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Laboratory and Pilot Units Mixing, Drying, Granulating, Coating

Packaging Technology

2 | Laboratory and Pilot Units

Laboratory scale High-shear mixer granulator system Mixing, Granulating, Drying

When it comes to extremely homogeneous mixing results, granules of the highest quality and top production performance with short drying times, Hüttlin offers the right solution. With the Gentlewing bottom or top drive options, mixing and granulating enter new dimensions.
Gentlewing ▶ Maximum mixing quality with minimum mechanical stress on the product ▶ Minimal wall caking due to very close clearances between the product vessel and Gentlewing ▶ Excellent discharge due to the Z-design of the Gentlewing impeller ▶ Effective drying without tilting or microwave t echnology SmartFlow ▶ Highly-efficient gas distribution over 360° leads to better drying homogeneity ▶ Shorter drying times due to continuous, effective strip gas feeding Discharging ▶ The discharge valve design enables uninterrupted discharge, as the discharge velocity is not controlled by means of the valve, but by extremely low impeller speed

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Maintaining a leading position in process engineering Exceeding expectations with innovative solutions The Hüttlin high-shear mixer granulator with bottom drive is the best choice for typical granulation applications in combination with a fluid bed dryer. The top-drive version satisfies the highest of demands. UltraClean, SmartFlow, heating and vacuum unit with solvent recovery allows the HTG to extend up to a SinglePot unit or a high-containment unit. means enhancing the efficiency and economy of processes. This starts with the fluid bed and highshear mixer granulator systems for laboratory scale applications, which offer the equivalent performance and system features of our production sized equipment. Hüttlin continues this design similarity with the pilot-scale systems, thereby offering the best conditions for successful scale-up.

Gentlewing high-shear granulation technology

Bottom Drive

Top Drive

Z-shape impeller

Diskjet fluid bed technology

Diskjet

NexStep software

4 | Laboratory and Pilot Units

Mycromix – Batch sizes ranging from 0.1 to 3.5 kg*
▶ Bottom Drive ▶ Exchangeable container ▶ Gentlewing ▶ Chopper ▶ For organic processes – option

* at density 0.5 kg/l

The smallest high-shear mixer granulator with bottom drive and manual control system. The ideal solution for all laboratories in combination with the Mycrolab.
Length (mm) Width (mm) Height (mm) Electronic connection (kW) Mycromix Container volume (litres) 0.5 / 1.0 / 2.5 / 5.0 / 10.0 614 632 772 2.5

Technical specifications are subject to change without notice

Left: Exchangeable Mycromix container Right: Mycromix change mechanism

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Pilotmix – Batch sizes ranging from 3.5 to 60 kg*
▶ Top Drive, Bottom Drive ▶ UltraClean design – option ▶ SinglePot – option for Top Drive

* at density 0.5 kg/l

Top or bottom drive: You decide which drive concept best meets your requirements. Either as a small production unit or as a step between laboratory and production, this product line offers all advantages and features that are otherwise only available in
* at density 0.5 kg/l

production scale. This applies also to the new UltraClean CIP concept and the option of modular extension up to the SinglePot version. Another ideal feature is the inline solution with the Pilotlab as a dryer.

L1 L W

Left: Pilotmix T Right: Pilotmix B
H

H

W

L

25 Pilotmix Nominal size Total volume (litres) Electronic connection (kW) Ptot @ 50 Hz Length L1 (mm) Length L (up to wall; mm) Width W (mm) Height H1 (mm)** Height H (mm)** T 25 25 8 1,000 530 700 – 1,800 T 75 75 13 1,450 715 820 – 2,250

75 B T 100 100 13 – 1,450 1,100 2,200 2,540 1,500 740 820 – 2,450

100 B T 150 150 16 – 1,480 1,100 2,310 2,660 1,800 925 920 – 2,900

H1

150 B

– 1,710 1,300 2,450 2,900

** depending on discharge container respectively discharge unit; Technical specifications are subject to change without notice

6 | Laboratory and Pilot Units

SinglePot – Drying kept simple
The Hüttlin SinglePot high-shear mixer granulators combine all the advantages of the top-drive design with the specific features of SmartFlow, UltraClean, product heating and vacuum drying with solvent recovery system. This concept meets the highest demands regarding process times, process quality and handling. The Gentlewing along with the SmartFlow continuous strip gas feeding system replaces expensive, high-maintenance The wall installation enables true separation of the GMP and technical areas. All drives and supply lines can be serviced without having to enter the GMP area. Combined with the UltraClean concept, it provides a high-containment system which meets the very latest demands. accessories such as tilting options or microwave technology with short drying times.

1 2 3 4

Heated jacket Heated impeller shaft Heated lid SmartFlow, 360° strip gas feeding Discharge valve Gentlewing Chopper Temperature measurement Cleaning nozzles Filter Condensation unit Vacuum pump Video camera
4 5 6 7 2 8 9 9 11 12 10 13 3

5 6 7 8 9 10 11 12 13

1

SmartFlow: 360° strip gas feeding

UltraClean metal filter

SinglePot ▶ Excellent drying times without complicated concepts such as tilting or microwave technology ▶ Containment ready with only minimal additional features SmartFlow ▶ Highly efficient gas distribution over 360° for considerably higher drying homogeneity ▶ Shorter drying times due to continuous, effective strip gas feeding

Discharge valve ▶ The discharge valve design enables uninterrupted discharge, as the discharge velocity is not controlled by means of the valve opening, but by extremely low impeller speed UltraClean ▶ The first CIP concept, which significantly reduces cleaning times and ensures highest cleaning quality

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UltraClean – This is how CIP works
▶ Top Drive, Bottom Drive, SinglePot ▶ Metal filter ▶ CIP Cleaning CIP (Cleaning in Place) is only achieved in many of today’s systems at the price of extremely long cleaning times, mainly caused by the slow drainage of the cleaning medium through the fine metal filter mesh. With UltraClean, Hüttlin offers a concept, which significantly reduces cleaning times while ensuring perfect cleaning Combined with retractable cleaning system and the GMP-compliant design of all Hüttlin devices, the UltraClean version ensures fast and efficient CIP cleaning, which is also affordable. results. The newly developed metal filters with opening mechanism enable actual draining of the clean gas side and fast drying.

Product overview / dimensions
High-shear mixing and granulation technology Bottom Drive Lab Mycromix Top Drive Fluid bed technology Dryer, Granulator, Coater Solidlab 1 Solidlab 2

Pilot

Pilotmix 25T * Pilotmix 75T * Pilotlab S * Pilotlab L * Pilotmix 150T *

UltraClean

Pilotmix 25TUltraClean * Pilotmix 75TUltraClean * Pilotlab S * Pilotlab L * Pilotmix 150TUltraClean *

SinglePot SinglePot 25 SinglePot 75 SinglePot 150 SinglePot 25UltraClean SinglePot 75UltraClean SinglePot 150UltraClean

* Can be configured as a granulation line; Technical specifications are subject to change without notice

8 | Laboratory and Pilot Units

Customize your lab
With the modular Solidlab Technology you are able to run eight solid processes – just as you like.

Fluid bed systems Drying, Granulating, Coating

Only a technological leader creates innovative solutions The higher your requirements for drying, granulation and coating/layering are, the more you benefit from the Hüttlin fluid bed technology. The spraying system with the three-component nozzle generates homogeneous granules and excellent coating. The patented process gas distributor plate prevents adhesion of the product and offers the best conditions for reliable and reproducible processes.
Outlet air Combi Module Monobloc Inlet air

Basic Unit

Fluid bed
Diskjet ▶ Homogeneous airflow ensures optimum exchange of substance and energy, the tangential air outlet puts less strain on the filter system ▶ Best product mixing results due to controlled and uniform process air distribution ▶ Process times can be significantly reduced Dynamic filter ▶ Continuous filter cleaning speedily re-routes the particles to the process ▶ Various filter materials can be selected to suit the respective processes Three-component nozzle

▶ Extremely low spraying losses due to the spray nozzle arrangement in the distribution plate ▶ Homogeneous granulates, after-treatment with a sieve mill is no longer necessary ▶ Excellent coating quality and gentle handling of the product during coating ▶ Very short granulation and coating times NexStep ▶ Process development and optimization in the laboratory scale and reliably applied in the production scale via NexStep ▶ Scale-up without intermediate steps

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Drum coater

Dosing

Mixing

Granulation

Fluid bed coating

Drying

Mixing

Compression

Film Coating

Sugar Coating

Fluid bed module

Coater module

Drum coater
Spray gun ▶ Anti-bearding systems with superior spray pattern ▶ Enhanced droplet performance ▶ Tool free, GMP compliant design ▶ Low profile shape with integral connections for reduced airflow turbulence ▶ Retro-fit capability to upgrade existing coating equipment

Interchangeable Drums The Manesty Drum Coater has the ability to change pan sizes/diameters, which makes it ideal for use in the development of products with small production batches and the confidence of scale-up to larger production size coaters. Open Surface The fully perforated side-vented coater drum and cabinet design allows highly effective drying capacity in the process without the need to use high drying temperatures eliminating lower process efficiencies (spray drying) and detrimental thermal stresses on the product.

10 | Laboratory and Pilot Units

Solidlab 1 – Batch sizes ranging from 0.05–1 kg*
Testing feasibility

The advantages of your Solidlab at a glance:
▶ Up to eight functions in one device ▶ Modular layout, compact design ▶ Common control software Provicon ▶ Joint air treatment and sensor technology ▶ Open recipe creation and management ▶ Reproducible and controllable results ▶ High planning flexibility, many available options

The Solidlab 1 laboratory machine processes batch sizes from 0.05 to 1 kilograms and is the equivalent for the highest performance in the smallest space. The plant supports you in developing your products and in examining your recipes. All important parameters and results are recorded by the software, and changes are documented. This makes the Solidlab 1 the ideal solution for your feasibility studies. Fast conversion The fluid bed or the coating module can be easily assembled in the base unit. Both are operated via a joint, integrated air treatment and control system. A conversion to either module is possible in only a few steps.

L

W

Solidlab 1 fluid bed module Solidlab 1 Fluid Bed ● ● ● ● ● ● ● ● Drum Coater Multi Mix insert Drum Coater

H

Mixing Drying Granulating Powder Coating Pellets Coating Tablet Coating
L W

Solidlab 1 drum coater module

Tablet Sugar Coating Blending

H

Exchange of fluid bed and drum coater module in just a few steps

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Solidlab 1 options Working volume max. (litres) Working volume min. (litres) Working Capacity max. (kg) Working Capacity min. (kg) Air flow (m3/h) Max. inlet air temperature °C Dimensions L x W x H (mm) Weight (kg)

Fluid Bed

Fluid Bed optional product container 2 0.4 1* 0.2* 70 80 0.5 0.1 0.25* 0.05* 70 80 1,100 x 730 x 1,010 205

Drum Coater

Drum Coater optional drum 1.5 0.5 0,8 0.25 0.65** 0.2** 70 80 1,100 x 770 x 1,010 240

Drum Coater optional Multi Mix insert 1.5

1.2** 0.4** 70 80 1,100 x 770 x 1,010 240 ** ρ= 0.8 kg/l

– – 1,100 x 770 x 1,010 240

1,100 x 730 x 1,010 205 * ρ= 0.5 kg/l

12 | Laboratory and Pilot Units

Solidlab 2 – Batch sizes ranging from 0.25 –15 kg*
Easy scale-up

The advantages of your Solidlab at a glance:
▶ Up to eight functions in one device ▶ Modular layout, compact design ▶ Common control software Provicon ▶ Joint air treatment and sensor technology ▶ Open recipe creation and management ▶ Reproducible and controllable results ▶ High planning flexibility, many available options

The Solidlab 2 laboratory machine handles batch sizes from 0.25 to 12 kilograms in laboratory scale. The different modules use a common periphery and are constructed like full scale production machines. This enables an easy scale-up of all production parameters. Combi Module The fluid bed and the coater are both operated via a Combi Module with common software. This significantly reduces the need for operative personnel and training. The joint air treatment is located in the technical room, which not only contains the Monobloc but also the switchboard, and enables a space-saving layout.

The control via HMI (Human Machine Interface) eases operation and reduces the training required for personnel.

H

H

H

Solidlab 2 location options Working volume max. (litres) Working volume min. (litres) Working Capacity max. (kg) Working Capacity min. (kg) Air flow (m3/h) Max. inlet air temperature (°C) Dimensions L x W x H (mm) Dimensions (swivelled out) L x W x H (mm) Weight (kg)

Fluid Bed process room 24 2 12* 1* 600 80 860 x 860 x 1,980 1,372 x 860 x 1,980 600 * ρ= 0.5 kg/l

Fluid Bed optional product container 2 0.5 1.0* 0.25* 50 80 860 x 860 x 1,980 1,372 x 860 x 1,980 600

Drum Coater process room

Drum Coater optional drums 16 5 12.8** 4** 600 80 24/8/4/2 7.2/2.4/1.4/0.75 19.2/6.4/3.2/1.6** 5.8/1.9/1.1/0.6** 600 80 1,130 x 1,000 x 1,991 1,862 x 1,913 x 1,991 800

1,130 x 1,000 x 1,991 1,862 x 1,913 x 1,991 800 ** ρ= 0.8 kg/l

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Options ▶ Variable drum inserts ▶ Smaller fluid bed material containers
W W W W

▶ WIP (Wash-in-Place) ▶ Air humidifier and dehumidifier ▶ Active de-dusting unit

L

L

L

Drum Coater optional Multi Mix insert 2–24

Combi Modul process room

Solidlab 2 Mixing Drying Granulating Powder Coating Pellets Coating

Fluid Bed ● ● ● ● ●

Drum Coater

Multi Mix insert Drum Coater

– – 1,130 x 1,000 x 1,991 1,862 x 1,913 x 1,991 800 100 875 x 750 x 1,466

Tablet Coating Tablet Sugar Coating Blending

● ● ●

14 | Laboratory and Pilot Units

Pilotlab – Batch sizes ranging from 4 to 50 kg*
The Pilotlab can be used as a small-size production unit or as an intermediate step from laboratory towards production. The reduction kit assures highest flexibility to the Pilotlab, ranging from 4 to 50 kg. Another ideal feature is the inline solution with the Pilotmix high-shear mixer/granulator.

▶ 10 bar shock-resistant as standard ▶ Process air equipment and circuit cabinet with integrated PLC for separate installation

* at density 0.5 kg/l

From left to right: ▶ Dynamic filter lowered ▶ mobile container ▶ Pneumatic discharging system

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2950

1840

1660

S Pilotlab Container volume (litres) Air flow (m3/h) Differential pressure (Pa) Heating capacity (kW) (Δtmax = 75°C) Steam consumption (kg/h @ 3 bar) Compressed air consumption Number of spray nozzles Electrical connection (kW) Dimensions L x W x H (mm) Weight of Pilotlab (kg) Weight of air handling (kg) Weight of fan (kg) Weight of controller (kg) Technical specifications are subject to change without notice (Nm3/h @ 6 bar) 75 500 16,000 35 59 130 2 30 1,840 x 1,600 x 2,950 1,400 555 500 380

L

100 1,000 16,000 35 59 150 3 30 1,840 x 1,660 x 2,950 1,400 550 500 380

Hüttlin GmbH A Bosch Packaging Technology Company Hohe-Flum-Straße 42 79650 Schopfheim Germany Phone +49 7622 6884-0 Fax +49 7622 6884-111 www.boschpackaging.com info.packaging-scm@bosch.com

Bosch Packaging Technology Ltd. Kitling Road Knowsley Merseyside, L34 9JS Great Britain Phone +44 151 547 8000 Fax +44 151 547 8001 www.boschpackaging.com info.packaging-kny@bosch.com

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