Pathophysiology of Acute Glomerulonephritis

With the infections, an antigen-antibody complex forms that causes renal damage especially the nephrons. The damage to the nephrons allowthe passage of large molecules like the Red blood cell that causes hematuria and is the primary sign of Acute Glomerulonephritis. Another large molecule are the Proteins, that causes proteinuria. When proteinuria occurs, there is a decrese in the osmotic pressure that leads to generalized edema or anasarca. This decreases the circulating blood volume, which decreases the blood flow and affects the Renin-Angiotensin-Aldosterone-System, where the Renin promotes vasoconstriction that leads to hypertension.

Signs of Acute Glomerulonephritis
1. 2. 3. 4. 5. 6. 7. Hematuria Hypertension Generalized edema Proteinuria Oliguria Anorexia Nausea and vomiting

Diagnostic Test for Acute Glomerulonephritis
1. 2. 3. 4. Antistreptolysin-O (ASO) Titer. Urinalysis. Renal Biopsy. Is the most confirmatory diagnostic procedure. Increased BUN and Creatinine.

Management for Acute Glomerulonephritis
1. 2. 3. 4. Antibiotics. Antihypertensives. Bed rest. Increase oral fluid intake.

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