Drug Card: Sulfazine Classification: Sulfonamide derivative with anti-inflammatory action Name of Drug (Generic & Brand) Classification

Sulfasalazine, Sulfazine, Anti-infective__ Clients Dosage _500 mg tab p.o. bid (9 a.m., 9 p.m.) _______ Usual Dose Range- 500 mg to 1 g (delayed-release) P.O. daily for 1 week; then increase by 500 mg/day P.O. q week up to 2 g/day in two divided doses. Onset/Peak/Duration: PO- Onset: 1.5 hours, Peak: 10 hour, Duration: Unknown

Indications for use: _Osteoporosis, Pagets Disease Indications specific to use in your clients: _ Osteoporosis Nursing Assessments/Responsibilities:
- Monitor CBC with white cell differential. Watch for evidence of blood dyscrasias. -Stay alert for signs of erythema multiforme. Report early signs before condition can progress to StevensJohnson syndrome. • Monitor patient for signs and symptoms of superinfection, including fever, tachycardia, and chills. - Monitor liver function tests; watch for signs and symptoms of hepatitis. -Check kidney function tests weekly. Evaluate patient's fluid intake, urine output, and urine pH. • Monitor neurologic status. Report seizures, hallucinations, or depression.

exfoliative dermatitis. local irritation. depression. fatigue. anorexia. apathy. tinnitus. nausea. hepatitis. pancreatitis. erythema multiforme. peripheral neuropathy. photosensitivity reaction. orange-yellow skin discoloration. orange-yellow urine. chills. generalized skin eruption. lupuslike syndrome . renal failure. proteinuria. ataxia. anxiety. hallucinations. agranulocytosis.• If patient takes drug for rheumatoid arthritis. pulmonary infiltrates. transient myopia. fibrosing alveolitis. crystalluria. shortness of breath. hematuria. insomnia. stomatitis. reversible immunoglobulin suppression. leukopenia. periorbital edema. seizures. drowsiness. thrombocytopenia. alopecia. pleuritis. vomiting. megaloblastic anemia. allergic pneumonitis. monitor therapeutic response 4 to 12 weeks after therapy begins Side Effects:headache. jaundice. reversible oligospermia. pruritus. epidermal necrolysis. hemolytic anemia. polyneuritis. allergic myocarditis or pericarditis. serum sickness. abdominal pain. aplastic anemia. pseudomembranous colitis. vertigo. urticaria. hypersensitivity reactions including anaphylaxis. dry mouth. toxic nephrosis with oliguria and anuria. optic neuritis. glossitis. drug fever. cyanosis. Stevens-Johnson syndrome. hepatocellular necrosis.