NAME OF DRUG Generic name: Vincristine sulfate Brand Name: Classification: Antineoplastic Agent Dosageand Frequency

:

ACTION the inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage.

INDICATION Vincristine sulfate injection is indicated in acute leukemia.

CONTRAINDICATION Contraindicated in pregnancy and lactation

ADVERSE EFFECTS Gastrointestinal – Constipation, abdominal cramps, weight loss, nausea, vomiting, oral ulceration, diarrhea, paralytic ileus, intestinal necrosis and/or perforation, and anorexia Cardiovascular – Hypertension and hypotension Loss of deep–tendon reflexes, foot drop, ataxia, and paralysis

NX RESPONSIBILITIES  Baseline data is obtained before starting vincristine Before using this medication, ask for medical history

Vincristine sulfate injection has also been Bronchospasm, Jaundice, shown to be useful in Marie tooth syndrome. combination with other oncolytic agents in Hodgkin’s disease, non– Hodgkin’s malignant lymphomas (lymphocytic, mixed cell, histiocytic, undifferentiated, nodular and diffuse types), rhabdomyosarcoma, neuroblastoma, and Wilms’ tumor.

Assess patients understanding of the chemotherapeutic agents and administration procedures Emphasize the importance of compliance by the patient with prescribed schedule • Avoid contact with the medication by transferring it from the bottle to a medicine cup and into the mouth. • Wear gloves when

contact with the medication cannot be avoided and when handling bodily fluids. .

ADVERSE EFFECTS gastrointestinal sympto ms: anorexia. during and after treatment Assess the clients condition including Most recent report of blood counts including hemoglobin.lethargy.The chemotherapy drugs prescription Before using this medication. vomiting. weakness. phlebitis. facial flushing. CONTRAINDICATION contraindicated in patients with thrombocytopenia.NAME OF DRUG ACTION INDICATION potent antineoplastic agent which has been shown to be useful in the treatment of carefully selected hospitalized patients with malignant tumors of the testis in whom successful treatment by surgery and/or radiation is impossible. white blood cells and platelets Assess patients understanding of the chemotherapeutic agents and administration procedures Inhibits RNA Generic name: plicamycin transcription and Brand Name: Mithracin Inhibits osteoclast response to parathyroid hormone Classification: Cytotoxic Chemotherapy Dosageand Frequency:    . NX RESPONSIBILITIES   Review. diarrhea. nausea.hemato crit. ther less frequently reported side effects include fever. coagu lation disorder or an increased susceptibility to bleeding due to other causes. should not be administered to any patient with impairment of bone marrow function. mala ise. treatment of certain symptomatic patien ts with hypercalcemia andhyp ercalciuria associated with a variety of advanced neoplasms. depressio n. headache. thrombocytopathy. ask for medical history Renal function should be monitored before. and skin rash. drowsiness. and stomatitis.

Neurotoxic side effects of chlorambucil may include such as myoclonus.The chemotherapy drugs prescription Before using this medication. ADVERSE EFFECTS Gastrointestinal side effects may occur including anorexia. or kidneys CONTRAINDICATION Chlorambucil is contraindicated in conditions like Thrombocytopenia. It is an antineopl astic andimmunosupp ressant and works by causing crosslinking of DNA. ask for medical history Emphasize the importance of compliance by the patient with prescribed schedule instructed the patient to drink plenty of fluids while taking this medication instructed the patient not to increase his dose or take the medication more often without his doctor's approval   . and cell death. joint s. agitation. NX RESPONSIBILITIES    Review. decreased cell division. and tonicclonic seizures. INDICATION        Lymphocytic leuke mia Lymphoma/lympho sarcoma Multiple myeloma Polycythemia vera Macroglobulinemia Ovarian adenocarci noma Immunemediated conditions affecting skin.NAME OF DRUG Generic name: chlorambucil Brand Name: Leukeran Classification: Dosageand Frequency: ACTION group of chemicals k nown asalkylating ag ents. Leukopenia. vomiting and/or diarrhea. muscular twitching. tremors. resul ting in altered protein production.

Hodgkin's disease. Intrathecal admin. malignant lymphoma. leucopenia (neutrophil <1500/mm3. • Wear gloves when contact with the medication cannot be avoided and when handling  .The chemotherapy drugs prescription Before using this medication. ADVERSE EFFECTS      pain or tenderness at injection site Hair loss Diarrhea occurs infrequently. thrombocytopenia. mouth sores and ulcers Nausea and vomiting rarely occurs. NX RESPONSIBILITIES   Review.NAME OF DRUG Generic name: Vindesine Brand Name: Eldisine Classification: Cytotoxic Chemotherapy Dosageand Frequency: ACTION binds to particular proteins and causes cell arrest or cell death. INDICATION For the treatment of acute leukaemia. acute erythraemia and acute panmyelosis CONTRAINDICATION pregnancy. lactation. ask for medical history   Emphasize the importance of compliance by the patient with prescribed schedule Emphasize the importance of compliance by the patient with prescribed schedule • Avoid contact with the medication by transferring it from the bottle to a medicine cup and into the mouth.

.bodily fluids.

• Wear gloves when contact with the medication cannot be avoided and when handling bodily fluids. chronic myelocytic or chronic lymphocytic leukemia. polycythemia vera. dryness. . Hair loss Mouth sores Darkening of veins used for infusion Redness. and bronchogenic carcinoma. ask for medical history instructed the patient to drink plenty of fluids while taking this medication Emphasize the importance of compliance by the patient with prescribed schedule • Avoid contact with the medication by transferring it from the bottle to a medicine cup and into the mouth. irritation with topical use NX RESPONSIBILITIES  Before using this medication. lymphosarcoma. mycosis fungoides. is a nitrogen analog of sulfur mustard INDICATION indicated for the palliative treatment of Hodgkin's disease (Stages III and IV).NAME OF DRUG Generic name: mechlorethamine Brand Name: MUSTARGEN Classification: Cytotoxic Chemotherapy Dosageand Frequency: ACTION an antineoplastic nitrogen mustard also known as HN2 hydrochloride.    . CONTRAINDICATION contraindicated in the presence of known infectious diseases and in patients who have had previous anaphylactic reactions to mustagen ADVERSE EFFECTS      Nausea and vomiting.

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