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SEVILLANO DATE: JUNE 15, 2012 Generic/Trade Name Date Ordered Classification

Dosage and Frequency
PREPARATION • injectable solution

Mechanism of Action
• Furosemide is a potent diuretic (water pill) that is used to eliminate water and salt from the body. • It works by blocking the absorption of sodium, chloride, and water from the filtered fluid in the kidney tubules, causing a profound increase in the output of urine (diuresis). • The onset of action after oral administration is within one hour, and the diuresis lasts about 6-8 hours. • The onset of action after injection is five minutes and the duration of diuresis is two hours.


10mg/mL 30mg/mL • oral solution 10mg/mL 40mg/5mL • tablet 20mg 40mg 80mg

• Intravenous (IV) • Intramuscular (IM) • Oral ADULT: 10-40 mg PO bid 80-100 mg IM/IV q1-2h; give with saline

5-1 mg/kg IM/IV q8-24h 1-4 mg/kg PO qd .BID Infants and Children: 2 mg/kg IM/IV q6-12h 1-6 mg/kg PO q12-24h .PEDIATRIC Neonates (<28 days old): 0.

Nursing Responsibility PRECAUTIONS • caution if diabetes mellitus • caution if acute Myocardial infarction • caution if arrhythmias . drowsy.Indication • excessive accumulation of fluid and/or swelling (edema) of the body caused by heart failure. Contraindication • Hypersensitivity to sulfonamides • anuria • hepatic coma Adverse reaction SIDE EFFECTS • dry mouth. vomiting. nausea. • feeling weak. restless. thirst.

numbness. Therefore. and the nephrotic syndrome. • hearing loss • nausea. • caution if hearing impairment • caution if concurrent ototoxic agents • caution if SLE • caution if hepatic impairment • caution if severe renal disease • caution if urinary retention • caution if gout history • caution if pancreatitis hx • caution in gestational hypertension • caution in premature neonates • caution in elderly • caution if having/had iodinated contrast SPECIAL CONSIDERATIONS • The diuretic effect of furosemide can cause depletion of sodium. • jaundice (yellowing of the skin or eyes) • diarrhea. pain. careful medical supervision is necessary during treatment. blistering. body water and other minerals. stomach pain. clay-colored stools. burning. constipation. chloride. • it is sometimes used alone or in conjunction with other blood pressure pills to treat high blood pressure. chronic kidney failure. low fever. • electrolyte imbalances or light-headed • fast or uneven heartbeat • muscle pain or weakness • urinating less than usual or not at all • easy bruising or unusual bleeding • a red.cirrhosis. peeling skin rash. loss of appetite. or stomach pain • headache. dark urine. ADVERSE EFFECTS • severe hypokalemia • severe electrolyte imbalance • metabolic alkalosis • hypovolemia/dehydration • ototoxicity • thrombocytopenia . or tingly feeling • blurred vision.

• hemolytic anemia • aplastic anemia • leukopenia • agranulocytosis • anaphylaxis • vasculitis • interstitial nephritis • necrotizing angiitis • erythema multiforme • exfoliative dermatitis • Stevens-Johnson syndrome • toxic epidermal necrolysis • pancreatitis • cholestatic jaundice • SLE exacerbation • thrombosis • eosinophilia • rash with eosinophilia and systemic symptoms • generalized acute exanthematous pustulosis .