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Predisposing Factors: Genetics, Age, Gender, Race production of catecholamine Angiotensin Sodium and Water Retention

(Epinephrine & Norepinephrine)

Precipitating Factors: Stress, Obesity, Nutrients, Substance abuse, DM, Kidney Disorder Insulin resistance Glucose Vascular changes Blood Volume Atherosclerosis

Hypertension

Heart

Kidney

Brain

Eyes

Arterial vessels of lower extremities

Chest pain

Urine output

Mayocardial ischemia, MI

Chronic Kidney Disease

Head ache, dizziness, fatigue, changes in mentation, sensorium and neurologic status

Blurring of vision, double vision, and other visual anomalies

Claudication, painful sensation,

Gangrene Stroke, Transient ischemic attack, Acute brain infarction, Cerebral thrombosis, aneurysm Retinal Vascular sclerosis, Loss of Vision

DEATH