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186 [1] 3:30 900 [2] 86:7,8

0 19 [2] 1:7 187:2
4 95 [2] 75:21 136:1
0.2 [1] 286:3 191 [1] 3:31 4 [31] 3:4 20:20 21:8 70:9 72:1 73: 97-99 [1] 175:17
0.4 [1] 286:1 197 [1] 3:32 18 109:9 111:16 114:14 123:7,11 98 [3] 64:15 65:9 121:18
0.9 [1] 33:7 1980 [1] 50:1 156:19 163:17 164:6 167:6,11,12 99 [1] 33:8
0.997 [1] 35:9 1980s [1] 174:7 169:8 202:4,5,8 244:21,21 245:7, 99.9 [2] 31:9 34:1
0.999 [1] 58:15 1985 [1] 191:5 10,14,16,20 246:13 247:5,20 99.99 [1] 34:2
4-12 [1] 118:16
1 1987 [1] 23:15
4-8 [1] 37:18 >
1 [44] 20:18 31:6,18 33:12 38:21 58: 1992 [1] 23:19
1995 [2] 84:14 85:3 4-week [1] 40:5 >90s [1] 174:14
21 66:9 69:4,17 72:2 73:18 109:9 4.1 [1] 22:8
111:16,17 113:10 114:4 143:1
1996 [1] 86:4
4.7 [1] 23:7
]
156:19 174:16 178:6 199:1 202:4
1997 [1] 216:20 ]s [1] 44:21
4:25 [1] 313:1
231:17 240:13 244:20,21,21 245: 2 40 [2] 117:20 164:22 A
7,10 247:4,5,6,12,16 249:5,12 250: 2 [27] 37:1 38:22 46:14 58:20 66:11 40,000 [1] 10:17
14 251:2,13 252:12,17,21 304:4 A-2-ALL [1] 152:8
67:5 69:3 73:18 94:20 109:10 114: 40-50 [2] 113:15 199:6
306:19 a.m [2] 312:4 313:3
21 125:5 143:1 148:19 156:20 400 [3] 34:2,4 301:3 Aadult@ [1] 299:17
1,700 [1] 228:13 157:20 202:11 244:21,21 245:6,7 48 [11] 58:21 72:1 109:9 118:9 143:
1.a [1] 258:6 Aall [1] 296:18
247:6 248:14,19 249:6,10 250:13 2 155:10 156:19 168:17 192:13
1:05 [1] 171:12 AASLD [1] 116:19
20 [7] 84:13 92:18 101:7 104:5 181: 252:12,21 Abbott [2] 6:1 8:19
10 [6] 19:6 101:7 104:5 117:22 217: 22 204:14 313:2 48-week [2] 40:2 162:18
11 228:16 abbreviations [1] 70:18
20-25 [1] 66:10
10,000 [2] 10:21 18:16 20-27 [1] 64:9
5 abide [1] 219:16
10-20 [1] 49:1 5 [1] 17:19 ability [15] 19:9 33:4 52:21 53:3 56:
20-30 [4] 54:3 57:2 74:5 274:17 2 70:21 71:6 75:19 78:22 183:1
10-30 [1] 74:4 200 [4] 11:2 21:7 108:10 201:2 5-10 [1] 136:8
10:35 [1] 106:4 5-7 [2] 74:7 274:18 228:18 277:19,21 286:12 299:3
200-250 [1] 286:7 able [25] 12:3 30:5 40:8,9 105:3,15
100 [14] 30:19 31:20 35:8 43:19 65: 2003 22:6
[1] 5-prime [1] 18:17
10 87:9 120:21 123:10,20 127:2 5.1 [1] 23:8 112:9 149:18 150:22 163:16 167:
2004 [1] 153:20 17,19 168:2 169:17,18 174:13
231:11 247:14 248:22 269:7 2006 [3] 1:7 287:19 313:3 50 [8] 3:19 55:2 72:7 117:10 120:
102 [1] 236:4 21 123:8,11 238:10 176:19 198:5 208:21 245:15 278:
2009 168:11
[1]
15 280:3 302:10 304:2 305:2
1029 [1] 49:5 2010 [1] 49:5 50-60 [1] 174:16
103 [1] 236:4 50-70 [1] 231:18 abnormal [1] 26:16
208,500 [1] 49:1 abnormalities [2] 188:10,11
106 [1] 3:25 20s 204:12
[1] 500-600 [1] 20:22
11 [2] 20:3 49:5 5071 [1] 310:7 abort [1] 274:15
21 [1] 49:6 aboutB-all [1] 110:14
12 [27] 17:17 19:7 40:18 41:5 65:10, 22 [3] 127:21 187:2 262:22 54 [1] 17:18
19 91:19 99:21,22 116:2,7 121:20, 55-year [1] 299:10 above [1] 125:18
23 84:13 306:17
[2]
Aboy [1] 37:7
21 122:2,5 132:21 133:1 163:17 24 [27] 15:6 39:11 58:20 65:10 70: 56 35:1
[1]
164:6 166:22 228:16 263:7 264:6 absence [5] 75:4,10 76:8 78:6 80:
286:2,4 300:14 301:4
11 100:7 109:10 116:3 118:9 119: 6 5
3 120:21 121:4,9,21 122:1 139:15,
12-week [6] 40:16 64:16 92:3 168: 6 [2] 3:6 20:19 absolute [6] 200:4 220:8 230:20
16 143:2 155:11 156:19,21 157:
22 169:9 261:14 60 [1] 31:8 232:2 252:7 281:6
19,22 159:12 162:18 168:17 252:
12-year [1] 298:1 60-plus [1] 286:22 absolutely [9] 50:5 162:20 223:19
13
12:00 [1] 171:11 600 [2] 33:21 255:21 231:6 252:14 254:9 283:20 306:
24-week [4] 63:18 155:11 156:3 600-700-day [1] 162:7 22 307:4
120 [1] 33:9 157:1
12A-30 [1] 8:6 64 [1] 34:22 abuse [1] 189:7
25-plus [1] 87:7 abusers [2] 99:3,4
13 [1] 310:10 25-year [2] 298:2 300:2 7 academic [2] 7:10 309:22
13,500 [1] 217:1 26 [1] 50:1 7,200 [1] 216:20
14 [5] 34:18 36:13 133:13 298:17 academics [1] 191:3
2b [1] 97:6 7-14-day [1] 103:11 accelerate [2] 96:7 217:5
301:4
3 70 [3] 31:8 299:8,10 accelerated [5] 74:2 93:14,19 224:
14-29 [1] 240:13 70-75 [1] 66:8
14-year [3] 299:9,11 300:2 3 [28] 12:20 38:22 58:20 66:12 69:3 72 [4] 32:16 35:18 40:11 155:13 13 274:15
142 [1] 3:26 73:18 101:8 109:10 114:21 143:2 accelerating [2] 96:12 150:15
72-week [1] 156:3 acceleration [1] 224:22
15 [11] 12:16 45:2 107:1,13 109:22 148:20 156:20 157:20 167:5,11
129:10 146:7,8 151:12 204:14 202:11 244:21,22 245:6,7 247:6 8 accept [2] 252:15 265:8
298:17 248:3,3,14,19 249:7,10 250:13 8,000-10,000 [1] 22:14 acceptable [7] 118:13,15 119:11,
15,000 [1] 87:7 3.2 [1] 22:13 13,17,21 138:19
8:00 [3] 1:8 312:4 313:3
15-20 [1] 88:2 3.4 [1] 23:8 80 [8] 71:7,8,9 87:8 116:9 176:1 accepted [1] 251:21
15-minute [1] 257:22 3:00 [1] 237:22 191:21 199:11
access [12] 8:2 85:5,12 90:14 93:
150,000 [1] 86:13 30 [3] 37:19 117:20 199:11 13,19 94:2 96:21 114:21 205:16
80-80-80 [3] 71:13 237:9 254:12
16 [2] 3:13 166:22 30-80 [2] 109:14 199:1 207:4 225:8
800,000 [1] 69:6
17 [1] 46:13 300 [2] 34:4 301:4 800-1000 [1] 301:5 accordingly [1] 30:10
17,000 [2] 79:3 216:22 300-400 [1] 58:16 83 [1] 3:22 account [4] 43:7 247:19 249:16
170 [1] 108:10 33 [1] 310:9 306:12
85 [4] 53:15 247:11,14 248:21
174 [1] 3:28 35 [1] 17:18 accounting [1] 75:21
18 [2] 148:14,15 35-40 [1] 204:11
9 accrual [1] 308:21
18-gauge [1] 67:17 36 [1] 128:5 9 [1] 3:10 accrued [1] 206:10
180 [1] 3:29 3A4 [2] 227:15 230:5 90 [5] 31:9 33:7,20,20 311:11 accumulation [1] 81:7

Sheet 1 0.2 - accumulation
accuracy [1] 67:13 233:3 246:2 252:22 275:11,17 3 46:17 143:5 180:2 191:15 220:7 236:10
accurate [2] 23:5 124:14 additional [10] 16:5 48:4 146:4 affected [4] 88:8 91:5 98:21 188:3 Albrecht=s [1] 197:17
achieve [25] 39:13 40:17 41:4 48: 168:4,5,11 232:9 273:12 274:5 affects [5] 43:2 60:5,6 267:7 286:1 albumins [1] 110:22
6 62:5 65:7,21 67:5 71:7,12 77:22 312:5 affiliated [2] 186:13,17 alcohol [4] 18:1 46:3 99:3 189:7
80:5 116:1 118:1 128:1 137:2 141: Additionally [1] 187:20 affiliations [1] 173:20 algorithm [2] 20:4 166:21
17 154:5 174:21 184:4 274:6,12 additive [1] 132:19 afford [1] 78:21 algorithms [1] 19:21
279:7 302:10,17 address [19] 9:4 70:3,4 95:19 142: African [20] 71:20 75:18 98:10,15 allograft [1] 274:8
achieved [8] 56:18 80:3 83:10 7,20 143:18 173:9 184:13 185:22 112:21 114:6 188:22 199:5,8 200: allow [10] 60:12 80:15 82:3 162:10
120:10 127:21 128:5,12 163:9 193:22 196:4 197:14 208:9 258:2 16,22 201:8 302:20 304:8 306:10, 163:19 164:4,10 262:7 264:8 267:
achievement [1] 128:7 271:19 273:21 290:10 303:22 16 307:19 309:4 310:9,17 21
achieving [2] 69:2 75:8 addressed [7] 88:20 185:6 190:10 afternoon [2] 180:5 233:21 allowing [1] 51:2
acid [1] 277:20 193:18 195:15 209:21 304:19 age [16] 17:18 21:17 286:2,4 287: allows [4] 56:9 81:6 164:8 182:16
acknowledge [3] 9:17 108:11 addresses [2] 6:15 70:8 19 289:17 291:7 292:5,8,10,11 almost [10] 11:2 35:9 74:7 199:3
154:22 addressing [4] 17:13 90:1 181:12 293:19 298:19 300:13,17 301:11 275:15 276:6 277:3,11,18 279:1
acknowledges [1] 8:8 224:2 aged [2] 108:21 301:4 alone [11] 11:10 100:13 101:3,6
acquainted [1] 87:12 adds [3] 28:5 59:21 256:16 agencies [1] 88:17 153:7 233:13,14 286:7 289:6 292:
acquired [2] 287:1 290:6 Adefovir [1] 272:19 agency [17] 16:19 107:14 121:10 18 304:4
acquiring [1] 279:9 adequacy [1] 170:22 139:17 142:8 155:7 156:20 157:1, alpha [2] 11:9 72:15
across [7] 19:15 36:4 37:10 122:5 adequate [16] 67:9,12 70:21 91:7 3,8 170:3 171:3,9 210:14 243:15 alpha-2a [1] 42:1
188:17 257:14 275:4 92:9,22 93:6 104:2 164:6 191:21 255:21 311:15 alpha-2b [4] 41:3 42:2,5 71:2
Act [5] 88:16 89:3,3 185:1 222:7 245:19 246:12 260:6,7 263:13,18 agency=s [2] 8:6 185:17 alpha/beta [1] 59:11
ACTG [3] 84:15 105:13 310:7 adequately [3] 98:16 195:12 305: agenda [2] 8:22 15:11 already [23] 8:21 90:20 98:18,18
Acting [3] 2:2 3:4 8:15 21 agent [39] 14:11,19 30:5 31:10 36: 100:6 109:3,5 111:8 113:2 115:2
Action [9] 5:4 32:13 51:11 59:3 62: adherence [2] 71:4 266:21 14 100:15 124:12 129:21 130:2, 119:8 128:15 132:11 140:19 170:
3 133:10 181:11 183:13 185:9 adjourn [2] 171:10 312:3 16,19,22 131:3,15,22 132:2,11,11, 19 190:9 237:18 258:8,11 262:19
activation [1] 53:2 adjourned [1] 313:2 13,20 133:2,12 140:14,19 158:22 280:18 287:6,7
active [10] 23:8 73:3 75:4 77:8 78: adjunct [1] 277:21 169:9,21 179:9 197:12 235:4 242: ALT [4] 53:16,21 75:1,19
7 118:14 144:5 180:11 260:1 312: ADMINISTRATION [6] 1:2 7:16 14,16 248:2,6 252:12 253:9 256: Alter [41] 2:14 16:13,13 21:15 49:
16 61:20 118:13 132:20 172:11 12,16 277:21 21 142:18,19 146:15 150:9 151:
actively [2] 215:2 217:1 adolescent [1] 301:4 agent-to-agent [1] 36:10 14 166:21 205:5,6 206:17,18 213:
activity [7] 68:14 132:14 133:13 adolescents [2] 299:15 301:8 agents [60] 14:22 19:22 29:22 38: 11,12 215:3,10,12 216:19 245:12,
140:20 161:15 245:6 298:7 adopt [1] 125:10 8 42:1 51:14,18,20 64:22 75:8 81: 13 246:8 249:12,13 251:7 253:12,
actual [6] 34:9,20 35:12,18 39:19 Adrian [1] 44:20 13,13 94:17,20 97:7 100:13 101:3, 13 254:2,12,18 303:16,17 304:7,
277:4 adult [11] 5:11,14 53:15 186:13,17 6 104:4 114:21 117:7 119:16 124: 10 305:6,10 307:5 309:12,13
actually [60] 20:1 29:6 34:17 35:4, 298:18 299:11 300:3,4,5 301:2 8 125:8 131:6 133:7,21,22 140:2, altered [3] 47:18,19 145:2
9,13,17,21 37:1 41:17 55:16 61: adults [11] 114:3 137:16 285:22 20,22 141:13 145:14 154:5 158: alternatives [1] 194:5
16 65:19 67:20 68:18 84:17 85:2, 286:9,14 287:3,9,13 288:6 290:16, 12 159:19 160:13 161:12,19 179: although [12] 47:9 71:1 72:3 84:8
5 90:5 106:15 120:19 134:14 146: 22 16 184:17 185:11 191:14 195:20 135:18 167:16 218:9 239:22 266:
15,19 147:10 150:13 152:14 153: advance [3] 76:2 282:5 298:13 218:19 236:2 239:6 247:3 251:2 12 289:15 292:11 306:21
15 154:14 155:5 156:6 158:2,6 advanced [16] 53:4 69:11 76:21 253:1 260:22 275:5,17,17 276:14, ALTs [1] 136:12
160:14 172:9 175:19 182:1,6,11 113:19 143:11 153:12 167:5 187: 15 277:3 278:17 282:7,7 Amany [1] 83:8
194:8 205:6 206:7 213:21 214:5 12 194:21 195:10 211:6 222:4 ages [1] 286:20 amazing [1] 50:2
215:1,5,6 220:6,18 238:7,14 241: 266:9,9 293:5 298:20 aging [3] 108:14 199:14 217:4 amazingly [1] 280:6
15 247:3 248:13 250:4 281:10 advances [2] 50:3 112:15 ago [9] 20:22 25:17 26:20 85:18 American [5] 66:14 188:22 306:16
286:5 292:19 299:18,22 advancing [3] 60:1 66:19 205:3 89:1 92:14 105:8 112:8 148:4 309:4 310:9
Acure@B-for [1] 84:22 advantage [2] 254:11 255:4 agonists [1] 12:10 Americans [20] 66:10 71:20 75:18
acute [6] 22:6 26:4 45:4 50:22 181: adverse [7] 76:19,20 82:1 151:18 agree [26] 113:21 194:2 203:15 98:10,15 112:21 114:7 199:5,8
21 183:3 210:17 211:1 279:19 205:14 216:9 220:11 223:18 237: 200:16 201:1,9 216:21 302:20
acutely [2] 182:1,16 adversely [1] 224:20 3,6,14,15,18 238:4 240:5 243:14 304:8,11,19 306:10 307:19 310:
adapt [1] 277:11 advice [3] 12:3,4 250:12 255:2 256:2 257:5 277:5 281:6,21 17
adaptable [1] 280:21 advise [2] 172:20 173:7 283:20 296:6 297:7 305:10 307: Amiles [1] 49:21
adapted [1] 278:2 ADVISORY [10] 1:4 3:4 4:4 6:20 9: 15 Among [16] 17:18 21:20 28:3 62:2
adaptive [1] 60:8 18,20 52:4 106:11 172:15 186:18 agreed [3] 85:11 214:20 270:9 107:4 117:16 123:10 132:5 140:
adapts [1] 19:14 Advocacy [2] 3:22 83:18 agreement [9] 115:17 116:12 122: 13 166:14 199:1 210:1 235:15
adazanovir [1] 301:3 advocate [13] 77:19 78:3 187:17, 10 130:2 140:13 211:4 225:16 276:15 310:17,18
add [14] 14:13 130:21 152:1 158:4 20 188:12 189:21 217:20 234:10 244:2 311:16 amongst [2] 98:4 99:5
176:9 224:21 225:4 228:1 235:4 236:19 248:1 276:20 280:13 281: ahead [11] 90:1,7 91:1 96:2,3,11 amount [7] 31:7 91:7,12 92:22 93:
240:20 281:16 282:2 301:10 307: 1 99:7 209:4 231:2 254:7 301:12 7 166:14 261:13
17 advocateB-we [1] 207:2 Ahold [1] 224:5 amounts [4] 33:5 67:19 69:5 70:
add-on [2] 159:14 262:6 advocated [1] 216:18 AIDS [7] 3:22 83:18 87:5 97:19 98: 22
added [4] 31:6 169:9 264:17 269:7 advocates [1] 138:1 4 186:13,17 ample [1] 15:20
adding [12] 14:10 129:21 130:2 advocating [4] 228:7 278:5 279:5 aim [1] 200:21 amplification [2] 25:11,12
131:15 132:1 140:14 159:13 171: 305:2 akin [1] 235:6 amplify [1] 261:18
2 179:8 193:11 252:12 255:14 AE [2] 252:4,8 Alan [1] 42:6 amplitude [1] 182:11
addition [14] 4:14 8:4 130:20 160: AEs [5] 83:1 252:1 255:6,8 256:3 Albany [3] 5:15,16 10:2 analogous [3] 131:5 242:11 282:4
21 179:5 195:20 215:22 221:2,5 affect [7] 32:11 34:6 39:4 42:3 43: Albrecht [8] 3:28 173:19,22 174:1 analogs [3] 12:9 151:16 153:11

Sheet 2 accuracy - analogs
analogy [4] 22:10 125:9 163:2 239: apparent [2] 117:15 269:20 Aprior [1] 270:15 attendant [2] 11:19 109:12
1 apparently [1] 170:3 arbitrarily [2] 67:3 69:5 attendees [1] 87:7
analyses [2] 153:4 213:9 appear [5] 109:19 112:22 227:15 arbitrary [2] 41:11 166:8 attention [9] 26:2 58:14 85:9 108:
analysis [19] 22:20,21 42:15 58:2 236:1 309:8 area [18] 16:21 98:11 111:9,10 177: 3 142:4 152:15 186:9 202:4 217:
61:12 64:16 76:19 77:17 145:19 appearance [1] 6:17 1 187:6 192:12 196:13 250:11 15
146:2 161:17 163:19 167:7 170: appears [7] 19:4 24:12 35:22 46:5 252:5,8 271:18 274:9 280:17,22 attract [1] 204:9
11,11 268:11 275:7 277:22 289:8 103:13 132:7,13 282:3 285:11 301:20 attributable [3] 22:14 210:11,12
analyzed [2] 71:18 195:9 applaud [1] 180:17 areas [11] 18:22 44:14 47:16 68:1 AUC [1] 164:3
analyzing [2] 67:11 180:21 applicability [3] 7:8 66:13 100:20 97:21 107:5 108:2 130:5 135:20 augment [3] 56:11 62:20,22
ancestor [1] 20:8 applicable [2] 124:2 165:2 204:12 279:1 augmentation [1] 62:4
ancillary [2] 152:12 168:8 applicably [1] 145:21 aren=t [6] 135:21,22 195:12 207: augmenting [1] 58:22
and/or [4] 13:10 81:15 131:11 170: application [7] 13:8,9 215:18,19, 13 226:9 307:8 author [1] 40:15
13 20,22 248:15 arena [4] 187:6 224:7,8 280:21 authors [1] 128:8
Andersen [32] 2:5 5:19,19 7:19 applications [1] 13:14 argue [3] 76:11 262:12 267:9 availabilities [1] 78:5
158:4 169:5,6 212:15,16 229:8,9 applied [1] 125:11 argued [1] 89:21 availability [1] 280:8
239:9,10 246:14,15 248:16,17 applies [1] 311:1 arguing [3] 296:21,22 297:1 available [23] 7:22 8:2 27:2 41:1
251:9,10 265:2,3,13 266:1 272:6, apply [7] 7:12,15 124:1 205:11 argument [8] 78:16 89:19 90:4 53:17 54:8 69:19 148:6 165:16
7,19 303:2,3 305:1,7 308:5,6 208:5 210:10 229:5 227:3 235:19 261:9 291:2 298:13 179:2 205:22 212:18 214:17,19
Andy [1] 42:5 applying [1] 230:6 arise [2] 210:12,17 218:21 232:16 244:22 260:12 262:
anemias [1] 81:1 appreciate [3] 93:21 190:15 196: arising [1] 19:12 21 264:10,19 289:5 294:11
Angeles [1] 86:7 11 arm [5] 86:10 117:18 143:6,6 278: average [4] 88:3 113:19 114:20
animal [3] 96:7,9,17 appreciated [2] 156:16 185:19 21 194:13
Annals [1] 98:1 approach [12] 88:7 95:3 134:6 armamentarium [1] 184:14 aviremic [4] 274:6 279:7 282:15,
announcement [1] 6:14 154:18 162:22 170:2 177:20 209: arms [7] 7:3 59:6 131:22 155:10, 16
Another [23] 33:16 103:9 115:12 3 221:20 248:20 256:6 294:12 21 266:4 278:21 avoid [5] 103:20 120:5 190:7 212:
122:9 128:4 131:2 152:6,7 162:21 approachable [1] 209:14 around [11] 33:17 41:21 42:17 86: 18 274:8
168:12 169:10 176:14 179:9 227: approaches [3] 185:18 216:22 6 87:8 133:3 144:15 187:6 211:14 avoidance [1] 126:17
2 235:4 237:20 255:14 282:18 264:15 273:3 277:22 Award [1] 9:20
283:1 284:4 289:12 303:14 310: approaching [1] 64:8 arrive [2] 244:15 246:5 aware [8] 83:3 117:9 168:21 169:
21 appropriate [20] 7:3 14:10 26:3 arsenicals [2] 82:22 83:1 14 182:20 190:10,14 291:15
answer [28] 101:9 123:14 137:21 118:8 121:16 125:19 156:22 203: article [2] 98:1 151:5 away [5] 122:12 133:1 163:21 189:
145:5,9 146:14,16 149:10,17 156: 13 207:5 209:17 213:17 239:15 articles [1] 135:17 16 255:21
9 157:11 159:5 167:16,19 171:3 245:7 248:20 265:15 276:17 278: articulated [3] 119:4 132:10 135:7 Awell [1] 249:21
198:5 200:7 208:1 218:11 220:6 2 281:3 283:14 311:20 articulation [1] 219:15 Awouldn=t [1] 125:14
225:14 244:10,15 248:7,10 264: appropriately [1] 194:3 ascertain [1] 278:10 axis [1] 71:22
13 285:7 296:5 appropriations [1] 167:18 ascites [2] 45:13 110:20 Ayou=re [1] 136:6
answers [5] 44:16 94:22 96:22 99: approvable [3] 132:16 248:4 257: Asia [1] 20:18
7 198:21 17 Asians [1] 304:21
B
antagonize [2] 57:15 60:22 approval [94] 13:6 93:14,19 95:22 aside [1] 297:8 B-we [1] 270:7
Anthony [4] 3:30 186:12,15,16 137:15 138:7 162:22 177:7,11,19, aspect [1] 32:21 B/hepatitis [1] 112:14
anti-HCV [1] 132:14 22 197:1,12,18,18 205:19 206:13, aspects [2] 69:1 154:20 back [20] 4:15 28:5 38:16 41:17
antibody [1] 26:5 16 208:9,10 209:22 211:19 212:8 aspiration [1] 67:18 106:9 132:1 157:17 165:19 166:
anticipate [3] 154:4 183:5 278:15 215:21 216:4,12 217:21 218:21 assay [2] 34:22 41:18 10,22 169:6 173:14,16 176:3 207:
anticipation [1] 307:18 224:14 225:15,19 226:6,11,11,13 assays [5] 25:8 26:8 27:2 97:8 19 208:18 226:19 241:4 254:19
antigen [1] 56:5 227:17,21 228:9,12 230:15 233:9, 193:1 267:14
antigen-specific [1] 184:9 13 234:8 235:11 241:22 243:9 assembly [1] 108:10 backbone [6] 159:9 175:6 176:8
antihepatic [1] 282:8 244:3,20 245:1,14 246:6 247:22 assess [3] 67:2 161:11 233:5 179:17 209:11 290:15
antimicrobials [1] 277:12 249:6,7 250:13 251:16 253:11,21 assessed [1] 166:1 background [2] 17:1 84:11
antiretorviral [1] 260:2 257:10,13,13 258:19 260:10,13 assessing [1] 19:21 bad [6] 47:4 104:19 108:13 258:7
antiretroviral [6] 73:3 259:15 260: 263:16 264:9,11,21 268:8 269:2 assist [1] 107:21 272:3 279:19
21 261:3 263:1 267:21 270:21 271:1 281:4 282:1 284:13, associated [8] 18:3 21:9 25:21 30: balance [5] 55:20 56:18 213:7 280:
antiretrovirals [2] 260:16 264:2 16,17 285:19 288:9,18,22 294:2,6, 15 47:19 49:17 51:4 151:7 7 299:3
antisense [1] 12:10 14 295:18 296:14,20 297:2,3,5 assume [3] 43:7 161:4 300:1 bar [2] 242:6 289:2
ANTIVIRAL [28] 1:4 3:4,10,25 4:3 301:17 305:13,14 311:7 assumes [4] 43:9,13,16,19 Baraclude [1] 180:15
6:6,10,19 29:22 51:14 59:3,19 89: approvals [2] 207:16 311:5 assuming [7] 146:22 191:12 206: barest [1] 261:12
21 133:13 159:14 160:5 161:1 approve [2] 250:7 283:17 19 228:9 252:21 297:20 298:2 barrage [1] 57:17
163:4 169:21 181:8 183:7 184:17 approved [23] 11:10 13:16 86:5 assumption [4] 207:1 224:1,2 barriers [3] 200:19 309:2,8
185:10 186:3,5 282:4,5,22 91:11 138:17 205:16,20,22 230: 242:13 base [1] 40:2
antiviral-based [2] 89:18 159:17 10 235:10 239:3 262:22 269:10 assured [1] 118:14 based [34] 19:20 22:18 23:11,12,
Antivirals [4] 6:8 159:21 183:14 287:15 288:1,5 289:3,17,21 290:2 asterisk [1] 120:8 21 25:14 26:6 39:13 41:9,11 48:
251:8 295:8 296:2 299:16 at-risk [1] 167:5 13 49:11 66:7 69:3,8 75:1,2 81:21
anybody [1] 158:11 approving [1] 285:8 attack [1] 56:12 109:15 122:11,17 123:21 151:8
Anyway [5] 148:10 166:11 213:19 Approximately [11] 10:17,19,21 attempt [1] 57:19 159:19 165:8 166:12 168:13 169:
267:1 278:4 18:16 48:3 79:3 201:2 286:1,3,6 attempted [1] 127:16 1 180:8 187:5 233:13 236:15 250:
Apelian [4] 3:29 180:3,4,7 308:13 attempts [2] 127:21 275:1 18 292:17
apoptotic [1] 57:7 approximation [1] 164:16 attendance [1] 173:5 baseline [3] 40:18 113:10 269:13
bases [1] 72:14
Sheet 3 analogy - bases
basic [3] 29:12 225:21 263:14 big [7] 17:12 38:20 42:11 191:16 box [1] 265:4 capacities [1] 277:8
basically [15] 40:16 106:20 113:6 269:5 296:18 309:3 Boy [1] 251:17 capacity [13] 28:1 56:12 57:14 60:
116:13 125:14 128:18 134:15 137: bigger [1] 297:2 Branch [2] 16:15 20:6 18 61:9,17 62:4,9,12,21 63:6 145:
3 138:7 139:2 154:15 187:6 189: bilirubins [1] 110:22 branches [2] 20:10,12 2 170:12
13 212:16 272:20 Bill [3] 6:5 13:1 15:17 brave [2] 119:19 197:16 carcinoma [16] 21:10 45:16 48:6,
basis [15] 12:15 66:19 71:18 75:20 billion [3] 49:5,6 88:16 breadth [1] 137:20 12 54:16 80:5 82:11 108:16 124:
136:18 141:22 150:19 156:5 180: biochemical [5] 15:5 99:18 125:6, break [7] 83:16 89:9 106:4 142:6, 21 154:2 166:19 167:13 168:7,10,
20 201:19 246:11 277:13 279:1 18 140:2 15 257:22 258:6 21 217:6
308:15 311:22 biochemistry [1] 54:7 breaks [1] 4:13 cardiovascular [1] 188:10
bat [1] 212:7 biologic [1] 308:2 breakthrough [1] 65:14 care [80] 11:12,14,17 13:21 14:11
bathroom [1] 42:22 biologically [3] 144:9 297:18 298: Brian [2] 22:16 307:6 49:6 51:13 59:6 70:5 73:14 75:9
Baylor [1] 6:2 18 bridges [1] 47:15 76:3 77:8 82:5 85:19 86:2 88:15,
bearing [1] 117:3 biology [5] 265:22 297:21 298:3 brief [4] 16:21 106:5 258:4 285:13 19 89:3,3 94:13 103:3,8 109:7
became [1] 92:14 299:8 300:21 briefly [7] 15:10 18:7 29:12 51:8 111:17 113:3 118:11 129:22 130:
become [11] 27:20 40:2 56:3,6 87: biomarkers [1] 168:8 74:18 312:6,7 20 131:4,11,21 132:2,16 134:7,8,
11 120:9 170:14 176:3 181:17 biopsies [6] 46:22 61:11 67:15 68: bring [12] 30:5 123:2 138:20 166: 18 139:4 140:15,21 143:3,7,10,15
187:10,12 9,16 281:10 10 213:1 222:7 229:12 247:14 147:7 148:22 149:3,21 156:18
becomes [5] 26:8 121:4 129:3 biopsy [14] 47:1,1 54:5,8 66:17 67: 248:17 260:20 261:10 310:22 157:2 158:11 166:16 169:10 189:
187:12 303:5 8,18,21 68:3 75:2,3 101:13,21 bringing [1] 266:2 15 207:22 209:11,13 217:17 240:
becoming [1] 167:11 293:1 brings [1] 81:3 19 242:2 252:11,20 253:5 262:7
began [3] 23:16 49:22 148:4 biphasic [2] 58:1 183:10 broad [3] 177:4 182:5 207:16 264:17 269:7 272:21 275:9,12,13,
begin [13] 9:9,16 29:9 30:22 33:3 Birnkrant [28] 2:22 3:9 6:9,9 9:10, broaden [1] 225:3 16 276:19 278:3 287:8,12,12,13
51:8 142:7 164:16 197:14 232:22 15 10:6 16:18 21:11 22:4 108:13 broader [2] 7:8 259:19 289:5 290:4 292:22
233:5 292:6 309:14 157:14 211:3,4 214:16 215:16 broadly [1] 234:16 careful [8] 124:1 153:4 170:11 210:
beginning [4] 163:12 172:19 173: 216:11 248:12 250:9,11 271:4,5 brought [7] 108:3 118:19 125:9 22 242:4 259:7 295:15 296:19
6,10 288:12,13 292:4,5 300:11,12 142:8 148:3 282:5 303:3 carefully [5] 189:21 238:14 267:13
beginnings [1] 47:15 bit [23] 22:17 28:12 47:2 66:5 68: bugaboo [1] 248:18 278:14 307:22
begs [1] 266:19 21 84:11 85:18 98:9 100:4 112:11 Building [1] 8:7 carinomas [1] 136:4
behalf [2] 8:15 198:16 132:8 158:18 163:11 207:20 208: bulk [2] 107:2,12 carry [2] 128:4 188:2
behave [4] 42:2 117:4,8 298:18 2 210:15,22 216:5 242:12 262:18 bump [3] 25:20 26:12 169:11 cartoon [1] 28:8
behind [1] 4:16 294:7,8 300:18 burden [4] 10:15 24:13 217:6 230: case [13] 24:13 34:18 91:6 92:7 97:
believe [30] 87:15 108:6 121:7 126: bits [1] 135:19 1 21 98:2,5 181:12,18 198:11 208:1
5 129:3 130:10 145:12,13 150:14 black [3] 188:22 307:13 311:9 burst [1] 43:12 215:5 297:9
151:19 170:10 172:12 175:9 176: blacks [4] 21:21 304:7,14 307:4 bursts [1] 57:13 cases [7] 31:21 49:15 123:1 125:3
7 177:6 184:2,11,19 200:16 224: blamed [1] 94:21 button [1] 4:7 154:16 163:4 272:1
16 229:1 234:6 255:15 264:16 Blatt [1] 66:7 catch [1] 126:7
280:17 285:6 304:17 307:1,1,3 bleeding [3] 45:14 110:20 167:9
C categorically [2] 283:13,17
believes [1] 172:16 blip [2] 35:18,22 C-specific [1] 282:7 categories [13] 25:1 66:3 69:16
Bellevue [1] 84:17 blocked [1] 43:1 calcineurin [1] 277:9 206:5 215:17 218:9 219:14 227:1
below [2] 34:21 165:10 blocking [2] 30:20 31:4 calculates [1] 29:17 235:16 283:18 294:1 295:19 296:
benefactors [1] 109:21 blocks [1] 30:21 calculations [1] 238:11 16
beneficial [2] 159:1 169:11 blood [11] 23:18 47:18,19 53:17 California [3] 5:12 190:18 191:3 category [7] 134:17 154:21 181:8
benefit [19] 124:19 128:4 134:5 57:1 160:21 183:16,20 195:14 Call [12] 3:2 4:2 19:12,17 37:15 47: 206:7 218:19 273:7 296:10
142:2 146:5,6 153:21 166:17 168: 260:6,7 6,20 58:14 173:17 179:11 197:15 Caucasian [1] 72:6
21 169:4 185:3 192:3,21 204:19 bloodstream [1] 27:16 237:22 Caucasians [2] 71:20 304:6
205:4 250:2 269:20 284:9,11 blue [3] 47:4 52:19 69:3 called [6] 4:4 31:18 32:8,19 116:5 cause [9] 27:19 52:21 59:7 97:18,
benefits [1] 184:5 blunted [1] 55:1 152:7 22 98:3 99:2 187:10 230:8
best [6] 81:4 119:7 123:16 178:20 board [3] 100:18 106:22 186:19 came [7] 23:4 102:16 142:15 143: caused [1] 261:5
242:1 286:11 Bob [1] 16:11 16 148:6,10 190:19 causes [3] 17:15 57:7 132:22
bestow [1] 9:19 body [2] 24:19 302:22 camera [1] 295:7 causing [3] 44:3 73:4 127:14
bet [1] 299:6 bolus [2] 21:17 48:14 camp [2] 113:7,16 cautious [1] 141:12
bets [1] 121:22 bone [1] 127:13 camps [1] 113:7 caveat [2] 205:21 287:10
better [22] 42:6,12 74:14 95:10 boosting [1] 266:17 can=t [23] 42:20 43:22 94:10 100: caveats [1] 67:7
112:17 148:21 151:11 164:8 175: born [1] 24:2 10 101:8 124:18 128:12 143:14 CD4 [5] 55:11,20 56:1,21 60:8
4 179:5 181:1 190:1 217:9 219:14 Boston [2] 5:21 16:10 149:16 189:19 217:13 240:17 241: CD8 [1] 55:12
222:16 237:11 241:20 250:5 261: both [45] 13:8 15:21 17:8 18:12 21: 12,18 244:15 246:3,3 260:19 261: CDC [5] 21:14 22:7 23:6,11 24:4
6 290:17,22 298:21 9 32:5 36:22 41:20 48:12 50:22 1 288:20 289:4,4 309:18 cell [10] 43:16 56:2,4,5,13,18 57:8
between [25] 17:18 34:3 37:21 38: 55:10 57:8 71:9 72:5 87:17 111: cancel [1] 27:4 59:8,20 82:5
7 47:16 49:5 52:8 68:16 101:21 22 119:12 122:21 123:1,13 125: cancer [4] 149:16 180:10 195:6 cells [21] 30:9,11 32:1 52:10 53:2
117:5 141:11 184:21 199:11 204: 16 155:13 156:3 172:12 177:8 222:22 56:7,15 57:3,18 58:9,17 60:10,11,
14 207:12 211:15 213:2 237:7 188:13 191:6 208:14 233:14,21 candidacy [1] 74:18 14 68:8,8 82:4 135:20 162:16 184:
245:20 250:19 251:22 266:3 280: 234:7,10,19 237:4 238:4 243:20 candidate [1] 59:1 7 246:20
8 294:6 312:14 244:12 261:18,22 262:13 266:8 candidates [5] 75:7 137:15 138:7 cellular [6] 181:20 182:4,10,15,22
beyond [3] 95:4 116:3 165:12 267:19 268:21 281:18 302:17 151:12 266:16 185:2
bias [1] 205:18 bottom [1] 75:9 cannot [3] 94:11 154:14 307:1 CENTER [8] 1:3 3:19 5:8 6:18 10:
Biceglie [1] 44:20 Boulder [1] 180:9 capabilities [1] 38:10 2 21:22 210:6 281:16
capable [3] 81:5 82:4 167:15
Sheet 4 basic - CENTER
centers [8] 32:18 129:1 185:17 4,6 134:2 152:11 174:6,10 180:11, cleared [8] 27:17 30:12 35:1,9 44: collaboration [1] 105:9
225:6 267:18 272:22 274:4 281: 12,15 183:3 186:8 306:16,18 2 162:16 242:19 293:13 collagen [2] 53:3 61:19
21 chronically [3] 11:2 181:17 182:9 clearing [2] 165:17 184:7 collagenase [2] 61:17 68:14
certain [28] 11:18 13:17 62:14 87: chronicity [2] 45:5,6 Clearly [33] 14:3 37:20 42:14 46: colleagues [4] 67:16 70:7 186:21
20 88:9 90:16,16 91:9,12,12 92:2 Chung [42] 2:16 7:18 16:8,8 89:19 16 73:22 74:20 80:6 95:16,22 109: 312:12
93:1,2 97:20,21 120:9 125:12 141: 151:4 158:1,2 159:7 163:2 209:18, 15 111:3 117:18 144:7 160:16 collect [3] 34:15,16 215:2
2 165:10 181:2 204:8 210:20 225: 19 220:18 233:19,20 235:12,13 163:5 169:16 181:3,13,16 199:13 collected [1] 212:9
6 226:22 238:21 239:2 245:8 302: 236:19 242:8,9 243:19 247:1,2,21 201:18 204:13 212:20 214:19 232: collecting [1] 97:11
11 248:6 249:4 250:15,16 251:17 6 239:5 253:5 258:12 259:1 263:2 College [3] 5:2,15 6:3
certainly [36] 43:15 52:1 81:13 83: 252:18 253:4,22 254:9 257:4,5 265:18 274:20 277:17 color [1] 306:4
13 99:4,16 117:8 121:14 135:8 261:17,18 272:15 281:5,6 307:14, clinic [2] 182:19 212:12 Colorado [1] 180:9
140:8 145:8 147:9 151:20 152:19 15 Clinical [55] 3:14 5:22 6:20 11:14 combination [11] 11:11,12,15 133:
155:19 175:9 179:17,21 193:20 Chung=s [1] 211:5 12:17,21 13:1 21:1 37:4 39:17 41: 11 162:19 185:11 240:3,3 244:22
196:14 198:14 201:14 203:11 207: chute [1] 102:17 8,14 47:7 50:8,12 51:17,19,20 52: 249:15 252:22
13 209:19 210:19 216:17 277:3 Cicely [4] 2:3 3:6 5:9 6:11 3 55:5 60:2 65:16 75:16 80:15 81: combinations [4] 11:16 160:13
280:13 285:15 291:10 292:10 293: Cincinnati [1] 3:19 12 96:11 100:8,9 106:18 130:3 185:16 254:21
1 295:3 311:5,7 circles [1] 47:3 135:3 137:4 139:1 157:16 166:9 combine [2] 94:19 213:4
Chair [2] 2:2 3:4 circumstance [3] 162:8,14 275: 174:2 176:11 179:15 186:14,17 combined [6] 153:7 161:4 179:20
Chairman [1] 173:22 19 190:21 191:4 192:12 194:12 242: 246:22 256:22 264:1
challenge [6] 95:9,18 138:15 224: circumstances [1] 52:14 4 245:11 250:4 253:19 266:10 combines [1] 17:22
19 236:9,14 cirrhosis [65] 21:10 38:22 39:2 45: 278:3 281:20 282:19 300:13 309: combining [2] 94:16 97:7
challenges [1] 94:18 6,11 46:14,18 47:6,6,8,10,12,17 2 311:3 come [24] 9:22 16:5 17:1 26:2 42:
challenging [1] 97:2 48:7 54:2,11,20 55:4 66:22 69:11, clinically [3] 47:10 140:5,10 22 85:15,17 93:6 94:17 95:21 100:
Chalmers [1] 297:8 22 74:5 76:16 88:4 108:17 110:16, clinician [1] 265:14 2 105:19 122:4 155:22 162:18
chance [4] 45:9 65:21 145:1 157:9 17,17,18 111:2,3 114:1 124:20 clinicians [1] 166:11 165:19 169:21 203:7 208:18 219:
chances [1] 119:9 147:17,22 148:20,21 194:20 195: clinics [1] 88:17 15 226:19 256:4 287:5 296:15
change [18] 29:16 30:6 31:22 46:7 4,8 197:9,22 198:4 201:20,20 203: clock [3] 45:12 54:12 121:8 comes [3] 17:17 37:6 283:15
57:8 67:6 85:20,22 89:7,11 122:2 9,11,18 208:4 209:10,13,15 210:6 close [4] 19:21 20:5 33:21 302:13 comfortable [2] 122:16 226:21
125:5 136:14 140:6 157:4 218:3 212:5 213:14 216:10 218:20 225: closely [1] 85:6 coming [4] 176:3 230:18 273:9
233:19 277:13 17 232:12,14 258:11 263:22 273: closer [2] 33:11 87:9 285:21
changed [4] 95:4 170:13 206:18 8,9 274:17 clotting [2] 23:14,16 commend [1] 190:12
255:18 cirrhotic [12] 45:11 48:1 54:15 93: clue [1] 212:12 comment [16] 9:6 114:6 145:18
changes [10] 19:15 31:4 33:7 47: 4 136:16 145:22 152:3 153:19 cluster [1] 69:18 155:7,14 167:21 205:11 216:7
19 67:4 68:17 113:10,20 140:10 168:19 209:20,21 270:9 Cmax [1] 277:8 218:7 219:17 234:20 250:10 251:
277:10 cirrhotics [10] 78:20 80:17 88:10 Cmin [1] 164:3 12 284:5 292:5 312:5
changing [4] 63:5,6 234:13,14 137:18 150:10 153:12 208:12 222: co-chair [1] 186:19 commentary [4] 172:2,8 196:18
characteristic [2] 56:21 182:5 3 224:11 226:2 co-factors [1] 114:1 232:10
characteristics [4] 18:7 109:16 cited [1] 125:20 co-infected [15] 189:3,5 231:21 commented [3] 119:18 127:18
130:19 180:22 cities [4] 87:4,5,7 97:20 240:12,15 260:21 261:15 262:8, 230:9
characterizations [1] 96:1 City [4] 5:5 87:3,10 98:4 10 266:8 267:5 268:10 271:13 commenting [1] 12:6
characterize [6] 98:16 102:9,20 claimed [1] 25:6 272:5 310:7 comments [13] 153:2 158:3 191:1
230:2,13 261:7 clarification [5] 142:14 155:7 157: co-infection [6] 221:16 258:18 223:21 233:16 243:22 244:1 268:
characterized [10] 22:22 58:7 66: 11 271:3 272:15 262:1,2,13 271:21 1,7 273:12 283:2 288:2 292:3
22 177:5,8 191:19 193:17,20 219: clarifications [1] 142:16 co-infections [2] 187:16,17 commit [1] 221:15
10 236:12 clarify [1] 226:20 co-morbidities [4] 13:12 196:2 commitment [5] 124:7 220:8 221:
characterizes [1] 38:6 clarifying [2] 235:13 236:18 258:3,17 8 230:20 232:2
characterizing [1] 102:3 clarity [2] 155:19 211:14 co-morbidity [1] 188:5 commitments [3] 212:14 230:11
charge [1] 152:15 class [6] 152:4 184:22 268:18 304: co-pilot [1] 167:9 285:4
charges [1] 117:14 3 309:10 310:1 co-primary [1] 123:13 committed [1] 177:21
chief [1] 180:7 classes [2] 185:6 276:15 cocaine [1] 24:17 COMMITTEE [52] 1:4 3:4 4:4,6,18
Child [4] 128:15 129:1,7 287:2 classification [2] 18:9 19:16 cocktail [1] 81:22 6:20 7:6,10 8:11,17 9:18,20 64:13
child=s [1] 293:14 clear [31] 20:7 22:12 33:18,22 38:3 cohort [4] 73:6 111:15 153:22 217: 106:11 117:14 121:15 138:20 140:
children [24] 24:1 45:3 154:12 286: 39:11,12 40:20 53:3 55:16 56:13, 4 9 142:11 171:10 172:15,21 173:7
2,3,6,7,9,12 287:15,18 288:10 290: 22 57:19 58:17 68:8 72:3 101:12 cohorts [3] 104:8,10 105:6 178:8,12 179:4 180:17 184:21
17 291:3,5,7,21 292:17,21 293:9 109:17 180:19 182:2,6,17 184:20 coincide [1] 58:11 185:5,13,21 186:6,9,20 187:4 189:
294:19 295:1,7,8 185:5 244:15 254:10 270:5,14 coinfected [21] 34:13 35:6 36:5, 6 190:9 192:10 196:20 197:4 232:
choices [3] 251:22 281:17 298:12 294:5 297:21 301:1 18 37:2,11 38:1 46:13 72:22 73: 8 243:8 244:1,16 246:9 249:10
cholestatic [1] 284:9 clear-cut [1] 237:8 10 76:14 78:11 92:1,4 93:3 98:6 257:11 270:2 273:12 283:3 288:3
cholesterol [1] 104:13 clearance [54] 28:13,14 29:15 30: 99:5,20 115:6 136:17 137:22 309:6
choose [4] 173:8 207:8,8 269:14 8,12,15 32:1,3,5,6,7,8,10 34:6,21 coinfection [23] 46:4 72:19 84:18, committee-wide [1] 142:17
chosen [1] 42:13 37:10,14,21 40:11 43:8,8,12,22 20 87:13,16,19 88:15,21 89:2,6,8, committee=s [5] 7:1 175:21 176:
Chronic [38] 3:15 6:22 10:20 17: 51:9 53:11 57:5,10,17 58:8,13 64: 12 97:15 98:20 99:13 100:1 104:9, 15 181:7 232:11
16,21 18:2 21:7 22:12 23:19 25: 1 81:1 82:6 120:5,6,12 121:3 122: 12,17 112:8,14 114:2 committees [1] 185:5
19 26:14 27:5 28:16 50:13 51:1 21 124:9 144:1 161:21 163:1,5,5, coinfectionB-I [1] 104:15 common [8] 10:22 20:8,18 75:20
53:14 76:22 80:20 82:2 106:19 9 169:3 183:19,22 184:1,16 253:3 coli [1] 251:4 109:4 187:10 247:20 268:14
108:22 109:3 110:6,14 118:7 129: 286:17 299:15 301:1 collaborating [1] 105:11 commonly [4] 21:19 44:21 120:19

Sheet 5 centers - commonly
260:17 compounded [1] 246:11 8 83:6 101:11 165:4 188:16 233: Corporation [1] 174:3
communications [2] 4:10,12 comprised [1] 66:11 15 276:2,13 correct [8] 124:7 155:14,17 156:5
communities [2] 98:22,22 compromise [1] 216:18 considerations [2] 78:13 246:1 162:20 220:10 245:3 270:6
Community [23] 3:20 15:17 44:21 compromises [1] 156:2 considered [12] 40:21 76:6 80:13 correction [1] 19:9
75:16 80:11 83:19,20 84:16 86:6, concentrate [1] 175:11 121:2 125:7,12,19 133:18 134:1 correlations [1] 101:21
8,21 87:6 95:7 102:11 105:17 112: concept [7] 27:15 38:16 63:10 138:19 189:12 257:17 correspondingly [1] 243:4
11 185:20 186:18 187:5 234:12 114:20 161:14 194:5,6 considering [4] 91:4 98:14 100: cost [4] 11:20 49:4 81:17 217:7
274:20 275:22 312:13 conceptualize [1] 208:22 19 110:7 costs [5] 48:18 49:6,6,16,17
community-based [1] 88:18 concern [15] 103:12,16,18 118:18 consistent [1] 12:4 couldn=t [1] 213:15
companies [19] 44:10 85:3,11 90: 121:11 130:9 135:4,7 210:16,20 consolidated [1] 63:20 counseling [1] 24:14
12 92:8,20 93:11 96:16 97:3 105: 228:20 234:12 259:4 277:15 290: consortium [2] 105:8,12 counterbalancing [1] 90:10
9,16 176:22 177:21 182:21 257:1 10 constant [8] 28:2 30:14,15 43:8,9, counterpoint [1] 151:4
269:18 289:2 296:1 300:9 concerned [8] 130:12 132:5 178:3 17 57:17,18 country [14] 34:11 86:6 87:2,9 109:
company [6] 8:18 172:22 180:8 188:21 190:5 206:22 230:22 235: constitute [1] 257:13 5 199:4 202:5 204:4,8,12 306:9,
214:20,22 246:4 22 constituted [1] 115:18 15,18 309:12
company=s [2] 173:3 177:15 concerning [2] 14:13 64:21 constitutes [2] 176:5 245:1 county [1] 194:19
comparability [1] 79:9 concerns [16] 82:17 134:20 135:8 constrained [1] 225:3 couple [12] 48:4 85:3,10 89:19 90:
comparator [4] 36:10 117:18 131: 181:9 189:11 211:7 232:17 244:4, constructive [1] 180:18 10 103:9 176:22 190:22 191:10
22 139:5 7,14,19 259:17 260:1 292:9 308:3 CONSULTANT [1] 2:19 192:10 287:21 290:9
compare [2] 121:13 200:22 311:1 CONSULTANTS [2] 2:13 309:19 course [22] 25:18 39:12 59:9 76:
compared [14] 55:14 59:22 69:4 concludes [2] 142:3 196:17 consumed [1] 276:9 22 115:8 116:14 130:22 149:7
73:18 117:17 132:15 134:8 163:7 concluding [2] 108:4 137:14 Consumer [2] 2:9 16:11 150:22 160:2 168:7 183:12,18
183:7 252:19 265:19 286:8,14 conclusion [2] 23:6 230:19 contact [1] 27:18 192:6 201:11,13 210:2 221:10
298:2 concomitant [2] 259:11,20 contacted [2] 106:19 198:10 227:2 237:17 252:12 282:17
comparison [4] 36:11,16 68:4 concur [1] 118:12 contain [3] 13:9 67:12 89:5 cover [4] 84:4 120:4 202:17 266:
152:8 Concurrent [1] 134:11 contend [1] 58:17 22
comparisons [2] 38:7 165:22 concurrently [1] 225:9 contended [1] 277:7 coverage [5] 86:17 182:5,12 234:
compartment [2] 43:20 160:7 condensing [1] 64:14 content [1] 230:2 13,13
compartmentalization [1] 144:3 condition [1] 145:11 context [10] 164:7 172:16 209:12 crafty [1] 60:21
compassionate [2] 222:18 223:3 conduct [2] 138:22 191:4 256:13 263:22 264:2 269:9 294: create [3] 39:17 101:6 210:22
compelling [3] 87:19,20 197:20 conducted [2] 157:16 267:18 21,22 295:2 created [3] 39:15 41:11 178:5
compensated [30] 13:9 54:22 conducting [1] 243:20 continue [13] 40:4 66:1 68:6 131: creates [3] 37:20 38:10 88:6
110:13,16,16,17 111:7 113:22 confer [1] 166:17 3 137:3 157:7 159:12 188:18 189: Crippen [1] 151:6
118:6 120:2 126:6 137:17 147:18, conference [2] 86:16 150:5 18 190:8,14 221:1 296:12 criteria [8] 26:17 138:18 150:18
22 197:8 202:20 203:5,9,17 208: conferences [1] 86:18 continuing [3] 45:8 112:10 167:1 175:13 176:20 189:3 269:1 279:
11 209:13,20 213:4 216:9 217:22 confidence [6] 135:15 141:9,10 continuous [1] 308:15 13
224:11 228:4 231:17 232:12 285: 162:8 166:7 216:14 contra [2] 56:16,18 critical [3] 50:5 226:9 264:9
10 confident [2] 122:5 191:8 contradiction [1] 187:14 criticize [1] 95:12
competition [1] 132:15 confine [2] 111:20 247:6 contraindicated [3] 127:12 134: crop [1] 257:20
complementary [2] 133:22 185:8 confined [2] 91:14 117:6 20 140:21 cross-inhibit [1] 56:15
complete [6] 32:15 149:17 150:22 confirm [2] 116:8 121:22 contraindication [1] 79:8 cross-resistance [4] 96:1 102:10,
167:7 204:15 239:12 confirmation [1] 25:9 contraindications [1] 75:5 13,21
completed [4] 211:15,18 243:10 Confirmed [1] 24:7 contrast [2] 71:11 184:6 crossover [1] 118:13
284:1 Conflict [5] 3:5 6:12,13,15 9:8 contravene [1] 63:2 crucial [3] 51:13 94:6 299:13
completely [11] 62:16 78:17 122:5 conflicts [5] 7:14 8:9,11 173:20 contribute [1] 243:17 crushable [1] 291:8
151:15 223:18 225:18 228:17 231: 191:9 contributor [1] 24:12 crushed [1] 291:9
3 237:6 286:18 297:7 confusion [1] 120:5 control [11] 7:3 14:1 79:16 118:8 crystalize [1] 223:22
completing [1] 216:2 congruity [2] 107:4 130:6 119:3,20 134:10 143:6 144:4 150: CTP [1] 140:7
completion [3] 159:13 160:8 270: connection [1] 173:4 2,3 CTPA [1] 152:4
12 consensus [10] 107:20 110:3 118: controlled [4] 78:17 79:6 105:1 cure [6] 37:21 50:22 84:18 91:18
complex [7] 10:9 16:21 31:1,15 7 131:18 143:21 226:15 232:11 218:13 99:15 101:7
164:18 166:5 186:7 246:8 273:4 275:21 controls [7] 12:20 13:20,21 42:14 cured [6] 51:3 84:20 100:11 104:
complexity [3] 171:2 181:4 281: consent [1] 213:17 118:5 139:4 192:15 21 176:4 231:7
16 consequence [1] 144:10 controversial [2] 32:21 110:11 curiosity [1] 117:2
compliance [7] 65:3,14 116:4,7 consequences [3] 110:19 205:1 controversies [1] 51:21 current [19] 9:4 43:22 89:3 109:7
253:15 310:15,17 242:17 controversy [3] 58:10 100:9 244: 113:14 143:2,10,15 147:6 156:17
compliant [1] 70:22 Consequently [3] 64:19 146:7 4 157:2 160:22 166:16 184:14 189:
complicated [2] 203:3 221:4 289:22 conundrum [2] 55:14 288:21 14,18 207:13 290:13 312:10
complication [1] 167:8 consider [28] 68:2 88:7 90:22 91: conundrums [1] 82:21 Currently [14] 11:9 35:20 65:2 79:
complications [6] 49:11 88:4 108: 3 93:8,13 95:2 96:6 99:6,9 100:10 conversation [2] 187:5 264:14 3 82:20 122:10,16 123:21 138:17
22 126:18 187:12 206:8 101:3 103:12 129:7 158:5 170:7 Conversion [1] 68:13 186:20 217:12 247:3 291:16,17
comply [1] 249:19 178:12 183:13 187:4 188:13 192: convert [1] 182:14 curve [6] 32:18 36:11,22 37:1 169:
component [1] 60:7 10 195:3 229:2 246:5 253:20 280: convinced [1] 297:14 17 183:11
components [1] 66:11 14 294:2 308:18 copies [2] 8:4 120:21 cutoff [1] 166:9
composite [1] 129:13 considerable [2] 40:5 109:12 core [1] 18:19 cutoffs [1] 41:12
compound [1] 210:12 consideration [11] 70:1 78:3 81:3, corner [2] 110:5 246:20 cutting [1] 96:18

Sheet 6 commonly - cutting
cyclosporin [1] 12:9 decade [2] 48:17 174:12 degrees [1] 194:8 detectability [2] 34:22 144:22
CYP [1] 230:5 decades [2] 27:12 293:18 dehydrogenase [1] 62:10 detectable [2] 116:3 161:3
cytochrome [4] 227:15 259:6 261: deceased [1] 152:9 delay [8] 118:15 119:3,20 206:9 detection [1] 63:12
20 268:16 decide [1] 40:3 230:15 243:5 260:8 288:22 deterioration [1] 204:4
cytokine [5] 56:3,17 57:8 63:5 170: decided [1] 140:4 delayed [1] 177:12 determination [1] 157:15
17 decision [6] 25:4 165:5 166:12 deleterious [2] 209:8 242:16 determinations [1] 166:20
cytokines [4] 53:1 56:10,14 63:3 200:5 219:19 246:1 deliberate [1] 229:3 determine [2] 41:19 172:7
cytopathic [1] 52:15 decision-making [1] 172:13 deliberations [1] 7:2 determined [2] 64:16 303:1
cytoplasmic [1] 144:10 decisions [1] 24:20 delineating [1] 303:6 determining [1] 20:5
cytotoxic [4] 55:12 57:7,9,15 decline [14] 31:17,19 32:17,19 33:delivered [1] 292:14 devastating [1] 112:9
12,15 34:5 36:11,22 164:18 165:9, demand [1] 294:13 develop [19] 22:12 29:9,12 37:13
D 9 169:17 183:18 demanding [1] 294:14 45:12 48:5 50:21 55:22 74:5 90:8
daily [6] 58:3 135:4 163:15 164:6, declines [2] 159:21,22 demographics [1] 188:2 128:14 164:13,16 165:11,13 166:
12,15 declining [1] 35:22 demonstrate [4] 133:12 137:9 11 182:14 206:21 215:1
damage [1] 110:9 decompensate [1] 74:8 142:1 257:8 developed [5] 39:20 128:17 140:1
danger [1] 264:19 decompensated [70] 13:10 49:15 demonstrated [8] 18:12 28:17 38: 206:10 246:21
dangerous [6] 208:3 209:1,5 212: 76:16 78:20 80:4,17 111:2,8,9 9 110:21 112:20 115:2 132:12 developers [2] 185:3,12
20 213:18 219:6 115:9 119:19 120:3 126:3,8,10 140:20 developing [5] 164:17 168:20 169:
dark [1] 104:3 127:10,13,20 128:15 134:16 145: demonstration [1] 58:15 22 182:21 290:14
data [108] 13:9,13,15 17:15 21:14 7 150:8 151:9,11 153:18 197:9,22 DEPARTMENT [1] 1:1 Development [39] 3:8 5:22 6:21 9:
23:3 28:17 29:6 33:17 34:9,10 39: 198:3 202:21 203:2,22 204:2,20 departments [1] 87:4 12,14 10:12 11:4 12:14 21:9 45:
16,19 40:1 41:1,2 43:3 64:14 66:7 206:15 208:3,12 209:9,14 210:5 depend [2] 263:12 285:4 16 51:15 72:17 80:12 90:14,22 91:
68:19 70:16 71:1,13 74:10 77:16 212:5 213:4,14 218:20 219:6,20 dependent [2] 14:12 15:8 2 96:21 103:5 114:22 117:7 130:
80:15 90:16 91:8,8,12,19 93:1,7 220:12,13 224:3,7,7 225:4,17 226: Depending [13] 44:22 56:3 118:10 11 135:6 149:16 180:13 181:4,6
96:2,3,17 97:11 98:6 136:19 138: 1 228:6,22 232:1,14 233:2 258:11 130:18 134:21 172:6 174:14 199: 185:19 186:3 189:13,22 206:7
2 144:12 146:19,21 149:2 154:15 263:22 270:9 273:7,8,19 274:1 11,12 207:17 238:6 251:18 308: 209:7 211:10 232:19 241:9 260:
164:6 167:3,6 168:13 169:8 176:6, 276:1 278:19,22 295:14 298:10 20 19 266:16 300:15,17
10,12 177:12 182:13 205:22 206: decompensatedB-it [1] 126:1 depends [3] 14:3 97:19 218:22 developments [2] 83:9 241:21
3,5,6 208:11 211:16 212:9,11,17 decompensation [15] 48:2 54:14 Deputy [1] 6:7 develops [1] 190:7
215:2 217:3 218:12,20 225:22 55:2 79:7 80:1 88:11 93:4 127:15 derive [1] 42:6 devices [1] 4:11
226:22 227:1,5,10,11,12,14,16,17, 150:13 151:10 195:5 217:5 218:2 derived [5] 22:20 41:2 58:2 170:9 devil=s [2] 207:2 248:1
18 229:4,10,17 230:5 234:6 243: 225:5 274:19 228:4 Di [1] 44:20
10 246:21 260:3,10 261:13,14 decrease [2] 49:16 61:14 describe [1] 191:8 diabetes [2] 104:12 188:10
262:20 263:3,6,9,13,18,20 264:1, decreased [4] 34:2 56:16,17 128: described [1] 210:2 dialysis [2] 80:21 311:9
10 267:2 271:6,20 288:17 292:1 7 describing [3] 32:19 251:18 253: dictating [1] 72:14
294:1 305:12,14,19 decreases [1] 49:14 22 didn=t [11] 38:2,18,20 42:22 122:4
dataB-we [1] 271:6 decreasing [5] 61:10 108:13 124: deserve [1] 194:3 126:14 135:20 146:15 213:22 259:
database [2] 74:11 146:2 19 166:17,18 deserves [3] 106:16 199:22 276: 17 296:13
databases [3] 97:8,12 105:20 decrement [1] 71:10 13 die [7] 27:21 28:6 45:17 213:14,19
date [4] 144:12 169:14 257:2 291: deeper [1] 186:6 Design [42] 3:14 6:21 12:18,21 14: 215:7 231:20
13 deeply [2] 155:18 161:12 1 15:15 50:9,12 51:13,20 66:12 Diego [1] 5:13
David [2] 3:29 180:7 defensible [1] 252:14 88:7 92:12,16,19 95:2 96:15 103: difference [26] 33:10 36:20 37:8
Davis [1] 49:11 defer [2] 167:2 288:11 10 105:17 129:18,20 130:4 140: 42:11,14 52:8,22 53:1 54:2 117:5
Davis= [1] 41:2 deferred [4] 14:2 118:12 134:9 14 145:15 191:4 209:16 215:6 119:2 121:7 128:21 144:20 182:9
day [6] 10:10 19:6 197:13 258:7 139:6 224:10 225:3 228:7 239:11 253: 213:2 214:13 219:3 234:15 253:
287:19 312:4 deficits [2] 72:12 136:17 17 254:3,3,5 255:20 267:17 276: 19 277:6 287:4 294:6 301:7 303:
days [15] 33:9,21 34:2,4,15,18,22 define [13] 26:4 64:11 65:1,2 92:9 12 278:2 279:12 280:18 282:19 11 305:20
35:1 36:13 38:17 58:16 92:14 133: 93:21 178:9,10 236:6 243:3 252:5 designated [1] 5:9 differences [9] 21:3 34:4 53:3,20
14 191:11 282:15 253:9 281:8 designed [8] 157:20 225:9 248:3 71:17,19 143:9 219:5 306:13
dead [1] 216:21 defined [11] 26:14 37:20 55:9 56:8 250:17,21 257:12 267:21 311:4 different [72] 19:20,20 20:1,17 33:
deal [11] 42:18 95:10 175:2 188:7 95:22 120:19,20 123:7 147:2 150: designing [3] 88:7 251:11 274:3 17 36:17 38:8,8,11 41:22 42:16,
189:4 192:7,9 222:21 231:14 235: 18 277:9 designs [13] 14:7,10 59:5 75:17 17 43:21 69:16 85:19 93:16,19,22
3 307:10 defines [1] 21:22 77:4,18 79:5 80:16 105:11 167:1 99:12,21 114:12 116:17 119:10
dealing [9] 49:7 134:14 155:1 205: defining [4] 64:5 158:12 236:10 185:14 309:8 311:19 132:11 133:10 140:1 145:13,16
7 230:21 231:13 233:12 235:6 252:3 desirability [1] 143:22 147:5 151:14,16 162:17,21 179:
273:2 definite [1] 200:5 desirable [2] 167:17 219:9 18,19 181:11,13 183:6 188:5,14,
deals [1] 195:18 definitely [2] 245:7 306:4 desire [1] 218:10 15 207:12 208:2,5 221:12 223:17
dealt [4] 95:11 114:19 199:17 303: definition [8] 47:7 77:22 115:12, desires [1] 242:5 226:12 238:12,15,22 239:8,10,11
8 14 116:6 121:4 130:14 160:12 desk [1] 172:3 240:6 245:21 247:10 265:18,20
death [11] 17:15 43:16 73:9 97:18, definitional [1] 117:1 desperate [1] 219:3 277:12 279:1 287:12 294:7 295:
22 98:3 187:11 213:22 218:4 220: definitions [6] 107:21 110:3,4,7 desperately [1] 214:18 13,13 297:22 298:3 299:9 300:22
2 230:8 116:13 159:11 despite [2] 65:3 100:8 301:2 309:18,20 310:11
deaths [8] 10:21 22:6,14 49:1 73:8 definitive [4] 44:16 123:16 177:12 destined [1] 152:16 differential [10] 29:12 37:10 69:7
228:13,16 261:5 268:22 detail [3] 156:10 168:3 191:8 117:13 138:22 139:8 158:8 164:
debate [3] 77:7,20 228:8 degree [5] 27:6 125:12 154:5 166: details [1] 263:7 14,21 266:3
debated [2] 62:17 63:21 7 268:21 detect [1] 305:3 differentiated [3] 116:18 120:2
Debra [5] 2:22 3:9 6:9 9:10 21:6
Sheet 7 cyclosporin - differentiated
122:22 196:14 197:8 199:16 200:14 202: 224:15 230:15 231:12 233:18 242: 15 189:7 190:5 197:21 205:19,20
differently [4] 42:3 98:14 117:8 16 203:2,16,17 204:5 212:6 218:3 7 244:9 245:5,9,19 249:22 251:3 209:6 212:12 217:21 218:22 221:
304:18 219:20 222:4 223:10 228:4,6 230: 253:10 254:4 256:14 258:7 260: 5 222:7 223:4 224:18 227:20 230:
differing [3] 107:8 121:12 133:9 7,9,21 231:10,14,21 232:1 233:2 11 261:4 264:5 270:11 271:16 7,15 231:4 233:1,3,4 234:16,17
differs [1] 72:22 265:6 274:8 276:1,8 279:17 280:5 277:14,19 278:14 282:20 283:12, 239:21 241:8,20 242:3 245:8 247:
difficult [35] 90:7 92:17 114:10 285:10,13,14 286:10,14 292:21 22 285:4,7 288:17,21 289:1,18 17 249:1,5,15 250:20 252:16,18
115:4,15 134:1 143:13 144:18 293:5 298:11,14,20 300:7,22 306: 290:8 293:5 294:17 297:10,13 255:14,15 259:18 260:19 261:3,
174:17 178:19 187:13 189:17 192: 21 309:11 311:2,18 299:6,7 300:1,21 304:12,13 305:6 16 263:21 264:17,19,22 265:20
11 193:14 201:6 218:8 219:13 diseased [1] 153:17 310:19 311:12 312:7 267:9 268:11 269:2,9,13,17 270:
220:22 221:4 224:5 237:16 244:6 Diseases [12] 3:18 5:2,7,12,15 16: donated [1] 276:11 17 277:2,13,16 278:6 283:5 285:8
252:2,5,7,8 262:9 272:13 275:19 14 51:5 55:15 76:21 87:15,18 95: donation [1] 204:10 288:18,22 289:2,3,16 294:10 296:
280:17 281:19,20 283:8,19 309: 5 done [51] 4:8 39:16 67:16 68:10 9 297:10,18 299:12,12,14 300:15,
15 disorders [2] 312:11,17 73:14 77:3 122:7 133:15 136:6 16 301:6,6,9,9,12,14 304:2 311:5
Difficulties [4] 3:14 15:16 50:9,12 disparate [1] 114:15 170:8 175:16 192:22 194:11 197: 312:10,16
dig [1] 186:6 disparities [1] 73:19 10 199:8 200:21 204:2 206:13 drug-drug [4] 259:5 260:3,16 277:
Digestive [1] 3:18 disparity [3] 72:7 107:5 204:9 221:7 222:9,13 226:8 236:21 237: 9
direct [6] 49:5 62:22 159:21 160:5 disproportionate [1] 307:11 18 247:15,21 256:9 258:21 260: drug-suppressed [1] 162:1
183:13 241:8 dissolution [1] 51:3 18 261:6 264:22 270:19 276:18 Drug-to-drug [2] 133:17 187:21
directing [1] 77:6 dissolve [1] 61:18 280:6 283:7,14,16,21,21 285:5,5 drug=s [1] 198:2
direction [2] 302:2 303:18 distinct [3] 153:21 192:19 235:20 296:15 297:2,12 298:7 306:1,3,5 DRUGS [99] 1:4 3:4 4:4 11:4 19:1
directions [1] 122:2 distinction [3] 184:20 237:7 251: 309:18 311:21 312:18 23:14 30:19 32:11 55:22 60:1 69:
directly [2] 22:14 184:22 22 donor [4] 152:9,9 214:13 223:9 8 89:16 90:7,8,12,14 91:3,7 93:2,
Director [7] 3:10,18 6:8,10 16:8, distinctions [1] 186:2 dormant [1] 144:11 9,13 95:21 96:14,22 97:9 102:4,
13 83:17 distinctly [2] 236:9,22 dose [19] 14:17 71:2,8,8 78:5 131: 21 105:10,19 133:18 138:16 142:
Director/Founder [1] 3:21 distribute [1] 245:20 10 150:15,15,21 178:22 223:4 1 143:8 151:14,16 160:17 170:12,
disagree [1] 203:21 distribution [1] 20:16 255:7,12,22 256:4,12 278:16 299: 18 174:22 175:13 179:18 181:8
disappeared [2] 149:14 159:2 divergence [2] 20:9,22 11,17 188:15 189:12 195:12 199:19 205:
disclaim [1] 52:1 divergent [1] 119:15 dose-response [1] 163:22 15 206:21 207:1,3,22 219:1,4,10
disclose [1] 8:13 diverse [1] 188:20 doses [5] 73:21 150:16 184:17 221:2,13 223:16 227:14 239:2,4
disclosure [1] 180:6 divide [1] 215:16 275:16 301:9 240:20 241:12,13,18 242:6 245:5
discontinuation [1] 73:20 divided [2] 113:7 236:15 dosing [4] 69:8 81:5 170:22 191: 250:17,19 251:6,11 256:4,22 257:
discounting [1] 144:15 Division [12] 3:10,18,25 6:6,9,10 21 11,20 260:17,20,22 263:1 265:18
discovered [1] 198:9 121:6 130:10 132:22 135:8 186:4, dossier [1] 177:4 266:16 268:13,13,14 272:20 282:
discovery [2] 169:7 224:13 5 dots [1] 34:19 4 284:2 285:6,20 288:20 289:21,
discretion [1] 24:6 doable [1] 201:3 double [2] 48:22 87:10 22 290:21 291:3 293:11 295:4,8
discuss [14] 4:5 6:20 7:2 12:14 37: dockets [1] 8:1 doubt [1] 97:16 299:4,16 301:2
12 53:14 64:12 142:18 143:5 146: doctors [1] 102:12 Doug [2] 7:20 261:19 dual [1] 57:22
20 155:21 157:13 178:8 205:12 doctors= [1] 126:6 Douglas [2] 2:6 5:14 due [10] 58:4 74:15 76:20 82:22
discussed [17] 7:7 21:2 78:13 94: document [1] 191:10 down [14] 26:12 31:8 33:12,15 34: 127:13 204:4,22 231:5 276:1,8
3 98:18 144:14 151:21 190:3 197: documented [4] 76:5,9 116:4,7 2,3 42:22 101:7 165:19 169:11 durability [3] 100:4 135:15 141:13
3 234:22 246:19 258:12 273:11, documents [1] 7:22 263:5 285:21 297:6 300:14 durable [4] 64:7,7 135:18 163:9
18 275:10 277:15 280:11 dodged [1] 146:12 downside [1] 147:18 duration [21] 14:18 39:3 66:20 68:
discussing [7] 10:11 19:2 50:8 84: doesn=t [19] 31:19 38:21 60:12 88: downstream [1] 242:17 16 71:9 73:17 78:15 118:15 119:
7 110:14 235:10 293:6 22 91:13 92:1 158:19 165:17 208: dramatic [3] 48:19 224:10 301:7 10 121:4 131:12 135:10 156:19
discussion [33] 9:16 16:20,21 25: 13 236:17 247:21 248:11 256:13 dramatically [8] 22:5 223:17 226: 170:22 192:20 224:9 251:20 252:
3 40:5 51:7 52:4 74:20 77:6 82:18 257:3 297:11 298:13 301:12 309: 12 297:22 298:3 299:9 300:22 10,11,20 255:3
97:17 139:14 150:4 154:10 155:6 16,18 301:2 durations [4] 119:2 121:12 139:7
156:8 157:10 159:20 162:13 163: doing [24] 32:21 63:1 94:15 96:13 drift [2] 19:10,10 160:11
11 170:5 196:20 229:22 233:21 103:16 128:9 137:10 142:9 154:7 driven [1] 242:4 during [7] 4:12 32:2 39:9 160:2
241:5 258:8,13 264:2 272:4 298:9, 177:21 178:17 201:12 220:20 241: drop [11] 26:11 30:10 33:13 35:11 181:5 183:12 185:6
10 302:1,19 14 253:9 254:17 255:11 256:18 40:17 55:2 58:4 63:16 70:9 165: dying [2] 102:18 217:12
discussions [11] 8:10,20 15:20 262:3 278:6 281:19 301:15 304: 19 282:14 dynamic [3] 28:7 45:8 55:20
17:2 26:21 106:11 174:8 180:18 21 307:3 dropout [1] 310:10 dynamics [6] 27:15 158:15 180:20
234:22 263:12 302:4 dollars [2] 49:7 88:16 dropped [1] 22:5 224:18 227:6,9
disease [116] 5:17 17:17,21 18:3 dominate [1] 66:15 dropping [1] 165:14
23:9,20 24:13 28:22 29:2 45:11, don=t [109] 31:21 39:1,1,5 41:4,10 drove [1] 298:9
E
13,15 46:16 47:21 48:3 49:15 50: 43:17 46:21 53:22 79:9 84:7 92:9, Drs [1] 7:18 each [20] 7:15 10:18 19:22 20:5 35:
21 51:2 52:9,16 56:22 66:20 73:8 19 94:7,22 95:12 96:20,22 97:15 DRUG [140] 1:2,3 3:8 6:19 7:16 9: 5 56:15 129:19 133:12 172:1 197:
74:15 77:1 78:22 82:10 89:17,18, 99:7,15 101:4 102:4 103:19 104:3 12,14 10:11 12:14 24:18 31:20 42: 6 201:2 206:4 230:3 241:6 246:20
21 90:3 101:14 108:12,15,16,19 110:10 111:3 132:8 136:7,19 139: 7,8 59:10 70:22 72:16 77:9 78:7 293:22 295:19 296:1,16 305:3
110:13,19 111:7 112:4,4,9 113:22 20 143:3 145:4,8 146:13 147:4,15 80:12 85:3,4 90:22 91:1,8,9 92:5 eaerlier [1] 121:18
119:19 120:2 124:11,20 126:4,6,8 153:9 155:17 157:4 164:12,20 93:6,10 94:5,11,14,21 95:15,18 earlier [30] 43:16 55:8 69:9 108:21
127:7,10 128:17 135:12 136:4 165:11,12 168:15 176:12 177:10 96:13 97:5 98:7 99:1 103:6 105:9, 109:1 116:15 118:19 123:6 125:9
137:17 143:11 144:5 151:19 162: 178:6 191:7 193:9 194:9 195:7 18 115:1 118:16 138:12 155:2 126:11 134:6 135:11 153:19 154:
4 163:6 174:14 175:1 180:11 181: 197:19,19 198:11 202:5 207:10 162:10 164:4,9 165:21,22 169:7 12 159:20 181:22 187:7,15 235:
14 183:3 184:7 187:10 194:14,14 214:3,14 220:17 221:12 223:8 172:11 185:3,6,12,19 186:3 187: 16 236:11 259:1,5 265:6 270:9
292:20 298:10,21 306:8,14 312:
Sheet 8 differentiated - earlier
12 element [3] 211:22 224:21 248:5 enhance [2] 183:1 309:21 estimate [4] 22:6 23:6 86:13 307:
earliest [3] 70:12 80:14 189:1 elements [3] 55:1 59:13 142:13 enhancement [1] 184:12 8
early [56] 26:8 29:11 31:3 32:13 34: elevated [4] 53:21 54:16 75:3,19 enjoy [2] 145:10 161:11 estimated [3] 22:7 48:15 49:4
5 35:17,17 36:21,22,22 38:17 43: ELI [1] 181:19 enlarging [1] 225:1 estimates [7] 10:18 22:13,20 23:5
11 44:2 63:17 64:10 65:7,18 70: elicit [1] 181:21 enough [10] 40:8 67:12 124:11 48:19 54:17 64:8
10 72:3 97:6 98:16 102:14 113:9 eligible [2] 253:20 279:18 126:8 144:21 205:21 227:17 233: etc [8] 151:17 168:9 220:15 221:18,
123:16 149:17 154:18 160:4,14 eliminate [4] 23:17 81:14 100:16 9 261:2 264:6 18 266:22 296:4,4
166:1 168:1,10 169:7 170:15 174: 176:17 enroll [5] 84:19 114:10 115:5 241: ethical [1] 215:14
14 176:11 179:1,14 183:18 187: eliminated [2] 84:22 162:9 1 305:22 ethically [1] 214:5
18,21 192:17,18 217:10 232:19 ELISA [1] 26:7 enrolled [5] 13:1 259:16,19 291: ethics [4] 214:6,8,8 241:14
233:2,5 241:18,20 259:3,19 260: eloquently [1] 302:7 22 306:3 ethnic [12] 13:18 76:12 112:20
18 262:14 268:9,18 282:8 286:19 elsewhere [1] 144:6 enrolling [1] 246:12 188:20 258:15 301:22 302:4 303:
ease [1] 253:16 elucidate [1] 154:11 enrollment [4] 115:18 291:22 309: 19 304:1 307:16 311:1,17
easier [8] 201:4 238:7 241:1 249:1, email [1] 86:12 2 310:9 etiology [2] 17:21 21:12
14,15,19 296:10 embark [1] 50:4 ensure [3] 172:14 189:21 267:19 ETR [1] 76:8
easiest [6] 201:21 202:1 221:22 embraced [1] 143:21 ensuring [1] 308:19 Eugene [3] 2:10 5:22 8:14
264:15,18 297:17 emerge [1] 118:17 enter [1] 259:9 evaluate [2] 150:10 192:20
easily [6] 206:10 212:22 234:1 251: emergence [3] 26:5 235:7 267:11 entering [3] 50:1 62:7 174:18 evaluate-Band [1] 30:22
20 290:22 291:7 emergency [2] 24:1,8 entertain [1] 77:4 evaluated [2] 267:12 312:1
easy [4] 200:20 225:21 249:22 264: emerging [1] 82:20 entertained [1] 77:5 evaluating [2] 101:14 211:1
4 emphasis [1] 101:17 entertainment [1] 204:1 EVALUATION [8] 1:3 6:19 25:13
ebb [2] 282:11,12 emphasize [1] 102:2 enthusiasm [2] 131:19 141:6 155:9,12 158:5 267:8 268:15
echo [1] 158:3 emphasizes [1] 66:8 entire [1] 111:21 Evelyn [1] 307:6
edges [1] 67:22 emphasizing [1] 18:4 entirely [1] 248:20 even [32] 6:16 11:16 42:16 43:2 47:
Edlin [1] 22:16 employed [2] 124:12 125:2 entry [3] 18:18 300:13 309:21 10 60:18 68:15 84:8 98:20 112:21
education [1] 86:22 employee [1] 8:19 envelope [1] 18:20 117:10,12 120:10 128:3 144:17
educational [1] 86:8 employees [1] 7:18 environment [3] 60:15 62:22 170: 149:13 153:21 186:2 196:8 221:
effect [13] 38:6 61:4 81:6 100:20 employment [1] 189:18 17 17 224:9 228:10 230:6 237:11
104:13 160:6 167:10 170:13 203: empty [1] 280:2 Enzyme [3] 25:5,9 230:5 239:11 247:4,6 249:18 250:5 298:
20 209:8 217:4 290:15 302:12 enable [1] 181:1 enzymes [3] 25:20 26:11,12 16 307:1 308:17
effective [13] 30:20 44:15 49:13 encephalopathy [2] 45:14 110:20 epi [1] 16:19 event [3] 8:20 82:1 210:17
50:22 109:14 190:1 199:19 203:5 encompassed [1] 258:10 epidemic [1] 22:1 events [5] 76:19,20 86:8 87:8 211:
221:14 232:15 275:5 285:9 296: encompassing [1] 250:14 epidemiologic [2] 27:9 245:22 1
11 encouraged [1] 284:12 Epidemiology [5] 3:11 15:13 16:2, eventually [3] 26:5 149:8 165:15
effectiveness [4] 63:6 73:2,5 220: encourages [2] 172:18 173:6 14 17:8 eventuate [1] 274:17
14 encouraging [1] 309:7 epithelial [1] 59:8 Everson [1] 274:10
effects [11] 61:1,3 132:20 153:9 end [23] 18:17 20:11 23:6 30:7 42: epitope [3] 55:9 182:5,12 Everson=s [2] 150:14 151:5
196:2 200:2 222:1 255:16 268:16 8 51:18 54:11 65:7 68:10 76:9 epsilon [7] 31:2,6 33:6,18,20 58: everybody [7] 88:5 92:6 99:15
290:20,20 108:3 116:13 117:11 122:6 147: 16 161:18 138:7 180:5 199:22 206:21
efficacious [6] 33:11 36:13 83:4 20 152:18 163:11 176:8 197:5 equal [5] 66:11 116:2 212:21 251: everyone [18] 17:3,7 46:18 64:18
132:12 229:6,14 223:9 276:1 300:18 308:15 14 286:12 109:8 114:19 120:8 121:2 130:10
efficacy [43] 11:18 31:3 33:5 58:5 end-of-treatment [1] 292:1 equals [2] 28:14 29:15 132:5 175:10 216:10 243:8 244:
80:15 83:1 91:9 93:1 96:7,10,19 end-stage [11] 45:13,15 47:20 48: equation [4] 29:13,17 30:6 31:5 18 257:21 269:2 284:13 312:8
98:6 103:18 104:11 115:2 130:18 3 108:16 124:20 128:16 135:12 equation-based [2] 164:14,22 everything [4] 85:21 105:22 246:3,
145:8 177:5 224:14 228:11 229: 136:3 187:9 311:2 equations [3] 29:10 31:15 42:4 4
12 248:2 251:15 253:2,9 256:1 endeavor [1] 11:5 equilibrium [3] 28:15,15 29:10 evidence [10] 23:20 70:13 110:8,
261:14 267:7 268:19,22 269:1,7 ended [1] 201:1 equivalence [2] 248:18 255:10 19 192:21 194:10 204:19 229:6
271:13 275:3 277:4 285:22 288: ending [1] 200:13 equivalent [6] 249:2 250:3 252:16 246:22 274:11
10,14 303:1,6,7,22 305:3 endorsement [1] 118:20 255:5 256:5 290:19 evident [1] 160:8
efficiency [6] 31:3 33:6,21 34:5 endpoint [28] 47:13 51:21 54:21 era [2] 174:18 250:16 evoke [1] 58:13
35:8 187:22 67:8 77:19 121:1 122:20 124:6 eradicate [1] 124:18 evolve [1] 256:20
efficient [4] 31:20 184:18 205:21 127:17 129:12,13 136:2 139:11, eradication [5] 120:7,10,12 144:2 evolved [1] 39:8
267:16 14 145:19 146:10 155:20 156:21, 175:8 EVR [3] 123:21 165:8 261:15
efficiently [2] 38:12 44:4 22 157:1,4 158:8 159:11 166:20 error [1] 19:9 EVR12 [7] 124:5,14 130:8,14 134:
efforts [4] 192:16 217:9 268:8 311: 238:6,15 239:8,10 errors [1] 44:6 12 139:19 140:16
16 endpoints [46] 7:4 12:21 15:3,5,6 especially [5] 170:18 209:20 222: exact [1] 299:22
eh [1] 78:16 78:8,16 79:17,18 80:18 81:8 82:7, 3 228:17 307:19 exactly [8] 32:2 92:10 132:8 156:
eight [2] 148:4 291:7 8 99:11,12,14,16,18,18,19,20 120: essential [1] 285:3 12 226:21 263:2 271:16 299:19
either [15] 25:11 143:8 144:2 147: 1,4,11,15 121:13 122:19 125:3,16, essentially [10] 83:5 86:20 119:6 example [12] 42:1,4 91:15 105:4
17 148:7 183:2 213:21 232:6 240: 18,19 128:14 129:8 140:3,3 155: 127:2 130:4,21 132:9 176:4 210: 164:1 165:21 173:2 222:19 223:1
6 255:6,7 256:4 259:11 275:16 20 169:1 181:3 185:14 196:4,5 18 253:22 226:1 263:15 285:9
310:19 236:7 238:21 243:4 252:3 308:2 establish [3] 103:17 134:10 269: exceedingly [1] 309:4
elapse [1] 279:2 endpointsB-as [1] 196:6 12 excellent [9] 65:14 67:2 146:16
elect [1] 141:17 ends [1] 53:4 established [3] 27:6 183:3 269:1 156:16 159:4 161:9 171:1 194:6
elects [1] 137:7 engender [1] 82:18 establishment [1] 26:13 203:7
elegantly [1] 183:8 England [1] 153:20 esteemed [1] 186:9 except [7] 52:14 97:19 125:17 135:

Sheet 9 earlier - except
10 140:3 178:11 275:6 extraordinarily [3] 191:18 194:4 feel [20] 4:14 77:10 118:14 122:16 55:3 87:8 92:14 129:19 137:11
exciting [3] 50:2 174:19 181:5 275:20 177:2,3,10,14 179:17 188:6 191:8 141:12 142:1 172:5 175:17 176:2
exclude [2] 179:2 201:5 extrapolated [1] 170:9 212:3 222:5 226:21 244:12 250: 186:12 241:11 288:7 289:5 292:8
excluded [1] 311:3 extremely [8] 19:5 40:19 44:9 50: 13 280:19 291:2 297:14 300:12 297:5
exclusions [1] 9:2 2 55:4 72:20 95:1 160:4 feeling [6] 197:7 222:11 244:11 five-year [1] 126:12
exclusive [3] 56:6,9,14 268:7 285:16 301:17 fixed [6] 37:22 39:14 43:10 45:7
Excuse [1] 203:5
F Feigle [1] 85:14 71:2 157:19
Executive [2] 3:21 83:17 F.A.C.P [1] 3:16 fell [1] 154:21 flat [3] 191:22 193:4 308:3
exhibit [1] 35:14 F4 [1] 69:12 felt [4] 119:15 122:5 136:11,15 flavivirididate [1] 62:13
exist [2] 20:11 44:1 face [2] 102:12 181:5 fences [1] 163:7 flavivirus [1] 62:15
existence [1] 55:4 faced [1] 242:5 Ferenci [1] 70:7 flaviviruses [1] 18:10
existing [1] 52:11 facilities [1] 4:15 few [17] 4:5 26:9 32:18 34:15 44: fleshy [1] 67:21
exogenously [1] 59:10 facing [5] 95:18 236:14 239:21 19 55:16 90:20 119:18 126:2 168: flexibility [2] 208:4,8
expand [1] 81:18 243:15 248:13 16 203:8 231:7 276:10 286:6 287: flip [2] 33:16 163:13
expanded [5] 85:5,11 93:13,18 94: fact [50] 23:7 25:22 27:6 30:11 35: 22 295:1 301:10 flow [3] 47:18,20 195:14
1 1 37:9 38:12 40:19 41:11 43:11 fewer [2] 113:2 200:2 focus [11] 38:15 94:4 111:18 152:
expanding [1] 217:8 57:1 58:19 64:7 67:10 73:13 95:5 fewest [1] 222:1 15 174:3 176:14 181:8 202:3 217:
expect [10] 38:1 107:4 135:20 160: 130:17 149:12,14 150:1,1 151:5 fibrogenesis [6] 52:22 60:19 61: 14 301:19 303:10
13 191:22 225:19 246:4 260:11 152:13 157:22 174:3 175:16 182: 14,15 68:13,18 focused [1] 147:16
287:22 308:12 20 196:11 199:3 207:5 214:11 fibrosing [1] 284:8 focuses [1] 174:20
expectancy [3] 54:22 55:3 276:8 215:14 222:22 223:6,11 231:13 fibrosis [20] 45:20 51:3 53:4 61:10 focusing [3] 114:4 195:20 302:3
expectation [1] 262:22 232:16,21 233:7 235:5 242:19 67:3 69:9,11 128:6 147:16,17,21, folks [3] 136:21 141:1 308:1
expectations [1] 68:15 249:13,19 250:2 256:3 257:12 22 148:20 166:18 167:5 194:8,21 follow [7] 104:8,10 136:12 186:5
expected [1] 238:10 289:14 299:8,10 307:7 195:10 231:18 281:12 261:9 286:6 293:18
expenses [1] 173:4 factor [5] 70:1 194:15 195:9 259:2 fibrotic [2] 46:6 67:20 follow-on [1] 257:19
expensive [1] 109:11 293:6 fidelity [1] 135:5 follow-up [22] 7:5 12:22 80:6,7 82:
Experience [12] 3:14 35:7 50:8,12 factors [13] 23:11,15,16 24:7 46:7,
field [3] 49:22 85:2 155:18 12 100:7 104:1,2 120:22 131:7,8
100:8,10 104:4,18 151:1 220:17 17 61:13 144:16 160:16 221:5 figure [6] 97:3 105:17 133:2 243: 135:14 136:6,8 137:1,6 141:11,16,
236:13 309:20 267:7 286:11 287:3 11 289:8 306:17 18 155:12 156:14 168:1
experienced [16] 13:7 14:5 52:2 fail [3] 43:6,6 137:2 figures [5] 10:15 11:7 147:19 161: followed [6] 15:14 26:22 105:5
140:18 233:11,14 234:5 235:14, failed [1] 116:1 18 162:6 136:19 157:21 168:5
15 238:5,21 244:14 246:17 273:2 failing 14:14
[1]
fill [1] 302:14 following [17] 6:14 7:17 12:7 25:
308:9 310:2 fails [2] 35:13,16 filled [2] 302:9,16 19 27:7 39:16 43:11 45:4 115:14
experienced-patient [1] 239:7 failure [6] 22:6 76:22 80:20 164:2 filling [1] 12:2 154:19 155:9 169:2 171:8,19 172:
experienced-treatment [1] 217: 191:15 194:3 final [2] 167:22 285:7 1 193:2 273:19
22 Fair [1] 233:9 finally [12] 25:13 37:15 73:13 74:2 FOOD [4] 1:2 7:16 172:11 214:14
experimental [3] 207:21 212:4 fairly [8] 17:17 33:10 41:12 160:18 80:20 85:17 179:13 190:9 195:17 forced [1] 275:15
213:16 166:7 231:20 242:20 249:11 258:14 295:17,20 forecast [1] 207:11
expert [1] 198:4 fairness [1] 9:4 financial [7] 7:11 8:22 9:5 172:21 foreign [1] 155:19
expertise [1] 267:19 faith [1] 242:12 173:2,8,9 forever [1] 158:20
explain 29:6 39:19 72:9
[3] fall [2] 25:1 134:17 find [12] 27:5 140:10 179:3 200:15 forget [1] 312:2
explanation [3] 58:18 106:16,17 familiar [2] 142:22 143:3 218:8 219:12 249:13 251:15 254: forgiveness [1] 210:14
expose 133:1
[1] families [2] 290:6 293:9 5 261:12 272:7,11 forgotten [2] 237:20 239:19
exposed [4] 44:22 181:17 182:1, family [3] 62:15 230:5 287:6 finding [4] 47:12 135:19 236:11 form [7] 28:8 62:9,12 106:10 107:2
17 far [13] 74:14 93:17 101:14 113:13 308:15 132:10 257:17
exposure [11] 23:22 24:1 25:19 117:20 193:4 217:16 247:11,15 findings [1] 185:4 Forman [1] 74:10
144:17 164:5 242:13 297:5 299: 273:1 289:11 292:13 296:7 finds [3] 69:17 73:8 74:11 formation [1] 43:10
12 301:6,9,14 fare [1] 76:2 fine [2] 121:20 297:15 former [1] 312:10
exposure-response [5] 163:20 fashion [4] 96:14 205:17 297:12 firm [1] 9:5 forms [1] 19:11
164:9 263:14,17 264:3 300:10 firms [1] 8:21 formula [1] 206:20
express [1] 198:8 fast [5] 85:13 91:3 93:9,12 228:11 First [51] 4:6 32:15,16 34:15,18 35: formulation [3] 290:12 291:4 292:
expressed [2] 135:9 306:7 fastest [3] 113:18 138:5 224:12 18 36:12,12 40:15 51:8 58:3 59: 13
expressing [1] 198:17 fat [1] 47:2 16 67:9 84:12,18,19 86:8 104:16 forth [1] 196:2
expression [1] 61:11 favorable [2] 82:2 128:10 111:6 116:7 119:6 126:9 129:20 forthcoming [4] 68:11,19 153:6
extend [5] 68:12 77:21 167:18 168: favored 127:17
[1]
147:7 159:21 169:8 174:5 198:14 278:3
3 279:6 FDA [32] 2:21 3:7,10,25 6:8,10 8:3, 199:13 200:12 201:16 203:1 213: forums [2] 86:6 87:6
extended [7] 27:11 78:4 130:9,12 8,22 9:10,13 13:2 83:22 84:3 85:6, 20 218:18 237:3 239:4 241:7 256: forward [9] 17:12,13 21:17 50:11
168:11 242:20 308:18 6,12 92:20 95:21 96:16 97:2 172: 9,11,18 257:20 260:15 274:13 101:18 102:6 186:3 229:2 266:12
extending [1] 224:6 15,18 173:5 226:6,8 230:1 250:7 276:5,11 279:22 282:6,10,15 283: found [3] 44:10 84:12 253:18
extension [1] 262:9 283:11 295:9 299:16 309:7 11 297:9 foundation [1] 263:12
extensively [1] 273:11 FDA=s [2] 7:22 8:12 Fish [17] 2:6 5:14,14 7:20 9:21 10: founded [1] 84:13
extent [3] 169:6 206:6 256:19 fear [1] 118:19 2,5 166:12,13 216:6,7,8 258:22 founder [1] 83:17
external 46:7
[1] feasibility [1] 214:7 292:15,16 310:20,21 four [16] 13:11 48:3 64:20 70:13
extra [6] 122:2 269:18,20 270:19 feature [2] 165:15,16 fit [1] 44:2 86:1 89:1 92:14 103:2 137:11 141:
294:7,8 features [2] 122:8 267:4
fits [1] 218:7 22 142:12 149:9 166:4 236:3 282:
extrahepatic [1] 51:2 federal [1] 5:10 five [21] 11:9 27:7 48:4 54:14,17 15 301:22
feedback [2] 4:9 108:6
Sheet 10 except - four
four-week [2] 166:8 227:5 245:14 246:13,18 247:4,5,12,16, 12 45:9 56:11,12,20 67:6 110:10 hammer [1] 97:14
fraction [1] 131:3 20 248:3,3 249:5,6,10,12 250:8 116:1 136:1 138:6 151:12 234:3 hand [12] 7:12 53:12,12 207:9 214:
frame [3] 229:4 242:7,21 251:2,13 252:11,17,21 257:10,12, greatest [10] 66:13 75:2 78:21 113: 4 226:19 227:17 238:19 258:14
framework [1] 38:11 14 304:4 306:19 11,16 179:22 207:4 266:10,11 259:4 263:9,13
frankly [2] 290:5 291:6 genotypes [31] 18:11 19:17 20:1, 274:21 handle [2] 117:15 139:2
free [3] 4:14 153:9 183:16 2,3,16 66:5,11,12,15 69:3 73:17 greatly [3] 185:12,19 301:10 handled [1] 298:17
Freedom [1] 8:6 75:20 109:9,10 111:21 114:3 137: green [3] 55:2 65:13 69:13 hands [1] 201:6
frequency [5] 42:10,10 57:2 194: 21 143:1 148:19 188:1 199:1 202: Greg [3] 150:14 152:14 274:10 hang [1] 176:1
20 307:20 3,4,11 245:6,9 250:14,18 251:11 Greg=s [1] 152:2 happen [9] 100:17 144:14 169:19
frequent [2] 141:16 166:6 257:15 grew [1] 297:8 184:11 254:4 268:17 297:3 300:
frequently [2] 203:12 278:13 gentlemen [1] 174:1 grey [1] 292:12 10 306:19
Friday [1] 313:2 genuine [1] 135:6 groundwork [1] 261:21 happened [2] 36:8 105:1
Fried [1] 40:15 gets [7] 53:12 64:18 94:21 161:9 Group [112] 5:5 21:16 22:21 26:22 happening [3] 32:2 133:20 308:13
front [7] 157:20 196:10 199:10 214: 228:17 234:15 240:18 28:18 37:11 38:2 46:11 47:14 52: happens [4] 34:17 37:14 49:12
10 215:15 245:8 299:1 getting [13] 96:14 220:4 232:3 238: 5 65:2,3,6,9,12 66:1 69:21 72:6 113:11
Frost [1] 49:20 17 246:15 267:1,14 272:22 294:6, 75:2 79:7,12,16 80:6,16 83:7 105: happy [2] 157:6,7
full [11] 86:18 137:19 150:22 180:6 16 296:8 298:21 310:2 10 107:4 111:14 113:15,19 115:3, hard [8] 111:20 126:1 208:20 221:
227:17 256:12 263:3 280:2,3 302: GI [1] 290:1 16,16 125:7 148:13 154:17 155:6 4 223:14 239:8 309:21 310:3
13 305:3 giong [1] 145:16 157:18 172:22 174:4 186:14,18 harder [4] 209:8 249:18 259:22
full-blown [1] 271:12 give [29] 10:1 25:8 33:3 39:6 44:16 188:20 191:17 193:11 195:3,6 294:13
fully [1] 307:15 59:10 75:14 84:11 93:10 107:7 200:10 201:15,16,21 207:10 211: harness [1] 182:22
function [6] 110:21 126:18 127:14 119:7 122:1 124:5 131:6 142:10 11 213:13 214:9 215:12 217:16, Harvard [1] 5:20
128:19,20 204:21 149:16 154:3 157:8,12 165:20 18 221:17,18,21 224:22 227:18 hate [1] 283:5
functional [3] 14:14 18:20 47:5 172:1 195:6 208:21 210:21 216: 234:4 235:5,8,17,20,21,22 238:8,9 Haubrich [25] 2:7 5:11,11 7:19
functions [1] 79:22 14 226:6 268:20 280:16 285:12 239:7 240:6 241:6,7 242:2 243:1 158:9,10 205:9,10 209:2 218:16
fundamental [2] 161:9 162:12 given [18] 26:13 27:22 33:4 41:19 244:7,15 247:12 259:3,11,11,14, 226:4,18,20 238:2,4 245:2,3 256:
fundamentally [2] 145:22 161:20 46:7 47:9 74:7 139:16 149:9 156: 21 262:4,11 263:14 264:18 266:8 7,8 262:17,18 267:13,14 302:5,6
funded [3] 191:6 194:18 234:13 2 158:13,18 261:15 266:18 276:6 269:6 278:10 279:4,6,12,14,16,22 haveB-and [1] 92:8
further [13] 17:1 33:13 40:20 83:6 301:6 307:19 308:3 281:8 284:6,19 285:9 289:17 302: haven=t [8] 37:20 106:1 173:13
114:15 141:11,17 151:22 154:11 gives [1] 36:10 14 303:13 304:11,20 306:11 308: 234:21 240:1 271:20 275:5 283:7
199:15,16 247:5 295:16 giving [4] 92:11 119:14 167:15 17 310:21 311:6 Havens [54] 2:8 5:1,1 156:13,14
futility [2] 40:21 41:4 185:22 group=s [2] 173:3 234:11 163:10 165:20 166:2 207:18,19
future [8] 50:6 154:9 176:7 185:5 glad [2] 83:22 84:3 grouping [1] 235:14 208:15,18,20 221:19,20 223:2,14
190:14 229:17 244:8 257:2 glass [1] 280:2 groups [46] 24:4,16 34:11 36:4 38: 225:12,13 226:18 241:3,4 250:6,7
fuzzy [1] 211:17 gleaned [1] 126:15 8 42:17 71:17 72:5 76:12 112:20 251:3 263:10,11 265:16,17 269:3,
global [1] 11:6 114:10 116:16 122:21 147:5 155: 4,17,22 270:4,7,14 271:2,9 284:14
G globally [1] 10:17 13 194:16 207:6 210:3,10 220:9, 288:3,4,8,15 293:21 294:4,21 295:
Galveston [1] 16:15 Globe [1] 3:29 12 222:7,9 225:4,18,22 227:10 3,20 296:17 297:16 299:5,6 300:
Gary [2] 41:1 49:10 GlobeImmune [2] 180:8,13 234:16 236:10 237:19 238:13 241: 19,20
gate [1] 239:5 goal [12] 100:14 120:5,11 122:21 21 243:12 245:21 246:16 258:15 HBV [5] 112:7,11 115:6 258:18
gathering [2] 172:13 211:20 175:8,11 176:16,18 182:22 274: 264:20 302:1,4,19 303:20 304:1, 282:5
gauge [1] 70:17 12 291:22 295:21 15 305:3 307:17 311:17 HCC [1] 21:10
gave [1] 306:17 goals [6] 50:20 107:6 126:16,21 grow [1] 228:15 HCV [46] 3:16 24:11 25:10,12,13
gemischt [1] 191:17 302:10,17 growing [3] 113:18 138:5 228:15 26:8 27:1 35:5 36:17 40:18 44:19
gender [4] 201:12,13 308:18,19 god [1] 64:4 grows [1] 228:14 50:14 51:9 52:7,9 55:11 58:1,4 59:
genders [1] 188:13 gold [1] 101:13 guaranteed [1] 225:8 22 60:2 72:19 83:11 103:13 112:8
gene [2] 56:8 61:12 Gordon [1] 26:19 guarantees [1] 103:6 116:2 120:20 127:1 128:2 129:14
general [17] 7:12,13,17 8:10,18 16: Gordon=s [1] 28:18 guess [9] 103:1 132:5 150:4 176: 135:4,19 136:12 175:19 178:6
9 44:5 114:8 130:1 140:13 195:9 gosh [1] 123:2 18 202:7,10 237:12 273:14 296: 180:14 182:5 185:3,12 262:3 265:
197:7 205:10 211:13 212:19 244: got [6] 105:10 131:1 152:10 177:22 17 7 268:5 276:16 282:14 286:8 300:
2 273:4 226:14 240:1 guidance [2] 10:3 185:16 16 310:12
generalizable [2] 207:11,14 gotten [1] 155:2 guide [1] 229:17 HCV-infected [2] 60:9 61:12
generalize [2] 218:8 219:13 Gould [1] 3:17 guidelines [1] 23:12 HCV-positive [1] 24:2
generally [5] 38:19 47:3 112:3 government [1] 7:18 gun [2] 67:17,19 HCV-related [1] 48:22
287:5 293:10 grade [4] 67:2,13 69:12 125:5 HCV-specific [1] 185:2
generate [1] 44:15 graft [2] 282:6,10
H HCV/HIV [3] 34:13 262:2 267:5
generated [1] 34:17 grant [1] 223:5 HAART [7] 78:18 81:22 112:9 265: head [3] 28:9 174:4 261:4
generating [3] 36:19 44:11 82:4 granted [1] 309:14 6 266:13,13 277:16 head-to-head [1] 132:15
generation [3] 26:7 50:4 256:17 graph [1] 21:22 HAI [1] 125:5 headed [1] 148:13
genetic [3] 72:14 303:11 311:22 graphic [1] 181:18 half [9] 10:11 27:3,4 74:8 178:6 HEALTH [13] 1:1 5:18,20 48:9 73:
genome [2] 18:16 25:15 gratigied [1] 153:13 280:2,2,3 301:5 4 87:4 144:4 153:15 170:20 189:8
genotype [58] 13:11 20:12,19,19 great [14] 27:6 28:1 82:18 111:10 half-life [9] 58:12 68:4,9 82:3 160: 293:15,16 298:22
25:14 38:21,22 58:20,21 66:9 69: 130:9,17 135:15 139:19 192:7 17 161:5,21 162:2 170:12 health-related [1] 82:13
4,17 72:2 109:15 111:16,17 112: 204:9 222:21 228:8 240:19 307: half-lives [2] 160:19 170:11 healthcare [5] 23:22 24:8 26:3
22 113:10 114:4 118:10 174:16 10 hallway [1] 173:16 194:18 228:20
188:2 199:12 202:8 229:15,16 greater [15] 11:15 19:6 26:14 36: halt [1] 211:10 healthy [3] 273:20,20 293:14
231:17 240:13 244:19,20,21,21,21 HALT-C [4] 147:12,15 167:4,18
Sheet 11 four-week - healthy
hear [5] 22:4 50:7 176:15 289:14 here-Bshow [1] 73:16 243:19 283:5 identifiable [2] 25:21 234:1
302:4 hesitate [1] 242:22 holder [1] 124:4 identification [1] 7:3
heard [12] 52:10 63:16 81:16,17 heterogeneity [3] 117:16 138:21 holders [41] 12:16 14:9,21 15:4 identified [4] 65:16 113:8 225:10
107:17 108:9 112:8 123:17 143: 161:21 106:18 107:1,14 108:7 111:13,19 295:14
20 187:14 226:5 233:20 heterogeneous [4] 115:16 116: 113:6,6 115:13 116:12 118:5,21 identify [5] 187:22 188:2 192:17
Hearing [12] 3:27 15:19 84:3 85:6, 16 138:4,18 119:5 120:14 121:6,7,20 122:3,9 193:14 237:16
10 171:6,15,17 172:14,19 223:6 HGV [1] 62:14 123:2,5,10,11 126:2,15 130:1 135: identifying [2] 246:12 281:11
307:6 Hi [2] 4:20 190:19 7 136:5,10,15 137:16 139:15 140: II [1] 305:18
hearings [1] 95:22 hidden [2] 17:11 135:19 8,22 154:12 194:1 198:10 IIb [1] 232:19
heart [1] 213:22 high [32] 19:5 25:7 29:4 57:2 69: holding [2] 84:3 203:21 III [6] 22:19,22 211:15 215:22 232:
heat [1] 23:16 17 70:15 73:20 76:17 77:1 78:5 holds [1] 71:14 19 305:20
hedged [1] 121:22 91:18 113:10 135:4 151:6 166:7 home [1] 97:14 ill [2] 214:1 231:20
held [7] 6:18 85:6 86:6 118:6 257: 170:2 174:16 177:16 194:4,16 homeless [1] 23:1 illegal [2] 23:14 24:18
1 283:22 308:17 210:12,20 211:1 216:15 232:15 homes [1] 23:2 illustrate [1] 71:3
help [10] 10:7 29:6 38:5 62:22 105: 242:6 267:6,12 289:3 298:11 307: homogeneous [4] 113:13 138:2 illustrated [3] 53:9 57:13 63:12
19 140:9,10 175:20 179:5 216:4 20 312:15 251:1 297:17 illustrates [1] 181:4
helper [1] 56:7 high-level [1] 186:1 honestly [3] 200:15 207:10 306:22 illustrating [1] 73:7
helpful [4] 142:21 146:18 201:5 higher [20] 22:18 45:1,3 69:6,10, Hong [1] 129:5 illustration [1] 181:18
264:17 20 72:5 146:8 177:12 194:22 235: Hoofnagle [2] 25:17 198:12 illustrative [1] 64:21
helping [1] 10:9 8 249:17 279:6 299:11,15,16 301: hope [7] 102:6 106:1 151:21 152: imagine [1] 160:3
hematologic [1] 290:20 8 307:10,10,11 17 153:4 160:1 255:8 imaging-based [1] 47:11
hemodialysis [1] 23:19 highest [2] 75:22 200:13 hopeful [1] 186:4 immediate [3] 14:2 143:12 262:8
hemodynamic [1] 205:1 highlighted [1] 88:13 Hopefully [4] 17:12 82:8 229:5 immediately [5] 35:10 68:10 160:
hemolysis [1] 81:7 highlights [1] 11:5 288:1 8 193:2 294:11
hemophilic [1] 27:10 highly [12] 21:9 28:21 45:20 60:2 horizon [1] 50:19 imminently [1] 200:14
hemotract [1] 68:7 73:3 79:20 185:8 260:1 266:5 273: horse [1] 144:8 immumomodulation [1] 160:6
hence [10] 22:10 52:16 54:3 55:3 2 287:7 293:9 Hospital [3] 16:9 194:20 214:12 Immune [33] 3:29 29:21 52:16,18
56:12,18 57:15 64:2 72:15 300:7 Hilton [1] 1:9 hospitalization [1] 97:18 53:11 55:9 58:13 59:1 60:6,7,12
hep [13] 71:21 91:15 93:9 95:16 hinder [1] 206:7 hospitalizations [1] 98:3 61:6 63:7 68:7 72:12 100:19 136:
104:8 105:12 187:2 200:21 259: Hispanic [1] 311:10 hospitalized [1] 23:2 17 144:3 162:3 180:8 181:15,19,
13 271:21 307:21 310:14,18 Hispanics [6] 114:7 304:9,10,17, host [5] 59:13 75:11 77:4 180:22 20 182:10,14,21,22 184:6 185:1,2,
hepatic [16] 51:1 52:9 61:10 126: 18 306:10 181:14 9 186:1 286:16
18 127:15 184:1,7,15 194:8 195:4, histologic [12] 15:4 47:7,12 54:8 host=s [1] 53:3 immune-based [4] 89:17,22 183:
10,14 196:7 219:5,7,10 113:9,20 125:4,18 129:15 140:2 hostages [1] 312:8 6 186:7
Hepatitis [114] 3:8,11 6:22 9:11,14, 196:5 246:10 Hotel [1] 1:9 immune-mediated [1] 57:5
16 10:12,16,22 12:2,4 14:15 16:2 histological [1] 54:1 hours [4] 32:16 35:18 40:12 42:21 immunoassays [2] 25:5,10
17:9 18:1,1,4 21:19 23:17 24:22 histologies [1] 76:2 House [1] 89:4 immunoblot [1] 25:8
25:19,22 26:1 29:1 49:2 50:20 55: histology [6] 52:20 99:17 125:21 housekeeping [1] 4:5 immunoglobulin [1] 282:20
7 57:14 58:8 59:7 60:21 63:9 73:1 196:8 201:19 292:17 housing [1] 189:9 immunologic [6] 32:8,9 58:8 145:
74:13 85:17 88:21,21 89:2,2,5,6, histopathology [2] 76:1 82:9 However [18] 11:11 37:21 42:18 16 161:16 182:15
16,17,17 91:1,3,18 93:14,17,20 95: historically [4] 20:21 115:4 210: 57:12 80:18 83:3 114:6 121:5 123: immunopathogenesis [1] 55:7
10,14 97:9,17,22 98:2,19 102:21 17 277:7 4 128:9 129:8 138:16 145:18 176: immunopathology [3] 56:11,21
105:7 106:19 109:1,3 110:6,9,15 History [14] 3:11 15:13 16:2,20 24: 13 177:14 262:21 290:16 304:18 60:17
112:10,12,14 115:7 118:7 129:4,6 9,17,18 44:19 74:6 194:10,22 242: huge [5] 196:10 234:12,15 268:13 immunosuppressed [1] 52:15
134:2 152:11 153:12 163:3 174:6, 21 312:11,17 288:22 immunosuppression [3] 39:3
10 180:12,15 181:6 182:12 184:2, hit [3] 4:7 91:7 250:16 HUMAN [5] 1:1 96:7,9,11,17 278:12 281:18
10 186:8,20 187:2,8 188:1 190:6 hits [3] 91:10 92:5 98:7 hurt [1] 77:16 immunosuppressive [4] 56:5
191:5 199:5 215:10 228:22 251:6 HIV [102] 5:15 14:16 23:21 28:20, hypertension [2] 195:13 205:1 277:3 278:17 281:17
260:6 266:9 267:19 271:19 274: 22 36:18,21 46:3 72:19 73:1,4 76: hypertensive [1] 167:8 Impact [24] 3:12 7:13 15:14 16:2,
16 280:10 284:9 286:1,21 287:11 15 78:11,17 82:19 84:12,13,16 85: hypotheses [5] 36:19 38:11 44:11, 20 17:9 53:22 66:13 74:15 76:20
290:6,12 299:8 304:21,22 306:14, 18 87:16,19 88:5,17,20 90:4,22 12,15 79:1 117:19 149:12 151:18 153:8
16,19 311:10 93:3,15,16 94:2,15 95:4,4,7,11,13 hypothesis [2] 58:18 124:17 166:20 169:18 170:21 181:10 184:
hepatocellular [17] 21:10 45:16 97:10,17,19,22 98:11 102:14,17 hypothetical [1] 38:10 7 188:7 224:10,21 229:5
48:6,12 54:16 80:5 82:11 108:16 103:15 105:9 112:7,8,10 115:6 impacted [2] 170:14 173:1
124:21 136:4 154:1 166:19 167: 125:9,11 158:19 187:2,9,11 190:6
I impacts [3] 181:2 278:11 293:14
13 168:7,10,20 217:6 227:13 230:4,9,9 231:21 239:1 i.e [2] 159:12 253:6 impaired [1] 195:14
hepatocyte [10] 27:19,20 43:10,12 240:13,15 241:17 242:11 251:10 I=ll [1] 249:22 imperfect [1] 44:13
57:6 61:5 161:22 162:11 170:19, 258:3,9,18,18 259:2,14,16 260:5, Ib [1] 180:11 implementation [1] 262:8
21 11,18 262:8,10 263:4 265:3,11,19, ICAC [1] 104:17 implies [1] 255:6
hepatocytes [13] 28:3 30:13,17 19,21 266:9,18 267:15,19 268:3,4, ICC [1] 105:8 importance [4] 18:5 102:3 261:2
32:7,11 52:10,13 58:12 59:8 62:8 18 269:8,10 277:1,16 295:7 296:3 iceberg [3] 17:7,10 22:10 281:7
64:1 162:2 170:14 298:10 300:15 306:3 311:8 idea [10] 39:7 136:8 158:14 197:17, important [79] 23:3 42:15 44:9 46:
hepatologists [1] 90:2 HIV-positive [2] 187:11 265:5 20 198:11 210:21 230:12 266:14 3,4 49:8 52:7 55:4,19 56:20 59:4
hepatology [6] 4:21 6:3 16:9 80: HIV/HCV [1] 219:22 282:10 61:19 62:10 64:6,13 65:1 67:7 72:
11 174:3 290:2 hoc [1] 39:16 ideal [3] 113:8 148:11 194:6 20 73:22 78:12 79:19 80:10 81:14,
here-Bof [1] 69:15 hold [6] 96:21 159:12 220:3 221:6 Ideally [4] 133:9 218:10,11 259:10 17 84:5 87:18 90:13 92:7,22 95:2
identical [2] 78:16 106:21
Sheet 12 hear - important
96:15 98:15 108:11 109:4,5 122:8 7 136:5,10,15 137:15,16 139:15 infiltrates [1] 68:5 Institutes [1] 5:18
134:1 138:10,15 145:4 154:22 140:7,22 154:11 194:1 198:10 inflamation [1] 75:4 institutions [3] 7:10,13 194:19
156:11 164:1,19 165:4 167:19 260:13 inflame [1] 68:7 instructions [1] 8:1
170:10 172:16 184:20 193:5 195: Indeed [8] 56:13 58:10 73:5 135: inflamed [2] 63:1 67:1 instructive [2] 61:8 181:15
15 196:3,13 209:7,15 210:13 216: 18 141:3 175:15 247:8 296:9 inflammation [7] 52:19 67:2,6 69: insufficient [1] 269:16
13 221:16 223:15 224:22 230:16 independent [4] 29:2 79:1 105:13, 10 166:18 169:2 170:17 Insurance [1] 234:12
231:19 232:18 235:5 236:13 242: 14 inflammatory [5] 53:19 57:18 68: integrate [1] 158:19
18 243:13 247:12 253:7,8 254:22 indicate [3] 125:8 135:17 227:6 5 170:15 196:6 intended [1] 297:20
266:4 275:20 280:6 281:8 282:19 indicated [4] 108:13 117:9 234:17 inflection [1] 33:14 intent [1] 254:17
284:6 295:12 298:8 268:20 influence [1] 170:18 intention-to-treat [2] 249:17 275:
importantly [6] 52:13,18 80:2 116: indicates [2] 108:11 181:3 inform [4] 70:16 74:19 161:18 164: 7
4 127:22 204:21 indication [13] 11:1,4 74:13 91:12 10 interaction [16] 91:8 133:17,19
impose [1] 281:22 92:3 153:22 182:13 229:1 233:7 information [40] 8:3,6 36:4 42:7 230:5 233:3 260:16 261:1,3,7,13
impossible [2] 193:15 245:13 234:14 269:15,16 271:8 74:17 86:21 142:21 147:13 149: 262:15 264:7 277:2,16 303:5,12
impression [1] 200:10 indications [1] 74:12 19 168:2 169:12 170:9 172:13 interactions [14] 187:21 212:13
improve [6] 97:10 153:14 175:5 individual [19] 19:11 20:11 24:6, 173:2 178:14,21 216:15 220:4,12, 224:18 227:20 259:6,6,18 260:4
184:3,15 196:7 19 30:16 31:10 45:9 46:8 53:7 63: 14 223:16 225:21 228:4 246:19 265:1,20 268:11 277:10 303:4
improved [3] 82:13 99:17 132:17 14,19 64:9 66:19 145:14 156:5 260:12 266:4 269:19 283:19 285: 312:14
improvement [8] 79:19,22 82:9 218:18,22 276:14 286:20 3,18 290:14 293:7,10 294:7,9,15 interactive [1] 4:10
99:16 125:4,6 128:20 129:15 individual=s [1] 172:17 295:11 296:9 300:9 301:13 Interest [12] 3:5 6:12,13,15 7:15 8:
improvements [1] 129:7 individualization [1] 24:14 informative [1] 68:11 9 9:1,4,8 168:6 172:4 191:9
improving [1] 126:17 Individually [1] 9:22 informed [3] 213:17 287:6 293:10 interested [4] 140:8 173:15 176:5
inadequate [3] 275:2 276:7 289:7 individuals [27] 45:22 67:20 69: informing [1] 77:6 196:13
inadvertently [1] 283:10 21 79:3 81:19 116:5 127:3 147:16 inhibit [4] 61:9 63:4 183:14 184:21 interesting [5] 169:16,19 176:15
inapparent [1] 47:10 148:22 149:2,21 151:18 152:15 inhibition [2] 153:7 277:9 178:8 249:8
incapable [1] 80:21 186:11 189:7,8,9 192:17,17 194: inhibitor [5] 91:15,16,20 102:15 Interestingly [1] 127:22
incarcerated [3] 194:17 307:8,12 15 203:22 215:15 224:11 228:22 266:17 interests [2] 7:11 8:17
incentive [1] 93:10 245:16 286:22 307:12 inhibitors [18] 12:8,9 85:4,13 86:5, interfere [2] 62:9,12
incentivize [1] 271:12 INDs [1] 12:7 9 95:16,18 102:7,8,16 103:5,13,15 interferon [89] 11:9,13 13:22 14:
incidence [3] 51:4 82:11 124:19 induced [1] 58:5 145:17 151:17 260:5 266:19 18 29:21 30:21 34:14 36:6,9 38:
incident [1] 108:12 induction [1] 281:18 initial [53] 13:6 16:6 31:17 63:14 17 42:1,2 51:11 58:3,6 59:11,12,
include [25] 24:16 42:7 75:16 114: industrial [1] 7:9 112:5 113:21 114:2 137:15 177:6 21 61:5,21 71:8 72:15 80:22 81:
1 131:21 137:18 154:12 173:2 Industry [15] 2:10 3:23 8:12,15,16, 191:19 197:1,12 200:10 207:15 15 91:22,22 100:12,16,18,20,22
193:6 200:16 202:3 203:10 208:7 17 13:2 15:18 106:7,14,16 170:4 209:22 215:18 225:14,19 226:13 101:4 112:16 115:22 116:10 117:
223:14 224:3 234:3 246:9 253:17 187:15 191:6 256:10 233:13 234:8 235:11 241:4,22 6 118:2,9 122:16 123:20 125:1
268:11,15 271:7 278:18 284:20 ineffective [2] 57:16 276:21 243:9 244:3,17,20 245:1 246:6 131:11,13 135:10 139:16,21 141:
303:19 311:20 ineligible [1] 276:2 247:7,22 253:11 257:13 258:19 1,3,5,6 148:5,8,8,9,10 149:1,4,10
included [11] 88:8 115:21 130:7 inevitable [1] 126:22 259:12,13 263:16 264:10 265:10 151:7 159:9 163:8 175:6,14 176:8,
189:10 203:12 215:19 217:10 225: inexorably [1] 81:12 268:8 269:2 270:22 284:13 285: 13,17 179:17 191:13 192:2 193:7,
17 232:13 302:22 307:8 infect [1] 82:5 17,19 294:9,14 296:20 297:2,3,16 8 196:1 231:3 247:9 254:1,4,10
includes [4] 88:10,11,11 263:20 infected [38] 11:2 21:19 22:9 23:8 311:7 255:8,13,16 256:1,11,21 287:16
including [12] 23:1 35:17 62:14 27:21 28:4 30:9,11,13 32:1,7 36: initially [7] 13:16 33:13 111:11,15 289:6 290:15 291:1,10 292:9
89:5 110:15 216:9 224:11 257:17 17 43:16 46:11 53:15 56:13 57:6, 222:14 223:12 264:21 interferon-alpha [6] 59:4,9 60:5,
258:3 284:7 302:8 308:2 8,18 58:9 63:13 64:1 73:1 81:19 initiate [4] 215:14 228:6 232:20 10,22 61:9
inclusion [18] 72:17 76:11 77:9,11 82:3 108:14 112:2 161:22 162:16 268:9 interferon-based [31] 21:4 29:4
78:3 137:15 138:6,18 188:13,22 170:13 181:18 182:9 184:7 187:1 initiated [6] 174:5 177:18 232:22 37:3 63:10 72:13 109:8 113:1 114:
189:2 196:22 197:11 241:22 249: 199:4 228:22 272:16 287:2 254:17 259:12 270:10 16 117:17 122:11,12 123:22 131:
5,6 279:13 281:14 Infection [59] 3:16 10:20,22 18:4 initiation [6] 179:14 228:3 243:5 5 134:18 135:16 139:13 141:10
inclusive [4] 75:17 76:6,11 203:16 22:11,12 23:13 25:22 26:4,9,14, 262:2 301:18 305:15 150:7 156:18 158:14 159:8,15
incompatible [1] 224:16 15 27:5,20 28:17,20 32:4 38:3 39: injectable [2] 253:17 254:10 161:2 162:19,19 179:8 183:10
incomplete [1] 72:10 3 43:16,20 44:3,20 45:4 48:16 50: injected [1] 23:14 192:1 195:21 196:9 221:2
incorporated [1] 134:13 14,20 51:9 52:8 53:14 55:8 59:7 injection [1] 99:1 interferon-containing [1] 115:21
incorrectly [1] 224:1 62:11 66:9 72:2 74:4,7 78:18 80:9 innate [3] 60:7,11 72:12 interferon-free [1] 124:12
increase [8] 27:11 48:18 61:16 72: 83:11 99:2 108:12 109:1 180:12, input [7] 10:7 118:3 121:14 129:12 interferon-gamma [2] 60:15 62:
4 211:9 231:16 248:21 303:9 16 181:17,21 182:2,6,17 187:9,12 133:4 185:13 197:3 21
increased [5] 10:15 23:13 48:11 231:10 279:11 286:13,16,19 287: inquired [2] 12:18 13:20 interferon-regulated [1] 59:14
65:17 74:3 1 290:6 insert [1] 294:9 interferon-resistant [1] 193:10
increasing [5] 60:16,18 108:17 infections [11] 5:6 6:22 10:17 21: insights [1] 154:10 interferon-ribavirin [10] 91:21
150:16 236:4 7,8 22:4 51:1 58:20,21 75:21 183: insisted [1] 89:20 130:3 151:8 208:1 233:11,14 234:
increasingly [2] 187:10 276:2 2 insistent [1] 131:20 4 235:3 287:20 290:13
increment [1] 71:12 infectious [5] 5:2,12,14 16:14 231: insofar [1] 159:9 interferon-treated [1] 61:12
IND [44] 12:16 14:9,20 15:4 106:17 10 instance [4] 120:6 253:6 289:17 interferon=s [2] 62:4 139:20
107:1,13 108:7 111:13,19 113:5,6 infectivity [1] 28:5 307:7 interferons [4] 12:9 73:15 112:13
115:13 116:12 118:5,21 119:4 infects [3] 44:4 52:9,13 instances [3] 120:12 140:4 231: 127:12
120:14 121:5,7,20 122:3,9 123:1, infer [1] 162:15 11 interim [1] 167:7
5,10,11 124:4 126:2,15 130:1 135: inference [1] 154:4 Instead [3] 29:3 97:11 166:21 intermediate [1] 262:19

Sheet 13 important - intermediate
intermittently [2] 53:21 137:9 299:1,2,7 301:1,22 303:4,5 308: killer [2] 60:7 181:20 lateral [2] 56:16,18
internal [2] 18:18 98:1 11 309:1,3 310:16,19 kilo [2] 299:9,10 latest [1] 86:19
international [1] 247:17 issued [1] 23:12 kind [13] 34:12 43:1 150:2 151:1 Latinos [3] 75:18 98:11,16
internet [2] 86:11,16 Issues [66] 3:9 4:5 6:21 7:2,6,7 9: 166:13 175:3 195:19 207:20 230: latter [1] 51:22
interpose [1] 70:17 12,14 10:9,11 11:17,19 12:15,17, 20 235:22 241:5,6 277:11 laudatory [1] 276:20
interpretability [1] 134:15 21 17:13 42:18 49:11 50:9 54:6 kinds [5] 164:13 179:19,19 185:18 Laughter [8] 146:17 198:19 238:1
interpretable [2] 138:3 139:3 61:20 70:8 74:18 79:11 80:17 84: 218:14 272:8 295:5,10 299:21 305:8
interpretation [3] 107:21 155:14, 7 87:12 90:1,2 96:8 98:14 109:12 kinetic [13] 31:18 32:22 35:10,14 launch [1] 272:4
16 118:3 125:21 143:16 145:8 146: 39:18,21 40:7 41:9 42:17 59:16 launched [2] 89:1 197:17
interrupt [1] 202:12 12 156:11 158:12 181:5 186:1,7 159:20 243:3 285:1 law [1] 171:19
intervals [1] 193:2 188:5,7,9 189:7,8,17 190:11 193: Kinetics [21] 3:12 15:14 16:3,22 layers [1] 171:2
intervenes [1] 29:19 7 195:18 202:18 212:13,21 217:1 28:10 35:7 58:1 134:22 164:8,11 lead [11] 47:20 161:5 185:10,17
intervenesB-interferon [1] 29: 225:10 233:3 234:21 235:1 252:4 169:9 181:13 183:5 184:13 222:2 186:5 224:17 233:7 270:20 288:
20 258:9 274:1 298:4 309:1,7 311:22 223:16 228:5 265:1,18 282:14 17 295:17 309:9
intervention [2] 38:7 55:22 itB-do [1] 254:7 288:10 lead-in [1] 240:18
interventional [1] 67:16 itself [7] 27:21 29:1 57:14 122:6 king [1] 120:17 leading [12] 21:12 52:19 55:11 57:
intolerability [1] 11:19 132:12 255:15 275:12 Knodell [1] 125:5 16 81:7 86:10 97:18,22 98:3 99:2
intolerance [3] 125:1 174:21 175: IUs [2] 123:8,11 knot [1] 56:2 114:11 152:14
3 IUs/ml [2] 69:6 120:21 knowing [2] 54:3 78:7 leads [13] 19:9,16 31:1,13,22 33:
intranasal [1] 24:17 IV [3] 230:11 232:20 270:13 knowledge [4] 83:9 137:19 158: 14 37:15 44:5 49:14 57:9 70:15
introduce [3] 16:1,7 27:14 15 275:3 72:6 81:10
introduced [1] 153:10
J knowledgeable [1] 62:2 leap [1] 242:12
introduces [1] 38:9 Jak [1] 59:12 known [4] 77:14 170:19 178:13 learn [5] 37:9 104:10 222:20 241:
introducing 206:8 [1] Jan [2] 220:7,10 245:8 19 256:20
introduction [6] 4:17 107:18,19 Janet [5] 2:5 5:19 7:19 272:15 302: knows [2] 109:8 120:8 learned [3] 51:10 190:5 211:8
108:9 156:17 180:5 7 Kong [1] 129:5 learning [1] 109:3
introductions 16:6 [1] Janice [3] 3:28 173:19 174:1
least [47] 16:21 21:6,7 40:8,10 54:
Introductory [3] 3:7 9:11,13 Japan [1] 168:14 L 1 66:2 71:7 94:18 114:10 115:17
Intron-A [1] 174:5 Jay [1] 198:12 L-aminotransferase [1] 53:17
116:9 127:18,20 128:2 132:9 136:
intrude [1] 117:6 Jeff [1] 151:5 label [2] 138:9 294:10 13 145:20 206:2,6 216:12 222:5,
intuition [1] 136:18 Joe [1] 25:17 labeling [1] 271:7 11 226:22 227:3,18 232:6 242:19
inverted 308:10
[1] John [16] 2:20 3:16 6:2 7:20 15:15 Laboratories [2] 6:1 8:19
245:11 261:14 262:20 268:9,18
investigational [15] 14:11,19,22 50:7 71:3 151:12 196:6 210:4 220: lack [6] 79:15 108:20 124:22 125: 269:15 291:1,14 292:1 293:2 297:
94:5,11 97:5 129:21 130:16 131:2, 17 273:15,21 281:13,15,21 20 192:7 264:6 5,20 301:18 303:19 304:13,19
15 133:6,21 179:15 214:17 247:2 joining [1] 180:12 lacking [1] 189:9
307:21 308:1 310:17
investigator [1] 114:13 journal [2] 86:18 153:20 lacks [1] 19:8 leave [2] 49:19 64:14
Investigators [1] 178:20 judiciously [1] 107:12 ladies [1] 173:22 leaving [1] 77:15
invited 8:12 85:8
[2] Jules [5] 3:20 15:16 83:16,17 230: Laessig [3] 2:23 6:7,7 led [1] 70:2
inviting [1] 83:21 9 lag [2] 26:5 212:13 leeway [2] 210:15,22
involve [4] 7:9 8:20 161:20 203:1 July [1] 23:19 laid [1] 261:21 left [8] 30:8 31:21 44:3 54:13 56:7
involved [14] 18:21 34:10 35:20 jump [3] 171:8 238:2 289:2 language [5] 84:21 89:5,7,8,10 62:20 83:8 110:5
94:18 147:11 151:2 177:1 201:9, jumping [1] 102:14 languishing [2] 89:4 96:20 legitimate [1] 274:9
10 220:20 289:16 291:20 292:8 jumps [1] 17:19 large [22] 27:9 46:11 66:7 67:11,12, length [2] 21:2 166:15
293:3 jury [1] 299:19 14 76:7 94:1 135:22 178:17 191: Leonard [4] 2:18 5:17 202:12 223:
involvement [2] 9:1,5 justB-I [1] 214:14 17 195:21 220:16 221:21 222:9 22
involves 31:14[1] justification [1] 154:18 265:5 266:8 274:18 287:21 291: less [34] 29:5 37:7 38:2 39:1 44:2
15 300:5 305:5
involving [2] 56:15 71:17 K large-scale [1] 228:3
62:1 65:16 68:14 117:22 120:9,9,
ionosine [1] 62:9 Karen [6] 2:15 3:31 4:19,20 7:19 20 123:16 129:3 136:3 146:7 150:
Ireland [1] 46:10 largely [6] 20:4 32:4 57:6 74:15 18 151:17 165:12 170:14 172:6
190:17 148:19 153:18
IRES [1] 18:19 Katherine [1] 2:23 174:21 187:13 190:1 203:12 212:
ironed [1] 94:3 larger [6] 67:19 96:11 146:21 177:
6 214:1 219:1,2,6 244:8 286:13
Katie [1] 6:7 16 225:11 259:12
Ischak 125:6
[1]
keep [11] 17:7 28:8 47:16 59:20 95: largest [5] 69:19 144:13 229:1 230: 298:14 310:16
isn=t [4] 136:21 160:11 234:11 20 102:19 126:2 170:10 193:10
lesser [4] 194:7 218:1 286:2 292:
302:13 8 264:16 21
199:3 246:2 Larry [1] 66:7
isolated [2] 19:14 20:21 keeping [1] 77:12 lesson [1] 190:8
issue [75] 6:15 28:9 37:5 49:8 64: Ken [7] 15:12 16:1 84:6 159:20 last [9] 22:16 81:10 88:14 139:16 lessons [1] 51:9
10 66:17 71:4 76:22 79:9 112:12 141:9 189:2 211:5 269:5 301:20 Let=s [13] 4:18 63:9 91:16 95:13
162:6 191:2 240:2 Lastly [11] 111:2 112:18 115:8 116:
121:15 143:12,18 144:7 145:6 102:19 106:4,6 136:12 209:3 253:
Kenneth [4] 2:2 3:3,13 7:20 3 120:13 124:8 125:8,16 131:4
150:2,7,12 156:11 161:10 162:1 16 254:2,4 258:17
Kessler [1] 85:14 133:6 135:2
164:2 167:10,13 173:9 192:9 193:
key [5] 25:15 54:5 94:4 280:15 284: late [1] 162:15 lethal [1] 127:14
17,21,22 197:8,14 199:7,12,17
16
level [8] 27:8 33:11,13 95:10 165:
201:11 214:4,6 223:7 226:9 241: latency [1] 108:19 10 251:5 277:15,22
kibosh [1] 210:18 later [23] 25:3 38:3 50:1 57:2 71:
19 244:5,10 245:21 246:12 249:9
kid [1] 298:17 levels [14] 19:5 33:17 42:8 58:4 61:
251:13,17 258:2,11 267:8 271:19 13 120:3 121:9 139:17 144:12 16 127:5 140:6 165:8 260:6,7 277:
kids [6] 294:17 296:4 298:14 299:7, 155:6 157:7,19 163:20 164:11
272:9 273:14,16 274:2,5,13,14 8,13 278:12,13
20 301:15 187:16 208:10,18 212:9 234:22
275:14,20 276:10 284:17 298:15
kill [1] 197:21 Levin [5] 3:20 15:16 83:16,21 230:
241:18 242:1 299:5 311:21
Sheet 14 intermittently - Levin
9 293:5,13 296:3 298:20 lots [1] 104:11 marginalized [2] 98:22 99:1
Liauw [1] 153:19 liver-related [1] 48:13 loved [1] 121:2 mark [1] 40:16
licensed [2] 178:4 207:6 livers [1] 61:11 low [18] 23:7 24:7,12 69:5 135:5 marker [2] 29:2 53:19
licensing [1] 262:7 lives [2] 261:7,11 149:22 150:15 204:12 238:9,18 markers [2] 61:15 181:14
lie [1] 187:6 living [5] 84:14 145:3 152:8 260: 271:22 275:8 278:22 280:4 282: market [18] 11:10 90:13,15 91:7,
life [7] 54:22 55:3 82:13 250:4 252: 18 293:16 11,12,13 309:4 10 92:5 93:6 94:17 98:7 100:2
4 276:7 293:18 load [30] 27:1,2,11 28:21 29:1 30:5, lower [21] 14:17 33:13 63:12 72:7 103:6 105:19 155:3 199:20 200:8
life-saving [1] 213:21 10 31:18 33:5,10,20 37:6 41:19 104:18 112:22 123:9 131:11,14 207:3 242:7 299:4
life-threatening [1] 261:2 43:14 63:13 69:4,18 113:10 127:4 146:8 169:20 194:16 195:11 255: marketB-I [1] 207:2
lifestyles [1] 189:5 135:22 140:11 162:11 163:16 165: 6 266:3 275:16 300:17,18 301:11 marketing [8] 13:8,14 215:18,19,
lifetime [1] 93:17 14 166:22 169:21 183:10,22 184: 302:20 303:6 22 248:15 264:10 285:17
light [1] 100:19 13 267:12 lowering [1] 300:13 marrow [2] 127:13 150:12
likelihood [8] 49:12 149:15,22 loads [6] 28:13,15 29:5 69:6 267:6 lowest [1] 111:17 marvelous [1] 231:6
152:18,20 195:11 238:15 262:5 282:13 LSU [1] 5:7 Maryland [2] 1:10,11
likely [32] 11:5 29:5 39:1,7 65:16 lobule [1] 47:4 lucky [1] 280:10 mass [1] 161:22
108:22 117:20,22 125:2 134:5 localized [1] 60:15 lunch [3] 142:6 171:10,12 Massachusetts [1] 16:9
136:2 141:1 143:12 165:10,12 lodging [1] 173:4 lymphocyte [1] 55:12 master [2] 19:15 25:15
170:1 173:1 184:6 185:8 192:2 log [7] 27:3,5 37:8 116:2 129:14 lymphocytes [3] 18:13 52:10 55: matched [2] 35:5 36:9
219:11 220:5 221:22 227:7 231: 236:3 238:19 20 maternal [1] 112:3
20 235:8 249:21 257:19 262:9 logical [1] 212:3 math [3] 29:11 31:1 286:5
268:17 286:15 306:20 long [25] 12:22 33:18 37:19 41:12
M mathematical [4] 19:21 29:9 31:
Likewise [1] 173:5 63:21 64:11 68:9 77:21 80:3 96: M.D [21] 2:2,6,7,8,10,12,15,16,18, 14 41:17
limit [2] 63:12 292:8 20 103:17 106:1 108:19 142:7,10 20,22,23,24 3:3,9,13,16,24,28,29, mathematics [1] 35:19
limited [10] 11:18 23:4 72:2 101: 144:21 163:1,12 214:20 228:12 31 matter [4] 151:10 161:3 186:2 252:
15,16,16 135:2 141:4 206:14 210: 239:3 246:22 264:3 288:4 293:15 made
[22] 6:16 24:20 48:10 53:4
6
5 long-term [23] 7:4 24:10 49:16 61: 90:20 95:11,12 98:2 102:14 155:7, matters [1] 7:17
limiting 172:5
[1] 20 80:6,7 82:12 104:7,9 105:6 13 156:2 157:15 184:20 192:16 maximum [2] 172:5 299:17
Lindsay [4] 3:31 190:17,19 204:21 135:14 137:1,7 141:19 149:8,12 214:19 218:7 224:1 239:19 268:9 maxing [1] 217:2
line [4] 34:19 101:7 110:12 211:15 162:14 163:3 167:10 169:4 175: 288:15 292:20 McHutchinson [1] 71:4
lipids [6] 104:17,19,22 105:1,2,3 16 184:5 244:7 magnitude [1] 182:4 mean [32] 33:3 91:13 104:4,5 112:
longer [16] 20:12 28:6 45:8 68:15 main 25:1 29:3 39:9 90:18,21
[7]
liquid [1] 291:5 7 117:13 128:8 165:17 177:17
Lisa 74:10
[1] 73:17 82:4 119:2,10,16 133:15 108:2 302:22 200:21 213:19 221:11 223:7 231:
list [16] 75:7 76:15 79:4 142:7 153: 136:19 141:15 157:16 192:20 217: mainly 194:12
[1]
13 236:17 245:17 247:11,13 251:
13,16 199:22 205:8 210:3 216:20 13 249:22 maintain [2] 260:5 282:16
19 282:12 283:15,20 294:10 297:
217:12 228:14,14,17 276:4 312:9 look [54] 17:15 27:4 33:2 36:4,8,16 maintains [1] 260:7
14 298:13 303:17 304:2,11 308:8
39:22 46:21 50:18 51:10,16 54:19 maintenance 167:4 281:18
[2]
listed [5] 78:21 204:2 217:1 218:1 309:16,18 312:7
274:3 59:16 64:6,20 66:17 69:5 73:13 major [16] 67:10 75:1 76:12 87:3,4
meaning [5] 30:13 44:3 197:8 227:
listened [1] 264:13 74:10 79:5,11 90:3 93:15,19,22 88:19 119:1 135:4 241:7,9 245:11 11 302:10
listening [1] 106:2 111:21 143:22 145:7,20 148:18 268:11 303:19,22 307:16 309:3 meaningful [4] 140:6,10 163:21
listing [1] 210:8 149:18 157:19 168:2 174:20 181: majority [5] 107:6 194:9 298:19
238:21
literally 297:13
[1] 15 182:13 233:1,2,17 236:20,20 304:16 311:10 means [8] 77:7 122:13 155:10 211:
literature [9] 40:4 58:8 126:14,16 240:11 241:10 243:3 260:3 277: make?@ [1] 37:8 18 214:16 227:13 307:9 308:14
129:5,16 135:16 164:21 165:18 20 280:3 304:2 305:18 307:22 makeB-because [1] 90:19 meant [1] 17:2
little [37] 22:17 28:12 35:22 38:21 309:7 311:8 312:9,13 malignant [1] 51:5 measure [4] 53:18 79:20 164:3,7
47:2,3 84:11 98:9,20 100:4 101:2 looked [4] 27:1 149:2 254:19 286: managed 168:3
[1]
measured [2] 121:16 156:21
131:14,14 156:10 158:18 163:11 10 management [3] 23:22 163:6 203:
measurement [3] 25:13 35:18
169:3 178:14 207:20 208:2 210: looking [30] 22:21 33:16 39:17 45: 19 121:18
15,22 211:17 216:4 218:8 219:12 21 46:10 49:11 59:5 79:2 102:5 mandate [2] 243:16 293:2 measurements [1] 183:11
242:11 243:6 245:4 262:18 277: 113:3 115:17 137:8 143:7 146:3 mandated [2] 273:5 284:12 measuring [3] 27:2 147:3 253:15
151:15 152:6,21 168:8 171:3 184: mandating 299:1
[1]
21 294:7,8 300:18 301:21 307:9, mechanism [5] 32:6 132:6 181:11
11 8 193:6 205:18 211:16 213:5 238: manifest [1] 45:13
183:13 185:9
liver [93] 5:17 6:3 11:1 13:13 17:16, 4,12 246:18 264:22 273:3 275:16 manifestations 51:2 80:1
[2]
mechanisms [11] 27:17 32:9 51:
21 18:2,12 21:12 22:6 23:20 25: looks [8] 53:18 57:22 61:20 73:6 manipulating [1] 131:13
11 57:22 59:3,19 62:3 72:10 133:
20 26:11,12 28:1 45:10,13,15 46: 91:17 227:18 271:17 280:1 manner [4] 18:3 81:6 205:21 282: 10,22 192:8
22 47:4,5,18,20 48:3 54:5 55:15 Los [1] 86:7 4 median [1] 26:6
61:17 62:20 66:17 68:7,8 71:15 lose [1] 175:22 manufacturers [2] 85:8 254:3 mediated [3] 52:16,22 60:18
73:8 75:2 101:14 105:3 108:16 losing [1] 199:3 many [47] 7:9,13 20:1 22:12 44:9, Medical [17] 3:19,24 5:2,7,15 6:5
109:4 110:9,13,19 111:22 113:22 loss [5] 25:7 30:16 42:8 175:15 14 46:1 61:13 67:15 73:7 75:15 10:2 16:15 24:8 49:5 86:21 179:
119:19 120:2 124:20 126:3,6 127: 237:13 76:13 77:3,10,13 88:16 89:16,16 22 180:7 198:4 217:17 219:4 300:
4,6,10,14 128:16,19,20 134:16 lot [31] 29:11 39:15 84:7 90:19 93: 90:2,2 99:1 105:5 111:8 143:14 8
136:3 137:17 143:11 144:5 152:9, 11,12 94:9 95:11 98:17 104:10 150:19,21 152:10 172:8 179:1 medication [1] 292:13
16,19 160:20 187:9 195:5,5,13 131:19 178:1 192:20 196:7 213: 189:5 197:4 210:2 215:7 219:13 medications [3] 290:18 291:1
199:16 203:2 212:6 213:15 215:8 20 218:9 226:9 227:14 238:5 240: 234:1 242:19 247:2 251:2 261:5 312:14
219:20 221:11 222:20 223:8,9 14,22 263:11 266:18 267:16 278: 274:22 276:3 289:19 295:2,7,7 Medicine [5] 3:17 5:15 6:3 98:1
228:4,6 230:7 231:14 232:1 273:6, 14 289:22 298:12 309:14,15 310: 299:15 306:2 192:12
20 276:7 284:18 285:10 286:14 2,3 March [3] 86:4 106:17 126:5
medicines [2] 189:20,22
marches [2] 120:8 135:18
Sheet 15 Levin - medicines
meet [5] 103:8 111:4 175:13 215:7 223:22 224:20 232:1 246:2 290:8 272:20 multi-drug [1] 134:7
291:22 309:13 mono-infection [15] 87:14,16,21, multi-investigational [2] 96:13
meeting [18] 4:3,12 6:17,18 7:9,21 minds [1] 136:14 22 88:10 91:13 99:21,22 100:7 105:18
8:3,14 12:13,15 15:11,12 17:12 mine [1] 116:17 187:19 261:22 262:4,13 271:15 multi-phase [1] 164:18
50:5 172:15 173:1,5 312:3 minimal [5] 147:21 166:14,15 231: 310:12 multi-specificity [1] 59:21
meets [1] 6:20 18 290:20 mono-specific [1] 60:3 multiple [16] 18:11 19:12 24:10,22
MEL [1] 151:12 minimally [1] 151:11 monophosphate [2] 62:8,10 34:15 94:5,11 97:4 100:14 121:13
MELD [15] 79:20 128:17 129:8 140: minimize [4] 46:15 134:20 276:18, monotherapy [28] 14:14 15:1 58: 179:15 214:21 246:20 257:15 275:
7,11 145:21 146:7,8 204:9,11 225: 20 3 61:13 64:10 80:22 103:11,16 17 276:15
6 278:22 279:2,6 280:4 minimizing [1] 298:20 118:19 119:12,16 130:9,13 132: multispecific [1] 55:14
member [3] 7:15 62:15 186:18 minimum [4] 168:15,16 177:7 261: 21 135:3,10 140:17 141:4,7 148:8, Munk [5] 2:9 16:11,11 229:21 268:
MEMBERS [10] 2:4 4:6,18 7:10 9: 12 9 163:12,15 190:3 209:6 236:2 2
17 16:5 114:8 142:11 197:4 288:2 minor [2] 33:7 34:4 240:21 282:21 Murray [18] 2:15 4:19,20,20 7:19
membership [1] 105:16 Minorities [1] 137:18 monotherapyB-agreement [1] 154:8 272:6 285:12,15 289:12
men [4] 38:18 188:14 201:14 308: minority [1] 201:3 135:2 291:14,20 292:7,16,19 294:18
20 minus [2] 29:14 31:6 month [2] 71:14 166:10 295:1 299:18
mental [2] 189:8 293:16 minutes [5] 92:18 172:1,5 186:12 months [6] 26:15 37:11 110:10 must [6] 58:22 188:8,16,18,19 209:
mention [8] 84:8 88:14 95:15 100: 203:8 119:3 175:18 252:20 21
4 101:12 188:10 293:18 312:10 Miriam [9] 2:14 16:13 49:21 146: moot [1] 231:12 mutagenic [1] 62:15
mentioned [21] 21:6,11 72:19 88: 13 147:10 216:19 223:7 306:8,14 more.@ [1] 136:7 mutation [1] 235:1
1 98:17 99:12 100:6 103:2 115:5 mirrored [1] 48:18 morning [22] 9:15 10:10 29:11 mutational [2] 179:20 235:7
135:11 145:6,19 160:11 174:11 Miss [2] 259:5 290:18 106:9,10 111:9 142:3,12 174:9,12 mutations [1] 170:1
178:10 181:22 191:2 195:19 210: missing [2] 43:3 290:19 175:7 177:14 178:2,7 190:4,20 mutually [3] 56:6,9,14
4 280:18 312:12 mistake [3] 102:13 126:4 223:3 191:16 193:22 198:9 233:21 237: mycophenolic [1] 277:20
messes [1] 35:19 mistakes [4] 95:11,13,14 102:4 22 312:22 myself [4] 52:2 84:12 126:2 286:6
met [2] 87:3 150:17 misunderstand [1] 294:3 mortality [7] 48:13,17,18,22 74:3 mysterious [1] 117:12
metabolic [2] 51:4 188:11 misunderstanding [1] 157:3 79:21 151:6
metabolics [1] 104:12 misunderstood [1] 205:6 most [59] 10:22 20:18,20 21:18 22:
N
metabolism [6] 133:18 219:5,10 mitigated [1] 8:11 19 27:1 30:19 31:21 43:15 47:9 naive [36] 13:7 14:4 56:1 118:6
233:1,4 277:10 mix [1] 281:19 64:22 70:14 71:21 75:20 76:19 77: 139:7,8 140:16 143:8 201:21 202:
metabolized [2] 170:19 227:15 mixed [3] 185:15,18 304:10 19 78:12 90:9 98:21 99:5 109:3 1 206:9 210:18 211:9,10 217:21
metallo-matrix [1] 61:18 mobilizing [1] 185:1 113:13 118:8 120:19 125:2 134:5 233:11,13,22 234:7 235:9 237:5
methadone [1] 99:4 modality [2] 185:15,18 138:2,3 143:12,13 146:12 154:16 238:5 240:7 244:2 246:17 259:13,
method [1] 29:20 model [18] 34:20 35:2,13,16 36:1 166:11 175:10 189:13 192:11 204: 16 262:2,3 263:15 264:5 272:12
methods [1] 25:11 42:11 43:4 49:14 90:4,22 94:12 21 205:17,17,20 207:4 210:1 211: 275:11 280:19 283:6 285:9
Mexican [2] 304:11,19 95:3 125:11 128:16 165:2,6 242: 22 216:10 219:13 222:7 232:17 naive-treated [1] 143:1
mg [3] 255:22 301:3,5 11 290:3 235:21 272:1,3 283:7 286:15 292: naivete [1] 283:4
mid [1] 174:7 Modeling [17] 19:5 29:6 31:14 32: 10,21 293:4 297:17 298:15 304: name [4] 173:13 174:1 180:6 186:
middle [7] 59:10 158:21 212:16 22 36:3 37:9 38:6 39:21 41:9,16, 22 306:19 16
304:3,3 309:10,22 17 42:4,17 81:21 161:18 166:1 mostly [2] 126:13 310:12 Namely [2] 12:18 149:3
might [62] 20:10 37:7 58:16 85:22 170:8 mother [2] 109:2 287:2 narrow [4] 182:11 247:4 296:21
100:16 101:1 103:8 107:3,8 114: models [21] 34:17 35:20 39:19 42: mothers [1] 24:2 297:1
22 119:11,17,21 128:14 130:13 7,12 43:6 44:1,8,13 59:8 60:17 motivated [2] 287:7 293:9 NATAP [6] 3:22 83:18 84:13 86:5,
132:16 133:17,19 134:17,19,19 160:22 164:14,18,20,22 166:5 move [19] 17:13 50:10 90:1 96:2,3, 10,12
142:21 143:5 144:14 153:6,22 184:8,10 275:10 290:13 10 99:7 100:14 101:18 105:15 National [4] 3:22 5:18 74:10 83:18
154:4 162:6 163:17 166:19 169: modifiable [2] 43:18 46:8 108:4 122:12 163:21 176:20 200: Natural [13] 3:11 15:13 16:2,19 44:
18 178:12 181:2 185:14 192:21 modification [1] 278:16 9 209:4 264:8 266:11 305:20 19 58:11 60:6 74:6 82:3 194:10,
204:11 206:10 208:2,5 209:5 212: modified [1] 255:19 moved [1] 80:15 22 204:5 242:21
17 214:13 221:11 222:7 229:13, modifier [3] 46:3,4,5 moving [12] 21:17 81:11 110:12 naturally [1] 181:16
15,17 238:7,20 241:5 242:15 243: modifiers [1] 46:2 118:5 122:19 126:1 131:10 137: nature [9] 8:10 22:18 87:19,20 99:
6 249:13 266:16 267:10 269:12 modulators [1] 29:21 14 146:7 176:21 199:15 229:2 19 154:15 257:11 274:15,16
279:17 284:9,11 290:10,10 295: molecule [4] 29:22 221:3 241:13 mRNA [1] 61:10 NDA [1] 180:15
17 242:3 MS [11] 5:4 197:16 211:13 212:2 near [4] 163:5 176:7 218:4 225:9
Mike [1] 40:15 molecules [4] 12:8 160:18 240:3 234:10 240:10 260:15 266:7 271: near-term [1] 185:10
mikes [1] 4:7 247:9 11 305:17 312:7 nearly [1] 72:7
milder [1] 112:3 moment [4] 112:19 147:1 191:7 much [58] 10:3,7 15:22 17:10 31: neat [1] 234:1
mildly [1] 127:19 271:16 15 32:12 36:11 37:8 38:3 41:19 necessarily [17] 58:13 59:22 92:3
miles@ [1] 83:8 momentB-and [1] 221:10 45:3 50:15 58:7 67:18 83:14 86: 105:13,14 206:12 211:10 233:6
milieu [3] 56:3 63:5 170:15 moments [1] 112:8 15 88:18 103:20 105:22 118:16 236:17 256:18 257:14 260:9 284:
military [1] 23:1 money [1] 214:7 126:3,14 127:9 142:4 160:12 177: 12 291:9 293:8 300:21 303:9
million [10] 10:19 11:2 21:7,8 22:8, moninfection [1] 88:3 1 180:1 194:21,21 198:2 201:9 necessary [6] 62:11 141:11 165:
13 23:8,8 108:10,10 monitor [2] 179:10 278:13 202:5 209:6 235:8 237:11 242:12 14 230:2 304:12 311:21
Milwaukee [1] 5:3 monitored [1] 141:21 252:2,4 258:9 264:7 271:3,20 275: necessity [2] 41:14 260:8
mind [20] 17:8 47:17 59:20 74:17 monitoring [3] 211:9 277:8 308: 19 277:19 279:2 281:1 285:18 necroinflammatory [1] 203:16
82:15 94:10 95:20 102:20 143:16 14 289:13 290:16,22 298:18 299:15 need [137] 4:7 11:3 13:14 23:22 24:
170:10 182:22 206:4,18 214:6 mono-infected [3] 35:5 91:19 301:5,8 304:13 311:15,17 312:21 5 44:12 47:16 50:10 67:14 68:2
72:15 81:15 88:6 90:3,16,22 91:2
Sheet 16 meet - need
93:10 95:20,22 96:2,6,9,18 98:5 NIDDK [5] 5:18 71:21 147:11 152: 21 181:10 239:6 255:14 282:3 olds [2] 298:1,2
99:6,8 100:1,18,21 101:2,17 102: 7 198:13 nucleocide [1] 151:16 oligonucleotides [1] 12:11
8,20 104:7,8,9 105:5,12 111:10 NIH [7] 105:14 191:6 198:10,16,16 nucleocide/nucleotide [1] 153: OLT [1] 80:9
113:17,21 114:12 122:13 124:4 202:1 220:19 11 on-Band [1] 176:14
126:19 133:12 136:7 138:6,9 141: NIH/Roche [3] 291:17,21 292:7 nucleotide [1] 18:17 onB-is [1] 176:16
15 142:13 146:9 156:12 157:18 Nile [1] 20:19 null [6] 116:20 238:13 239:6,20 once [14] 27:5 48:1,6 53:4 54:19
166:3,4 174:19 176:19 177:7 179: nine [2] 20:1 291:7 240:16 307:20 55:1 83:3 91:9 121:8 169:16 187:
10,16,22 184:2,13 187:21 188:6 NK [1] 60:14 number [37] 14:8 17:17,19 25:17 11 206:21 212:9 230:10
190:7 192:3 197:3 198:2 199:18 Nobody [1] 125:13 26:20 39:10 41:20 49:14 66:7 67: one [146] 8:18 11:6 13:11 15:19 17:
200:3,15 201:8,14 202:3,7 203:3, nodding [1] 272:6 12 69:1 76:7 102:7,8 125:13 130: 22 18:10 20:11 27:15 29:19,20 32:
11 210:1,21 212:11 214:18 215:7, nodular [1] 66:22 22 142:15 152:3 168:8 172:6 174: 17 37:21,22 39:9 40:14 43:20 45:
19,20 217:5 220:4,9,11,16 229:11 non-A/non-B [1] 191:5 8 186:21 188:4,5 189:11 190:3 9,14 53:15 56:6 61:19 64:11 65:
230:14 234:3 237:19 238:22 239: non-alcoholic [1] 46:12 212:18 217:2 220:16 245:16,20 20 66:12 69:17,22 70:12 73:5,7,8
13 242:3 243:1,10,16 246:19 247: non-C [1] 74:12 258:9 268:13 286:13 290:11,11 74:11 76:11 77:4,5,21 78:15 79:1,
13 248:10 249:22 258:12 260:2, non-fibrotic [1] 69:9 302:11 5 80:11 88:19 89:22 94:19 95:3
18 261:11 266:10 267:2 268:22 non-Hispanic [7] 21:21 71:20 72: Numbers [6] 19:7 35:12 41:21 48: 96:8 101:20 103:4 107:6 113:7
280:8 284:1 285:5,7 289:1 294:15 6 304:6,7,14,14 13 263:19 296:22 115:20 117:14 118:17 119:19 122:
295:15 296:12,19,21 299:11,16 non-immunosuppressed [1] 46: numerous [1] 274:22 8,15 123:9 124:4 125:4 127:17
301:3,5,8 303:9,14 305:18 309:19, 12 nursing [1] 23:2 129:13,14,19 130:5,21 135:8 144:
20 310:4 312:1,13,18 non-inferior [2] 132:17 253:18 NUY [1] 84:16 7,13,19 147:20 155:10,11 158:4,
needed [5] 109:18 206:16 232:10 non-inferiority [12] 79:10 248:18 12,17 159:18 160:2,3,16 171:5
256:21 263:3 249:9,12 251:14 252:6,13,16,19
O 174:20 175:20 176:22 177:2 178:
needing [1] 291:5 256:13 257:2,18 o=clock [3] 15:19 171:4,5 11 179:18 182:14,15 186:22 188:
needles [2] 67:14,17 non-injecting [1] 24:18 o=clockB-is [1] 301:22 17 189:2 192:11 194:19 198:9
needless [1] 138:14 non-interferon-based [3] 122:14 obesity [1] 46:5 200:18 202:13,17 205:12,14 206:
needs [16] 54:20 69:22 80:7 94:2 124:2 136:9 objectives [1] 7:1 15,20 212:20 213:1 218:7,16 221:
96:4,16 120:7 139:12 195:15 199: non-invasive [3] 101:15,19,21 obligated [1] 14:22 20 222:16 224:6 226:17 229:9
17 201:17 225:17 232:16 246:18 non-nucleosides [1] 260:4 obligation [1] 215:14 231:6 234:1,21 239:21 240:20
308:16 309:1 non-pegylated-interferon [1] observe [1] 182:8 252:20,21 253:1 256:4 262:1 263:
negative [13] 26:10 35:11,11,11 254:21 observed [3] 19:10 32:20 183:9 7 264:14 265:4 267:4,7 270:15
40:15,18 70:14 123:18 147:2 175: non-placebo [1] 150:3 obstacle [2] 291:10,11 272:1 275:20 279:4,14 280:1 281:
19 181:10 243:4 265:11 non-responder [15] 115:18,19 obtained [1] 8:5 10 282:2 290:8,11 291:4,21 298:9
negativity [2] 70:9,11 116:15 117:21,22 124:22 134:14 obviate [1] 254:10 299:7 302:2 303:13,14,18 305:11
neighboring [1] 82:5 138:14 143:19 178:18 235:3,17 obviously [28] 69:17 78:12 82:12, 306:17 308:6,17,22
neighbors [1] 20:5 236:18 237:4 239:12 18 93:16 96:8 110:8 115:15 118:2 one-by-one [1] 229:22
net [2] 210:7 274:5 non-responders [34] 65:5 75:10 123:4 128:9 134:16 152:10,22 one-stop [1] 206:19
never [3] 95:8 240:7 276:4 76:5 113:18 115:14,15 116:6,19 156:11 178:4 191:22 192:14,22 one-way [1] 158:20
New [77] 5:5,16 10:17 11:4 22:4 31: 125:17 134:7 139:2 140:21 141:3 199:21 211:6 213:16 228:8 236:9 ones [4] 43:15 239:4 273:9 295:13
6 32:4 43:10 50:4 51:14,17,19,20 148:2 149:8 166:15 168:18 178:9, 238:7 279:15 280:7 291:6 ongoing [17] 57:18 90:4 110:9
11,14 179:7 190:11 193:12 194:2 occasion 155:21
[1]
55:22 57:17 64:22 72:16 75:8 77: 147:12 149:7 162:3 177:18 180:
8,13,15 80:12 81:13 82:16,20 83: 200:11,12 201:18 235:20 236:20 occasional [1] 163:9 10 183:2 215:21 216:3,13,18 217:
9 86:1,6 87:9 89:16,20 94:14 95:3 237:8 239:20 240:15 243:2 287: occult [1] 126:8 21 224:20 233:8 264:14
98:4 102:4 103:3,7 109:17 117:7 17 occur [11] 10:18 22:7 27:12 42:9 ongoing-Blet=s [1] 136:11
118:16 133:2 138:16 143:8 153: non-response [8] 40:1 42:19 64: 43:13 65:9 112:5 160:4 170:1 187: only [34] 43:20 46:14 56:14 65:20
20 158:11 160:20 169:9 174:18 20 66:2 68:22 69:20,22 70:3 17 222:6 66:6 68:10 114:3 117:5 122:10
175:8,12 176:9 177:3 179:6 187:3 non-responses 307:21
[1] occurred [1] 102:16
139:12 140:5 145:21 149:10 153:
non-responsive [3] 70:2,5 308:9 occurring 32:5,13
[2]
189:22 191:14 194:4 206:21 210: 4 157:18 159:14 161:19 165:16
12,14 217:19 218:19 221:3 242:2 non-structural [2] 55:10 61:2 occurs [4] 72:4 160:14,20 161:3
187:3 206:22 219:19 225:5,6,7
247:9 250:11,16 256:12,15,22 Non-Voting [3] 2:10,19 8:15 October [2] 1:7 313:2 249:10 254:13 255:9 257:13 265:
266:15 276:16 290:3 291:3 303:7, none [3] 122:3 128:1 167:6 off-label [2] 289:9 298:16 11 272:18 279:7 293:15 294:21
12 304:2 noon [1] 171:11 off-treatment [2] 131:7 268:3
306:9
newer [4] 117:9 140:2 157:4 285: normal [7] 26:11,15 32:10 47:1 offer [4] 163:4 213:15 241:2 311: OPEN [9] 1:5 3:27 15:19 171:6,15,
20 110:21 111:1 162:2 12 17 172:14,19 308:17
newest [1] 54:17 normalization [1] 125:7 offered [12] 83:5 124:5 125:4,13
Opening [2] 3:2 4:2
news [6] 86:19 89:15 90:6 108:12, North [2] 66:9,14 129:9,10,15 130:21 138:19 140:7 opinion [11] 107:7 121:7 175:21
14 109:18 Northwest [1] 286:7 217:13 279:4 176:15 198:8 205:13 208:7,15,21
next [24] 10:10 37:12 48:22 50:7, note 23:3 56:20
[2] Office [1] 8:6
280:16 303:18
18 83:16 95:9 149:17 158:1 168:1 noted [3] 9:2 125:17 187:7 Officer [4] 3:25 5:10 6:5 180:7 opinions [4] 107:9 115:13 122:4
notice [4] 16:4 107:10 116:16 182: offices 87:5 126:6
[2]
180:3 190:16 191:10 203:8,14 211:21
216:6 233:10 238:3 244:19 256: 3 often [16] 25:5,20,22 32:7 38:12,22
opportunities [1] 51:21
17 258:2 274:19 285:11 287:22 notorious [1] 266:21 41:13 86:17 114:11 150:21 153: opportunity [10] 80:14 108:15
NHANES [2] 22:19,22 notoriously [1] 281:20 14,15 161:2 221:5 282:13,15 138:16 142:11,17 171:7,17,20
novel [25] 117:7 119:12,16 124:8, okay 131:18,19 203:6 226:8
[9]
NIAID [1] 198:13 180:1 276:5
nice [2] 58:15 304:18 11 130:19 131:22 132:13,20 133: 244:18 257:21 269:2,22 284:13 opposed [6] 111:19 154:13 184:
12,21,22 134:9 138:16 140:20,22 old 82:16 190:8 299:9,10,11
[7]
nice.@ [1] 125:14 22 238:9 302:15 303:6
nicely [1] 84:6 141:13 152:22 159:18 160:13 180: 300:2,2 opt [2] 137:3 249:20
older [1] 21:20
Sheet 17 need - opt
opted [1] 141:20 outcome [12] 39:4 42:11 53:16 54: partially [2] 30:21 68:11 19 280:4,7 281:13 282:14 283:8
optimal [2] 68:2 290:4 1,9,21 116:14 149:13 168:6 224:9 PARTICIPANTS [7] 2:1 8:22 9:1, 284:8 285:19 290:5 292:2 293:5
optimist [1] 83:11 253:2 279:19 3,21 194:12 241:18 298:11 301:11 311:2,3,8,9
optimistic [2] 133:15 136:5 outcomes [3] 43:2 44:17 233:6 participate [1] 137:18 patients= [1] 128:6
optimistically [1] 280:1 outliers [1] 42:15 participating [2] 7:21 8:14 pattern [1] 236:15
option [4] 129:20 140:5 179:12 outline [1] 107:17 participation [1] 137:20 patterns [2] 64:20 133:11
217:17 outlined [1] 68:22 particular [22] 7:7 8:18 19:22 22: pause [1] 132:22
options [5] 102:19 113:2 129:18 outside [7] 8:2 67:22 172:3 180:9 11 30:16 31:9 33:22 72:16 74:22 pay [1] 288:19
140:14 268:4 198:12 294:22 295:2 79:7,8 93:3 121:15 159:5 168:6 paying [1] 102:17
oral [12] 94:19 97:7 100:15 101:3,6 outstanding [2] 190:21,22 205:12 206:6 219:8 242:16 258: payment [1] 173:3
104:4 130:16,17 172:20 176:17 over [33] 10:3 19:14 27:11,12 29: 17 261:16 312:14 PCR [1] 70:11
291:6 292:14 13 36:12 37:11 46:1 48:22 50:19 particularly [22] 19:13 25:4 27:9 peak [1] 21:16
Order [11] 3:2 4:2,4 68:8 142:19 74:5 86:13 87:1,2,11 100:15 107: 35:19 45:2 60:6 67:15 79:19 91:4 peaks [1] 48:16
161:10 192:9 200:7 229:18 296: 20 110:12 112:7 117:10 129:19 146:20 158:13 178:3 188:21 190: pediatric [12] 4:20 5:1 112:2 115:
13 309:21 133:13 150:16 170:15 175:22 248: 4 220:20 238:13 246:8 248:2 267: 1 164:10 180:14 285:14,19 286:
organ [6] 204:10 217:13 225:8 276: 21 254:18 263:7 286:2,10,15,15 20 268:12 275:18 285:13 21 287:11 290:4 298:15
9 279:4 280:8 289:3 partly [2] 208:20 274:4 pediatricians [2] 289:20 290:4
organization [2] 84:15 86:5 over-call [1] 160:12 partners [2] 24:10,11 pediatrics [16] 13:16 112:1 114:
organizations [2] 87:6 88:18 over-representation [1] 21:20 parts [4] 17:10,11 245:17 247:19 20 154:20 164:3 258:13 285:11
organs [2] 23:18 276:10 overall [7] 25:14 71:5 148:14 230: passes [2] 89:6,11 287:22 289:15,19,21 290:11,17
orient [2] 51:7 74:19 15 249:16 271:21 310:10 past [5] 87:1,8 114:9 148:7 186:19 292:22 295:15 300:5
original [5] 152:2 215:18 224:21 overcome [1] 200:19 pathogenesis [3] 51:10 52:7 303: pedigree [1] 240:17
229:3 232:13 overlap [1] 210:2 10 pedigreed [2] 236:12,17
orphan [1] 215:4 overlaps [1] 273:7 Patient [62] 2:17 12:19 13:5 14:3, pedigreeing [1] 178:19
other [115] 8:21 9:3 11:16 17:11 overly [1] 240:10 12 15:7 19:11 20:11 25:18 33:22 peer [1] 50:18
18:14 19:22 20:5 24:4,17 29:21 overnight [1] 86:17 34:13 35:1,6,6,8,13,21 41:13 42: peers [1] 189:5
30:4 34:16 35:5,16 46:13 52:2,12 overview [2] 16:19 285:13 13,21 44:21 51:19 64:21 70:21 74: PEG [11] 36:9 84:18 91:20,22 100:
55:15 59:8 60:10 78:5 80:21 86: overwhelmed [1] 92:15 4 78:14 87:3,12 90:9,15 115:3 11,18 103:3 104:5,21 151:7 288:1
10,15 94:4 98:14 99:18 103:4 104: overwhelming [1] 298:19 116:1 121:8 126:22 127:13 134:2, PEG-interferon [4] 41:3 42:5 287:
13 107:5,8 113:16 114:1 115:2 owing [1] 73:2 4 137:7 144:21 153:8 166:10 181: 21 291:13
117:2 118:10,15 122:4 128:9 130: own [6] 198:17 201:22 242:4 248:7 21 182:17 192:13 193:10 194:6, PEG-interferon-ribavirin [2] 94:
7 131:12 132:1 135:20 149:1 151: 271:8 285:16 13 196:21 197:11 204:18 206:15 15 234:5
15 157:14 158:15 160:10 163:10 208:5 209:10 210:7 219:19 241:6, PEG-ribavirin [2] 84:19 308:4
164:15 165:3,7,13 173:4 182:20
P 15 242:17 259:13 278:22 281:7 pegylated [17] 11:12 13:22 14:18
184:5 193:13 196:5 204:11 207:9 p.m [3] 1:8 171:13 313:1
283:6 34:14 71:2 73:15 115:22 116:10
210:3,10 213:12 214:4,6,7 215:17 P450 259:6 261:20 268:16
[3]
patient=s [1] 27:8 118:1,9 130:2 131:10 148:5,10
219:21 220:9,19 222:10 232:5 Pacific [1] 286:7 patients [218] 10:19 13:1 23:2,19, 149:1,3 254:20
233:3 237:15 238:19 239:4,6 243: package 271:15 294:9
[2]
20 24:9 26:2,22 27:7,12 34:9 35:4 pegylated-interferon [7] 287:13,
22 244:1,22 245:17 247:19 249:7 page 8:1,2 17:3 142:22
[4]
36:21 37:2,11 38:1,22 40:9 43:15 15 288:5,9 290:14 294:17,19
252:16 257:16 259:4 260:17,22 paid [3] 92:19 234:15 289:10
45:12,17,22 46:1,4 47:8,9 48:14 pegylated-interferon-ribavirin
266:13,15,18 268:1,6 272:2 277:2, paired 239:3,5
[2]
51:3 52:15 53:7,15 58:11 61:13 [1] 134:11
12 278:19 279:15 282:2 283:2,18 panels [1] 95:7
64:8,9 65:19 66:19 71:15 76:7,14 penchant [1] 125:21
284:20 286:11 287:2,10 288:2 paper [2] 26:19 41:2 77:10,12 78:2 79:13 80:3,20 82: pending [1] 177:12
290:8,9 291:4 292:3 295:21 302: paradigm [6] 14:16 39:10 95:4 19 86:22 93:3 102:11 110:15,18 penicillin [2] 83:4 251:4
14 305:4 307:21 312:1 162:17 240:16 280:12 111:3 112:2 115:6,9 116:18 117:4, people [128] 4:14 17:18 20:2 22:8,
other=s [1] 56:15 paradigms [2] 37:13 82:16 8 118:7 119:7,18 121:11 123:13 12 23:1 38:19 47:13 55:16 56:22
others [15] 12:11 78:13 92:4 136:7 parallel 37:1 261:22 262:12
[4]
126:5 127:1,20 128:1,5 130:4 134: 86:7,8,14 88:2,11 91:10,19 92:1,4
146:3 151:6 195:19 206:8 213:5 263:3 4,17 135:21 136:1,15 137:2,5,22 93:3,4 94:10 95:6,12 98:4 99:3,5
221:15 239:16 274:10 286:10 293: parameter [4] 31:2,6 37:22 43:9
138:11 141:16,19,21 142:2 143:1, 100:10 101:5 102:11,14,18 103:
1 310:1 parameters [4] 40:1 41:5 43:7 9,12 145:7,11 150:8,17,22 151:11 19 104:8,10,14,17,21 112:14 142:
otherwise [4] 95:17 103:14 141:6 266:13 152:3 153:13,18 154:22 160:1 15 147:4,11,21 148:3,6,10,15,18,
255:12 paraphrased [2] 49:20 222:15 164:20 165:1,1,3,18 167:5 168:5, 19,20,21 150:9 152:10 171:6,19
ought [3] 159:11 262:20 307:22 paraphrasing [1] 302:18 19 174:15,17 175:22 176:2,3 177: 172:8,9 186:22 187:11 199:4,15
ourselves [2] 221:15 294:15 parenchyma [1] 67:22 9 178:2,3,5,6,13,19 179:1,3,7,12, 200:13 201:2,6,17 203:1 205:17
out [63] 23:17 27:4,8 30:7 32:6 33: parenteral 118:8,20
[2]
21 181:16 182:1,3,6,8 183:1 184: 206:1 212:12 214:1 215:7 216:21
9 58:9 66:18 77:7 84:12 94:3 96: parenthetically [1] 49:20 4 187:9 190:12 191:17,18 192:3, 219:21 220:1,5,16,18 222:10,18
14 97:3 102:16,19 105:17 136:1,3 Parklawn 8:7
[1]
14 193:6,14,15,16 194:3,7,9,12,17 223:7,11 226:5 230:8,22 231:17,
137:8 144:20 147:5 158:11 162:7 parroting 302:7
[1]
195:3,10,22 196:8,15 201:22 203: 19,21,21 239:20 240:7,12 241:2
164:22 172:9 183:8,21 191:16 part [32] 6:16 30:7 38:15 52:20 96:
5,9,10 204:2 207:5,10,13 213:13 242:5 244:12 245:3 258:1 260:17,
196:6 199:19 200:8,15 204:22 12 107:10 108:3 112:5 113:1 138: 214:17 216:2 217:22 218:12 222: 21 261:15 264:20 265:19,19,21
217:2 220:15 222:7 227:4 230:10 12 145:18 152:12 163:18 191:13 4 224:3 232:12,14 233:1,12 234:5 266:8 269:14 271:13 273:1 275:
239:4 243:11 257:21 263:8 268: 192:15 193:8 223:11 224:4 229: 236:11 238:5 241:17 244:2,7,8 22 276:3 283:9 285:10 288:19
13 269:13 270:7,17 272:10,14,20 18 232:2 235:9 237:5 244:3,17 247:16 249:18,20 252:17 259:8, 289:1 292:10 296:12 297:19 302:
281:14 283:10,15 284:2 285:8 256:21 262:15 269:5 281:3 287:8 18 267:20,22 268:4,10,18,20 269: 11 306:3,15,18 309:19,20 310:2,
289:8 293:8 296:15 299:4,20 300: 289:18 292:21 294:19 8 270:10 272:3,5,16 273:8 274:2, 15 312:10,15,17,20
20 308:15 310:5,6 partial [5] 116:20 192:5 193:4 235: 3 275:6,8,14 276:7 277:11 278:19, peopleB-I [1] 223:6
18 236:21
Sheet 18 opted - peopleB-I
peptides [3] 55:10 56:1 182:12 pestiviruses [1] 18:10 plans [1] 177:15 225:20 227:13 229:14 230:7,13,
per [9] 10:21 19:6 22:4,14 48:4,5 Peter [3] 2:8 5:1 242:9 plaques [1] 10:1 14 232:15 233:9,22 234:2,16 235:
54:15,17 160:6 Peter=s [1] 158:3 plausible [1] 262:1 4,14,15 236:8,8 237:4,5 238:7
percent [79] 30:20 31:8,8,9,9,20 Ph.D [6] 2:2,9,14 3:3,13,29 play [1] 218:6 239:15 240:17 243:6,10 248:19
33:7,8,20,21 34:1,3 35:8 43:19 44: Pharm [1] 3:6 playing [2] 69:7 207:2 259:13 261:10 262:9,20 264:4
22 45:2 46:14 48:4,5 53:15 54:14, pharmaceutical [2] 44:10 210:16 plea [2] 195:18 311:7 265:3,5 267:5,10 270:18 273:2,13
17 55:3 58:16 64:15 65:9,10,21 pharmacodynamics [1] 222:13 pleasant [1] 231:8 279:5,9 281:7 286:21 287:5 288:
66:8,10 71:7,8,9 72:7 74:5 75:21 pharmacogenetics [1] 98:12 please [7] 4:11 173:16,19 186:13 22 297:18 299:13 300:3,6 304:16
88:2 109:14 113:15 116:9 117:10, pharmacokinetic [4] 260:3 264:7 197:15 216:1 305:9 308:20 309:6 311:19
21,22 121:18 123:20 127:3,21 266:17 285:1 pleased [1] 198:22 population-specific [1] 305:19
128:5 136:2 144:15 148:14,15 pharmacokinetics [6] 224:17 pleasure [1] 50:17 populations [92] 7:4 12:19 13:6
149:5 165:1 174:16 175:17 176:1 227:14,20 268:12 301:7,14 plot [1] 31:13 19:13,14 21:1 22:21 27:10 36:17
181:22 191:21 199:1,6,11 217:11 pharmacologic [1] 50:22 Plough [5] 3:28 174:2,4 179:14 45:2 50:10 51:19 64:21 66:14 75:
228:16,16 231:11,18 238:10 240: pharmacologically [1] 42:2 291:16 12,15,17 76:13,15,18 78:10 87:3,
14 247:11,14 248:21,22 274:17 Phase [34] 12:20 31:18 32:3,8,15, plunge [1] 107:22 21 88:13 90:11,15 91:4,9 92:2 93:
286:2 306:17 310:9,10 311:11 17,19 33:15 35:7,10 36:12 37:1 plus [8] 14:18 77:8 94:15,16 103:3 1,2,7 98:9,13,21 99:6 111:7 117:5,
percentage [9] 22:9 45:5 91:18 48:11 72:3 94:20 97:6 101:8 114: 149:4 242:2 287:14 16 119:12 121:2 134:2,5 135:11
194:17 195:21 286:3,22 307:9,12 14,21 159:21 183:22 184:12 211: plus/minus [2] 94:14 256:12 141:5,15 177:4,13,13,16 188:21
percentages [2] 69:14 287:2 15 212:9 215:22 230:11 232:19, point [77] 20:7 26:13 28:6 33:14 189:10 196:21 206:1 208:6 210:1,
perfect [4] 240:17 261:13 305:17 19,20 257:6 270:13 282:8 305:18, 37:22 44:8,8,16 45:18 46:18 52:3 20 211:2 212:2,8,18,20,22 213:3
310:13 20 63:16 64:2,15 66:8 77:7 85:16 88: 226:1 229:11 230:4 233:15 234:7
perfectly [1] 281:14 phases [2] 154:12 241:20 14 97:13,15 98:5 101:2,16 103:10 237:1,4,16 238:22 242:20 243:21
performed [1] 156:4 phenomena [1] 204:22 144:18 146:4 149:18 152:11 155: 251:1 262:10 263:21 270:20 285:
perhaps [60] 32:16 52:22 63:6 64: phenomenon [1] 65:15 6 156:8 157:14 159:6 168:1 171:1 14 297:4 298:15 308:8 309:9,10,
13 69:8 72:14 85:20 97:6,19 98:2, Philip [3] 3:30 186:12,16 176:20,21 177:15 189:2 191:16 16,22 310:3,13 312:2,12,15
15 101:20 111:18 112:17 114:13 phosphorylated [1] 62:8 192:15 197:1,2 202:22 203:3 206: populationsB-the [1] 69:14
117:10 122:3 123:6,12 124:14 phrase [3] 229:10 232:8 296:18 14 210:9 211:14 212:17 214:22 pormise [1] 92:6
125:10 131:14 140:1 141:15 143: PhRMA [1] 262:15 223:13 226:20 231:9 232:4 237: portal [7] 47:16 67:13,19 68:1 167:
9 146:20 147:18 152:17 155:1 phylogenetic [2] 19:19,20 20 239:19 240:2 242:9 244:16 8 195:13 205:1
156:9 157:18 161:13 163:13,15 physical [1] 293:15 246:21 250:3 253:14,20 254:22 portends [1] 287:4
169:20 181:9 184:16,17 210:1,5,7, physicians [4] 201:4 207:7 272: 267:4 271:2 288:15 289:6,13 290: portions [1] 25:15
14 211:9 220:18 222:5 225:21 22 310:1 9 292:20,20 298:4 299:2 300:1,20 posed [8] 14:8 106:20 107:15 110:
235:13,17 236:3 240:3 241:8,21 physiologic [1] 47:19 310:6 311:13 1 111:12 115:12 171:9 216:11
242:12 250:21 253:1 274:2 281: pick [1] 233:17 pointed [8] 58:9 66:18 147:5 183: position [2] 243:19 290:3
13 285:12 298:12 307:17 picture [3] 17:6 28:7 47:16 8,21 191:16 196:6 204:22 positive [9] 18:8 23:21 24:11 26:8
period [25] 22:5 27:12 38:13 39:14 piece [2] 216:13 293:7 pointing [1] 270:17 117:11 136:14 178:16 229:18 266:
40:11 45:7,18 63:14,21 67:5 68: pieces [1] 135:19 points [16] 11:3 20:6 43:3 81:10 5
12 114:18 115:10 128:3 131:6 piercing [1] 24:19 90:18,19,21 108:6 124:13 165:8 positively [1] 293:14
133:13 134:10,12 136:13 147:2 pike [1] 285:21 181:1 187:4 203:7 229:22 290:9 possibilities [1] 169:16
157:19 158:21 230:22 238:20 252: pill [1] 291:8 310:8 possibility [7] 129:16 144:16 169:
17 pills [1] 291:8 politician [1] 146:16 22 222:17 239:22 240:4 296:8
periodic [1] 141:22 pilot [16] 212:17 216:2 217:20 222: poly-drug [1] 99:4 possible [25] 80:14 82:1 103:21
periods [7] 26:10 119:13,17 130: 2 226:22 227:1,10 229:10,13,17 polyclonal [1] 55:13 107:7 112:13 120:13 123:3 131:
12 157:17,21 169:4 230:3,12 254:6 262:20 263:6 268: polymerase [7] 12:8 19:8 94:16 20 136:20 139:5,6,21 189:1 197:4
peripheral [2] 183:16,19 19 95:17 102:8 145:17 153:7 199:18,20 200:7,9 201:13 207:3
Perleson [1] 42:6 pipeline [1] 12:1 polymerases [1] 176:10 221:14 225:10 281:2 298:7 311:
permit [1] 164:13 pivotal [6] 40:14 41:3 131:21 270: pool [6] 27:15 28:5 31:22 44:5 79: 17
permits [1] 38:7 11 309:3 310:12 2 178:13 possibly [10] 14:13 52:11 127:22
perplexing [1] 76:19 PK [22] 206:6 222:5,12 225:22 226: pooled [2] 34:10 192:19 128:14 129:10 132:17 158:21 159:
persistence [1] 57:16 12 227:12 261:20 262:20,22 263: poor [4] 202:9,9 266:21 275:13 1 239:11 296:7
persistently [2] 53:21 70:14 18 288:16 296:21 297:5 298:4 poorly [4] 27:17 76:2 174:22 191: post [43] 13:13 39:16 64:16 68:17
person [6] 48:1 84:19 115:20 147: 299:8,10,12 300:9 301:19 305:12, 18 71:14 76:16 77:21 80:9 88:12 93:
2 198:3,5 19 311:22 populated [1] 305:21 5 100:7 127:6 128:3 138:7 144:21
person=s [1] 53:11 PK/PD [2] 227:5 285:18 population [128] 10:16 14:3,12 15: 221:17 226:10,10,11 228:9 258:
personal [5] 75:14 82:17 104:18 place [8] 33:8 41:15 101:17 177: 8 19:15 21:18,18 36:5,9 42:13 54: 10 273:6,10 274:7,13,14,16 275:9
198:17 201:22 17,17 276:11 282:6,10 15 55:5 63:2 65:17 69:19 72:16, 276:8,12,17,19 277:18 278:9 279:
Personally [3] 77:10 201:7 291:20 placebo [15] 13:21 77:9,11 78:4 22 73:1,5,10,11 74:21,22 78:11 13,18 280:14,21 281:9 282:8 284:
personnel [1] 24:1 79:15,16 118:12,20 119:3,10,20 80:10 88:9 90:10 91:14 94:1 98:7 6,10,18
persons [1] 269:10 130:17 139:6 143:6 150:3 99:20 108:21 109:15 113:8,12,21 post-approval [1] 114:18
Perspective [17] 3:8,20,24 9:11, placebo-like [1] 134:10 114:2,9 115:3,4 116:15 124:22 post-market [1] 124:6
14 10:13 15:17 82:17 83:19,20 84: placed [2] 106:22 277:12 138:10,14 145:12,22 146:9 151:9 post-marketing [5] 114:14 154:
5 106:8,15 107:11 138:8,9 300:8 places [2] 20:17 43:21 153:9,17 162:4 163:8 187:7 188: 13 212:14 230:22 285:4
persuade [1] 167:17 placing [1] 195:3 19 189:1,3 190:13 193:19 194:21 poster [2] 104:16,19
pertinent [2] 62:3,16 plan [3] 235:4 243:2 307:22 197:11,19 199:14 206:9 209:4,5, postoperative [1] 112:1
perturbation [2] 30:1 31:17 planned [1] 232:6 15,20,21,22 210:13 211:6,8 213:8 potency [2] 165:21 166:1
perturbed [1] 56:19 planning [3] 83:14 226:5 307:18 214:22 216:15 217:4,8 224:19 potent [1] 219:1

Sheet 19 peptides - potent
potential [23] 7:14 8:9,11 44:6,14 194:1 proceed [3] 91:1 122:2 293:12 9 91:15,16,20 95:16 102:7,15,16
67:8 69:4 79:13,15 81:11 102:9 presentations [1] 271:21 proceedings [2] 171:11 313:1 103:4,13,15 145:17 151:17 153:6
162:9 191:9 196:7 204:7,19 219:2 presented [5] 22:16 72:11 94:12 process [24] 22:1 23:17 25:4 28:7 260:5 266:17,19
241:11 277:16 279:12 280:11 282: 99:14 256:10 29:19 38:3 44:1 45:8 46:16 54:20 proteases [1] 176:9
2 293:11 presenters [1] 88:2 172:12 204:5 215:3 228:12,12 protect [1] 204:18
potentially [17] 81:14 132:14 133: presenting [4] 11:6 15:12 83:19 232:3,6 244:4 260:13,19 263:6 protected [1] 144:11
2,19 162:22 184:5 200:14 209:2,5, 184:10 281:4 296:6 298:6 protein [1] 61:18
11 210:11 213:18 222:12 246:16 president [1] 174:2 processB-is [1] 220:10 protein-mediated [1] 57:9
282:12 303:12 308:10 presumably [10] 30:1 49:15 65:13 processes [2] 96:21 249:7 proteins [6] 18:19,20,21 55:11 59:
potentials [1] 203:20 119:9 152:16 155:9 202:4 247:18 prodrug [1] 81:5 14 61:2
power [3] 213:7,9 238:11 273:20 279:18 produce [3] 28:4,6 266:5 prothrombins [1] 110:22
powered [2] 167:15 302:8 presume [2] 198:12 306:11 produced [3] 11:15 56:10,10 protocol [3] 210:18 215:1 281:10
practical [2] 7:14 66:6 presumptively [1] 282:12 product [7] 7:7 13:16 71:2 187:22 protocols [3] 106:18 122:3 280:20
practice [1] 311:9 pretreatment [2] 38:18 39:5 248:14 294:10 296:1 proud [1] 295:9
practices [1] 281:17 pretty [10] 35:2 84:6 85:5 88:18 production [18] 28:13,14 29:14 prove [6] 96:18 100:21 101:8 124:
practitioners [1] 288:19 100:5 105:22 218:18 238:18 273: 30:4,7,9,20,21 31:4,7 32:3 56:16 7 132:16 134:13
pre [14] 13:13 68:16 88:12 93:5 1 311:15 59:7 60:14 61:18 62:21 63:5 183: proved [2] 83:4 242:1
111:22 220:19 221:17 258:10 273: prevalence [7] 21:16 24:7,16 77:1 15 proven [4] 61:11 95:17 103:14
6 275:10 284:5,11,18 293:1 309:5 311:18 312:15 productive [5] 27:19 67:18 75:22 283:12
pre-approval [1] 271:15 prevalent [2] 20:20 99:6 77:12 189:18 proves [1] 297:18
pre-INDs [1] 12:7 prevent [6] 81:20 130:9 140:17 productively [2] 27:21 28:4 provide [11] 12:3 16:19 41:8 85:4,
pre-intent [1] 279:8 279:11,20 282:9 Products [18] 3:10,15,25 6:6,10, 11 86:20 117:15 205:16 214:20
preambles [1] 295:21 preventable [1] 50:21 21 8:21 9:6 10:12 11:10 12:2,5 21: 249:1 268:16
precede [1] 277:4 preventing [2] 154:1 282:6 4 50:13 134:22 138:17 177:3 306: provided [3] 28:17 173:14 274:10
precipice [1] 89:15 prevention [3] 82:10 167:11 282: 2 providing [3] 86:16,22 142:2
preclude [2] 6:16 173:11 22 Professor [1] 3:17 psychiatric [2] 312:11,17
precondition [1] 281:22 previous [3] 9:5 116:8 236:12 profile [9] 70:1 82:1 83:2 132:18 pt [1] 126:4
predicated [1] 70:20 previously [8] 108:2 115:5,20 148: 133:18 194:16 285:22 290:16 308: Public [16] 3:27 5:20 15:19 24:8
predict [8] 29:3 40:9 92:3 124:11 1,16 237:9 287:17,18 7 85:9,10 171:6,15,17 172:12,14,19
164:6 168:9 181:1 279:1 pricing [1] 234:11 profiles [2] 179:19,20 173:15 196:17 228:20 298:22
predictability [1] 268:17 primarily [6] 18:22 21:2 194:14 program [1] 210:19 publication [1] 128:3
predicted [5] 34:6,20 71:18 82:9 244:14 309:9 311:4 programs [2] 86:12 180:10 publications [1] 86:18
163:16 primary [21] 7:1 25:5 77:19 78:7 progress [9] 45:10,22 46:2 54:4 publicly [2] 194:18 234:13
prediction [4] 34:19 38:9,16 39: 79:17 82:6 120:4,11 122:19,20 66:20 78:22 88:4 174:13 298:19 published [10] 25:18 26:19 71:21
20 124:5 126:16 127:17 139:11 175: progressed [1] 268:5 97:16 129:5 146:3 147:14 148:13
predictions [4] 39:8 48:10 49:10 8,11 232:13 233:4 257:20 263:20 progresses [1] 46:18 153:20 164:21
169:19 272:21 progressing [2] 108:15 220:2 Pugh [3] 128:16 129:1,8
predictionsB-future [1] 48:21 principal [1] 74:13 progression [16] 28:22 45:20 46: purely [1] 70:2
predictive [6] 28:21 33:4 35:2 40: principally [3] 65:19 67:6 73:9 6,17 53:5 54:5 74:3 75:1 82:10 purine [1] 62:11
16 41:7 123:18 principles [1] 219:16 126:17 128:7 149:15 259:2 280:5 purpose [3] 137:12 156:7 173:12
predictor [1] 164:1 prior [18] 23:15 43:14 51:17 59:17 281:12 285:13 purposes [4] 65:15 77:5 110:6
predictors [4] 38:18 39:5 40:6 133:11 142:6,9 197:18 268:8 271: progressive [5] 187:8 274:15 284: 213:7
177:5 20 272:12 274:7 278:6,15 297:2,4 8 286:9 306:20 pursue [1] 248:11
predicts [1] 36:1 298:6 301:17 progressors [1] 281:9 pursued [1] 257:7
predominance [1] 20:17 priorities [1] 221:9 proinflammatory [1] 63:4 purview [2] 57:6 234:11
preexisting [1] 242:14 prioritize [2] 128:18 276:17 Project [3] 3:22 83:18 89:1 push [1] 300:9
preface [1] 107:18 priority [8] 75:15,22 76:17 129:2 projected [1] 196:1 pushed [1] 265:4
prefer [9] 139:18 155:8,12 156:3,4, 194:4 195:6 247:16 253:11 prolonged [2] 140:17 153:16 put [6] 10:13 92:13 124:8 210:18
6 187:16 189:16 289:16 prisoners [1] 23:1 promise [5] 124:6 226:6,11 227: 235:20 271:5
preferably [1] 187:18 pristine [1] 218:13 11,12 putative [1] 62:2
preference [1] 228:2 probability [2] 70:15 79:21 promised [1] 263:9 putting [5] 35:20 85:13 230:1 240:
preferred [4] 121:1 130:3 140:15 probable [1] 202:2 promising [2] 114:21 177:11 21 270:7
155:21 probably [42] 20:8,21 30:12 39:2 promote [2] 57:16 61:14
preformed [1] 61:19 59:4 77:19 84:17 86:14 87:9,10 prone [1] 103:14
Q
preliminarily [1] 72:11 93:22 95:8 127:11 136:18 137:11 prophylactic [1] 182:19 qualitative 25:10
[1]

preliminary [1] 274:11 138:6 143:21 152:5 169:3 176:1 prophylaxis [2] 282:22 284:10 quality [4] 43:3 82:13 252:3 293:
premature [1] 124:14 179:16 205:13 206:11 210:16 213: proportion 306:15 311:18
[2] 17
prepared [4] 7:17 9:7 156:9 190: 3 227:2 232:18 238:18 244:3 260: proportions [1] 308:12 quantifiable [1] 251:21
20 8 263:1,5,17 267:7 268:19 269:15 proposal [1] 263:7 quantification [1] 286:18
preparing [1] 126:21 277:1 278:3 286:19 298:1 307:9, proposals 192:11
[1] quantitative [1] 25:12
prerequisite [1] 197:18 10 proposed [1] 276:14 quarter [1] 306:17
prescribed [1] 116:9 problem [13] 30:19 53:6 67:10 68: proposing [1] 248:13 quasispecies [3] 19:13 20:9 242:
present [7] 9:10 15:16 71:13 126: 4 96:12 129:6 179:9 221:3 223:2 prospect 279:8
[1] 15
9 144:9 160:7 284:7 245:11 274:21 293:17 306:4 prospective [1] 254:16 question [72] 14:8 18:13 83:7 111:
presentation [9] 56:1 107:17 112: problematic [6] 67:15 79:12 80: prospectively [2] 215:5 254:14 6,19 142:11 144:8 145:4 147:7
6 161:5 172:17 180:19,22 183:8 12 121:5 241:16 275:12 protease [22] 12:8 85:4,8,13 86:4, 150:6 154:5,8 155:4 156:1,15 157:
6 158:16 161:8 163:11,18 164:5
Sheet 20 potential - question
166:2,13 167:19 168:14 169:8,13 16 237:10 238:9,10 247:10 255:5, receive [3] 109:9 138:12 141:17 21 67:8 162:18
178:11 179:11 195:15 197:9 198: 6 256:5 266:3 274:18 310:10 received [11] 23:14,18 85:9 116:8 regarding [12] 69:1 78:14 82:19,
1 200:6 208:10 211:14,17 212:1 rates [19] 11:15 22:17 43:21 45:4 118:20 148:11,22 149:3 191:20, 21 98:10 111:6 138:21 185:16
216:11 220:3,13 221:9 225:13 71:5 73:19,20 143:4 174:21 187: 21 214:21 189:11 234:6 244:5 277:15
226:3 233:10 240:12 243:8,14 13 198:22 240:13 249:16 256:1 receiving [1] 77:14 regardless [1] 208:12
244:6,19 246:3 247:12 248:8,10 271:22 275:8 291:12 294:1 302: Recent [4] 21:14 39:22 40:4 98:1 regeneration [4] 28:1,2 43:13 67:
249:9 258:14,19 264:12 265:7 20 recently [1] 71:21 1
266:20 267:14 269:4 272:11 277: rather [13] 70:3 114:4 121:21 211: receptor [1] 12:10 regime [1] 189:15
14 280:15 282:15 284:15,15 292: 22 212:5 225:19 237:12 240:20 receptors [1] 59:11 regimen [20] 14:14 78:18 81:16
16 293:20 305:22 306:1,21 242:1 257:19 273:11 299:4 308: recess [2] 106:5 258:4 121:12 124:13 134:9 150:16 158:
questioned [2] 14:20 15:3 15 recessed [1] 171:12 14 159:15 191:13 193:8 208:13
questions [29] 12:16,17 15:20 36: ratio [1] 188:20 recipients [2] 136:16 146:1 249:5,19 253:5,17 256:14 266:20
19 95:1 97:1,2 106:20 107:2,14 rationale [2] 81:13 260:20 recite [1] 7:14 278:12 303:7
109:22 111:12 114:12 115:13 137: ravage [1] 112:11 recognition [3] 44:13 190:13 301: regimens [14] 63:10 77:9 115:21
21 138:20 142:8,20 144:19 149: Ray [8] 16:7,8 89:19 151:2 220:18 8 151:8 159:9,18,18 162:18 163:4
11 154:16 159:4,5 169:7 171:9 233:18 251:12 281:5 recognize [10] 47:8 52:8 80:12 87: 194:5 195:21 207:12 275:3,4
195:7 196:19 197:2 200:18 Raymond [2] 2:16 7:18 19 181:7 188:8,19 189:6 283:4 regions [3] 204:3,8 225:7
Questions/Clarifications [2] 3: re-emergence [1] 162:10 295:16 register [3] 172:7 177:2 285:6
26 142:5 re-prove [1] 122:13 recognized [3] 26:1 188:14,18 registered [1] 249:3
Questions/Discussion [2] 3:32 re-transplantation [1] 276:3 recognizing [1] 76:18 registration [21] 211:15 224:4
196:16 reach [5] 33:14 279:3 309:15,22 Recombinant [1] 25:8 226:10 229:19 232:13 233:16 237:
quickest [1] 205:16 310:3 recomendationB-that [1] 137:5 6 239:15 243:18 244:18 258:20
quickly [15] 27:21 35:12 46:2 105: reaches [1] 86:13 recommend [1] 93:8 262:21 265:9,11 270:17,21 278:6
15 108:4 133:3 160:21 195:17 reaching [1] 195:12 recommendation [3] 137:4 232:9, 281:3 283:15,22 296:8
199:18,20 200:7 220:1,14 222:8 read [5] 6:12 89:8 171:18 172:9 21 registrational [12] 114:8 138:12
281:2 245:4 recommendations [3] 87:17 185: 221:21 222:8 223:15 225:20 227:
quite [17] 48:19 64:7 72:2 77:1 85: readily [4] 53:17 54:7 184:4 251: 4,7 7,9 263:4 288:18 295:17 297:16
15,18 111:10 160:14 174:12 182: 21 recommended [8] 134:12,19 139: registrationB-initial [1] 243:17
10 183:6 190:10 282:13 286:5 ready [2] 206:16 241:21 5 141:14,19,21 196:22 249:4 registry [1] 146:1
290:5 291:6 296:5 real [12] 20:15 42:20 43:2 188:4 recommends [1] 24:5 regular [1] 150:19
quits [1] 179:11 226:10 237:7 250:4 282:4 289:11, reconvene [6] 106:4 171:5,12 258: regulated [1] 8:16
quote [1] 49:19 11 292:9 295:17 2 312:4 313:2 Regulatory [7] 3:23 106:8,14 107:
real-live [1] 312:19 record [5] 6:16 9:2 100:6 104:6 10 138:8 177:7,11
R real-world [1] 189:4 198:18 reinfected [1] 152:20
RAC [1] 84:16 realistic [3] 189:2 260:11 263:1 recorded [1] 123:19 reinfection [3] 144:17 282:6,10
race [2] 71:19 199:11 reality [4] 269:13 289:12,14,19 recording [1] 173:12 relapse [11] 65:8 75:9 121:19,19
racial [10] 13:18 76:12 112:19 258: realize [5] 101:18 188:6 189:4 242: recurrence [4] 160:20 161:2 276: 127:3 147:4 160:3,4,14 192:14,18
14 301:22 302:3 303:13,19,22 18 308:6 1 279:17 relapsed [3] 190:11 192:6 237:10
311:17 really [73] 17:2 21:22 32:12 35:19 recurrent [7] 74:3,15 80:9 274:8, relapser [1] 235:18
radio [1] 89:20 37:20 39:19 52:3 63:19 65:4 79:8, 16 276:8 279:11 relapsers [7] 76:9 116:21 117:10,
radiology [1] 67:16 10 82:15 92:11,14 95:20 97:14 recurring [2] 122:9 135:21 19 139:1 192:18 240:7
raise [5] 101:10 103:16,18 211:7 118:3 127:19 136:10 144:20 145: recurs [1] 279:13 relapsers/rebounders [1] 116:
235:2 1 151:10 154:9,21 158:2,13,16 red [1] 65:6 22
raised [7] 149:11 178:7 193:22 159:16 160:11 162:12 163:13 166: reduce [8] 51:4 127:6 169:22 183: relate [2] 61:4,6
223:7 259:5 309:1 310:16 4,8 174:6 184:1 190:19 193:5 195: 15 184:16 255:7,15 256:3 related [16] 7:2 10:11 12:7,17 18:9
raises [4] 150:1 169:15 201:11 2,7,19,22 196:3,8,11,12 200:10 reduced [8] 82:11 126:19 149:14, 20:4 21:3 49:1 73:8 88:15 158:18
277:14 201:17 202:3,16 214:6 218:22 15 162:16 178:22 255:17,18 258:13 268:12 273:12 309:8 310:
raising [2] 36:19 210:9 219:18 225:16 234:21 239:2,13 reducing [7] 127:5 131:14 152:18, 8
ran [1] 102:19 240:11 242:3 253:13 272:13 273: 19 236:4 255:8 256:3 relates [1] 166:13
randomize [1] 297:9 7 274:11 275:15 287:3 290:3 293: reduction [11] 58:12 59:15 116:2 relation [1] 22:11
randomized [6] 80:16 218:13 239: 14 294:16 296:11,19 304:13 305: 127:4 129:14 153:5 167:7,12 168: relationship [5] 163:20,22 164:9
13,14 297:12 298:5 18 311:12 312:13 19 237:12 238:20 172:21 264:4
range [4] 27:3 34:3 111:1 301:11 reason [17] 70:4 109:4 127:11 129: reductions [2] 150:21 236:3 relationships [5] 173:8,9 250:19
ranges [2] 26:12 141:11 2 151:19 172:18 197:21 199:2 reemerge [2] 144:4,12 263:14,17
ranging [1] 199:1 204:7 206:22 217:10 255:14 265: reemphasized [1] 54:21 relative [2] 48:15 309:5
rapid [12] 31:17 40:5 42:19 63:17 10 281:1 283:8 303:2 304:17 Reese [6] 2:3 3:6 5:9,9 6:11,14 relatively [10] 45:17 50:3 67:5 68:
70:8 159:22 183:17,19 209:6 264: reasonable [12] 120:14 129:12 referenced [1] 256:10 16 127:12 187:3 202:9,9 271:22
8 271:12 281:12 133:1 166:10 212:10 217:14 242: referred [2] 150:14 218:16 286:8
rapidity [1] 63:15 7 244:11 246:5 257:10 262:5 285: referring [3] 151:13 159:16 272: relearn [1] 190:8
rapidly [6] 46:19 112:15 187:8 277: 22 16 release [2] 183:16 283:5
22 278:10 284:8 reasoning [1] 119:4 refers [1] 116:19 released [1] 267:10
rare [2] 22:7 65:15 reasons [9] 35:16 125:20 146:11 reflect [1] 188:20 relevance [1] 51:16
rarely [1] 290:18 165:3 184:19 265:17,22 298:22 reflected [1] 95:5 relevant [7] 25:4 26:21 90:5 185:
rate [33] 27:22 30:12,15 43:10,17 300:3 reflex [2] 277:11 307:2 15 235:1 291:6 312:19
45:1 48:2 54:2,14,16 69:10 72:21 Rebitrone [1] 180:14 reframe [1] 198:1 reliance [1] 228:21
111:18 127:21 128:6 148:13,15 rebounds [2] 42:9 135:22 regard [8] 13:5,20 14:7 15:3,4 60: reluctance [1] 154:11
149:4 151:7 184:3 199:6,10 231:
Sheet 21 question - reluctance
reluctant [2] 223:12,13 residual [5] 66:10 128:19,20 145: responsiveness [4] 21:3 53:1 72: roof [3] 104:22 105:2,4
remain [8] 28:15 54:22 142:13 144: 3 161:22 13 262:6 Room [7] 1:10 4:16 8:3,6 84:14
11 175:19 190:4 191:13 193:8 resistance [41] 81:20 95:15,19 96: rest [2] 18:20 258:6 216:17 289:13
remained [1] 104:18 1 97:8,8,11 102:2,3,9,13,15,20 restrict [1] 265:10 rotating [1] 9:18
remains [5] 22:10 32:12,21 144:9 103:12,14 118:18 130:11 132:9 restricting [2] 240:4 268:3 roughly [1] 18:2
151:22 133:11,16 135:6 158:20 159:2 restrooms [1] 4:15 route [2] 112:3 254:16
Remarks [7] 3:2,7 4:2 9:11,13 108: 176:12 179:10 190:5,6 193:7 200: result [7] 10:21 29:13 30:7 33:9 42: routine [2] 24:5 137:6
5 137:14 3 209:7 220:15 236:5,7 239:22 13 54:11 85:9 routinely [1] 277:18
Remember [6] 27:22 74:21 145: 240:5,22 241:10,10 266:21 267: results [6] 29:14 42:16 55:8 134: rsistance [1] 105:20
21 164:19 237:21 267:4 11 308:2 16 291:18 312:19 rule [2] 45:21 71:13
remembered [2] 123:22 139:12 resistant [2] 103:19 242:15 resumption [1] 128:2 rules [7] 38:16 39:15,18,20 41:7,
remind [2] 11:22 243:7 resolution [3] 45:1 108:20 114:12 Retanovir [1] 266:18 10 70:18
reminiscent [1] 82:21 resolve [3] 44:22 45:3 169:2 retard [1] 81:20 run [3] 188:17 300:14 312:16
remission [1] 161:15 resource [1] 86:11 retarding [1] 154:1 running [1] 152:7
remodeling [1] 167:12 respect [10] 8:12 9:3 147:19 153:3 retesting [1] 141:14 RVR [5] 123:7,21 130:8 165:8 240:
removal [1] 253:1 203:21 204:20 217:11 228:10,18 retreated [3] 149:22 193:16,19 18
removed [2] 153:16 217:16 280:18 retreating [1] 192:2 RVR4 [5] 123:14 130:13 134:21
renal [5] 76:22 80:20 81:1 135:12 respectB-it [1] 231:5 retreatment [9] 118:1 134:8 143:4, 139:19 140:16
311:2 respectfully [1] 217:20 8,18 147:6 158:22 192:4 237:11 Ryan [2] 88:15 89:3
repeating [1] 126:2 resplendent [1] 59:19 retrospectively [2] 195:9 254:13
repetition [1] 109:2 respond [23] 29:5 37:2 38:19,20, return [1] 170:20
S
replace [1] 247:8 21 39:1,7 40:10,10 92:4 98:13,13 reversal [1] 128:20 SAE 82:1 83:2
[2]

replete [2] 135:17 165:18 147:4,8 157:9 178:6 183:2 199:9 reverse [1] 280:4 SAEs [1] 204:6
replicase 135:5
[1] 203:12 220:5 249:21 278:16 304: reversing 126:18
[1] safe [6] 50:21 83:4 154:6 163:12
replicate [2] 19:4 52:11 17 review [2] 15:10 25:2 229:5,13
replicating [1] 160:7 responded [6] 107:1 109:22 148: reviewing [1] 12:6 safely [2] 268:21 269:8

replication [19] 18:11,14,21 52:12 16,17 192:6 237:9 revolutionary 73:4
[1] safer [2] 209:4 249:1

ribavirin [48] 11:11,13 13:22 14:20 safety
[59] 24:9 80:14 91:8 93:1 96:
56:17 58:5 59:15 62:13 63:19 68: respondents [3] 107:13 109:22
6 110:9 144:11 153:5 154:6 161: 132:6 29:21 34:14 51:11 62:3,7,19 63:3 7,9,9,18,20 98:6 104:11 109:12
13,13,20 170:2 184:22 responder [3] 235:18,18 239:7 71:2,3,7 79:11 81:4,5,6,15 84:18 130:18 132:18 134:20 143:10 145:
Replicon [1] 176:11 responders [9] 42:19 116:20,21 91:22 100:12,12,16,22 103:4 104: 8 150:7,11 177:5 179:19 197:21
reported [2] 19:8 194:22 175:18 193:5 236:21 238:13 239: 5,21 115:22 116:9 118:2,9 132:4 198:2 205:22 206:2,5 210:7 212:
reports [3] 32:18 151:5 252:4 21 240:16 140:18 148:9 149:4,10 253:6 255: 13,21 214:3,8 224:13 225:10,22
represent [7] 8:17 107:6 117:4 responding [3] 150:1 153:14 168: 8,13,16,22 256:12,21 261:4 275: 226:12 228:5,11 232:18 233:2
198:15 232:15 304:20,22 13 18 287:14 291:13 246:22 249:14 263:18,20 264:1,1
representation [1] 13:17 response [127] 29:4 31:3 35:14 36: ribavirin-Bfour [1] 73:15 267:20 271:6,13 274:2,5 275:3
Representative [9] 2:9,11,17 8: 1 37:16 38:2 39:9 40:6 51:12 52: ribavirin=s [2] 81:1 132:6 285:22 288:10,16 290:11 292:9
13,15 16:12 84:16 138:10 309:11 17,18 53:12,13 55:9,12,13 57:15 ribosomal [1] 18:18 296:22 298:4 301:19
represented [2] 81:22 114:3 58:20 59:1,13 60:8,12,16 61:6 63: Richard [6] 2:7 5:11 7:19 229:10 sake [3] 91:17 227:3 235:19
represents [5] 18:18 20:12 107: 7,11,17,17,18 64:3 65:4,7,8,18 68: 257:5 303:3 salient [2] 108:6 310:8
13 183:19 184:1 7 69:7,10 70:9,10,13,14 71:5,12 rid [3] 231:3,10 298:21 salt [1] 107:11
request [3] 8:5 154:15 300:15 72:4,7,8,10,15 73:4 75:8,11 76:9 rigor [1] 156:6 salutary [1] 153:8
requesting [1] 186:11 98:17 101:7 111:18 112:17,22 rigorous [1] 218:14 salvage [1] 102:18
requests [1] 214:21 113:5,14 114:15 116:19 117:20 risk [43] 23:11,13 24:7,12 28:22 70: same [52] 17:3 28:16 30:12 33:8,
require [11] 96:16 193:16 226:7 120:18 123:17 125:1 139:18 143: 1 75:1,3 88:3 102:12 127:13 144: 17,20 69:20 71:14 80:17 92:1,2
238:14 245:10 247:6 264:21 265: 10,18 147:6 148:12,15 149:4 154: 16 146:9 150:12 166:18 167:13 95:14 104:20 112:22 115:22 122:
8 271:14 288:16 298:6 16 155:8 156:1 157:13 161:11 168:19 177:12,16 192:18 194:15 15 128:6 142:22 155:20 156:15
required [12] 73:17 96:4 150:21 162:3 163:17 164:7 174:21 175:3 195:4 200:13 201:15 210:13,20 157:6 158:22 163:8 164:17 175:4
166:17 171:18 235:11 258:20 272: 177:6 181:13,20,21 182:4,10,15, 211:1 216:15 219:21 220:2 232: 201:12 202:8 208:13 220:8 221:
5 284:16,22 301:13 302:21 16 184:3 187:13 191:19 192:1,4,5 15 235:7 236:5 240:22 241:7,9 15 230:19 232:5 249:15 251:3
requirement [5] 205:18 232:22 198:22 199:6,10 200:22 202:11 266:21 268:2 279:19 281:11 287: 252:17,18,20 253:2 255:12 262:3
260:9 297:1 303:21 227:8 231:16 235:15 236:15 237: 3 298:11 309:5 271:18 279:19,21 287:3 290:15
requirements [3] 245:1 288:8 10 238:9,10,18 240:13 247:10 River [1] 20:19 299:12,19 300:1,2,4 301:6,9
296:21 248:21,22 249:16 255:5 256:5 RNA [12] 18:8,17 19:8 26:8 40:18 sample [6] 42:21 121:9 303:9,15,
requires [1] 262:14 257:9 266:2 275:8 284:5 286:16 72:1 116:2 120:20 135:4 144:10 21 305:2
requiring [8] 82:12 193:18 206:12 291:12 294:1 297:5 302:20 308:7 175:19 282:14 samples [2] 34:15,16
226:12 245:14 246:16 272:14 302: 311:15 RNA-dependent [1] 19:8 sampling [13] 40:8 42:10,10,12
9 responseB-not [1] 202:9 RNAs [3] 25:10,12 136:12 122:6 125:21 138:11 139:17 156:
rescue [2] 78:22 204:6 Responses [26] 3:23 13:3 15:18 road [1] 297:6 6 164:13,15 166:6 210:5
RESEARCH [6] 1:3 5:18 6:19 96: 36:21 37:4 106:7,14,16 107:2,5 Robert [2] 2:9 49:20 San [1] 5:12
12 174:2 272:22 108:1 117:13 138:22 170:4,16 robust [7] 55:16 69:3 70:14 79:17 Santa [1] 123:2
researched [1] 234:17 175:4,5 181:16 182:10 185:2 187: 182:4 183:18 290:18 satisfied [7] 133:16 156:20 157:1
researchers [1] 105:16 15 188:15 203:19 243:3 307:20 role [7] 8:16 29:3 32:10 54:5 55:19 208:22 216:12 226:4 263:6
resemble [1] 106:21 308:4 69:7 185:17 save [1] 261:11
reserve [1] 115:1 responsible [1] 59:16 Ron [1] 5:6 saved [1] 261:8
reservoirs [1] 100:9 responsive [2] 57:3 69:15 Ronald [1] 2:12 saw [6] 36:20 52:20 54:13 127:18
140:22 169:10
Sheet 22 reluctant - saw
saying [21] 40:17 44:7 104:15,20 seeking [3] 12:3 77:13 250:12 182:20 291:7 174:10 227:5,17,18 229:11 238:8
107:3 121:22 127:19 177:20 199: seem [4] 29:2 128:4 240:16 285: several [6] 34:11 57:12 72:20 168: 248:21,22 256:15 264:6 302:12
21 209:12 225:3,16 254:8,14 271: 21 17 171:6 274:19 showed [10] 22:4 31:16 40:7 41:9
14 275:2 294:4 295:11 296:14 seems [12] 32:13 39:3 111:10 126: severe [7] 81:1 83:1 112:4 150:9 42:6 48:14 59:17 167:7 217:3 269:
302:15 305:5 19 212:10 230:1 250:16 256:8 151:18 286:14 300:7 6
says [3] 103:1 226:8 306:8 257:10,18 273:3 298:14 severely [1] 153:17 showing [6] 36:11 41:3 60:13 136:
saysB-the [1] 149:6 seen [16] 20:22 28:16 53:5 57:21 severity [8] 29:3 46:15 127:6 218: 14 252:13 288:10
Sc.D [1] 2:5 66:21 74:6 104:16 114:16 119:9 2 285:14 286:10 298:11,14 shown [26] 17:22 21:21 44:21 54:
scar [2] 47:6 67:1 137:5 151:22 241:17 271:20 272: sex [2] 24:10,10 12 55:2 59:9 60:9 62:19 65:6,12
scenario [2] 262:1 276:6 12 287:3 310:11 shame [1] 179:2 69:2,13,15 71:5,10 73:16 108:21
scheduled [1] 4:13 sees [2] 45:14 53:15 share [6] 105:10 139:21 157:2 209: 109:1 123:6 144:14 168:22 175:
schema [1] 20:2 segments [1] 51:22 19 230:11 271:22 14 184:8 254:12,13 286:15
scheme [1] 19:16 segregated [1] 74:22 sharply [1] 128:7 shows [8] 21:15 34:19 40:14 70:
Schering [4] 174:2,4 179:13 291: segue [1] 106:10 Shering [1] 3:28 12 146:5 181:19 229:13 275:7
15 select [3] 12:22 84:9 279:5 Sherman [177] 2:2 3:3,13 4:3 6:11 showsB-we [1] 146:2
Schiffman [1] 148:14 selected [2] 194:11 204:1 7:20 9:9,22 10:8 11:6 15:12 16:1, Shreveport [2] 5:7,8
School [1] 5:20 selection [4] 51:18 78:14 82:19 4,16 52:21 54:12 58:9 68:22 83: shunting [1] 204:22
schoolB-the [1] 290:19 242:14 15 84:6 106:3,6 142:6 143:17 147: shut [1] 31:8
science [1] 190:21 semi-normal [1] 47:1 9 150:6,11 151:20 153:2 155:4 sick [2] 150:18 189:19
scientific [2] 86:21 146:1 Senate [1] 89:5 156:7 157:8 158:1,9 159:3 160:15 side [13] 123:15 153:9 163:13 196:
scope [1] 12:13 senescent [1] 32:10 162:20 164:12 165:22 166:5 167: 1 200:2 203:20 209:8 213:12 222:
score [12] 79:20 125:6 129:8 146: sense [20] 41:4 75:14 90:9 98:21 20 168:12 169:13 171:1,16 174: 1 255:15 290:15,20,20
7,8 204:9,11 278:22 279:2,3,7 145:9 160:4 162:8 165:9,21 166:9 11 180:2,4 183:7 186:10,15 190: sign [2] 172:4 173:17
280:4 178:5 221:9 234:18 238:6 245:9 16 196:17 198:7,18 202:12,15,21 signal [2] 25:11 305:20
scores [2] 145:21 225:6 256:13 257:3 267:16 268:20 270: 203:6,14 205:5,9 206:17 207:15 signaling [2] 59:13 72:13
scoring [1] 128:13 1 208:7,17,19 209:18 211:3,12,20 signature [1] 56:10
screen [2] 53:10 76:18 sensitive [7] 25:9 34:22 86:17 212:15 213:11 215:9,11 216:6,16 signed [4] 171:7,20 173:18 186:11
screened [2] 7:11 23:12 112:12 124:10 144:22 192:22 217:3 218:5 219:17 221:19 223: significance [1] 21:1
screening [6] 23:21 24:5,6 25:6 sensitivities [1] 41:22 20 225:12 226:16 227:22 229:8, significant [10] 17:17 22:9 33:10
26:16 53:18 sensitivity [1] 25:7 20 230:17 232:7 234:9,20 236:16 67:4 71:10,11 129:6 147:16,22
se [1] 160:6 sent [1] 12:16 237:1 238:2 239:9,17 240:9 241:3 238:19
seats [1] 258:1 separate [12] 87:17 112:11 192:19 242:8 243:7,22 245:12,22 246:14 significantly [2] 34:6 169:22
Seattle [1] 4:21 212:21 213:6 224:8 237:1 249:7 247:1 248:1,9,16 249:8 250:6,9, signs [2] 48:2 229:11
second [21] 32:17 33:15 35:10 45: 279:12 280:22 302:21 306:11 15 251:9,12 252:15,19 253:12 silence [1] 127:9
12 54:12 58:6 76:10 79:18 107:10 separated [2] 237:19 302:21 255:1,20 256:7 257:4,9 258:5 260: silent [1] 127:11
150:6 158:18 163:18 183:22 184: separately [3] 192:4 225:8 258:18 14 261:17 262:17 263:10 265:2, Silver [1] 1:11
12 193:21 198:20 202:13 230:8 separation [1] 303:2 12,16 266:6 267:3 268:1,6 269:11, similar [13] 14:16 28:16 37:1 41:1,
274:14 279:15 283:12 seque [1] 305:17 21 270:1,6,8,22 271:4,10,18 273:3, 4 78:8 80:18 81:8 83:10 161:5
second-string [1] 200:9 sequence [3] 19:16 25:15 212:3 18 276:22 278:5,18 281:5 283:2 186:6 256:1 270:8
secondary [7] 82:8 120:14 125:16, sequential [1] 169:15 284:4 285:11 288:2,7,11 291:12, similarly [5] 25:12 26:11 37:3 276:
19 126:21 140:3 166:20 serial [1] 102:6 18 292:3,15 298:8 300:11,19 301: 22 290:21
section [1] 196:18 series [5] 67:11 168:14 197:2 203: 16 302:18 303:16 304:5,8 305:9, simple [2] 164:17 238:11
see [81] 4:18 17:16 18:2 19:11 20: 1 254:2 16 306:6 307:14 308:5,22 310:6, simplified [1] 28:8
15,19 25:19 26:4 31:5,17 33:6,19 serious [9] 76:20 88:4 145:11 167: 20 311:14 312:21 simplifying [1] 235:19
34:16 37:22 42:16 47:18 48:16 50: 13 175:1 199:16,17 200:14 230: Sherman=s [5] 57:22 58:14 83:8 simplistic [1] 218:11
18 53:10,20 54:1,19 58:6 61:1 71: 20 161:17 180:19 simply [6] 30:8 39:6 154:16 165:
11,19,22 73:18,19 106:13 108:1, seriously [5] 88:8 91:5 92:12 214: shooting [1] 104:3 16 176:10 255:13
15 110:5 115:8,19 131:1 137:11 1 231:19 shopping [1] 206:19 simulate [1] 59:11
142:10 148:18 153:13 155:2 168: serotype [1] 18:11 short [17] 37:18 38:12 40:11 45:18 simultaneous [1] 244:13
9 172:8 176:12 183:17 184:11 serum [6] 32:6 58:4 61:16 63:13 50:3 67:5 68:16 96:18 107:20 119: simultaneously [4] 45:15 187:18
197:5,19 202:5,10 204:1 206:5 129:14 183:11 13 135:9 160:18 161:4 166:6 205: 278:7 300:14
208:11 209:8 210:4 213:9,10 214: serve [3] 13:22 17:1 18:22 2 240:18 282:17 since [17] 16:5 51:12 79:7 85:15
12 216:2,17 218:12 224:15 227: served [2] 180:13 186:19 short-term [2] 79:21 243:2 113:2 143:11 155:18 159:1 163:
11 228:3,15 232:3,4 254:8 255:10, Service [1] 9:20 shorten [3] 184:16 252:10,12 22 174:5 191:5 198:4 220:22 246:
21 260:9 266:10 270:2 279:10 SERVICES [1] 1:1 shortened [2] 229:7 255:3 8 247:10 256:14 271:14
285:18 286:5 290:21 291:3 305: SESSION [3] 1:5 172:15 227:3 shortening [2] 251:19 252:11 single [7] 51:14 179:9 202:17 242:
19 312:9,22 set [13] 31:15 55:9 56:9 84:6 94:10 shorter [9] 14:17 131:12,14 139:7, 13 257:14 275:17 281:13
Seef [46] 2:18 5:17,17 147:8,10 104:9 105:19 147:10 154:9 204: 9 157:21 168:22 169:4 264:7 single-agent [4] 179:6 209:9 235:
152:1 167:3,20,22 198:7,8,20 202: 13 242:6 287:6 290:3 shortest [1] 163:14 6 238:16
14,19,22 203:10 219:17,18 222:15 sets [2] 68:19 251:22 shot [6] 104:22 105:2,4 119:6,7 single-arm [1] 239:14
223:5,18 230:17,18 233:16,18 setting [16] 41:8 50:6 150:20 160: 139:16 single-stranded [1] 18:8
237:2,3 239:17,18 247:7 248:7 19 165:15 166:9 169:10 183:3,4,9 shouldn=t [7] 248:11 257:1 270: sirolomus [1] 278:1
255:1,2 256:2 273:14 283:3,4 284: 186:6 206:11 210:6 267:12 276: 12 281:22 304:2 309:17 312:2 sit [1] 186:20
14,22 293:20 295:19,22 297:7 18 277:19 show [27] 10:15 11:22 26:20 34:9, site [2] 18:18 144:11
306:6,7 310:14 settings [1] 161:1 19 35:10 46:22 60:9 66:6,9 68:17 sites [1] 57:13
seeing [2] 135:22 150:19 seven [6] 26:7 148:4 175:17 176:2 72:11 73:7 89:20 120:17 165:1 sitting [2] 95:7 214:2

Sheet 23 saying - sitting
situation [5] 31:13 87:13 88:6 214: somebody [4] 218:7 219:11 239: sponsors [5] 7:9 12:4 95:21 155: 14 79:2 97:20 113:12 208:14 245:
19 219:9 12 240:17 22 306:2 19 280:9 304:1
situations [1] 137:6 somehow [4] 199:2 230:19 237: spontaneous [3] 53:11 108:20 statistical [1] 156:10
six [15] 20:2 26:14 27:7 42:21 54: 14 272:2 286:17 statistically [3] 71:10,11 245:16
14 84:15 87:1,8 92:14 108:2 110: someone [9] 146:19 197:15,21 spontaneously [2] 55:17 56:22 statistician [2] 5:20 213:1
10 149:5 175:18 187:3 252:20 212:5,6 221:10 240:21 248:10,13 Spot [1] 181:19 statistics [1] 155:17
size [4] 218:7 303:9,21 305:2 sometimes [2] 42:20 156:2 Spring [1] 1:11 status [1] 153:15
sizes [2] 213:8 303:15 somewhat [5] 42:3 107:12 116:17 spur [1] 191:7 staunch [1] 112:10
skepticism [1] 230:11 119:10 155:18 squirming [1] 258:1 STDs [1] 24:9
skews [1] 60:15 somewhere [1] 199:10 stability [1] 27:7 steady [9] 24:10 28:19,21 29:10,
skip [1] 112:7 soon [8] 103:20 139:15 207:3 220: stable [1] 189:9 14,16,16 30:1 43:13
slap [1] 240:1 17 221:14 228:5 229:3 231:20 STAFF [2] 2:21 9:8 steatosis [1] 46:5
sleep.@ [1] 49:22 sooner [1] 299:4 stage [21] 50:6 54:4 67:3,13 69:9 steeper [1] 36:11
Slide [165] 10:14 11:3,8,21,22 12: sophisticated [1] 62:1 101:14 111:7 113:9 125:5 154:9 stellate [1] 53:2
12 13:4,19 14:6,8 15:2,9 16:17 17: sorry [2] 107:18 202:15 167:5,11,11,12,12 197:8 202:16 stems [1] 12:15
5,14,20 18:6,15 19:3,18 20:14 21: sort [12] 32:21 39:16 59:21 104:2 203:15 211:21 243:4 268:9 step [3] 17:12 95:3 207:19
5,13 22:2,3,15 23:10 24:3,21 25: 106:10 137:4 163:7 209:2 215:1 stages [9] 32:13 45:10 47:14 69:9 stepped [1] 177:20
16 26:18 27:13 28:11 29:8,18 30: 252:7 266:19,22 153:19 189:1 203:17 214:10 246: steps [1] 50:18
3,18 31:11 33:1 35:3,15 36:2,7,15 soul [2] 119:19 129:13 10 Stewart [1] 26:19
37:17 38:4,14 40:13,22 41:6 43:5 soul=s [1] 127:21 staggering [1] 158:6 still [30] 17:11 24:12 27:17 44:13
44:18,20 45:19 46:9,20 47:22 48: sounded [1] 156:20 stain [1] 47:4 49:21 55:14 58:16,18 62:17 63:21
8,20 49:3,9,18 50:16 51:6 52:6 53: sounds [1] 225:15 stalking [1] 144:7 66:1 73:18 78:11 88:22 102:17
8,9 54:10,13 55:6,18 57:4,11,20, source [1] 121:10 stance [2] 210:14 262:19 124:19 145:3,4 147:12 167:14
21 58:2 59:2,17,18 60:4,20 61:7, sources [2] 88:19 258:9 stand [2] 92:18 93:20 231:13 243:19 266:3,5 275:2 292:
22 62:6,18 63:8 64:17 66:4,16 68: Southeast [1] 20:18 standard [77] 11:12,14,17 13:21 22 293:11 299:19 301:12 303:7
20 70:6,7,19 71:16 72:18 73:12 Southern [2] 190:17 191:3 14:11 36:5 40:2 51:12 59:6 64:5 stimulates [1] 60:13
74:1,9,16 75:13 77:2 78:1,9,19 80: Southwest [1] 204:10 70:5 73:14 75:9 76:3 77:8 85:19 stimulatory [1] 60:11
8,19 81:9 82:14 83:8 84:2,10 86:3 speaker [5] 83:16 172:6,19 180:3 86:1 94:13 101:13 103:3,7 109:7 stop [10] 40:21 41:14 64:2 131:1
88:15 89:13 90:17 96:5 98:8 99: 190:16 111:17 113:3 118:11 129:21 130: 179:1,5 213:10 220:7 295:16 296:
10,13 100:3 102:1,22 103:1,22 speakers [3] 142:12 173:18 191: 20 131:4,11,21 132:2,15 134:7,8, 8
105:21 106:12 107:16 108:8 109: 15 18 139:4 140:15,21 143:2,7,10,15 stopped [3] 30:4 32:4 76:7
6,20 110:2 111:5 113:4 114:5,17 speaking [5] 4:8 52:1 95:6 173:11 147:6 148:22 149:3,21 156:18 stopping [7] 37:22 38:16 70:18
115:11 116:11 118:4,22 119:22 286:8 157:2 166:16 169:10 189:14 201: 156:22 157:2 162:10 166:21
120:16 122:18 124:15 125:15,22 speaks [1] 164:2 18 203:18 207:22 209:11,13 240: stops [1] 121:8
127:8 128:11 129:17 131:9,17 special [19] 7:18 52:14 75:12 76: 19 242:2 252:11,20 253:5 262:7 story [2] 116:14 247:10
132:3 133:5,8 134:3 135:1,13 136: 13 78:10 135:11 141:5,15 195:6 264:17 269:7 275:5,9,12,13,16 STR [1] 74:11
22 137:13 138:13 139:10 140:12 222:6 226:1 229:11 230:3 263:21 276:19 278:16 287:8,11,12,13,16 straight [2] 4:15 33:12
141:8,9 156:17 174:11 270:20 276:13 284:20 289:4 297: 292:22 straightforward [3] 126:20 157:
slide-Bwe [1] 145:20 4 standards [2] 189:18 217:16 11 222:10
slides [5] 21:15 52:20 66:21 92:13 species [1] 19:12 standpoint [5] 66:6 236:7 242:10 strain-specific [1] 251:7
94:13 Specific [27] 8:1 29:22 48:21 56:5 252:3,8 strand [1] 18:8
slightly [1] 23:7 59:22 60:2 159:13 161:1 171:8 stands [1] 232:8 strata [8] 201:3 302:8,8,9,12,13,14,
slope [10] 31:22 32:11 33:15 36:12 182:12 188:1 196:19 204:3 207: star [1] 57:13 16
58:4,6,7,11 164:17 184:15 16 229:14 233:7 240:10 243:8 stark [1] 182:9 strategies [6] 109:18 163:6 174:
slow [2] 27:11 263:5 246:19 247:4 251:11 252:9 257: start [30] 4:19 17:6 33:4 44:5 79: 15 257:7,16 282:21
slower [1] 124:9 10 258:14 275:6 304:5 311:22 10 97:4,6,11 110:4 136:14 142:9, strategize [1] 145:12
slowing [1] 126:17 Specifically [9] 13:5 181:11 188:9 14,18 158:6,7 173:19 180:21 186: strategy [3] 145:14 153:7 206:11
slowly [2] 46:1 286:9 207:21 248:17 250:18 272:11 284: 12 195:22 196:9,21 197:7 203:8 stratification [6] 265:8 266:2,12
small [11] 20:10 29:22 42:9 65:12 18 306:13 212:4 214:11 233:18 251:4 258: 267:15 303:8 307:16
84:14 153:22 160:18 241:12 246: specifications [1] 111:4 16,21 261:20 stratifications [1] 311:21
16 296:22 300:4 specificity [2] 25:7 125:20 started [5] 85:2 92:11,12 106:6 stratified [4] 76:1 213:2,6 237:15
smaller [6] 225:22 226:7 263:18 specifics [1] 159:17 233:8 stratify [3] 75:19 201:19 246:11
264:5,22 288:17 specified [1] 133:13 starting [7] 16:7 31:16 33:8,19 stratum [2] 265:8 268:3
smallerB-the [1] 222:1 specimens [2] 67:10,11 110:4 169:20 193:2 stream [1] 57:1
sNDA [1] 180:14 spectrum [3] 111:21 147:20 275:4 starts [3] 45:12 54:11 121:9 street [2] 158:20 213:13
so-called [2] 134:1 235:17 speculate [1] 158:11 STAT [1] 59:12 stress [1] 261:1
societal [4] 48:18 49:6,16 276:10 speculating [1] 159:8 state [23] 28:19,21 29:10,14,16,17 strict [1] 41:12
society [1] 16:20 speculation [2] 91:17 161:8 30:2 43:14 53:6,14,19 80:4 144:5 strong [3] 78:15 232:21 301:17
socioeconomic [1] 194:16 speed [1] 298:6 151:9 162:5 173:19 219:4,7,12 strongly [9] 80:13 87:14 91:2 179:
softer [1] 99:19 spell [1] 173:13 274:6 279:8 282:17 283:17 14 187:16 188:12 196:22 229:2
sold [1] 234:18 spend [1] 112:19 stated [5] 199:10 216:20 259:1 244:12
sole [2] 26:16 253:19 spent [1] 84:15 262:19 281:15 structural [3] 18:19 55:10 61:1
solely [4] 61:4 71:1 159:17 161:19 spinning [1] 193:10 Statement [13] 3:5 6:12,13 9:7 structure [1] 25:14
solicit [1] 118:3 spirit [2] 161:7 180:6 171:18 172:10,20 173:6,10,15 structure-function [1] 250:19
solid [1] 136:21 spoke [1] 198:22 194:7 211:5 269:5 struggling [1] 219:18
someB-again [1] 119:14 spoken [2] 106:1 127:10 States [12] 17:16,22 20:18 22:8 74: stubborn [2] 183:21 184:12

Sheet 24 situation - stubborn
studied [17] 12:19 111:11,15 115: submitted [1] 107:14 supportable [1] 253:7 T-alpha-2 [1] 56:8
8 137:22 157:21 169:14 197:11 submitting [1] 8:5 supported [1] 129:11 T-cell [1] 181:20
206:2 211:16 220:9 225:18 242:1 suboptimal [1] 179:8 supportive [1] 270:16 T-helper [3] 55:12,20 56:2
264:21 277:17 281:1 311:8 subpopulation [1] 72:21 supportiveB-very [1] 270:16 T-helper-1 [4] 56:11 60:8,16 62:
studies [160] 12:20 23:4 27:9 32: subpopulations [4] 87:20 88:9 suppose [4] 159:7 163:2 209:12 22
20 37:4 47:11 51:10 66:9,12 72:9, 263:19 298:1 210:9 T-helper-2 [1] 63:2
17 73:7,14,15 92:12,17,19 94:5,12 subsequent [1] 144:17 suppresion [1] 125:12 T-lymphocyte [1] 57:7
96:8,9,10,10,11,13,16,17 97:5,16 subsequently [3] 152:21 168:20 suppress [3] 124:17,18 161:12 T-regulatory [1] 56:4
103:10,12,16 105:17,18 114:14 170:21 suppressed [1] 162:11 t.i.d [1] 266:20
128:9 131:21 133:11,17 134:13 subset [4] 45:6 72:9 179:3 227:9 suppresses [1] 272:2 table [3] 8:3 84:6 310:22
137:8 141:20 153:4 157:4 158:5,7 substance [2] 99:3,4 suppression [10] 120:11 124:16 take-Beven [1] 249:14
167:14 168:8,14,17 175:16 177: substantial [2] 138:15 304:20 137:7 140:5,6 141:20 150:12 162: takeB-if [1] 231:9
16,21 178:18 187:19 194:10 195: substantiated [1] 129:11 14 175:12 196:5 Talal [1] 42:5
1 197:10,17 199:8 200:9 203:1,22 substitutes [2] 79:14 81:4 surely [1] 283:15 talked [8] 66:5 68:21 175:7 177:13
204:1,13 206:9,12 207:17,20 209: substituting [3] 132:10 254:1 255: surprised [1] 312:9 178:1 235:16 241:7 274:1
17 213:6,7 216:1,3,18 217:20 218: 9 surprising [1] 183:17 talks [2] 88:13 190:20
14 220:7,10,19 222:2,13,22 226:8 substitution [7] 14:20 132:4 140: surrogate [4] 53:19 61:15 120:7 target [8] 25:11 55:5 225:20 282:2,
227:10,12 229:17 230:3,13 231:1 18 253:10,14 256:16 257:7 121:3 19 283:1 303:15 311:17
232:5 233:3,5,8 237:17 241:18 substitutions [1] 275:18 surrogate-Bit [1] 53:18 targeted [4] 213:8 250:21 257:12
243:2 248:19 253:10,11,14 254:6, substudies [3] 193:6 195:16 270: surrogately [1] 70:4 263:2
15 256:9,11,17,17 257:19,20 260: 19 surrounded [1] 47:5 targeting [1] 184:9
16 261:6,14,20,21 262:16 264:5, substudy [1] 213:8 surrounding [2] 186:7 190:11 targets [3] 19:1 250:20 276:16
22 267:18 268:9,10 270:10,19 subtract [2] 253:5,6 survey [1] 154:15 targetsB-to [1] 196:7
272:5 273:4 274:3 277:2 278:6 subtype [1] 20:13 survival [6] 72:21 80:2 126:12 146: task [4] 90:8 92:16 106:10 196:10
281:14 283:7,14,16 284:11 285:1 subvert [1] 61:3 4,6 153:21 tAttAt [1] 85:12
289:16 291:15 295:16,21 296:12, succeed [1] 217:8 survive [1] 188:7 tattooing [1] 24:19
15 297:3,4 299:1,3,13 301:18 302: success [5] 83:10,12 119:6 125: suspect [5] 151:9 159:10 169:3 tau-like [1] 12:10
22,22 303:10,11 304:21 305:21 13 262:5 199:21 302:2 Tauber [17] 2:24 3:24 6:5,5 13:2
306:1,3,12 307:18,22 308:9,9,14, successful [4] 141:2 229:19 279: suspected [1] 36:20 15:17 106:9 144:1 145:19 150:11
14 20 282:21 sustained [18] 37:16 51:12 58:19 154:9,14 155:5,16 156:15 178:10
studies= [1] 261:1 successfully [1] 312:16 63:11 64:3 101:6 117:19 120:18 198:22
studies@ [1] 296:18 sudden [1] 308:16 160:1,2,9 161:11,14,15 175:15,18 Tauber=s [1] 181:3
studiesB-I [1] 265:9 sufficient [9] 65:22 137:20 213:9 227:8 238:18 teams [1] 180:13
study [109] 7:4 14:4 22:19 46:10 269:12 303:21 305:2,14 308:19, SVR [70] 11:15 39:13 62:5 64:6,18 technique [2] 67:17,20
51:17 69:19 71:22 75:17 77:4 84: 20 65:22 69:2,3 70:15 71:5,19 73:19 techniques [1] 145:1
20 88:7 98:9,15 100:1 101:20 105: suggest [11] 22:13 27:10 83:11 97: 77:20,22 80:3 101:21 104:2 118:1 technology [4] 117:9 120:8 123:9
7,11,12 111:6 115:1 127:17,18,19 5,7 103:11 104:7 105:7 129:13 120:10,18 121:2,10,16,17,21 122: 135:18
128:4 129:18,20 144:13 145:15 144:13 269:9 1,5,10,14,20,21 123:2,14,16,21 teeth [1] 226:10
147:12 148:3,4 149:6,7,17 150:13, suggested [14] 43:11 97:13 114: 127:16,21 128:1,4,5,8,12 135:15, tempered [1] 205:19
14,18 152:2,6,8,12,21 154:13 167: 13 123:6,12 125:10 132:21 141: 17 136:20 137:2 139:11,11,11 temporary [1] 277:13
9,18,22 180:11 187:7,17,21 188:6, 22 156:17 170:3 226:4 236:5 238: 141:9,13,17 143:22 144:20 147:1 temptation [1] 78:6
9,19 189:10 200:21 204:16,18 16 262:14 156:21 158:12,13 159:10,11 160: ten [4] 85:18 101:9 141:12 172:1
208:5,22 209:1,9 211:9,18,18 212: suggesting [11] 22:17 36:13 37:2 12 161:19 165:11,13,15,18 184:4 ten-fold [1] 54:2
7 213:2 214:5 215:6,15 216:2 217: 49:13 221:1 241:6 265:12 269:11 195:11 253:3 279:9 tend [5] 98:21 175:21 176:12 187:
19 218:19 225:9,20 227:5 228:3,7 270:2,18 293:22 SVR12 [1] 15:6 13 286:13
236:8 239:13,14 241:5,14 248:14 suggestion [1] 192:16 SVRs [2] 64:15 143:1 tendency [1] 267:6
251:1 253:8 255:11 264:4,8,16 suggestions [2] 40:6 130:7 swallow [1] 291:8 tends [2] 21:19 187:8
265:11 266:5 267:17 274:9 276: suggests [5] 18:9 19:5 58:21 133: Swan [20] 2:17 5:4,4 197:15,16 tenofovir [2] 272:10,17
15 278:2,15 280:22 291:16 293:2 19 245:5 211:13 212:2 234:10 240:9,10 term [4] 80:3 163:1 222:2 293:15
294:22,22 295:2 296:3 305:4 307: sum [3] 257:9 301:16 302:6 259:5 260:14,15 266:6,7 271:10, terminate [4] 68:5 161:10,13,19
4 308:16 310:7,10 311:19 summarize [5] 13:2 15:18 108:5 11 305:9,17 312:7 terminated [1] 167:22
studying [2] 140:14 205:2 197:6 232:7 swinging [1] 163:7 terminates [1] 63:19
stuff [1] 34:8 summarized [1] 275:1 switch [1] 163:10 terminating [1] 51:1
sub-specialists [1] 289:20 summarizing [1] 51:8 switching [1] 56:8 termination [6] 58:5 59:15 79:18
subcutaneously [1] 291:11 Summary [5] 3:23 106:7,14 108:1 sympathetic [1] 217:15 154:6 162:15 170:16
subgroup [7] 81:3 193:19 259:12, 181:3 symptoms [2] 25:21 48:2 terminology [1] 28:12
20 289:7 294:15 295:14 summation [1] 268:7 synergistic [1] 132:19 terms [45] 17:8,9 23:21 40:10 41:
subgroups [17] 11:18 13:18 23:4 Sun [7] 2:10 5:22,22 8:14,19 218:5, synthesis [1] 62:11 12,20 46:6 48:12,17 64:13 66:2
197:2 246:13 269:19 284:7,20 6 synthesize [1] 105:3 73:19 79:14 86:16 96:17 97:14 99:
288:17,19,20 289:4 294:8,11,13 Sun=s [2] 8:16 246:2 synthetic [3] 79:22 110:21 204:20 11,14,17,17 104:1,5 112:2 139:4
295:13 308:1 superb [1] 228:10 syphilis [1] 82:22 143:13,22 144:13 145:15 156:10
subject [6] 14:15 55:21 77:15 94:4 superior [1] 262:6 system [7] 4:9 60:6,7 176:11 183: 162:4 166:17 168:22 191:19 194:
157:10 228:8 superiority [4] 79:6 238:8 252:5 1 227:16 228:21 4 228:5 251:19 252:1 253:2,3,15
subjecting [1] 240:21 257:8 systems [2] 67:2 128:13 267:8,16 275:3 279:12 308:18
subjects [3] 13:10 16:22 272:12 support [7] 88:17 129:16 135:9 terrible [2] 231:4 288:21
submit [3] 191:10 217:18 218:21 179:14 207:17 226:17 249:10
T terribly [3] 55:1 220:22 241:15
T-alpha-1 [1] 56:7
Sheet 25 studied - terribly
terrific [2] 231:8,18 65:21 66:14 75:20 76:12 85:1,20 104:6 228:11 3,10 139:6,7,8 140:15,16,18 141:
test [6] 25:6 41:22 54:8 70:11 132: 86:1,4 101:6 103:2 104:1 125:3 tract [1] 67:19 10,18 144:21 148:12,16 149:9,12,
19 181:19 130:19,22 136:13 141:14 160:10 tracts [1] 67:13 13 152:14 153:11 155:9,10,20
tested [3] 38:12 44:12 151:22 167:4,6 175:22 236:3 237:19 241: Tracy [14] 5:4 197:15 199:21 211: 158:6 160:22 161:14 162:7 165:5
testing [5] 24:14 26:4 163:15 193: 12 292:11,11 303:20,22 304:1 12 234:9 240:9 260:14 261:19 166:21 168:4 169:4 174:6,9 175:
1 247:3 305:4 307:16 262:14 266:6 271:10 305:9,16 18 182:2,7 183:10,18 184:3,16
tests [8] 24:22 25:2,6 26:6 54:7 threshold [1] 129:9 312:5 191:14,14,20 193:1,3 194:3 196:
101:15,19,22 threw [1] 164:22 tradeoff [1] 218:17 14 200:11,22 201:18 207:11 210:
Texas [1] 16:15 through-BI [1] 301:21 tradeoffs [1] 218:15 20 232:17 233:5,22 234:2 235:9
text [1] 86:18 throughout [1] 202:7 traditional [1] 159:11 236:1 240:16 242:20 243:13 255:
Th1 [1] 56:21 throw [3] 158:10 227:4 272:14 traditionally [1] 222:22 3 259:3 262:4 263:15 264:5 267:9
Thanks [2] 83:22 261:16 Thursday [1] 1:7 traffic [2] 86:11,15 268:4,15 272:12 273:15 279:18
that=s [1] 37:7 tied [1] 39:2 trajectory [2] 218:3 280:5 280:14 287:11,20 292:6 293:1,6,8
theme [1] 122:9 tight [1] 41:20 transiently [1] 26:10 297:10 303:13
themes [1] 118:17 till [3] 88:20 154:13 270:13 translate [3] 136:3 165:5 279:15 treatment-experience [1] 233:
themselves [3] 58:12 100:11 287: timely [3] 96:14 205:17 300:10 transparency [1] 172:14 10
7 timing [4] 15:6 68:2 121:17 139:14 transparent [1] 172:12 treatment-experienced [23] 14:
theoretically [1] 33:9 tired [1] 176:3 transplant [71] 21:12 45:17 71:15 15 75:6 76:4 78:2 111:13 113:17
theory [1] 63:22 tissue [2] 63:1 67:19 74:4 80:11 88:12 93:5 109:4 115: 119:1,8 123:1,4,15,19 138:4 177:
Therapeutic [8] 3:15 50:13,19 51: tissues [2] 18:14 52:12 9 126:16,22 127:6 128:3,22 129:2 9 178:2 179:21 234:3,7 236:16
18 55:21 181:12 182:18 278:11 title [2] 106:13,15 136:16 146:1,10 150:20 152:19 241:15 244:5,17 280:20
therapeutically [1] 56:19 to.@ [1] 270:15 160:19,22 195:5 210:6,8 216:21 treatment-expreienced [1] 130:
therapies [28] 40:3 69:16 70:20 today [29] 12:1,6,14 15:19,21 17:2 217:6,17 218:1 219:21 220:19 8
77:13 82:20 150:8 175:9,14 178:4 47:13 84:1,4,5 85:22 89:14 90:5 221:11,17,18 225:6 228:19 258: treatment-naive [14] 74:21 75:16
180:21 181:2,10 182:21 183:6,7 92:11,18 95:6 97:17 99:3,8 106: 10 273:10 274:4,4,7,7,13,14,16,20 111:14 113:9 119:5 122:22 123:5,
184:6,21 185:1,9,10 186:8 207:7, 22 107:3,6 180:18 181:5 187:7 275:9,11,21 276:5,8,13,17,19 277: 18 125:17 130:4 138:1 177:8 269:
13 209:14 214:17 217:19 254:3 188:18 195:19 257:1 309:4 19 278:9 279:10,14,18 280:13,14, 6 270:18
266:11 today=s [5] 7:8,21 8:3 9:16 15:11 21 281:9,11,21 282:8 284:6,10,11, treatment-race [1] 303:5
therapy [102] 14:2,2 29:4 34:18 37: together [4] 35:21 105:10 112:16 19 296:3 treatmentB [1] 294:20
3 39:12,14 51:13 57:1 58:2 63:9, 241:13 transplant-free [1] 80:2 treatments [18] 113:1 117:17 122:
20 64:2,5,16 65:3,4,13,20 68:10, tolerability [6] 81:16 251:14,18,19 transplantation [23] 6:4 11:1 13: 11,13 131:6 135:3,16 138:17 139:
17,17 70:5,10,11,18 71:9 73:3,6 252:1,7 13 76:17 78:21 111:22 126:11,19 13 151:3 153:1 184:14,18 232:16
76:8 79:1 81:22 82:19 83:5 93:17 tolerance [2] 175:5 275:13 127:2 128:18 146:6 152:9,16 204: 244:9 249:11 261:10 272:10
98:17 100:15 102:18 109:11,12 tolerate [2] 70:21 150:20 3,7 222:19 225:7 228:21 273:6,10, tree [3] 19:19,22 166:12
116:8 143:13 145:2 151:1 153:14, tolerated [5] 73:22 119:2 174:22 16,19 280:9 trees [1] 19:20
17 159:10,13,14 160:2,9 161:2,10 290:17,22 transplanted [5] 74:12 127:4 146: tremendous [2] 92:16 185:3
166:14,16,16 168:18,22 169:15 tolerating [1] 290:18 5 204:15 274:22 trespass [1] 154:20
170:22 176:9,17 177:11 179:6,8 Tom [1] 297:8 transplanters [1] 129:3 tri-infected [1] 187:1
180:8 182:14 183:12 186:1 192:1, tomorrow [3] 15:21 312:4,22 transplants [5] 74:14 213:20,22 Trial [67] 3:14 6:20 12:18,21 14:7,
20 196:1,9 205:3 208:3 212:4 213: tomorrow=s [1] 15:11 217:2 231:22 10 15:15 41:3,14 50:9,12 51:20
16 214:11 217:9 235:7 238:17 tonight [1] 237:21 travel [1] 173:3 70:17 77:16,18,21 78:6 106:18
240:3 252:22 253:18 259:11,13, took [3] 128:8 224:19 239:2 traveled [1] 87:2 139:1 147:13,13,15 149:9 152:7,
15,17,18,20 260:2,7 262:6 267:21 tool [2] 67:8 182:18 Treat [27] 3:15 39:6,6 50:13 73:16 13 167:1 176:11 185:14 186:14
275:9,11,14 276:16 279:20 280: tools [5] 44:9 123:22 139:19,20 83:7 111:20 112:13,16 130:22 192:19 211:16 220:21 221:21 223:
10 282:5,18 140:1 134:2 143:14,14 145:10 157:18 15 224:6,8,10,21 225:3,11 237:6
thereafter [1] 228:6 top [5] 75:6 76:15 110:12 207:22 174:14,17 220:22 222:11 242:5 250:4 253:19 254:7,18 259:19,20
thereby [2] 184:13 242:6 261:4 249:18 262:10 283:8,19 295:7 260:8 262:2,3 263:4 267:20 268:5
Therefore [17] 35:12 53:6 61:15 topic [6] 7:8,12 9:16 10:13 173:1 296:10 298:16 269:6 278:11 281:4 282:19 289:
133:10 138:2 146:9 188:8 189:6 294:12 treated [34] 26:22 34:14 36:5 41: 19 291:17 292:7 297:17 302:13
199:5 207:7 215:13 217:19 219:2 topics [1] 7:13 13 64:9 115:20 148:1,7,11,12 153: 309:8 310:8,14,18 311:4
265:20 279:17 289:18 306:20 total [6] 24:13 31:7 120:10 172:6 19 178:15,21,22 199:13,22 200:6 trials [63] 11:14 13:1 39:17 40:14
thinking [7] 92:10 214:3 215:5 237:12 283:4 201:17 203:13 212:22 220:16 221: 51:14,17,19 60:2 64:14 65:16 73:
253:13,15 258:22 307:2 totally [1] 162:21 1 223:12 231:7 237:8 239:21 240: 20 77:12 79:6 80:16 81:12 114:8,
third [7] 26:7 32:19 130:2 132:1 touched [2] 98:10 112:18 8 259:14 268:21 269:8 287:17,18 13 135:3 138:12 146:21 157:16
140:14 199:3 279:14 tough [1] 251:17 292:17 295:1 167:4,6 174:5 179:15 185:11 186:
this-Bthat [1] 146:3 tougher [1] 73:16 treating [10] 47:14 76:14 81:19 17 191:4 192:15 194:13 212:10
thisB-12-week [1] 40:1 toward [1] 81:12 140:17 151:2 192:12 220:18 243: 218:13 222:8 227:7,9 232:14,20,
though [14] 11:16 25:2 26:5 103: towards [5] 42:8 153:21 199:16 1 274:1 278:9 22 241:1 243:5,16,20 244:12 259:
13 125:14 150:17,21 157:15 160: 264:9 267:6 Treatment [125] 3:22 5:4 6:22 14: 9 261:22 262:12 268:19,19 270:
16 233:6 257:18 268:22 276:22 toxicities [6] 81:2 222:3,6 223:17 4 23:16 39:4,9 40:3,20 43:14 44: 12 271:13 277:4 281:20 287:21
302:2 224:18 293:11 17 49:12,13 63:15 64:22 65:8 73: 288:13,14 291:13 298:5 300:13
thoughtful [2] 233:17 259:8 toxicity [16] 11:19 94:19,20 131:15 17 76:9 77:21 78:14 82:2,22 83: 309:2,3,13 310:12 312:16
thoughts [4] 81:18 211:21 222:17 132:18 176:18 189:12,16 206:8 18 86:22 88:19 100:7 106:19 109: tricky [1] 294:12
235:10 210:11 241:8,8,9,11 263:21 265:1 7,17 113:14 114:16 117:11 118:6, tried [1] 189:14
Thousands [1] 215:9 Tracey [1] 2:17 14 119:9,20 121:4,8 122:15 124:3 triglycerides [1] 104:13
three [34] 9:20 10:19 13:11 54:17 track [7] 85:13 91:3 93:9,13 100:5 131:1,13 134:9,11,18 136:10 137: trillion [2] 19:6,7

Sheet 26 terrific - trillion
trim [2] 67:21,22 unclear [2] 32:12 142:13 297:12 value [5] 40:16 121:14 123:18 129:
triphosphate [1] 62:12 uncommon [1] 19:7 untilB-and [1] 104:19 12 185:13
triply [1] 272:16 Unconfirmed [1] 24:16 untreated [2] 112:15 120:22 values [1] 129:9
trough [3] 277:8,22 301:4 unconscionable [1] 201:7 unusual [1] 98:20 vantage [1] 206:14
true [18] 43:15,18,18 62:19 63:3 69: under [17] 14:4 63:20 65:3,13 116: up [70] 4:14 9:22 10:20 12:2 17:1,3,
variabilities [1] 41:16
20 71:14 116:19 117:21 160:15 6 144:3 189:22 210:8 211:19 212: 19 19:7 26:12 27:3 32:16 34:1 35: variability [7] 27:3 41:18,21 44:14
165:5 200:11 235:3 239:12,20 7 270:11 286:3 287:21 288:13 19 49:1 53:5 82:15 88:20 96:21 53:16 69:1,14
272:19 285:20 300:6 291:16,17 292:10 104:9 105:19 110:5 118:19 119:3 variable [6] 43:21 45:21 52:21 53:
truly [5] 54:21 65:5 81:18 167:18 under-represented [1] 114:11 125:9 132:21 133:13 136:14 141: 5,6 83:1
280:4 undergo [3] 23:16 24:6 45:17 14 142:8 147:10 152:18 157:20 variation [1] 27:1
try [17] 76:10 84:4 95:2,13 97:3 underlie [1] 58:1 164:22 165:15 171:7,20 172:4 variations [1] 281:17
103:20 105:17 124:1 168:9 192: underlying [1] 76:21 173:17,18 176:8 186:6,11 199:10 variceal [2] 110:20 167:9
16 197:6 219:11,15,16 272:11 underscore [2] 216:19 246:7 200:13 201:1 203:7 206:12 212:1 varices [1] 45:14
282:8 301:20 understand [31] 94:17 96:3 102:5, 213:1 214:10 215:15 220:4 221:6 variety [11] 25:10 52:9 61:2 78:4
trying [12] 121:13 145:10 152:13 10,12 109:16 113:14 114:15 156: 226:19 228:16 229:12 245:8 248: 79:5 205:13 214:7 216:22 245:20
163:21 224:12 243:11 248:21,22 12 164:4,9 172:16 176:19 179:5 18 256:4 257:9 266:2 276:1 283:5, 277:2 298:22
255:4 270:4 294:5 295:22 185:12 189:13,15 192:3 193:9 22 297:8 299:1 301:16 302:6 303: various [8] 21:1 32:9 45:10 76:5
tumors [1] 184:10 195:8 215:4 218:2,10 220:21 222: 4 304:15 165:3 181:14 184:8 290:1
Turcotte [3] 128:16 129:1,7 12 224:17 227:19 229:4 242:9 up-front [1] 262:14 variously [1] 120:19
turn [7] 4:8,11 63:9 74:17 129:20 303:11 311:6 up@ [1] 224:5 vary [1] 162:4
196:19 277:22 understandably [1] 219:3 upcoming [1] 26:21 varying [2] 20:16 33:5
turned [1] 23:17 understanding [10] 45:7 62:17 update [1] 167:3 veering [1] 229:21
turnover [2] 82:3 135:4 114:9 192:7 251:5 264:18 266:7 updated [3] 11:7 15:13 22:3 venous [1] 167:8
turns [1] 285:8 267:11 293:12 300:4 updating [1] 21:15 venture [1] 119:20
twelve [1] 171:4 understands [1] 94:9 upper [7] 53:12,12 63:4 110:5 304: versus [13] 14:2 36:18 42:1 69:6
Twenty-four [1] 64:4 understood [6] 27:18 68:14 132:7 3 309:10,22 71:20 74:12 111:7,14 201:1 215:
twice [2] 137:5 141:18 220:6 286:18 293:21 upwards [1] 247:11 20 235:17 246:17 259:15
two [49] 13:11 14:21 19:10 35:4,7 undetectability [1] 71:22 urban [1] 97:21 vertex [2] 91:16,20
37:11 51:22 56:6 81:10,12 85:11 undetectable [4] 120:20 127:5 urge [1] 80:13 vertical [1] 287:1
87:15 88:16 90:18,21 94:19 101:5 165:19 238:17 urgency [4] 73:10 228:19 266:11 vertically [1] 290:5
113:7 116:2 119:14,17 133:6 140: undetectableB-again [1] 123:8 300:7 viable [5] 163:6 179:12 244:8 251:
20 144:15 155:10 158:12 159:18 undiagnosed [1] 22:10 urgent [2] 113:20 261:11 15 255:20
166:3 168:4,5,11 171:19 174:19 unduly [1] 230:15 urging [1] 296:11 vice [1] 174:1
175:16 186:10 201:2 240:20 251: unequal [1] 113:7 usage [2] 102:6 288:1 Videx [1] 261:3
22 266:3 273:22 278:21 290:12 unequivocal [1] 217:3 useful [6] 24:15 44:11 130:13 140: Vierling [39] 2:20 3:16 6:2,2 7:20
291:14 292:10,11 301:5 303:19 unequivocally [1] 146:2 3 207:9 285:17 15:15 37:12 50:7,15 83:15 84:7
304:1 310:8 unforeseen [1] 204:6 usefulness [1] 229:6 99:14 129:10 143:17,20 153:2,3
two-day [1] 227:2 unfortunate [1] 186:22 users [4] 99:2,3 312:10,16 161:6,7 167:2 170:6,7 203:14,15
two-fold [1] 162:2 unfortunately [4] 60:17 64:18 uses [1] 37:22 216:16,17 220:17 223:20,21 227:
two-log [2] 40:17 70:9 150:17 275:22 using [28] 37:9 40:7 63:12 65:18 22 228:2 246:6,7 254:15,20 273:
two-part [1] 106:15 uniform [2] 139:18 155:8 118:15 120:6 123:8 130:8,13,20 22 277:5 278:8,20
two-plus [1] 133:21 uninfected [3] 27:19 28:2 30:13 133:6 144:22 147:1 155:20 158: Vierling=s [3] 112:21 116:16 180:
two-thirds [2] 18:2 255:22 unintended [1] 181:9 15 160:12 164:21 166:5 185:11 21
type [15] 32:22 35:14 36:3 70:1 unique [1] 300:5 192:22 223:3 255:12 263:16 283: view [9] 52:3 177:15 201:8,22 221:
125:21 166:12 169:15 182:16,17 uniqueness [1] 281:4 18 290:12 291:10 299:14 312:15 12 250:3 253:14,20 306:7
208:4 214:21 218:16 248:9 271:5 unit [3] 43:1 47:5 286:11 usual [1] 152:17 viewB-I [1] 306:22
295:17 United [11] 17:16,22 20:17 22:8 74: usurp [2] 52:4 74:19 viewed [1] 280:22
types [11] 56:6 62:14 151:14,16 14 79:2 97:20 113:12 245:18 280: utility [4] 66:18 93:18 101:16 182:viewing [1] 242:10
169:1 181:2 182:3 185:13,15 309: 9 304:1 19 viewpoints [1] 119:15
19,20 University [6] 3:19 4:21 5:12 16: utility-Bnot [1] 101:15 views [1] 198:17
typical [2] 25:18 27:8 14 190:17 191:2 utilization [4] 67:9 77:8 79:15 276:
vigorous [1] 55:13
typically [2] 119:13 160:18 unknown [2] 141:13 167:14 19 Viral [99] 3:12 15:13 16:3,22 18:16
unless [4] 132:11 197:20 284:4 utilize [1] 181:10 27:1,2,8,11,15 28:9,12,15,19,21
U 289:18 utilizing [1] 138:17 29:1,5 30:5,10,21 31:18 32:22 33:
U.S [10] 10:16 18:3 21:8,12 22:19 Unlike [2] 7:6 36:20 4,10,20 34:21 37:5,16 39:18,21
75:22 245:11,18 303:20 304:22 unlikely [2] 39:12 40:19
V 40:5,7,11 41:9,19 42:16 43:14,20
ultimate [6] 50:19 59:15 82:6 176: unmet [3] 179:22 184:2,13 VA [1] 5:7 55:15 56:1 57:16 62:14 63:13 69:
16,18 224:14 unnecessary [1] 261:6 vaccine [1] 50:21 4,6,17 71:21 90:3 113:10 118:18
ultimately [8] 30:10 56:19 80:1 83: UNOS [1] 79:4 vaccines [3] 181:12 186:4 251:8 120:4,11 121:3 122:21 124:9,16
13 93:15 170:16 247:13,18 unproven [2] 52:12 136:4 valid [5] 136:2 146:10 176:5 245: 125:11 127:4 130:11 134:21 135:
unable [2] 195:22 196:8 unpublished [1] 146:21 16 246:1 22 140:5,6,11 144:1 153:5 158:15
unaddressed [1] 17:11 unrealistic [1] 263:5 validate [1] 136:11 162:11,22 165:9,14 166:22 169:2,
unanimous [1] 311:16 unreasonable [1] 256:6 validated [5] 79:20 139:13,22 240: 20 170:1 175:8 180:11,19,22 181:
unapproved [1] 295:3 until [15] 30:10 38:3 95:17 103:14 18 261:15 14 183:5,10,22 184:12,21 200:2,
unavoidable [1] 217:7 115:1 151:22 232:20 239:3 256: validity [1] 122:15 21 220:15 239:22 240:5 243:3
unbalanced [1] 228:18 15 272:22 283:12,14,19 296:15 Valley [1] 20:19 253:2 267:6,12 282:13 285:1 307:
unboosted [1] 301:3 valuable [1] 211:22
Sheet 27 trim - Viral
21 310:14,18 164:8 168:12 179:3 180:5 181:1 16 64:12 66:9,13 68:9,17 77:7 78: works [10] 130:17 200:1 231:5 232:
virally [1] 56:12 192:13 193:18 198:1 202:10 204: 13 83:10,12,12,16,19 84:4,8 89:7, 4 245:10 254:6 297:11,15,18 303:
viremia [7] 54:6 127:1 128:2 144: 17 205:2 211:19 212:7,10 214:4 9,11 90:1,11,20 93:17,19 99:12 14
22 160:21 161:3 279:10 220:3 224:13 229:3,9 250:20 251: 101:3,6 102:5,6 106:3 107:19 108: world [15] 17:9 20:15 28:20 29:1
viremic [1] 279:16 3 254:5 255:9 265:3 270:11 271: 4 109:9,10 117:6,7,18 120:3 121: 42:18,20 43:2 89:7,11 188:4 202:
virions [3] 19:6 29:15 162:1 20 277:18 287:21 288:14 289:8 22 126:7 127:3 133:2 136:3 138: 7 236:1 245:17 247:19 277:1
virologic [26] 15:5 51:12 58:19 63: 291:16,17 298:5 302:18 308:11 11 139:21,22 140:1 142:10 149: worldwide [2] 11:1 21:7
11,17,17 64:3 65:4,7,18 70:8,10, 311:20 17,18 151:14,21 152:18,20 153:4 worms [1] 252:2
12 72:3 75:11 117:20 120:18 123: ways [9] 47:7 60:13 61:3 99:1 130: 154:5,6 157:8 158:16 160:18 168: worried [1] 283:9
17 161:11,15 166:14 192:1,5 193: 19 155:1 234:1 271:12 310:4 1,2,5,10 170:20 171:4,6,8,10,20 worries [1] 301:10
4 196:4 236:7 weak [2] 182:11,15 172:4,7 173:10,14 175:2 176:4 worry [1] 231:12
virological [1] 82:7 web [2] 8:1,2 177:15,19 178:7 181:13 183:5,15 worsening [2] 127:14 150:13
virology [1] 292:17 website [3] 86:9,12,15 184:4,11,11 185:10 186:2,4,11 worst [2] 217:18 276:6
virtually [4] 35:8 225:7 278:9 303: week [7] 32:16 42:9 116:2 163:17 191:9 193:10 197:6,16 204:9 205: worth [6] 159:7 164:5 210:9 230:6
18 164:6 166:3,7 8,10,12,14,16 206:1 208:9,18 210: 235:13 255:11
virtue [1] 132:17 week=s [1] 164:5 15 213:10 217:8 219:11 220:3 worthy [2] 170:5 243:12
virus [63] 18:5,7,8,22 19:4,10,14 weekly [1] 193:2 226:19 228:15,15 229:6 234:22 wouldn=t [9] 64:19 154:19 157:7
20:20 23:18 27:16,16 28:4,6 29: weeks [62] 26:7,9 37:19,19 39:11 237:21,22 238:2 245:3 247:13 204:13 211:10 212:4 245:9 266:
13 31:7 32:5 33:18,22 34:7 35:9 40:18 41:5 58:20,21 64:4 65:10, 249:21 251:4 255:15 256:18,20 22 271:7
37:14 39:11 40:20 44:2,2,3,4 52:9, 11,19 70:9,11,13 72:1,1 85:10 91: 257:19 258:1,12 262:18 264:20 wrist [1] 240:2
16 55:11,17 57:14 61:3,5 63:20 19 99:21,22 100:7 109:9,10 116:3, 269:15 272:4,13 278:15 280:6,10 write [1] 138:9
69:5 82:4,6 84:21 133:2 144:2,8, 7 118:10,16 119:14,17 120:21 283:13 285:15 288:1 291:3 296:4 writing [1] 173:14
10 145:1 147:2 149:13 158:19 121:4,9,20 122:2 123:11 132:21 299:14 302:1,2,6 312:4,21 written [3] 8:5 132:10 172:20
160:7 163:15 165:17 175:15 183: 133:1 139:15,16 143:2 155:11,11, William [2] 2:24 3:24 wsd [1] 310:18
15,16,20 188:1 237:13 242:18 13 156:19,19,21 157:19,22 159:12 willing [3] 175:2,12 298:16
272:1 282:11 287:1 293:13,17 161:3 166:3,22 168:17,18 192:13 window [2] 37:18,21
X
297:21 252:13,13,22 263:7 264:6 Wisconsin [1] 5:2 xenograft [1] 184:9

virus-specific [1] 282:17 Weight [3] 69:7,21 164:1 wish [4] 9:6 52:1 172:8 208:8 Y
virusB-you [1] 124:18 weight-based [1] 71:3 withB-if [1] 230:21 year [24] 10:18,21 22:14,17 23:15
viruses [2] 46:13 231:7 welcome [1] 106:9 Within [32] 19:11 22:22 27:4 32:16 45:7 48:4,5 54:15,18 74:7 86:14
visible [2] 17:10 160:20 well-characterized [1] 193:15 40:11 45:6 59:6,20 61:5,11 62:20
106:17 136:8 137:6 141:18 146:4
vitro [2] 176:10 184:9 weren=t [2] 104:19 254:16 63:1,13 64:12 65:10 67:1 73:20
149:18 168:1 215:7 228:14 252:
voice [3] 107:7 119:14 124:5 whatever [14] 29:20 31:9 84:21 74:7 85:10 121:19 162:10 234:11
21 281:10 292:2
voices [1] 107:8 129:2 146:22 191:20 198:15 205: 257:14 262:8,10 271:18 274:18,
year,@ [1] 250:1
VOLUME [2] 1:6 86:11 15 220:2 221:2 250:1 256:19 269: 19 284:7 292:2 302:12 308:12
year-Bwell [1] 252:21
vote [1] 226:17 8 276:18 without [27] 57:1 81:6 93:6 100:22 years [68] 10:4 17:18 20:22 25:17
Voting [1] 2:13 wheels [1] 193:11 126:10 129:16 131:22 148:20 149:
26:20 27:7 39:10 46:1,14 49:1 50:
VX950 [2] 94:16 103:3 whereas [1] 119:7 10 160:6 161:1 168:4 182:2,7 208:
1 54:3 55:3 57:2 64:9 73:6 74:5
Whereupon [2] 171:11 313:1 21 212:11,13 217:12 240:10 247:
W wherever [1] 139:5 5 265:19,21 279:10 297:4 298:12
84:13,13,15 85:1,18,21 86:1 87:2,
wait [5] 64:11 205:8 232:20 249:22 8,11 89:1 100:15 101:7,9 103:2,9
whether [43] 13:7,8,15,21 14:9 32: 304:21 306:4
104:1,5,9,15 105:8 136:1,13 137:
270:12 11 36:21 40:3 62:15 80:4 124:13 woefully [1] 275:2
waiting [17] 79:4 153:12,16 154: 11 141:12,14 142:1 148:4 149:9
136:2 139:20 143:5 150:3 153:5 women [7] 38:19 45:3 46:11,12 160:10 168:4,6,11 175:17,22,22
13 214:12 215:8 216:21 217:12 160:10 161:10 162:13 168:9 191: 188:14 201:14 308:19
219:20 221:11 222:19 223:8 228: 176:2 187:2,2,3 241:11 274:18,19
20 197:10 201:20 203:4 205:3 won=t [4] 101:1 207:9 288:19 300: 286:4,13,19 288:1,7 289:5 296:4
13,14,17 231:22 276:4 216:1 218:2 224:2 244:6 246:19 10
Waiver [1] 7:22 297:5
247:13 265:9,14 267:15 274:6 wonder [2] 159:19 160:9 years-Band [1] 39:22
waivers [2] 7:17 8:4 279:10 282:16 284:15 296:14 297: wondering [3] 85:21 211:17 300:
walking [1] 213:12 yellow [2] 69:2 71:6
13 299:20 304:12 305:22 16
wall [1] 109:21 York [6] 5:5,16 86:7 87:10 89:20
whichever [1] 295:15 word [2] 84:22 307:17 98:4
wanes [1] 286:20 white [4] 47:3 88:15 89:3 309:10 words [18] 30:5 44:19 65:1 114:1
wanted [10] 66:12 115:1 126:2 young [3] 45:2 46:12 291:5
whites [9] 75:18 201:1,9 304:3,14 118:10,15 131:12 132:1 149:1
younger [1] 292:8
141:2 158:2 190:22 193:21 218:6 306:9,9 307:3 310:19 151:15 164:15 165:14 176:22 215:
284:14 312:6 yourself [2] 16:7 165:15
whoever [1] 207:8 17 224:5 249:7 252:16 305:4
wants [2] 172:2 243:15 whole [11] 38:2 50:4 59:13 77:4 work [27] 22:16 34:8,12 42:5 73:22 Z
warrants [1] 200:11 157:9 205:7 227:2,14 231:11 299: 92:1,2 132:7 164:20 189:19,21 zero [5] 29:15,17 30:6 31:19,20
wasB-and [1] 137:4 1 309:11 190:12 194:19 200:1,20 227:19 zone [1] 292:12
Washburn [5] 2:12 5:6,6 9:21 10: whom [8] 134:18 141:19 222:19 229:16 245:9 256:15 262:14 269:
6 235:22 264:20 279:7 297:19 306: 18 284:2 290:19 303:13 309:14,
Washington [2] 4:21,22 19 15,17
washout [1] 158:21 widely [1] 148:6 worked [8] 85:5,7,12 165:1 191:4
wasn=t [7] 131:19 157:11,20 160: will [179] 4:17 6:11 9:2,9,10,18 10: 242:3 263:8 310:5
9 253:13 254:12 305:11 1,11 11:5,6 13:2 15:12,14,16,17, worker [1] 26:3
waterfront [1] 267:1 18,20 16:22 17:3,6 19:1 21:2 25:3 workers [2] 24:8,9
way [52] 10:18 29:11 33:16 52:4 85: 28:4,6 37:12 39:22 48:5 49:19 50: working [7] 49:22 59:12 85:2 125:
15 90:8 95:10,13 106:17 109:19 7,8 53:13 56:4 58:14 59:7 61:14, 8 196:12 272:10 297:14
114:14,22 117:4 131:4,5 133:3
Sheet 28 Viral - zone