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Drug Study 01

Drug Study 01

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Published by Jm Mapula

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Published by: Jm Mapula on Jan 22, 2012
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BRANDNAME Thorazine (zycloran


GENERIC NAME Chlorpromazine

DRUG CLASS Antipsychotics


INDICATION Acute and chronic psychoses, particularly when accompanied by increased psychomotor activity. Nausea and vomiting. Also used in the treatment of intractable hiccups.



Assess mental status prior to and periodically during therapy. Monitor BP and pulse prior to and frequently during the period of dosage adjustment. May cause QT interval changes on ECG. Observe patient carefully when administering medication, to ensure that medication is actually taken and not hoarded. Monitor I&O ratios and daily eight. Assess patient for signs and symptoms of dehydration. Monitor for development of neuroleptic malignant syndrome (fever, respiratory distress, tachycardia, seizures,

Block dopamine receptors in the brain; also alter dopamine release and turnover. Prevention of seizures

CNS: neuroleptic malignant syndrome, sedation, extrapyramidal reactions, tardive dyskinesia CV: hypotension (increased with IM, IV) EENT: blurred vision, dry eyes, lens opacities GI: constipation, dry mouth, anorexia, hepatitis, ileus GU: urinary retention Hematologic: agranulocytosis, leukopenia Skin: photosensitivity, pigment changes, rashes

Hypersensitivity. Cross-sensitivity may exist among phenothiazines. Should not be used in narrowangle glaucoma. Should not be used in patients who have CNS depression.

long-term use to prevent relapse and sustain symptom improvement Contraindicated with hypersensitivity to sertraline. pregnancy Physical: Weight. anxiety. drowsiness. elevated liver function tests. liver evaluation. fatigue CV:Hot flashes. pruritus. pregnancy CNS: Headache. severe muscle stiffness. vision changes. Zoloft Setraline Hydrochloride Anti-depressant Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin. P. contact dermatitis GI: Nausea. hypertension or hypotension. bowel sounds. elevated CPK. affect. lesions. T.sedation. lactation. rash.diaphoresis.vomiti History: Hypersen sitivity to sertraline. insomnia. peripheral perfusion. seizures. skin rash. tiredness. Report symptoms immediately. and alpha1-adrenergic or dopaminergic receptors. palpitations. urinary output. abnormal gait. agitation. renal and liver function tests . histaminergic. Treatment of major depressive disorder Treatment of obsessivecompulsive disorders (OCD) Treatment of panic disorder with or without agoraphobia Treatment of posttraumatic stress disorder. diz ziness. impaired hepatic or renal function. blocks uptakeof serotonin with little effect on norepinephrine. acne. May also cause leukocytosis. nervousness. lactation. light-headedness. reflexes. tremor. pallor. chest pain Dermatologic:Swe at ing. Use cautiously with impaired hepatic or renal function. loss of bladder control. muscarinic.

dry mouth. cough. diarrhea. bronchitis. gingivitis GU: Painful menstruation. dyspepsia. sexu al dysfunction.rhinit is . dysphagia. gastroenteritis. frequency. urgency.Treatment of premenstrual dysphoric disorder (PMDD) Treatment of social anxiety disorder (social phobia) ng. impotence. taste changes. constipation. pharyngitis. cystitis. vaginitis Respiratory: Uppe r respiratory infections. anorexia. dyspnea. flatulence.

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