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2. Name 1 major pro-angiogenic factor and 1 major anti-angiogenic factormade in the body. 3. List 2 conditions in which therapeutic angiogenesis may be a benefit. What are the possible side effects?
4. What was the unexpected result that Judah Folkman often observed when he removed a patient’s primary tumor?
5. How did Folkman’s observation help to spark the idea of anti-angionesis as a therapy?
6. What type of substances are angiostatin and endostatin? Why is this important?
7. Why does anti-angiogenic therapies normally not attack normal vasculature? 8. Does anti-angiogenic therapy work as a single therapy? Explain.
9. Why does it seem that treating a cancer patient with an antiangiogenic therapy also assist in chemotherapy?
10. Explain how antiangiogenic therapy may actually prevent many cancers from developing.
11. Besides anti-VEGF based therapeutics, name 3 other possible ways we might try to inhibit angiogenesis. You can come up with ideas based upon the paper and the class notes.