Pathophysiology:

Age, Sex, Geographic, Season

Leptospire
from infected animals

Direct invasion of tissue on susceptible host; induced endotoxins,hemolysin & lipase

capillary vasculitis

endothelial edema, necrosis, lymphocytic infiltration

loss of RBC & fluid via enlarged conjunction & fenestrae

CBC PT Petechiae, intraparenchy mal bleeding, bleeding along serosa & mucosa; thrombocytope nia Jaundice, vascular congestion & disorganizati on of liver cell plates Alveolar capillary

x-ray

urinalysis

ECG

Tubular necrosis, interstitial nephritis

Cardiac lesions, epicardial & endocardial petechiae, myocardial interstitial edema, coronary arteritis

Hemorrhage, focal necrosis, infiltration within the adrenal gland

injury (focal/ diffuse), interstitial & intraalveolar edema & bleeding, frank hemorrhage