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Toxoplasma IgM Toxoplasma IgG Toxoplasma avidity index Toxoplasma immunoblot
Serum Subject to report!
1. Description: Toxoplasmosis is a world widely spread infectious disease, caused by Toxoplasma gondii, an obligate intracellular protozoan. Toxoplasmosis is known in mammals (especially in felines) and birds and it can be transmitted to humans. This transmission happens most of the time through food of animal origin (often pork meat) that is only partially cooked, or by contact with infected felines or their feces, or finally by an intrauterine route. Postnatally acquired toxoplasmosis This form of toxoplasmosis generally remains asymptomatic, a temporarily swelling of lymph nodes can sometimes be observed as well as an angina or mild cutaneous eruptions. Postnatal acquired toxoplasmosis often becomes latent and can be reactivated in case of an immunodeficiency. Congenital toxoplasmosis With rare exception, congenital toxoplasmosis is due to a primary maternal infection during pregnancy. Infection with T. gondii occurs primarily from ingestion of inadequately cooked meat containing cysts, or ingestion of oocysts derived from cat feces. The severity of the infection depends on the moment of the maternal infection, the virulence and the immune response of the mother. The transmission rate increases with gestational age. An infection during the pregnancy can lead to premature delivery or to stillbirth, less frequently to malformations or severe diseases of the newborn. 2. Clinical relevance: Anti-toxoplasmosis IgM titers significantly increase a few days after infection, reach a peak 2-5 weeks later and finally persists in weak concentrations for 2 years. This titer is not a certain proof of a recent infection. Anti-toxoplasmosis IgG titers can be detected after the second week after infection and persist for life. They are appropriate for evaluation of the immune state of the patient The diagnosis of an acute infection is based on the seroconversion, the presence of antiToxoplasma gondii IgM or the detection of a significant rise of the IgG titer in two consecutive serum samples analysed in parallel. The avidity index of toxoplasmosis is a complementary test after a positive result of antitoxoplasmosis IgG and IgM. It enables recent infections of less than 4 months to be excluded. 3. Indications: Suspicion of toxoplasmosis To evaluate the immune status before and during pregnancy 4. Pre-analytics: 15 -30 C: 2 -8 C : (-10) C: 3 days 14 days 14 days
5. Analytics: Chemiluminescent microparticle immunoassay (CMIA) Enzyme-linked fluorescence assay (ELFA) Western Blot 6. Reference range:
it is recommended to repeat the analysis after two weeks. In presence of anti-toxoplasmosis IgG and IgM. the avidity index helps to reject the hypothesis of a recent toxoplasmosis (less than 4 months).300: Index 0.200 Index< 0.IgM IgG Interpretation negative negative No evidence of infection positive negative Active infection positive positive Recent infection or reactivation negative positive Past infection In case of an equivocal result.300: IgG with weak avidity Intermediate avidity IgG with strong avidity Note: • Before pregnancy: Positive detection of anti-Toxoplasma gondii antibodies: Negative detection of anti-Toxoplasma gondii antibodies: Repeat the test each 8 to 12 weeks until delivery Precaution measures must be taken for pregnant women. • During pregnancy: Positive detection of anti-Toxoplasma gondii antibodies Immune defense. Avidity Index: Index < 0. thus in principle no risk of congenital infection Possible risk of infection Differentiation of the infection stage .200: 0.