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IN1kCDUC1ICN

SLress and aglng can cause memory and concenLraLlon Lo fade 1hls ls based on sLudles LhaL
cellular meLabollsm produce free radlcals LhaL may cause neuron degeneraLlon and memory lmpalrmenL
(8ao 2008) uue Lo Lhls researches have made rlgorous aLLempLs Lo dlscover percepLual and processlng
sLraLegles LhaL may enhance reLenLlon of lnformaLlon 1he lncreased popularlLy of memory enhancers ln
Lhe markeL ls based on need Lo lmprove memory capaclLy for work and educaLlon
lor medlcal sLudenLs who are leadlng a sLressful llfesLyle whlch lncludes lack of sleep and
unhealLhy dleL lnLroducLlon of a naLural memory enhancer supplemenL could be beneflclal
AnLloxldanLs were proven Lo lmprove neuron generaLlon and cognlLlve funcLlon (Pead 2008)
varlous frulLs vegeLables and herbs conLaln dleLary flavonolds whlch show poLenL anLloxldanL effecL
Cne herb whlch has hlgh concenLraLlon of flavonold and Lhus has hlgh anLloxldanL properLy ls 2loqet
offlcloole commonly known as Clnger (Chasemzadeh eL al 2010) 8ased on a sLudy Clnger has
demonsLraLed a cognlLlve enhanclng effecL and neuroproLecLlve effecL agalnsL focal cerebral lschemla ln
raLs maklng lL a promlslng memory enhanclng naLural supplemenL for humans (lngkanlnan eL al 2011)
ln Lhls sLudy Lhe memory enhanclng beneflclal effecL of Clnger (2loqet offlcloole) wlll be LesLed
on Lhe Mlndanao SLaLe unlverslLy College of Medlclne sLudenLs and wlll be evaluaLed by uslng a
modlfled memory Span 1esL (Card 1esL)

C8ILC1IVLS CI 1nL S1UD
Genera| Cb[ect|ve
1o lnvesLlgaLe Lhe memory enhanclng effecL of Lhe 2loqlbet offlcloole capsule among medlcal sLudenLs
of MSuCollege of Medlclne
Spec|f|c Cb[ect|ves
1 1o deLermlne lf Lhere ls slgnlflcanL dlfference beLween Lhe effecLs of 2loqlbet offlcloole capsule
and Lhe placebo ln Lhe enhancemenL of memory among 1
sL
year medlcal sLudenLs
2 1o deLermlne lf Lhere ls an lmprovemenL ln Lhe memory of Lhe sub[ecLs LreaLed wlLh 2loqlbet
offlcloole based on a modlfled Memory Span 1esL (card LesL)
nC1nLSIS
P
0
1here ls no slgnlflcanL dlfference beLween Lhe effecLs of 2loqlbet offlcloole and placebo on Lhe
memory enhancemenL among Lhe 1
sL
year sLudenLs of MSuCollege of Medlclne
P
1
1here ls slgnlflcanL dlfference beLween Lhe effecLs of 2loqlbet offlcloole and placebo on Lhe memory
enhancemenL among Lhe 1
sL
year sLudenLs of MSuCollege of Medlclne

SCCLS AND LIMI1A1ICN
1 1he sLudy ls llmlLed Lo Lhe admlnlsLraLlon of 2loqlbet offlcloole capsule (300 mg) once a day for
LhlrLy days
2 1he sLudy lncluded only random sLudenLs from baLches 20132013 of MSuCollege of Medlclne
3 1he sub[ecL's dally dleL and acLlvlLles were nelLher recorded nor accounLed conLrolled or
modlfled
4 LxperlmenLal sub[ecL lnclude only Lhose wlLhouL hlsLory of head Lrauma surglcal procedure
normoLenslve (8lood pressure below 130/90 mmPg) and nondlabeLlcs wlLh a caplllary fasLlng
glucose of 70 mg/dL Lo 110 mg/dL
3 1he sLudy was llmlLed Lo Lhe use of a modlfled Memory Span 1esL as a Lool for Lhe
deLermlnaLlon of memory enhancemenL
SIGNIIICANCL CI 1nL S1UD
1hls sLudy was conducLed Lo provlde accesslble readlly avallable and lnexpenslve alLernaLlve
supplemenL for memory enhancemenL of randomly selecLed medlcal sLudenLs Slnce Medlclne requlres
every sLudenL Lhelr uncondlLlonal enLhuslasm as well as lL challenges Lhem numerous sLrenuous menLal
acLlvlLles Lhe medlclnal value of Lhls herb may ald ln memory enhancemenL lLs avallablllLy also plays a
good facLor of regardlng lL as a good source alLernaLlve ln comparlson Lo expenslve and branded
producLs lf proven Lo enhance memory













ML1nCDCLCG
l 8esearch ueslgn
a 1he sLudy ls a randomlzed doublebllnd placebo conLrol sLudy for 30 days wlLh pre and
posL screenlng and memory LesL
ll SlLe of Lhe sLudy
a 1he sLudy wlll be conducLed ln Mlndanao SLaLe unlverslLy College of Medlclne lllgan
ClLy
lll SLudy opulaLlon
a SlxLy SLudenLs of Mlndanao SLaLe unlverslLy College of Medlclne from flrsL year Lo Lhlrd
year
lv Sub[ecL SelecLlon
a lncluslon CrlLerla
l SlxLy SLudenLs of Mlndanao SLaLe unlverslLy College of Medlclne from flrsL year
Lo Lhlrd year wlLh cl8Cof 80120 mg/dL Lhrough glucomeLer
b Lxcluslon CrlLerla
resence of any of Lhe followlng excludes Lhe sub[ecL from Lhe sLudy
l lndlvldual sufferlng from any condlLlon LhaL may affecL Lhe general healLh durlng
Lhe course of Lhe sLudy and Lhose who have a hlsLory of head Lrauma
ll lndlvlduals who are dlabeLlcs wlLh famlly hlsLory of dlabeLes or have a cl8C80
mg/dL and 120mg/dL
lll lndlvlduals who are pregnanL
lv lndlvlduals who are Laklng medlcaLlon LhaL can affecL Lhe memory (Memory
lus) or lncrease Lhe blood glucose level durlng Lhe conducL of Lhe sLudy
v reparaLlon of Lhe MedlcaLlon
a Clnger rhlzomes wlll be washed cuL and ovendrled lL wlll Lhen be pulverlzed uslng an
elecLrlc blender
b llve hundred mllllgrams (300mg) of Lhe powder wlll be welghed uslng an elecLronlc
welghlng balance and wlll be puL lnslde Lhe capsule SufflclenL number of Lhe drug wlll
Lhen be packed and labeled accordlngly
vl reparaLlon of Lhe lacebo
a lacebo wlll be made from corn sLarch colored wlLh food colorlng whlch wlll be lnlLlally
heaLed drled and cooled
b llve hundred mllllgrams (300mg) of Lhe placebo wlll be welghed uslng an elecLronlc
welghlng balance and wlll be puL lnslde Lhe capsule Also sufflclenL number of Lhe
placebo wlll Lhen be packed and labeled accordlngly
vll re and osL 1esL of Lhe Sub[ecLs
a 1he sub[ecLs wlll be LesLed uslng Lhe Card 1esLModlfled Memory Span 1esL before
glvlng Lhe glnger and placebo capsules 1he LesL wlll conslsL of cards Lo be shown Lo Lhe
sub[ecLs for 3 mlnuLes 1he sub[ecLs wlll be asked Lo memorlze Lhe conLenLs of Lhe
cards AfLer whlch Lhe sub[ecLs wlll be asked Lo reclLe Lhe conLenLs of Lhe cards wlLhouL
looklng aL Lhe cards Scores wlll be counLed based on Lhe correcLlynamed cards 1hls wlll
serve as a basellne score
b Same process wlll be done wlLh dlfferenL seL of cards afLer 13 days of LreaLmenL
vlll lan of ulsLrlbuLlon
a 1he slxLy sLudenLs wlll be dlvlded lnLo Lwo groups
b Lach member of Lhe Croup A wlll recelve 13 glnger capsules Cne capsule per day
should be Laken afLer breakfasL for 13 days
c Lach member of Lhe Croup 8 wlll recelve 13 placebo capsules Cne capsule per day
should be Laken afLer breakfasL for 13 days
d 1he labels wlll be kepL confldenLlal
e AfLer 13 days Lhe sub[ecLs wlll be lnLerchanged for anoLher 13 days Lrlal


















SCnLDULL CI AC1IVI1ILS
-ovember
3
rd
week 8esearch roposal llnallzaLlon
4
Lh
week 8esearch roposal llnallzaLlon
uecember
1
sL
week reparaLlon of producLs and Lools for Lhe LesL
2
nd
week reparaLlon of producLs and Lools for Lhe LesL
3
rd
week 8andom SelecLlon of sLudenLs 30 conLrolled and 30 placebo
4
Lh
week 8andom SelecLlon of sLudenLs 30 conLrolled and 30 placebo
!anuary
1
sL
week ConLrolled sub[ecLs glven Lhe producL and evaluaLed durlng Lhe 1
sL
and lasL day
2
nd
week ConLrolled sub[ecLs glven Lhe producL and evaluaLed durlng Lhe 1
sL
and lasL day
3
rd
week lacebo sub[ecLs glven Lhe placebo and evaluaLed durlng Lhe 1
sL
and lasL day
4
Lh
week lacebo sub[ecLs glven Lhe placebo and evaluaLed durlng Lhe 1
sL
and lasL day
lebruary
1
sL
week LvaluaLlon and analysls of Lhe resulLs
2
nd
week CorrelaLlon of Lhe resulLs and flnallzaLlon of Lhe research paper