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Nov 2011- Kuliah 3143 Fisio MAIMON-Digestion & Nutrition

Nov 2011- Kuliah 3143 Fisio MAIMON-Digestion & Nutrition

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LECTURE 2-4 (November-December 2011 PROF MAIMON) FISIOLOGI SEKITARAN AND MONITORAN DIGESTION AND NUTRITION - Energy for

Maintenance, Growth, Reproduction, and Storage must come from food. There are 3 major aspects in dealing with food: 1) Feeding 2) Digestion 3) Nutrition I. FEEDING – almost all organic matter used by animals as food can ultimately be traced back to the use of sunlight by plants to synthesize sugars.

Types of Food

1) Dissolved Food a. Many aquatic invertebrates (and some algae) can extract organic molecules from solution, sometimes against very high concentration gradients by active uptake
b. Parasitic animals living in rich environment of host tissues take up “food” from host tissues. Body surfaces resemble intestinal epithelia in function.
c.

Sulfide-oxidizing Bacteria – occur at deep sea hydrothermal vents. Total darkness so no capacity for photosynthesis (primary productivity limited to first 300 m of water column) and very little organic matter reaches these depths (>2500 m). Also it is cold (2-3°C).

- In spite of these features of the deep sea environment, at hydrothermal vents there are high animal densities. Why? - (i) temperature at vents higher - (ii) high H2S concentrations in water issuing from vents

. they house a large population of symbiotic sulfideoxidizing bacteria within an organ called a trophosome.(iii) sufficient oxygen away from immediate vent outlet (SEE REFERENCE TEXTBOOK. ii) iii) (SEE REFERENCE TEXTBOOK. HAINSWORTH.G. E. Instead. but only tentacles are in direct contact with water so not much S. PROSSER ) - Primary producers in these communities are bacteria that have enzymes necessary to catalyze the oxidation of hydrogen sulfide and utilize energy released by this oxidation to drive the net fixation of CO2. .These are the only communities known where primary productivity is not driven by sunlight.+ ATP + NADPH - . PROSSER ) . How do they utilize carbon fixed by sulfideoxidizing bacteria? i) One possibility is extraction of organic matter from water. Hydrogen sulfide taken up by tentacles → transported by closed circulatory system to trophosome → bacteria oxidize hydrogen sulfide and ATP and NADPH produced drive carbon fixation and nitrate reduction.G. HAINSWORTH.A.Filter feeders and grazers (bivalves and limpets) can then feed on these bacteria and carnivores can then prey on these consumers (crustaceans and fishes serve as carnivores) - One of the dominant vent animals is a tubeworm (Riftia) that lacks a digestive system. Symbiotic bacteria also found in gills of vent clam and vent mollusc. E.+ ADP + Pi + NADP ⇔ SO42. O2 + HS. for absorption.

etc. and absorption of digested nutrients. then eat entire mass (some aquatic invertebrates) Ciliary Filter Feeding = cilia create currents that carry food to be trapped by mouth or by mucous tissues that trap particles and carry them to digestive system. DIGESTION = breakdown of large. Large Food Masses – numerous adaptations occur for processing large volumes of solid or liquid food. digestion takes place within a digestive tract (extracellular digestion). leads to increased absorption) a.Specific digestive enzymes are responsible for breakdown of carbohydrates.. fats. . fats. the digestive tract becomes specialized.A. complex molecules in food (proteins. with regions for mechanical processing. . . and proteins. Spiral Valve in Elasmobranchs.) 3. also less well developed spiral valve in some other fish. chemical digestion. paddlefish. flamingos. but in more advanced invertebrates and all vertebrates. DIGESTIVE ADAPTATIONS IN VERTEBRATES 1) Adaptations to increase intestinal surface area for absorption (increased S.Protozoans and some primitive invertebrates rely on intracellular digestion. II.g. Particulate Food a) b) c) d) Phagocytosis – protozoans Mucoid Feeding = secrete mucous sheet that traps particles. baleen whales.In vertebrates. carbohydrates) into small molecules that can be absorbed and used by the body. (numerous invertebrates) Suspension Filter Feeding = suction-created or waterstream currents carry particulate matter over structures that trap matter and deliver it to the digestive system (e.2. .

Wood Rats had a small intestine 1.allows digestion of cellulose. To compensate.8X and a large intestine 6. Small birds wintering in cold regions may fill crop with seeds prior to nightly roosting . d. cannot chew food to increase the surface area susceptible to digestion. especially granivores and herbivores.g. Elongation and Coiling of intestines (Teleosts through mammals) Folding of gut lining and microvilli on intestinal cell surfaces (SEE REFERENCE TEXTBOOK. 30-40% of energy in mature foliage assimilated 2) SPECIAL DIGESTIVE ADAPTATIONS IN VERTEBRATES Birds lack teeth and. which .8X longer than those in a similar-sized iguana when both were fed alfalfa pellets).. f. a) b) - Fermentation Symbioses . May be important to extending fasting endurance.G.can then use food stored in crop as extra energy reserve overnight. HAINSWORTH. Digestive Efficiencies of Birds on Different Diets: Hummingbirds = 97-99% of energy in nectar assimilated Raptors = 66-88% of energy in meat assimilated Granivores = 49-89% of energy in seeds assimilated (depending on seed type) Herbivores = 60-70% of energy in young plants assimilated. Many birds. therefore.b. Endotherms typically have longer intestines with increased surface area than ectotherms of similar size on a similar diet (e. Herbivores have longer and more complex intestines than carnivores due to the increased difficulty of digesting plant matter. birds have thick muscular-walled gizzard (corresponds to posterior portion of stomach) with keratinous lining that aids in grinding food. PROSSER) - - e. c. Granivorous and piscivorous birds also have a Crop = outpocketing of esophagus serving food storage function. E. swallow pebbles that lodge in gizzard and aid in mechanical breakdown of food.

(ii) Hoatzin = obligate folivorous bird from Neotropics. and Cervids: deer. giraffes. because bacteria (and protozoans) that can break down cellulose are housed in specific regions of digestive tract. pronghorns. HAINSWORTH.also occurs in tree sloths.Digestive Efficiency = 71% (compared to 30-40% without fermentation) . (i) Ruminant Mammals . some monkeys. (SEE YOUR REFERENCE TEXT FOR ILLUSTRATION) Ruminant-like Digestion .serves as fermentation vat where symbiotic microorganisms break down cellulose so that it becomes available for further digestion. some rodents. Fermentation products = volatile fatty acids. . PROSSER FOR ILLUSTRATION OF SYSTEM) (iii) Hindgut Fermentation (performed by cecae) . harbor cellulose-digesting symbiotic microorganisms. and kangaroos and wallabies.includes Bovids: cattle. E.Reticulum = also serves as fermentation vat. This type of cellulose digestion is less effective than foregut fermentation because the microbial breakdown .G. goats.Omasum and Abomasum = remasticated material bypasses rumen and reticulum and enters omasum (mechanical processing) then abomasum (corresponds to normal mammalian stomach).Cecae = diverticula from the lower intestine. Undigested fibrous material is regurgitated as cud. . antelope.First and largest = Rumen . sheep. . Utilizes foregut fermentation with bacteria that break down cellulose (similar to ruminant digestion in mammals. camels.animals lack the enzymes to digest.Enlarged muscular crop and lower esophagus serve as main fermentative structures (SEE REFERENCE TEXTBOOK. stomach consists of several compartments .

E.25. and 50 times greater in hummer than in shrike. and Loggerhead Shrike (carnivore) .G. but reflux is common within digestive tract. Both carbohydrate and amino acid transporters are linked to Na+ co-transport. . elephants.Hindgut fermentation has been documented among herbivorous members of all groups of vertebrates except amphibians. - . Example: Willow Ptarmigan (Alaska) eats willow buds and twigs over the winter. Chicken = 0. G/P Ratios: Hummer = 5. HAINSWORTH. .19. Cecal fermentation of these foods can account for 30% of basal energy requirements. Chicken (omnivore).Cecal fermentation may still contribute substantially to energy provision. 3) NUTRIENT UPTAKE FROM INTESTINE - Both simple carbohydrates (mono. . Among mammals: horses. (SEE REFERENCE TEXTBOOK.95.does not occur until after the stomach and small intestine. PROSSER ) . glucose uptake 15 times greater in hummer than in chicken. 1986.and disaccharides) and amino acids are taken up from the intestine by transporters. Transporters are membrane proteins that actively (require ATP) take up nutrients from intestine.Differences in G/P Ratios reflect differences in numbers of intestinal glucose transporters. several herbivorous marsupials. Results: Proline uptake similar.This is illustrative of the general trend for vertebrates. Do Nutrient Transporter Activities Differ in Accord with Diet?? - Experimental: Comparison of glucose and proline uptake activities in Rufous Hummingbird (nectarivore). some rodents. G/P Ratios in Herbivores > Omnivores > Carnivores. Reflux necessary to absorb nutrients from digested cellulose.Karasov et al. Shrike = 0.

the biosynthetic cost of glucose transporter production has been eliminated. content of carnivore diet is low. diet showed decreased proline and increased glucose transporter activity. . Also supporting this conclusion is the demonstration that glucose uptake appears unresponsive to dietary carbohydrate in strict carnivores. . 3 carnivores maintained on commercial trout food for > 8 weeks. E. herbivores > omnivores > carnivores. .g.4 herbivores. HAINSWORTH. (1987) tested this possibility with fish .Why are Amino Acid Uptake Activities Similar for All Vertebrates?? .What happens to transporter activities with these ontogenetic changes?? - Mammals . - - ONTOGENETIC CHANGES IN DIET .(SEE REFERENCE TEXTBOOK. Conclusion: Indicates genetic component to transporter activities.. PROSSER) Could Trophic Differences in Transporter Activity be Due to Differences in Diet Rather than Genetic Differences?? - Experimental: Buddington et al. Since the carbo.G. mouse switched from high protein-no carbo. used for calories only. Results: G/P transporter ratio still showed same pattern. uptake. rather than proline. regardless of their trophic habits (similar levels required in all vertebrates. 2 omnivores.diet of suckling young is high in lactose (milk sugar). Carbos.Transporter activities (# of copies) in most cases can be modified by diet (e.Amino acids are essential for all vertebrates. diet to low protein-high carbo. Differences were due to glucose.Many vertebrates show changes in diet from larvae/juvenile stage to adult -.

) as tadpoles. 4) DIGESTIVE RESPONSES TO SEASONAL CHANGES IN DIET . . . Rats and rabbits show increased fructose transporter activity at time of weaning.Probably due to higher amino acid requirements of juveniles relative to adults (higher amino acids required lead to higher levels of amino acid transporters in juveniles). but carnivory (low carbo. increased intestinal transport of glucose and tyrosine (an amino acid). . Sheep show decreased glucose and galactose transport activity at weaning.Dietary switches between seasons are relatively commonplace in animals./Protein ratio in diet also increases as juvenile development proceeds in several vertebrates. rats).Increased turnover time apparently more affected by high energy demands associated with low temperatures than by low quality diet.switches to a high fiber diet in winter when energetic costs are high. this switch generally involves changing from and insect diet to an herbaceous diet. .G/P Ratio rises throughout juvenile development for a number of vertebrates (fish. Why does G/P Ratio Increase During Development Irrespective of Dietary Switch?? . but not for many frogs which exhibit herbivory (high carbos.In tadpole to adult metamorphosis.. as ruminant digestion in adults results in little carbohydrate reaching intestine. and increased turnover time for digestive contents.carbos. also get decrease in intestinal length with switch from herbivory to carnivory. particularly for winter-active (non-hibernating) endotherms. Carbo. high protein) as adults. . in adult diet differ. Responds by hypertrophy of gut. EXAMPLES: a) Andean Mouse . frogs.For insectivorous species.

usually associated with seasonal changes in food availability. DIGESTION AND PLANT SECONDARY COMPOUNDS . fruits and nuts contain a wide variety of plant secondary compounds that are toxic to animal physiological systems. birds on pure fruit diets exhibit mass loss. (2) digestive enzyme activity.Plants.seasonal switch between insects and fruit common for a number of birds . high bulk (Digestive Efficiency = 51-64%) . Recent evidence also indicates that birds will alternate between eating fruit only and insects only. high carbo. However. and (3) turnover time.Often.Switch usually accompanied by changes in gut morphology (increased length and surface area for fruit diet). as digestive efficiency is increased for either food item in the absence of the other (e.b) Birds . . Insects = high protein..cache acorns in fall and use as a major food source in . low turnover times allow high consumption rates that may be adaptive since fruits are an ephemeral resource with low nutrient content but high bulk.. (Digestive Efficiency avg. Animals often have evolved capacities for detoxifying or tolerating plant toxins enabling them to utilize them as food sources. which suggests that fruit diets must be supplemented with foods higher in nutrient content. Also may cause actual physical damage to gut. . = 77%) Fruit = low protein.Fruits usually with decreased turnover times relative to insects. an insect eaten with fruit is not efficiently digested). . a) Blue Jays .EXAMPLE: Acorns are high in tannins which reduce: (1) nutritional availability of soluble proteins and sugars. low carbo.g. this likely contributes to low digestive efficiency.

etc. still lost mass iii) Fed acorns + 5 g/day acorn weevil larvae.Some amelioration of tannin effects provided by acorn lipid. etc. Acorn Woodpeckers (unlike Blue Jay) capable of maintaining mass on diet of acorns (of certain oak species) alone. taken in largely in the form of proteins and amino acids. can be conveniently divided into two parts: 1) 2) Energy = fuel for internal maintenance and external activity Specific Nutrients = required for proper function of metabolic processes.) obtain significant amounts of amino acids from . minerals.cache acorns as overwinter food source. Digestive Efficiency reduced by tannins. maintained mass . b) Acorn Woodpeckers .fall and winter. . i) Jays fed acorns only lost mass ii) Fed acorns + 1. .However. although tannins still had detrimental effect.5 g/day acorn weevil larvae.Animals with symbiotic microorganisms in digestive tract (ruminant mammals. SPECIFIC NUTRIENTS 1) Nitrogenous Substances – required to replace proteins that are degraded (“turned over”) and for synthesis of nucleic acids. II. . Of the 20 amino acids. In higher animals.3% of total energy demands. essential fatty acids. NUTRITION = adequacy of diet to meet metabolic needs of an organism. include nitrogen-containing compounds. even at high lipid concentrations. comprise up to 16. approximately 10 are essential (animals cannot synthesize on their own) and must be obtained in the diet.Weevil larvae able to overcome low nutrient value and tannins in acorns to allow jays to subsist on a diet composed almost entirely of acorns. vitamins.

Mammals can’t synthesize fatty acids with a double bond at C-3 or C6 from the methyl end of the fatty acid molecule. often function as coenzymes in metabolic reactions . • • Switching of diet locations for Choice treatment group showed that birds could choose high-SAA diet in < 1 day. 2) Essential Fatty Acids = fatty acids that cannot be synthesized by the animal but are necessary components of cell membrane phospholipids and serve as precursors for prostaglandins.In some cases (maybe common) animals can distinguish among diets that are adequate or inadequate to meet specific nutritional needs. Results: High SAA → normal molt. • Experimental: exposed molting birds to two diets differing only in SAA concentration. Also gave one group of birds a choice between the two diets. cysteine and methionine. a) Water-soluble = dissolve in water. Low SAA → prolonged molt with many deformed feathers and lower body mass. They must derive these fatty acids from linoleic and linolenic acids in the diet.EXAMPLE: Murphy and King (1987) studied molting White-crowned Sparrows • Molt requires high levels of sulfur-containing amino acids (SAA. . the latter is essential) due to deposition of large amounts of cysteine in keratin of feathers. etc. Choice → preferentially consumed high SAA diet and had normal molt.microbial synthesis/degradation. 3) Vitamins = organic substances that cannot be synthesized by the animal but are required in low concentrations in the diet for normal metabolic function. . .

. Sulfur. Magnesium. 4) Minerals = inorganic elements needed in diet for a variety of functions. Potassium. a) Macro-Minerals = required in larger amounts. Phosphorus. serve a variety of functions in maintaining proper growth. Sodium. proper organ or tissue function. metabolic pathways. often involved in functional roles in enzyme operation. include Calcium.Several vitamins can be obtained via bacterial synthesis in animals with symbiotic digestive tract bacteria. TAKE HOME MESSAGE = Diet is more complicated than just providing enough energy. etc. or oxygen binding. . reproductive capacity.b) Lipid-soluble = soluble in fats. blood clotting. Chloride. at times animals may have to feed selectively on certain items regardless of their energy value in order to meet specific nutrient needs. b) Minor or Trace Minerals = very small amounts required.

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