatiblity of the product. Sorbitol. Alcohol. Polysorbate 20. Phenoxyethanol. Parfum. 2002) For Men Balsam Sensitive Without aluminium salts. Parfum. Pentylene Glycol. Xanthan Gum. Change in transepidermal water loss (TEWL) 10 left forearm – with deodorant right forearm – without deodorant TEWL (g/cm2xh) 8 Fresh Deodorant Prevents body odor without affecting the natural function of the sweat glands. Sodium Citrate. Dermatologically tested by men with sensitive skin. The active formula trisoft combines an inhibitor of odour-causing bacteria with an odour absorbent agent and the protective lipid squalane. active. Package size: 50 ml roll-on Ingredients: Aqua. All sebamed deodorants are free from aluminium salts to provide maximum skin tolerance. Scent: fresh.
Allantoin. papules/pustules – 54%. Cera alba. PEG-120 Methyl Glucose Dioleate. Package size: 200 ml and 400 ml with pump Ingredients: Aqua. Therefore. Panthenol. Microbial colonization of the skin by apathogenic species is controlled by the acid mantle. A moisturizing and skin care complex with panthenol and lecithin protect further against dehydration. Sodium Laureth-6 Carboxylate. seborrhoic dermatitis of the scalp etc. Parfum.1 – with an amino acid based surfactant compound of sodium lauroly sarconsinate and cocamidopropyl betaine combines with the natural skin-related oligosaccharide inulin for the gentle cleansing of baby’s delicate skin. Disodium Lauryl Sulfosuccinate. Sodium Lactate. Disodium Laureth Sulfosuccinate. in preparation) Baby Wash extra soft A newly developed. A 100% soap and alkali free mild emollient formula for excellent skin tolerance. Squalane. Sodium Laureth-6 Carboxylate. Parfum. Propylene Glycol. Skin surface lipids increased markedly while pH remained constant. Benzyl Alcohol. Magnesium Aspartate. PEG120 Methyl Glucose Dioleate. Benzyl Alcohol. Lecithin. Sodium Methyl Cocoyl Taurate. stinging –81%. Cocamidopropyl Betaine. Glyceryl Laurate. Parfum. PEG-18 Glyceryl Oleate/Cocoate. Children’s Shampoo For the delicate scalp and fine hair of babies and children from birth to adolescence. diaper rash. The protective acid mantle develops during the first weeks of life. and hydration decreased slightly over the observation period. highly efficient moisturizers for emollients. Package size: 250 ml.) over a 4 week period of use 35 30 25 20 15 10 5 0 32 26 dry normal 16 14 7 3 Initial Intermitted examination examination Final examination (Molnar et al. . Chamomilla recutita extract. Sodium Benzoate. which thus prevents skin infections. K. Laureth-4.5 promotes the development of the scalp’s physiological acid mantle. Sodium Benzoate.5. Cocamidopropyl Betaine. Leucine. Inulin. Phenoxyethanol. Cocamidopropyl Betaine.5 formula reduces the drying and irritating effects of cleansing on sensitive baby skin. The pH value of 5. Package size: 150 ml and 250 ml bottle and 500 ml bottle with pump Ingredients: Aqua. but remains less stable and resistant until adolescence. Phenoxyethanol. Squalane (a vernix related lipid) and vitamin E substitute moisture lost by cleansing. Panthenol. flaking –67%. Glycol Distearate. Alcohol. The incidence of dry skin in the panel decreased in favor of normal skin during the use of the bubble bath. PEG-55 Propylene Glycol Oleate. To be added to the baby bath after the navel has healed. PEG-7 Glyceryl Cocoate. as did clinical scores for skin symptoms: eyrthema – 57%. Dermatological in-use test of Baby sebamed Bubble Bath Product range: Baby Cleansing Bar cleansing bar – Patent Pending: DBGM 2006 008 551. Test in 30 children (age 8 – 20 months) with skin problems (atotpc dermatitis. Glyceryl Stearate. Chamomilla recutita extract. To be used for washing from head to toe from the very first day. The pH value of 5. soap-free. creating a soft and supple skin feeling.5 supports the development of the still instable acid mantle. Alcohol. Talc. Alanine. Stearic Acid. Dermatologically tested. Sodium Lactate. and maximum skin tolerance. Baby Bubble Bath The extra mild soap and alkali free tenside complex combines with emollients. during the early stages in life. Disodium Cocoamphodiacetate. Lysine. and soothing chamomile to provide gentle cleaning for sensitive baby skin and protect it from dryness and irritation. Glycine. moisturizers. Sodium C14-16 Olefin Sulfonate. Cetearyl Alcohol. tension – 90 %. Package size: 100 g and 150 g Ingredients: Triticum vulgare starch. Disodium Cocoamphodiacetate. Decyl Glucoside. dryness – 57%. Aqua. Phenoxyethanol. Sodium Benzoate. Sodium Lactate. CI 77891. 500 ml Ingredients: Aqua. baby requires cleansing and skin care formulated with a pH value of 5.28 29 Baby sebamed The best protection from the very first day Baby skin is extremely sensitive and dehydrates easily due to its loose and soft structure. Palmitic Acid. pH 5. Sodium Lactate. xerosis. Magnesium Sulfate. Parfum. Sodium Lauroyl Sarcosinate.
Parfum. Propylene Glycol Dicaprylate/Dicaprate. Lecithin. Sodium Cetearyl Sulfate. shea butter. Hydroxyoctacosanyl Hydroxystearate. Alcohol. Panthenol. Cetyl Palmitate. PEG45/Dodecyl Glycol Copolymer. Body Milk The 23% natural lipid complex of sweet almond oil. Hexyl Laurate. Package size: 200 ml bottle Ingredients: Aqua. Squalane. Propylene Glycol Dicaprylate/Dicaprate. Vienna. Cera microcristallina. Parfum. Phenoxyethanol. very dry 5 normal oily In-use test of sebamed Baby Wash extra soft and Baby Body-Milk 30 number of babies 25 20 15 10 5 0 before use after 1 week after 2 weeks after 3 weeks 3 0 0 0 0 0 0 0 0 15 12 7 6 Body Skin 23 24 28 TEWL (g/cm2 x h) 10 cheek forehead dry 30 number of babies 25 20 15 10 5 0 Facial Skin 20 30 26 28 0 0 1 2 3 weeks 8 4 2 0 0 0 0 0 0 0 0 0 (Keil D. Alcohol. regenerating the skin to counteract irritation. Panthenol. CocoCaprylate/Caprate. Panthenol. Squalane. Sodium Lactate. Prunus dulcis oil. Soothing Massage Oil Pure oil based on soy and plant lipids together with wheat germ extract provides smoothing an protective skin care. Triticum vulgare extract. Caprylic/Capric Triglyceride. Phenoxyethanol. the active ingredient panthenol stimulates the healing process. Sodium Citrate. Glycerin. Well suited for the prevention of nappy rash dermatitis. Parfum. Vitamine E. Sodium Carbomer. Butyrospermum parkii butter. Sodium Cetearyl Sulfate. Dimethicone. Sodium Carbomer. Cetearyl Alcohol. Titanium Dioxide. Package size: 100 ml and 200 ml tube Ingredients: Aqua. providing rapid relief and reliable pprotection in mild forms of nappy dermtitis. Lecithin. Squalane. exept for superinfected forms. Sodium Lactate. Glycerin. Sorbic Acid. Lecithin. Chamomilla recutita extract. The cream was applied once or twice daily on the face for 3 weeks. Allantoin. Dimethicone. and make baby’s skin soft and smooth. Cera alba. Paraffinum liquidum. Parfum. Glycerin. Phenoxyethanol. Allantoin. Sodium Citrate. The Pediatrician. skin-related squalane and lecithin is easily absorbed by the skin to promote its hydrolipid balance without harmful occlusive effects. unpublished study 2005) before use after 1 week after 2 weeks after 3 weeks (Dermatological in-use test by Prof. Sodium Hyaluronate.30 31 Protective Facial Cream The pleasantly light oil-in-water emulsion efficiently protects the sensitive facial skin of the baby against dryness and irritating environmental influences without occlusive effects. . Squalane. Sodium Lactate. Change in transepidermal water loss 15 Sebamed Baby Wash was tested together with sebamed Baby Body Milk on 30 babies at the Pediatric Clinic of the Vienna University by Prof. Petrolatum. Ascorbyl Palmitate. Polyglyceryl-2Sesquiisostearate. Ascorbyl Palmitate. Sorbic Acid. The 36% lipid compound including lecithin. Sorbitol. Triticum vulgare extract. Benzyl Alcohol. Braun for 3 weeks. Package size: 200 ml and 400 ml with pump Ingredients: Aqua. PEG-20 Methyl Glucose Sesquistearate. Xanthan Gum. 1999) Diaper Rash Cream Baby Cream extra soft For the intensive protection of baby’s sensitive skin. Chamomilla recutita extract. Panthenol. Package size: 150 ml bottle Ingredients: Glycine soja oil. Sodium Benzoate. C12-15 Alkyl Benzoate. Caprylic/Capric Triglyceride. Allantoin and hyaluronic acid combine to keep the skin soft and supple and relieve dryness or irritation. Polyglyceryl-3 Methylglucose Distearate. the nurses. Tocopheryl Acetate. The oil is formulated to allow sufficient gliding properties for gentle baby skin massage to combine the product’s care acitivities with the well-established beneficial effects of massage. Disodium EDTA. Benzyl Alcohol. without occlusive effects. this rich water-in-oil emulsion with 42% lipids forms a protective and moisturizing film. Dermatologically/clinically tested. In-use test of Baby sebamed Protective Facial Cream sebamed Baby Facial Cream was tested in a dermatological practice on 20 children between 5 months and three years of age in summer 2005. Dimethicone. and the parents evaluated the products. Methyl Glucose Sesquistearate. Phenoxyethanol. Parfum. Strongly indicated for skin conditions effecting the nappy area. Allantoin. Cetearyl Alcohol. Panthenol. Sorbitol. Petrolatum. Braun. Methoxy PEG-22/Dodecyl Glycol Copolymer. Phenoxyethanol. Decyl Oleate. propylene glycol and sorbitol enhance the skin’s hydrolipid balance. Paraffinum liquidum. Oleyl Erucate. Paraffinum liquidum. Sodium Benzoate. Sodium Citrate. Package size: 50 ml. It is rapidly absorbed by the skin without greasy residue. 200 ml and 300 ml tube Ingredients: Aqua. Package size: 100 ml pump container Ingredients: Aqua. Ascorbyl Palmitate. Sodium Citrate. Benzyl Alcohol. Parfum. Allantoin. Glycerin. Caprylic/Capric Triglyceride. which is part of the skin’s hydrolipid system and skin-related squalane help to create a protective barrier against aggressive substances. Baby Lotion The moisturizing and emollient complex with 7% lipids safeguards the delicate baby skin against dryness. Allantoin and a high concentration of panthenol actively regulate the skin’s moisture content. Allantoin.
Vitamins. Panthenol. 1989) . Package size: 150 ml bottle with pump applicator Ingredients: Aqua. Lysine. Reduced roughness Profilometric values for roughness 30 Antibacterial Cleansing Foam 20 15 5 Thorough cleansing without dehydration with the patented active ingredient Montaline® C40 which has an antibacterial effect. Stearic Acid. Talc. Package size: 100 g Ingredients: Disodium Lauryl Sulfosuccinate. CI 77891. or support their rapid healing. amino acids and active moistureres help to rebalance the moisture content of the skin. Sodium Lactate. blackheads and skin impurities. Sodium Lauroyl Sarcosinate. Sodium Lactate. Cocotrimonium Methosulfate.6 10 5. Phenoxyethanol. More severe cases profit from therapy supporting skin care by avoiding dryness and irritation and adding to the treatment success. atopic eczema Reduced erythema Chromameter values for redness 6.4 25 6. Removes excess oil without causing dryness or irritation in sensitive acne skin and helps reduce acne lesion. Cocamidopropyl Betainamide MEA Chloride. Inulin. 15 Reduced roughness Profilometric roughness values 12 40 9 30 6 20 3 10 0 before cream application after 4 weeks after 8 weeks 0 before start of skin care after 4 weeks after 8 weeks Product range: Baby sebamed Cream extra soft untreated Cleansing Bar Need for skin care due to e. Cera alba.5 to support the biological barrier function of the acid mantle Panthenol hydrates the skin and supports the healing of skin lesions. 0 before skin care after 4 weeks after 8 weeks (Budde et al.6 6.8 5. Cocamidopropyl Betaine. Glycine. Tocopheryl Acetate. Glyceryl Stearate. Magnesium Aspartate. Lecithin. Parfum. Aqua. Cetearyl Alcohol.2 6 5..2 5 before skin care after 4 weeks after 8 weeks New soap free amino acid based formula – Patent Pending: DBGM 2006 008 551.4 5. Adjusted to the skin’s natural pH value of 5.g. Parfum. In mild cases it is able to prevent the formation of non-inflammatory lesions and as a consequence the development of papules and pustules. Leucine. dequamation and dirt particles.1 – with Inulin for effective deep cleansing of combat pimples. Palmitic Acid. High skin tolerability ensures gentle pore deep cleansing to remove excessive sebum. The reduction of comedones and inflammatory lesions has been demonstrated in a dermatological test. Triticum vulgare starch.32 33 Amelioration of erythema and roughness in children‘s skin by Baby sebamed Cream Extra-Soft Test in 80 children aged 9 months to 6 years after medication or for skin care alone Skin care after medication Reduced erythema: Chromameter values for redness 50 sebamed Clear Face Therapy supportive skin care for acne-prone skin Adequate skin care is crucial. Alanine.
34 35 sebamed Clear Face Antibacterial Cleansing Foam reduces acne lesions 30 test persons with acne used sebamed Clear Face Cleansing Foam for daily facial cleansing for 4 weeks. CI 77891.cucumber extract and hydrolyzed silk . Glycerin.5 14. Alcohol. The toner removes excess sebum thoroughly.5 naturally protects against the proliferation of acne bacteria. Potassium Sorbate. Brassica campestris Sterols. Glycerin. coarse and flaky. The oil compounds in creams and lotions encourage the development of blackheads and pimples.4 4 4 3 2 2 1. Although acne skin produces too much sebum it is often dry. Behenyl Alcohol. Ingredients: Aqua. Package size: 50 ml tube. Pentylene Glycol.7 1. Package size: 150 ml bottle Ingredients: Aqua. Butyrospermum parkii butter. Reduces inflammation and dries out pimples. Sodium Benzoate. and allantoin in combination with panthenol support the healing process. relax and calm the distressed skin. with a pH value of 5. Chloroxylenol. Allantoin and witch hazel smooth and calm the skin. Cetearyl Alcohol.5. Parfum. Panthenol. CI 77499. Camouflages irritation and offers effective relief from pimples. sebamed Clear Face Care Gel contains allantoin. papules 8 pustules 5 4 7. Parfum. The pH value of 5. Hydrolyzed Silk.5 18.2 4. Sodium Citrate. Panthenol. Sodium Citrate. Sodium Hyaluronate. Bisabolol. tight. Propylene Glycol. Free from oils. Witch hazel extracts and bisabolol reduce the inflammation. The anti-bacterial effect of chloroxylenol and alcohol eliminates the inflammatory stimulus. Jung. Simmondsia chinensis oil. Alcohol. Glycerin. hyaluronic acid and aloe to smooth.3 Through direct application to inflammatory lesions its anti-bacterial effect accelerates the healing process markedly.9 16.5 20. Xanthan Gum. Propylene Glycol. Ingredients: Aqua.protect against dryness. Panthenol and allantoin support the regeneration of the skin. Sodium Citrate. Aloe barbadensis leaf gel. Sorbitol. Sodium Benzoate. Allantoin. Phenoxyethanol. Panthenol.5 Anti-Pimple Gel 6 4. Parfum. Tocopheryl Acetate. Cucumis sativus fruit extract.5 stabilizes the acid mantle to combat pimple causing bacteria. The number of lesions per half side of the face were counted Care Gel closed comedones 30 25 20 15 10 5 0 initial after 4 weeks open comedones 30 25 25. Panthenol.6 20 15 10 5 0 initial after 4 weeks A mild gel for problem skin and for persons with acne. emulsifiers and colorants. 1 0 initial after 4 weeks 0 initial after 4 weeks (Keil. Panthenol clears up inflammation quickly.5. Caramel. . Polysorbate 20. Sodium Carbomer. Sodium Carbomer. Glyceryl Stearate SE. CI 42090. showing comedones. Sorbitol. acne papules .1 13. Potassium Sorbate. The acne bacteria are inhibited by the pH value of 5. Package size: 10 ml tube. and pustules. Panthenol supports the skin’s regeneration. Hydroxypropyl Oxidized Starch PG-Trimonium Chloride. Hamamelis virginiana bark/ leaf/ twig extract. Caramel. CI 77492. Polysorbate 20. Sorbic Acid.5 and the alcohol content of the toner. Natural protection against pimples with the pH value of 5. The active natural skin care ingredients . CI 77491. Squalane. Propylene Glycol. Bayerl 2002) Coloured Anti-Pimple Cream Deep Cleansing Toner Pore-deep cleansing for the removal of excess sebum and bacteria. Sodium Lactate. Allantoin. Ingredients: Aqua. Cucumber extract and hydrolyzed silk hydrate and smooth the skin. preventing the development of new pimples. Package size: 10 ml tube. The pH value of 5. Hydrolyzed Silk. Cucumis sativus fruit extract. Hamamelis virginiana bark/ leaf/ twig extract. Cetearyl Glucoside. Allantoin. C12-15 Alkyl Benzoate. Alcohol. Chloroxylenol.
facial care and body care with phytosterols from rapesseed oil. or medications affecting the skin like chemotherapy. roughness. For this reason.6 38. or directly after extensive bathing and towel drying is necessary to maintain the labelled SPF. sensitive. it is important to reapply the sun care product. The skin absorbs UV-A (long-wave ultraviolet radiation) and UV-B rays (short-wave ultraviolet radiation) and this is where the highly effective sun filters of sebamed’s waterproof sun care products offer the best possible protection. Reapplication after 150 minutes.36 37 sebamed sun care Triple protection for the skin In the sun the skin absorbs vitamin D and reacts to UV exposure positively through the thickening of the Stratum corneum. Sweating and bathing removes filter substances and pigments from the skin. 0 Change in skin hydration Change in skin surface lipids (Maas. 2006 – unpublished study) % skin hydration 33.20 minutes prior to UV exposure. sebamed Anti Dry offers a compelte program for uniquely mild cleansing. lipids and proteins in the cells and tissue. recommended therapy supportive skin care for atopic dry skin • Highly effective sun filters absorb the harmful UVA and UVB rays • Vitamin E neutralizes free radicals to protect against premature aging and sunburn • Highly effective moisturizing complex protects the skin. scaling and which irritation.6 . For older children. require special skin care. which builds a protective film. For this reason sebamed Sun Care has a special water-proof formula. age hormones. Independent of the cause. The adequate SPF should be chosen according to the individual skin type and exposure time. However the powerful UV rays of the sun can also cause irreparable injury to the skin through damage of the DNA. preventing dehydration Water resistant sun screens: All sebamed sun care products are water-proof. sebamed Anti-Dry Regenerates dry skin. Klinik Norddeich.5 to protect the health of the skin’s acid mantle. which combine emollience with anti-inflammatory efficacy. producing sunburn. The sebamed Anti-Dry products range was evaluated in 17 patients suffering from Type II Diabetes over 2 weeks. Rules for using sun screens: Sun lotions or creams should be applied 15 . A special note: Children under 1 year of age should not be exposed to the sun. Dermatological test of the sebamed Anti-Dry product range in 20 children suffering from atopic eczema % 30 20 10 35 30 23 Change in skin barrier function Dermatologists concluded that the products are highly recommendable for dry. Dry skin is a common skin problem with symptoms of tightness. 40 30 20 10 0 Initial after 2 weeks (Schaube. 2006 – unpublished study) In-use test of sebamed Anti Dry range in diabetic patients Diabetes is associated with dry skin. All sun care products are readily absorbed by the skin and formulated with the pH value of 5. like genetic disposition for sebostasis. which strengthens its resistance to environmental influences and promotes melanin synthesis. The overall state of the skin improved during use of the products. systemic diseases like diabetes. However by prolonged water contact the sun protection is ultimately reduced. and irritated children’s skin. skin diseases like atopic eczema or psoriasis. sun allergies and increasing the risk of skin cancer. decreasing the SPF. sebamed Sun Cream SPF 28 is recommended. Dryness and itching decreased. All products are clinically and dermatologically tested. Suitable for children.
the scalp 49% Furthermore a 37% reduction of itchiness was achieved Package size: 200 ml bottle Ingredients: Aqua. Glyceryl Oleate. Methylparaben. Sodium Lauroyl Sarcosinate. Package size: 200 ml bottle Skin symptoms severity 2 1. Magnesium Sulfate. Cocamidopropyl Betaine. itching and stinging. Ethoxydiglycol. Algae extract. 1000 ml bottle wih pump Ingredients: Aqua. Dicaprylyl Ether. Phenoxyethanol. Magnesium Sulfate. Polyglyceryl-2 Dipolyhydroxystearate. The regenerative capacity of the rapeseed phytosterols concentrate effectively alleviates redness. Disodium Laureth Sulfosuccinate. (Fluhr et al. vitamin E and a moisturizing starch derivative for intensive skin care to relieve a dry skin condition. It spreads easily and penetrates immediately and completely pH 5. Hydrolyzed Soy Protein. Parfum. Coco-Glucoside. Glycerin. Cetearyl Glucoside. Glycerin. Brassica campestris Sterols. Butyrospermum parkii butter. Hydroxypropyl Oxidized Starch PGTrimonium Chloride.. Hydroxypropyl Guar Hydroxypropyltrimonium Chloride. Phenoxyethanol. lipids.5 Mild cleansing with rich emollience and moisturizing skin care complex with phytosterols. The pH value of 5. Day Defense Cream Protecting. The lotion is rapidly absorbed without leaving residue. The pH value of 5. Benzyl Alcohol. Tocopheryl Acetate. The gentle wash active complex in combination with the re-hydrating capacity of Panthenol is formulated to safeguard and conserve the skin’s moisture balance. which results in a noticeable improvement of the skin feeling. Sodium Lactate. C12-20 Alkyl Glucoside. MIPA-Laureth Sulfate. Dermatologically tested in dry skin: moisturizes during cleansing. glucose and lipids to give dry skin reliable protection against irritation and dryness through lipid erosion. Parfum. Phenoxyethanol.5 protects the skin’s natural protective acid mantle against dehydration and irritants. C14-22 Alcohol. Sodium C14-16 Olefin Sulfonate. Sodium Benzoate. Brassica campestris Sterols.5 supports the regeneration of the acid mantle. Sodium Lactate. Parfum. Octyldodecanol. 2002 – unpublished study) Hydrating Body Lotion The organic-sourced active ingredient complex of the lotion effectively nourishes the skin. Laureth-4. Disodium Cocoamphodiacetate. Dermatologically tested. Sodium Citrate. unpublished study) Hydrating Shower Balsam Dermatological in-use test of sebamed Anti Dry Dermasoft Wash Emulsion and Hydrating Body Lotion Test in 30 cancer patients undergoing chemotherapy. Parfum. Glycerin. Sodium Benzoate. Package size: 200 ml bottle.5 1 0.5 0 dryness roughness flaking tension itching stinging erythema erosions Ingredients: Arachis hypogaea oil. hydration. Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer. Butylparaben. Aqua. An improvement of the state of the skin. Simmondsia chinensis oil. Polyglyceryl-3 Diisostearate. Potato Starch Modified. Cocamide DEA. Palmitoyl Hydrolyzed Wheat Amino Acids. Propylparaben. Sodium Citrate. Phenoxyethanol. Night Intensive Cream Dermatological in-use test of sebamed Anti Dry Derma-Soft Wash Emulsion Test in 31 persons with dry skin over 3 weeks 100 90 80 70 60 Beginn 1 Woche 2 Wochen 3 Wochen Unterarm Change in skin hydration Stirn Intensive and rich skin care supports the natural regeneration processes in the skin during the night. 120 Beginn 3 Wochen (Schürer. Package size: 200 ml bottle Ingredients: Aqua. PEG-120 Methyl Glucose Dioleate. in press) . Sorbic Acid. Sodium PCA.5 enhances the skin‘s natural barrier function against dehydration and irritants Package size: 50 ml jar Ingredients: Aqua. Parfum. and soothing O/W emulsion with 1% Phytosterol concentrate. boosting hydration by 26% within a 3-week period. Magnesium Sulfate. Avocado oil. Parfum. Panthenol. Sodium Benzoate. Brassica campestris Sterols. pH 5. Glyceryl Stearate SE. Persea gratissima oil. Prunus dulcis oil. Caprylyl/ Capryl Glucoside. Improvement with 3 weeks: Reduced dryness of the hair by 47%. Brassica campestris Sterols. Hexyl Laurate. proteins and amino acids. Cetearyl Alcohol.38 39 Product range: Derma-Soft Wash Emulsion The unique ingredient composition of sebamed ANTI DRY Derma Soft Wash Emulsion is based on natural skin-related amino acids. Sodium Laureth Sulfate. Polyisobutene. Dicaprylyl Carbonate. Cera alba. Sorbitan Oleate. smoothing. smoothing and regenerating effects. Palmitoyl Hydrolyzed Wheat Amino Acids. Glycerin.5 enhances the skin‘s natural barrier function against dehydration and irritants Package size: 50 ml jar Ingredients: Aqua. baseline 1 week 2 weeks final Revitalizing Shampoo komedons papules The extra mild wash active compound gently cleanses the hair without irritating the scalp. The shower balsam provides protection against dryness and irritation for dry and sensitive skin. and barrier function as well as a decrease in skin symptoms were observed. The phytosterol concentrate supplying rich emollience combines with shea butter. Benzyl Alcohol. The active wheat germ protein and amino acid complex combined with soy portein and guar see somoothes and regenerateds the structure of the hair and relieves the dryness of the scalp. Sodium Lactate. 2. Hydrolyzed Wheat Protein.5 protects during cleansing to support a rebalancing of the scalp and hair structure. The high content (3%) of Phytosterol concentrate together with Jojoba oil and Glycerin in this water-in-oil emulsion provide pronounced soothing. Glycerin. Tocopheryl Acetate. Glyceryl Laurate. Lübeck. Xanthan Gum. The pH value of 5. 2002. Propylene Glycol. and Vitamin E. Lauryldimonium Hydroxy-propyl Hydrolyzed Wheat Protein. Hydrolyzed Wheat Protein. Sodium Benzoate. Laureth-2. Poloxamer 101. Clinical study with sebamed Anti Dry Day Defense Cream and Night Intensive Cream Test in 30 persons with dry skin over 3 weeks 150 skin lipids (arbitrary sebumeter values) 140 130 (Wolf et al. Sodium Citrate. Lauryldimonium Hydroxypropyl Hydrolyzed Wheat Protein. Ethoxydiglycol. The high skin care efficacy reduces the water and lipid loss during showering provides an excellent basis for the subsequent application of creams or lotions. Tocopheryl Acetate. Sodium Lauroyl Glutamate. algae extract.
which is natural to the body. Benzyl Alcohol.40 41 sebamed Anti-Ageing Prevention. Glyceryl Stearate SE. Diisopropyl Adipate. Before use After use A reduction according FOITS measurements of wrinkles in the depth of 0 µm. Product range: Q10 Protection Cream The visible reduction of fine lines and wrinkles within 28 days and excellent skin tolerance demonstrate the efficacy of this anti-ageing cream without vitamin A derivatives. Potassium Cetyl Phosphate. natural lipid resources of shea butter. The co-enzyme Q10.4 2. (Institute Schrader. Cetearyl Alcohol. Rapidly absorbed without oily residue to provide 24 hour protection. Parfum. Glycerin. as well as the probates as good. Sodium Citrate. The free-radical scavenger vitamin E. LIFTING EYE CREAM OPHTALMOLOGIC TEST: 33 women of which16 were contact lens wearers In-use test: twice daily for a period of 4 weeks Results: Conjunctiva tolerance and local skin tolerance was assessed by the ophtalmologist. 30 test candidates used the lotion daily for a 28 day period after cleansing. Package size: 50 ml jar Ingredients: Aqua. Argania Spinosa Kernel Oil. Sodium Hyaluronate. moisture binding phytosterols and regenerating panthenol combine in this light. activates the metabolism of energy on a cellular level. Bisabolol.75 2. Palmitoyl Tetrapeptide-7. Package size: 200 ml bottle Severity of wrinkles Anti-wrinkle effect Moisturizing effect No. Glyceryl Stearate Citrate. Hamburg 2005) Ingredients: Aqua. barley extract and shea butter improve and maintain the elasticity of the skin to counteract firmness.15 2. which activates the metabolic energy on a cellular level and the innovative botanical ingredient complex Derma Active of argan oil. Persea gratissima oil. Behenyl Alcohol. Butyrospermum parkii butter. Phenoxyethanol. Q10 Firming Body Lotion In-use test of sebamed Anti-Ageing Q10 Protection Cream on 20 women Evaluation of efficacy and tolerance Average ratings by users 16 58% validated improvement in firmness within a 3 week period in 93% of the test candidates. Tocopheryl Acetate. The pH value of 5. 28 day in-use test The skin surface profile exhibited significantly increased smoothness in FOITS measurements. an important catalyst. Sodium Citrate. Prunus dulcis oil. The valuable. Parfum. Cetearyl Glucoside. Cetearyl Glucoside. 30 test candidates used the eye cream daily for a 28 day period after cleansing. Spent Grain Wax. Benzyl Alcohol. Polyglyceryl-2 Dipolyhydroxystearate.2 1. Ubiquinone. Polyglyceryl-2 Dipolyhydroxystearate.5 supports the barrier function against dehydration and penetration by irritants and allergens. Xanthan Gum. Phenoxyethanol. Coco Glucoside. Co-enzyme Q 10 as important catalyst to activate the metabolism of oxygen in the cells. which can irritate sensitive skin. Phenoxyethanol. C12-15 Alkyl Benzoate. Munich. Its production in the skin decreases noticeably from the age of 30. The pH value of 5. Hydrogenated Polydecene. Butylene Glycol. Benzyl Alcohol. Palmitoyl Oligopeptide.15 1. Germany 2004 unpublished data) . Prunus dulcis oil. Q10 Lifting Eye Cream sebamed ANTI-AGEING Q10 Lifting Eye Cream has been formulated to reduce fine lines and wrinkles in the sensitive eye area. Sorbitol. degenerating influences. Regeneration The sebamed ANTI-AGEING skin care management system has been created to support the natural metabolic processes and receptivity of the skin to prolong its youthful vitality. of users Skin tolerance 14 12 10 8 6 4 2 0 2. Sodium Polyacrylate.75 good 2 satisfactory 3 below average 4 28 day in-use test 12 8 11 The skin surface profile exhibited significantly increased smoothness in FOITS measurements. Parfum. Dicaprylyl Carbonate. Cetearyl Alcohol. An active ingredient complex based on phytopeptides combined with mucopolysaccharides provides intensive moisture. Formulated with coenzyme Q 10. Squalane. Ubiquinone. Ubiquinone. Package size: 15 ml tube Ingredients: Aqua. Glycerin. 2003 unpublished data) (Worret.5 stabilizes the barrier function of the acid mantle to shield against noxious. Panthenol. Protection. C12-15 Alkyl Benzoate. avocado and almond oils smooth the skin. Increased hydration and moisture balance help the skin to regain and maintain its equilibrium to safeguard against premature ageing. Lauryl Glucoside. 13 Emollience Skin feeling Skin care effect poor 5 very poor 6 6 1 6 2 0 0 after 1 week 1 0 after 3 weeks excellent 1 before treatment none mild moderate severe Before use After use (Institute Schrader. Sodium Citrate. Sodium Benzoate. The anti-wrinkle effect was evaluated as good to very good. yet rich oil-in-water to compensate for existing age-induces changes and to prevent further damage to the skin structure and functions. Sodium Lactate. Sodium Carbomer. Butyrospermum parkii extract. Brassica campestris Sterols. Properties and special feature: Less wrinkles in 28 days eye area. 2003 unpublished data) (Test institute: proDerma. Butyrospermum parkii butter.
Arens-Corell. Magnesium Sulfate. Sodium Lactate. Glyceryl Stearate SE. Package size: 75 ml jar Dermatological in-use test of sebamed F+S Night Cream % decrease in skin roughness 0 -2 -4 -6 -8 Ingredients: Aqua. units) (Institute Schrader.42 43 sebamed F + S Fine + Sensitive New vitality for mature skin In the fourth decade of life the skin often develops dryness and increased sensitivity. Protects against dryness with pentylene glycol. Almond oil. Squalane. 90 skin hydration (rel. Sorbic Acid. Cetearyl Alcohol. Allantoin. Holzminden. Parfum. Phenoxyethanol. Ascorbyl Palmitate. Lübeck.3 30 test persons used sebamed F+S lotion twice daily for 3 weeks on one forearm. Dermatological test of sebamed F+S Night Cream in 20 test persons applying the cream daily for 2 weeks. Jojoba oil and shea butter smooth the skin and prevent it from drying out. Its pH value of 5. skin-related squalane. Tocopheryl Acetate. unpublished data) cheek 85 Lotion 86. Sorbitol. Cera alba. M. Sodium Laureth-6 Carboxylate. Propylene Glycol Dicaprylate/Dicaprate. phytosterole and ceramide 3 make the skin smooth.4 76. -3. Dermatologically proven to improve the moisture of dry skin areas. Germany 1997. Package size: 200 ml. Vitamin E protects against premature aging caused by free radicals. Hexyldecanol. Simmondsia chinensis. Sodium Citrate. unpublished data) Night Cream A water-in-oil emulsion containing 38% lipids for intensive protection and moisturizing action. 30 test persons used sebamed F+S Day Cream daily for 2 weeks. Simmondsia chinensis oil.8 F+S Night cream Competitor product Ingredients: Aqua. H. Glycerin.5 30 test persons with dry skin washed their face and body twice daily with sebamed F+S Dry Skin Wash for three weeks. Disodium Laureth Sulfosuccinate. Environmental stress factors like UV radiation. sensitive and stressed skin. Panthenol. unpublished data) (J.2 84. shea butter. Package size: 200 ml bottle Dermatological in-use test of sebamed F+S Lotion 14 10 6 2 -2 % change in skin hydration compared with initial value 70 65 68 64 with sebamed F+S lotion without lotion start after 1 week after 2 week after 3 week 60 start 1 week 2 weeks weeks of use 3 weeks -6 (Weltzel. Germany 1996. skin-related lecithin and squalane make the skin supple and protect it against drying. Product range: Dry Skin Wash This mild emulsion gently cleanses the skin without removing protecting lipids and moisture or causing irritation. Vitamin E protects against free radicals and panthenol supports the regeneration of the skin. 15 10 5 0 start after 2 weeks (Institute Schrader. Wolf. Polyglyceryl-3 Methylglucose Distearate. Xanthan Gum. Butyrospermum parkii. Plant lipids: jojoba oil.5 -7. Sodium Lactate. Panthenol helps the skin regenerate. Skin care with sebamed F+S gives intensive protection and care to dry. Fine wrinkles are smoothed and skin elasticity is maintained. shea butter. air pollution and low air humidity accelerate the inherent aging processes. Wolff. sebamed F+S has been developed especially to meet the particular needs of mature skin. Hydrolyzed Silk. Panthenol. Benzyl Alcohol.5 and the selected skin care ingredients support the natural barrier functions against environmental stress factors and decelerate the aging processes. Behenyl Alcohol.9 80 forearm 74.4 78. Hexyldecyl Laurate. C12-15 Alkyl Benzoate. PEG-120 Methyl Glucose Dioleate. Package size: 75 ml jar Dermatological in-use test of sebamed F+S Day Cream % increase in hydration as compared to initial value 20 Ingredients: Aqua. Benzyl Alcohol. H. Glyceryl Oleate. sebamed F+S Dry Skin Wash: ameliorates skin hydration with mild cleansing agents and the pH 5. Parfum. while the other remained untreated. 400 ml bottle with pump Ingredients: Aqua. Absorbs easily and does not leave a greasy film. Sodium Citrate. 75 An oil-in-water emulsion containing 21% lipids increases skin smoothness and elasticity. Holzminden. Phenoxyethanol. Parfum. T&E Dermatologie 1998) .6 86. Magnesium Sulfate. Phenoxyethanol. Day Cream Moisturizing oil-in-water emulsion with a 24% lipid content. Squalane. Butyrospermum parkii. Decyl Glucoside. Caprylic/Capric Triglyceride. Lecithin. Parfum. Pentylene Glycol. cigarette smoke. Tocopheryl Acetate. giving it the right care and protection every day. Ceramide 3. Polyglyceryl-2 Dipolyhydroxystearate. Prunus dulcis.Welzel. Sodium Carbomer. Brassica campestris Sterols. Sorbitol. Cetearyl Glucoside. Germany 1996. Butyrospermum parkii butter.
Daily use supports the skin to activate its natural moisturizing system.44 45 Visio Protection and moisture for the sensitive facial skin Facial skin is thinner and more permeable than the skin on other parts of the body. Package size: 50 ml jar Ingredients: Aqua. Hydrolyzed Silk. Holzminden. Potassium Sorbate. Mild cleansing agents remove dirt and make-up gently and thoroughly. Sodium Lactate. Glycerin. skin alterations in the face are clearly visible. Decyl Oleate. Cetearyl Alcohol. To be applied with the help of tissue or cotton pad. yeast protein and active moisture retaining ingredients. Units) 40 30 20 10 0 0 5 10 20 30 40 60 90 120 180 240 minutes (Institute For Applied Skin Physiology. Calendula officinalis flower extract. Allantoin. Propylene Glycol Dicaprylate/Dicaprate. Methyl Glucose Sesquistearate. Hamamelis virginiana bark/ leaf/ twig extract. Holzminden. Package size: 200 ml bottle Increase in Skin Hydration by sebamed VISIO Gentle Toner Ingredients: Aqua. Methylparaben. To be used on wet or dry skin and removed with the help of tissue or cotton pad. or rinsed off with water. Visio Hydro Gel distinguishes itself through its high dermatological tolerance equally on very dry atopic skin and even oily skin requiring moisture to regain balance. Propylene Glycol. Sodium Chondroitin Sulfate. and penetrate easily through their skin-related molecular structure. Butylene Glycol. cucumber extract and hydrolyzed silk are absorbed easily by the skin. Sodium Hyaluronate. Especially formulated for the protective care of dry and sensitive skin. Cetyl Palmitate. which enrich the moisture balance of the skin during cleansing. Ethylhexyl Methoxycinnamate. Use mornings and evenings. Glycerin. refreshing the complexion. Propylene Glycol. Potassium Sorbate. Sodium Benzoate. it requires special care. These active ingredient depots are released slowly. Phenoxyethanol. Its plant-based moisturizing complex Biophytex® contains marigold extract. Germany 1995. pollutants. VISIO Cleansing Milk 25 20 15 10 5 0 0 5 10 20 30 40 60 90 120 180 240 minutes moisturizing lotion sebamed VISIO Hydro Gel decreased skin roughness and increased skin hydration during 2 weeks with twice daily application in 20 text persons after repeated (twice daily) skin dehydration by washing with Sodium Lauryl Sulfate. Phenoxyethanol. Glycerin. Propylparaben. botanical ceramide and borage oil increase the humectant capacity of the skin. Squalane. Propylene Glycol. Cucumis sativus fruit extract. Panthenol. PPG-2 Myristyl Ether Propionate. Change in skin hydration (rel. Sodium Hyaluronate. unpublished data) (Institute Schrader. sebamed VISIO Skin Toner increased skin hydration in 20 test persons markedly. Panthenol. Germany 1995. Holzminden. Laureth-23. Atelocollagen. CI 42090. 5 4 3 2 1 0 -1 % change in skin roughness 10 8 % change in skin hydration 4. Additionally. a 20% increase in hydration was still detectable. Caramel. Methylparaben. Glycine soja oil. Borago officinalis seed oil. Sodium Citrate. Allantoin. Ammonium glycyrrhizate. Paraffinum liquidum.42 -2 -4 -6 -8 -10 (Institute Schrader. Sodium Carbomer. protection and skin tolerance. Sodium Citrate. Pentylene Glycol. Sodium Benzoate. Sorbitol.21 untreated 6 4 2 0 8. Glycerin. Saccharide Isomerate. unpublished data) .31 -2 -3 -4 -5 VISIO Hydro Gel -4. PEG-20 Methyl Glucose Sesquistearate. Allantoin makes the skin smooth and supple. Furthermore. The sophisticated scientific formulation with allantoin. Sodium Carbomer. Aloe barbadensis leaf gel. Parfum. Sorbic Acid. Centella asiatica extract. Farnesol. Ethylparaben. Glyceryl Stearate. Especially developed without alcohol for sensitive skins of all types. Panthenol. Polysorbate 20. Parfum. Change in skin hydration (rel. Germany 1995. Hydro Gel Increase in Skin Hydration by sebamed VISIO Cleansing Milk sebamed VISIO Cleansing Milk increased skin hydration in 20 test persons like a moisturizing lotion. Hydrolyzed Yeast Protein. Visio Gentle Cleansing Milk combines the benefits of a cleansing emulsion with a moisturizing lotion. Menthol. the face is much more exposed to noxious environmental factors like UV radiation. Sodium Cetearyl Sulfate. panthenol and the naturally moisturizing hyluronic acid activates the skin’s hydrolipid system and promotes cell regeneration. unpublished data) Day Cream Product range: Gentle Cleansing Milk Moisturizing cleansing milk to support the skin’s own acid mantle. Sorbic Acid. Aesculus hippocastanum extract. Sodium Cetearyl Sulfate. Thus. Parfum. Ruscus aculeatus root extract. Allantoin. Sodium Citrate. C12-15 Alkyl Benzoate. Dimethicone. Package size: 50 ml jar In-use test of sebamed Visio Hydrogel Ingredients: Aqua. Even after 4 hours. Combined with the vitasqualane complex. and low air humidity. The moisturizing properties of witch hazel. and therefore of higher concern to an affected person. Tocopheryl Acetate. making it soft and supple. CI 77289. Visio Active Hydro Gel with its micro thalaspheres of marine mucopolysaccharides. Sodium Carbomer. Chlorphenesin. The result is an immediate 41% increase in moisture content. Cetearyl Alcohol. Package size: 200 ml bottle Ingredients: Aqua. Caprylic/Capric Triglyceride. Units) 30 The humectant potential of the hydro gel is beneficial for all skin types. PEG-40 Stearate. Lecithin. the skin is assured optimal hydration. Gentle Facial Toner Tones and revitalizes the skin after cleansing.8 VISIO Hydro Gel untreated -8. Phenoxyethanol.
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