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.somsinacem sortuo rop salulc sassed oav -ita ad aicnqesnoc sam ,EgI ed aneserp ad aicnrroced on sotnemacidem moc saduga seaer sad etrap roiam a euq odatlasser res eved ,aivadoT .aixalifana e amedeoig -na/aircitru omoc ,sacisslc saduga sacigrla seaer sad acipt oautis atsE .sasovren seanimret e saludnlg ,asil arutalucsum ,sosav me edadivita moc saicntsbus ed oarebil etneqesnoc e salulc satsed oavita a an -imreted sotictsam ed anarbmem sodaxif EgI soprocitna moc )arodagerrac anetorp odaicossa ocamrf( onegtna ed oagil A .)sonetpah( sotilbatem sues uo socamrf arap EgI soprocitna ed oamrof alep erroco )ocitlifana( I opit O .5)1 ordauq( acigrla edadilibisnesrepih ed seaer sa redneerpmoc rohlem arap sotnemadnuf so recelebatse levssop sbmooC e lleG ed oacifissalc ad svartA
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.)enumi-on edadilibisnesrepih rop seaer ,adnia ,uo sacig -rla-oduesp seaer omoc sadaziretcarac setna( acigrl -a-on edadilibisnesrepih rop seaer omoc sadaredis -noc res meved seaer satse ,OAW ad atsoporp alep ,mis -sA .ociglonumi omsinacem rop sadacovorp os on euq zev amu airogetac atsen ardauqne es on sotnemacidem a seaer sad etrap roiam A .EgI rop adaidem agord a aigrela ,olpmexe rop ,oaer ad omsinacem ed opit o es-odnatnecserca ,sagord a aigrela ed sadamahc os acig -lonumi oaer ed aicnqesnoc me megrus euq sagord a seaeR .)ralulec( salulc rop uo )laromuh( soprocitna rop adaidem res odnedop ,ociglonumi omsinacem rop adacov -orp edadilibisnesrepih a aigrelA .adizudorper res edop euq e odinifed olumtse rop adaicini oaer reuqlauq edad -ilibisnesrepih ed es-animoned ,atsoporp atseN .sacigrla
snoitcaer gurd esrevda ,tset niks ,ygrella gurD 231-521:)3(82 ;5002 .lotaponumi .grela .sarb .veR .sisongaid reporp a ekam ylefas nac tsigrella eht taht os ylfeirb desserdda era sesongaid lacinilc gnikam rof sdohtem gnitsixe ehT .snoitcaer gurd cigrella fo snoitatneserp lacinilc nommoc tsom eht dna smsinahcem eht sweiver repap sihT .noitagitsevni lufsseccus a fo skramllah eht era noitcaer eht fo yrotsih suolucitem a dna noitanimaxe lacisyhp deliated A .naicinilc eht fo lliks eht no sediser noitaulave lacidem eht fo emoctuo eht oS .sisongaid lasuac a ekam ot sdohtem ortiv ni ro oviv ni evitceffe on era ereht sesac eht fo tsom nI .ylsuoenatlumis seussit ynam osla ro niks eht ylelos tceffa yam snoitcaer hcuS .seciffo s'tsigrella ta devresbo yltneuqerf era dna sgurd ot snoitcaer esrevda eht fo %52 rof tnuocca snoitcaer cigrella-oduesp dna cigrellA

seidnoc sad arutalcnemon an searetla samugla etnem -etnecer sporp )OAW( noitazinagrO ygrellA dlroW A .3sotnemacidem a sasrevda seaer sad latot od %52 etnemadamixorpa rop mednopser edadilibis -nesrepih ed seaer sA .)sacigrla-oduesp e sacigrla se -aer( edadilibisnesrepih ed seaer san e aisarcnissoidi ,aic -nrelotni an omoc ,laudividni edadilibitecsus sadaicossa otse sievsiverpmi seaer sA .cte ,lanimodba otrofnocsed ,ailafec ,aicnlonos :omoc siat ,seacidem sad snumoc siam siaretaloc sotiefe so odnaziretcarac ,setneqerf siam sa os sievsiverp seaeR .2agord ad aciglocamraf edad -ivita sadanoicaler on ,snumocni sievsiverpmi seaer ,uo ,-oudvidni reuqlauq me rerroco medop euq ,snumoc - sievsiverp omoc sadacifissalc res medop sagord a se -aeR .1"saneod ed otnematart uo ocitsngaid ,oneverp arap sadagerpme etnemlautibah sesod san ocituparet on otiefe reuqlauq otnemacidem a asrevda oaeR" :zid )SMO( edaS ad laidnuM oazinagrO ad oinifed A .etneicap od acinlc airtsih a ocitsngaid on etnatropmi siam otcepsa o seautis satsed reuqlauq araP .sotnemacidem a seazilibisnes siautneve rasiuq -sep a sodalumitse e seatsefinam mes sosoisna soudv -idni ,sezev samugla e odassap on oaer ed airtsih moc setneicap ,etnecer oidsipe receralcse arap :oirtlusnoc me etneicap od oatneserpa ed samrof sairv metsixE .sodan -retni setneicap ertne lareg me oalupop an aicnlaverp a ecehnocsed es ,otnemom oN .seralatipsoh seanretni sad %6 e %2 ertne sotnemacidem a seaer ed aicnlaverp a es-amitsE .acinlC aigrelA ed airid acitrp an setneq -erf saicnrroco os sotnemacidem a sasrevda seaeR
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sagord a sasrevda seaer ,soentuc setset ,sotnemacidem a aigrelA 231-521:)3(82 ;5002 .lotaponumi .grela .sarb .veR .oirtlusnoc on oailava ed opit etse anaruges moc rizud -noc a atsigrela a ratneiro odnarucorp ,atnicus amrof ed sadad -roba os sacitsngaid satudnoc sA .sotnemacidem a seaer sad acinlc oatneserpa ed samrof siapicnirp sad e somsinac -em sod osiver amu somezaf ogitra etseN .acitsngaid oail -ava an aicntropmi lativ ed os sosoicunim semaxe e acinlc airtsiH .rodagitsevni od edadilibah e oacided ad aicntrop -mi a autneca es ,amrof atseD .seaer sad airoiam ad oac -ifitnedi an setneicife soentuc setset uo siairotarobal sodotm metsixe oN .sodicet sosrevid etnemaenatlumis ratefa mbmat uo elep a etnemavisulcxe retemoca medop seaer sA .acinilc aigrela ed soirtalubma son aicnqerf moc sadavresbo os e sotnemacidem a sasrevda seaer sad %52 etnemadamix -orpa a mednopserroc sacigrla-oduesp e sacigrla seaeR

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.)sesel sad osn et xe a e mrofn oc( OV sediretsocitroc ,socinmatsih-itna ,sodiuql oisoper ,acipt o acideM .acipt o acideM acipt oacidem ,)?( ocinmatsih-itnA .cte ,atsinoga -2a teb ,ediretsocitroc ,ocinmatsih-itna ,anila nerdA socinmatsih-itnA

adidnufnoc res edoP .agord ad osnepsus a spa ,sezev satium ,e oacidem ad osu ed said snugla spa egrus o -atsefinam atsE .siariv sametnaxe soa etnahlemes otcep -sa O .ecaf a odnapuop sorbmem e ocnort on megrus euq sasotametire salucm saneuqep rop adaziretcarac ralup -apolucam opure A .sotnemacidem a oaer ed setneq -erf siam samrof sad amu emrofilibrom opurE setnavisluvnocitna ,HNIA safluS HNIA ,anilcica rteT socitibitnA seralu csum se tnaxaler ,socitibitnA AC E ad serodibinI ,HNIA socitibitna ,HNIA ,SAA acixt acimrdipe esilr cen e n osnhoJ -sn evetS ed emordnS ,emrofitlu m a metirE oxif a metirE emrofilibrom op urE aixalifanA amedeoignA amedeoign a e aircitrU

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.8,7adacifiton on seaer sad etrap ednarg euq otsiv adanimreted res ed levssopmi etnemacitarp oalupop an sasrevda seaer sad laer aicndicni A .7sona 61 ed seroiam setneicap me seazilat -ipsoh sad latot od %6-5 rop levsnopser sotnemacidem a asrevda oaer a euq uonimreted socintirb siatipsoh siod me etnecer otnematnaveL .6sodazilatipsoh setneicap me sevarg sasrevda seaer ed %1,2 ed aicndicni a uoc -ifirev AUE son sovitcepsorp sodutse 93 ed esilnateM .set -neqerf otium os sotnemacidem a sasrevda seaeR

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oxif ra tn emgip a metire ,saigrelaotof ,se ralupapoluca m s epu re ,ota tn oc ed am ezcE saitapolu csav ,setirfenoluremolg ,aircit ru ,e rbe f ,oros od a neoD setino m ue np ,sainepotic ,setirfeN omsa pseoc norb ,a medeoigna ,aircitru ,aixalifanA

-atem od oaretla )2 ;).cte ,anifrom ,anedoc( sotictsam ed aterid oavita )1 :omoc ,somsinacem soirv ed sv -arta rerroco medop seaer sassE .EgI rop sadaidem se -aer sa etnemacinilc alumis )senumi-on uo( sacigrla-on edadilibisnesrepih ed seaer sad etrap ednarG .sanicotic e T soticfnil ed oapicitrap sodaicossa ratse mecerap semrofilibrom sametnaxe sO .acigrla otatnoc ed etitamred a ocisslc olpmexE .sievlos sotudorp sues e T soticfnil rop odaidem )aidrat edadilibisnesrepih( VI opit O .aiglartra e erbef omoc ,sacimtsis seatsefinam ed adahnapmoca ,onairacitru ordauq rop adaziretcarac ,oros od aneod a oautis atsed olpmexE .laudicet osel odnacovorp ,seraelc -unonom e seraelcunofromilop ed oavita e oarta anim -reted otnemelpmoc od ametsis od oavita etneqesbus A .oprocitna e onegtna ertne sodamrof soxelpmoc ed laud -icet oisoped e oamrof alep erroco euq oaer a acifit -nedi sbmooC e lleG ed )senumi soxelpmoc( III opit O .edadilibisnesrepih ed omsinacem etse a sadaicossa sacinlc seatsefinam sa os ainepoticobmort e sainepocuel ,saim -enA .laudicet e ralulec onuf ad adrep a e ovla alulc ad oiurtsed a animreted omsinacem etsed oavita A .agord alep sadaretla ralulec anarbmem ad sacingitna saicnq -es arap uo salulc ed anarbmem an sodivrosda sotnem -garf sues uo sagord arap socifcepse MgI uo GgI soproc -itna ed oa alep adaziretcarac )ocixtotic( II opit O
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ovon a etneicap o ropxe eved es oN .avitinifed amrof ed sadative res meved sacinlc seairav saus uo emrofitlum ametire ed sordauq me sadivlovne otse euq sagorD .seralucsum setnaxaler e anilic -inep ed oecxe moc ,71sodacilpa res medop on soentuc setset so ralucelom osep oxiab ed saicntsbus araP .61olp -mexe rop ,samizne e soinmroh omoc ,ralucelom osep otla ed aicntsbus onegrla o odnauq levssop etnemos otsI .EgI soprocitna ed aneserp ad oacifitnedi arap o -acidni ret medop ataidemi arutiel ed soentuc setset sO acifcepse acirs EgI e soentuc setseT .saros -simorp mecerap 51c302DC e 36DC saluclom sa omoc ,sol -ifsab ed oavita ed oanimreted a arap siatnemirepxe adnia sacincT .esatpirt ed levn od oanimreted ad sv -arta sotictsam ed oavita a railava arap )acigrla esirc a spa aroh amu ta( oros rateloc levssop aduga esaf aN .9etnemasoicunim adanimaxe res eved elep a e snumoc os saentuc seseL .osodadiuc res eved ocisf emaxe O .41sotnem -acidem a aigrela ed oagitsevni an ailav ednarg ed res edop odazinordap oirnoitseuq mu reT .oailava ad aicc -ife a ecerovaf oagitsevni ed anitor amu recelebatsE .emrof -itlum ametire e oxif ametire ,aircitru ,olpmexe rop omoc ,sotnemacidem a oaer ed savitsegus otium os seatsef -inam satreC .sortuo ertne ,sagord ed omusnoc ed sotibh ,sotnemacidem a saivrp seaer omoc setnatropmi sodad recenrof edop etneicap od assergerp acinlc airtsih A .etnaedacnesed etnega o racifitnedi ed ecnahc roiam etsixe acinlc oatsef -inam ed otnemigrus o e agord adanimreted ed otsegni a ertne laropmet oaler recelebatse levssop odnauQ .31 ,01 ,9.cte ,saitapoemoh ,socipretotif ,sanimativ ,soirt -amalfniitna ,socisglana omoc ,ocidropse osu ed sagord sad mla ,.cte ,socitloisna ,setnavisluvnocitna ,setnaimec -ilgopih ,sovisnetrepih-itna omoc ,ountnoc osu ed sagord evisulcni ,ocinlc ordauq od otnemigrus od setna adazilitu oacidem a adot ramrofni eved etneicap O .sodahlated meb res meved oulove aus e laicini acinlc oatsefin -am ad opit o ,oidsipe od oicini od sacitsretcaraC .acinlc airtsih a oagitsevni an etnatropmi siam otcepsa O .edadilibisnesrepih ed o -aer amugla ratneserpa a riv ed setna sezev sasrevid oac -idem ad osu zaf aossep a ,otnatne on ,lareg odom eD .o -acidem a moc otatnoc oriemirp on rigrus odnedop ,aivrp oazilibisnes megixe on ,ociglonumi omsinacem rop adacovorp on sotnemacidem a seaer sad etrap ednarg omoC .rodasuac otnemacidem od osnepsus a spa said socuop erroco ocinlc ordauq od ouloser a ,e seralimis sar -uturtse moc socamrf ertne adazurc oaer mumoc ;oc -ituparet otiefe rizudni arap sairssecen sa euq seronem sesod moc rerroco edop oaer a ;)agord a moc otatnoc oriemirp on erroco on oaer a( oazilibisnes a arap oirssecen oudni ed odorep mu etsixE .sacigrla se -aer s serailucep os sotcepsa snuglA .31 ,9etneicap olep sodazilitu sotnemacidem ed opit o e ocinlc ordauq o es-od -naredisnoc ,adimuserp aigoloite a sosac sesseN .lasuac etnega o racifitnedi licfid sezev satiuM .sadalanissa am -ica sa omoc ,savitsegus sacinlc seatsefinam a etnerf ad -atnavel res eved asotnemacidem aigrela ed esetpih A

ocitsngaid e oailavA

.acigrlaitna oacidem e agord ad os -nepsus etnemadipar mednopser mrop ,sasnetni otium res medop seaer sA .lanretse-arpus oiger e som ,ecaf a omoc los oa satsopxe saer etnemos atefa euq asohlob uo emrofiracitru opure ,amezce ,ametire omoc egrus o -autis atsE .ralos oisopxe ad etnedneped aentuc oaer rizudni medop sagord samuglA .edadilibisnessotoF -

.lairetra osserp ad adeuq ad e acirfirep oatalidosav ad aicnqesnoc me aicnicsnoc ad adrep e seretcnfse ed elortnoc ed adrep etsixe edadivarg roiam ed sordauq soN .sotimv e saesun ,sianimodba sac -ilc matneserpa setneicap snuglA .rerroco medop aicnlib -is omoc missa egniral ed amede rop raripser arap edadluc -ifiD .setneicap sod %09 ed acrec me setneserp seatsef -inam os amedeoigna e aircitrU .oidsipe od edadivarg ed laicnetop o roiam ,oaer a ecocerp siam otnauQ .etna -edacnesed etnega o moc otatnoc o spa sotunim socuop asserpxe es ocinlc ordauq O .EgI rop adaidem oazilibis -nes ed aicnsua an rerroco uo EgI soprocitna ed oamrof moc ariedadrev acigrla oazilibisnes ratneserper edop acitlifana oaer A .seralucsavoidrac e sianitsetnirtsag ,sairtaripser ,saentuc seatsefinam ed otpurba otnem -igrus o animreted sotictsam ed soirtamalfni serodaidem ed aicam oarebil A .etnemaenatlumis sametsis e sog -r soirv ratefa rop ,mbmat e adarepseni e adipr o -alatsni ed res rop ,evarg acinlc oidnoc aixalifanA .ociglotap -onumi omsinacem omsem o moc edadisnetni ed setnairav omoc sodaredisnoc res medop sordauq setsE .ocitsngorp o avarga euq o ,lareg odatse od otnemitemorpmoc e sasoc -um ed otnemivlovne h ,sasnetxe siam sahlob ed oam -rof e ovla me saentuc sesel sad mla ,oidnoc asseN .nosnhoJ-snevetS ed emordnS a omoc osnetxe roiam ed ordauq arap oulove ed edadilibissop a etsixE .oacidem ad osnepsus a spa sanames saud ta ,acirtmis amrof ed ,etnemlaudarg megrus sesel sA .salucsev moc sezev samugla ,sasotametire sadrob sa e oralc ortnec o moc ,ov -la mu odnecerap sadacitru sacalp rop odaziretcarac em -rofitlum ametire O .rojam emrofitlum ametire e ronim em -rofitlum ametire :sadaredisnoc os samrof sauD .sotnem -acidem a edadilibisnesrepih ed saentuc seaer sa ertne edadivarg ed laicnetop roiam ed sordauq so meutitsnoc )lleyL ed aneod( acixt acimrdipe esilrcen e nos -nhoJ-snevetS ed emordnS ,emrofitlum ametirE .).cte ,natrasol( II opit ACE ad serodibini solep adacovorp res edop mbmat oaer atsE .sodarelot meb osu ed sodorep sognol spa omsem ,amedeoigna ed sesirc rasuac medop ).cte ,lirpotpac ,lirpalane :.xe .p( ACE ad ser -odibini sovisnetrepih-itna so euq uoziretcarac es mbmat adacd amitl aN .HNIA e socisglana ed omusnoc o erb -os otnemiceralcse o raticsus eved laibal uo larbeplap am -ede ed soidsipe ed ossecus a uo odalosi amedeoigna ed aicnrroco a ,sagord a seaer ed otxetnoc oN .aircitru ed sosac so ahnapmoca ,aicnqerf moc ,amedeoignA .oidnoc assed snumoc setnega os mbmat mirpotemirt-lozaxotemaflus oaicossa a e socitibitnA .oiem osson me aircitru ed sesirc ed siasuac setnega siapicnirp so os HNIA e socisg -lanA .)acigrla-oduesp oaer( acigrla-on edadilibisnes -repih rop omoc ,agord a arap EgI soprocitna ed aneserp alep otnat rigrus edop aircitrU .sotnemacidem a oaer rasiuqsep someved erpmes aircitru ed saduga sesirc saN .siatineg sogr e soibl ,sarbeplp omoc ,selom setrap ed amede olep odaziretcarac ,amedeoigna ed adahnapmoca aircitru a sezev satiuM .saroh sacuop a sotunim me odnec -erapased setnecsenave os sadacitru sacalp sa ,soduga sordauq soN .on uo etnemaenatlumis ,siacol soirv me od -nigrus ,sasonigirurp ,seralugerri sodrob moc ,sadaicamede sacalp ed oamrof alep adaziretcarac .sagord a oaer ed snumoc siam seatneserpa sad amu aircitrU .oxif ratnemgip ametire ed serodasuac setneqerf os HNIA sO .sesel savon ed otnemigrus o mes uo moc seroiretna sesel sad oavitaer arroco agord a moc otatnoc ovon adac me euq oidnoc assed acitsr -etcarac .said snugla spa mecerapased e oremn oneuq -ep me uo sadalosi megrus sacalp satsE .adahnatsaca od -nanrot es iulove euq aecloiv-otametire opure ed otnem -icerapa olep odaziretcarac oxif ratnemgip ametirE sot ne macidem a aigrelA

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-ilicineplizneb ,soirdnuces uo( seronem setnanimreted e )liolicinep opurg ,siapicnirp uo( seroiam setnanimreted sod -amahc sotilbatem ed sopurg siod anigiro anilicinep A anilicineP

siaicepse seautiS
.olpmexe rop ,sasoreno siam seacidem ed oazilitu arap sosruc -er mes e airteuqalp oagerga ad searetla moc setne -icap me SAA ,socitdia setneicap me miportemirt-lozaxot -emaflus :omoc ,oazilibisnessed arap oacidni ret med -op mbmat sotnemacidem sortuO .22,71laretnerap uo laro aiv rop oacilpa arap sodatpada otse euq anilicinep o -azilibisnessed a arap sodazinordap solocotorp metsixE .sacituparet sepo sartuo mes sevarg secefni omoc ,samertxe seautis me acifitsuj es etnemos otnemidecorp etsE .otnematart o arap adacidni anelp esod a rignita ta levsnes etnemad -icehnocer etneicap me otnemacidem ed setnecserc sesod ed avitadarg oudortni an etsisnoc oazilibisnessed A oazilibisnesseD .otnem -idecorp o etnarud etneicap od siativ sianis so odnarotinom e edadilibisnesrepih ed avitsegus acinilc oatsefinam reuq -lauq ed otnemigrus odnailava ,sadalortnoc res meved o -udortnier ed savorp sA .12 ,02siacol savitatirri seaer racov -orp mes sadacilpa res medop euq sotnemacidem ed sedad -itnauq sa maraziretcarac la te alahcurG etnemetneceR .91-71etneicap od socsir so odniunimid osac o receralcse metimrep euq sadaz -inordap satudnoc metsixE .siacol socistsena soa seaer ed oailava an acinct atsed oacilpa ad mumoc siam olpmexe O .sacigrla-oduesp seaer san , otsi ,sotnem -acidem a enumi-on edadilibisnesrepih ed oagitsevni an oacidni ret edop otnemacidem ed oudortnier A oudortnier ed avorP .anilicinep ed siapicnirp setnanimreted so arap acifcepse EgI ed asiuq -sep a levnopsid ,etnemlaicremoC .3TSAR o omoc ,ortiv ni sacinct san racilpa arap lairetam retbo levssopmi sagord sad ovitaer otnemgarf o ecehnocsed es ,lareg odom ed ,omoC .oaer avon ed ocsir a etneicap od oisopxe a ossi moc odnative ,ortiv ni odazilaer res aireved sotnem -acidem a aigrela ed oagitsevni arap laedi odotm O .sociglotamred sord -auq setsed rodasuac etnemlevissop ocamrf moc otatnoc
5 0 02 ,3 N ,82 .loV .lota ponumi .grela .sa rb .veR

.)4 ordauq( adauqeda amrof ed ol-ilava levssop rof on es ocimtcal-ateb on ocitibitna rasu etnedurp siam ,anilicinep oaer ed etnecnivnoc airtsih ahnet euq e ocitibitna ed osu ed edadissecen moc etneicap a etnerF .sevarg siam sordauq soa sotiejus setneicap racifitnedi metimrep on , otsi ,seroiam setnanimreted art -noc soprocitna ed aneserp a maziretcarac anilicinep arap ortiv ni setset sO .)3 ordauq( zacife ovitiderp rolav met on )TSAR( ortiv ni etset O .31,3otla otium ovitagen etset ed ovitiderp rolav O .EgI rop adaidem oazilibisnes ed aicns -ua , otsi ,otsopo o acidni ovitagen oentuc etset O .agord a moc otatnoc me rartne es ataidemi acigrla oaer revlov -nesed edop ,otnatrop ,e anilicinep a arap EgI soprocitna atneserpa etneicap o euq acidni ovitisop oentuc etset O .81,71,3seronem setnanimret -ed ed sadacifirup searaperp sad edadilibisnes amsem a atneserpa on oentuc etset arap G anilicinep ed oazilitu A .etnemetnecer adulid anilatsirc G anilicineP moc oent -uc etset o mazinocerp serotua snugla ,setnegaer setse rar -aperp ed edadilibissopmi aN .anilicinep aigrela ragitsev -ni a euqided es euq lacol adac me sadaraperp res meved satsE .sairdnuces uo seronem setnanimreted saluclom sa odnetnoc etnegaer etnemlaicremoc levnopsid oN .sadareleca e sanairacitru seaer sa rineverp etimrep LPP moc oentuc etset O .)LPP ,anisililop-liolicinep( acidtpepilop aiedac amu a odagerga liolicinep -lizneb opurg o etnegaer omoc masu seroiam setnanimret -ed moc soentuc setset sO .oazilibisnes rizudni medop siaretal saiedac sa ocimtcal-ateb lena od mla euq mereg -us setnecer sodutsE .)seronem setnanimreted ed arutsim uo G anilicinep( seronem setnanimreted e )liolicineplizneb( seroiam setnanimreted saluclom sa es-odnazilitu soentuc setset ed svarta adailava res edop anilicinep a aigrelA .81saicntsnuc -ric satsen setrom sad %57 rop levsnopser odnes AUE son aixalifana ed mumoc siam asuac a anilicinep a ,arar ed rasepA .anilicinep ed seacilpa 000.01 adac arap aix -alifana ed sosac 2,1 ed aicnrroco a macidni sotnematnav -eL .senumi somsinacem sortuo rop uo EgI rop sodaidem socigrla sordauq ed oudni sodaicossa socamrf ed op -urg lapicnirp o meutitsnoc sortuo e socimtcalonom ,san -iropsolafec ,anilicixoma sodavired sues e anilicinep A .81,71,3seronem setnanimreted saluclom sa arap EgI ed oamrof alep adanimreted ,acitlifana ,ataidemi oaer A .seroiam setnanimreted saluclom s oazilibisnes rop sadacovorp os sadareleca e sanairacitru seaer sA .)an
sot nem acide m a aigrelA

821

-itaer A .oiem osson me amedeoigna e aircitru ed snumoc siam setnega so os HNIA e anoripid ,)SAA( ocilcilasliteca odic .HNIA a e socisglana a seaer ed oatneserpa ed snumoc siam samrof sa os amedeoigna e aircitrU )HNIA( sianomroh-on soirtamalfniitna e socisglanA .71setneicap ed opurg esse osicerp moc railava levssop ,nosrettaP e etrawSeD ed o omoc ,sodalumrof meb solocotorp es -odnazilitU .siacol socistsena moc oudortnier ed e soen -tuc setset racilpa levdnemocer res edop ,missA .atsit -ned-oigruric oa omoc etneicap oa otnat ,anaruges moc receralcse oirssecen siacol socistsena soa edadilibisnes -repih ed oaer ed edadilibaborp aneuqep ad rasepA .42o -aer maratneserpa on oudortnier soditembus marof setneicap siod setse odnauQ .sataidemi saud odnes ,soen -tuc setset soa seaer srt sadacifitnedi marof setneic

-ap 771 ed opurg ortuo mE .32avitisop oaer reuqlauq mar -artnocne on e siacol socistsena a oaer ed airtsih moc setneicap 632 soentuc setset rop marailava la te nukreB .ociglonumi omsinacem moc uo sacigrla etnemariedad -rev seaer sa sarar odnes ,lagavosav omsinacem mereg -us siacol socistsena soa sadaicossa seaer sa ,missA .sacigrla-oduesp uo sacigrla seaer ed sosac sod %09-08 me megrus setitamred euq radrocer elaV .)aircitru uo odirurp( saen -tuc seatsefinam ed aicnsua a aton ed ongid e o -acidem ed edadissecen mes mevloser seaer satsE .se -anibmoc sairv saus san uo otnujnoc me rigrus medop samotnis setsE .oiamsed ,etnemlautneve e laicaf ametire ,oacofus ed oasnes ,atnagrag an uo otiep on otrepa ,arutnot ,aesun ,ratse lam :os siapicnirp saxieuq sA .siacol socistsena magerpme euq sotnemidecorp etnarud oaer ed samrof sadairav siam sad otaler o mumoc siacol socistsenA -

aniropsola fec razilibisn esse d -2 u o , a v i t a n r e t l a a g or d e s u - 1 razilibisn es sed uo lau da rg a mrof ed racilpA

ovitisoP ovitageN

aniropsolaf ec o aer ed airtsih moc e tneicap me aniropsola fe c ed osU

l a r e t a l a i e d a c e d o p i t o r t u o et n e s e r p a e u q a n i r o p s o l af e c r a s U anilicinep razilibisn esse d -2 uo ,avit an retla agord racilpa -1 anilicin ep racilpA aniropsola fec oazilibisn esse d -3 u o , a n i r o p s o l a f e c m o c a v i t a d a r g o u d or t n i e r e s u - 2 u o , a g or d a r t u o e s u - 1 aniropsola fe c a racilpA

)a dazinordap on acinc t( Lm/gm 3 ed .cnoc a n aniropsolafec avon a moc oen t uc etseT et s e t mes racilpA ovitisop etseT ovita gen anilicinep moc etseT ovitisop etseT ovit ag en etseT

aniropsolaf ec o aer ed airtsih moc e tneicap a anilicine p ed oacilpA

anilicinep oa er ed airtsiH

aixalif ana et s e t rer roco edoP .sa roh 42 m e o aer r at nes erp a m edop s etneica p sod %1 ed soneM mes racilpA .set necer si am saniropsola fec ra su rarucorp ,oir s sece n osaC .anilicin ep o aer ed airtsih mt on eu q seleu qa euq od roia m m rop ,saniropsolafe c s o aer ed odizu der ocsir met anilicin ep o ae r ed airtsih moc etneic aP .ocim tcal-at eb len a o ar ap o n e siare tal saie dac sa ar ap sacifce pse o s saniropsolaf ec s sea er satiuM

sa nirops olafeC
ocitibit na ortuo racidni :ovitisop etseT .anilicin ep ar ap oda dn emocer omoc ri u gessorp ,ovita ge n rof et set o es :anilicin ep m oc oen t uc e tse t rezaF anilicinep ed oacidnI ralupapoluca m h sar od e tnerefid ,anilicixoma moc roire tn a o aeR

anilicix oma ,anilicipmA


adacidni latot esod a racilp a o ae r r at ne ser pa o n eS .aroh 1 ra dr augA .e sod a d 0 01 /1 racilpA laro anilicin ep moc laicini esod r asu le vd nemoc er re s edoP .ocsir on euq ep moc anilicin ep r asu edoP ocitibit na ortuo razilitU laro anilicinep moc laicini esod ra su lev dne mocer r es e doP .aletu ac moc anilicin ep racilpA o a e r r a t n e s er p a e d % 0 5 e u q r o i a m e c n a h C G neP moc ovitageN ovit ag en etseT ovitisop etseT ovit ag en etseT ovitisop etseT avita gen uo avitisoP avita gen uo avitisoP avita gen uo avitisoP avitisop airtsiH avitisop airtsiH

anilicineP
seralimis e saniropsolafec ,anilicipma ,anilicin ep a aigrela ed sotieps us s etneic ap me edutitA - 4 ordauQ sot ne macidem a aigrelA

921

5 00 2 ,3 N ,82 .loV .lot aponumi .grela .sa rb .ve R

.sosoiccefni setnega e anitaleg omoc ,setnenopmoc sortuo a oaer )4 e ,sanicav san sod -itnoc socitibitna a seaer )3 ,searaperp samugla me etneserp oircrem oa edadilibisnes )2 ,ovo ed sonegtna soa sadanoicaler seaer )1 :os snumoc siam seaer sa 43xoddaM e naadaM odnugeS .sanicav sad setniutitsnoc soa sadanoicaler otse edadilibisnesrepih ed seaer sA .erbef rerroco edop mbmat e amede e ametire ,rod moc ,onegnumi od oacilpa ad lacol on seaer snumoc oS .setneq -erf os on sanicav a edadilibisnesrepih ed seaeR sacingonumi sanicaV .oacidem ad adairporpa oartnecnoc a moc socimrdartni soentuc setset rop otief res edop oazilibisnes ed ocitsngaid O .EgI rop sadaidem res on medop samuglA .siat -af os seaer satsed %01 euq odnes ,saisetsena 000.01 adac me oaer amu erroco teolvreV odnugeS .sevarg seaer rizudni ed ocsir roiam o matneserpa ).cte ,muinor -uvev ,muirucarta ,muinotemaxus( seralucsum setnaxaler so lareg aisetsena me sadasu sagord sasrevid sa ertnE seralucsum setnaxaleR sotnemacidem ed avitadarg oudortnier a moc uo oazilibisnessed a moc maicifeneb es setneicap ses -sed sotiuM .acinlc ossucreper ed e edadisnetni ed mairav seatsefinam sA .siarivorteritna sagord sa moc uotsefinam es ,riuges A .miportemirt-lozaxotemaflus moc odaton iof etnemlaicini otsI .sotnemacidem a seaer ed atla otium aicnqerf matneserpa VIH moc sodatcefni setneicaP VIH olep ocefnI .adalortnoc avitadarg oudortnier rautefe uo oacidem-rp rerrocer ,lauta oircserp a racort levhl -esnoca res edop oailava a emrofnoC .)6 ordauq( oail -ava an ossecus retbo ed edadilibissop roiam e etneicap oa anaifnoc arugessa adazinordap atudnoc amu riugeS .13cte ,oacilpa ed aiv ,otneve oa sodaicossa sotnemacidem ,)s(aivrp )se(oaer )s(ad asicerp airtsih odnecelebatse ,sotnemacidem a aigrela ed oagitsevni ed acisslc anitor a riuges oirssecen etneicap ed opit etsed ojenam oN

sot 13,03 -nemacidem a sasrevda seaer a aicnrefer roiam rat -ilicaf edop etneicap od ociuqsp odatse o euq oralc ecerap ,odal ortuo roP .oacidem ad oacilpa ed aiv e acinrc aircitru ,HNIA e SAA a edadilibisnesrepih ,anilicinep aiv -rp oaer :omoc ,sotnemacidem a seaer ed aicndicni roiam sodaicossa ratse mecerap euq serotaf metsixE .odamrifnoc res a otaf sagord salpitlm a oaer ed emordns acinlc emordns amu atneserper edadilibisnes -repih ed opit etse eS .lairotalubma otnemidneta me mb -mat e sodanretni setneicap ed ocinlc ojenam o ratlucifid edop socitibitna soirv a edadilibisnes ed aicnrefeR .03ocinlc atsigrela o arap oifased oriedadrev mu setneicap ed opurg etsE .lareg me sotnemacidem rasu ed oiecer met euq e seacidem saremni a seaer mataler euq setneicap odigrus mt sona somitl soN sagord salpitlm a oaeR .setsartnoc soa seaer ed osnetxe a riunimid uo ridepmi odiugesnoc met )2H-itna a on uo sadaicossa( 1H-itna sagord ,sediretsocitroc odnagerpme sameuqse moc oacidemerP .92otnemidecorp od setna etneicap o racidem ed oacidni h seisaco satrec mE .setsartnoc soa se -aer ed oneverp a arap ocitsngaid odotm etsixe oN .sotudorp sesse a seaer ed ocsir o ratnemua arap riubirtnoc edop HNIA ed e SAA ed ,serodaeuqolbateb ed osu O .aipota ed airtsih e etsartnoc a aivrp oaer ,aciuqnrb amsa :setsartnoc soa seaer arap ocsir ed serotaf oS .sotnemacidem a saivrp seaer ed uo aipota ed airotsih moc etneicap odot arap sediretsocitroc e socinmatsih-itna moc oacidem-rp ed oazilitu a mazinocerp socitsngaid ed sortnec snuglA .82%2,0 ed socini-on so moc e %21 a %11 ed socini sotudorp moc seaer ed aic -nqerf a nagaH odnugeS .sotneve sessed aicnlaverp an ouder avitefe uonimreted socini-on e edadiralomso ron -em moc sotudorp ed otnemivlovnesed O .semrofitalifana uo siagavosav ,sarotomosav res medop seaer sA .soc -igloidar setsartnoc a sasrevda seaer sa snumoc oS socigloidar setsartnoC -

bixocedlav ,bixocefor ,bixoceleC macixolem ,edilusemIN otaticilas ,loma te car aP .cte ,ocanefolcid ,ocim n efem odic ,ot am anefolce m ,ne forponef ,one xorpa n ,oneforpubi ,nitemlot ,cidnilu s ,anicatemodni ,macixoriP

a da zurc o ae r erroco o n ;1-XOC mebini o n ,2 -XOC ed soviteles serodibinI s ear tn ecn oc satla me 1-XOC mebini m bma t s am ,2 -XOC etnemlaic ner efe rp mebini e uq sagorD sea rt necnoc satla ma e tn emos e 1 -XOC a d soca rf serodibini o s e uq sagorD SAA m oc a da zurc o ae r ma tne ser pa e 1 -XOC etnemlaic ner efe rp mebini e uq sagorD

72

sia nomroh -on soirtamalfniitna e ocilcilasliteca odic e rt ne a daz ur c oa eR 5 ordauQ

.HNIA e socisglana ed sopit soirv e SAA rop oaer ed edadilibissop a erbos sodad mtnoc 1 alebat A .62soc -isglana a oaer odatneserpa maivah acnun euq seleuq -an omoc SAA a sievsnes etnemaiverp setneicap me otnat ,sotudorp setse moc seaer martsiger es mbmat ,aiv -adoT .setneicap ed opurg etsen siet res medop )2-XOC( 2-esanegixoolcic ad siaicnereferp serodibini sO .HNIA soir -v so e SAA ertne adazurc oaer rerroco mumoc .52,81sacitsretcarac sacinlc seatsefinam sa odnacovorp sodicet sosrevid e elep an
sot nem acide m a aigrelA

soirtamalfni serodaidem sortuo e animatsih marebil ,sad -avita zev amu ,salulc satsE .sotictsam erbos arotetorp edadivita aus ad adrep e 2EGP ed sievn sod oiunimid odnacovorp ,esanegixoolcic amizne ad edadivita ad oieuq -olb erroco setneicap sesseN .EgI soprocitna ed oamrof a evlovne on sanairacitru seaer sassed omsinacem O .HNIA e anoripid ,SAA oa etnemavissecus oaer mavlovnesed saossep sa euq etneqerf .seled soirv a uo sotnemac -idem sessed mu a etnemadalosi rasserpxe es edop edadiv
5 0 02 ,3 N ,82 .loV .lota ponumi .grela .sa rb .veR

031

.6 .5

.4 .3 .2 .1

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saicnrefeR

.acituparet oacidni amsem a moc sianoicpo seacidem sa e ;seaer savon rerfos a reiv es ocsir o ;adazurc oaer ed edadilibissop moc sagord ;)sair -teirporp sacram ed e ocirneg( etnaedacnesed etnega ed emon :uotneserpa euq acinilc oidnoc a erbos o -amrofni adot rebecer eved etneicap O .soidsipe sovon ed oneverp a , otsi ,aduga esaf a spa oatneiro a )sen -umi-on uo senumi( sagord a edadilibisnesrepih ed se -aer sad ojenam on setnatropmi siam sapate sad amU oneverP .acinlc arohlem ad zedipar a e ocitsngorp o rohlem acigrl -aitna oacidem ed osu o moc onevretni a ecocerp siam otnauQ .ralatipsoh oanretni rereuqer medop sevarg siam sociglotamred sordauq sO .samotnis sod elortnoc arap said snugla rop laro aiv rop sediretsocitroc ed edadissec -en revah edop edadisnetni roiam ed sosac mE .acinlc o -ulove alep odanimreted res osu ed opmet O .oirtadnam socinmatsih-itna ed osu o amedeoigna e aircitru ed sotrus soN .anidanefoxef e anidatarolsed ,aniziritec omoc ,)setnades ocuop uo setnades-on( oareg 2 ad socinm -atsih-itna ed oacidni h odirurp odnerrocO .oacidem mes ,etnemaenatnopse rarohlem medop sacitmetnaxe sepurE .osu ues o rednepsus edutita ariemirp a otnem -acidem a oaer ed ovitsegus ocinlc ordauq a etnerF

oneverp e otnematarT

)5 )4 )3 )2 )1

.43seaer sariemirp sa e seazilibis -nes sa odnineverp somaratse amrof atseD .sagord a se -aer rerfos ed ocsir roiam moc setneicap racifitnedi mes -sitimrep euq sacinct revlovnesed e sagord sad omsilobat -em od otnemicehnoc o ratnemua a odigirid res aireved sac -itsngaid sacinct raromirpa me etnatsnoc ohnepme O .sievtecsus etnem -aciteneg saossep sa racifitnedi ed soiem metsixe on e sagord sad sacingonumi saluclom sa ecehnocsed es euq zev amu setneicifed mecenamrep oagitsevni ed sodotm sO .sotnemacidem a aigrela ad ocitsngaid on uocifidom es ocuop sadacd samitl san sacitsngaid sacinct sad e otnemicehnoc od oulove airnidroartxe ad rasepA .sortuo e ,sanicotic ,sianolconom soprocitna omoc ,socigloib sotud -orp ed oazilitu ad e sotnemacidem sovon ed oazilibin -opsid ad aicnqesnoc me sona somixrp son seaer sas -sed aicndicni ad otnemua reverp levssop .lairotalubma acitrp an mumoc sotnemacidem a edadilibisnesrepiH

)oazilibisn ess ed e d onalp r eceleba tse ( aivrp oazilibisne sse d moc oda su re s edop etnemos ocitibitnA )o udortnie r e d onalp r eceleba tse( o udor tnier ed e tse t rarelot es od asu res edop ocitibitnA ) o t n e m a t a rt - r p e d o n a l p m u recele bat se( otne ma ta rt -r p moc od asu res edop ocitibitnA odative es eved ocitibitnA acinlc oacidni revit es od asu res edop ocitibitnA

savitcepsreP

oa ilava ad lanif oa ovitefe otnema tar t ed onalp mu a rap se dad ilibissoP -

acitsc esorbif ,VIH olep ocefni ,aicnicifedonumi ,lan er an eod ,acit peh aneod ,HNIA a aicnrelotni ,omsifa rgom red ,acinr c aircitr u :ocsir ed s e r o t a f s e t n i u g e s s o , s e t n e s er p e s , r a t n e m u c o d e r a g i t s e v n I oisopx e amitl a d a tad a e s a s r e v d a s e a e r m o c s a d a i c o s s a s a g o r d s a s a d ot r a t s i L

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