Oesophagus 7th edition

TNM definitions: AJCC = UICC
N0 Tis T1 Carcinoma in situ /High-grade dysplasia lamina propria or submucosa T1a lamina propria or muscularis mucosae T1b submucosa muscularis propria adventitia adjacent structures T4a pleura, pericardium, diaphragm, or adjacent peritoneum T4b other adjacent structures, e.g. aorta, vertebral body, trachea No regional lymph node metastasis N1 1 to 2 regional lymph nodes N2 3 to 6 N3 >6  [N1 was site dependent] M - Distant Metastasis M1 Distant metastasis  [M1a,b were site dependent]

T2 T3 T4

Changes from 6th edition

Anatomical Stage Groups (adeno & squamous) [UICC]
Stage IA Stage IB Stage IIA Stage IIB Stage IIIA Stage IIIB Stage IIIC Stage IV T1 T2 T3 T1, T2 T4a T3 T1, T2 T3 T4a T4b Any T Any T N0 N0 N0 N1 N0 N1 N2 N2 N1, N2 Any N N3 Any N M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M1

Oesophagus 7th edition

Major changes

Oesophageal Squamous Cell Carcinoma Prognostic Grouping
[AJCC adds type, grade & site]
T Stage IA 1 IB 1 2, 3 Stage IIA 2, 3 2, 3 Stage IIB 2, 3 1, 2 Stage IIIA 1,2 3 4a Low Stages: AJCC not all = UICC. N 0 0 0 0 0 0 1 1 0 M Grade Location 0 1,X Any 0 2,3 Any 0 1,X Lower 0 1,X Upper, middle 0 2,3 Lower 0 2,3 Upper, middle  0 Any Any 2 0 Any 0 Any Any 0 Any Any Stages IIIA,B, C & IV: AJCC=UICC

Oesophageal Adenocarcinoma Prognostic Grouping
[AJCC adds type & grade]
N 0 0 0 0 0 1 2 1 0 T Stage IA 1 Stage IB 1 2 Stage IIA 2 Stage IIB 3 (IIA) 1, 2 Stage IIIA 1, 2 3 4a Stage IIIB, IIIC, & IV… Low Stages: AJCC not all = UICC. AJCC=UICC M Grade 0 1, 2, X 0 3 0 1, 2, X 0 3 0 Any 0 Any 0 Any 0 Any 0 Any Stages IIIB, C & IV:

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