You are on page 1of 2

Endocan / ESM-1

Your solution for the analysis of vascular remodeling


Monoclona Antibody MEP08

The monoclonal antibody against human endocan / ESM-1 called MEP081 (LIA-0901) developed by Lunginnov can analyze the activation of the endothelium by immunohistochemistry

Background
Endocan also called endothelial cell specific molecule 1 or ESM-1 is a biomarker of endothelial dysfunction (Sarrazin et al. 2010). This proteoglycan of 50 kDa is overexpressed by vessels in lung, liver, brain and kidney cancers (Grigoriu et al. 2006 ; Maurage et al. 2009 ; Leroy et al. 2010 ; Sarrazin et al. 2010). Recently endocan / ESM-1 was identified as a biomarker of tip cells , endothelial cells involved in tumor angiogenesis (Sarrazin et al. 2010). The tissue expression of endocan is correlated with the tissue expression of VEGF (Huang et al. 2009). Anti-angiogenic treatment of endothelial cells decrease the expression of endocan / ESM-1 induces by theVascular Endothelial Growth Factor (Grigoriu et al. 2006 ; Leroy et al. 2010). By its ability to discriminate tumor vessels of normal vessels, the antibody MEP08 (LIA-0901) allows an analysis of vascular remodeling and represents a pertinent tool to evaluate the angiogenesis.

Main features
Monoclonal antibody (mouse) Recommanded for immunohistochemistry (paraffin and frozen sections) Specific of the N-terminus of human endocan Easy to use / do not required any enzymatic pre-treatment Can be use with automatized procedures Stored at 4C / -20C

References
Bechard et al. (2000) J. Vasc. Res. 37:417-425 Grigoriu et al. (2006) Clin. Cancer Res. 12:4575-4582 Huang et al. (2009) Dig. Dis. Sci. 54:389-394 Leroy et al. (2010) Histopathology 56:180-187 Maurage et al. (2009) Exp. Neurol. 68:836-844 Sarrazin et al. (2010) J. Cancer. Sci. Ther. 2:47-52
1

This product is for research use only and is not intended for diagnostic or therapeutic use

Lunginnov Campus de lInstitut Pasteur de Lille 1 rue du Pr Calmette, 59000 LILLE, France. Tel : (33) 320 877 211 / Fax : (33) 320 877 884 E mail : contact@lunginnov.com www.lunginnov.com