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Increased expression of vascular endothelial growth factor in hepatocellular carcinoma after tran...

Acta Radiologica doi: 10.1080/02841850801958890 Acta Radiol June 2008 vol. 49 no. 5 523-529

B. Wang, H. Xu, Z. Q. Gao, H. F. Ning, Y. Q. Sun and G. W. Cao

Author Affiliations

Bin Wang, Department of Radiology, Medical Imaging Center of the Affiliated Hospital, Weifang Medical University, 288 Shenglidong Street, Weifang, 261042, P. R. China (tel. +86 536 8210290, fax. +86 536 2602083, e-mail.

Background: Changes in the biological behavior of residual viable hepatocellular carcinoma (HCC) tissue after transcatheter arterial chemoembolization (TACE) remain unclear. Several studies have reported that TACE inhibits tumor angiogenesis and induces tumor cell apoptosis, while other studies have found that TACE stimulates tumor angiogenesis and thus increases the proliferative activity of the tumor cells to some degree. Purpose: To investigate the intratumoral microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in residual surviving cancerous tissue after TACE in HCC. Material and Methods: Tumor specimens from 63 histopathologically diagnosed patients were studied: 42 comprising the control group (treated by surgery alone) and 21 comprising the TACE group (those treated by TACE 1–2 times prior to surgical resection). The number of VEGF-positive cells, MVD, and microvessel diameter were measured. Results: The MVD was 51.69±18.17 and 58.57±15.75 in the control and TACE groups, respectively. There was no significant difference between the two groups (t=1.48, P>0.05). The microvessel diameter was 17.62±10.54 µm and 15.79±7.65 µm in the control and TACE groups, respectively, indicating no significant difference between the two groups (t=0.71, P>0.05). The number of VEGF-positive cells in the TACE group, i.e., 243.66±88.88, was higher than that in the control group, i.e., 138.26±65.24 (t=5.34, P<0.01). TACE increased VEGF expression in the residual surviving HCC tissues, and there was a positive correlation between VEGF expression and MVD (r=0.4936, t=4.4329, P<0.05) in the HCC tissue. Conclusion: The study indicates that the residual surviving cancerous tissue in HCC after TACE has a rich vascularity. TACE increases VEGF expression in the residual surviving cancerous tissue. Key words
Angiogenesis endothelial growth factors hepatocellular carcinoma

microvessel density

therapeutic chemoembolization

Accepted January 31, 2008. © Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS)

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