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Abstract: 12281

A19 - Host genetic factors of pathogenesis 11 A19

Identification of the CCR5Δ32 and T303A CCR5 gene polymorphisms in Mayan and Mestizo
populations of Yucatan, Mexico

N.R. Pavia, I. Quintal, N. Valadez, R.A. Gongora, L.G. Salomon, D. Lara

Universidad Autonoma de Yucatan, Centro de Investigaciones Regionales 'Dr Hideyo Noguchi', Merida, Mexico

Background: Among the CCR5 polymorphisms, the CCR5Δ32, T303A and 893delC cause premature translation termination.
CCR5Δ32 polymorphism has been associated to cancer, diabetes, HIV infection and AIDS progression. T303A polymorphism
has been associated to susceptibility to HIV infection. The frequency of these polymorphism varies regarding ethnic and
population group studied. The frequency of these polymorphisms is unknown in Mayan and Mestizo populations of Yucatan
Methods: The aim of this study was to determine the frequency of CCR5Δ3 and T303A CCR5 gene polymorphisms in Mayan
and Mestizo populations from Yucatan, Mexico. We analyzed 280 samples, 140 of Mayan and 140 of Mestizo population.
Genotypes were identified by PCR from DNA extracted from peripheral blood with primers: CCR5 R y CCR5 F for CCR5Δ32
and F2 - R2 for T303A.
Results: Heterozygous genotype of CCR5w/CCR5  Δ32 was found in 9.28% of Maya population and 0.72% of Mestizo
population, the remaining samples were wild type genotype. For the T303A polymorphism, the heterozygous genotype was
found in 5% of Mestizo population and the wild type genotype TT was present in 100% of Mayan and in 95% of Mestizo
Conclusions: Polymorphism CCR5 Δ32 is present in Mayan and Mestizo population of Yucatán. Polymorphism T303A of
CCR5 gene was found only in Mestizo population of Yucatán.

Country(ies) of Research: Mexico
Presenter: Ms. Doctor Norma Rosario Pavia, Universidad Autonoma de Yucatan, Merida [Mexico]