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Pharmaceutics - I
INTRODUCTION TO AROMATIC WATERS
Aromatic waters are clear aqueous solution saturated with volatile Oils (e.g. rose oil, Peppermint oil, or other aromatic or volatile substances eg. camphor. Their odours and taste are of those of the drugs or volatile substances from which they are prepared. Aromatic waters may be used for perfuming, ﬂavoring or for special purposes for eg. 1. 2. Camphor water has been used as the vehicle in ophthalmic solutions owning to its ability to contribute refreshing, stimulating effect to the preparation. Hamamelis water known as witch hazel is employed as a rub, perfume and as an astringent in various cosmetic preparations, particularly in after-shave lotions.
The distillation method involves the placing of the coarsely ground odoriferous portion of the plant or drug from which the aromatic water is to be prepared in a suitable still, with sufﬁcient puriﬁed water. Most of the volume of water is then distilled. The excess oils collected with the distillate rises to the top of the aqueous product and are removed. The remaining aqueous solutions, saturated with volatile material require clariﬁcation by ﬁltration.
Aromatic water is prepared by intermittently shaking 2ml (if liquid) or 2gm (if solid) of the volatile substance with 1000ml of puriﬁed water in suitable container for period of 15 minutes. After the period of agitation the mixture is set aside for 12 hours or longer to permit the excess oil and the solid substance to settle. Without further agitation the mixture is passed through a wetted ﬁlter paper and puriﬁed water added as needed to bring the volume of the ﬁltrate upto the prescribed quantity.
MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
The resulting slurry is thoroughly agitated several times for the period of 30 minutes and then ﬁltered. Therefore 50gms of talc is added for 1000ml of preparation which acts as a distributing agent. Preparation of concentrated Aromatic water: These products are alcoholic non aqueous preparations containing 2% of volatile oils They are forty times stronger than the ordinary aromatic waters. Alternative solution Method: By this method the volatile oil or suitably comminuted aromatic solid is thoroughly incorporated with 15gms of talc and to this mixture is added 1000ml of puriﬁed water. separating as an oily layer.Pharmaceutics . light resistance container.I Experiment No. Hence when a solution of the oil in 90% alcohol is diluted with a limited amount of water the aromatic portion of the oil remains in solution while the non-aromatic portion is precipitated off. Storage: Aromatic water deteoriate with time and it should be made in small quantities and protected from intense light and excessive heat and stored in airtight. The aromatic portion is much more soluble in a weak alcohol than the non-aromatic portion. Note for teacher: Any other ofﬁcial aromatic water can be done beside the preparation given in the manual for these experiments MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION o 11 . The solution is agitated and set aside for a few hours and ﬁltered. Many volatile oils contain aromatic part and non-aromatic part. 3 3. and will absorbs the non-aromatic part.
Experiment No. Motor Skills: Skill for measurement of volume. 5. by Simple Solution Method.): Ingredients Quantity given Quantity taken (Factor x Quantity given) Use of ingredients 1.P. (Read the Introduction of Aromatic Waters.) Required quantity Factor = Quantity given 2. Volumetric Pipette (1ml). 4. evaluate and submit 100ml of Chloroform Water I.P. volumetric measurement New concepts: Proposition 1: Pharmaceutical Aid Preparation used as an excipient or base or vehicle for formulation of other pharmaceutical preparations.5 ml 1000ml = ……………………………………………………… 7. 6.0 Prior Concepts: Different types of solutions. Puriﬁed water I. 2. 3 1.I Experiment No. Volumetric Cylinder (100 ml).0 Formulation Table (As per I. 12 o MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION .) 2. Chloroform I. light resistant container.0 Apparatus: Glass Beaker (250 ml). 1.s. (q. Proposition 2: Proposition 3: Storage: Aromatic waters are stored in air tight.0 3.0 Learning objectives: Intellectual Skills: To understand the concept of solubility.0 Step wise procedure: It is saturated solution of chloroform in puriﬁed water .0 Title: To prepare. Measure the required quantity of chloroform.P.P.The solubility of chloroform is 1 in 800 parts of water. 3 Pharmaceutics .
P. (Question numbers to be allotted by the teacher. State the solubility of Chloroform in water. Classify Aromatic waters on the basis of there strength.. 4. 8.Pharmaceutics . Deﬁne Pharmaceutical Aids. . 3 2. Add sufﬁcient quantity of puriﬁed water to make the required volume with constant stirring so that chloroform gets uniformly mixed.0 Questions : Answer Q. preparation is submitted in …………………………………………….. ….I Experiment No. container with neat label.….0 Observation and evaluation: Name of the Preparation Test Description Chloroform water I.) 1. What is the concentration of chloroform in chloroform water? 7. 3.0 Labeling of formulation: (Students shall write all aspects of labeling in the space provided below. Q.. Dose: 15 to 30 ml Category: Pharmaceutical Aid. Q. 11. .. Write storage conditions for chloroform water with their signiﬁcance? 6. .) 9. 5.….…... Colour Odour Speciﬁcation Clear Colourless Aromatic Observations 10.. Q.. What are Aromatic waters? 2.0 Result: …………ml of …………………………………………………………………………. Storage: store in airtight container in cool place away from light... State expiry date that you will mention for chloroform water? MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION o 13 .
Experiment No. 3 Pharmaceutics .I (Space for answers) 14 o MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION .