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Dr.

Niranjan Murthy H L
Asst. Prof., Dept. of Physiology
Sree Siddhartha Medical College & Hospital, Tumkur
SARCOTUBULAR SYSTEM

T-tubule- inward extension of sarcolemma


opens to exterior
contain ECF
run transverse to myofibrils
transmit action potential
L-tubule- sarcoplasmic reticulum
run parallel to myofibrils
terminate in terminal cisternae
stores calcium ions
Triads- two terminal cisternae abutting a t-tubule
Action potential

Neuromuscular transmission

End plate potential

Muscle Action potential


Propagation of muscle AP
along sarcolemma

AP reaches triad
via T-tubule

Depolarisation
of T-tubule

Dihydropyridine receptor acts as voltage


sensor
Opening of ryanodine receptors

Ca2+ influx from


Sarcoplasmic reticulum
Into cytoplasm

Binding of Ca2+ to Tn C

Conformational change in
troponin and tropomyosin
Exposure of binding sites on actin

Interaction of actin and myosin

contraction
Active pumping of
Ca2+ back into
sarcoplasmic reticulum

Tropomyosin covers binding sites of actin

relaxation