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SYNTHESIS OF NANOSIZED HYDROXYAPATITE BY ELECTROCHEMICAL METHOD AS BONE AND TEETH BIOIMPLANT

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: Desi Liah Martasari (2308 100 017) Desy Nurwijayanti (2308 100 113) Department : Chemical Engineering FTI-ITS Advisor : Prof. Dr. Ir. Heru Setyawan, M. Eng Abstract Nanocrystalline hydroxyapetite based bioceramics are the new concern in biomaterials research. The main driving force behind the use of hydroxyapetite as bone substitute materials is their chemical similarity to the mineral component of mammalian bones and teeth. As a result, in addition to being non-toxic, biocompatible, not recognized as foreign materials in the body and most importantly both exhibit bioactive behaviour and integrate into living tissue by the same process active in remodelling healthy bone. Therefore, application and prospective use of the nanosized and nanocrystalline hydroxyapetite for a clinical repair of damaged bones and teeth are also well known. Thus, the nanosized and nanocrystalline forms of hydroxyapetite have great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. The purpose of this research is to synthesize nanosize hydroxyapetite by an electrochemical method using direct current and to determine the right condition (current density, duration of electrolysis, the distance between two electrodes, electrolysis temperature, pH and electrolyte concentration) to produce desirable characteristic of hydroxyapetite. This synthesis will be started by diluting Na2H2EDTA.2H2O, KH2PO4 and CaCl2 at concentration Ca/EDTA/PO43- 0,25/0,25/0,15 M then it will be electrolized by using direct curent based on variabel choosed before. From this process,it will produce deposit. Next, aging then filter and wash with demineralized water to eliminate impurities. After that dried in the certain temperature. The dried particles were characterized for their crystal structure by XRD, the size by BET method, their functional groups by FTIR test, their stability against heating by TG-DTA test Key word: electrochemical method, nanosize, hydroxyapetite, synthesis, characterization