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procedures involved in following, including assays of official drugs in I.P by non aqueous titration, Complexometric titration, gravimetric methods, diazotization titration, potentiometry, UV Visible method, HPLC & TLC UNIT III A detailed study on related substances and impurities present in drugs and their effect on drug stability and therapeutic action. ICH guidelines for impurities and related substances determination in drugs. UNIT IV Identification and quantitative determination of preservatives, antioxidants, coloring materials, emulsifiers, and stabilizers in pharmaceutical formulation.Quality control and in process quality control of tablets, capsules, liquid dosage forms, parentral and sterile preparations and ointments, creams, suppositories and contolled release products. UNIT V Quality control of containers and closures as per I.P, B.P, USP – Plastic containers, glass containers, rubber closures etc.Water analysis: Physical, chemical, and biological analysis of effluent COD & BOD.
PRACTICAL The practical syllabus comprises of the exercises based on the topics mentioned in the Theory syllabus. REFERENCE: 1. A.H. Beckett and J.B. Stenlake, Practical Pharmaceutical chemistry, psrt 1&2, the athlone press, London. 2. Pharmacopoeia of India, Govt. of India, Ministry of Health. 3. British Pharmacopoeia, ministry of health and social welfare, UK. 4. Textbook of Pharmaceutical chemistry by Bentley & Driver
Fundamentals of analytical chemistry 7th edition: skoog, west; holler.
6 Handbook of Microbiological Quality control, Stephen Denyer, W. B. Hugo, A. D. Russel, Norman A. Hodges, Sean P. Gorman,
Blackwell publishing, 2003.
COSMETIC ANALYSIS UNIT 1 Classification of raw materials and raw materials used in the cosmetic industry for the manufacture of finished products. Method of sampling, Indian Standard specification laid down for sampling and testing of various cosmetics in finished form by the bureau of Indian standards. Unit II
Isotopic dilution. lipstick and hair dyes. Beckett and J. Mendham. Unit V Standardization of cosmetics. Paul F. Basset. perfumes. Alan H. Larry N. 4. Tooth paste. Jeffery. depilatories. hair creams. after shave lotion. Mutnick. H. powders. bath and toiletries. Souney. skin powder. by) Vogels Text Book of Quantitative Chemical Analysis. 4th Edition. and Positron Emission Topography (PET). 3. Denny (Rev. Information on ingredients used in various cosmetics such as creams. Unit III General methods of analysis to determine quality of raw materials used in cosmetic industry. J. depilatories. Stenlake Practical Pharmaceutical Chemistry.Brief introduction of the following cosmetic preparation and a detailed study on their quality control: Shampoo. Part I and Part II. C. B. J. Toxicity tests for cosmetics Unit IV Radiochemical Analysis . lipstick. 4th Edition by Leon Shargel / Andrew B. 2.C. 5th Edition 1989. ICH guidelines for stability studies of formulation. A. REFERENCE: 1. ELBS.. Comprehensive Pharmacy Review 5th Edition by Leon Shargel. . H. skin creams.Stability testing of cosmetic formulation and shelf life prediction. Sawnson – 2004. Yu – 1999.Instruments used .analytical and screening instruments. toiletries etc. neutron activation. hair products nail polishes. lotions. and their analysis. nail polish. R. G. Applied Biopharmaceutics and Pharmacokinetics.
9. Practical HPLC method development by Lloyd R. UNIT – III . 3rd Edition . John Wiley and Sons 2nd Edition – 1997 INSTRUMENTAL ANALYSIS UNIT – I Uv visible spectrophotometry – Brief review of electromagnetic spectrum and absorption of radiations. J. molecular ion and metastable peak. Joseph J. Indian Pharmacopoeia. I and Vol. Mc lafferty rearrangement.1997. 6. II . spectral correlation with structure. Vol. UNIT – II Flame photometry and atomic absorption spectrophotometer. ICH guideline for impurity determination and stability studies. electron and chemical ionization modes. energy levels and selection rules.D. influence of substituent. Quantitative Analysis of Drugs in Pharmaceutical Formulations. application of spectrophotometry inqualitytative and quantitative analysis. application. stereo chemical effect. Mass spectrophotometry. New Delhi. Beer and lambert’s law limitations of the law. Longman Scientific and Technical Publishers. 8. Wilkinson and R. Govt. 7. solvent effect. Glajch.1996. fragmentation patterns nitrogen and ring rules. Sethi. ring size and strain on spectral characteristics.5. Feieser kuhn and nelson rules. Kirkland. of India. B. The Controller of Publications. Joseph I. Theory. P. Moore : Herry’s Cosmeticology. Non conjugated interactions. wood ward Fieser. Snyder. J. Singapore.
quadrupole broadening and decoupling. Spin – spin splitting. classification and of Flash chromatographic. diasteromeric protons. PRACTICAL The practical syllabus comprises of the exercises based on the topics mentioned in the Theory syllabus. A. 4th Edition • Textbook of Pharmaceutical chemistry by Bentley & Driver . H. Pascal’s triangle. Over Pressure counter Layer – Chromatography. techniques. double resonance. size exclusion an dion pair chromatography Practical Pharmaceutical Chemistry. High Pressure Liquid Chromatographpy. UNIT – IV Chromatography. of conformations and stereochemistry on the spectrum. Stenlake Part I and Part II. chromatography. High pressure Thin Layaer chromatography. mechanism of coupling. bonded phase. Bay effects. spin decoupling. REFERNCES • Vogel Text Book of Quantitative Chemical Analysis. Vaccum Liquid Chromatography. shift reagents – mechanism of action. Longman. Peri. Centrifugal affinity chromatography. B. effect. long range coupling – Epi. virtual coupling. London • current chromatography. Beckett and J. separation mechanisms General – principleas. UNIT – V TLC. Coupling constant. normal and reversed phase. chemical shift and shielding and magnetic anisotropy. column chromatography chromatography.Nuclear Magnetic Resonance Spectrometry: Magnetic nuclei.
Conformational isomerism . west.A. clinical trials. • Instrumental methods of Analysis. New york ADVANCED PHARMACEUTICAL CHEMISTRY UNIT – I General strategies for drug development: Biology of disease.A. development of lead structures.J. Z nomenclature to label geometrical isomers. Meritt.g. D. H. Optical isomerism . Skoog and leary J.importance of geometrical isomerism to drug action. J. Fischer and Newman projections) to represent organic molecules.A. use the E. understand the concepts of optical activity and optical purity.importance of optical isomerism to drug action.H. S configurations to label optical isomers. Saunders college publishing . Dean and F..different conformations of alkanes and . chemistry and lead identification. holler. UNIT – II Historical development of pharmaceutical chemistry Sources of new drugs Drug nomenclature Structural factors affecting biological activity Physicochemical properties in relation to biological activity UNIT – III Molecular stereochemistry: Geometrical isomerism . Settle Wadsworath . New york. use stereochemical projections (e.• • Fundamentals of analytical chemistry 7th edition: skoog. understand the terms enantiomers. L. diastereomers and meso compounds. Principles of instrumental analysis. use R. Willard.L.
British Pharmacopoeia. Royal Society of Pharmaceutical Press. 2. pharmacokinetic andbiopharmaceutical aspects.. UNIT-V Quantitative analysis of structure activity:Relationship History and development of QSAR. Stationary Press. relationship between them.. Physicochemical parameters. Drug receptor interactions.Hansch analysis. BCCT. Pakistan. London. distribution.Introduction.. University of Karachi. transdermal absorption. understand the energy barriers to rotation and interconversion among conformational isomers UNIT-IV PRODRUG DESIGN. gastro intestinal absorption. Manual of Qualitative Organic Analysis. Arayne M. Karachi. chemical bond. rationale of prodrug design and practical considerations. Saeed. PRACTICAL The practical syllabus comprises of the exercises based on the topics mentioned in the Theory syllabus. Fee Wilson analysis. 3D QSAR approaches. . REFERENCE: 1. Statistical methods – regression analysis. parenteraladministration. partial least square analysis (PLS) and other multivariate statistical methods.cycloalkanes.
applications of IR Spectrometry in pharmacy. United State Pharmacopoeia. The chromophore concept. Lovis F. Health and Company. Applications of UV-Visible spectroscopy (qualitative and quantitative analysis). Mack Publishing Company. Vogel Text Book of Quantitative Chemical Analysis. United State Pharmacopoeial Convention. modern instrumentation – design and working principle. Experiments in Inorganic Chemistry. Inc. Woodward – Fischer rules for calculating absorption maximum. Eston. 6. Boston. Modern Pharmaceutical Analytical Techniques – Theory UNIT – 1 UV-VISIBLE SPECTROSCOPY : Brief review of electromagnetic spectrum and absorption of radiations. instrumentation and its application. absorption by organic molecules. Fiesev D. USA. FTIR – theory. Remington Practical of the Science and Pharmacy. Theory of electronic spectroscopy. molecular vibration. Twinbrook Parkway. London. Unit – II SPECTROFLUORIMETRY: .. choice of solvent and solvent effects.D. IR – Spectrometry: Theory.C. Pennsylvania. 5. 12601. Rockyville M. 4.3. absorption law and limitations. Longman. sample preparation. 20852 USA. instrumentation.
NOESY. C13 NMR-Introduction. Mass spectrometry: Theory. ionization techniques. coupling constant. interpretation of spectra. comparison of fluorescence and UV-Visible absorption methods and applications in Pharmacy. electron bombaratment. UNIT – 4 CHROMATOGRAPHIC TECHNIQUES . factors affecting fluorescence intensity. C13 NMR Spectra and its structural applications. solvents. fast atom bombardment and application of mass spectrometry. COSY and applications in Pharmacy. Instrumentation. instrumentation. relationship of chemical structure to fluorescence spectra. chemical ionization. concentration effects. Interpretation of NMR spectra & applications of NMR spectrometry in pharmacy. and factors influencing the value of coupling constant.Theory. chemical shift. spin – spin coupling.SPECTROMETRY: Fundamental Principles and Theory. instrumentation. NOE. spin-spin coupling. effect of acids and bases on fluorescence Spectra. determination of molecular weight and molecular formula. Interpretation of mass spectra.Theory. Magnetic equivalence – spin – spin decoupling – shift reagents. UNIT-111 NMR . Natural abundance. and factors affecting chemical shift. chemical shift. 2D -NMR. Fragmentation pattern. proton exchange reactions. NMDR. spin-spin decoupling. advantages. solvent effect. FT-NMR. field desorption.
instrumentation. Pharmacy. instrumentation. interpretation of diffraction patterns and applications. PRACTICAL The practical syllabus comprises of the exercises based on the topics mentioned in the Theory syllabus. xray powder diffraction.a) Classification of chromatographic methods based on mechanism of separation: paper chromatography. instrumentation and application of atomic absorption and atomic emission spectroscopy. RP-HPLC. Bragg’s law. c) High Performance Liquid Chromatography: Principle. elution techniques and pharmaceutical applications. instrumentation. X – Ray diffraction methods: Introduction. generation of x – rays. ion exchange chromatography. solvents used elution techniques. LC-MS and applications in Pharmacy. b) Gas Chromatography: Theory and principle. derivatisation methods and applications in . column operation. thin layer chromatography. column chromatography and affinity chromatography – techniques and applications. UNIT – 5 Theory. x-ray diffraction. d) HPTLC and Super Critical Fluid Chromatography (SFC): Theory and Principle.
. Jain chemicak analysis. Srivastava. 5. New Delhi. Sharma. 2.H. R. Morphological. microscopical.K.H. Practical Pharmaceutical chemistry.K. Elementary organic absorption spectroscopy. J. Chand. Chand & . D. P. L.J. Nuclear Magneatic Resonance spectroscopy. 6. company Ltd. H. London. Dean and F.C. Skoog and leary J. Instrumental methods of Analysis. Y. New york. London. New Delhi. STANDARDIZATION AND STABILIZATION METHODS THEORY UNIT-I WHO guide lines of the standardization of Herbal raw materials and finished products. UNIT-II S. McGraw – Hill. Meritt.B. New york. Wadsworath . Introduction to molecular spectroscopy. Pitman.A.. Beckett and J. Saunders college publishing. Haris.REFERENCE 1.L. cytomorphological and chemical examinations of raw materials and finished products. the athlone press.H. Stenlake. s. Willard. A.A. London. A. Principles of instrumental analysis. Settle.A. 4. 3. psrt 1&2. 7.
Different types of additives used and analysis of these ingredients in ethical and non ethical foods. Physicochemical characterization in whole form.Microbial counts. pregnancy and diseases like diabetes. and in different conditions like normal. moisture content. bitterness values. lotions. lipstick. and their analysis. foreign matters. and physical constants applicable to the lipid containing drugs. Information on ingredients used in various cosmetics such as creams. alcohol content. volatile oil content. sex. Methods of stabilizations and Methods of stability testing. UNIT-V Factors affecting stability of a formulation.Determination of Physical and chemical constants such as extractive values. UNIT-III Standardization of food products. jaundice etc. depilatories. Concepts of nutritional requirements at different age. separation and identification of active principles. PRACTICAL The practical syllabus comprises of the exercises based on the topics mentioned in the Theory syllabus. UNIT-IV Standardization of cosmetics. ash values. toiletries etc. powders. . ICH guidelines. hair products nail polishes. Standardization of Herbal products. hypertension and atherosclerosis. excipients and their estimation by different techniques. Concept of development of stability indicating analytical methods. bioburden and Pharmacopoeial microbial assays.
Manufacturing and Quality control. 8th edition.Martin M. Suzanne Neilson.Vol-I & II . Vinitakale Kishor Bhusari.BOOKS RECOMMENDED 1. P Michael division publishing corporation 3. J.’ 10.P. 13. 8.s cosmeticology. The practical evaluation of phytopharmaceutical by brain & turner 17. Jemns T Cartenson.Sharma. 2nd edition. 14. 6. Borc 5. Beuty through Herbs. P. Pelezar/ Chan/ Kricg. Rieger. Drug stability. Method of protein analysis by istran kerese. 15. 16. Tortora. S. Indian herbal pharmacopoea. 5th edition. Cosmaceuticals Drug vs Cosmetics 7. “ Introduction to chemical analysis of foods.R. 12. 9. Antimicrobial in food. Herbal cosmetics. Applied Microbiology. 4.An introduction. 11. Jacobs. Michael J. Cosmetic analysis. Case. The chemical analysis of foods and food products. Urjita jain.Cosmetics Formulation. Taylor 2.Dr.selective methods and techniques by P. Morris B.. Funke. Food additive.Principles and Practices. WHO Guide line for the quality control of herbal plant material. “ Microbiology.” Microbiology”. Henry.Alfred larry branen. Marsel deckker.
Applications of polarography in pharmaceutical analysis. test procedures.P. GLC. P.P. B. Chlorzoxazone USP.P. Unit II: Raw materials: Establishment of specifications. P and U. stability.P. Regulator requirements. quality control. analgesics. Diclofenac Potassium B. Ibuprofen B. Niacinamide IP UNIT V Radiopharmaceuticals Basic properties.P Salbutamol Sulphate I. Acetysalicylic Acid B. Dicyclomine I. identification and quantitation of a natural drug substance by chromatographic methods such as TLC. Unit III Assay of pharmaceutical compounds (minimum10 compounds) based on spectrophotometric methods. clinical and medicinal applications of radioisotopes used in pharmacy and medicine preparations of diagnostic and therapeutic agents . A comparative study of the advanced physicochemical and chemical methods in analysis of drugs and pharmaceutical preparations as exemplified by vitamins. glycosides. Assay validation during product development phase..Dissolution.Semester Advanced Pharmaceutical Analysis Unit I Applications of optical and electrical instruments used in pharmaceutical analysis. Separation. S. Phenylpropanolamine Hcl B.P. sampling procedures.P Aminophylline Tablets I.II. antihistamines. identification and purity determination of the following important pharmaceutical compounds as mentioned in I. sulphonamides.P. Bioavailability evaluation of drugs and formulations. HPLC UNIT IV Preparation/synthesis. Methacarbamol USP. alkaloids. production. antibiotics.
M. and Brochmann Hanssen E . recovered materials and reprocessing. Eving QUALITY CONTROL AND QUALITY ASSURANCE Unit – 1 a. Conners K. Fundamental of Molecular Spectroscopy.A 2nd edition.Longman A Textbook of Pharmacy.Creaser C.S. Student and Pharmaceutical Chemistry. organization and accreditation bodies – ISO 9000.. b. E.G Churchill Livingston (1999).N. Organic Spectroscopy. I..Books for references: • • • • • • • • • • Vogel Text Book of Quantitative Chemical Analysis. Watson D.Golden W.Backet and Stenlake. Quality control laboratory: GLP.B. Instrumental Methods of Chemical Analysis. Practical Pharmaceutical Chemistry.M. Quantitative Chemical Analysis-Kolthof. ISO – 14000. sampling plan. -Banwell C. E.William Kemp. Sandell. Unit – II Philosophy of peer evaluation and accreditation. Analytical Application of Spectroscopy. and Davies A.C. distribution and distribution records – handling of returned goods.J.Higuchi T. A Textbook of Pharmaceutical Analysis.. Pharmaceutical Analysis.. NABL and OSHA (ISO 18000) Unit – III . US FDA guidelines for GLP in non clinical testing laboratories ( only salient features will be covered). Meehan..
validation of equipment and facilities in sterile and non sterile areas. sorption. Sandy Weinberg. 69. A guide to Total Quality Management – Kaushik Maitra and Sedhan K. Blister packs. chemical reactions. breakable seals and sealed tubes. How to practice GMPs – P. tape seals. REFERENCE: • • • • • • Quality Assurance Guide by Organisation of Pharmaceutical products of India. membrane filtration etc. Quality Assurance of Pharmaceuticals – A compendium of guidelines and related materials – Vol. biological tests. Types ofplastics used. reconciliation of labels. Vo. shrink handling. . permeation. P. Quality control of packaging material and filling equipment. coating.modification of plastics by drugs.Decker Series. Unit – V Packaging and labeling controls. Unit – IV a. b. film wrapper. training. I – WHO Publications. cartonsand other packaging material. 2nd Edition. Sharma. leaching. Bubble packs. cleaning validation. drying. hygiene. Good Laboratory Practice Regulations. Standard operating procedures for various operations like cleaning. types and tests assuring quality of glass. Organisation and personnel. responsibilities. foil / plastic pouches. disinfection. Different types of closures and closure liners. validation of air handling. bottle seals.Concepts of validation – types of validation. protocol for process validation.Ghosh. compression. filling. line clearance. sterilization.
identification and application of GLC. ORD and CD to structural studies of natural products. carbapenems and penems. MS. classification. hormones. pharmacology and medicinal uses of glycyrrhiza. G. e. cephalosporins. Steroids: Synthesis. Application of IR H1 NMR. Germacrone etc. thiamine. aloe. dried yeast. UNIT IV Glycosides: Introduction. linomycins and polypeptide antibiotics. vitamin B-Complex i. macrolides. Amino glycosides.• ISO 9000 and Total Quality Management – Sadhank. growth regulators. ruta etc. cascara. Ghosh. Alkaloids: Structure and synthesis of some important alkaloids. spectral properties configuration and reactions of steroids. UNIT III Terpenes: Chemistry of important terpenes from various group Humulene . rhubarb. cod liver oil. classification. dioscorea. biosynthesis of vitamins and discussion about halibut oil. biosynthesis of sterols. chemistry.e. extraction. senna. ginseng. penicillins. Mechanism of action. and Flavonoids. UNIT V Vitamins Introduction. CHEMISTRY OF NATURAL PRODUCTS UNIT I Isolation.g . isolation. β-lactamase inhibitors and other β-lactum agents. HPLC and counter current distribution to separation and analysis of plant constituents. UNIT II β – LACTUM AND NON –β LACTUM ANTIBIOTICS. nocardicins and monobactums.
Vyas and V.L.K. Phytochemistry Voi. Chemistry of natural products Vol I onwards IWPAC. A.P. Organic Chemistry of Natural Products Vol I and II by Gurdeep and Chatwall. Chapmannstall.Tracey. I to IV – Scikel Runeckles. D. Pharmaceutical Biotechnology by S.riboflavin. Gupta.Dixit. cyanocobalamine. E. I and II by Miller. Books for reference: • • • • • • • • • Modern methods of plant analysis – Peech and M. folic acid. Natural Product Chemistry “A laboratory guide” – Rapheal Khan. INTELLECTUAL PROPERTY RIGHTS AND REGULATORY AFFAIRS Unit – I . pentothenic acid. biotin.P.K. Recent advances in Phytochemistry Vol. Natural Product Chemistry Nakanishi Gggolo. Introduction to molecular Phytochemistry – CHJ Wells. Jan Nostrant Rein Hld. • • • • • • • Organic Chemistry of Natural Products Vol I and II by O. Agarwal. niacin and niacinamide. Finar Elements of Biotechnology by P. Biotechnology by Purohit and Mathoor. Organic Chemistry Vol I and II by I.V. Phytochemical methods of Harborne. vitamin C. Burger’s Medicinal Chemistry. and K. The Alkaloid Chemistry and Physiology by THF Manske.
Funding sources for commercialization of technology: Preparation of project report. publications of patents. echo responsibility – economic. Unit – IV Technology development / transfer/ commercialization related aspects. economic importance. Trade related investment measures (TRIM). Unit – II Trade related aspects of intellectual property rights. trade mark. TDB schemes. toxicological studies. HGT. social and environmental benefits of modern biotechnology. Unit – V a. Managing technology transfer – guidelines for research students. avoiding unethical practices. social responsibility. SOPs. TePP. Gazette of India. related registration and marketing issues.Need for the introduction of regulatory affairs in the pharmacy curriculum. Positive and negative aspects of IPP. Unit – III Nuts and bolts of patenting. filling of patent application. property protection and intellectual property rights. mechanism for protection of intellectual property – patent. copyrights. international patenting – requirements procedures and costs. Drug master file submission. status in Europe and US. World intellectual property organization. NRDC. drug related technology development. GOI schemes and incentives. concepts behind world trade organization (WTO). financial assistance for patenting. precautions before patenting disclosures / non disclosures. factors affecting choice of intellectual property protection. General Agreements on tariff and trade. b. role of intellectual property in pharmaceutical industry. business models. .
terpenes and flavonoids. saponins. microscopic and physical evaluation of the drugs. digitalis. john wiley. Bark: Cascara. pippermint. H. copy right. Stephen Elias. hyocyamus. Alkaloids. Rhizome: Ginger. steroids. 5th edition.Histological examination by section cutting: Transverse sections of fresh and crude drugs. UNIT III Preliminary Screening of Natural Products:Preliminary chemical tests for the detection of carbohydrates. copyright and trademark. The WTO and India’s Pharmaceutical industry – paten protection. Rheum. sophistication and substitution. Nolo publishers. Stem: Ephedra. UNIT II Powdered drug examination: Cinnamon bark. nux vomica seeds. Jackson Knight. Wagner's reagent test. 2003. Flower: clove flower bud. oxford university press EVALUATION OF CRUDE DRUGS UNIT 1 Crude drugs. coriander. official and non-official drugs. spoilage. David Liwelyn. inferiority. Termeric. 2006.Books for reference: • • • • • Patent. . Patent. glycosides. Nolo. Seed: Castor. 20001 Intellectual property: patents. Fruit: piper. tannins. cinnamon. admixture. Belladonna Glycyrrhiza and Rauwolfia. fennel. Sweet and Maxwell. Leaf: senna. copyright & trademark: An Intellectual property desk reference. Evaluation and Adulteration of Drugs The organoleptic. datura and catharenthus. clove flower bud. eucalyptus. Types of adulteration. chemical and therapeutic classification. trade marks and allied rights. Rodolph Cornish. TRIPS and developing countries. alkaloids. 2004 Patent strategy: for researchers and research managers. Root: Aconite. senna leaf. Richard Stim. . coriander. Raichard stim. Mayer's reagent test. atropa. commerce and preparation of drugs. sudip chaudhuri.
Plant Drug Analysis 2nd edn: Springer. • • Harbone J. rauwolfia. Sterols. Reference Books • Wagener H. castor.Assay of benzoin.Assay of pepermint oil for total esters.Isolation of menthol from Mentha piperita. UNIT V Identification of fixed oil by colour reactions.Dragendorff's reagent test. . lead acetate test UNIT IV Phytochemical Examination of Natural Products Leaves:digitalis. Flavonoids. Fruits and Seeds: Clove. Roots: belladonna. Extraction of Natural Products Using Near Critical Solvents (1993).B. 5. Kedde reagent test. Leibermann-Burchard test. • 6.. eucalyptus. Phytochemical Methods (1998).A. Salkoawaski test.Saponification value of cotton seed oil. Bell. Meyer.. datura. haemolysis test. Saponins. F. Rhizome: Podophyllum. • • 4. Keller killiani test.To determine the acid value of rosin. atropa. senna. Stem: Senna. B.R. froth test. Practical High Performance Liquid Chromatography (1999). Laboratory hand book for the fractionation of natural products (1998).V.Tannins.J. ferric chlorides test. Harlwood B. . King M. V. fennel. coriander. Sanguineria. Hughton P.Colour reactions of tannins. Barks: Cascara.Isolation of shikimic acid from Illicium anisatum. cyanidin test. Glycosides. Encyclopedia of Plant physiology Secondary Plant Products (1980).Determination of volatile oil in Cinnamon. cinnamomum. and Bott T. and Bladt S. Berlin (1996). colour test.Iodine value of olive oil.
Unit – 5 . Probability. sampling techniques.sign test.H. 1-3 (1985). statistical procedures in assay development. Measurement of spread of data.. E. • • • Pellwtier S.E.W. dose – effect’s relationships. process control. Stumpt P. Alkaloids Vol. schwhart control charts. definition and probability distributions. ANOVA (one way). Biosynthesis of Plant Sterols and other Triterperoids (1981). Unit – 2 a. The Biochemistry of Plants Secondary Plant Products (1981). • Goodwin T. Wilcoxon signed rank test. Measures describing the center of data distributions.W. Linear regression and correlation. contingency tables. Chi squared test. Unit – 4 Bio assay. Hypothesis testing – t tests. Probability. significance of correlation and regression.F. Biosynthesis of Indole Alkaloids (1983). New York (19551977). calculation of LD50 & ED50. F tests. Unit – 3 The population – the sample.U. Statistical inference – statistical estimation. normal and binomial distributions and their significance b.V-XVI Academic Press. and Basha A. and Conn. Rahman A. statistical quality control. BIOSTATISTICS & COMPUTER APPLICATIONS Unit – 1 An introduction to statistics.K. Runs test for randomness.• Manske R. precision and accuracy. The Alkaloids Vol.
CDROM. software opearating system. Prentice – hall of India. 3rd edition. Drug and pharmaceutical series volume – 80. Amsterdam. hardware. 2003. Richard. DBMS.a. Dochain. 2002 . D. J. b.2000 Pharmaceuticals statistics by Sunford Bolton. REFERENCE • • • • • An introduction to Biostatistics : A manual for students in health sciences.S. Elsevier. concepts. Internet.S. Programming in Ansi C. Fundamentals of computers. Marcel Dekker Inc. basic units and functions. Application of computers in pharmacy.. steps involved in software development. Computer application in Pharmaceutical Research and Development Computer application in Bio technology. P. 2nd edition by E. Balaguruswamy. Sundar Rao. foxpro. C languages & programming.
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