PT/aPTT vs BT/CT

Hemostasis: BV Injury Neural Tissue Factor Blood Vessel Constriction Platelet Activation Primary hemostatic plug Plt-Fusion Coagulation Activation Reduced Blood flow Thromibn. Fibrin Stable Hemostatic Plug .

Coagulation: Intrinsic 12.11.8 (aPTT-) Common Path (TT) FX  FXa Extrinsic-7 (PT) Prothrombin Thrombin Fibrinogen  Fibrin .9.

Clot formation & retraction Fibrinogen Thrombin Fibrin Mononer Fibrin Polymer F-XIIIa Cross Linked Fibrin .

 Ini dinamakan hemostasis primer .  Platelets segera membentuk plug hemostasis di tempat injuri.Proses hemostasis primer  Normal individu. koagulasi diinisiasi dlm 20 detik stlh injuri thd pembuluh darah yg menyebabkan kerusakan sel endotel.

.

.

 Platelet yg teraktivasi akan mengeluarkan substansi yg menstimulasi aktivasi platelet lbh byk dan mempengaruhi prosese hemostasis.Proses hemostasis sekunder  Hemostasis sekunder akan mengikuti— komponen plasma yg dinamakan respon faktor koagulasi (dlm complex cascade) yg membentuk fibrin yg akan memperkuat platelet plug. .

.

. Contact Activation pathway (Jalur intrinsik) 2.Coagulation cascade Coagulation cascade pada hemostasis sekunder mempunyai 2 jalur : 1. Tissue Factor pathway (Jalur ekstrinsik) yg membentuk formasi fibrin  Inisiasi koagulasi darah Tissue Factor pathway.

Prothrombin Xa Va Thrombin Fibrinogen Fibrin .

Extrinsic Pathway TF Prothrombin VIIa Xa Va Thrombin Fibrinogen Fibrin .

Intrinsic pathway XIIa Extrinsic Pathway XIa IXa VIIIa Prothrombin VIIa Xa Va Thrombin Fibrinogen Fibrin TF .

Intrinsic pathway XIIa Extrinsic Pathway XIa IXa VIIIa Prothrombin VIIa Xa Va Thrombin Soft clot TF Fibrinogen Fibrin XIIIa Hard clot Fibrin .

            I (fibrinogen II (prothrombin) V (proaccelerin. labile factor) VI VII (stable factor) VIII (antihemophilic factor) IX (Christmas factor) X (Stuart-Prower factor) XI (plasma thromboplastin antecedent) XII (Hageman factor) XIII (fibrin-stabilizing factor) von Willebrand factor .

.T – keduanya.Tes Hemostasis:  Screening tests: tests     BT .tes Platelet & fungsi pembuluh darah PT – ekstrinsik aPTT – intrinsik Thrombin.

Sign up to vote on this title
UsefulNot useful