DRUG STUDY Drug Coamoxiclav Action Inhibits enzymes involved information of peptidoglycan layer of bacterial cell wall No effect

on human cell walls Bactericidal; only works ondividing bacteria Well absorbed enterally Clavulanic acid inhibits bacterialß-lactamase Indications Lower resp tract infections, otitis media, sinusitis, skin & soft tissue infections, UTI, pre& postsurgical procedures, bone & joint, O & Gi nfections, dental infections Dosage 625mg/tab q8 Contraindications Adverse Effects Allergic reactionsitching, rashes, fever – angio neurotic edema- anaphylaxis (1 in 50,000to 100,000)Crossallergy with other penicillins Partial cross-allergy withcephalosporins (10%) Hepatitis, cholestatic jaundice Erythema multiforme (including StevensJohnson) Toxic epidermalnecrolysis; exfoliativ edermatitis Diarrhea, vomiting Rashes Neutropenia Anaemia. Nursing Considerations History of hypersensitivity Renal impairment Hepatic impairment – may cause cholestatic jaundice up to 6 weeks after cessation May cause macula papular rashes almost always in presence of glandular fever

History of penicillin hypersensitivity. Super infections involving Pseudomonas or candida.

Paracetamol

Inhibits the synthesis of prostaglandins that may serve as mediators of pain and fever, primarily in the CNS

For mild fever

500mg/tab PRN

Hypersensitivity to acetaminophen or phenacetin; use with alcohol

Side effects are rare with paracetamol when it is taken at the recommended doses. Skin rashes, blood disorders and acute inflammation of the pancreas have occasionally

BEFORE: ~ Advise parents or caregivers to checkconcentration s of liquidpreparations. Errorshave resulted in serious liver damage.~ Assess

potential Side effects of aspirin and NSAIDs.5°C (103°F) or lastslonger than 3 days . AFTER: ~ Advise patient to consulthealth care professionalif discomfort or fever isnot relieved by routinedoses of this drug or if fever is greater than39.occurred in people taking the drug on a regular basis for a long time. One advantage of paracetamol over aspirin and NSAIDs is that it doesn't irritate the stomach or causing it to bleed. DURING: ~ Adults should not take acetaminophen longer than 10 days and children not longer than5 days unless directed by health care professional. tachycardia.~ Advise mother or caregiver to take medicationexactly as directed andnot to take more thanthe recommendedamo unt. fever. andmalaise). note presence of associated signs (diaphoresis.