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Drug Study

Drug Name Clopidogrel 75mg/tab 1 tab OD Classification: antiplatelet agent

Action Inhibits platelet aggregation by blocking ADP receptors on platelets, preventing clumping of platelets  

Indication Treatment of patients at risk for ischemic events—history of MI, ischemic stroke, peripheral artery disease Treatment of patients with acute coronary syndrome

Contraindication  Contraindicated with allergy to clopidogrel, active pathological bleeding such as peptic ulcer or intracranial hemorrhage, lactation.

Side Effect CNS: Headache, dizziness, weakness, syncope, flushing CV: Hypertension, edema Dermatologic: Rash, pruritus GI: Nausea, GI distress, constipation, diarrhea, GI bleed Other: Increased bleeding risk

Nursing Responsibility Assess for symptoms of stroke, MI during treatment  Monitor liver function studies: AST, ALT, bilirubin, creatinine if patient is on long-term therapy  Monitor blood studies: CBC,Hgb, Hct, protime, cholesterol if the patient is on long-term therapy; thrombocytopeni a and neutropenia may occur. Precautions:  bleeding disorders, recent surgery, hepatic impairment, pregnancy 

Antiinflammatory effects are mediated by a decrease in prostaglandin synthesis.    Precautions:  Do not use in children with chicken pox or flu symptoms Lactation Mild diabetes. leucopenia. anti-inflammatory and analgesic effects.   Indication For pain on integumentary structures. bleeding tendencies. vitamin K deficiency. Other: Thirst. severe anemia. SLE. acute rheumatic fever Contraindication Hypersensitivity to salicylates. Arthritis. The antipyretic effect is due to an action on the hypothalamus. resulting in heat loss by vasodilation of peripheral blood vessels. liver or kidney disease. gout. thrombocytopenia. epigastric discomfort. erosive gastritis. fever. headache. LFTs and CBC Determine history of peptic ulcers or bleeding tendencies.   . skin rashes. location and pattern Note for asthma Monitor renal. urticaria Hematologic: prolongation of bleeding time. dysmenorrhea. heartburn. neuralgia. pregnancy in the last trimester Side Effect GI: dyspepsia.Drug Study Drug Name Aspirin 80mg/tab 1 tab p lunch PO OD Classification: Antipyretic Analgesic (nonopioid) Antiinflammatory Antirheumatic Antiplatelet Salicylate NSAID Action Exhibits antipyretic. anorexia. asthma-like symptoms. 1 week before and after surgery. dimness of vision Nursing Responsibility  Assess for pain: type. potentiation of peptic ulcer Allergic: Bronchospasm. myalgia. history of blood coagulation defects. It also decreases platelet aggregation. anaphylaxis. nausea.

severe renal. activity being performed. character. perspiration. severe anemia. cerebral hemorrhage. apprehension. arthralgia. cutaneous vasodilation with flushing GI: Nausea. retrosternal discomfort. impotence.   Indication Dinitrate: Treatment and prevention of angina pectoris Mononitrate: Prevention of angina pectoris Contraindication Side Effect CNS: Headache. cold sweat.Drug Study Drug Name Isosorbide mononitrate 60mg/tab 1 tab OD at HS PO Action Relaxes vascular smooth muscle with a resultant decrease in venous return and decrease in arterial BP. vomiting. intensity Assess orthostatic hypotension. bronchitis Nursing Responsibility  Assess for pain: duration. atrial fibrillation. postdural hypotension  Classification: Antianginal agent Precautions:  pregnancy. CHF. faintness CV: Tachycardia. blood pressure at baseline and during treatment  Isosorbide dinitrate 5 mg PRN for chest pain Contraindicated with allergy to nitrates. exfoliative dermatitis. lactation. hepatic disease . acute MI. which reduces left ventricular workload and decreases myocardial oxygen consumption. weakness. time started. dizziness. palpitations. incontinence of urine and feces. head trauma. abdominal pain. urinary frequency Other: Muscle twitching. postural hypotension. pallor. orthostatic hypotension. diarrhea GU: Dysuria. postdural hypertension Dermatologic: Rash. restlessness. narrow-angle glaucoma. angina. rebound hypertension. hypertrophic cardiomyopathy. vertigo.

salt/volume depletion. treatment of rheumatoid arthritis. irregular heartbeat. ren al insufficiency. hemolytic anemia. used with diuretics and digitalis  Treatment of diabetic nephropathy  Treatment of left ventricular dysfunction after MI  Unlabeled uses: management of hypertensive crises. anorexia. decreased aldostero ne secretion. chills. swelling of the hands. impaired renal function. sore throat. Do not stop without consulting your health care provider. urinary frequency Hematologic: Neutro penia.  Be careful of drop in blood pressure (occurs most often with diarrhea. and sodium and fluid loss. GI: Gastric irritation. constipation GU: Proteinuria. sweating. angina pectoris. aphthous u lcers. lymphadenopathy Nursing Responsibility  Take drug 1 hr before or 2 hr after meals. Raynaud's syndrome Contraindication  Allergy to captopril.Drug Study Drug Name Captopril Classification: Antihypertensiv e Angiotensinconverting enzyme (ACE) inhibitor Action Blocks ACE from converting angioten sin I to angiotensin II. renal failure. increased prostaglandin synthesis also may be involved in the antihypertensive action. exfoliative dermatitis. malais e. eyes. pruritus. dehydration). hypertension related to scleroderma rena l crisis. chest pains. diagnosis of primary aldosteronis m. tongue.  ·Report mouth sores. . vomiting. Side Effect CV: Tachycardia. h epatocellular injury. leading to decreased blood pressure. pregnancy. scalded mouth sensation. dry mouth. lips. idiopathic edema. lactation. agranulocytosi s. do not take with food. a small increase in serum potassium levels. fever. polyuria. pancytopeni a Other: Cough. feet. MI. a powerful vasoconstrictor. hypotension in salt/volume depleted patients Dermatologic: Rash. peptic ulcers. CHF. thrombocytopenia. CHF. diagnosis of anatomic renal artery stenosis. consult your health care provider. Indication  Treatment of hypertension alone or in combination with thiazide-type diuretics  Treatment of CHF in patients unresponsive to conventional therapy. ch olestatic jaundice. difficulty breathing. olig uria. dysgeusia. Bartter's sy ndrome. if lightheadedness or dizziness occurs. swelling of the face. pemphigoid -like reaction.

sweating. pregnancy. tinnitus. flatulence. slow pulse. anorexia. GU: Impotence. rash. confusion. swelling of extremities. especially diuretics  Treatment of angina pectoris Contraindication  Contraindicated with sinus bradycardia  Use cautiously with diabetes or thyrotoxicosis. nausea. vertigo. CV: CHF.  Swallow the ER tablets whole. vomiting. dry skin EENT: Eye irritation. pruritus. dry eyes. night cough.  Report difficulty breathing. sore throat. asthma or COPD. fever. pulmonary edema.Drug Study Drug Name METOPROLOL Classfication: Antianginals Antihypertensiv es Action Competitively blocks beta-adrenergic receptors in the heart and juxtaglomerular apparatus Indication  Hypertension. depression. alone or with other drugs. · · Side Effect CNS: Dizziness. do not cut. or chew. crush. blurred vision GI: Gastric pain. hypotension Dermatologic: Rash. decreased libido Respiratory: Broncho spasm. · · · · · · . constipation. dyspnea Nursing Responsibility  Do not stop taking this drug unless instructed to do so by a health care provider. cardiac arrhythmias. conjunctivitis. diarrhea.

fever. weakness. swelling.  Report muscle pain.  Institute appropriate dietary changes that need to be made. malaise. changes in color of urine or stool. ast henia GI: Flatulence. may be taken with food. nausea. tenderness. Side Effect CNS: Headache. Lipid-lowering agent secondary prevention of cardiovascular disease in patient with clinically evident CHD . m yalgia Nursing Responsibility  Take this drug once a day. abdominal pain.  Use cautiously with impaired endocrine function. the enzyme that catalyzes the first step in the cholesterol synthesis pathway Indication Contraindication  Contraindicated with allergy to atorvastatin. pharyngitis Other: arthralgia. Do not drink grapefruit juice while on this drug. cramps.Drug Study Drug Name Atorvastatin Classification Action  Inhibits HMG coenzyme A. dyspepsia Respiratory: Sinusitis. constipation. at about the same time each day.

rash. electrolyte depletion. diarrhea. purpura. hepatic coma. Indication  Edema associated with CHF. Side Effect CNS: dizziness. muscle cramps Skin: photosensitivity. orthostatic hypotension EENT: blurred vision GI: nausea. IV)  Acute pulmonary edema (IV)  Hypertension (oral) Contraindication  Contraindicated with allergy to furosemide.  Instruct patient move slowly rising.Drug Study Drug Name Furosemide Classification: Loop Diuretic Inhibits Action the reabsorption of sodium and chloride from the proximal and distal renal tubules and the loop ofHenle. hemolytic anemia Musculoskeletal: muscle pain. headache. PR. thrombocytopenia. leukopenia. anuria. constipation. fluid intake and output and weight.  Watch for signs and symptoms ototoxicity. severe renal failure. allergy to tartrazine (in oral solution). diaphoresis. vertigo. sulfonamides. diabetes mellitus. pregnancy. vomiting. renal disease (oral.  Use cautiously with SLE. CV: hypotension. gout. to dizziness of to when avoid from sudden blood pressure decrease. urticaria. cirrhosis. GU: excessive and frequent urination Hematologic: anemia. pruritis Nursing Responsibility  Monitor BP. leading to a sodiumrich diuresis. lactation. .

back pain. alopecia. dream abnormalities Dermatologic: Rash. urtica ria. asthenia. do not chew. lactation. dry mouth. or crush. apathy. constipati on. epistaxis Other: Cancer in preclinical studies. tongue atrophy Respiratory: URI symptoms.Drug Study Drug Name Omeprazole Classification: Antisecretory Proton pump inhibitor Action Gastric acid-pump inhibitor: suppresses gastric acid secretion Indication  Short-term treatment of active duodenal ulcer  First-line therapy in treatment of heartburn  Treatment of pathologic hyperse cretory conditions Contraindication  Contraindicated with hypersensitivity to omeprazole or its components. insomnia. cough. fever. worsening of symptoms. open.  Use cautiously with pregnancy. inflammation. vertigo. fever . chills. Nursing Responsibility  Take the drug before meals. dry skin GI: Diarrhea. abdominal pain. pruritus. Swallow the capsules whole. dizziness.  Report severe headache. anxiety. paresthesi as. nausea. vomiting. Side Effect CNS: Headache.

Side Effect CNS: seiz ure . insomnia. anenzyme that candestroy penicillins Indication  Appendicitis andperitonitis  Skin and skin structureinfections  Gynecologic infections  Communityacquiredand nosocomialpneumonia caused bypiperacillinresistant.thr ombocytopenia Nursing Responsibility  Assess patient for infection at beginning of and during therapy  Obtain a history before initiating therapy to determine previous us eof and reactions to penicillins or cephalosporins.neutropenia. diarrhea .headache.betalactamase±producing bacteria Contraindication Contraindicated in pregnancy.leuko penia.confusi on. Skin: rashes ( incystic fibrosis patients) . hypersensitivity to piperacillin. druginduced hepatitis.urticaria. dizziness. causing celldeath. GU:interstitial nephritis. .Drug Study Drug Name Piperacillin Sodium Tazobactam Sodium Classification AntibioticExten ded spectrumpenicil lin. GI:Pseudomembrano colitis. Hemat:bleeding. Spectrum isextended compared with other penicillins Tazobactam : Inhibitsbetalactamase.nausea.constipation. vomiting.lethargy. betalactamaseinhi bito Action Piperacillin : Binds tobacterial cell wallmembrane.