You are on page 1of 35

0.

1 - 8:00

1750 [1] 1:10 220 [1] 4:4 40 [10] 63:18,19 64:5 87:1,4
0 18 [10] 62:22 69:18 133:1 144: 224 [1] 4:6 113:2,8 134:22 212:7 351:17
0.1 [1] 154:6 18 152:11 257:15 258:3 259: 229 [1] 4:8 41 [1] 3:14
0.5 [1] 206:6 7 276:19 317:6 239 [1] 4:10 48 [1] 65:2
0.55 [1] 136:2 18-gram [1] 133:2 24 [24] 53:9 59:11 65:2 154:21,
0.75 [5] 88:14,19 89:3 92:4,7 180 [1] 295:19 22 159:13,22 165:1 166:14
5
5 [30] 3:3 64:21 66:2,5 69:20
1 183 [1] 3:26 169:5,6 171:12,15 172:5,17
95:5 127:18 133:3 136:9,11
1 [21] 89:11 91:11,20,21 92:3 18th [1] 220:17 173:14,17 174:21 176:3 178:
19 [2] 63:3 276:19 18 179:6 216:5,8 353:15 140:4 151:17 164:15 166:10
114:8 121:22 127:9 135:22 169:7 175:19 176:2 178:11
151:22 165:14 191:4 206:6
1934 [1] 28:5 24-hour [5] 66:3 173:3 174:
1937 [1] 28:5 17 175:18 337:22 188:19 201:2 206:10,11 223:
217:1 222:16 234:12 236:14 13 234:13 257:16 258:4 305:
269:2 322:18 333:8 340:8
1938 [2] 28:10 29:20 243 [1] 4:12
1945 [2] 141:6,6 249 [1] 4:15 11 321:16 340:7 345:22
1,000 [1] 105:2 5-fold [1] 206:9
1-day-old [3] 119:16 120:21 1962 [4] 28:17 29:11,21 30:11 25 [4] 39:9 88:5,7 108:18
1966 [1] 29:17 256 [1] 4:17 5-hour [1] 204:4
122:17 5.5 [3] 95:3 203:17 204:2
1-point [1] 359:13 1968 [1] 29:22 260 [1] 4:19
1971 [1] 30:5 267 [1] 4:20 50 [11] 61:12 69:20 86:2 108:4
1-year [1] 247:21 130:1 140:13 166:20 198:9
1.0 [1] 154:7 1973 [1] 30:10 27 [1] 189:7
1986 [1] 143:19 28 [2] 268:13 269:8 269:19 346:10 351:17
1.3 [6] 257:13,14,21 259:4,8, 57 [1] 143:14
10
1989 [1] 30:19 28-day-old [1] 273:16
1994 [1] 31:8 29 [1] 1:6 58 [3] 39:1,8 142:1
1.5 [2] 89:7 92:3
1.8 [1] 91:11 1995 [2] 31:11 227:18 2A [1] 148:20 6
1/2 [2] 95:5,6 1997 [1] 31:12 2B [1] 148:21 6 [49] 55:10 88:22 94:5 117:10
1998 [2] 31:17 32:1
1/2-year-old [1] 192:19
1999 [5] 11:4 42:3 53:8 75:16
3 119:4 120:6 121:18 122:7
1:00 [1] 217:3 3 [41] 17:7 21:20 23:19 66:5 123:2 125:17,18 131:1,9 132:
306:4
10 [37] 3:8 32:20 59:13,22 61: 91:9 104:15 120:21 133:3,16 2,3,9,11 133:7 151:14 152:8
12 63:18,22 84:11 86:22 112: 2 143:13,16 144:20 157:1 163: 153:2,5,7 154:20,21 159:6,12,
18 113:7 119:17 127:19 142: 2 [51] 17:4 60:6 62:9 73:1,10 7 165:1 166:14 170:7 173:14 14,20 160:17,20 171:10,13
9 150:14 151:3 154:8 155:12 87:8 89:7,12 91:21 92:2,4,21 176:4 178:17 179:6 183:8 189:8 204:15 212:4 236:7
156:4 157:8 159:7,9 160:9 94:6 95:6,6 104:14 120:5,21 191:21 203:15 204:3 206:12 246:9 257:12,15,21 259:5,8,
170:9,12 203:6 246:2,9 262: 127:6 129:21 130:12 131:8 212:8 215:19 223:7 247:1,10 11 283:19 284:19 305:11
5 264:12 285:19,20 315:2 133:16 141:22 142:18 152:5 257:18 258:7 262:6 264:6 340:4 361:17
328:4 358:17 359:15 361:18 153:4 159:19 163:5,7 165:14 276:10 286:14 334:10,10,11 6-hour [2] 66:4 166:15
10-fold [1] 206:12 182:19 192:19 200:2 201:2 352:4 6-hours [1] 54:10
10-minute [1] 147:8 204:15 205:22 223:3 236:6, 3-day-old [1] 119:16 60 [1] 269:6
10:55 [1] 147:9 15 247:1 257:15 258:3 259:6 3-hour [5] 173:1 174:16,22 600 [1] 345:6
100 [5] 88:5 198:3 232:9 235: 260:5 276:10 295:21 333:9 204:1 337:22 612 [1] 142:17
18 307:16 334:9 340:8 345:21 3-year-old [2] 286:11,19 62 [1] 82:9
102 [1] 314:22 2-hour [2] 151:14 159:3 3:30 [1] 333:4 64 [1] 264:8
107 [2] 28:6 144:13 2.26 [1] 88:17 30 [15] 63:18 64:5 86:3 87:3 68 [1] 112:20
108 [1] 3:19
10X [1] 206:10
2.3 [1] 88:17 91:9 127:13 189:7 211:12 7
2.7 [1] 60:13 212:2 219:12 225:10 247:5
7 [28] 42:18 44:4 53:7 59:10,
12 [7] 142:17 159:22 170:9,12 20 [29] 22:22 41:12 42:18 44:3 277:9 296:17 342:12
232:14 276:22 277:10 13,22 60:16 65:3,7 112:17
59:14,15 60:9,15 63:18 64:2 300 [1] 110:17
12-hour [1] 149:22 113:7 118:22 119:17 123:5
87:1 107:15 108:9,14,19 144: 309 [1] 4:21
12:00 [1] 217:2 125:18 149:22 150:2,4 162:
11 149:21 150:17 151:14 30s [1] 277:4 19 189:6 191:18 192:8 193:4
122 [7] 66:2 93:22 164:13 166: 154:10 155:12 157:8 166:18, 32 [1] 200:3
9 175:17 178:10 215:11 272:18 285:19 305:11 314:1
20 170:16 191:5 277:9 308: 33 [1] 268:13 362:10
122-day [1] 170:4 16 340:5 35 [10] 66:2 113:8 134:22 164:
123 [1] 164:13 7,000 [1] 249:20
200 [1] 88:4 16 166:11 172:7 175:22 178:
7-day [2] 122:20 295:18
124 [1] 141:7 2000 [1] 44:13 12 179:16 214:11
13 [2] 220:11 276:22 7-day-old [13] 42:8 43:5 46:8
2002 [4] 32:5 46:4 47:11 53:5 35-day [1] 214:20 118:18 119:9 122:17,20 123:
13.2 [1] 235:9 2003 [5] 32:13 54:4 133:22 3M [1] 251:2
130 [1] 127:13 15 131:6,21 132:3,22 256:20
228:5 268:19
14 [5] 119:18 121:22 162:18 2004 [4] 46:11 59:6 62:15 72:
4 7-fold [1] 60:20
192:13 277:1 4 [29] 39:8 89:2 91:9,22 92:5 70 [3] 28:1 84:11 112:20
22
14-day-old [5] 130:3,20 131: 102:6 120:6 123:2 129:22 72 [1] 65:1
2005 [1] 64:15 74 [1] 3:16
4 132:1,5 2005P-0076 [1] 222:16 130:12,17 131:8 132:10 135:
147 [1] 3:23 20 136:12 138:15 139:4 151: 75 [5] 136:1 164:12 166:9 175:
2006 [2] 91:5 220:11 18 179:10
15 [7] 144:11 151:4 159:9 264: 2007 1:6[1] 22 152:5 153:4 188:18 197:
5 277:10 291:1 359:15 22 200:2 204:15 223:10 287: 79 [2] 30:15 316:17
2009 [1] 201:6
15,000 [1] 247:9 2014 [1] 303:3 15 341:3 342:22 352:4 8
15-minute [1] 333:3 2015 [1] 201:8 4,000 [1] 29:19 8 [9] 80:10
143:16 197:22 200:
150 [2] 38:22 83:16 2050 [1] 235:9 4-fold [1] 130:18 2 225:13 275:5,9 317:6 361:
153 [1] 38:16 20s 277:4
[1] 4-hour [2] 90:7 92:7 18
16 [2] 3:11 38:17 21 [1] 272:18 4.5 [1] 235:7 8-year-old [1] 143:16
160 [2] 54:16 94:1 22 [2] 28:15 170:16 4:05 [1] 365:21 8:00 [1] 1:7
80 - agent

80 [3] 86:5,17,20 acceleration [1] 245:17 16 126:6,14,19 127:3,4,22 3 59:18 66:3 77:11 177:14
acceptable [2] 26:1,12 128:3,5,9,10 129:4,6 132:19 218:7 244:22 245:18 255:9
9 accepted [5] 12:12 65:18 134:4,9 136:6,17 137:21 138: 280:2
9 [8] 3:5 63:19,20 149:22 165: 167:22 168:2 175:9 2,18,19 139:9 140:10,16 141: adult [18] 24:11 33:3 34:1 50:
2 179:3 188:21 358:19 access [2] 221:9 222:11 2,21 142:4,10,14 143:1,6,11, 8 51:1 63:6 86:18,21 109:8
9-hour [1] 42:20 accidentally [1] 220:18 21,22 144:1,3,7,14,16 147:6 244:9 248:5 250:1 258:16
90 [3] 42:19 44:4 59:13 accompanied [1] 248:6 153:19 166:21 188:6 198:22 259:3,10 324:9,15,20
92 [2] 30:15 316:13 accompanying [1] 92:11 204:14,16 205:19 206:10 adulthood [1] 212:4
93 [1] 31:1 accomplished [2] 21:16 212: 208:11,18 209:8 213:3 228: adults [9] 73:3,5 109:15,16
94 [2] 169:2,7 12 21 229:10 267:15,22 268:10, 187:18 255:3 259:1 277:3
95 [1] 169:8 accordingly [2] 190:17 216: 12 269:12 270:7 273:1 276:5 301:2
97 [1] 90:8 17 284:16,21 286:4 294:21 295: advances [1] 108:5
99 [3] 53:14 90:8 272:15 account [1] 152:13 17 299:6,13,19 300:2 305:10 advantageous [1] 341:18
A accounted [1] 140:16 307:21 309:12 310:15 311:6, advantages [1] 289:12
A's [1] 141:10 accumulate [1] 248:12 16 318:16 321:6,19 322:9 adverse [17] 25:19 26:9 33:
A-beta [25] 236:4,10,11,19 accumulating [3] 52:12 53:1 326:10 327:3 333:4,14 336:5 22 34:6 36:19,21 37:10 38:4,
67:13 339:1 340:13,19 342:5 343:7 20 39:4,13,14 204:1 244:5,9
237:1,1,5,11,13,15,19 238:1,
3,4,8,11,18,18,21 239:1,3,7,9
accumulation [3] 162:6 235: 345:5 350:8 351:14 353:3 248:12 323:8
263:2,4
12 236:19 354:12 358:8 364:10 adverse-reaction [1] 26:20
A-beta-5-CQ [1] 238:2 accurate [1] 38:7 acute [5] 34:10 239:5 274:7, adversely [1] 17:11
a-la-carte [1] 254:1 accurately [2] 104:7,17 18 275:20 advice [1] 334:17
A.D [2] 235:7 239:8 achieve [2] 153:20 295:22 acutely [1] 274:10 advise [2] 218:16 219:3
a.m [1] 1:7 achieved [2] 101:1 207:12 add [11] 107:4 132:16 154:14 ADVISORY [6] 1:5 2:4,12 5:5
abdominal [1] 73:7 acid [2] 17:18 194:22 156:6 249:3 287:17 313:21 9:9 218:11
aberrant [2] 75:4,12 acidosis [1] 185:5 329:11 333:21 335:13 364:1 AERS [5] 36:21 37:19 38:5,13
abilities [1] 194:6 acknowledge [1] 70:11 added [3] 11:10 61:10 329:5 39:18
ability [20] 34:6,8 35:3 37:22 across [11] 82:7 90:7 122:11 addict [2] 221:5 279:6 aesthetically [1] 251:4
161:17 165:16 184:3 233:3,
166:1 169:8 271:3 315:1,2,4 addicted [3] 226:15,18 279:7 affect [13] 17:11,19 47:8 119:
14 258:9,14,20 259:12 260:4,
357:7,8 addiction [5] 223:11,14 225: 12 156:17 210:16 236:9 239:
11 309:17 311:13 325:5 346:
Act [8] 28:11 31:13 32:6,14 13 226:17 228:15 6 258:19 259:12 280:21 296:
15 357:6
62:3 116:5 328:3,3 addictive [2] 226:5,6 16 339:20
able [29] 38:16,22 46:14 61:8 acted [1] 39:10 adding [3] 61:17 137:20 329: affected [9] 119:6 124:14
65:3 72:12 85:6 105:3,8 116:
ACTH [1] 317:11 13 138:22 159:5 240:18 278:11
6 126:21 149:12 151:2 152:3
Acting [2] 2:2 9:19 addition [10] 11:19 13:11 38: 298:15 302:3 339:1
153:19 155:9 179:22 196:17
action [6] 30:12 70:3,6 209: 6 45:6 46:5 244:20 245:3 affecting [4] 165:15 257:10
22 294:16 313:7 246:17 248:8 330:21 349:10,11
226:12 276:5 277:8 308:6
344:6 349:8 357:1 359:9,22
actions [7] 17:20 222:3 223: Additional [17] 11:9,18 36:4 affectionately [1] 118:17
360:11,20
20 240:16 283:4,7 322:11 65:9 69:12 87:12 162:2 223: affects [3] 19:18 235:7 299:
abnormal [3] 317:9 359:8 activate [11] 76:14 129:12,16, 7 241:12 244:7 303:22 313:6 12
360:3
17 131:19,19 299:3 300:2,6,8, 319:6 333:18,19 334:2 365: afford [1] 114:6
abnormalities [3] 19:21 25:7 9 19 afternoon [3] 14:13 147:3
26:19
activated [7] 80:6,19 107:8 additive [2] 70:18 87:20 260:18
abnormally [3] 98:4 100:20, 128:22 138:2 139:16 299:16 address [15] 10:11 14:14 24: afternoon's [1] 40:16
21
activates [2] 79:20 129:10 4 89:16 120:18 191:13 209: afterward [1] 208:12
above [4] 64:22 87:1 88:6 activating [1] 299:8 17 219:6 222:6,19 224:6 272: afterwards [3] 160:20 192:12
330:8
activation [29] 79:19 80:3,12 4 280:10 294:13 365:8 355:2
absence [9] 68:19,21 82:4 90: 90:21 95:11 107:12 129:5 addressed [4] 73:21 244:14 age [58] 17:8 21:21 23:19,22
131:6,8,15,16 132:2,5,8 139: 288:16 333:14 24:6,7 32:4 37:20 38:18 62:
2 91:14 103:15 250:13 267:
11 317:18
6 235:15 236:8,13,16 237:9, addresses [1] 9:5 10 69:5 101:20 102:21 108:
absent [1] 99:10 12,17,19 238:14,20 299:7,17 addressing [2] 277:21 320: 19 118:22 119:4,13 122:11
300:3,15 17 123:5 125:18 127:13,14 140:
absolutely [9] 122:2 130:6,
20 132:15 135:6 206:18 214:
active [3] 241:16 272:11 280: adds [1] 111:8 4 142:1,17 143:14 144:20
19 292:1 342:20
4 adenomatoid [1] 21:11 150:4 162:18 163:5,7 193:1,
abstract [3] 186:15 282:6 activities [1] 255:7 adequate [7] 24:19 25:20 26: 15 200:2,2,3,3 211:12 212:2,
309:11
activity [8] 62:10 149:3 229: 4 29:8 246:8 310:22 354:15 4,7 220:13 258:16,17 259:3
abstracters [1] 281:21 21,21 238:16 241:22 360:14, ADHD [1] 316:20 264:6,7,16 268:13 275:6,9
abuse [12] 83:12,18 220:3 14 adjourned [1] 365:20 285:20 307:21 316:18 321:
221:12,22 222:7,8,11,18 223:
actual [5] 114:15 152:16 153: adjunctive [3] 97:16 99:3 16 345:21 359:16 364:21
11 225:1,8
8 191:17 204:22 250:18 age-matched [1] 122:14
abused [5] 83:16 222:12 226: actually [138] 43:2,17 44:7 45: adjust [1] 190:16 aged [3] 179:15 257:2 265:1
5,13 228:15
19,21 49:5 51:4,17,20 52:18 adjusted [1] 216:16 agencies [1] 12:7
academia [2] 66:16 99:2 54:21 64:5 65:1 67:16 99:8 administered [12] 25:7 34: agency [15] 27:17 36:18 37:
106:14 107:10 108:16 109: 11,20 42:19 57:14 59:22 63: 22 41:20 44:13,17 46:13 47:
academic [1] 325:21
20 113:18,20,22 114:10,17, 18 64:17 223:17 247:12 281: 22 59:1 66:1,17 72:21 220:8
Academy [2] 29:18 30:2
21 115:3,11 116:16,18 117: 22 351:9 326:10 332:21
accelerate [2] 51:8,12
accelerated [5] 31:13 77:17 20 118:5 119:12 120:1 122: ADMINISTRATION [16] 1:2 agenda [2] 9:11 10:6
87:4 92:19 186:21
12 123:11,13 124:8,8,14 125: 23:6 37:12,14 39:17 43:7 44: agent [24] 76:22 88:11 89:2
agent - animals

106:22 166:1 207:15 248:13 alluded [4] 113:17 128:17 185:10 193:7 199:16 268:22 4 190:18 195:8 197:5,15 200:
251:16 252:22 253:12 259: 133:14 142:11 272:2,8 275:2 298:21 300:10 22 209:21 210:10 212:19
15,16,22 260:6 300:19 301:4, almost [6] 136:9 142:9 213: 312:9 313:21 315:10,16 316: 213:13 216:4 231:20 234:22
5,7 309:18 311:13 338:12 12 284:2 308:16 354:22 2 330:10,11 331:13 339:21, 236:3 238:13 240:2 244:2,5,
339:17,19 344:8 alone [16] 29:20 61:21 62:8 22 348:4 354:12 357:16 12,15,22 245:5,11,21 246:18
Agents [60] 3:10 11:8,14,21 64:13 67:17 73:8 115:17 118: Anand's [1] 193:13 247:3,11,19 248:2,9,13,21
13:1 16:4,8,15,20 19:6,9,14, 12 137:19 138:8 157:16 200: anatomical [1] 162:22 255:18 265:19 275:10 286:
14,20 20:5 21:17,18 22:8,10, 22 263:5,16 297:10,12 and/or [1] 116:21 13 302:11 304:5 309:18 311:
19 23:2 27:7 30:16 34:17 52: already [15] 10:5 75:21 80:4, Andrew [2] 200:14 345:20 13 317:16 318:19,20,21 320:
9 76:14 82:15,20 83:11 84:5, 7 167:5 180:9 227:9 232:8 Andy [1] 149:19 7 327:11 331:16 332:11 334:
8 97:16 106:21 153:22 194:4 236:20 261:6 262:18 290:3 anecdotes [1] 358:16 11 343:5 344:7 350:18 352:2,
242:17 250:9 273:14 274:4,4 293:17 351:21 356:4 Anesthesia [159] 5:11,20 6:1 3 355:20 356:1 360:2 362:21
281:14 282:1,20 283:7 289: alterations [1] 169:14 7:3,4,11,17 11:17 13:3 15:4, 364:5,15
10,16 293:14 294:9 297:18 altered [3] 17:20 214:16 215: 12,15,17 20:12,16 21:18 28:2 Anesthetic-Induced [8] 3:
308:13 322:12,22 323:22 4 35:12 36:3 40:3,7 54:11 55:6 12,17,22 41:6,8 107:22 108:2
324:18 328:20 331:16 342:3, altering [1] 107:6 57:8 68:21 84:19 86:10 94:7 183:12
6 343:5 357:9 alternative [10] 15:19 20:15 95:5 97:13 98:19 108:6,7 anesthetics [65] 34:19 51:20
ages [5] 121:22 327:18 336: 26:3 35:14 40:10 202:5 279: 109:6,17 116:11,16 118:8,9 58:11 67:2 71:15 83:22 114:
14 352:18 362:11 20 281:17 304:11 308:13 120:6 121:16,17 122:3,8,10 19 116:14,15 117:3,4,19 125:
aggregation [2] 234:2 239:1 alternatives [5] 22:6 34:16 123:7,15,16 124:2 125:18 10 129:12 131:18 138:5 141:
aging [1] 324:10 231:10 307:6 319:18 129:20 130:5 133:6,18 135: 3 144:14 146:12 192:22 194:
agitation [1] 244:21 alters [1] 349:9 16 136:7,13 139:4,20 140:1 2,4,11 209:11 213:7,11 229:
ago [15] 108:9,17 143:20 161: Although [31] 15:5 18:15 21: 141:12 142:13 144:3,9,11 10 230:11,17 232:17,21,21
10 162:14 167:7 189:22 234: 18 22:1 23:2 35:12 42:9 43: 145:10,18,19,19 146:6,10,19 234:13 242:8 245:19 246:15,
5 246:3 247:5 296:17 301:3 20 49:11 50:6 62:3 65:7 83: 150:1 164:21 165:1,2,2,4,7 16 260:22 263:7 264:21 265:
323:5 358:15 364:11 22 102:4 114:4,9,11 116:11 170:15,17 179:4 183:9,11 2 267:3 268:11 280:1 281:1,
agonist [2] 76:18 321:11 127:15 130:7 138:9 145:3 184:5 186:18 189:13 190:9, 8,10,22 286:16 299:12 300:1,
agonistic [1] 19:5 150:7 198:4 212:1 283:3 284: 11 193:8,10 194:15 196:4 6 302:21 310:11 317:17 318:
agonists [4] 76:14 82:18 181: 3 297:3 304:13 321:6 352:7 198:19 200:13 201:1 206:20 18 321:22 324:14 327:11
21 297:16 altricial [1] 101:10 207:3,12,14,16,18 208:9 209: 328:21 329:1,9 333:11 352:
agree [30] 109:5 277:14 302:5 Alzheimer [1] 233:6 17 214:22 216:3,16 234:12 11 362:5
309:13 310:1 311:17,19,20, Alzheimer's [17] 230:12,22 235:21 244:19 246:4,22 247: anesthetist [1] 141:21
21,22 312:1,2,3,4,5,6,7,8,9, 231:16 232:5,6 234:10,14 7,12,13 248:4 249:8 250:1,3, anesthetize [8] 163:22 184:
10,11,12,21 322:14 329:13 235:1,2,13,16 236:1 245:7,17, 12,18 251:8,11 253:1,5 255: 12 186:10 188:10 202:6,22
336:12 342:18 354:11 358:8, 22 246:5 263:3 15 256:3 261:17,21 262:3,3,6, 215:16 321:10
11 Amand [1] 308:18 10 263:4,16 264:12,19 265:6 anesthetized [16] 36:6 121:
ahead [1] 224:4 amazing [1] 358:9 279:20 284:11 285:9 298:7 10 168:18 169:5,13 171:20
air [2] 252:15 273:18 Amendments [2] 29:3,11 302:20 303:1,20 304:18 305: 172:5 186:4 192:20 195:14
airway [6] 301:18 302:10 304: American [1] 199:3 14 307:17 308:16 326:16,20 197:14 213:4 242:15 253:18
1,8 307:22 347:14 Americans [1] 235:8 328:6 334:13 349:19,20 361: 262:15 318:15
airways [2] 252:17 271:13 amnesia [3] 35:3,10 304:7 18,19 364:9,13 anesthetizing [3] 86:16 88:2
Akenhart [1] 296:7 among [4] 17:3 39:8 92:1 anesthesia-induced [5] 97: 187:15
Akil's [1] 314:2 328:20 4 115:8 146:3,7 147:19 angel [1] 83:14
AKT [3] 299:16,22 300:4 amount [8] 37:18 66:14 176: anesthesia-wise [1] 302:9 animal [60] 13:6 14:18 20:11
al [16] 19:1 42:3 46:4,10 53:4 19 214:13 216:10 285:11 anesthesiologist [18] 6:11 7: 25:10 26:3 36:17 40:5 43:7
59:6,8 60:15 61:6 62:15 64: 335:6 356:12 9,14 8:3,21 13:20 132:19 55:18 57:12 77:12 87:9 95:
15 65:16 72:21 88:14 90:10 amounts [4] 20:1 104:14,17 134:13 141:20 143:21 183: 12,18,22 96:1,18 97:6,11 107:
91:5 162:2 14 239:20 249:1,15 260:19 11 122:17 124:22 127:1,17
alarm [1] 208:18 amplification [2] 171:7,17 265:12 271:9 306:21 128:7 133:2 139:2 145:16
alarming [1] 239:14 amyloid [3] 230:22 231:20 anesthesiologists [10] 6:14 164:15 167:12 168:11 170:4
alcohol [27] 19:17 20:3 71:2, 232:4 145:4 249:3 251:11 287:9 176:1 180:19 202:15 205:2
13 77:7 84:12 85:21 103:19, anaesthesia [1] 198:13 306:18 310:14 316:3 320:6 232:3,14 233:3,6,6,7,15,20
22 104:3,4 105:1,4,18,20 194: Analgesia [12] 5:11,20 6:2 7: 340:14 234:1 240:21 265:2 277:6
19 208:20,22 209:4,6,9 210: 4 35:18 36:3 184:4 188:14 Anesthesiology [12] 6:5,8, 282:12 285:18 295:18 302:
17 221:1 222:22 227:1 278:6 203:1 273:5,5 308:11 12 7:6 8:17 108:6 110:1 199: 14 305:12 310:22 316:6 328:
279:9 analgesia/anesthesia [1] 3,6 246:12 256:13 294:17 17 343:9 350:21 356:13 357:
alcoholic [1] 105:16 184:21 ANESTHETIC [117] 1:4 2:4, 8
alert [1] 249:8 analgesic [3] 22:19 242:17 12 3:9 5:4 9:8 11:15 12:19 animal-reproduction [1] 25:
alkylosis [1] 120:12 349:5 13:18 14:2 16:4,8,14,20 19:6, 19
alleviation [1] 201:17 analgesics [1] 242:19 14 20:5 21:17 22:7,8,9,16,18 animals [114] 14:3 18:4 19:8
allow [13] 57:20 66:9 68:10 analogy [1] 208:20 27:7 30:16 34:17 35:4 41:16 25:4 26:18 30:8 33:7 35:17
99:3 121:7 126:12 162:2,5 analysis [8] 120:1 201:6 298: 52:8 54:13 55:5,10 57:5 58: 40:2 58:2 60:3 62:11 63:2,6
176:19 181:5 188:10 291:8 12,14 328:14 337:4,4 345:5 12,16 66:19 67:15 70:6 71: 66:6 88:21 91:8,12 93:9 119:
339:17 analyze [1] 32:3 10 84:18,21 88:16 89:22 97: 4,9,13,20 120:9,9,20 121:6,
allowing [4] 79:5,18 137:2 analyzed [1] 33:21 12,18 103:16 110:4 117:12 10,21 125:17,19 126:12 127:
243:10 Anand [31] 2:6 6:20 68:17 69: 118:20 120:2 128:8 129:14 3,8,16,20,21 128:5,8,9,14
allows [1] 177:3 2,14 100:17,18 101:8 184:19 143:17 178:11 186:2,3,3 187: 130:3,4,20 131:4,7,21 132:1,
animals - average

4,5,22,22 136:22 140:2,3 151: 65:3 79:14 90:22 91:1 92:22 approve [1] 29:12 assay [6] 152:7 154:4 157:5
11,13 152:4 160:3 163:22 98:12 104:1 107:1 114:1,16 approved [13] 22:17 23:3,4,6, 158:10,22 296:5
165:10,13 166:17 167:2 168: 115:8 122:7 128:21 150:16 18 29:20 30:3,16 31:11 33:3 assess [9] 20:13 31:20 38:4
5,16,17,19,22 169:4,7,10,12 152:16 155:8 156:1 158:7 42:11 47:20 356:5 180:10 242:7 268:1 291:8
170:7,11,13 171:9,18,20 172: 160:22 173:10 174:4,12 177: approximate [2] 49:4 87:20 343:3,8
4,9,18 173:17 174:1 176:6,7 9 186:21 235:16 236:4,15,18, approximately [11] 49:6 60: assessing [2] 23:21 361:5
179:15,16 180:8 211:2 214: 21,22 237:5,7,9,15,17 238:7, 7,12,20 73:10 76:5 82:9 88:4 assessment [16] 14:16 31:2
21 215:19,21 216:7 232:2,11, 10,10,14,20,21 239:1,7,9 241: 94:5 188:19 247:1 38:8 160:9 171:4 180:4,7
15 262:9,15 268:10,13 283: 16 242:1,3,4 256:16,19 257:5, APSF [2] 248:8 249:8 205:10,15 208:5 290:10 356:
14 284:4,7,18 285:2,21 291:7, 18,21 258:2 259:6 267:2 269: ARDS [1] 347:18 21 357:12 358:13,13 363:1
11 295:21 312:20 318:8 321: 3,7 270:11,17 274:8 294:20 area [22] 57:18 100:7 106:11 assessments [3] 47:16 197:
10 343:10 296:1 298:22 299:8 300:11 148:1 149:10 169:19 171:22 19 201:2
animals' [1] 165:15 338:21 360:3 361:5 172:1 191:10 203:19 206:6 assigned [1] 26:17
anisotrophy [1] 274:14 apoptotic [24] 11:6 12:14 43: 245:6 289:3 294:12 300:21 Assignment [1] 25:17
Ann [1] 345:20 13,17 48:13 49:19 50:3,18 319:11 323:18 325:11 327:9 assist [1] 15:22
announcement [1] 9:4 55:11 63:17 78:10 81:20 115: 340:9 358:4 359:20 assistance [1] 12:6
annual [1] 199:5 11 128:18 150:9 174:8 177: areas [16] 43:12 50:7,20 57:6 Associate [3] 8:6,7 274:20
anomalies [1] 195:18 18,21 274:12 282:5 297:11 130:16 150:8 155:13 181:14 associated [14] 11:13 16:14
another [22] 83:7 103:3 109: 300:13 329:6 351:3 188:17 244:6 245:7 267:8 18:14 19:19 22:4 77:7 214:
22 128:12 146:15 156:13 APP [5] 236:9 237:10,13,19 269:19 275:16 276:12 323: 15 236:22 244:21 256:2 274:
158:10 169:19 172:21 173:7 238:17 18 4 278:16 327:20 364:4
194:1 210:22 215:17 230:8 appear [5] 17:9 19:14 25:11 aren't [5] 82:2 84:10 187:17 association [5] 131:14 245:
302:16 309:22 320:22 335:6 53:18 309:9 196:13 309:4 21 246:11 247:19 293:4
336:9 348:16 351:12 357:16 appearance [2] 9:7,16 arena [1] 58:8 associations [1] 247:4
answer [17] 15:9 86:1,13 101: appeared [1] 65:2 argument [5] 89:20 90:1,16 associative [2] 244:8 248:11
3 133:19 200:5 213:18 214: appearing [1] 87:4 91:3 92:14 assume [4] 69:22 209:1 214:
18 231:1 243:9 277:8,10 285: appears [6] 12:15 48:17 49:3 arguments [2] 89:16,19 4 353:19
22 334:20 341:22 361:3 364: 106:7 160:21 352:2 Arlington [2] 4:3 220:9 assuming [1] 157:14
12 appendectomies [1] 141:10 Arm [2] 126:4 128:12 assumption [3] 136:20 214:
answered [2] 314:12 365:5 appendectomy [1] 141:8 armamentarium [3] 231:9 5 270:5
answers [1] 348:15 Applause [1] 365:17 320:2 322:4 assumptions [2] 297:21 298:
antagonism [1] 210:12 applicability [2] 14:20 310: armed [1] 306:3 2
antagonist [13] 42:12 43:9 11 Armstrong [13] 2:17 8:5,5 71: assure [1] 190:6
48:12 51:19 71:9 76:18,20 applicable [2] 24:7 271:16 16,17 273:21 275:12 311:22 asymmetric [1] 353:18
84:2 117:6,9,13 210:6,20 application [4] 29:12 32:3 313:12 319:8 327:12 336:12 Athena [2] 2:25 7:18
antagonistic [1] 19:4 227:18 279:5 358:11 atmospheres [1] 295:21
antagonists [7] 50:22 66:21 applications [2] 32:16 320: aroma [1] 250:11 ATP [1] 240:15
82:17 181:22 209:18 297:16 12 around [27] 5:6 76:7 83:15 atresia [1] 196:15
318:22 applied [4] 39:1 290:19 295: 86:9 101:6 115:17 126:13 attempt [5] 146:15 176:9 178:
anterior [3] 123:1 131:10 132: 17 327:13 163:4 164:13 169:2,7 170:9, 13 343:22 352:11
3 applies [1] 118:7 15 178:17 192:8 206:6 215: attempting [2] 14:19 180:17
anterodorsal [1] 81:15 apply [5] 35:3 118:9 291:10 20 224:2 258:17 283:22 306: attempts [1] 176:11
anti-emetic [1] 251:16 312:19 315:5 18 325:11 326:5 328:8 345: attend [1] 219:20
anti-epileptic [4] 194:21 279: applying [1] 180:8 13 363:18 365:2 attendance [1] 219:1
4,11 281:2 appreciable [1] 95:10 around-the-table [1] 332:17 attending [1] 6:22
anti-epileptics [2] 278:14,17 appreciate [6] 23:7 37:7 224: array [4] 107:12 293:1 301:7 attention [7] 76:19 105:22
anti-opioid [1] 225:18 20 243:14 266:17 329:22 360:8 182:14 248:3,5 266:12 285:
anti-P [1] 300:2 appreciative [1] 365:11 arrest [3] 291:17 331:11 346: 16
antibodies [1] 80:6 approach [25] 45:16 47:13 5 attenuate [3] 237:18 238:3,6
anticipated [2] 235:5,6 154:3 156:1 181:9 242:13 arrived [2] 44:7 80:3 attracted [1] 348:18
anticonvulsant [1] 82:19 251:18,20 290:12,13,18 314: Art [3] 4:5 224:18,19 audience [2] 200:6 243:20
Anticonvulsants [1] 83:20 19,22 334:18 336:21 337:12 arterial [11] 90:6 100:13,15 August [2] 220:11,17
antidote [1] 339:19 339:13 341:5,6,13,13 359:12 119:22 120:4,14 134:16 137: Australia [2] 200:15 213:9
antisense [10] 154:15 155:16 360:8,9 362:1 8 190:3 257:10,11 Australian [1] 344:1
156:6,11 157:11,15 158:14 approached [1] 280:11 arteries [1] 197:13 authority [2] 27:22 32:13
160:11 178:4 338:7 approaches [10] 156:20 165: arteriosus [3] 185:1 196:16 authorized [1] 223:12
anxiolysis [2] 35:2,10 19 175:14 180:3,16 181:10 343:16 authors [1] 145:5
anybody [5] 274:22 333:15 289:14 290:7,21 339:16 artery [1] 91:10 Automated [1] 348:20
334:8 363:22 365:3 appropriate [11] 20:13 33:13 Arthur [4] 2:33 3:11 5:22 13: automatically [1] 253:16
anyway [2] 273:10 308:1 56:11 202:18 208:13,14 308: 20 Autonomic [1] 240:9
Apaf-1 [1] 79:19 6 325:22 354:17 359:21 361: article [6] 11:6 168:1 185:16 autopsies [1] 361:20
apart [1] 42:19 21 186:13 306:4 309:11 available [19] 13:13 14:16 20:
apologies [1] 345:13 appropriately [3] 63:2 113: articles [1] 250:14 15,16 23:2 24:11 27:3,11 40:
apoptogenic [6] 83:12 84:14, 21 228:9 artificial [2] 187:10 193:10 10 52:19,20 73:6 146:10 169:
15 85:12,14 92:17 approval [13] 13:17,17 27:18 Aspect [3] 4:11 53:16 243:22 16 180:14 186:10 201:7 227:
apoptosis [78] 18:8,14,15 19: 28:1 31:13 34:4,7,13 36:17, aspects [4] 16:16 128:17 148: 10 331:17
8,15 20:12 43:11 50:9 51:3 18,20 38:15 39:5 10 201:18 average [1] 351:17
aversion - brain

aversion [2] 62:18 63:1 327:4 345:2 besides [1] 323:2 21 281:6
Avinza [1] 226:19 bath [1] 203:2 best [14] 24:1 32:5 45:16 47:2 blockade [5] 18:2,19 158:14
avoid [1] 255:20 batteries [2] 352:12 354:21 121:5 132:16 133:13 134:2 161:17 162:1
avoided [1] 40:9 battery [6] 290:13,18 348:20 286:6 304:17 306:15 328:3 blockading [1] 160:11
awake [2] 254:12 318:14 354:14 358:17,19 334:18 358:21 blocked [2] 35:22 155:16
aware [9] 10:7 107:9 213:9 bax [5] 79:16 98:6,10 155:6, beta [5] 230:22 231:20 232:4 blocker [1] 281:4
251:9 252:2 288:15,17 308:5 14 235:11,12 blockers [14] 82:21,22 83:21
340:11 bax-dependent [1] 79:15 better [7] 59:3 100:7 127:8 279:16,18 280:1,15,18,20
awareness [6] 198:20 199:4 Bcl [1] 129:9 133:10 179:7 215:20 284:1 281:4,9,13 327:8,10
221:14 250:4 253:1,12 Bcl-2 [1] 155:6 between [46] 17:4 29:20 30: blocking [6] 11:8,14 51:21
away [10] 133:7 221:3 226:12 Bcl-X [3] 129:15 130:6,11 15 38:14 48:19 56:20 58:10 155:1 181:1 210:7
283:17,18 284:9,19 297:7 Bcl-XL [2] 129:7,22 64:5 65:2 87:3 94:2 98:6 101: blood [28] 57:9 58:2 85:21 90:
307:9 321:12 BDNF [4] 299:10,12,15,19 9 115:10 116:5 117:16 144:9 4 91:20 92:6,9 94:4 99:13,20
axis [1] 317:9 BDNF-dependent [1] 300:9 149:20 154:21 158:3,16 160: 103:22 105:17 120:5,14 121:
Aynsley [1] 316:10 beautiful [1] 100:19 6 162:13,16,17 163:16 166: 2,3,8,19 122:1 137:8,11 149:
became [2] 226:14 251:9 20 169:3 179:7 181:21 207:9 16 168:3,5 190:3 253:22 257:
B become [9] 35:13 71:13 79:4 208:20 228:9 237:4 247:6,19 11,11
babies [13] 28:19 109:2 140:4 225:17 226:18 250:8 293:4 262:4 274:18 282:19 283:5 blood-gas [1] 119:22
187:19 213:4 272:12,20 285: 320:7 326:12 286:3 293:13 324:18 341:16 blotting [1] 79:11
9 308:19 317:2,4,6 331:22 becomes [6] 79:7 121:3 253: 346:12 347:2 blue [1] 170:4
baby [5] 20:22,22 203:2 283: 6 278:22 287:5 359:11 beyond [1] 142:6 blueprint [1] 241:1
17 301:22 becoming [2] 66:19 213:21 bicarbonate [1] 137:7 blunting [1] 201:19
BACE [2] 237:21 238:16 beer [2] 226:11 229:2 BID [1] 227:20 Bob [6] 2:30 3:8 5:9 300:12
back [29] 34:15 80:1 100:19 beg [1] 224:5 big [5] 121:4 263:20 308:17 311:2 365:7
133:7 141:6 144:6 147:9 163: began [4] 28:2 149:11 164:10, 320:1 326:4 bodies [1] 115:11
14 169:22 184:1 194:14 206: 17 biggest [2] 104:5 146:1 body [4] 15:5 17:15 57:18
16 227:15 238:9,19 284:18 begin [7] 13:15 74:19 147:10 bilateral [1] 124:12 245:3
286:5 287:15 296:7 303:13 182:19 204:19 296:8 359:16 bilaterally [1] 80:14 Bohnen's [1] 246:2
316:7 322:22 330:2 332:9 beginning [8] 65:12 66:18 78: Bill [6] 99:15 203:12,12,14,21 bolster [1] 317:13
339:22 357:7,19 358:1,10 12 94:22 112:17 218:15 219: 340:3 bolus [2] 135:20 340:22
Background [4] 3:7 10:22 3,7 binges [1] 105:17 booth [2] 315:9,13
227:4 230:13 begun [2] 166:19 181:13 bioinformatics [2] 314:19, born [4] 19:22 28:19 111:7
bad [8] 36:5 138:20 183:18 behalf [1] 9:19 22 112:20
201:15 232:19 285:1 304:14 behavior [5] 17:13 209:7 210: biological [4] 30:7 31:19 32: borrowed [2] 42:22 48:8
355:18 16 290:17 356:14 16 138:11 Boston [6] 7:15 185:11 197:
Bailey [1] 345:21 behavioral [32] 11:20 19:21 biologist [1] 220:7 11 200:16 250:8 303:10
Bakersfield [1] 4:10 47:16 54:16 63:5,9 67:11 biomarker [4] 180:17 229:22 both [46] 19:18 22:12 26:22
balance [2] 117:15 324:18 106:13 107:16 125:16 142:2 271:1,3 31:3 33:22 36:2 40:14 44:20
balancing [1] 116:5 144:18 145:17 165:13,16 biomarkers [8] 106:10,12 61:3 62:7 66:14 69:21 76:19
ballot [1] 315:14 208:8,11 209:12 210:22 268: 165:20 289:2,14,18 292:21 83:20 93:7 99:1,10 117:3
balls [2] 78:21 115:5 17 275:21 282:4 283:14 285: 299:3 148:11 166:1 169:8 172:1
banana-flavored [1] 291:4 7,15 290:8,10,21 291:3 323:7 biopental [1] 319:14 177:15,18 185:19 197:22
band [1] 172:19 346:11 359:4 Biostatistics [1] 8:1 198:14 218:7 232:16 238:16
barbiturates [4] 83:17 194:5 behavioral-affected [1] 343: biphasic [1] 337:11 241:15 242:6 246:10 263:12
319:14 328:22 10 bipivacaine [1] 282:2 265:14 266:9 267:5 278:10
barely [1] 133:3 behaviorally [1] 125:21 birth [19] 17:5 28:19 48:18 76: 290:19 291:6 292:2 295:1
bars [1] 170:8 behind [1] 215:2 4,6,7 110:12,16 162:17 164: 325:22 330:7 356:21 358:9
base [8] 13:11 15:3 57:18 belief [1] 351:20 15,16 185:18 192:10,17 193: bottom [4] 19:18 34:3 74:15
297:22 302:21 353:6,6 364:8 believe [32] 15:10 36:6 49:6 5 241:17 256:12 314:17 332: 262:21
Based [36] 9:11 24:17 25:17 70:18 86:17 89:22 92:10 93: 8 bought [1] 250:4
26:8,20 42:10 44:12 46:12 13 102:18 110:4 111:6 112: births [1] 109:1 box [4] 171:8 284:10 297:7,7
48:15 66:13 68:2 69:5,10 73: 10,16,22 157:22 202:1 214: BIS [3] 252:19 253:14 255:22 boxing [1] 321:12
9 101:22 115:20 126:6 129:6 17 218:8 240:1 242:7 245:3 bit [29] 22:12 39:2 48:4 106:5 boy [1] 220:10
146:9 160:22 161:11 162:21 248:13 249:7 259:19 265:14 111:6 120:11 131:8 132:10, BPCA [1] 328:2
163:1,7 172:11 204:17 205: 272:15 280:18 286:2 305:1 11 139:3 143:20 152:20 170: bracket [1] 204:19
17 207:9 230:20 268:17 302: 313:5 329:21 334:13 13 171:1,17 176:1 177:19 Brad [1] 275:3
11 305:12 308:21 310:13 believed [2] 112:15 241:2 184:1 212:22 216:14 230:14 bradycardia [1] 185:7
347:10 359:6 believes [1] 218:12 232:8 252:10 267:12 274:1 brain [116] 11:13 12:20 16:21
baseline [1] 122:1 beneficial [3] 72:17 97:17 299:13 341:5 343:12 345:15 17:21 41:17 42:14 43:5,15,
basic [5] 126:7 206:16 266:9 305:10 black [1] 94:10 18,22 46:3 50:5,8,20 51:2,5
298:7 330:7 benefit [4] 21:5,12 27:2 33:19 blank [1] 76:12 55:12 69:7 76:1 77:4,6,11,19
basically [15] 84:2 108:22 benefits [7] 21:14 25:22 26: blebbing [1] 18:11 78:3 80:10,15,20,22 81:13,17
110:10,20 111:9 113:14 120: 11 251:17,20 254:18 255:19 blind [2] 285:18,19 82:12 90:18 94:8,17,19 95:8
8 126:21 183:16 184:15,22 benign [1] 242:19 block [19] 67:22 71:8 75:18 97:4 101:12,15,18,22 102:2,
202:5 230:11 250:10 258:6 benzodiazepine [1] 208:11 107:7 154:17 155:1,17,19 15 107:10 110:15,17,17 111:
basis [12] 29:20 164:20 167: benzodiazepines [4] 83:17 156:6,11 157:12 161:6 178:4, 1,2,3,9 112:18,21 115:22 118:
17 195:16 207:11 212:21 84:9 194:5,22 5 181:5 186:18 246:21 279: 19 119:10,14,18 134:7 136:8,
240:6 270:2 305:22 325:17
brain - changes

12 140:5,16 145:20 150:7 282:15 348:19 13 233:16,16,19 235:15 236: 81:1 82:1 124:3 139:9 150:9
153:1,3 163:8 173:9 183:13 calling [3] 113:19 135:11 229: 13 237:9,12,17,18 238:20 153:20 154:5,18,19 155:22
188:18 192:21 194:8,15 195: 11 257:18 258:7 300:14 156:3,8,18,18,22 157:22 158:
22 196:2 235:12 244:1 256: calls [1] 305:8 caspase-3 [29] 79:20 80:3,6, 6,15,21 159:6 160:18 161:16
20 257:5,17,17 259:6 261:8, Cambridge [1] 348:19 12,19 90:20 129:11,17 131: 171:7,17 172:19,20 173:9
11 263:8,12,15 264:3 265:14, came [12] 76:12 122:21 132: 16,19 132:8 137:22 138:3,6, 204:11 236:7 238:8 240:13
15 269:3,5 272:11 275:22 14 157:3 163:19 186:13 225: 13 139:5,15 167:4 171:5 172: 246:13 262:20 263:5 265:1
279:22 282:17,21,22 294:21 14 266:15 286:4 314:4 358:1, 3,12 175:12,20 236:8,16 238: cellular [1] 240:15
299:11 305:16 314:15 321: 10 14 258:5 299:17 321:18 cellularity [1] 269:9
17 323:21 324:1,3,9,10,13,15, cancel [1] 100:22 caspase-3-positive [1] 94: CENTER [18] 1:3,9 5:15 7:10
20 338:2 340:2 359:8 361:7 cancer [9] 220:16 223:6 225: 11 9:14 12:1,2 30:5 44:20,22 48:
brain-growth [1] 17:1 19 227:16 228:1 245:7 246: caspase-8 [4] 131:15,19 132: 2 65:16 147:16 200:17 249:
brain-tissue [1] 152:21 10 247:1 274:5 5 299:7 16,17 251:9,12
brains [6] 35:17 76:21 94:18 candy [1] 134:12 caspase-9 [6] 79:20 129:10, Center,Walnut [1] 4:14
104:20 167:1 171:14 cannabinoid [1] 107:17 16 131:6,7 299:17 centers [1] 351:15
Branch [3] 8:12 45:2 325:9 cannot [23] 20:21 25:13 26: caspase-positive [2] 95:21 central [3] 110:10,11 240:8
break [11] 14:11 147:6,8,11 15 36:13 40:9 95:22 98:16 96:17 ceramide [1] 300:3
179:4 203:6 216:21 326:6 104:16 114:6 122:16,16 140: caspase-stained [1] 139:9 cerebellum [1] 95:15
333:2,3,6 16 210:15 211:18 212:12 cast [1] 315:14 cerebral [7] 121:8,16,19 122:
breast [1] 247:1 268:5 270:1 284:15 286:1 categories [3] 20:19 24:17 1 260:5,5,8
breath [1] 190:2 287:7 297:20 298:1 356:1 166:1 certain [13] 17:17 21:6 38:19
breathing [1] 254:20 cannulation [1] 91:10 Category [13] 24:19 25:3,17 94:5 101:20 117:21 125:22
bridge [1] 249:19 CANTAB [2] 348:19 363:2 26:2,5,7,17 27:5,9,10 286:14 160:15 278:20 289:12,17
brief [2] 13:16 350:17 capable [1] 19:15 296:9,10 292:3 299:7
briefly [3] 126:2 128:20 224: capacity [1] 360:20 Cathy [3] 2:3 3:5 6:17 certainly [75] 46:18 56:19 64:
22 Capillary [1] 240:5 caudal [1] 278:8 7 70:11,12 71:21 72:10 109:
Brigham [1] 4:19 captured [1] 37:9 caudate [4] 87:13 88:8 94:9 7,11 112:8 120:16 121:2 133:
bright [1] 228:20 card [2] 237:2 263:8 96:15 5 134:1 140:21 148:7 149:9
bring [8] 15:10 144:6 161:17 Cardiac [5] 185:22 186:6 247: causal [1] 347:3 156:9 159:14 160:21 162:18
284:17 323:17 330:15,17 14 291:17 346:5 causative [1] 344:7 167:13 169:11 173:4 175:16
357:16 cardiologist [1] 346:1 cause [15] 75:6 85:21 86:8 87: 178:3 179:6,15 181:1,6 183:
bringing [3] 89:1 208:2 227:3 cardiovascular [2] 282:15 20 90:13 91:6,7 123:7 213: 21 186:14 187:13 189:6,10
brings [3] 266:18 333:2 364:2 301:4 19 239:1 242:2,4 302:14 305: 190:8,16 192:6,14,22 193:11,
British [1] 316:12 Care [32] 7:17 102:10 189:22 15 355:9 19 194:17 196:3 198:12 199:
broad [3] 101:19 193:3 248: 197:4 201:18 213:3 249:10 caused [7] 28:18 76:18 79:16 9 201:16,20 226:6 229:20
15 256:13 283:9 284:22 291:15 89:4 145:18 193:18 283:6 271:21 279:12 286:18 291:
broaden [1] 261:6 298:20 301:13,15,22 302:3,8 causes [6] 79:18,19 88:7 232: 22 292:15,17 293:6,15 294:6,
broader [1] 339:17 303:10,17 304:17 305:19,21 18 257:1 297:10 11 295:20 298:6,10,19 302:
bronchoscopy [1] 72:4 306:3,14 307:7 310:15 322:4 causing [3] 56:15 82:12 194: 13 320:7 329:8 332:17 343:
bronchospasm [1] 109:19 330:22 331:4 354:17 364:1 7 12 346:18 356:16 361:9,15
brought [11] 168:4 208:18 365:3 caution [3] 101:8 102:3,9 362:14 364:6
225:16 269:13 284:17 289:1 cared [1] 224:1 cautioned [1] 204:21 cervical [1] 278:9
308:4 324:6 328:2 330:22 careful [2] 10:18 359:1 CBER [1] 182:9 cesarean [5] 21:17 94:6 95:7
335:3 carefully [9] 121:19 151:9 CDER [8] 12:6 47:1 149:14,20 350:18 352:16
bulk [1] 141:9 223:8 292:8 317:15 324:5 182:8,11 198:16 325:20 cetera [3] 205:2,2 215:5
bupinorphine [1] 225:22 341:19 354:22 359:13 CDER's [1] 45:1 Chahal [1] 269:5
burn [1] 303:13 cares [1] 125:3 CDER/NCTR [2] 3:20 147:17 chain [1] 98:9
burns [1] 303:9 carotid [1] 91:10 cell [75] 18:5,7,8,13 50:9 73: Chair [8] 2:2 6:8 8:6,16,18
business [2] 5:6 211:22 carried [1] 31:15 14 77:15 78:20 79:2,6,21,22 168:20 218:5 253:10
busy [1] 16:1 carry [1] 314:10 80:3,4,7,7 87:11,14 90:22 chaired [1] 281:19
button [1] 311:16 cartoon [1] 98:2 107:2 114:1,2,22 123:22 130: chairs [1] 168:20
bypass [1] 331:11 cascade [3] 98:12 240:8 300: 9 139:16 149:2 153:17 154:9 challenge [5] 67:22 99:1 208:
2 155:10,14 156:5,10 157:5,8 6 277:5 308:8
C case [29] 42:17 60:3,6 73:1 158:1 160:16 161:15,18,22 challenges [5] 55:17 56:22
C57BL/6 [1] 86:1
93:21 105:14 123:15 130:15 162:6 167:3 171:8 172:8,11, 58:7,19 72:15
CA1 [1] 258:1 135:21 139:20 153:18 166: 16 173:7 174:8 175:14 176: challenging [2] 51:17 57:6
cage [1] 91:19 15 188:2 194:8 207:1 231:11 21 177:17,22 180:18 205:8, chamber [1] 284:12
cake [4] 98:17,22 99:4 107:5 232:11 262:11 283:18 284:5 11 231:17,21 236:8,11,13 chance [1] 147:21
calcium [7] 149:2 161:15,18 289:19 298:4 302:2 305:9 237:10 240:14 241:11,15,22 change [12] 137:21 196:5
162:2,6 176:20 177:4 344:4 349:22 355:22 365:5, 263:11 269:3,22,22 270:2 204:14 223:4 260:10 263:19
calibrate [2] 205:21 318:7 20 277:3 299:1 338:5,10 339:10 268:2,3,5,6 273:22 313:11
calibration [1] 328:10 case-control [1] 246:7 cell-based [1] 240:11 changed [4] 183:22 304:22
California [6] 4:10,15 228:20 cases [13] 24:3 140:13 141:9, cell-culture [3] 156:21 262: 305:20 306:1
239:21 248:8 249:17 10 190:19 249:20 251:13 22 287:20 changes [37] 11:19,20 27:21
Call [7] 3:2 5:2,3 111:5 118: 252:17 292:6 294:9 307:12, cell-death [4] 152:7 154:4 35:16 42:14 67:11 78:12,13
16 222:5 239:16 14 347:14 157:5 161:1 115:2 119:1 121:15 122:2
called [10] 31:2 42:10 113:17 caspase [18] 95:11 96:6,9,11, cells [39] 18:10,12,17 80:22 124:20 129:6 142:13 143:11,
127:2 128:2 167:6 237:21,21
changes - comparable

15 144:18 168:5 188:20 189: circuitry [3] 17:22 185:15,19clumped [1] 78:21 337:1,3 341:6,19 342:7
1 192:6 194:10 235:6 237:10 circulation [5] 62:17,22 196:clumping [2] 115:3 213:10 combine [1] 212:21
244:18 266:7 268:15 274:14, 5,6 350:10 CNS [3] 12:21 327:16 350:13 combined [4] 61:12 81:10
19,21 293:7 299:6,14 303:14 circulatory [1] 346:5 co-authored [1] 53:5 118:14 303:21
343:8 360:21 circumcision [1] 22:2 CO-oximeter [1] 168:10 combining [3] 70:1 209:10
changing [2] 108:16 304:10 circumstances [8] 55:20 56: CO2 [2] 137:10 253:18 335:3
channel [16] 82:21,22 83:21 4,10 75:4,13 221:8 279:17 Coagulation [1] 240:8 come [27] 97:9 106:4 116:13
210:13 279:16,18 280:1,15, 304:3 coal [2] 225:11,14 121:5 133:7 135:10 141:4
18,20 281:3,4,9,13 327:8,10 cited [1] 358:16 cocaine-exposed [1] 276: 170:5 194:14 226:20,21 231:
channels [1] 281:7 Citizen [1] 222:16 21 10 237:14,14 238:8,19 303:
chapter [1] 358:15 clarification [1] 341:5 cocktail [10] 55:11 84:21 88: 13 315:2 321:1,9 327:18 331:
characterize [5] 41:16,20 45: clarified [1] 208:16 12,22 118:17 123:7 129:14, 2 332:9 349:14 352:16,20
4 47:13 341:8 clarify [2] 71:19 208:4 20 142:21 209:13 353:1
characterized [2] 18:10 331: Clark [1] 300:12 cocktails [2] 84:18 212:16 comedications [1] 37:21
15 class [5] 320:22 322:11 331: cocky [1] 108:12 comes [12] 104:13 109:17
Charles [4] 2:14 4:5,6 9:17 21 357:9,10 Code [2] 24:15 260:10 155:8,14 170:8 237:7 273:16
Charley [1] 8:20 classes [4] 30:12 76:17 82: Coexisting [1] 196:22 275:20 282:18 306:10 347:9,
Charlottesville [1] 6:15 15 83:4 cognition [3] 128:13 230:6 16
chart [3] 27:21 191:17 359:14 classic [2] 164:19 167:3 237:1 comfort [5] 35:4 234:7 255:
check [2] 253:17 263:20 classical [2] 79:7 172:15 cognitive [46] 17:12 19:21 16 304:7 330:16
chemical [3] 184:16 250:22 classification [1] 297:17 119:5 125:22 140:22 141:2 comfortable [4] 57:20 245:
251:3 classifications [1] 38:20 144:10,17 146:12 165:12 20 304:2,2
chemicals [1] 30:7 classified [1] 301:5 180:6 211:4,6,8,17 212:14 coming [14] 9:8 11:3 65:16
Chemistry [2] 230:16 250:21 classifying [1] 24:16 213:19 214:1 232:5,18,22 66:16 74:5 134:2 168:1 170:
chemotherapy [1] 274:4 clean [1] 210:11 233:3,14 237:3 261:17 262:4, 11 235:6 286:12 289:2 300:
Cheng [2] 157:2 182:5 cleaning [1] 251:2 11 263:22 264:19 265:22 12 314:20 362:18
Chicago [1] 220:8 clear [18] 32:13 44:16 45:22 266:4,7 267:7 275:8,19,21 commen [1] 353:17
Chief [2] 7:6 8:7 48:16 58:1,14 66:19 68:3,8 290:14 291:8 301:1 330:4 comment [26] 10:13 38:1
child [16] 71:22 72:3,3 109:8 71:8,11,17 228:11 242:4 278: 352:12 354:21 355:10,13 100:1 201:5 207:22 208:1,7
141:13 192:20 211:15,20 14 300:20 302:15 312:15 358:13 359:4 229:8 269:10 270:1 281:19
276:1,2 286:22 302:8,19 307: clearance [2] 214:16 215:3 cognitive-function [1] 289: 282:9,10 292:20 295:1 326:
22 318:14 360:1 cleared [1] 81:22 9 16 331:13 333:20 334:9 335:
child's [1] 192:21 clearing [1] 110:3 cognizant [5] 109:22 287:12 14 336:18 337:14 344:20
child-bearing [1] 31:4 clearly [16] 13:1 25:16 27:1 306:6 308:3,17 348:4 350:3 356:10
childhood [2] 106:6 348:13 150:3 221:5 228:14,18 232: Cohen [1] 248:7 comments [5] 222:2 327:5
children [55] 15:16 19:22 20: 18 280:3 313:8,22 314:17 cohort [5] 199:11 343:13,18, 333:18 341:1 365:19
5 28:7 31:16,21 32:6,7,12 35: 316:5 324:1,14 331:22 20 363:11 commercial [3] 83:2,5 84:4
16 36:5 44:15 72:1 109:4,15 Clinic [7] 4:5 142:6 180:20 coincides [2] 75:22 123:5 commit [2] 74:20 75:3
110:3 141:7 144:19 145:9 246:2 317:12 358:2,10 Coleman [4] 4:10 239:19,20 commitment [2] 33:6 79:22
146:20 208:8 220:10 222:21 Clinical [75] 3:24 7:19 8:3,11 243:12 committed [3] 80:4,7 139:16
253:5 255:3 264:13 267:3 11:11 13:13 14:21 15:1,3,7 collaboration [1] 42:5 COMMITTEE [31] 1:5 2:5,13
271:11,17 275:5 276:3,19,20 30:22 31:5 32:15 33:14 37:7 collaborations [2] 200:17 4:20 5:5 8:18,22 9:9,12,21
290:20 291:3,6 301:13,16 40:14 41:21 44:14 55:5 57:4, 272:3 11:2 16:11 45:11 182:18 218:
302:7 308:10,13,17 316:8,17 8,15 68:3 117:22 120:17 140: collaborative [2] 12:3 200: 11,17 219:4,22 224:21 225:5
322:4 327:14,19 330:18,21 20 145:3 167:15 180:14 183: 12 243:6,19 248:14 261:4 267:4
346:19,22 347:5 348:6 362: 1,3,10 188:7 206:1,2,4 213:8, colleague [3] 157:2 184:19 316:3 326:13 332:18,22 334:
19 364:20 13,18 234:4 236:5 244:3,8,20 302:1 17 335:1
Children's [7] 7:14,20 8:8 245:21 246:11,19 248:20 colleagues [9] 11:5 101:22 common [6] 106:18 109:11
185:11 197:11 306:2 328:3 249:9 261:15 266:10 271:4,6 149:14 182:6 228:4 254:2 221:11 234:22 327:15 353:6
chloral [1] 23:5 272:14 286:8 297:22 298:20 306:2 322:19 351:22 commonly [11] 19:6 67:15
choice [3] 260:20 352:2 355: 313:11 320:12 322:6 325:2,5, collected [4] 19:8 120:4 157: 109:15 117:12,19 125:10
19 6 330:2,3,7 333:12 335:4 1 268:12 135:14 187:4 213:12 236:2
choose [3] 219:6 302:11 304: 342:14 343:2 351:4 358:1 collecting [1] 36:19 238:13
10 359:1 361:8 362:4 collection [1] 201:6 communication [1] 361:10
choosing [1] 298:16 clinically [11] 42:11 60:5 118: college [2] 220:14 228:20 communities [1] 15:13
CHOP [1] 351:16 7,9 125:11 188:2 212:17 215: Colorado [1] 6:9 community [7] 15:15 198:13
chose [1] 287:1 15 279:18 307:4 321:5 combination [36] 61:13 62:6, 199:8 200:10 202:9 248:4
Chou [1] 228:4 clinicians [3] 23:2 37:3 202: 12 63:16,19 67:14 69:21 85: 325:21
chromatin [3] 78:22 115:4,5 16 15 87:19,20 103:2,4 118:20 comorbidities [2] 37:21 245:
chronic [3] 223:5 225:21 279: close [7] 37:6 133:9 152:17, 119:12 121:18 123:16 124:2 12
4 22 210:19 266:19 364:10 137:17 138:5,21 140:2 220: comorbidity [2] 248:1,18
chronically [3] 189:12 279: closed [1] 255:8 21 221:2 231:20 246:16,20 companies [1] 250:6
11 286:15 closely [7] 57:4 146:4 195:5 263:4 268:10 296:12 299:12 company [4] 10:1 234:20
Chrysanthy [1] 11:4 236:22 241:4 248:17 285:8 334:19,21 335:22 336:3,4 243:22 256:10
cingulate [2] 124:6,11 closer [3] 142:22 152:20 198: 341:17 comparability [1] 162:15
circ [1] 331:11 10 combinations [11] 70:15 comparable [6] 95:22 99:15
circuitries [1] 111:17 closing [1] 223:22 103:6,8,12 240:14 334:11 101:20 227:15,22 228:2
comparative - couldn't

comparative [1] 275:4 10,10,12 328:11 340:6 342: conjunction [1] 149:13 81:4 242:3 289:20
compare [14] 82:8 122:16 20 350:9,14 351:1 353:3 connect [1] 116:7 contribute [3] 52:21 58:4
132:10 138:4,18 165:22 198: concept [4] 64:7 142:15 174: connected [1] 142:13 197:6
6 214:1 215:6 289:19 296:21 2 288:17 connection [1] 218:22 contributed [3] 13:10,12 45:
297:13 327:10 328:18 concepts [1] 248:2 connections [1] 111:16 15
compared [24] 53:11 59:10, conceptual [2] 74:18 75:11 consciousness [1] 254:16 contributing [2] 339:7 342:5
12 92:6 121:22 122:12,20 conceptualization [1] 145:8 consecutively [1] 251:14 control [63] 30:12 57:9 80:22
127:11 132:1 135:21 139:9 concern [10] 16:19 20:8 146: consensus [2] 332:18 365:1 91:21 92:1,6 94:13,14 95:10
140:13 150:12 158:21 171:6 16 246:7 272:8 273:15 302:7, consent [1] 29:15 96:1,12,16 122:18,21 124:7,8,
172:5,17 233:20 247:12 272: 10 323:18 363:14 consequence [1] 204:2 9 127:3,17,20 128:9 130:1,19
16 282:2 318:12 323:7 343: concerned [11] 212:1,8 213: consequences [7] 186:22 140:14 142:7 149:1 152:5
15 8 216:14 222:15 253:2 301: 187:6 229:2 244:9,13 245:1, 154:6 156:2 157:13 158:21
compares [2] 71:10 296:6 17 304:5,6 327:7 339:18 8 159:4,18 168:15,17,21 169:4,
comparing [5] 60:4,10 66:5 concerning [4] 12:1,17 100: conserved [1] 17:3 5,8 171:6,9,18 172:5,9,17
69:19 160:6 2 145:6 consider [25] 14:1 22:16 24: 173:8,16 174:5,22 176:7 182:
comparison [5] 101:9 133: concerns [14] 11:10 14:20 14 109:7 113:19 182:2 193:2 1 198:2 199:15 232:15 233:9
16 207:9,11 273:2 33:18 44:14 71:20 183:16 196:3,19 201:17 222:4 231:6 240:10 242:14 262:13 284:4
comparisons [3] 57:19 106: 244:5,7 249:9 266:16 276:15 233:10 245:11 251:7 264:3 292:4,7 294:11 304:7
5 112:3 302:3 303:22 313:4 279:20 297:18 306:20 316:4 controlled [8] 114:12 137:12
compassionate [1] 223:22 conclude [1] 224:12 317:15 318:19 336:13 339:5 139:5 199:10 227:22 343:21
compelling [4] 254:18 265: concluded [3] 220:20 227:19 352:9 350:7 362:18
15 306:12,13 228:7 considerable [1] 46:12 controlling [1] 301:18
compensatory [3] 130:8 162: conclusion [4] 123:9 239:5, consideration [8] 56:18 70: controls [21] 94:15 122:14
4 212:3 13 264:15 14 72:12 205:14 222:14 243: 125:20 127:11,16 132:10
competitive [1] 325:17 conclusions [5] 93:10 96:21 6 245:10 329:10 135:6,8,10,11,12 138:5 139:
competitors [1] 218:19 145:13,14 255:12 considerations [1] 364:14 10,22 150:13 160:8 211:3,14
complete [2] 241:13 318:4 concomitant [3] 321:3 329: considered [10] 108:15 113: 223:7 232:16 286:3
completed [2] 48:1 200:4 15,17 15 205:1,9,22 259:14 271:16 conundrum [1] 249:4
completely [8] 69:9 112:19 concomitantly [1] 335:9 292:10 319:2 361:16 conversation [1] 345:13
128:4 145:10 187:11 286:2 concurrent [3] 57:7 282:13 considering [7] 125:9 229: conversations [1] 363:14
317:8 342:18 329:18 20 242:6 249:4 256:5 261:4 convince [1] 261:9
completes [1] 241:5 condensation [1] 174:6 283:7 convinced [1] 325:3
complex [7] 126:19,22 128:2 condensed [1] 79:7 consist [1] 29:8 convincing [1] 288:5
165:16 180:6 212:5 354:21 condition [4] 85:9 92:8 102:8 consisted [3] 42:18 44:19 54: cooling [2] 292:12,12
compliant [1] 124:21 196:8 14 Coordinating [1] 45:11
complicated [1] 339:3 conditioned [3] 62:18 63:1 consistent [9] 157:9,18 160: cord [9] 278:4,5,8,9,11 280:2,
complicating [1] 292:4 168:20 8 174:10 176:17 177:1,2 343: 19,21 329:7
complication [1] 252:12 conditions [17] 17:11 18:8 9,10 core [1] 196:16
complications [5] 109:11,14 20:21 21:6 25:18 54:1 85:2,8 consistently [1] 216:16 coroner [1] 220:20
199:1 245:8 277:2 90:11,12,13 92:2 187:14 205: console [1] 220:15 correct [11] 68:22 69:1 157:
component [2] 155:18 275: 1 291:20 292:17 293:8 constantly [2] 283:21 284:3 14,15 202:13 219:20 295:13
14 conduct [6] 31:20 32:15 196: constructive [1] 97:10 334:7 339:4 353:22 363:18
components [1] 148:17 4,19 202:18 255:17 consultant [1] 7:1 corrected [1] 322:14
composed [2] 45:12 184:13 conducted [16] 19:9 23:22 consumed [3] 20:1 220:18 correctly [3] 70:17 206:1 280:
compound [4] 215:3 228:11 24:21 32:11 33:2 41:13 42: 222:22 16
279:12 341:14 16 48:15 61:6,11 64:15 66:3, consumer [1] 265:6 correlate [2] 49:3 104:17
compounding [1] 344:13 17 70:10 220:20 247:18 consumption [1] 20:3 correlated [3] 106:12 275:8
compounds [17] 17:20 47:8 conducting [2] 59:2 68:11 contact [1] 37:6 349:3
49:21 50:8 52:2 54:12 55:1,7 conduction [1] 47:20 contain [3] 23:12,18 24:10 correlation [4] 103:10 105:9
61:19 62:2 64:9 67:1,4 238:3 confident [4] 290:20 345:17, containing [2] 28:5 221:20 136:10 247:6
341:16,21 342:4 18 357:3 contains [2] 19:2 22:18 corresponding [1] 17:6
comprehend [1] 127:11 confirm [4] 59:7 119:20 139: content [1] 102:1 cortex [25] 88:8 95:9 96:3
comprehensive [2] 208:5 19 145:16 context [4] 218:13 281:3 294: 121:13 122:22 124:6,12 130:
222:9 confirmation [1] 12:4 3 358:5 10,16,22 132:3,6 139:7 153:
compressed [1] 92:19 confirmed [2] 46:8 53:19 continue [10] 14:11 202:22 18 156:14,22 171:22 172:1
compromised [1] 273:10 confirming [1] 60:17 221:17 244:17,20 248:12 193:17,17 258:1 267:19 276:
concentrated [2] 81:5,5 Conflict [8] 3:4 9:1,3,5,15,16 287:11 316:1 341:15 364:14 8 278:8 299:15
concentration [19] 88:13,16, 239:21 243:21 Continued [2] 4:1 332:13 cortical [7] 101:15 121:7,16
20 89:3,6,8,11 99:11 100:4 conflicts [1] 230:2 continues [1] 32:8 124:13 138:3 267:10 269:7
103:22 159:8 207:10 236:6 confounded [1] 354:9 Continuing [1] 318:1 cortices [1] 123:2
257:12 319:12 335:19 352:3 confounding [5] 196:20 199: continuous [7] 134:16 167: cortisol [1] 317:11
355:4,20 11 287:3 288:1 344:3 17 188:22 340:15,18,20 347: Cosmetic [1] 28:11
concentrations [28] 58:13 congenital [4] 21:10 195:18 20 cost [1] 101:5
100:12,14 118:14 125:13 331:8 332:6 Contra [1] 249:18 Costa [1] 249:18
152:21 157:9 169:20 203:20 conglomeration [1] 191:18 contracted [1] 29:17 coughing [1] 252:10
205:21 206:8 214:12,14 279: Congress [2] 28:10 325:18 Contrary [1] 257:20 couldn't [6] 125:19 133:18
22 280:4 295:18 296:1 318:8, Congressman [1] 219:19 contrast [6] 43:19 50:2 52:1 209:17,18 210:8 215:1
coumadin - demonstrated

coumadin [1] 241:19 currently [11] 11:16 48:1 82: 334:15 337:21 338:1 342:8 decline [3] 232:18,22 233:14
Council [1] 29:18 16 93:4 116:15 135:5 235:7 343:12 356:12,16,17 declines [1] 242:2
count [1] 311:11 291:11 319:21 339:15 348: Database [13] 36:21 37:1,19 decrease [11] 70:7 82:6,10
counted [2] 311:8 317:3 17 38:5,14 39:18 40:3 199:2 129:15 130:6,12 238:4 274:
counting [1] 282:5 Curtis [1] 227:16 247:9 267:1 309:6,8 318:4 13 300:3 321:3,15
country [1] 326:5 curve [9] 100:8 167:19 191: databases [1] 291:2 decreased [4] 104:15 140:12
county [3] 221:12 249:18,18 11 203:19 246:6 319:11 335: date [7] 12:21 14:6 19:7 71: 299:19 331:20
couple [11] 96:12 106:4 112: 20 340:9 353:11 14 309:17 311:12 341:6 decreases [1] 274:15
11 161:10 189:22 251:13 curves [3] 328:17 342:7,11 daughter [1] 220:12 decreasing [1] 180:22
262:12 281:21 324:22 353:2 cut [3] 82:6 219:13 345:12 daughter's [2] 221:20 224:5 decrement [1] 346:10
359:18 cutting [1] 81:13 Dave [4] 125:14 209:5 254:9 dedicated [1] 225:6
course [40] 54:6 81:10 96:21 cycle [4] 236:18 238:10,21 335:2 deep [10] 95:12 96:6,8,8 186:
109:5 121:20 132:9 135:20 239:9 David [2] 2:11 7:8 2 190:9,11 247:20 252:10
138:15 146:17 149:1,7 151:8 cyclopropane [1] 143:7 Davidson [1] 200:15 346:5
155:21 157:13,16 158:19 cystic [1] 21:10 Davis [2] 228:22 249:1 deeper [1] 339:14
161:3,17 168:11,17 169:20, cytochrome [9] 79:18 129:9, day [42] 53:7 59:10 61:12 62: defect [1] 347:16
20 171:10 177:4 178:22 180: 16 130:9,14,15,17,21 131:1 21 63:3 65:7 66:2,2,5 93:22 defective [2] 17:21 18:17
4,21 190:16 196:4 204:10 cytokine [1] 299:2 110:10 127:9 150:2 157:1 defects [2] 28:19 256:12
215:19 252:12 254:10 279:8 cytoplasm [4] 78:11,13 79:6 162:19 166:9,10,11 169:7 defer [1] 73:17
285:5 294:5 318:6 334:20 115:10 172:7 175:17,19,22 176:2 deficit [2] 105:22 211:4
340:20 358:1 cytotoxicity [1] 232:1 178:10,10,12 179:16 215:11 deficits [18] 55:12 62:9 63:5
courses [1] 329:2 216:6 220:14 258:4 285:8,10, 104:8,11,14 105:6,11,22 196:
Court [2] 30:10 31:21
D 19,19 301:21 314:5,17 333:5 18 198:9 213:19 263:15 266:
cover [2] 36:7 327:1 D-aspartate [1] 18:3 362:10,10 5 290:21 296:19 301:2 355:
coworkers [2] 74:12 149:9 daily [4] 117:20 285:9 305:22 day-35 [3] 169:9 170:13 172: 13
craniofacial [1] 105:7 327:4 9 define [3] 100:3,6 351:10
create [1] 283:1 damage [22] 107:8 122:13 day-5 [2] 170:10 171:18 defined [3] 86:5 290:11 337:9
created [1] 113:16 123:8 124:19 125:3,7 146:3, days [46] 17:4 54:16 65:4 81: defining [5] 178:13 181:16
creating [1] 118:16 8 193:18 267:17,20 268:20 21 94:1 105:18 112:18,20 293:20 359:5 360:11
Creek [2] 4:14 249:17 272:20 273:7 275:18 278:15 113:3,7,8 118:22 121:22 123: definitely [4] 96:17 347:12,19
Crile's [1] 242:11 279:12 297:11 302:4,14 305: 5 125:18 127:6,8,13,14,18,19 348:3
crisis [1] 225:8 15 362:13 134:22 140:4 153:21 162:18 definition [2] 73:13 100:9
criteria [2] 258:15 353:7 damaged [2] 76:21 140:9 164:14,15,16 184:11 189:5,5, definitive [5] 15:9 97:7 273:1,
criterion [1] 232:12 dampened [1] 170:22 6 192:8,13 193:4 206:4 211: 8 347:10
Critical [18] 7:17 37:11 49:11 Dan [5] 3:14 5:18 7:22 41:4 12 214:11 220:13 268:13 degenerating [1] 81:2
63:7 149:3 159:16 161:5 167: 72:20 271:12 273:19 285:20 321: degeneration [8] 51:1,14 77:
9 169:21 205:7 237:2 255:4 danger [1] 221:10 16 347:17 353:2 20 78:1,5 81:10 102:17 278:
256:13 292:2 324:9 330:22 dangerous [3] 221:9 278:22 de [2] 2:10 3:26 7
331:4 360:6 318:16 deactivation [1] 338:21 degenerative [2] 81:22 95:
critically [1] 286:15 Daniel [4] 2:17,24,32 14:4 dead [3] 123:21 124:4 358:19 13
criticism [1] 146:1 Danny [1] 8:5 deal [4] 55:22 144:1 196:9 degree [7] 15:6 62:8 64:12
Crosby [6] 4:18 260:17,18,19 dark [5] 43:11,12 81:19 170:3 225:7 122:6,9 250:21 299:8
266:13 298:11 172:20 dealing [3] 302:6 303:8 307: degrees [3] 20:5 105:21 317:
Cross's [1] 257:2 Data [147] 3:12 12:1 13:6,8,14 17 8
cross-sectional [1] 359:13 14:17 15:1,5,7 19:7 20:11 26: dealt [2] 132:21 133:2 delay [6] 22:10 152:12 153:6
crosses [1] 128:7 9 30:8 32:3 33:21 35:20 36: death [46] 18:5,7,9,10,13 50: 283:1 364:4,19
croup [1] 273:17 16 37:2,3,5,9,18 38:1,5 40: 10 75:7 77:15 80:1,4,7 87:11, delayed [3] 22:5 36:13 352:
crucial [2] 116:6 208:3 14 41:5,7 42:9 57:17 63:7 67: 14 90:22 107:2 114:2,2,22 18
crucially [1] 117:16 13 69:5 72:5,8,10,13,20 73:2 123:22 154:9 155:14 156:5, delaying [2] 36:9 364:16
crucified [1] 132:15 91:17 93:6,8,11,13 99:12,15, 10 157:5,8 160:16 167:3 171: delays [1] 195:2
crude [3] 104:11,13 297:17 18 106:6 107:9,9 145:6 151: 9 172:11,16 173:8 174:8 175: delete [1] 277:17
cruel [1] 147:7 12 157:10,19 158:4,4 161:12 15 176:21 177:17,22 180:18 deletion [1] 82:11
cry [1] 143:4 162:8 163:1 166:5 167:18 205:9,11 228:18 269:4,22,22 deliberate [1] 242:19
CSF [1] 350:14 168:2,8 169:11,15 171:2 173: 270:2 273:7 299:1 delineate [2] 341:20 344:6
culprit [3] 89:21 91:5 92:15 19 175:12,13,13 176:17 177: deaths [1] 224:14 delirium [1] 244:21
culture [12] 73:14 153:17 154: 7,16,16 178:8 179:20 193:12 debatable [1] 112:9 deliver [3] 140:3 258:9 307:6
3,5 156:3 158:15,21 160:18 198:7 201:6,7,22 202:21 203: debate [2] 262:1 323:14 delivered [4] 20:22 214:16
204:11 231:17 236:11 263: 15,16 204:11,17 205:4,16 debilitating [1] 196:22 349:19 352:22
12 206:13 214:18 232:7,10 233: debris [1] 82:1 delivery [5] 20:21 21:14 280:
cultured [1] 236:7 16 234:4,6 248:15 261:9 263: decade [1] 235:6 12 353:4 355:5
cultures [3] 155:11 157:7 18 264:17 265:16 267:9 270: decerebrate [1] 252:5 delta [1] 345:1
256:18 13 280:10,14,17 282:7,15 decide [3] 305:3 354:12,13 dementia [2] 237:3 276:18
cumulative [4] 72:2,6 123:1, 288:18 293:17 294:16,17 decided [6] 47:1 88:22 89:5 demographic [1] 32:2
22 298:13 301:3,6,7 306:12,13 119:13 135:13 251:13 demonstrable [1] 227:7
curare [2] 24:3 184:14 308:6 309:20 310:10,17,22 deciding [1] 355:1 demonstrate [3] 24:21 155:
current [7] 10:12 13:12 15:3 312:17,19,22 313:2,5,11,22 decision [1] 355:21 22 287:11
240:6 267:1 319:18 364:8 314:2 315:6 318:3 319:6,11, decision-making [1] 218:9 demonstrated [9] 12:14 26:
15 328:8,10 329:8 331:14,16
demonstrated - doing

18 35:15 149:20 244:2 245:2 8 146:14 200:6 239:12 248: diethylene [1] 28:6 disconnect [1] 227:2
256:16 261:20 264:18 21 257:9 266:2 310:10 325: differ [2] 109:16 112:5 discontinued [1] 171:11
demonstrating [1] 19:7 21 360:1 364:17 differed [1] 122:10 discontinuous [1] 79:5
denominator [1] 38:8 determined [11] 9:13 46:13 difference [17] 123:17 159: discordant [1] 316:14
dense [2] 77:19 81:6 79:22 91:13 105:10 199:17 19 169:3 204:5,13 211:5 258: discover [1] 354:16
density [4] 140:12 257:18 257:17 258:3,5,14 358:17 18 262:4 276:5 286:3 293:13 discriminate [1] 360:13
258:5 321:16 determining [3] 102:17 104: 296:13 305:17 343:14 344:9, discrimination [1] 290:16
dentistry [1] 116:16 7 205:7 9 363:10 discuss [9] 14:22 58:6 84:20,
DEPARTMENT [4] 1:1 6:5 detrimental [3] 12:21 282:4 differences [16] 56:3,13,20 20 85:2 147:2 310:9 312:16
256:13 361:12 317:20 62:5 91:22 92:5 187:13 191: 315:11
dependency [1] 158:13 devastated [1] 124:3 3,6,7 204:7 273:8 323:21 discussed [9] 22:12 288:19
dependent [2] 129:1 236:14 develop [17] 57:3 97:16 99:2 324:3 341:16 359:10 290:3 323:19,20 324:12 329:
dependently [1] 256:17 101:18 136:12 180:11,17,22 different [88] 33:16 42:18 48: 5 330:19 333:8
depending [1] 50:16 222:9 232:5 270:18 285:4 20 49:12 52:2 56:13 58:10, discussing [2] 280:6 312:17
depends [3] 49:13 97:3 259: 289:22 332:2 356:20 359:8 12 62:1,3 70:2,9 76:3,4 78:4, DISCUSSION [22] 4:20 10:4
19 360:15 6 79:13 82:15 84:1 96:4,4,7, 14:14 40:13,13,17 55:16 147:
depressant [1] 197:5 developed [16] 12:3 110:12 7 101:12 102:15,18,20,22 3 182:19 266:19 267:4 276:7
depressed [1] 198:9 112:21 140:5,17 142:2 162: 103:12 106:7,20 107:1 110:4 280:9 282:11 310:8 312:14
deprivation [4] 282:21,22 14 167:6 180:6 185:5 234:11 112:5 119:13 125:20 141:14 313:22 315:18 318:2 322:8
283:5 287:19 275:22 290:18 291:2 321:17 150:7 156:4,7,17 158:1,3 334:10 358:20
derive [1] 232:10 356:18 159:4,13 163:9 164:12 166:1 discussions [4] 45:6,9 46:12
derived [2] 19:2 334:15 developing [33] 11:13 12:20 171:4 175:14 177:19 178:3 358:12
dermatologists [1] 143:22 41:17 42:14 46:3 47:15 50:5 180:3 181:3 190:8 191:9,19, disease [22] 26:14 187:13
describe [4] 48:5,10 51:7 55:12 74:19 77:4 81:17 104: 21 198:1 199:8 204:17 207: 230:12,22 231:16 232:5,6
176:9 19 116:11,12 117:17 118:1 13,20 223:15 232:9 256:17 233:2 234:10,11,14 235:1,3,
described [8] 42:13 48:14 51: 147:14 149:5 165:18 180:5 277:18,18 286:14 295:17 13,17 236:1 245:7,18 263:3
3 75:21 76:1 165:5 205:5 183:13 200:14 234:14 248: 301:4,7 314:22 315:2 319:1 271:13 273:12 332:6
293:9 16 256:19 257:5 265:14 282: 328:21 329:2 336:14,22 343: diseases [1] 223:6
describes [1] 240:7 21,22 285:11 299:11 344:12 1 349:1 352:11,17 353:13,14 dish [1] 119:3
describing [5] 11:6 13:5 52: 361:12 355:15,16 362:21 disorder [2] 106:1 232:6
15 55:21 243:3 development [61] 16:21 18:6 differentiate [2] 111:16 283: disorders [3] 186:17 230:12,
deserved [1] 151:1 43:22 47:19 49:13 51:6 52:3 5 19
deserves [1] 326:4 55:22 56:6 63:8 69:7 77:16 differentiated [2] 75:1 288: disperse [1] 79:1
Desflurane [1] 30:18 81:2 101:12,15 102:2,20 104: 13 disposition [2] 215:4 294:2
Deshpande [13] 2:18 7:5,5 9 106:6 110:14 111:3 112:18 differentiating [1] 282:19 disrupt [1] 241:21
207:22 282:9 307:11 312:6 116:2 118:19 119:5,10,15,19 differentiation [1] 17:21 dissector [1] 138:1
313:18 322:1,15 330:12 333: 134:7 136:8 144:10 145:20 differently [1] 73:15 dissolution [1] 78:17
19 334:7 148:13 160:15 162:22 163:8 differs [2] 18:9 296:3 dissolve [2] 84:8 124:10
design [6] 56:22 126:22 163: 164:7 178:9 179:8 198:18 difficult [16] 38:4 57:13 58:20 dissolved [1] 84:14
19 166:3 202:18 290:6 212:14 234:8 236:1 240:12 101:21 115:12 207:7 210:14 distant [1] 37:13
designate [2] 309:17 311:13 241:2,3,5,8,14,15,21 244:13 212:10 287:5 296:22 298:16 distinct [4] 45:22 51:2 52:1
Designated [1] 6:18 245:22 270:16 272:12 277: 325:3,7 344:14 351:10 358: 233:13
designed [13] 33:15 47:6 59: 19 285:17 305:16 314:14 14 distinguish [1] 91:1
6 118:11 125:6,15 188:4,5 315:7 351:21 diffusion [1] 360:18 Distinguished [2] 219:22
213:9 215:8 222:10 354:22 Developmental [23] 3:15 56: diffusion-tensor [1] 349:3 273:14
359:13 19 74:4,7,21 75:17 101:16,17 Dilantin [1] 281:4 distributed [1] 309:11
designing [3] 153:11 267:21 102:16,20 148:9 173:11 195: dilemma [2] 97:2 104:21 distribution [1] 87:14
364:15 2 199:20 275:14 282:16 283: diligently [1] 326:19 district [1] 31:21
designs [2] 343:3 348:5 1 315:1,4 317:22 336:14 344: dilution [1] 269:18 disturbances [5] 75:9 76:10
desirable [1] 229:16 9 348:7 dimension [1] 82:7 77:7 103:11 106:19
desired [2] 117:22 121:13 developmentally [1] 276:3 dimensions [1] 249:3 divergent [1] 365:3
desires [1] 134:14 deviation [1] 346:8 Dimes [1] 256:11 divide [2] 111:7 191:20
Despite [3] 25:10 26:1,12 devote [1] 182:20 direct [7] 40:21 133:17 136: divided [1] 347:2
destination [2] 111:15 113: dexmetatomidine [2] 320: 10 218:19 243:14 266:21 Division [7] 5:10,20 6:1,4 13:
13 10 335:8 309:21 21 14:15 147:15
detail [5] 36:7 52:15 231:18 di [1] 293:2 direction [2] 164:11 360:18 divisions [1] 45:14
232:9 279:3 diagnosis [2] 347:14 361:22 directions [1] 271:2 DMSO [4] 83:6 124:9,9 284:6
detailed [1] 40:13 diagram [2] 43:4 163:15 Director [6] 5:10,13,15 6:4 DNA [3] 129:11 240:22 241:3
details [4] 221:20 242:21 345: dial [1] 255:22 147:15 249:22 Dobbing [2] 101:21 191:16
4,8 diameter [1] 82:7 dirty [1] 210:2 Doctor [1] 229:6
detect [7] 34:6 36:16 43:11 diazepam [8] 61:13,14,20,22 disabilities [1] 145:9 doctors [1] 223:11
65:3 105:3 175:14 359:9 62:7,13 69:20 347:21 disability [3] 256:21 257:2,7 documented [5] 11:18 222:8
detectable [1] 237:10 die [9] 18:12 113:22 115:17 disaggregates [1] 78:22 223:5,18 234:9
detected [3] 105:5,5,6 139:16,17 140:15 221:17 disagree [3] 309:13 310:4 doing [22] 126:21 147:22 151:
detecting [1] 104:14 361:17,18 311:17 10 152:18 161:16 200:19
determination [1] 38:8 died [4] 220:21 221:4 229:2 discard [1] 314:15 201:2 211:8 231:12 251:7
determine [13] 12:8 30:20 52: 331:1 disclosures [1] 224:20 253:19 267:16,22 271:6 287:
doing - either

12 293:1,16 297:4 304:10 9 141:13 152:1 153:5 158:10 5,5 331:18,21 332:3 333:13 eating [1] 98:17
306:15 338:8 355:11 198:5,9 216:14 263:17 298: 334:16,21 335:4,7,9,14,19,22 Eckenhoff [11] 4:7 142:10
domain [1] 66:15 15 318:13 327:2 336:8 336:3,20 337:13 346:19 229:7,8 234:15 235:20 239:2
domains [1] 328:15 downregulated [1] 314:7 dry [1] 251:2 245:14 246:1 298:8 330:4
dominoes [2] 98:7,15 downregulating [1] 360:10 ductus [3] 185:1 196:16 343: Eckenhoff's [2] 213:15 234:
Don [1] 8:14 downregulation [4] 299:15, 16 21
Donald [1] 2:21 16,21 314:7 due [6] 109:19 110:5 156:1 editor [1] 198:21
done [72] 36:12 68:18 90:18 Downstate [1] 7:10 196:7 220:16 264:20 Editor-in-Chief [2] 6:12 7:3
108:13 109:3 114:18 115:21 dragging [1] 115:17 dumped [1] 325:12 editorial [1] 248:7
117:7,10 118:4 122:19 126: dramatic [13] 37:16 39:15 85: duplicate [2] 46:6 188:6 edits [1] 199:6
20 129:4 133:8 134:1 136:4 6 105:19 113:20 141:16 143: duplicating [1] 188:21 educated [1] 228:20
141:14,17 142:10 143:15,20, 11 158:5 160:10 162:18 173: duplication [1] 46:14 educational [1] 198:20
21 144:7 146:18 166:14,21 15 175:17 324:2 durable [2] 230:5 231:3 EEG [1] 244:18
168:10,16 170:1 178:21 182: dramatically [6] 108:16 122: duration [25] 50:16 61:4 89:1, effect [64] 25:20 58:12 71:7
12 190:19 193:1 195:15 196: 11 159:5 173:13 231:2 236: 6,7 133:18 145:22 164:21 73:16 77:13 87:21 95:13 105:
1 197:10 202:22 209:4,12 10 165:7 176:11 178:16 179:2 3,4 120:2 144:1 149:17 151:
210:17,18 213:15 229:4 255: dramatized [1] 28:8 188:1,18 189:5 191:11 203: 4 152:6,9 153:7 154:22 156:
5 256:3 272:14 281:15 287: draw [2] 93:9 346:11 18 204:18 259:20,20 260:3, 6 157:12,14,17 159:13,15,21
22 291:19 296:5,17 298:1 drawn [1] 319:4 10 271:15 272:9 284:9 160:10,11 161:6 166:21 174:
300:16 301:3 305:15 306:6 dream [1] 254:6 durations [4] 49:12 204:8 18 176:9 179:2 181:6 184:20
307:13,13 310:16 316:8 326: dressing [1] 303:14 333:10 341:8 185:12 191:6 192:13 200:13
3 328:15 348:3 350:13 351: drew [1] 76:12 during [57] 12:10 17:9 18:5 203:16 204:20 206:12 208:
14,21 352:8,10 360:7,8 362:4, drink [1] 226:11 19:15 20:1,3,12 21:14 24:15 22 210:8 221:3 237:18 255:2
22 drop [1] 151:18 25:7,12,15 27:12 28:15 35: 263:1,7 288:14 295:3 296:13
dorsal [1] 278:10 dropout [3] 104:9,18,20 18 43:22 47:19 55:22 77:16 298:2 317:16 323:9 327:16
dosage [1] 70:1 dropouts [1] 103:12 81:2 85:12 93:19 101:1 104: 335:11 337:9,9 338:4 339:5,
dosages [1] 223:15 dropped [2] 216:14 273:1 9 110:18 111:20,21 112:11 5,8 340:17 344:7 351:3
dose [68] 25:5 50:16 53:12,13 drops [1] 151:22 114:5 120:15 121:16 122:3 effective [3] 85:9 210:7 223:
59:14 60:9 61:3 69:19,21 70: drove [1] 297:8 147:3 164:7 184:11,13 186:6, 19
5 86:9,14,16 87:1,5 88:2,6, Drs [8] 11:9 13:9 14:9 42:3 60: 10 190:14,15 193:14,19 196: effectiveness [6] 29:6,19 30:
13 95:4 99:19 136:1 138:14 14 61:6 63:14 202:10 3 201:20 202:6 220:11 241: 11 32:4 223:14 331:20
149:21 150:14,17,19 151:17, DRUG [94] 1:2,3 5:13 9:14 11: 17 270:3 272:11 276:21 277: effects [87] 12:18,21 16:20
18,20 153:2 155:10 158:13 16 12:1 13:17,18 20:16 24: 19 279:8 305:10 316:9 317: 19:5,12 20:2 21:2 30:7 41:16
164:20 165:2,7 166:17 171: 14 25:12,15,22 26:11 27:1,16 21 332:12 340:5 47:14 48:11 50:4,21 58:5,9
11 185:3 188:9,9,15,21 190: 28:3,8,10,11,22 29:2,2,4,4,5, dust [1] 83:14 65:6 70:18 78:14 114:19 140:
20 191:11 203:19,22 206:1,2 13,22 30:11,20 31:9,12,19 32: dwindle [1] 23:15 22 141:2 145:5,7 146:12 147:
214:15 215:13 225:19 236: 10,21 33:3,12,19 34:11 37:12 dying [6] 123:21 124:4 150:9 13 150:21 151:15 152:14
14 244:19 249:11 256:1,17 39:6,10 42:10,11 44:21 50: 155:22 156:1 172:20 157:21 160:2,21 166:2 168:
257:9 259:19,21 260:2,9 278: 17 56:6 62:8 64:13 67:17 70: dynamic [2] 184:9 186:9 13 173:4,22 175:6 176:13
19 335:21,21 336:7 342:12, 5 84:13 85:12,14,15 89:22 dysfunction [4] 237:1,3 267: 177:4 178:11,18 179:19,21
13,19 188:22 191:7,8,9,11 192:13 7 330:5 181:1,8 185:13 194:2 202:3
dose-dependent [1] 64:10 198:17 210:11 218:7 220:3, 203:17 209:6,9 210:12,13,13,
dose-related [1] 177:15 21 221:5,9,12 222:18 223:12,
E 22 214:2 229:16,18,19 230:5
dose-relatedness [1] 150: 19 227:18 228:21 231:4,8 E-VAD [1] 237:16 240:19 241:21 242:5,8 244:
22 240:19 251:1 255:14 262:7 each [32] 13:10 70:5,8 78:4 15 246:22 248:12 260:22
dose-response [13] 88:6 280:4 294:1,2,15 320:22 322: 80:15 85:14 100:22 102:18, 261:10,16,18 265:16 267:11
118:13 149:15 164:18,19 5 329:18 332:11 334:11 336: 19,21 103:9 106:22 116:7 275:11,19 282:4 283:2 288:
191:3 246:6 328:17 338:17 2,11 337:3 340:17 148:17 166:15 177:7 200:17 13 295:3,11 297:5 299:10
342:6,10,17 353:11 drug-induced [2] 75:16 242: 209:17,20 219:17 221:19 301:4 317:20 319:8 324:19
dosed [2] 151:14 228:9 9 232:12 235:19 240:14 297: 327:14 359:7
doses [35] 25:4 53:17,20 57: drug-review [1] 45:14 18 300:19 301:7 303:16 336: efficacious [2] 24:11 33:17
14 59:12 64:4,17 70:7 85:4 drug-safety [1] 221:14 2,19 339:8 355:12 efficacy [11] 23:21 29:4,22 31:
86:8,22 88:4 125:12 150:13 DRUGS [98] 1:4 2:4,12 5:5 9: earlier [18] 39:4 87:3 101:17 9,21 32:6 227:8,11,15 228:1,
153:2 156:3 188:19 190:15, 9 12:19 22:9,16,21 23:8,11 113:17 135:1 175:4 178:9 2
15,17,18 203:17 206:5 207:3 24:9 26:15 27:2,4,10,14 28: 179:12 208:15 262:17 263: effort [1] 12:4
273:19 321:4 332:2 333:10 12 29:15,19 32:9,16 35:1 40: 21 266:3 329:5 330:14 331:1 efforts [5] 32:19 33:21 45:21
335:16,16 336:4,5 341:9,10 2 41:17 44:10 55:21 66:19, 333:20 362:9 363:13 57:12 325:20
353:20 21 67:14 69:21 70:1,2,8 75: early [15] 10:20 12:13 21:1 78: eighteen [1] 220:13
dosing [5] 23:13 33:15,17 18 76:17 82:19 83:4,12,18 10 84:4 103:3 110:18 115:6 eighth [1] 355:5
206:4 227:20 97:18 99:3 110:4 186:10,18 184:1 212:14 240:3 316:7,19 Eisenach [24] 2:7 6:10,10
dotted [1] 136:17 187:4 188:1 190:17 194:3,21 331:15 332:4 103:13,14 195:3 279:15 280:
double [1] 204:3 195:8 197:5,6 210:2 226:19 earmark [2] 325:19,20 14,22 281:5,16 312:10 315:
double-blind [1] 347:1 227:3 229:11,16 230:17 231: ears [1] 142:19 19 324:21,22 326:15 330:2
Doubletree/Hilton [1] 1:8 9 233:11 242:8 249:5 250:16, ease [1] 255:17 335:2 337:3,6 349:16 350:2
doubt [4] 124:20 148:8 287: 17 251:7 254:1 275:10 279: easier [2] 255:7,10 352:14 353:12
10 346:9 11 281:2,6 319:16,17,21 320: easily [1] 168:12 Eisenach's [2] 199:6 281:19
down [16] 24:7 39:1 89:1 129: 14,19 325:4,13 327:21 328:4, easy [3] 121:9 162:13 253:10 either [29] 36:11 62:8 64:13
eat [3] 98:22 99:4 107:5
either - experimentals

84:2 97:6 116:17,20 118:12, end-tidal [4] 137:10,10 252: 20 137:12 139:22 250:16 269:
14 124:4 156:2 162:8 166:14 22 253:12 estimate [2] 69:8,9 21 272:19 285:20 296:4,22
178:10 183:18 185:2 188:9 ended [1] 22:11 estimated [1] 235:8 297:1,19
200:22 201:14 228:7 233:1 endorsed [1] 30:11 et [19] 19:1 42:3 46:4,10 53:4 examination [1] 329:4
237:2 257:22 258:16 263:5 endpoint [4] 68:3 117:21 141: 59:6,8 60:15 61:6 62:15 64: examine [3] 30:6 38:13 187:
301:16 337:22 347:20 351:6 12 345:16 15 65:16 72:21 88:14 90:10 10
elderly [4] 248:17 264:11 289: endpoints [7] 54:15 163:9 91:5 205:2,2 215:5 examined [5] 62:17 70:17
10 330:5 165:13 199:21 207:18 290:9 ethanol [22] 71:8 76:19 77:2, 154:21 167:1 334:16
elders [2] 264:16 265:5 318:8 11,18 80:11,21 81:4,18,21 82: example [24] 26:13 27:2 51:
elective [4] 305:7,9 307:15 ends [1] 337:19 12,18 83:18 84:12 85:19 93: 16 56:12 78:15 84:9 104:14
364:22 energize [1] 240:15 7,18 94:4 194:17 231:12 279: 114:22 132:21 137:19 148:
electroencephalographic engage [1] 249:7 6,6 21 210:4 218:20 270:19 285:
[3] 328:14,16,18 engender [1] 15:11 ether [3] 141:11 143:7 251:4 17 295:15 300:21 303:7 318:
electron [4] 78:8 81:13 90:21 England [2] 185:17 316:11 ethically [1] 325:2 11 338:14 339:9 350:16 351:
300:14 enhance [1] 237:20 Etomadate [2] 323:12 328: 17 354:16
electron-microscopic [1] enhanced [7] 221:2 231:22, 22 exceeded [1] 85:16
81:11 22 233:19,20,22 234:2 Europe [3] 28:18,20 117:12 excellent [4] 126:7 267:15
electrophysiological [1] 54: enjoys [1] 110:17 euthanize [1] 94:7 284:16 365:14
17 enormous [3] 110:18 111:8 Evaluate [10] 3:21 29:19 47:7 except [7] 92:7 122:2 125:21
element [4] 115:13 211:9 283: 363:8 56:9,18 97:11 147:18 156:8, 130:11 131:1 231:18,19
15 305:2 enough [10] 61:22 69:16 93:9 14 240:2 exception [1] 262:21
elements [3] 114:14 116:2 138:8 195:5 298:17 301:19 evaluated [6] 31:10 65:8,22 excess [1] 240:22
221:11 310:17 345:7 346:16 67:2,3 171:13 excessive [1] 18:18
elevated [3] 85:21 86:2 105: ensure [2] 29:3 218:10 evaluating [2] 106:16 257:18 exchange [2] 32:11 302:2
17 ENT [1] 347:14 EVALUATION [9] 1:3 5:13 9: excitation [1] 116:22
elevations [1] 242:4 entail [1] 90:20 15 12:2 33:11 44:21 54:17 excited [2] 100:21 224:4
eliminate [3] 253:7 286:1 enter [1] 188:11 289:17 328:9 excitory [1] 193:20
308:22 enterocolitis [1] 344:13 evaluations [2] 70:14 277:8 excitotoxic [4] 49:16 50:13
eliminating [1] 18:17 entire [3] 30:12 74:16 79:6 even [45] 9:6 20:4,8 31:8 57:5 51:14 90:22
ELISA [2] 154:4 161:1 entirely [1] 58:14 73:14 102:4 104:11 124:18 excitotoxicity [4] 49:22 50:5,
elixir [1] 28:5 entrance [1] 353:7 132:22 133:9 135:12 138:12 22 51:21
Ellen [2] 200:15 228:16 entry [1] 360:12 146:4 162:2 179:12 180:14 exclude [2] 10:8 297:5
eloquently [1] 249:2 environment [4] 30:7 76:22 185:18 190:12 202:2 207:1 excluded [1] 31:4
elucidated [2] 35:1,9 83:11 211:16 211:22 212:20 216:14 222: exclusion [1] 10:9
EM [4] 173:20,22,22 174:2 environmental [5] 17:10 47: 21 250:13,21 255:8 263:14 exclusively [1] 141:15
embryological [5] 241:1,2,5, 8 51:7 106:20 220:7 268:4 277:10 293:10 298:8 exclusivity [3] 31:15 32:8,10
7,10 enzymatic [1] 240:16 307:14 308:2 323:13 324:3, executioner [1] 79:21
embryonic [3] 62:15,21 63:3 enzymes [3] 237:21,22 238: 20 332:12 337:12 339:2 340: Executive [4] 1:9 2:3 8:18
emerge [1] 276:4 15 10 346:21 355:11 360:18 349:11
emergence [1] 244:21 Epidemiology [1] 38:13 event [5] 10:4 36:21 37:10 exhaustive [1] 109:14
emergency [1] 192:16 epileptiform [1] 244:18 274:18 275:20 exist [3] 15:6 103:17 355:17
emergency-room [3] 188:12 equal [3] 38:17 364:18,20 events [16] 33:22 34:7,8 36: existing [3] 15:18 69:10 364:
322:16 323:13 equally [1] 233:12 19 37:15 38:4,14,20 39:4,13, 13
emergent [3] 195:15 307:18 equate [1] 189:9 14 101:15,16 245:1 247:14 Exogenous [1] 18:1
349:22 equation [1] 315:3 315:1 exogenously [1] 231:22
emerging [2] 240:1 317:1 equipment [1] 167:16 eventual [1] 50:15 expand [1] 103:20
Emily [8] 220:12,17,21 221:4, equipotent [1] 118:13 eventually [6] 111:18 163:17 expansions [1] 278:9
5 223:22 224:10 228:17 Equity [1] 32:14 165:21 211:12,20 212:1 expect [10] 15:8 129:13 136:
Emily's [1] 221:8 equivalence [2] 344:18,22 every-day [1] 286:5 10 173:9 198:8 201:5 294:5,
emotional [1] 275:9 equivalent [3] 60:8 103:21 everybody [3] 233:15 260:18 7 346:10 358:15
emphasize [7] 93:12 239:10 314:16 311:6 expectancy [1] 48:21
264:1 265:12 266:2 270:21 era [1] 292:21 everything [8] 37:20 118:6 expectation [1] 129:14
300:18 ergic [1] 229:12 134:18 136:4 139:4 298:15 expectations [1] 131:17
empiric [1] 336:19 error [3] 170:8 215:20 324:11 303:18 359:6 expected [2] 48:21 114:5
empirical [1] 243:8 esophageal [1] 196:15 everywhere [1] 139:6 expedition [1] 347:9
employ [1] 97:13 especially [10] 27:13 34:10 evidence [40] 11:12 12:20 17: expenses [1] 218:22
employed [2] 10:2 11:16 35:14 145:18 149:2 178:1 15 21:4,13 25:1 26:8,20 29:8 experience [6] 26:10,22 152:
employee [1] 243:21 212:14 233:10 252:8 327:10 36:5 53:18,20 60:1,10,16 65: 10 226:6,7 227:5
enact [1] 28:9 essential [3] 15:14 154:16 3 67:5 86:19 106:15 179:18 experiment [6] 93:17 118:12,
enantomers [1] 288:14 231:6 205:3 235:14 242:6 244:9 13 285:3 292:4 353:11
encompassing [1] 342:19 essentially [4] 153:5 251:14 245:4,16 246:11 248:12 259: experimental [18] 30:8 102:8
encourage [1] 57:2 255:13 347:8 17 261:16 262:9 263:6,11,13, 121:11 122:17,20 125:20
encourages [2] 218:14 219: establish [5] 28:8 29:14 209: 14,21 265:1,14,21 335:15 127:8,15,21 135:21 137:16
2 14 344:21 345:1 evolution [1] 27:17 139:21 163:19 187:21 189:8
end [6] 38:15 119:18 179:10 established [4] 30:6 45:3 66: evolving [2] 11:22 13:11 284:7,18 285:21
216:12 305:16 332:2 1 86:18 exactly [19] 53:7 58:1,14 68:7 experimentals [2] 139:22
end-organ [1] 190:6 establishment [2] 44:18 57: 71:10,11 78:1 83:3 116:10 286:4
experiments - Fluoro-Jade

experiments [5] 95:1 122:19 57:14 310:22 313:8 314:14 fatal [2] 222:22 252:12 figure [4] 42:22 43:1 127:10
163:21 164:3 268:9 extrapolated [2] 15:7 313:4 fatalities [1] 39:9 337:20
Expert [3] 44:19 109:12 302: extrapolates [1] 189:6 fate [1] 139:14 figured [1] 161:3
6 extrapolating [1] 293:12 father [1] 220:16 figuring [1] 125:8
explain [3] 258:11 306:5,10 extrapolation [3] 69:6 102: FDA [49] 2:28 3:20 10:6 15:14 fill [1] 179:6
explained [2] 233:22 258:13 13 104:22 19:2 23:3,17 27:16 28:21 29: filling [1] 52:17
explains [3] 240:4,17 242:11 extrapolations [1] 310:18 6,11,17,22 30:11,19 31:1,17 final [4] 106:18 111:15 113:13
explanation [2] 77:5 91:15 extreme [1] 330:14 32:1,13 44:7,19 45:19 147: 333:5
explicitly [1] 222:6 extremely [3] 321:5 325:9 15,17 149:14 182:8 183:7 finally [11] 83:18 90:15 96:15
exploration [1] 289:2 336:18 202:11 218:11,14 219:2 221: 98:10 133:21 191:13 224:9
explore [4] 248:9 249:9 319: extremes [1] 324:8 21 222:3,5 223:2 225:3 226: 238:2 244:10 247:3 261:11
17 342:7 extremis [2] 184:7 197:2 21 227:3,17 229:4 243:10,19 financial [12] 9:12 10:6,12
explored [2] 270:12 294:3 extrinsic [4] 129:1 131:12 248:5,14 318:2 319:6 325:19 218:17,20 219:4,7 220:4 224:
expose [7] 93:19 116:11 153: 299:3 300:8 326:8 334:18 20 234:19 250:5 256:10
21 159:5,12 160:3 232:21 eye-opening [1] 163:9 FDA's [5] 12:1,11 27:21 222: find [18] 78:13 88:1,5 95:22
exposed [33] 11:7,21 12:22 eyes [1] 152:15 14,16 125:19 126:13,17 138:5 181:
20:5 47:18 55:10 88:21 105: FDA-approved [1] 23:12 5 209:9 258:17 262:3 270:22
16 118:18 139:3 144:13 145:
F FDA-related [1] 16:16 289:4,17 338:22 343:6 359:
19 154:19 165:14 176:6 226: FAB [1] 299:6 FDA-wide [1] 44:19 21
13 268:9 279:7,10,22 280:3 face [7] 55:17 58:19 68:1 143: FDAMA [2] 31:13 32:9 finding [8] 36:19 73:16 130:
285:8 298:14 346:19 352:21, 4 187:14 208:6,9 feasible [1] 343:2 22 138:18 210:5 249:10 314:
22 353:13 354:2 355:3,14 faced [1] 196:4 feature [4] 149:3 154:11 169: 9 327:21
359:15 360:1 361:19 facets [1] 13:10 21 360:6 Findings [44] 3:25 11:11 12:
exposing [4] 123:14 125:17 facilitate [6] 235:22 238:15, features [1] 79:8 17 14:2,19,21 15:11 24:18
139:21 343:4 17 239:8 243:7 251:12 February [1] 33:10 25:4,10 40:5 41:21 46:7,9,10,
exposure [80] 12:18 13:3 20: facilities [1] 167:15 Federal [5] 6:18 24:15 28:10 14 47:18 52:15 55:9 56:19
12,14,19 34:10 38:9 54:1 60: facility [1] 167:14 31:21 325:10 57:21 59:4,7,21 60:17 61:16
12 61:1,2 63:4 71:22 72:2,7, fact [25] 48:15 115:15 125:9 feed [2] 135:8 284:2 62:20 63:10,22 64:3,16 65:
22 73:9 85:4,11 86:11 100:3, 176:5 185:18 186:8 212:11 feel [13] 156:7 174:18 176:16 10 66:10 96:22 183:2,4 186:
6,9 103:16 105:3 136:7 139: 229:22 231:13 250:9 262:3, 177:13 185:20 215:22 221: 16 268:18 297:13 301:10
20 146:19 159:14 160:9,17 10,20 263:1 264:10 294:19 21 270:22 290:9,20 325:8 310:11,22 312:20 343:9
171:12 172:17 173:1,2,3 175: 302:1 329:18 335:18,20 338: 326:11 357:2 finds [1] 332:22
18 176:3,4,12 178:17,19 186: 6 340:1 346:20 349:20,21 feels [1] 326:14 fine [4] 117:15 211:8 333:16
18 188:1 189:9 195:7 204:8, factor [5] 89:10 248:1 302:18 fellow [3] 117:8 184:19 267: 352:12
18,22 205:2 231:4 242:18 316:14 360:12 16 finesse [1] 349:13
244:2,6,12,15 245:5,11,22 factors [9] 235:21 296:12 felt [1] 158:15 finish [2] 174:15 181:12
247:3,19 248:2,13,21 276:11 299:10 346:22 347:2 350:1 female [2] 73:15 168:14 firm [1] 10:13
279:13 286:17 296:16,20 357:17,21 358:6 females [1] 169:4 firms [2] 9:14 10:5
301:1 305:2 313:3 319:9 331: fade [1] 23:14 fentanyl [18] 30:3 135:13,14, first [58] 5:5 10:15 22:16 24:
16 332:4,13 333:11 341:8 fail [2] 253:2,3 19 138:8,14 182:1 185:3 197: 22 25:8,18 29:5 33:2 42:1 44:
346:21 350:18 failed [2] 24:21 350:15 16 321:7,11,18,19 323:1,3,6, 6 48:18 53:3 54:20 55:4 59:5
exposure-response [2] 278: failure [2] 75:6 247:15 8 347:22 72:18 76:5,9 78:18 83:5 98:8
21 342:16 faint [1] 96:13 fentanyl-based [1] 197:15 99:8 100:1 110:18 111:21
exposures [13] 59:19 60:7 Fair [6] 69:16 106:5 289:7 ferret [1] 338:16 112:12 142:11 144:7 157:4
72:7 104:3 157:20 159:2 192: 297:14 363:22 365:1 fetal [25] 19:20 25:11 26:8,19, 176:9,11 178:13 187:21 208:
14 203:15 204:19 246:4 329: fairly [19] 109:11 118:5 134: 20 71:2,13 76:21 77:7 93:17 1 219:18 220:14 229:8 230:
2,3 363:9 10 138:14 151:21 170:8 185: 99:9 103:19 104:4 105:1,20 15 237:7,7,14,15 238:13 256:
expound [1] 333:16 3 219:15 252:10 272:17 278: 192:15 194:19 195:1 196:1,6 9 257:8 261:14 270:8 283:15
express [2] 34:9 326:12 13 288:4 297:17 304:2 305: 208:20 259:6 269:14 279:9 309:9 310:9 311:10 316:15
expressing [1] 330:1 21 321:19 333:4 338:2,2 350:10 325:1 328:4 342:5 343:22
expression [6] 107:7 241:3 fairness [1] 10:11 fetus [18] 21:5,15 24:22 25:20 347:8,11
299:2 318:6 328:10 338:3 fall [2] 27:5 281:20 35:15 63:4 94:7,7 95:7 105:4, fishing [1] 347:8
extant [1] 31:19 familiar [2] 144:15 149:7 16 185:13 192:15 257:5,17 fits [2] 234:1 326:17
extend [3] 16:10 46:7 59:7 families [1] 224:6 279:6 351:2,20 fitting [1] 155:5
extended [2] 32:10 127:19 family [2] 37:4 220:15 fetuses [8] 62:16,21 108:18 five [5] 10:19 24:16 162:14
extending [1] 55:1 far [23] 41:15 67:13 94:16 99: 113:1 171:10 185:14 186:10 273:19 365:6
extends [2] 49:9 69:3 19 112:5 120:16 125:12 131: 352:7 fixed [2] 337:8,9
extensive [5] 125:2 137:16 12 132:17 152:22 173:10 few [16] 82:1 95:15,16 99:7 flashing [1] 84:18
197:17 268:6 319:4 193:9 195:3 198:3 216:13 109:10 128:19 173:11 206:4 flip [1] 316:2
extensively [1] 295:16 263:20 270:1 281:14 282:4 268:20 275:21 316:20 323:5 floor [1] 233:2
extent [6] 18:17 216:17 253: 288:15 318:5 324:19 364:7 347:17 351:16 355:10 358: Florida [1] 247:18
14 294:22 321:2 333:10 Fas [2] 131:18 132:2 15 flow [6] 121:8,13,16 122:1
external [2] 78:17 299:8 fascicularis [2] 94:1 95:2 fibrosis [1] 82:2 166:21 216:17
extra [3] 10:19 31:14 253:20 fascinating [3] 68:5 255:1 field [3] 94:12 116:12 146:6 flows [1] 121:20
extracted [1] 94:13 332:15 fields [1] 225:14 fluid [1] 251:2
extraordinary [1] 280:3 fashion [10] 24:5 34:21 146: fifth [1] 295:4 Fluoro-Jade [4] 167:6 173:6
extrapolate [6] 30:8 55:19 18 158:2 168:16 190:20 197: fifties [1] 184:2 175:13,21
15 231:3 299:14 359:9
focus - greatest

focus [18] 13:5 16:16 46:20 fragmentation [1] 129:11 11,21 233:11,12 295:2 getting [13] 155:13 162:11
49:18 50:4 52:5 53:3 110:8 fragmented [1] 79:4 GABA-ergic-agonist [1] 172:3 174:12 192:20 204:1
229:9 230:4,6,7 242:9 260:9 frame [7] 17:6 49:4,13 92:19, 296:10 207:18 221:6 253:21 286:4
261:7 289:15 319:20 320:15 19 93:2,15 GABA-mimetic [4] 19:4 76: 320:11 350:15 361:14
focused [2] 51:15 283:3 Framingham [1] 282:14 20 82:20 84:3 GI [1] 72:4
focusing [12] 41:14 48:12 50: Frances [1] 28:21 GABA-mimetics [1] 83:21 girl [1] 220:10
4,8,19 51:2 52:10,16 85:7 Francisco [1] 248:8 GABAA [1] 82:17 give [21] 54:8 68:12 74:18 89:
110:9 111:4 146:19 frank [3] 105:12,14 306:1 gaining [1] 248:3 18 109:16 112:4 123:10 133:
fold [6] 122:13,21 131:2 138:6 Franks [2] 117:10 294:18 Galveston [1] 8:13 12 138:9 160:4,14 176:4 178:
264:8 268:20 Fredriksson [2] 61:6 69:18 games [1] 291:7 14 183:13 202:10 206:11
folks [1] 264:11 free [1] 253:11 gamma [1] 238:16 211:20 307:9,9 342:13 353:
follow [13] 10:18 17:16 30:1 frequently [8] 39:5 144:13 gamma-aminobutyric [1] 18
120:7 165:14 205:20 212:7 184:8 188:11 195:17 197:2 17:18 given [15] 32:13 88:3 149:22
234:21 275:12 285:5 316:8 323:12 334:12 gamma-secretase [1] 237: 153:3 166:17 171:15 188:8,
353:16 355:6 friendly [1] 224:1 22 15 317:17 340:5 341:15 349:
follow-up [3] 317:12 348:2,8 friends [2] 37:4 182:8 gas [12] 83:15 90:4 117:9 120: 20 353:19 356:4 364:3
followed [7] 91:11 99:19 119: front [2] 70:19 179:10 5 137:8 257:11 284:20 287:1 gives [6] 107:14 123:21 159:8
3 125:16 132:8 166:15 285:7 frontal [7] 95:9 153:18 156: 320:17 343:22 344:17 362: 160:1 175:10 234:7
following [16] 9:4 14:9 23:9 14,22 171:22 276:8 278:7 18 giving [9] 10:19 99:18 151:15
34:10 39:5 77:11 80:10,20 frontotemporal [1] 349:2 gases [1] 57:9 158:16 189:8 190:17 325:4,4
81:4,21 87:15 90:6 218:5 full [4] 99:18 221:19 224:8 Gate [2] 240:5 249:19 342:12
222:13 247:2 280:19 335:19 gathering [1] 218:9 Glasgow [1] 200:17
Fontan [1] 332:10 full-term [1] 275:5 gauge [1] 331:3 glass [1] 103:21
FOOD [5] 1:2 28:9,11 31:12 fully [16] 35:1,9 37:7 73:21 86: gave [11] 29:1 31:14 73:1 150: glial [3] 82:3 111:5,10
218:7 16 88:2 110:12 112:21 140:5, 13,14,17,21 171:11,12 188: glucose [7] 91:20 92:6,9 137:
forces [1] 240:19 17 202:19 206:17 214:18 21 190:2 8 168:3,5 257:11
forefront [2] 331:2,6 288:16 289:22 321:17 gazillion [1] 336:22 glutamate [8] 17:18 75:18 82:
Forest [1] 6:11 function [16] 17:13 55:13 gender [8] 31:1 32:4 37:20 17 115:22 116:6,19,21 117:
forgive [1] 42:4 154:16 157:16 158:11,22 73:13,16 323:18,21 329:4 16
form [8] 111:16 113:14 116:8 159:5 165:12 177:5 180:6 genders [1] 31:3 glutamatergic [2] 229:11,21
169:16 223:21 238:10,20 240:9,21 276:13 290:14 291: gene [4] 107:12,12 318:6 328: glutaminergic [1] 18:2
243:1 8 349:11 10 glycol [4] 28:6 83:8 84:7,11
formal [3] 310:19,20 332:17 functional [10] 62:9 125:4 General [37] 4:9 9:22 11:15 goal [2] 216:15 222:8
formation [6] 111:4,10 112: 148:12,18 180:4 186:22 187: 12:19 21:18 22:6 83:22 108: gold [1] 78:9
14 115:4,10 234:1 6 198:7 268:3,6 6 110:1 116:14,15 145:9,18 Golden [1] 249:19
formed [2] 111:18 200:11 functioning [1] 161:13 163:8 201:1 225:8,10 230:18 Goldilocks [1] 249:4
forms [2] 27:3 245:8 functions [3] 110:6 149:4 245:15 246:4,22 247:7,12 gosh [2] 250:7 251:22
formula [1] 250:22 241:1 260:22 261:16 262:3 263:15 got [14] 135:6 137:15 150:15
formulated [1] 240:6 Fund [1] 256:14 266:19 288:8 295:2 309:8 152:8 155:11 206:10 211:22
fortunate [5] 13:7 42:6 52:13 fundamental [1] 271:5 325:8 327:11 336:18 349:19 212:18 253:16 266:1 302:20
185:10 290:22 funded [3] 47:21 201:9 325: 350:17 356:1 304:18 325:12 356:22
forum [1] 219:9 16 generally [10] 20:18,19 21:16 gotten [1] 365:9
forward [5] 14:16 100:6 308: funding [3] 199:7 202:17 329: 24:17 32:22 33:14 35:2,10 govern [2] 240:10 241:10
21 312:19 325:7 20 241:22 270:22 government [2] 12:7 325:10
found [57] 28:18 35:17 75:22 funds [1] 47:3 generate [1] 162:8 governs [1] 241:3
76:15 77:2 82:16,21 83:2 86: further [30] 11:12 12:4 14:17 generated [1] 241:13 gradients [1] 106:1
7 87:19 89:8,13 107:13 118: 22:5 36:1,4 40:13 41:20 45:4 generation [13] 226:11 233: graft [1] 247:14
18,20 119:1,5 121:22 122:8 46:18 47:7 51:4 59:2 70:14 19 237:11,14,19 238:1,11,18, Grail [1] 298:7
127:2 128:8 130:17,22 138: 89:6,11 106:10 107:8 151:1 19,21 239:8,9 241:8 grams [4] 110:17 120:22 133:
17 140:7,10 141:18,21 144: 153:14 163:15 185:22 202:4 generic [1] 24:5 1,4
16 164:2 185:4,13 188:16 206:22 232:22 236:12,17 generous [1] 114:8 grandson [1] 228:21
189:1 235:10 236:5,12,17 267:22 333:16 334:9 genes [4] 107:7 260:7 314:6 grant [2] 95:1 256:12
237:7,16,20 238:2,8,12,22 Furthermore [4] 184:6 189:4 360:9 granted [3] 26:2,6 33:17
247:6,19 267:17,18 268:15 193:16 194:20 genetic [3] 195:19 197:1 293: grants [1] 201:10
272:17 273:7 275:6 282:3 future [13] 180:13 228:21 260: 22 graph [1] 340:10
299:11,19 316:18 9 266:2 270:10 292:21 293:4 genetics [1] 294:1 graphs [1] 340:2
Foundation [1] 256:12 319:22 320:9,13 337:16 352: genome [2] 240:20 293:10 grapple [1] 207:8
founder [1] 228:22 9 356:19 genomic [4] 166:2 293:1 301: grasp [1] 211:17
four [8] 20:18 22:6 148:16 futuristic [1] 74:14 7 328:9 grateful [1] 15:21
162:14 225:22 295:17 338: gestation [9] 17:4 49:9 93:20, gratitude [1] 202:10
22 339:6
G 21,22 164:14 215:11 269:8 gray [2] 274:17 275:7
four-fold [1] 332:11 GABA [15] 17:19 19:12 39:10 353:14 great [6] 126:9 137:1 167:9
fourth [1] 124:13 71:10 76:13 116:1,5,17,21 gestational [7] 63:8 66:2 166: 197:13 256:4 357:6
fraction [1] 191:9 117:4,16 181:21 210:8 297: 9 170:4 175:17 178:10 352: greater [11] 25:5 29:4 53:2
fractures [2] 188:13 322:18 16 321:12 18 62:7 64:12 162:5 176:7 234:
fragment [1] 18:12 GABA-A [3] 76:13,14,18 gets [6] 87:5 253:15 297:6 14 242:18 316:19 317:7
fragmentated [1] 174:7 GABA-ergic [11] 18:1,18 66: 322:22 339:3 351:14 greatest [3] 164:7 235:3 349:
21 106:8 209:19 210:12 229:
greatest - HUMAN

5 21 142:4 155:22 163:15 180:12 322:6
green [2] 219:11 316:10 handouts [1] 6:22 200:6 204:6 243:7 268:7 277: hit [3] 165:3,5 278:20
Greg [1] 260:19 hands [6] 202:2 210:9 309:13 8 289:21 315:3 318:4 319:6 hit-and-miss [1] 37:9
Gregory [1] 4:18 310:1,3 338:22 328:9,14 349:8 354:12 361:2 hitting [1] 352:3
gross [1] 65:6 hanging [1] 338:8 362:4 HIV [1] 276:18
ground [1] 148:3 haphazard [1] 351:8 helped [2] 28:9 58:4 hockey [1] 278:20
groundbreaking [1] 149:8 haplotypes [1] 293:3 helpful [7] 39:20 289:18 290: hold [2] 182:18 205:6
group [59] 23:22 44:19 46:8 happen [7] 98:13 111:20 112: 4 293:4,18 310:7 321:5 holding [1] 74:15
49:3 59:4 63:11 143:22 147: 15 114:17 115:2 135:9 286: helping [2] 161:14 199:17 Holtz [1] 8:8
7 183:7 184:21 185:4,11,22 21 hemodynamic [2] 57:10 307: Holy [1] 298:7
186:14 187:2,19 188:5 191: happened [5] 130:14 133:8 22 home [2] 142:22 297:8
22,22 192:2 193:1,13 194:18, 150:7 179:15 274:6 hemoglobin [2] 100:11 168: homeostasis [1] 146:5
20 196:1 198:19 199:15 200: happening [6] 104:21 108:9 9 Honorable [1] 219:19
12 202:11 207:1 230:8 231:6 111:20 250:16 266:10 285: hemorrhage [1] 273:6 hope [3] 146:13 261:9 356:19
233:10 234:9 246:2 247:6,17 12 hemorrhages [1] 185:8 hopefully [2] 200:5 254:15
253:8 254:5 257:2 261:19 happens [18] 36:18 37:13 92: hemostasis [1] 133:11 Hopkins [1] 6:5
262:14 264:5,16 271:21 274: 18 93:1 110:21 112:11 113: Henthorn [10] 2:8 6:7,7 70: hormones [1] 186:6
2 294:18 314:20 320:9 326: 11 116:3,8 118:21 123:20 21,22 288:20 312:11 315:20 horrendous [1] 358:1
11 343:17 344:2,2,14 346:1 139:7 140:5 207:19 236:21 329:11 336:17 horribly [1] 326:21
350:5 359:15 363:11 364:12 314:8 356:8 358:3 Henthorn's [1] 287:22 Hospital [9] 4:9,19 7:15,20 8:
Groupe [5] 2:3 3:5 6:17,17 9: happily [1] 211:22 hepatic [1] 110:5 8 185:11 197:12 306:2 348:7
4 happy [7] 127:15,17 135:3 hernia [3] 286:12 344:5 362: hospitals [1] 200:18
groups [11] 78:6 80:16 81:6 224:8 243:9 275:2 341:22 20 Hotel [1] 1:8
103:2,4 191:21 199:7 258:8 harbinger [1] 230:22 hernias [1] 200:20 hour [13] 78:20 89:11 91:11,
264:10 299:2 347:2 hard [4] 120:7 141:4 182:7 herniorrhaphies [1] 287:3 21,21 92:3 126:1 144:12 151:
grow [2] 153:21 277:19 225:14 herself [1] 224:2 22 153:4 166:20 203:17 340:
growing [10] 17:15 27:15 40: harder [2] 215:15 253:20 hesitate [1] 229:18 8
4 66:14 67:20 221:11 225:1 hardly [1] 234:7 Hickey [1] 185:12 hours [119] 53:9 55:10 59:12
245:3 277:20 285:11 harm [5] 25:11,14 245:4 302: hidden [1] 245:4 65:1,2 66:5 80:10 81:18 88:
grown [1] 34:5 9 306:16 high [32] 85:4,20 86:2 109:20 22 89:2,7 91:19,21,22 92:4,5,
growth [8] 17:3 76:1 110:15, harmful [3] 194:15 244:15 185:3 190:17 206:2 221:22 17 94:5,6 95:3,6,6 105:18
18,20 111:1,2,8 317:16 222:8 226:4 227:6 244:17 120:5,6 121:19 122:8 125:18
Grunau [1] 317:2 harming [1] 202:19 260:2 272:17,19 273:19 295: 129:21,22 130:12,18 131:1,8,
guess [6] 270:9,10 280:8 307: Hartman [1] 125:15 19 318:12 326:7 329:21 330: 8,9 132:2,3,9,11,11 133:7
7 308:12 326:9 Harvard [4] 4:9,18 7:15 257:3 11 332:2 335:16 336:5 352:3 135:20 136:12 138:15 139:4
GUEST [1] 2:26 hate [1] 126:8 353:20 354:2 355:4,19 360: 152:1,5,5,8,11 153:4,4,5,7
guests [1] 11:3 Hayashi [3] 53:4 60:15 188:5 13,14 364:19 154:20,21,22 159:6,12,14,19,
Guidance [4] 33:10 310:7 HBA [1] 317:9 higher [20] 60:20 61:2 64:2 21 160:17,20 165:1,1,2 166:
318:2 334:22 head [3] 254:5 292:12 301:14 81:7 87:15 94:11 130:18 171: 14,14 169:5,6 171:10,12,13,
guide [2] 161:15 350:22 head-to-head [1] 273:2 7,17 206:9,20 207:20 214:14, 16 172:5,17 173:14,15,17
guideline [2] 31:2,4 headed [1] 200:14 15,21 228:14,17 233:22 264: 174:21 176:3,4 178:17,18
guidelines [3] 24:5 30:19 33: heads [1] 365:2 8 330:6 179:3 188:19,21 189:9 203:
15 HEALTH [9] 1:1 8:17,19 22:1 highest [5] 190:18 195:13 15 204:2,15,15 206:12 216:5
guides [1] 240:2 30:9 47:9 97:1 265:7,10 214:12 257:9 344:15 236:7 257:12,15,15,15,21
guiding [1] 293:18 healthy [8] 145:10 253:14 highlight [1] 54:8 258:3,3 259:5,6,7,8,11 272:
guinea [19] 67:8 101:11 112: 273:16 286:11 287:2 344:4 highlights [2] 52:11,17 10 283:19 284:19 286:14
7,18 113:1,7 134:4,6,21 136: 347:18 362:19 highly [4] 81:5 93:8 226:5,13 340:8 350:8 352:5 354:3 361:
1,3,8,18,19 140:5 214:2 315: hear [2] 63:13 280:15 hint [1] 65:15 18 364:11
5 321:16,20 heard [23] 110:12 111:19 113: hippocampal [4] 54:18 55: hours-plus [1] 216:9
guy [1] 253:8 15 114:2,15 117:5 167:4 181: 13 267:22 268:12 however [31] 10:18 25:6 34:
guys [1] 256:4 19 213:2 228:16 261:6 262: hippocampus [5] 95:20 257: 22 35:7 47:22 51:6 57:12 66:
Guzman [2] 2:10 3:26 18 263:18 265:21 307:2 308: 22 267:8,18 268:20 12 77:13 78:13 102:14 112:8
22 310:14 324:12 356:11 histological [4] 124:19 167:2 115:7 122:6 127:21 173:13
H 359:18 362:17 363:17 364: 171:2 268:18 175:22 187:2 188:20 190:14
H4 [1] 237:10 12 Histologically [1] 209:8 192:9 202:3 209:20 216:6
Haberny [1] 46:4 HEARING [14] 4:2 14:12,16 histology [1] 354:17 233:4 239:15 246:5 258:21
half [5] 134:11 136:3 150:14 50:11 89:17 218:2,4,6,10,15 histomorphological [1] 114: 268:18 282:6 299:18
167:12 269:2 250:14 266:15,17,18 16 Huafeng [1] 4:16
hallmarks [2] 111:3 114:16 heart [4] 109:20 134:14 137: histopathological [2] 11:19 Huda [1] 314:2
halogenated [1] 251:3 11 332:6 361:22 huge [3] 191:11 225:1 356:6
halothane [11] 28:15 144:15 heart-defect [1] 331:9 histopathologically [1] 50: HUMAN [53] 1:1 12:20 20:11
231:11 233:8,8,12,19,21 234: heavily [1] 39:3 14 25:5 26:8 30:9 47:8 48:20 49:
1 296:18 320:2 heck [1] 255:2 histopathology [3] 53:9 54: 4 73:2 76:6,22 83:11 92:20,
Hamlet [1] 183:17 Heights [2] 4:4 220:9 15 59:11 22,22 97:3,6 101:14 102:5,6,
hand [5] 39:20 214:18 292:11 hell [1] 254:2 historical [2] 41:19 345:2 8 104:3,7 110:19 111:7 162:
306:19 311:7 Hello [1] 6:17 History [9] 3:12 13:16 41:5,7 21 163:5,17 169:22 184:9
handed [1] 44:7 help [22] 46:18 72:14 125:14 234:11 273:11 302:20,20 186:9,17 187:19 189:5,7 192:
handle [3] 151:9 179:7 363:
HUMAN - infant

9 206:21 207:5,21 215:7 240: 137:19 143:3 150:21 153:1 22 54:4,9 59:16 61:16 68:5 77:18 79:18 89:11 109:1,1
20 241:15 269:5 276:2 282: 158:20 160:1 162:12,15 163: 74:9,21 75:7 80:1 96:22 102: 171:16 173:14 174:20 188:
14 294:6 310:18 314:15,17 12 164:20 167:11 176:17 4 115:13 116:1,4 117:16 131: 18 199:4 241:18 246:4 247:
315:6 316:5 318:12 177:3 179:14 181:22 288:16 13 148:10 153:10 154:11 13 259:17
humane [1] 201:16 293:18 294:4 300:5 342:4 155:6,7 189:17 199:19 200: increases [4] 25:6 207:4 236:
humans [37] 17:6 25:13,21 ideal [1] 304:4 11 201:18,20 204:9 205:4 11 332:11
26:5,10,18 55:19 56:14 57: identified [8] 33:18,20 40:2 208:3 209:19 211:7,10 212: increasing [6] 22:4 221:17
17 58:14 69:3 101:10,20 110: 49:2,2 79:12,15 107:13 13 213:18 218:12 221:14 235:15 246:6 248:3 263:2
11 112:7,11 133:16 146:16 identify [12] 33:22 34:8 38:16
233:9 235:13,16 245:10 247: incredibly [4] 125:1 135:15
191:4 193:5 199:21 202:3 56:5 80:6 98:15 270:19 306: 22 248:1,14 249:7 252:8,20 211:2,7
211:7,10 212:11 214:2,4 269: 19 325:10 346:14 362:7,13 261:5 267:13 275:13 283:15 incremental [1] 290:7
17 292:14 310:12 311:1 312: identifying [3] 78:10 290:4 285:13 287:14 290:9 297:9 incremented [1] 216:11
20 313:4,9 318:10 328:12,19 347:11 302:18 305:1,6 308:3 309:14 indeed [25] 46:9 51:19 75:13
humbly [1] 69:14 ignore [3] 211:19 212:11 324:318:6 319:17 322:7 325:10 129:21 139:20 149:21 174:2
hump [1] 254:17 9 327:9 331:21 332:22 334:1 185:14 186:8 187:3 189:18
hundreds [1] 226:8 II [2] 5:13 166:4 348:5,8 354:13 195:12 196:21 199:22 202:
hurdle [2] 254:14 364:19 III [3] 2:10 3:26 165:21 importantly [3] 118:8 187:5 16,19 213:18 214:20 216:1
hurt [3] 308:17,19,19 Ikonomidou [5] 11:4 42:3 59: 190:5 231:2,15 265:3 282:3 343:13
husband [1] 220:16 8 60:15 209:5 impress [1] 141:1 344:8
hybridization [1] 174:18 Ikonomidou's [1] 53:4 impressed [2] 251:17 337:21 independent [2] 143:12 237:
hydrate [1] 23:5 ill [3] 286:15 303:13 352:7 impression [1] 145:3 13
hydromorphone [1] 228:2 Illinois [2] 4:4 220:9 impressively [1] 140:9 independently [1] 84:15
hyperactivity [1] 105:22 illustrate [2] 52:22 97:22 improve [1] 208:11 indicate [4] 93:13 169:12 240:
hypercarbia [2] 302:13 304: illustrates [2] 43:4 55:17 improved [4] 32:6 227:7 258: 22 285:15
1 illustrating [1] 98:7 21 259:9 indicated [3] 50:11 186:5
hypercarbic [1] 120:10 IM [2] 135:22 166:18 improvement [2] 107:15 259: 187:22
hypercardia [1] 242:20 imaged [1] 275:5 2 indicates [2] 19:3 80:2
hyperglycemia [1] 185:5 imaging [12] 165:19 274:2,19improvements [1] 243:1 indicating [1] 237:11
hyperperfusion [1] 121:14 improving [1] 249:10
290:4 349:3 359:22,22 360:7, indication [5] 22:3 33:17 34:
hypertensive [1] 253:15 17,21 361:6,6 impulses [1] 193:17 4 173:7 350:7
hypertrophy [1] 82:3 immature [2] 97:3 193:17 impulsivity [1] 316:20 indications [6] 13:18 23:13
hyperventilation [1] 184:15 immaturity [1] 110:5 in-situ [1] 174:17 32:21 210:21 247:16 351:10
hypervolemia [1] 121:15 immediate [7] 227:9,12,14, in-utero [5] 112:12,19 113:3, indicative [3] 43:21 158:5
hypnotic [4] 19:13 22:7 242: 21 228:8,10 337:16 9 134:8 299:15
16 247:20 immediate-release [1] 228: in-vitro [1] 160:14 indicator [5] 167:3 172:12,15
hypnotic-agent [1] 242:18 13 inactivate [1] 97:18 173:7 356:15
hypnotics [1] 34:16 immediately [3] 91:18 159: inadvertent [1] 228:17 indicators [1] 290:2
hypocapnia [2] 235:22 239:6 17 160:3 incidence [9] 38:3 64:6 244: indirect [1] 197:8
hypocarbia [1] 120:3 immunocytochemistry [1] 17 247:7 262:4 264:11 272: individual [12] 14:7 18:10 22:
hypocarbic [2] 119:21 120: 80:20 17,20 316:20 1 67:16 77:14 88:11 89:2
10 immunohistochemical [1] incision [1] 190:12 215:21 223:8 322:22 335:18
hypoglycemia [5] 91:4,7,14, 80:5 include [8] 22:8 30:22 47:15 341:20
15 92:11 immunohistochemistry [1] 83:13 137:17 218:21 248:19 individual's [1] 218:13
hypoglycemic [1] 91:8 80:13 290:15 individually [4] 63:16 87:19
hypotension [1] 185:8 immunosuppression [1] included [7] 54:15 88:12 119: 297:18 300:20
hypothermia [3] 291:16 329: 323:15 16 139:21 198:18 221:1 328: individuals [5] 45:13 125:1
16,18 impact [15] 14:1 15:3 17:12 4 362:8,13,14
hypothermic [2] 291:20,20 44:9 56:20 225:3 229:4 235: includes [2] 28:1 290:13 induce [19] 86:10 90:17 104:
hypotheses [1] 349:9 5 244:5 248:21 269:10 316:4, including [12] 11:5 19:21 29: 1 106:17 160:16 207:16 236:
hypothesis [7] 92:16 162:7 22 349:4,5 15 45:9 185:6 186:17 193:12 8,15,18,20 237:9 238:13 239:
234:2 242:12 257:8,20 273:4 impairment [6] 144:9 262:5, 215:7 240:19 254:20 271:4 8 253:5 255:15 257:4,21 260:
hypothesize [1] 241:7 11 264:19 265:4,22 338:17 3,6
hypothesized [1] 257:3 impairments [4] 19:22 55:14 inclusive [1] 22:20 induced [5] 14:2 186:21 187:
hypothesizing [1] 230:10 144:17 145:17 incompatible [1] 205:17 4 237:5,12
hypoventilated [1] 119:22 Implement [1] 223:13 inconceivable [1] 108:9 induces [1] 90:2
hypoxia [5] 120:3 235:22 239: Implementation [1] 30:1 incorporate [2] 307:4 364:7 inducing [1] 19:15
6 302:12 304:1 implicated [6] 55:2 66:20,21, increase [52] 64:2,5,10,12 85: induction [7] 141:15 143:8
hypoxia/ischemia [5] 89:21 22 67:4 231:16 22 86:12,15 87:2 89:4,6,9,13 174:19 175:1 188:9 250:3
90:3,14,16 91:7 implication [1] 183:8 92:9 103:22 122:13,21 129: 326:20
hypoxic [3] 119:21 120:9 301: Implications [10] 3:24 16:14 15 130:8 131:3 138:6,7,13 Industry [7] 2:14 8:22 9:19,
19 47:17 57:21 83:10 97:1 140: 150:9,16,18 154:7,9 155:10, 20,22 33:11 99:2
21 183:2,3 193:3 11 157:7 171:19 172:11 173: ineffective [1] 26:16
I importance [8] 42:15 74:13 2,15 175:1,17 176:2,5 177:15 infancy [1] 316:9
ICU [15] 22:20 189:11 271:11, 154:12 174:16 221:16 326:1 188:17 235:5,8 236:12,16 infant [17] 21:2 77:10 80:10
22 286:16 308:8,9 317:5 323: 328:2 350:4 237:5 238:15,15,18 247:21 86:13,19 88:3,15 90:17 91:6,
13 334:1 346:18 347:4,13 important [78] 13:10,22 15: 268:20 321:18 357:18 17 92:12 153:20 194:8 273:
348:7 362:21 10 23:7 30:15 48:22 53:16, increased [16] 18:19 50:17 16 279:10 331:10 347:16
idea [23] 107:6 109:16 112:4
infants - January

infants [15] 35:21 47:18 186: input [4] 33:13 45:15 341:12 international [2] 200:10 322: 160:22 193:21 195:7 199:16
1 187:17 197:12 198:5 200: 365:11 3 216:8 221:6 225:9,12 240:16
21 279:19 283:17 287:2 307: inquest [1] 220:20 internist [1] 225:10 involvement [2] 10:8,12
18 344:4 361:17,18,21 inside [3] 126:12 171:8 338:5 interpret [8] 58:3 59:3 68:1 involves [4] 10:4 148:11 241:
infarctive [2] 277:2,2 insights [1] 69:12 72:15,16 206:13 301:12 342: 15 363:8
infected [1] 276:19 insistent [1] 219:15 8 involving [3] 9:10 78:6 247:9
inference [1] 347:3 insofar [1] 222:14 interpretation [2] 56:21 163: IP [1] 342:12
inflammation [1] 18:13 instability [1] 196:7 16 IQ [2] 104:15 348:10
inflammatory [1] 115:16 instance [1] 43:22 interpretations [1] 68:12 irrefutable [1] 201:22
influence [5] 17:17 245:12 instances [1] 20:22 interpreted [3] 24:6 46:22 58: irrelevant [1] 213:22
248:10 291:21 294:1 institute [1] 291:15 17 ischemia [7] 51:16,22 259:16
influx [2] 161:17 176:20 institution [4] 186:1 197:11 interpreting [1] 153:12 260:5,6 324:2,16
inform [1] 248:14 200:16 352:1 interrogate [1] 301:9 isn't [3] 103:17 204:4 320:1
information [41] 13:21 15:18 institutions [3] 201:11 272:3 interval [1] 204:1 isobole [1] 337:8
19:2 20:16 23:12,18 24:10 360:20 intervals [3] 151:14 241:9 isobolographic [1] 337:4
27:11 36:1 39:19 49:20 52: instructive [1] 356:18 277:20 isoflurane [76] 19:10 30:17
12 53:1 65:13 66:8,14 67:8,9, insults [3] 51:7 239:6 357:2 intervening [1] 332:12 54:14,21 88:10,12,15,17 89:3
18,20 68:2,8,13 69:10 72:17 intact [1] 115:6 intervention [3] 68:22 144:6 90:11 91:6,9,11,13 92:2,3,4,
153:10,15 158:17 218:9,20 integrated [1] 301:10 364:4 4,8 118:12 136:2 137:17,19
252:22 261:12 262:19 266:5 integration [2] 276:14 349: interventions [4] 21:21 144: 138:7,19 213:4,16 214:2,3
274:11 308:2,21 309:16 311: 10 3 273:13 287:8 231:12 233:5,5,12 235:1 236:
12 341:18 365:10 Intelligence [2] 345:22 348: intoxication [1] 86:4 3,6,15,18,20 237:6,8,12,18,
informed [1] 29:15 12 intracellular [2] 97:19 98:5 20 238:12,22 239:2,16 251:1
informing [1] 24:1 intensive [4] 16:21 197:4 intraoperative [1] 271:20 257:1,4,10,16,20 258:1,4,19,
infused [3] 95:3 166:12 216: 213:3 291:15 intraperitoneal [1] 53:8 21 259:4,8,11,14,18 260:11,
10 intensive-care [2] 135:17 intraperitoneally [1] 88:3 14 263:1 284:19 294:21 296:
infusion [14] 94:3,4 99:10,14 212:20 intravenous [9] 36:1 117:3 14,15 297:12 298:3 318:18
135:13,19 138:14 166:18 intensivist [2] 7:19 271:10 134:17 190:17 250:17 251:8 320:2,16 335:15
188:22 212:22 321:19 340: intensivists [1] 287:8 253:6 255:16 256:2 isoflurane's [1] 233:13
19,20 347:21 intentionally [1] 90:17 intravenously [2] 95:3 166: isoflurane-induced [5] 236:
infusions [8] 197:16 271:11, interact [3] 106:15 233:1 336: 12 13 238:6,9 256:16,19
12,14 272:17,21 332:1 340: 15 intraventricular [2] 185:8 isolated [7] 202:12 230:15
16 interacted [1] 98:3 273:6 316:13 341:13 342:3,6 347:
ingredient [1] 88:13 interaction [3] 227:1 246:15 intrigued [1] 288:22 15
inguinal [3] 200:20 286:12 337:13 intrinsic [4] 79:15 128:22 isolation [1] 334:16
287:2 interactions [3] 181:21 242: 129:1 298:22 Israel [1] 64:16
inhalation [2] 236:3,17 16 336:11 introduce [2] 5:6 84:19 issue [51] 9:5 39:20 72:4 84:
inhalational [6] 117:3,11 213: interagency [1] 47:6 introduced [1] 28:16 19 106:9 107:5 121:4 180:13
10 250:9,18 253:1 intercellular [1] 98:20 introducing [1] 167:10 183:12 189:4 191:13 193:8,
inhaled [17] 19:14 22:7 34:17 intercept [1] 97:18 introduction [1] 219:19 20 194:1 199:19 200:1 202:
194:4 213:13 229:10 230:10, Interest [13] 3:4 9:2,3,5,16 10: Introductions [2] 3:2 5:2 12 204:10 219:6 224:6 244:
17 257:4 318:18,19,20,20 7,11 84:7 147:1 182:17 239: Introductory [2] 3:7 10:22 12 261:20 268:1,2,3 269:13
320:7 324:14 328:21 355:20 21 292:12 294:11 intubate [1] 134:14 272:4 275:13,19 279:3,6 294:
inherent [1] 260:4 interested [11] 102:16 156: intubated [5] 252:16,18 271: 18 320:18 323:3 324:13 325:
inhibit [1] 116:21 16 165:18 260:21 265:13 15 273:19 347:17 8 326:4 328:2 330:9 331:19,
inhibited [3] 98:4 100:20 258: 277:6 307:3 314:9 318:2 359: intubating [1] 190:10 21 332:4 334:18 335:3 336:
2 5 361:12 intubation [1] 273:17 15 338:6 344:15 356:13 357:
inhibition [1] 116:21 interesting [36] 19:17 32:18 invest [1] 357:14 17 362:12 365:7
inhibitor [1] 107:14 42:7 51:17 61:9 62:21 69:19 investigated [2] 202:4 325: issued [4] 30:19 31:1 33:12
inhibitors [1] 237:17 73:19 134:6 141:19 145:1 14 223:9
inhibits [2] 242:1 259:5 150:11 151:16 152:14 170: investigation [1] 326:4 Issues [20] 3:9 16:4,7,17 149:
initial [11] 39:5 57:22 127:4 12 172:8,10,21 174:1,21 179: investigational [3] 26:9,21 10 156:20 181:2 225:8,13
148:5 163:20 178:14 181:8 22 206:15 214:11 215:10 29:14 244:13 256:2,5 265:8 285:7
247:2 268:18,19 272:14 251:21 252:14 269:13 288: investigations [2] 45:19 293: 289:9 302:13 304:7 327:8
initially [5] 57:16 85:3 146:1 17 289:6 292:19 294:14 350: 2 338:16 359:17
166:17 233:11 20 351:4 353:9 355:6 358:14 investigator [2] 260:20 345: item [1] 9:1
initiated [3] 12:7 29:22 248:9 interestingly [4] 61:22 64:4 4 items [1] 287:17
initiating [1] 348:17 138:8 246:19 investigators [11] 13:7 14:8 itself [11] 50:14 59:1 69:8 141:
Initiative [1] 183:8 interests [4] 9:12,14,22 220: 52:14,20 68:10 73:18 193:19 17 148:16 160:19 190:7 197:
initiatives [2] 198:12,18 4 208:2 291:14 325:15 358:18 3 231:4 336:3 363:7
inject [1] 284:5 interfere [4] 75:6 97:17 98:20 investment [2] 333:1 357:4 IV [3] 33:6 165:21 253:3
injecting [1] 284:7 241:20 invited [2] 9:18 11:2
injection [3] 53:10,11 340:4 interim [1] 277:7 inviting [2] 74:8 183:7
J
injections [8] 42:19 44:4 53: intermittent [1] 347:21 involve [3] 50:10 177:22 246: Jackson [5] 4:3 219:18,21,22

8 59:11 340:5,6,15,22 intermixing [2] 79:5 115:9 9 220:6
injury [7] 68:20 107:11 193: internal 78:18 190:12 253: involved
[3] [17] 39:9 45:2,13 54: James [1] 2:7

20 195:22 197:6 324:2 359:9 17 6 80:16 149:16,16 158:12 Jane [1] 345:22
January [1] 38:15
Japan - life-threatening

Japan [1] 117:12 21 172:18 173:13,14 174:20, labeled [3] 39:14 80:12 138:2 leaky [1] 129:9
jar [1] 133:6 22 175:19 176:4 177:14 178: labeling [2] 24:4 138:6 learn [4] 165:16 211:12 262:
Jayant [2] 2:18 7:5 6,16 181:17 187:3 188:8,14 labels [2] 23:12,18 15 357:8
JCAH [1] 331:3 189:8 191:4 207:10 213:1 labor [1] 21:14 learned [6] 63:1 128:1 212:2
Jeff [1] 8:15 214:22 216:18 271:11,12 laboratory [10] 45:2 149:13 298:18 307:12 349:18
Jeffrey [1] 2:20 272:7 288:10 298:14 303:20 201:22 202:15 229:9 230:16 learners [2] 128:15 262:16
Jevtovic-Todorovic [27] 2: 304:6 318:11 319:2 320:1 245:15 260:20 262:8 306:6 learning [21] 55:14 62:10,18
19 3:19 6:13 108:4 209:3 322:2,4,15 337:19,21 338:8 lack [9] 73:12 82:4 189:16 105:22 126:5,19 128:13 145:
214:7 267:14 269:12 283:11, 340:1,4 341:7 349:9 221:10 263:20 283:19,20 8 256:21 257:1,6 258:9,14,15,
13 295:6,10,14 297:19 299:5 ketamine-exposed [1] 172: 309:16 311:12 19 259:12 263:14 265:4 290:
300:16 301:14 302:5 312:8 18 lacking [1] 263:17 16 296:16,18
313:20 321:9 326:18 338:19 ketamine-induced [4] 12:9 landmark [2] 11:6 184:18 learns [1] 262:14
351:12 353:22 354:6,11 65:20 177:17,22 laparotomy [1] 196:15 least [33] 39:9,18 56:8 75:5
Jevtovik-Todorovic [1] 74: ketamine-treated [5] 95:12, large [11] 15:5 44:12 50:6 72: 77:5 104:20 105:2 128:22
15 18 99:17 169:3 173:17 1 93:9 104:2 134:10 187:19 133:12 146:15 159:12,20
Jim [2] 6:10 337:2 key [6] 28:2 116:1 308:12 314: 247:10 320:5 353:5 160:20 206:9 208:16 214:13
job [1] 167:9 13 338:6 342:21 largely [3] 110:5 262:20 265: 229:14 231:13 233:14 241:
John [17] 2:27 3:16 4:13 11:5 kid [2] 143:3 306:16 20 17 261:10 262:12 281:13
42:5 74:3 101:21 149:8 165: kids [31] 110:2 133:6 141:22, larger [3] 91:12 99:16 139:12 284:6 300:9 323:2,4 338:22
4 172:2 181:2 203:12 205:12, 22 142:5 143:11,13,16 144:1, largest [1] 265:6 339:14 340:14 350:12 354:4
17 247:5 249:16 304:13 6,11,14 145:10 224:11 252:8, laryngeal [1] 252:17 363:12
Johns [1] 6:5 13 301:16 303:8,11,13,20 laryngospasm [2] 109:18 leave [2] 66:12 278:1
join [1] 185:10 304:5 305:19,21 310:15 327: 252:11 leaves [3] 338:1,2 340:1
joined [1] 16:11 15,17 332:6 346:8 354:4 355: laryngospastic [1] 252:7 led [1] 44:18
joining [2] 6:20 48:3 3 laser [1] 121:6 left [6] 82:2 120:15 123:18
Journal [5] 185:17 198:21 killed [4] 28:6 171:10 220:17 last [39] 17:4 22:22 33:10 53: 124:7 270:6 348:6
199:6 306:11 314:3 224:11 9 72:18 73:11 85:7 97:21 legal [1] 86:4
journals [1] 282:7 killer [1] 220:18 106:2 108:4,14 110:16 111: lend [1] 363:7
Jr [2] 2:31 3:23 killing [1] 222:20 20 112:11 148:1 151:17,17 length [1] 164:1
judge [1] 203:18 kills [1] 90:19 153:2 182:7,20 201:5 206:4 lengthy [1] 45:6
Julia [1] 2:22 kilo [1] 134:11 214:8,9 225:13,22 246:12 lesions [1] 196:2
Julie [1] 8:2 kilogram [1] 167:12 259:2 260:17 281:20 286:13 less [15] 21:20 35:13 38:17
jump [4] 87:3 102:7 152:9 kind [41] 80:17 106:10,18 107: 290:22 314:4 324:12 340:4,7 108:18 123:10 131:9 192:13
154:9 5 115:12 120:1,7 127:9 129: 351:18 364:2,3 250:15 251:5 264:5 286:13
jumps [1] 170:15 8 136:20 149:17 157:13 158: lasting [2] 262:11 266:4 320:2 339:18 340:15 350:19
juvenile [10] 11:7 12:8,15 14: 13,13,17 172:7,10,15,21 178: Lastly [2] 26:17 38:2 lesser [1] 335:6
3 19:8 33:7 211:11 258:16 18 205:14 206:2 207:14 250: lasts [1] 159:20 lessons [1] 307:11
259:10 261:7 10 251:5 252:5 254:13 260: late [5] 103:7 220:19 245:6 letting [2] 140:2,3
juveniles [2] 11:21 258:22 13 264:17 265:17 274:18 248:21 275:19 leukemia [1] 72:3
276:21 278:3,20 284:13 302: lately [1] 320:11 level [39] 24:10 60:22 64:8 70:
K 5 318:3 326:9 337:22 339:16 later [37] 5:14,16 22:12 25:2 2 78:4 86:3,5 94:5 129:9,15,
Kanwaljeet [2] 2:6 6:20 359:3 30:4,17 31:22 36:7 39:3,6 48: 16 151:21 165:5 174:10 190:
keen [1] 346:16 kinds [18] 148:12 150:20 157: 4,4 49:9 78:2,20,20 101:15 9,11 204:22 211:18 215:6
keep [10] 141:16 152:18 153: 19,20 165:12 169:11 171:4 109:13 115:7 117:11 119:7 216:2,12,15 221:22 227:3
11 213:3 273:9 322:1,7,13 175:14 181:2,6 205:10 289: 120:18 133:7 135:1 142:10 229:4 254:16 263:12 278:18
345:12 353:21 13 290:2 291:5 356:21 359: 154:22 159:19 178:12 193: 293:10,16 300:4 327:13 337:
keeping [2] 28:22 219:15 10 361:2 362:3 15 196:14 213:19 301:2 305: 8,9 338:10 339:14 340:17
Kefauver-Harris [1] 29:2 Kirk [1] 219:20 15 323:7 332:10 336:11 338: 344:21 349:13
Kelley [5] 4:11 243:17,18 249: Kirsch [12] 2:20 8:15,16 73: 3 levels [43] 58:2,15 59:17 60:2,
12 298:11 11,12 281:19 311:18,19 312: laughing [2] 83:15 117:9 5,11,19 61:2 73:7 78:4 85:21
Kelsey [1] 28:21 21 313:1 323:16,17 law [1] 28:10 91:20 92:1,6 94:4 99:13,20
kept [3] 284:10,12 319:4 knocking [1] 141:12 laws [1] 30:11 105:18 129:22 149:16 151:3,
ketamine [138] 11:14 19:10 knowing [2] 128:11 302:22 lawyers [1] 37:5 10,19 152:1,16 153:1,3,9,22
30:4 38:14 42:17 44:3,15 47: knowledge [6] 13:11 15:3,19 layer [5] 87:8,8 95:12 96:10 155:12 167:20 173:8 178:3
2,14,19 50:7 53:12,18,20 54: 221:10 304:18 364:8 124:13 206:19 207:19 214:21 215:7
12 58:6 59:13,15,18,22 60:4, known [13] 18:15 73:14 74:22 layers [2] 81:6 96:6 233:18 236:4,11 354:2 360:
9 61:1,2,12,13,20,22 62:7,12, 83:13,14 118:7 140:21 141:2 LCDR [4] 2:3 3:5 6:17 9:4 13,14
12,22 63:4,15,17,19,22 64:11, 207:6 218:19 240:21 278:15 LDH [2] 158:5 161:1 Levy [1] 141:6
17,20 66:3 69:20 73:8 83:13 327:20 lead [5] 106:6,15,16 308:18 Lewis [2] 4:10 239:19
86:7,9,12,14,16 87:11,15,18 KO8 [1] 256:12 339:15 licked [1] 283:21
90:1,6 93:7 94:21,22 95:3,16, leaders [1] 15:12 LIFE [24] 1:4 2:4,12 5:4 9:9
21 96:17 99:9,11,14,20 117:5, L leading [5] 17:20 43:14 53:1 17:5 21:22 37:3 48:21 110:
10 144:15 147:13 149:21 lab [11] 114:18 117:8 118:5 129:11 332:5 19 111:22 112:12,13,17 113:
151:3 152:17 153:9,22 154:6, 124:16 213:15 256:15 267: leads [2] 193:14 299:17 3,9 196:14 224:4 240:3 254:
20 155:10 156:3,10 157:9 17 281:22 287:22 295:17 leak [2] 79:19 130:17 8 316:16,19 324:4,8
159:6,8 160:10,16 161:16,19, 314:3 leakage [2] 130:9 131:2 life-long [2] 331:18 332:5
22 165:14 166:13,18 167:20 label [4] 24:1 27:12 31:8 223: leaks [1] 129:9 life-threatening [3] 20:20 26:
168:14 170:2,5,14,21 171:15, 3
life-threatening - markedly

14 36:11 181:13 185:6 207:6 211:13, 269:14 275:15 278:3 281:1 mainly [5] 111:10,21 115:2
lifesaving [1] 195:16 16 212:12 231:3 259:16 260: 282:13 290:17 296:11 298: 141:7 142:18
ligand [3] 270:16,18,19 2,2 265:9 271:17 309:4 315: 11,13 304:22 314:22 320:8 mainstay [1] 322:17
ligation [1] 185:1 14 326:21,22 346:19 328:20 336:10 341:7 343:7 maintain [12] 95:5 146:5 164:
light [11] 81:11 95:4 146:13 long-acting [2] 227:6 281:21 344:2 345:16,17,19,20 346:3 1 165:6 166:13 169:12 170:
165:4 166:13 172:19 186:2 long-bone [2] 188:13 322:17 348:10,13 349:18 356:14 14 214:22 216:2,11,15 292:8
205:10 219:11,12,13 long-lasting [9] 179:19 260: 358:2 359:14 363:6 maintained [1] 151:21
lights [2] 170:22 219:10 22 261:10,16,17 263:7 264: looks [9] 77:10 80:22 87:7 94: maintaining [1] 94:4
likely [10] 21:19 30:20 37:12 19 265:16,22 12,14 167:14 173:16 215:11 maintenance [4] 143:8 240:
38:5 93:14 107:3 206:5 221: long-term [31] 47:17 63:5,9 363:15 17 250:3 326:20
4 279:7 324:17 67:11 97:15 119:1 144:9 145: loop [1] 255:8 major [11] 60:5,21 73:7 92:14
Likewise [1] 219:2 5,7,17 146:11 179:21 199:20 Lortabs [2] 226:9,10 148:9 170:20 265:9 314:5
limbic [2] 101:16 267:8 202:3 223:13 244:22 245:13 lose [1] 114:6 316:6 320:7 363:17
limit [3] 222:10 223:4 287:3 248:10 251:20 255:2 256:2 loss [1] 257:1 majority [6] 11:15 110:20
limitations [4] 15:18 36:22 274:13,19 276:10 277:1 282: lost [2] 128:9 220:16 116:14 141:9 307:16 351:20
121:1 132:18 13 283:1 286:16 329:3 331: lot [48] 39:19 49:19 51:19 54: male [1] 73:15
limited [9] 20:20 27:13 33:4 18 348:1 7 55:16 57:7 111:13,14 114: malformation [2] 21:11 195:
34:7 38:10 65:9 146:9 222:2 longer [8] 49:4 93:5 136:9,11 7 117:5 119:17 121:1 124:19 1
326:8 139:3 144:12 162:1 300:22 127:22 132:17 133:22 135:9 malformations [2] 105:7
limiting [1] 335:11 longer-term [1] 359:11 144:2,2 149:9 167:5,13,14 197:1
line [9] 19:18 34:3 134:16,17 longitudinal [1] 290:5 173:16 174:12 178:21 192: malformed [1] 21:8
169:16 170:4 253:6 255:16 look [101] 13:2 14:15 32:20 22 193:12 208:17 210:2,2,17 mammalian [3] 113:5 315:1,
318:1 34:15 55:18 56:6 58:11 78: 267:9 275:16 276:6 298:18 2
lines [3] 136:17 323:10 341: 14 79:4 94:8 101:14 113:4 303:11 306:9 310:16 320:11 man [2] 192:1 228:19
15 120:6 122:22 123:18 124:1 325:18 328:15 340:18 343: manage [1] 187:12
link [1] 289:9 129:4 130:9,19 136:6,16 150: 20 346:2 351:11 356:3 365: manageable [1] 326:22
linked [2] 144:17 274:12 6 152:4 154:1 157:5 158:8, 10 managed [1] 127:20
links [1] 274:18 19 159:1,2 160:2 164:5,18,22 lots [1] 101:6 management [5] 183:22 197:
list [16] 82:15 106:16 109:14, 165:2,9,12 169:19 174:17 lottery [1] 305:3 4 271:20 309:1 331:2
21 309:10 319:4 322:2,7,13 176:11 179:22 183:22 192:4, loud [1] 352:15 managing [1] 253:22
326:19,21 327:2,3 328:7 329: 7,14 196:11 199:17 200:20 Louis [1] 84:22 mandated [1] 32:9
12 333:20 202:17 205:11 207:2,8,11 love [2] 255:4,6 mandatory [1] 223:10
listed [8] 19:18,20 74:12 109: 209:8,20 215:21 231:7,8 232: loving [1] 224:1 manifest [1] 160:19
10 117:2 137:18 322:10 328: 20 234:8,10 246:8 248:17 low [8] 138:14 153:9 156:3 manifestations [1] 275:21
4 262:1 264:3 268:19 274:3 259:20 279:22 321:19 335: manifesting [1] 50:14
listen [1] 148:2 276:17 282:16 285:12 289: 15 336:4 manipulate [4] 116:17,18
lists [1] 289:22 14,22 297:9 298:10 302:18, low-level [1] 301:1 117:20 131:18
literature [11] 41:14 45:22 52: 19 305:6 314:2 318:17 321:2 LTP [3] 268:6,14,15 manipulated [1] 242:17
7 58:1 65:14 66:15 67:6 146: 325:22 327:9 328:16 329:1 lumbosacral [1] 278:9 manipulation [1] 190:12
11 228:6 240:7 317:1 337:8,13,17,21 338:11 347:7 lump [2] 122:16 296:8 manipulations [1] 196:8
litigation [1] 30:14 348:9 354:9 355:11 357:7,11 lunch [4] 14:10 203:6 214:9 manner [4] 97:7 223:17 244:
little [33] 39:2 48:4 63:14 94: 358:9 359:16 360:9,15,21 216:20 19 361:21
10 113:19 120:11,22 126:22 362:20 363:21 luxury [2] 126:2 258:11 manufacturers [4] 29:5 30:
127:3 128:2 141:1 146:14 looked [59] 37:17 38:19 51: lymphoma [1] 246:13 20 31:15,18
152:20 171:17 176:1 177:19 20 52:7 59:17 60:2 72:6 107: manufactures [1] 244:1
179:14 212:22 213:8 230:14 11 121:21 123:2 130:3,15
M manuscript [1] 169:17
231:13 233:21 249:6 263:8 131:21 137:9,10 138:17 141: M.D [34] 2:2,6,7,8,9,10,11,14, many [59] 12:17 19:5 21:21
265:21 267:12 274:1 279:5 7 144:13 159:17,18 164:12, 17,18,19,20,21,22,23,25,27, 22:18 28:7 39:14 40:2 45:20
297:6 339:3 341:4 344:3 345: 14,16 168:6 172:2,14 184:20 29,30,33 3:3,8,11,16,19,26 4: 55:20 56:2,4 75:6,7 78:11 79:
14 185:12 194:12,17 196:13 5,7,9,10,11,13,16,18 13 80:11 81:19 82:5,19 83:
live [2] 224:8 270:6 197:17,21 232:11 272:2 274: MAC [3] 88:15 295:4,20 10,18 84:1 95:18,18 96:18
liver [1] 246:14 9 275:19 280:19 288:12,18 machines [1] 251:11 115:21 128:6 131:2 135:17
Liverpool [2] 184:12 185:2 292:16 295:11 299:2,6,9,21 made [14] 9:6 33:22 136:20 138:6,6 139:10 144:5,5,5
lives [2] 224:3,8 300:11,20 301:20 316:12 157:22 186:14 221:7 270:5 145:3 148:9 167:15 178:21
loaded [1] 180:9 317:2 324:5 326:14 327:22 273:21 283:14 300:19 317: 181:3 194:2 195:21 196:12
loading [2] 165:10 291:11 329:7 353:19 354:1 359:6 14 336:16 350:3 355:21 198:13 224:3 226:8 236:19
local [14] 21:16 22:8 34:19 35: 363:16 magnesium [15] 329:11,14 237:2 242:21 246:9 276:17
3 67:2 279:22 281:1,8,10,21 looking [73] 54:11 66:1 67:21 350:4,6,11,14,15,20 351:1,8 279:7 296:19 303:2 307:6
321:21 327:11 329:1,8 71:21 73:6 81:15 100:11 107: 352:15 353:1,2,3 363:6 310:1 331:22 350:8 351:15
locate [1] 145:6 10 113:7,8 120:2 128:4 142: magnetoencephalograph March [3] 1:6 256:11 294:17
locations [1] 241:9 16 150:6 151:13 152:8 157:4, y [1] 360:19 margin [3] 60:12 73:9 97:14
lodging [1] 218:22 6 158:11,21 160:2 164:11 magnification [4] 77:12 81: margins [1] 72:22
Loepke [3] 88:14 90:10 91:5 168:8,13 170:2 173:6 174:16 20 94:11 139:12 Marin [1] 249:18
logical [1] 242:7 176:8 179:3 191:19 195:5 magnified [1] 78:16 Mark [1] 219:19
long [29] 85:4,20 86:2 104:12 196:1 197:8,12 200:13 206:3 magnitude [2] 77:18 339:5 marked [3] 16:21 43:19 275:7
108:17 112:20 116:13 119:4 211:15 215:18 230:16 231:7 main [8] 115:22 126:3 144:14 markedly [3] 18:19 105:17
127:10 141:4 143:20 169:13 234:5 246:22 264:2 265:7 177:8 229:9 249:21 279:3 155:15
302:7
markers - MK-801's

markers [3] 180:12 290:5 360:2 363:19 290:15 296:17,19 mid-term [1] 179:12
361:22 measured [6] 99:20 100:13 mental [2] 105:12,15 midazolam [28] 19:10 30:17
market [8] 28:17 29:1 32:10 137:6,8 247:20 285:9 mention [5] 61:7 71:6 83:7 54:15,22 63:15,18,19 64:10,
222:17 223:2 226:20,22 227: measurement [1] 354:15 84:6 128:19 11 87:18 118:15,16 124:10
4 measurements [5] 90:5 104: mentioned [19] 59:1 65:12 135:22 137:18 138:19 208:
marketed [4] 27:18 28:4,17 6,16 167:16 340:3 66:7 69:3 87:3 166:9 216:2 10 271:13 272:6,16,21 273:1
29:13 measures [4] 195:6 197:8 235:20 239:2 253:16 266:20 284:8 303:21 304:12 332:1
marketing [11] 26:10,21 27: 274:7 328:12 270:9 279:15 293:10 298:8 347:6,21
22 28:2,9,13 29:7,12 31:15 measuring [5] 104:10 190:1 303:3 306:8 320:16 329:19 midazolam/fentanyl [1] 212:
32:2 33:4 200:7 342:20 346:15 meperidine [1] 28:16 22
marking [1] 80:5 mechanical [2] 273:13,18 Merle [1] 291:1 midway [2] 113:2 140:10
Mary [2] 200:15 345:20 mechanically [1] 134:15 message [2] 233:10 297:8 might [33] 14:18 15:1,3 70:6
Maryland [1] 1:11 mechanism [32] 18:16 79:10 messages [1] 226:2 103:11 106:15,22 149:12
mask [3] 141:15 143:4 252:17 106:7 107:1,2,3 116:12 181: messy [1] 297:6 198:4 243:7 255:10 261:21
Mason [1] 8:3 4 209:1,22 212:3 214:16 215: metabolic [3] 35:21 56:12 279:20 289:5,8 294:5,7 310:
mass [3] 77:6 82:10 245:15 2 240:4,17 241:4,13 242:11, 185:5 7 323:20 328:12 329:11 335:
Massachusetts [1] 4:9 21 243:4,8 282:13 288:3 289: metabolism [5] 191:8 215:5 16,18,20 346:20 349:21 351:
massive [8] 111:10 112:14 5 294:16 313:7 337:15,17,20 239:7 294:2,8 4 356:7 361:2,22 362:7 363:
115:15 150:18 194:9,10 269: 338:15,21 339:14 metabolite [2] 56:14,15 16 364:18
18 296:18 mechanism-related [1] 361: metabolites [1] 170:21 migrate [2] 111:14 113:13
master [1] 127:21 2 metabolized [1] 191:8 mild [6] 20:4 105:21 106:1
match [2] 315:3 351:7 mechanisms [16] 70:9 72:14 metabonomics [1] 289:13 150:16 242:19 291:19
matched [1] 148:20 150:10 229:17 245:17 266:9 metastases [1] 246:14 milestones [3] 74:22 75:2,7
material [1] 208:19 281:7 282:20 283:3 288:12 methadone [4] 322:9,12 323: milieu [1] 111:11
materials [1] 243:11 293:21 294:3 325:14,22 336: 1 329:1 military [2] 107:9 301:3
Maternal [6] 20:19 62:16,22 19 338:22 method [5] 43:10 80:9 81:1, millennia [1] 76:21
91:19 258:6 350:13 mechanistic [2] 46:21 336: 11 348:18 milliliter [1] 159:10
maternal-positive [1] 257: 20 methodologies [1] 336:11 million [5] 235:7,9,18 264:6
19 mechanistically [1] 296:14 methodology [3] 336:9 348: 287:15
mathematically [1] 138:11 meddling [1] 116:8 14 349:7 mimic [3] 55:5 57:3 136:5
matrix [1] 78:18 mediated [1] 300:11 methods [2] 70:2 79:11 mimicked [1] 57:11
matter [11] 9:8,10 123:10 272: mediating [1] 72:14 methohexital [1] 28:16 mimicking [1] 133:9
20 273:6,22 274:14,17 275:7 Medical [18] 4:9,12,14,18 6:1 metric [1] 100:3 mind [11] 97:10,22 106:5 141:
287:6 305:13 7:10,15 8:12 22:3 28:22 227: metrics [2] 232:10 331:3 16 152:18 153:11 204:4 265:
matters [4] 125:9 212:17 263: 17 228:22 243:2,22 249:16, Meyer [2] 2:29 5:12 17 273:9 282:19 357:20
22 266:3 21 302:19 343:15 mg [1] 136:3 minds [1] 287:15
Mattison [8] 2:21 8:14,14 medication [2] 31:2 221:1 mg/dl [2] 86:2,5 minimal [2] 85:8 88:16
199:16 203:10,11 311:20 medications [9] 21:3 32:7 mg/kg [32] 42:18 44:3 59:14, minimize [3] 222:18 242:17
313:2 57:7 208:14 241:18 326:19 14,15,22 60:9,16 61:12 63:18 286:3
mature [2] 111:15 240:21 327:3,15 335:10 64:1,2,21 69:20,20 86:17,20 minimized [1] 20:10
maximal [2] 82:7 130:17 Medicine [6] 6:4 110:1 116: 87:1 88:4,7 135:22 149:21 minimizing [2] 201:21 242:
maximally [1] 203:22 16 185:17 292:22 330:7 150:14 151:14 164:20 166: 13
Maxwell [1] 199:15 meet [2] 75:2,6 18,20 191:4,5 322:18 340:5 mining [1] 225:11
Mayes [3] 294:18 296:4 320:9 MEETING [21] 1:5,9 2:1 5:4 6: 342:12 minor [1] 277:2
Mayo [1] 246:2 19 9:7 13:5 14:12 74:6,9,21 mg/ml [1] 170:3 minute [1] 340:8
Maze [9] 126:4,4,6 128:12 218:11 219:1 222:6,9 225:7 Miami [2] 8:8,9 minutes [14] 10:20 41:12 42:
198:8 232:7 258:10,12 357: 230:3 240:1 281:20 365:20, mice [9] 67:7 79:10 91:6,18 19 44:4 59:13 68:16 86:3 91:
15 21 101:4,10 133:19 153:20 362: 10 99:7 144:12 151:17 203:6
McCann [1] 200:15 meetings [1] 199:5 10 219:17 260:5
mcg/ml [9] 60:7 73:2,10 151: MEG [1] 360:18 Mickley [1] 62:15 mispronouncing [1] 42:4
4 170:9,12,16 205:22 206:7 Melbourne [1] 200:15 microarray [3] 298:11,13 miss [1] 115:12
McGowan [3] 306:1 345:8,10 Mellon [19] 2:32 3:14 5:18,18 314:2 missing [1] 37:19
McLeskey [5] 2:14 8:20,20 9: 14:4 19:1 41:4,9 69:1,6,16 microcephaly [1] 195:2 mistake [1] 221:7
18 10:2 70:10 71:4 72:9 73:4,17 74:1 micromolar [5] 154:8 156:4 MIT [1] 306:10
McLeskey's [1] 9:21 205:22 341:4 157:8 159:7 160:9 mitochondria [4] 78:14 129:
MDA [1] 294:15 member [4] 7:1 202:9 311:9 micromoles [1] 159:9 7,8,10
mean [11] 118:1 140:19 176:5 316:14 microPET [3] 180:16 270:10 mitochondria-dependent
198:10 204:3 212:6 215:19 MEMBERS [15] 2:5,13,16 11: 289:1 [1] 300:7
257:11 287:10 352:15 362:8 2 16:10 37:4 182:18 198:15 microphone [2] 219:14 345: mitochondrial [9] 79:16,17
meaningful [3] 111:16,17 200:6 203:9 220:1 243:19,19 10 98:11 129:1,5 158:11,22 159:
113:14 311:5 316:3 microscopic [1] 81:13 4 177:5
means [9] 36:19 51:21 80:4 membrane [7] 78:17 79:3,17 microscopically [1] 300:14 mitochondrion [1] 78:15
108:22 138:10 219:11,12 98:11 115:6,9 129:7 microscopy [2] 78:9 90:21 mixture [1] 288:16
242:7 258:18 membranes [1] 18:11 mid-gestation [4] 76:7 103:5 mixtures [2] 181:19 288:13
meant [2] 22:20 109:13 memory [17] 55:14 62:18 119: 163:4,6 MK-801 [5] 42:10 43:8 54:13
meantime [1] 202:21 3 145:7 256:20 257:1,6 258: mid-synaptogenesis [1] 210:18,19
measure [5] 121:7,13 274:9 9,22 259:2,9 267:7,13 276:13 103:5 MK-801's [1] 50:21
mock - neurodegeneration

mock [1] 55:10 14 244:11 258:13 287:13 4 232:6 233:5,7 234:16 243: 266:4,8 270:22 277:12,15
mode [1] 280:12 morning's [1] 13:15 14 244:11 249:4,5,5,6 251:19 287:6 289:16 307:13 308:11,
Model [45] 3:17 12:10 42:8,15 morphine [14] 143:2 213:1 253:7,13 255:22 256:6 260: 11,19 315:6,15 316:4 317:15
46:16,17 48:17 53:6,21 54:6 227:21 272:6,16 273:3,4,5 15,16 266:12 272:21 284:3 318:17 321:2 325:1,13,14
55:1 57:12 59:10 62:15 64: 323:1,4,6,9 347:6,22 285:11 290:6 294:6 302:2 327:22 329:1 330:15 342:5
16 65:1,21 67:9 92:12 107: morphological [5] 35:16 305:15 307:8,10 316:19 318: 344:5 348:6 359:2
11,21 108:1 150:2 161:8,9 145:17 268:2,5 270:2 14 329:8 332:20 336:15 339: needed [12] 25:16 26:13 36:
177:2 187:10,21 193:10 202: morphologically [3] 209:9, 14 343:18 346:7 352:19,21, 12 121:10 144:2 163:12,20
12 205:2 233:3,15 246:13 16 300:13 22 354:18 355:13 356:5 358: 213:1 313:7 327:13 343:21
269:11 274:16 276:2 277:16 morphology [1] 124:20 20 362:11 345:6
278:7 288:2 294:20 298:12, Morris [5] 126:3,6 232:7 258: Muir [2] 4:13 249:16 needing [1] 318:7
19 328:12 340:21 10,12 multi-center [1] 200:12 needless [1] 132:14
models [23] 12:5 52:8 55:18 mortality [5] 195:13 242:15 multi-national [1] 200:12 needs [12] 70:13 221:21 273:
65:14,22 72:6 189:18 193:9 245:9 247:5,21 multiple [13] 50:6 55:6,7 66: 14 300:19 314:12 324:5 326:
276:17 277:6,21 288:4,5,9,19 Morton [1] 200:16 19 67:6 150:13,19 246:3 291: 14 331:6 349:14 358:4,12
292:14 294:5 310:12 327:6 most [42] 23:20 27:4 28:11 30: 9 318:18 328:20 330:17 346: 363:4
342:11 346:12 356:13 357:8 16 32:18 36:10 40:8 56:5,10, 22 Neil [1] 200:16
moderation [1] 308:12 11 69:14 75:1 93:13 109:13 murmurs [1] 109:20 neither [4] 123:8 232:16 233:
Modernization [1] 31:12 115:13 130:16 131:22 140:9 muscle [4] 184:14 252:16 8 313:9
modes [1] 180:3 141:21 143:13 144:20 145: 253:10,21 neocortex [1] 87:8
modest [1] 233:18 21 150:4 190:14,19 209:15 musculoskeletal [1] 38:21 neonatal [21] 24:7 53:6 54:5
modification [1] 265:19 223:19 231:11 242:7 248:1 must [7] 24:20 25:1 31:7 48:9 55:9 59:9 61:11 193:14 196:
modulate [1] 246:21 276:9 278:10 286:19 294:16 85:21 237:14 239:10 6 198:17 199:15 244:12 273:
modulation [1] 246:17 302:18 305:1,6 325:21 334: mutant [1] 79:10 7 281:22 282:16 305:11 307:
molecule [2] 107:14,16 15 339:7 344:10 357:22 myocardial [1] 247:8 14 308:9 317:5 324:4 331:10
molecules [1] 263:3 mostly [2] 271:8 331:17 myself [1] 205:20 357:15
mom [3] 283:18 284:14 285:7 mother [12] 21:1,15 105:16 neonate [10] 21:5 183:22 185:
mom's [1] 283:20 134:9 135:8,9 192:20,21 257:
N 13 189:12 192:16 194:8 200:
moment [6] 24:14 58:6 83:8 12 279:6 283:22 351:3 N-methyl [1] 18:3
14 271:22 344:12 347:16
89:17 301:9 330:9 mothers [4] 19:22 269:14 naive [1] 237:10 neonate's [1] 194:15
moms [4] 284:9,18,21 285:1 284:1 356:7 name [3] 5:18 220:6 224:5 Neonates [22] 112:13 184:3,
money 201:10 264:2,14
[4] motivate 291:6[1] narcotic [2] 135:15 186:3 6,22 185:14 195:10,12,17,21
motivated [3] 250:15 277:12 narcotics 22:9
[1]
325:19 196:12,14 200:20 248:16
monitor [5] 108:18 168:11 356:7 narrow [2] 39:1 261:8
271:14 272:5 273:10 287:6
motivation [5] 211:9,18 212: nation 135:18
[1]
252:19 253:21 255:22 323:6 343:17 344:4 346:4
monitored [3] 119:5 190:3 13 251:5 290:17 National [16] 5:15 12:2 29:17, 349:18
223:9 motivator [1] 126:9 18 30:2,5 44:21 47:2,5,12 48: nerve [1] 279:21
monitoring [10] 108:21 167:8, motor 62:10 276:14 285:
[4] 2 65:16 147:16 225:1,17 322: nervous [12] 38:21 110:10,11
13 186:9 189:17,19 244:1 16 349:9 3 147:14 148:10 149:5 162:22
250:4 252:21 253:14 mounted [1] 186:4 natural [6] 43:21 77:15 117:
167:4 172:16 173:8 240:8,9
monitors 254:16
[1] mouse [22] 61:11,21 63:17 22 273:11 353:10 358:6 Neuberger [1] 345:22
Monk's [2] 247:17 248:6 64:16 77:11 80:10,20 81:17 naturally [2] 81:2 363:7 neuraxial [1] 34:20
86:1,13,17,18,19,21 88:3,15 nature 37:15 39:16 113:15
[7]
monkey [30] 48:19 49:8 65: neuro-opioid [1] 321:11
21,22 67:10 93:17,19 94:1 92:12,15,16,18 93:5 246:13 163:10 177:19,21 274:5 neuro-opioid-agonist [1]
99:9 102:7,15 104:19 156:22 move [9] 116:7 125:5,8 154:6 nausea 251:22
[1]
135:15
162:21 163:3,16 164:14 166: 157:8 180:10 204:15 207:5 NCTR [10] 12:6 47:1 147:16
neuroanatomical [1] 62:1
8,8 174:3,5,11 177:18 178:9 325:7 149:20 157:3 167:6 182:6,11 neuroapoptogenic [1] 97:
179:16 206:21 207:5,20 318: moved [5] 136:1 232:2,13 290:13 291:1 12
14,16 255:19 268:17 Neal [1] 248:7 Neuroapoptosis [46] 3:13
moving [4] 100:6 270:17 309: near 216:12 251:9 326:9
[3]
monkeys [12] 12:8,15 95:2 39:21 41:6,8 54:22 60:1,10,
99:17 156:15 163:12 207:13 3 333:4 nearly [3] 179:17 247:5 305:
17 61:18 62:17 64:2,6,11,12
214:3,11 290:19 291:4 318: MPH 2:3,18 3:5
[3] 15 69:3 75:14,17 77:3 79:8 85:
11 MRI [1] 196:1 necessarily [6] 37:6 52:19 13,17,22 86:8,13,15 87:2 88:
month [6] 112:12 189:9 271: MRIs [1] 275:6 136:19 230:5,8 351:5 7 89:5,9,14 90:2,7,12 91:13
22 314:21 355:5,5 MTT [1] 158:22 necessary [7] 21:22 58:15 92:11 94:17 97:4,20 98:21
monthly [1] 102:14 mu-receptor [1] 19:5 60:5 175:5 204:20 216:4,10 106:17,18 107:3 118:21 277:
months [18] 32:11 49:10 62: much [94] 36:10 41:3 52:15 necessity [1] 20:14
16 282:1 362:6
10 117:11 119:4 125:17 142: 54:6 57:20 68:14 73:22 81:6, necrosis 18:9 50:10,15
[9]
neuroapoptotic [3] 64:21,22
18 144:19 163:5 189:7 212:4 7 85:15 101:5 105:8 107:19 158:7 161:2 174:3,10,12 177: 91:16
232:15 246:12 262:6 296:19 109:6 119:14,18 123:7 124: 11 neurobehavioral [8] 65:6,8
305:11 317:6,7 13 125:10,11 128:5,10,14 necrotic [2] 18:13 177:18 77:6 103:10 274:20 275:14
morbidities [2] 185:6 201:21 130:10 131:9 133:1 134:11 necrotizing [1] 344:12 346:2 358:17
morbidity 195:13 242:14
[4] 137:3 138:20 140:13,20,21 need [53] 10:7 28:8 40:7 46: neurocognitive [5] 104:8,10
245:9 247:4 146:2 147:4 148:4 152:1 153: 15 73:20 111:12,13 117:17 105:6,11 197:22
morning [18] 5:9,14,17 6:13 5 159:13,19 174:7 179:5 182: 120:8 146:17 159:14 190:5,9, neurodegeneration [25] 11:
7:13,18 8:15 11:1 16:9 40:15 16 184:4 191:21 198:1 203:5 10 195:11 202:4 208:3 223: 7 12:15 47:14 48:14 49:17,
41:9 48:5 114:15 133:15 181: 208:12,19 213:12 226:5 230: 17 231:8 239:11 244:14 247: 19 50:3,13,18 53:19,21 54:2
15 249:3 250:21 253:4,13
neurodegeneration - occurring

55:12 61:21 62:2,8 63:17 65: 19 177:15 183:12 194:7 214: nominate [1] 47:2 293:2 338:10
20 78:10 122:7 188:17 245: 13 260:3,12,14 274:8 291:21 nomination [1] 47:11 nuclei [4] 123:3,19 132:12
16 265:3 278:16 324:19 335:12 non-anesthetized [1] 185:4 174:7
neurodegenerative [4] 16: neurotoxicologists [1] 44: non-cancer [1] 225:21 nucleolus [1] 78:22
19 189:1 230:11,19 20 non-caspase [1] 300:10 nucleoplasm [2] 79:6 115:
neurodevelopment [1] 343: Neurotoxicology [2] 147:15 non-caspase-dependent 10
18 314:21 [1] 339:2 nucleus [5] 78:12 81:16 82:8
neurodevelopmental [11] neurotoxins [2] 321:4 325:4 Non-Clinical [3] 3:24 183:2,4 96:15 115:3
75:9 106:19 186:17 192:6 neurotransmitters [4] 115: non-delayable [1] 307:19 nullify [1] 288:1
193:15 196:17 197:9,18 201: 22 116:4 117:21 297:3 non-human [7] 12:12 93:4 number [27] 43:18 55:1 74:22
2 204:2 346:4 neurotrophic [1] 299:10 163:21 176:13 181:17 203: 77:21 78:6 82:14 87:12 90:
neurogenesis [7] 269:15,16 never [7] 23:3 127:22 134:18 14,16 18 91:12 93:9 99:16 106:20
270:3,4 324:13,15,20 212:18 215:12 303:22 345: non-invasive [5] 165:19 180: 124:3 138:1 140:11 154:20
neurohistological [2] 104: 18 12,17 359:22 361:5 163:9 171:16 180:2 223:20
19 179:18 Nevertheless [2] 25:13 104: non-patient [1] 222:10 224:10 247:10 261:3 264:4
neuroimaging [3] 349:4 361: 18 non-rodent [1] 56:8 290:13 317:3 354:3
11 363:3 nevi [1] 144:2 non-selective [1] 280:1 numbers [6] 23:15 81:7 120:
neuroischemia [1] 260:8 New [18] 7:9 13:10 28:12,17 Non-SGE [1] 2:26 7 221:18 264:9 272:19
neurologic [1] 301:6 29:14 31:19 32:16,21 45:14 non-synaptic [1] 17:19 numerator [2] 38:3,6
neurological [5] 13:2 16:13 56:6 185:17 227:18 244:4 Non-Voting [3] 2:13,26 9:19 numerous [2] 195:18 289:16
334:18 343:3 344:8 249:3,9 290:15 300:12 352:1 Nonclinical [4] 33:11 57:16 nursery [3] 308:14 330:15,16
neuron [11] 92:22 93:14,15 newborn [2] 242:9 257:17 310:12 333:11 nutritional [4] 57:10 111:11
94:11 98:4 100:20,22 103:4, next [24] 9:1 16:3 28:15 41:4, none [3] 120:8,9 323:19 283:19 284:13
12 117:17 118:2 12 52:5 74:2 107:20 147:6, Nonetheless [3] 38:12 48:1 nutritionally [1] 285:10
neuron-induced [1] 259:21 12 182:22 224:18 229:7 231: 65:9
neuronal [25] 19:7,15 78:6 12 234:17 236:21 239:19 nonhuman [4] 46:16 47:4,15
O
80:16 81:6 82:10 87:10 103: 243:16 249:13 256:8 293:16 48:6 o'clock [2] 182:20
217:1
2 104:18,20 111:4 114:1,9 301:21 312:14 333:17 nonrandomized [1] 246:20 O.R [1] 239:16
116:2 140:11 146:3,7 177:17 NICDH [1] 198:17 nonsignificant [1] 64:1 obliged [1] 75:3
185:15,19 256:17 260:13 nice [8] 70:22 72:12 74:13 Noon [1] 217:2 observation [5] 141:19 143:
294:3 302:3 321:16 172:19 175:8 176:8 185:16 nor [1] 313:9 12 214:20 215:18 306:5
neurons [55] 17:9,21 43:13, 214:20 norketamine [1] 170:19 observations [2] 43:19 44:
14,17 50:15 51:10,10,13 64: nicely [3] 148:3,4 162:12 normal [11] 18:20 51:5 81:17 13
22 73:14 74:19 75:1,6,7 77: NICHD [1] 182:11 114:5 162:3 173:10 198:2,10 observe [1] 130:18
14 80:11 82:5,11 87:12 90: NICHED [1] 8:14 320:8 346:8 358:2 observed [7] 18:4,18 20:3,4
19 92:16,20 95:13,21 96:5,8, nickel [1] 291:2 normalize [1] 264:9 58:18 75:16 130:11
11 98:19 102:19 103:6,8 104: nicotinic [2] 210:7,13 normally [9] 18:16 51:11,13 observers [1] 198:14
9 111:6,12,17 113:11 114:7 NICU [1] 272:13 75:1,8,9 133:10 149:4 161: observing [2] 121:2 203:22
115:1,17 116:6,11 123:21 nightmare [2] 254:4,9 13 Obstetric [2] 7:11 350:5
138:1 139:15 140:11,12,15 NIGMS [1] 256:12 north [1] 249:19 obstetricians [1] 108:11
242:5 257:19 269:2,7,19 277: NIH [4] 44:14 256:12 325:17, Norwood [1] 332:10 obstruction [2] 21:8 273:18
18 282:5 19 notable [1] 30:16 obtain [5] 47:3 57:19 70:5 72:
neuropathogenesis [3] 235: NIH-funded [1] 346:3 notably [3] 28:11 79:3 99:10 13 170:16
2,14,17 Ninety-eight [1] 240:20 note [9] 5:12 6:19 9:17 19:17 obtained [11] 46:15 49:20 58:
neuroprotectant [2] 194:3,6 ninth [1] 355:5 32:18 48:18,22 65:7 247:22 2 60:2,11,19 73:3,4 95:1 120:
neuroprotection [3] 260:7 nitrous [27] 19:11 54:14,21 noted [20] 10:9 18:7 24:8 27: 17 257:16
291:16 335:8 83:15 117:8,13 118:15,15 4 33:22 39:14 42:16 44:2 46: obtaining [1] 120:14
neuroprotective [10] 194:2, 136:1 137:17 143:7,8,9 184: 6 49:17 53:17 61:16,19,20 obvious [7] 71:14 105:8 115:
12 259:15,18,22 260:1,6,11 14 210:5 251:14 295:7,12,16, 64:4 65:6 71:12,14 197:1 11 230:21 307:7 334:20 342:
294:19 335:21 18,20 296:1 297:1,10 304:11 318:5 10
neuropsych [1] 264:18 319:1 328:21 nothing [7] 119:2 135:7 183: obviously [12] 48:20 57:9
Neuropsychological [1] NMDA [53] 18:3,19 19:4,12 18 201:14 221:15 232:22 105:19 116:5 205:11 216:7
348:20 39:10 42:11 43:8 46:1 48:11 286:20 251:4,19 285:2 338:6 351:19
Neuroscience [2] 306:12 50:22 51:18 66:20 71:9 75: notice [6] 23:14 74:14 121:15 361:8
314:4 18 76:17,20 82:17 84:2 106: 219:10 250:22 285:2 occasional [5] 87:9 123:19
neuroscientists [1] 187:18 8,15 116:18 117:6,9,13 148:8, noticed [2] 143:10 230:17 171:7 172:8 173:9
Neurosurgical [1] 7:17 15,18 154:13,16 155:2,18 noting [2] 20:2 23:1 occasionally [1] 303:10
neurotoxic [7] 48:11 78:19 161:3,14,21 162:5 174:19 notion [2] 260:21 271:15 occasions [1] 149:22
259:17,18 260:4 297:13 335: 175:2 176:18 178:1 181:21 novel [2] 142:14,15 occupational [1] 125:2
21 186:19 209:1,18 210:5,12,19 nowadays [2] 143:9 210:11 occupationally [1] 301:1
neurotoxic-protective [1] 283:4 295:3 297:4,15 318:22 NR1 [10] 148:19 154:15 155:2, occur [17] 18:15 49:12 50:6
259:15 321:13 322:11 12,16 160:11 161:4 174:19 75:10 77:16 98:6 101:15,16
neurotoxicities [2] 274:3 NMDA-antagonist [1] 296:9 178:1,4 114:5 176:20,21 179:5 201:6
327:20 NMDA-receptor [2] 11:8,14 NSQIP [1] 247:9 202:14 279:13 293:8 306:7
Neurotoxicity [23] 3:15,18, no-effect [1] 278:18 NST [1] 281:20 occurred [4] 32:20 39:16 122:
22 11:12 12:9 14:2 46:2 63: no-go [1] 36:10 NTP [2] 47:21 182:10 3 362:14
10 74:4,7 107:22 108:2 147: nodding [1] 365:2 nuclear [6] 79:3 115:4,6,9 occurring [20] 43:17 46:21
50:20 51:1 58:13 59:19 90:8
occurring - OxyCotin

105:2 122:15 132:4 153:15 10 226:2 229:1,1 232:16 234: options [3] 15:20 223:15 249: 8 289:16,17 300:1 314:4,9,20
170:20 177:11 189:13 202:2 7 235:3 237:21,21 255:1 261: 9 322:5 327:21 333:20 338:16
245:18 274:10 317:21 343:9 3,5 262:21 263:2,5 266:1 oral [1] 218:16 352:14 353:11 357:11 358:
360:3 268:16,22 271:1 274:5 276: orbitofrontal [1] 348:22 18 363:5
occurs [12] 17:4 49:9 76:3 80: 15 278:12 282:10 284:11 ordeal [1] 37:10 outcome [21] 56:21 107:16
1 113:2 122:7 192:1,8 199: 289:15,19 292:18 296:3 299: Order [16] 3:2 5:2,3,5 21:1 58: 196:11,18 197:9 199:21 205:
22 202:17 241:8 278:7 5 302:16 304:20 306:1,11 15 74:12,13 85:5 119:20 175: 8 245:13 246:14 247:3 248:3,
odds [1] 234:13 307:20,20 309:17,21 310:9 6 238:17 266:2 271:2 300:3 10 279:9 343:14,19 346:4,11
off-patent [1] 32:7 311:13 313:22 314:15 316:9, 359:3 348:12 349:18 352:12 358:7
offer [5] 229:3 243:1 335:1,8 14,14 321:7 323:2,4,18 324:7, Oregon [3] 8:17,18 228:5 outcomes [11] 36:5 106:13
365:3 12 327:1,12 331:3,13 335:5, organ [4] 38:19 39:2 110:8 199:20 245:6 248:22 275:9
offered [2] 59:5 229:1 13,18,22 338:1,7 339:7,8 342: 194:18 276:10,20 282:17 357:2 359:
offering [1] 112:8 5 349:21 350:6 355:12 358: organic [2] 250:10,21 4
offers [1] 288:11 16,18 359:3,12,20 364:7 organized [1] 146:18 outlasting [1] 231:3
Office [5] 5:13 38:12 45:1 46: one-third [1] 88:19 organohippocampus [1] outline [1] 41:18
5 58:3 one-time [2] 85:11 86:11 287:21 outlined [1] 81:16
Officer [4] 6:1 28:22 227:17 ones [9] 168:15 172:20 226: organophosphate-induce outside [4] 137:3 161:14,22
243:22 20 281:6 291:10 317:7 320: d [1] 107:10 357:9
Official [1] 6:18 15,20 344:15 organophosphates [1] 300: outweigh [1] 33:19
often [9] 16:22 33:5 84:10 ongoing [2] 165:17 317:18 22 outweighs [1] 27:1
135:16 222:21 234:12 268:4 only [54] 11:13 15:17 25:15 organs [2] 190:13 241:5 over [49] 11:10 18:20 22:21
352:1 354:18 31:8 52:16 54:8 75:2 82:4 85: orientation [2] 74:19 75:11 28:1 32:20 37:17 38:22 41:
oftentimes [1] 352:18 16 94:16 97:9,14 106:9 108: original [1] 59:7 11 42:19 43:2,2 44:3 49:20
Okay [8] 100:16 219:20 310:6 9 120:13 125:18 133:16,19, other [121] 10:5 11:14 12:7 19: 52:12 57:9 68:11 76:21 81:
311:2,4 315:22 329:17 341:2 21 135:7 137:16 143:9 150: 20 22:3 27:2 35:20 39:10 50: 10 83:16 93:1 108:4 121:20
old [16] 101:21 261:11,18 262: 15 154:7 158:6 176:4 177:9 7,21 54:12 57:6 58:7 67:1 68: 128:10 132:8 135:4,20 138:
9 263:7,9,12,13,15 264:3 276: 179:10,20 180:12,18 187:3 21 69:2 76:10,10 78:2 79:11 14 148:1 149:22 150:15,19
19 277:1 298:12 314:16 317: 211:3 212:4,15 213:13 220: 83:4 101:1,14,17,18 103:6 167:10 182:7 184:1 186:7
7 320:15 13 224:10 231:7 232:20 235: 106:12 116:7 125:20 138:21 188:21 225:13 228:8,13 254:
older [10] 27:14 30:21,22 143: 5 236:7 239:10 261:19 264: 141:9 148:20 153:22 165:12 17 262:14 264:7,7 270:4 285:
16 176:1 179:15 265:15 307: 16 266:6 279:13 284:15 304: 181:9,18 187:22 200:18 202: 5 290:22 303:13,13 360:21
21 324:13 327:18 21 305:17,22 311:4,8 316:14 5 215:7,10 218:22 220:22 overall [3] 233:20 284:1 339:
oldest [1] 251:1 onset [1] 276:18 222:1,7,12 223:15 224:6,7,11 7
oligomer [2] 231:14,15 Opana [1] 226:19 227:9,20 229:12 235:21 242: overcome [1] 254:14
Olney [50] 2:27 3:16 11:5,10 OPEN [18] 4:2 14:11 168:15 5,8 245:5,15 255:9 262:1 overdose [3] 206:12 222:19
13:9 14:9 42:5 48:14,16 51:6 203:7,9 217:1 218:2,3,6,10, 267:11,12 268:22 270:12 228:18
54:6 63:15 71:5 74:3,5,8 99: 15 219:9 243:13 266:15,18 271:7 272:3 274:4 275:9 276: overlap [1] 205:13
6,13 100:15,18 101:3 102:12 274:22 289:8 325:20 3,17 278:12 279:14 287:17 overly [3] 109:7 210:1 296:8
103:14 104:5 106:14 107:18 operant [1] 291:3 288:1 289:9,13 290:2 292:11 overproduces [1] 232:4
124:15 128:17 129:6 133:14 operate [1] 291:3 297:2,5 299:3,21 308:8,12 oversedation [1] 109:19
149:8 187:3 202:11 203:12, operating [11] 133:12 136:5 309:5,6,19,20 311:14 313:3 oversight [1] 225:5
16 209:4 256:18 277:11,14 137:13 187:11 188:11 189: 314:13 316:20 324:1,7,8 327: oversimplification [1] 229:
278:1,6 279:2 280:8,17 281: 10 249:21 253:18 301:21 5,12,15,19 328:15 331:7,13 12
2,12 298:21 304:14 361:4,9 330:17 334:2 335:10,13 336:13 338:16 overstate [1] 225:15
Olney's [14] 46:8,14 49:3 59: operation [2] 142:18 351:14 339:16,19 341:1 343:2 344: overstimulation [1] 193:20
4 63:11 114:18 117:7 118:4 operations [1] 100:21 16 349:4 350:1 357:9 358:19 overturned [1] 31:22
186:14 194:18,20 267:17 operative [1] 272:10 361:7,16,18 362:3,11 365:7 Overview [7] 3:9,20 14:5 16:
269:1 295:17 opiate [1] 322:10 others [14] 11:10 64:9 115:17, 3,7 147:17 175:10
omitted [1] 6:21 opiates [2] 252:15 331:17 21 149:19 256:15 262:22 overwhelming [1] 364:14
on-board [2] 253:13 356:1 opinion [4] 96:21 97:5 229: 284:1 291:1 317:14 331:3 own [13] 59:2 149:13 196:22
once [11] 57:18 59:13 98:8 15 324:17 342:1 353:1 357:14 202:2 206:3 221:1 239:22
111:7 226:12 270:4 307:8 opioid [9] 220:3 225:1,8 226: otherwise [5] 145:11 146:11 250:4 273:12 298:13 301:11
336:20 338:15 357:14 362: 14,16,17,18 228:14 323:2 336:21 342:8 347:18 307:3 361:11
13 opioid-addicted [1] 226:1 ought [2] 322:12 354:10 Oxford [1] 184:20
ondansetron [1] 251:15 opioids [22] 19:6 21:16 35:6 ourselves [1] 361:10 oxidative [2] 181:7 293:19
one [129] 6:14 10:1 14:4 24: 36:1 67:2 222:1,7,12 225:6, out [72] 25:14 31:16 49:6,9,17 oxide [21] 19:11 54:14,21 83:
16 25:17 39:9 44:6 45:20 54: 18,20 226:4 227:7 228:8,9,10, 77:20 79:19 81:22 85:19 100: 15 117:8,14 118:15,15 136:1
20 55:4,8,17 56:7,8,13 57:1 11,13 321:1,3 322:22 328:22 5 107:17 125:8 126:9 127:5, 184:14 210:5 251:14 295:7,
58:7 68:17 71:20 83:7 84:6 opportunity [6] 220:1 224:21 10 129:10 132:14 145:2 150: 12,16,20 296:2 297:1 304:12
85:16 88:12 90:4 91:3 97:21 234:18 243:11 275:17 288: 3,12 151:21 152:8 153:4,7 319:1 328:21
98:8,15 99:8 103:1 109:22 11 157:3 159:13 161:3 162:16 OxyContin [21] 220:22 221:3,
121:3 143:9 146:14 148:15, opposed [4] 209:19 227:8 164:2 168:1,3 171:3 190:2 4 222:1,7,11,15,17,20 223:4,
17 151:7 153:14 155:21 158: 270:3 342:17 191:1 193:7 195:4,10 197:22 7,16 224:11 225:14,16 226:3,
3 162:7 163:20 168:3 170:20 optical [1] 138:1 198:4,16 200:6 203:2 208:8 21 227:5,18,20 229:1
173:21 176:10 177:8 180:3 optimal [1] 268:14 224:9 252:9 253:15 261:14 OxyContin-related [1] 224:
181:9 182:1,2 189:21 206:15 optimizing [1] 242:14 264:15 265:5,8 269:1 270:13 14
207:15 209:22 214:8 220:10, option [1] 36:9 271:10 272:9,18 273:11 282: OxyCotin [1] 227:13
oxygen - Perspective

oxygen [8] 90:6 100:12 137:7, participant [1] 10:6 18 303:11 309:1 310:18 330: 5 269:2,7,20 295:19 307:16
7,10 167:18 168:9 252:15 PARTICIPANTS [4] 2:28 9: 16 331:5 340:16 343:4 344:2, 346:10 352:4
13 10:7,10 10,11 345:6 353:19 357:22 percentage [2] 75:3 360:9
P participate [2] 9:18 360:4 360:4 Percocet [2] 226:9,10
p-1 [1] 133:3 participation [1] 239:22 Patrick [1] 228:19 perfect [4] 102:13 121:11
P-119 [1] 259:1 particular [63] 9:10 10:1 13: pattern [8] 78:1,5 80:17 81:4 134:19 286:1
P-120 [1] 258:17 19 19:10 42:7,13,15,22 43:4, 95:11 102:17 124:13 274:6 perform [1] 199:10
p-3 [1] 133:3 6,16 44:1,2,8,12,16 45:5,7,16 patterns [2] 62:1 96:5 performance [3] 62:11 127:
P-36 [2] 258:16,22 46:19 48:22 51:18 53:16,21 paucity [1] 24:9 17 263:22
P-5 [1] 314:10 54:9 55:2 58:8,20 59:5,16 60: Paule [1] 291:1 performed [15] 14:6 21:22
P-6 [1] 314:10 3,11 61:9,17 64:8,20,22 65: payment [1] 218:21 22:2 33:5 36:11 84:21 93:18
P-7 [5] 314:1,5,8,10,16 15 66:18 67:12 68:11 70:15, PCO2 [1] 137:6 119:22 120:13 121:17 127:
P-75 [1] 300:2 16 84:6 93:20 108:7 110:2 PCP [1] 83:14 16 141:13 199:20 200:20
P-8 [1] 314:10 113:6 119:12 129:13 151:4 peak [22] 65:2 112:10,22 113: 285:20
P-9 [1] 314:10 152:7 154:12 165:5 166:21 4 118:19,22 119:10 123:4,5 perfusion [1] 190:6
p.1 [1] 123:8 250:19 292:13 293:13 299: 131:22 145:20 150:3 162:18 perhaps [41] 51:8 55:2 60:22
p.14 [1] 123:8 11 322:9 324:2,14,16 191:14,19,19,22 192:5,7,17 61:4 62:2 64:8 67:14 107:7
p.m [2] 217:3 365:21 particularly [17] 17:10 46:20 203:19 269:8 150:21 158:6,7 162:15 180:
PACU [2] 250:11 251:13 58:20 112:13 201:20 283:4 peaked [1] 65:1 13,14,19 184:15 186:20 187:
Pain [28] 6:4 21:13 35:16 137: 285:6 288:10 292:16 308:9 peaks [3] 193:4,5,5 9 189:11 191:8 193:4 194:6,
2 184:3 185:12,15,20 193:13 310:14 317:21 322:12 324: Pediatric [70] 3:10 7:6,14,19 11 195:4 197:5 202:13 204:6,
199:15 201:17 220:18 223:5, 10 337:10 348:14 363:6 8:6 11:16 12:22 13:17,18 15: 18 212:17 216:12 255:8 261:
10 225:12,15,21 227:16,16 parties [2] 9:10 226:10 4,15 16:5,8,15 21:20 23:13, 5 272:4 289:20 290:4 292:2
228:1 304:7 308:22 316:5 parts [2] 101:17 195:19 19 24:4,9 27:12 31:7,10,17 293:1 320:17 337:19 338:12
317:8,19,21 328:5 331:2 party [1] 229:1 32:9,14,16,19,21 33:5,8,12, 344:16
painful [3] 68:19 193:8 303: passed [2] 28:10 29:3 14,16 34:2,4,22 35:8 38:16 Perinatal [3] 65:21 191:22
15 passing [1] 279:15 40:6 71:21 73:3 97:13 108:6, 230:5
pair [1] 316:15 past [4] 28:1 32:20 75:5 320: 7,10 135:16 183:11,14 189: perinatally [1] 276:18
pairs [1] 316:13 21 13 198:13,19 200:10,18 202: Perinatology [1] 7:12
Palladone [3] 223:1 226:19, patent [2] 185:1 196:15 9 244:7 248:16 249:1,22 255: period [56] 12:10 16:21 17:2,
22 patented [1] 32:7 15 291:14 306:18,20 307:17 9 18:5 22:11 31:14,14 42:20
panel [15] 43:6,7,12,19 123: path [2] 127:7 339:20 308:15 322:19 330:13 331:5 49:1,8,11,16 66:4,4 75:22 76:
18 124:1,1 125:15 128:18 pathogenic [1] 263:2 334:13 343:4 364:9 1,2,3 84:5 90:7 93:5,20,22
183:7 191:2 198:15 200:5 pathologic [1] 339:20 pediatrician [1] 8:11 102:22 103:6,7 104:1 150:1,
203:9 207:8 pathological [1] 51:16 Pediatrics [7] 8:7 15:13 73:5 15,20 162:17 171:12 172:22
panelists [1] 187:22 pathologist [1] 123:17 110:2 213:14 326:17 328:6 192:5,7,17 193:14 201:5 202:
panels [1] 199:5 pathologists [1] 113:18 peer [1] 250:14 7 204:4 230:5 231:3 269:9
paper [26] 19:1 42:1,2,7 43:1 pathology [2] 80:17 114:21 peer-reviewed [1] 240:7 272:11 280:5 305:11 307:14
44:2,16 45:7 53:3,4,7,17 54: pathway [18] 79:12,16 106:19 pellets [1] 291:4 324:4 331:10 332:12 340:10,
4 55:16 59:5 65:5,19 70:19 107:13 129:5,13 131:12 276: pending [1] 28:9 17 341:9 359:7 360:22
90:3 114:20 144:22 145:5 8 298:16,22 299:4 300:7,8 penetrates [1] 350:12 periodically [2] 83:16 232:13
147:2 191:18 306:11 323:5 338:11 339:11 348:22 349: Pennsylvania [2] 4:8,17 periods [15] 52:3 63:8 85:5
papers [9] 44:6 45:8 52:10 10,12 pentobarbital [2] 143:1 319: 93:21 157:20 169:13 179:8
54:20 198:22 243:3 252:2 pathways [11] 18:2 107:7 14 192:11 308:10 313:6 346:19
262:19 269:6 128:18,22 294:8 300:9,11,13 pentothal [1] 28:4 353:2,13,14 357:18
paradigm [6] 121:11 125:21 348:22 349:1,2 people [35] 30:21 37:2 40:20 perioperative [1] 202:7
139:21 187:21 189:8 324:16 patience [1] 306:9 111:1 113:17 126:20 147:9 perioperatively [2] 21:3 22:
paradigms [3] 125:22 283:14 patient [20] 13:4 20:9 35:4 37: 182:5 212:7 216:8 221:17 19
324:1 7,20 40:6 188:10,10 190:2 224:2,3,7,15 226:8 236:20 peripheral [2] 223:5 279:21
parallel [1] 168:16 197:2 212:18 245:12 247:22 250:17 252:4 254:14,16 255: permanent [3] 82:11 257:1
parallels [1] 346:11 249:10 252:10 253:17 255: 10 270:21 288:12 308:16,18 274:19
paralysis [1] 184:16 17 265:18 286:15 351:12 309:5,7,12 319:5 329:22 350: permeability [1] 79:18
paralyze [1] 134:17 patient's [2] 190:10 196:7 13 359:15 361:11 363:17 permit [1] 243:13
parameters [3] 137:2 160:15 Patients [87] 3:10 12:22 16:5, peptides [1] 234:3 persistent [2] 55:13 265:4
169:15 8,15 21:20 23:19,22 24:9,12 per [9] 141:3 159:10 166:20 person [2] 224:1,3
paravertebral [1] 246:21 30:22 31:10 32:19 33:9 34:1, 215:9 222:16 249:20 261:21 personal [4] 221:13,16 336:1
parent [2] 4:3 306:3 2,22 35:8 37:4,4 38:17 40:8 317:16 338:9 342:2
parenteral [1] 23:5 142:17 184:13,21 187:12,15 perceive [4] 184:3 185:15,19 personality [3] 142:12 143:
parents [7] 15:16 142:4,7 189:21 195:14 197:14 201:4, 319:22 10,15
305:8 306:5,14 308:5 19 202:6,17,20 203:1 208:4, percent [52] 82:9 84:11,12 88: personalized [1] 292:22
parietal [2] 132:6 139:7 12 223:17 225:20,21 226:1 14,17,17,19 89:3,7,12 90:9 personally [3] 265:13 336:1
part [19] 9:6 27:15 40:8 44:12 228:1 230:9 234:9 235:18 91:9,11 92:3,3,4,7 107:15 348:15
50:6 51:5 54:9 59:16 135:16 242:15 244:7,10,16 245:5,20 114:8 130:1 136:2,2 140:13 persons [1] 28:7
162:11 188:13 235:13 297: 246:9 247:9,10,11 248:5,17, 142:1 143:14 164:13 166:10 Perspective [13] 3:24 13:13
15 306:13 320:1 322:2 326: 17 250:11 251:8 252:6,16,18 169:2,8 175:18 179:10 198:3, 41:19 56:1 57:16 61:4 68:4
12 333:22 362:8 253:15 254:21 255:15 262:2 9 232:11 236:6,15,16 240:20 71:8 86:4 89:18 183:11,14
partial [1] 97:10 264:7,9 266:11 271:20 272: 257:13,15,21 259:4,8,10 262: 342:2
partially [2] 77:5 318:15
perspectives - precise

perspectives [4] 46:21 68: physiological [19] 51:4 58: 177:7 192:10 194:1 195:10, post-natal [30] 53:6 59:10 66:
13 183:1,3 13 77:15 87:10,14 114:2,4,11, 20 197:10 198:4,16 200:7 2,5 111:22 112:13,17 150:2
pertaining [4] 79:13,14 93:7, 22 136:17 137:3 165:6 167:8 208:3 213:7,20 215:11 224:9 157:1 166:10 169:7,9 170:10,
18 169:15 189:16,19 207:17 229:15 234:7 261:14 264:15 13 171:18 172:7,9 175:22
perturbations [1] 242:10 269:3 270:5 265:17,20 271:7,10 273:21 176:2 178:10,12 179:16 214:
PET [2] 270:13,19 physiologically [2] 122:15 276:1,2 278:20 283:16 284: 12 257:6 258:4,10,20 259:9,
Pete [1] 228:16 164:2 16 293:22 300:19 302:17 13 292:14
Peter [6] 4:3 219:18,21 220:6 physiology [1] 206:16 304:18 308:4 312:14 314:1, post-natal-day [1] 314:1
225:4 249:1 pick [2] 298:16 337:18 14 316:6 319:5 322:21 334:9, post-natal-day-5 [1] 259:7
Peterson [1] 275:3 picked [2] 276:10 323:8 9,10 336:6,15 338:1 339:1,12 postconceptual [1] 108:19
Petition [2] 222:16 223:3 picture [8] 81:17 82:8 123:13, 340:1,12 341:14 360:10 postmarketing [1] 33:6
pH [1] 137:6 22 124:14 137:21 220:12 pointed [10] 150:3 162:16 postnatal [3] 186:18 192:2,9
Ph.D [13] 2:6,17,19,23,24,31, 297:9 191:1 193:7 195:3 208:8,15 postnatally [1] 150:5
32,33 3:11,14,19,23 4:16 pictures [1] 224:13 265:5 269:1 322:5 postoperative [4] 185:6 197:
phagocytic [1] 82:1 pig [5] 67:8 136:1,19 140:5 points [12] 14:14 104:15 164: 18 247:14 330:4
phagocytosis [1] 115:16 315:5 6,8,12 190:8 191:19 257:22 postoperatively [1] 35:22
pharm-tox [1] 45:13 pigs [14] 101:11 112:7,18 113: 310:8 317:14 319:3 338:18 postpone [1] 307:20
pharma [1] 8:21 1,8 134:4,6,21 136:3,8,18 poisoning [1] 192:21 postulated [5] 75:5 77:4 92:
Pharmaceutical [5] 10:3 45: 214:3 321:16,20 poisonous [2] 28:6,14 21 162:20 163:2
1 46:5 58:4 99:2 Pike [1] 1:10 poisons [1] 283:8 posturing [1] 252:5
Pharmaceuticals [1] 32:5 pill [1] 28:18 policy [2] 222:10 223:19 potency [4] 125:12 226:4 227:
pharmacodynamic [1] 58:9 pilot [2] 257:9 272:22 poll [1] 320:5 6 231:5
pharmacokinetic [2] 57:19 place [12] 43:21 45:7,21 127: Pollock [7] 2:22 8:2,2 286:7, potent [3] 42:11 226:14 231:
215:8 2 128:10 212:3 223:7 255:16 8 312:1 313:13 12
pharmacologic [1] 350:11 258:15 330:8 341:20 353:9 polymorphism [1] 294:10 Potential [36] 3:21 11:11 14:
pharmacological [2] 71:7 placebo [2] 272:16 273:2 polymorphisms [3] 293:3, 1 26:1,11,13 31:5 41:20 46:1
331:20 placed [1] 168:10 11 360:15 47:13 49:21 51:21 52:2 57:
pharmacologically [1] 280: placement [1] 21:9 poorly [2] 343:18 346:9 21 63:15 77:5 97:12 147:18
4 plain [1] 98:12 popping [1] 210:9 202:14 222:11,19 240:2 242:
pharmacologist [2] 7:20 8: plan [7] 199:17 200:19,21 201: popular [2] 253:8 292:13 8 244:12,14 246:17 261:10
11 1 206:20 293:15 320:13 populated [1] 82:5 275:17,18 283:8 288:11 293:
pharmacologists [1] 14:5 plane [9] 82:7 95:4 165:4 166: population [29] 13:4 20:9 24: 20 317:16 327:14 343:3 350:
Pharmacology [1] 45:10 13 170:14 207:12,14,18 216: 2 33:4,16 39:21 40:6 71:21 1
Pharmacology/Toxicolog 16 72:1 73:3 114:9 230:7 260: potentially [6] 58:10 67:22
y [1] 5:19 planning [1] 158:9 12 261:15 265:19 331:7,9,12 96:22 306:7 347:10 362:20
Phase [5] 33:6 165:20,21 166: plans [1] 274:2 332:6 349:17 350:5 351:13, potentiate [4] 116:20 117:4
4,4 plaque [1] 233:22 13 352:7 353:6,6 354:9 355: 238:9,19
phenobarbital [1] 194:22 plasma [23] 18:11 59:17 60:2, 18 356:6 potentiates [1] 71:9
phenomena [16] 43:14 44:1 11 73:7 100:4 151:2,10,19 populations [11] 24:5 27:5 potentiation [1] 119:2
45:5 46:19 50:18 56:9 58:18 152:2,16 153:1 167:20 169: 33:3 38:9 248:15 277:18 343: power [4] 219:13 246:8 345:5,
65:8 68:6 84:5 85:3 149:15 20 206:19 207:10,19 214:12, 7 347:4,13 362:22 363:16 7
151:8 158:20 179:1 278:4 14,21 215:6 216:19 340:2 portion [3] 14:12 284:6 333:5 powerful [1] 290:6
phenomenon [34] 44:9 51:5 plastic [1] 81:12 portions [1] 278:11 practical [4] 83:10 242:13
52:9 53:2,13 55:3 66:20 67:7 plasticity [1] 200:4 pose [2] 97:1 346:17 325:13 326:1
69:10 75:20 76:11,15 77:16 plateaued [1] 216:13 posed [2] 223:18 364:11 practice [25] 15:4 117:20 183:
78:8 79:14 82:17 83:1,5,7,22 platform [13] 126:10,11,13,14, position [5] 232:12 251:6 9 184:11 186:15 188:7 213:
85:5,10 112:19 114:4,12 115: 15,16,18 127:1,7,14 128:4,6 253:9 325:3 338:16 14 243:2 244:3 249:16,22
12,14 122:15 130:10 134:8 232:12 positive [5] 25:4 26:8,19 95: 253:7 301:11 305:20 306:1,
209:14 212:10 216:7 266:11 play [3] 191:12 221:14 291:7 17 279:16 14 307:3,17 308:1 313:11
phenotype [23] 71:12 103:16 playing [1] 293:19 positivity [4] 96:6,9,11,13 320:1,8 334:15 335:5 364:8
104:4 195:1,4,6 233:7 278: plays [1] 148:9 possess [1] 83:11 practiced [1] 225:10
14,16 287:11 302:16 303:5 please [5] 10:17 224:6 254:6 possibilities [1] 181:18 practices [2] 189:14 328:3
304:19 306:8 343:6 345:15 310:9 315:10 possibility [11] 13:2 25:11,14 practicing [3] 310:15 316:3
346:15 347:7,11 348:2 359:5 pleasure [1] 148:2 142:12 181:16 290:3 292:15 320:6
363:20,21 plop [1] 143:3 323:20 361:16 363:3,5 practitioners [3] 201:16 202:
phenotypic [1] 356:14 plus [4] 61:13 64:11 231:20 possible [18] 20:11,14 27:2 16 309:21
phenytoin [1] 194:21 242:19 51:6 57:4 97:5 98:14 106:13 pragmatic [1] 44:1
Philadelphia [1] 7:21 pneumonia [2] 247:14 347: 145:7 164:4 171:1 225:2 253: pre-birth [1] 196:2
phobias [1] 316:21 17 6 255:21 296:11 303:3 304: pre-existing [1] 195:22
phosphorylated [3] 299:16, podium [1] 219:10 17 361:8 pre-human [1] 282:12
22 300:4 point [84] 49:17 51:9 66:13 Possibly [3] 72:13 130:8 257: pre-op [2] 208:13,14
phrased [1] 311:3 67:3 68:9 69:15 70:11,12,19 6 pre-term [5] 272:12 273:15
phrasing [1] 332:16 72:9 73:18,20 98:6 100:4,5 post [3] 36:18,20 54:16 275:4 317:2,4
physical [1] 125:2 113:20 115:5 118:7 130:11, post-anesthesia [3] 144:19 preach [1] 221:16
physician [1] 228:22 19,19 140:4 142:6 148:15 286:5 296:20 precedent [1] 300:21
physicians [3] 97:2 188:12 149:11 150:12 155:15 163:1 post-birth [1] 296:19 preceding [1] 340:10
322:16 165:11 166:5,19 168:3 171:3 post-Day [1] 257:16 precise [4] 189:16,18 211:8
precise - protocols

241:9 12 22:13 40:22 71:1,18 74:2 probably [24] 99:18 113:7 professional [1] 142:4
precisely [1] 104:7 218:13 243:15,16 271:9 125:5 145:4 163:3 174:11 professionals [1] 249:8
Preclinical [45] 3:12,15,17 PRESENTATIONS [11] 3:6 177:18 189:6 201:7 206:22 Professor [6] 6:8 7:2 8:1,16
13:14 14:6,17,21 15:5 33:7 10:21 13:15 14:7,9 17:16 215:20 233:22 252:2 280:22 306:10 316:10
40:14 41:5,7 56:1 68:2,18 72: 148:2 203:7 267:1 324:7 365: 286:9 320:2,9 324:18 337:7 profiles [6] 81:20 87:10 95:
5 74:4,7 107:21 108:1 244:8 14 338:8,9 340:19 353:15 360: 17 96:13,16 319:1
245:16 246:11 248:11,20 presented [18] 41:15 42:9 67: 17 profound [3] 125:7 184:8
288:9 291:14,19 298:1 304: 19 72:8,20,22 103:20 184:7 probe [2] 121:7,12 267:18
15 308:5 318:3 319:6,15 327: 205:18,18,22 209:2 213:21 probes [2] 128:3 171:4 Program [5] 47:3,5,6,12 219:
6,13 328:9,11 331:14 334:4, 267:9 275:1 277:15 287:13 problem [26] 36:16 45:16 97: 16
15 342:11 346:12 350:21 340:3 2 104:5 145:7 192:18 193:22 programmed [3] 18:8 74:20
353:8 presenter [4] 41:4 219:17,18 200:11 220:2 221:11,15 222: 114:1
preclude [2] 9:6 219:8 260:17 6 225:2,4,17 226:3,21 227:1 programs [1] 198:20
precludes [2] 309:17 311:12 presenters [1] 10:17 229:5 265:10 284:15 319:7 progress [4] 48:5 145:15 270:
precocial [1] 101:11 Presenting [4] 2:26 48:4 71: 330:8 354:10,10 363:17 20 361:14
precondition [1] 259:21 6 74:11 problematic [2] 64:9 67:16 progressed [1] 216:4
predecessors [1] 191:2 presents [1] 197:3 problems [15] 109:19 127:22 progression [1] 233:2
predict [2] 72:15 293:5 preserve [1] 21:22 187:20 193:15 196:22 198:5 project [3] 248:9 256:11 348:
predicting [1] 69:13 President [1] 7:10 208:8,12 235:4 276:13,22 16
predictive [1] 349:22 President-Elect [1] 7:16 285:16 303:22 355:10,16 proliferate [1] 111:6
predominantly [3] 41:13 73: press [1] 320:11 procedure [9] 21:3,19 22:4 proliferation [5] 111:5,11
5 281:9 pressing [1] 304:7 141:13 143:15 144:4 216:4 241:11,16 242:1
preeclampsia [1] 352:17 pressure [8] 121:3,3 137:6, 261:22 272:10 prolonged [5] 11:20 272:5
preemies [2] 307:14 330:14 11 190:3 254:1 257:11 295: procedures [16] 15:16 20:20 283:6 308:10 330:22
preemptive [1] 273:5 21 22:2 34:21 35:7,13,19 36:10, prominent [1] 78:5
prefer [1] 207:14 presumably [1] 221:2 12 53:13 72:3 109:17 142:20 promising [1] 228:20
preferably [1] 146:19 presumed [1] 263:2 264:4 317:4 330:18 promote [2] 230:11 358:7
preference [1] 336:1 pretraining [1] 127:4 proceed [2] 14:18 355:22 promoters [1] 324:15
pregnancy [27] 17:7 20:1,4 pretreatment [1] 208:10 proceedings [2] 199:14 217: promotes [1] 241:22
24:15 25:1,9,12,15 26:7,17 pretty [29] 36:9 42:14 76:2 81: 2 promoting [1] 116:1
27:9,13 69:4 108:15 110:16 22 119:14,18 124:12 128:10, proceeds [2] 52:16 347:18 promptly [2] 147:10 216:22
111:21 112:19 113:2 134:22 13 130:10 137:4 138:20 139: process [27] 15:22 43:21 51: promulgated [3] 31:6,17 32:
135:1,1 136:19 140:10 269: 16 152:1,17 153:5 191:21 8,12 77:17 78:11,19 80:2 81: 1
18 276:21 279:8 351:19 198:1 213:12 253:7 254:17 9 90:20 113:12,22 114:7 158: proper [1] 33:15
pregnant [22] 24:20 25:5,22 265:15 285:1,11 290:20 300: 12 186:20 187:5,14 218:8 properly [3] 36:6 117:18 206:
26:12 27:1 93:19 134:9,21 5 331:21 358:2 364:10 240:11 241:3,14,21 273:12 13
136:18,22 140:2 168:14 169: prevent [2] 146:7 311:7 274:12 288:2 339:9,10 properties [9] 76:20 83:12,
4 257:4,12,14 259:5,8,11 269: previous [8] 10:12 27:8,8 31: processes [3] 274:10 277:3 19 84:1,3,14,15 97:17 290:16
14 349:17 363:5 3 193:18 226:11 281:10 302: 339:6 Propofol [13] 30:17 88:1,2
preliminary [8] 12:11 93:8,10, 19 processing [6] 236:9 237:11, 231:13 250:19 251:7 252:15,
13 163:21 164:3 282:7 298: previously [7] 8:21 79:12 82: 13,19 238:17 276:12 18 255:9 298:4 304:13,14
13 5 129:2 189:2 262:14 266:6 produce [37] 44:5 49:22 53: 320:4
premature [10] 35:21 109:1,2 primarily [10] 24:3 49:18 50:4 18,20 54:1,22 56:13 58:15 proponent [1] 165:8
184:22 239:15 271:21 286: 51:15 93:12 177:20 294:15 60:1,10,16 61:1,3 62:4 63:16 proposals [1] 243:4
10 331:22 343:16 344:12 320:4 341:7 353:20 83:4,11,21 85:5,9 86:10 90: propose [1] 349:8
prematures [1] 330:14 primary [15] 42:9 45:20 52:6, 12 95:4 98:18 100:21 150:1 proposed [2] 44:14 281:17
prematurity [2] 196:21 275: 14,20 68:10 73:18 84:13 153: 156:10 178:17 194:19 204: propylene [3] 83:8 84:7,11
11 17 156:21 191:9 251:16 327: 20 233:14 236:10 265:3,4 prospective [2] 255:3 264:
premise [1] 208:18 19 345:4 364:16 271:3 341:10,11 17
prenatal [1] 191:21 primate [27] 12:9,12 46:16 47: produced [24] 51:21 52:9 55: prospectively [1] 359:18
preparation [2] 208:13 227: 4,15,18 48:6 93:14 102:5 11 56:14 61:21,22 62:7 64:1, protect [2] 130:8 154:17
13 134:1 156:18 158:4,16 160:7, 10,11,21 75:17 82:22 87:1 protection [5] 101:1 220:7
preparations [2] 227:9,10 16 163:21 167:14 176:14 89:9,13 99:21 103:11 104:8 292:3 293:21 304:8
prepared [1] 243:3 177:10 180:1,7 181:17 182: 106:20 229:16 231:15,21 protective [5] 231:14 335:16
Preschool [1] 345:22 10 203:15,16 282:12 301:3 233:5 337:11 358:6,6
prescribe [2] 223:12 225:18 primates [3] 93:4,7 263:18 producer [1] 83:6 protects [2] 129:8 294:21
prescribed [2] 220:19 221:1 principle [1] 126:7 produces [2] 195:1 331:17 protein [7] 155:12,14 230:16,
prescription [7] 220:2 221:9, principles [1] 359:1 producing [1] 177:9 20 235:11 236:10 289:3
12 222:1,12 225:1,7 prior [5] 33:8 81:13 234:10 product [5] 27:18 31:9 32:21 proteins [6] 131:14 155:7
prescriptions [1] 223:8 341:17,19 39:15 218:18 230:15,18 289:5 293:9
presence [4] 12:14 244:18 priorities [1] 341:21 production [6] 235:12 240: proteomic [1] 166:2
283:20 334:6 prioritize [1] 289:21 10,18 241:20 242:10 263:3 proteomics [1] 289:13
present [16] 9:15 13:8,21 14: priority [8] 326:7,11,14 329: Products [20] 5:11,21 6:2 10: protocol [14] 93:19 94:21 95:
5 68:13 96:20 144:18 147:21 20,22 330:6,11 332:19 5,13 11:16 13:18 20:17 23: 16 99:19 122:4,8,10 125:11
195:17 198:14 242:22 243: private [3] 201:10,10 249:15 17,20 24:16 27:16 28:3 29:7 130:5 137:16 143:17 258:12
11 261:13 350:10,18 351:2 privilege [1] 147:21 30:12 31:20 32:17 33:12 70: 295:19 305:14
presentation [12] 10:15 16:3, probable [2] 229:14,15 15 334:12 protocols [3] 97:13 118:10
protocols - recommending

135:17 pyramidal [1] 95:13 17 272:14 343:21 347:1 352: really [93] 15:6 50:9,14 51:1
protracted [1] 93:1 10 362:17 55:5 104:6,11,13 110:20 113:
proud [2] 146:6 210:4
Q randomizing [1] 200:21 4 114:6 118:1 120:22 122:15
prove [1] 29:6 quadrant [1] 128:6 range [19] 19:20 86:22 87:5 123:16 128:11 133:19 134:
proven [1] 243:1 Quality [3] 8:18 197:6 331:4 88:5 89:12 90:8 99:21 136: 12 135:11 139:17 143:9 145:
provide [14] 15:1,2,8 21:11 quantify [1] 138:1 18,21 137:3 151:3 159:3,9 14 147:20 148:1,22 150:19
33:12,15 40:3,7 69:12 111: quantities [2] 241:9,12 163:6 169:2 170:11 193:3 151:9 167:9,21 179:9 180:6
11 165:19 188:14 203:1 345: question
[76] 15:9 51:18 58:
206:10 350:12 181:13 208:15 210:15 211:1,
7 21 66:18 69:2,17 71:1 73:11 ranging [1] 37:20 4 213:14 214:3 215:1,12,17
provided 12:4 14:15 28:
[4] 85:20 86:11 97:7 100:2,10 rank-order [1] 231:5 251:7,22 252:6 254:13 255:
13 60:12 106:2 117:22 124:18,20 133: Rapid [2] 45:3 76:2 12,14 261:8 270:1 271:7 274:
provides [1] 77:4 19 139:14 156:16 194:14 rapidly [3] 90:20 226:15 289: 9,16 280:13 281:14 282:10,
providing 11:12 21:13
[4] 203:11 205:20 206:3,15 208: 20 15 285:3 287:10 288:18,22
260:7 292:2 1,17 214:8,9,19 221:13 230: Rappaport [14] 2:30 3:8 5:8, 290:1,9 297:22 302:15,17
provisions [1] 32:8 21 234:5 254:22 267:5,15 9,10 10:16,19 11:1 16:2 183: 305:13 308:13 315:6 317:15
psychiatric 38:21 142:6
[2] 268:22 272:9 274:1 277:9,22 6 311:4 344:16,20 365:9 319:20 320:1 321:15 326:16
psychological [3] 254:14 278:12 282:10,18 285:22 rare [1] 34:6 329:8 335:19 338:11,16 341:
316:22 317:10 286:8 288:8,20 294:14 301: rat [35] 42:8 43:5 46:8,17 48: 6 342:15 343:21 345:2 348:8
psychologist [1] 8:6 20 303:7 304:4 305:19 309:9 17,19 53:6,21 54:5 55:1 59:9 349:8 354:13 355:19 356:4
PTCC [1] 45:12 311:3 312:18 314:11,13 315: 62:16,21 63:4,8 65:1 77:4 357:2,6,12 359:19 360:11
PUBLIC [19] 4:2 14:11 29:1 10 326:7 333:1,8,9,15,17 337: 120:21 123:15 139:3 157:6 363:10,19
66:15 97:1 217:1 218:2,3,6,8, 2 341:2 342:22 346:18 349: 163:16 187:19 188:22 189:5, reason [9] 90:15 115:14 156:
10,15 219:9 222:6 223:18 15 357:20 361:3,10 364:2,3, 6 191:5 192:9 256:20 257:14 15 212:16 218:14 223:1 229:
265:7,9 266:15,18 11 258:8,20 269:3 298:14 314:1 20 230:3 355:9
public-health [1] 235:3 QUESTIONS [28] 4:21 12:18 rat-forebrain [1] 154:3 reasonable [4] 20:10 341:13
publication [7] 12:13 45:8 15:11 40:20,21 68:16,17 72: rate [10] 87:4,16 99:10,14 109: 348:12 356:6
54:10 65:15,19 70:16 247:8 18 73:20 99:7 135:3 147:2 1 137:11 166:19,22 222:8 reasons [6] 22:3 56:7 242:3
published [36] 11:5 19:1,3 182:19,20 203:9 243:9,14 360:3 268:16 355:11 364:16
41:14 42:2 45:20 46:3 52:7, 266:21 270:7,9 276:16 278:2 rate-limiting [1] 339:10 reassess [1] 20:14
18 54:5,20 59:6 65:5,14 66:8, 279:14 309:2,4,5,6 365:6 rates [3] 101:11,18 195:13 reassure [1] 306:15
9,15 67:5 86:19,20 90:19 quick [2] 127:7 363:13 rather [9] 30:13 39:6,15 54: reassuring [2] 354:5 363:12
135:4 141:6 145:6 149:18 quickly [11] 92:17,18 148:4 11 72:7 198:10 250:8 320:15 recall [8] 70:17 130:4 222:17
157:2 161:9 198:22 231:19 151:22 167:11 170:6 333:4 336:6 287:20 295:5 321:14 323:5
232:3 246:12 272:15 275:4 338:2,2 340:2 361:3 ratio [1] 234:13 344:17
299:9 314:3,20 quiet [1] 353:21 rational [1] 256:1 receive [2] 185:2 200:22
pull [1] 114:20 quite [40] 38:10 77:3 83:6 96: rats [44] 11:7 55:10 67:7 101: received [5] 38:1 221:19 232:
pulmonary [1] 21:9 8 108:12 109:20 111:5,13 5,10 112:7,16 113:6 118:19 17 272:21 365:11
pump 252:18 253:2
[2] 127:15,17 131:8,9 132:10,11 119:15,16,17,19 123:6,10 receiving [5] 271:12,17 327:
puncture [1] 120:16 138:22 139:3 141:14,16 143: 126:5,7 128:13 133:20,21 19 350:6,8
pup [2] 43:6 281:22 19 156:4 184:1 196:13 267: 136:9 162:16 192:2 193:5 recent [7] 14:2 34:5 208:9
pups 43:5 61:11 73:15,15
[9] 20 268:20 284:3 285:4 294:6 211:1,11,21 212:4 214:2,6 240:22 247:8 301:6 343:14
187:20 188:22 191:5 256:20 296:3 299:13 308:5 316:6 257:2,4,13 258:10 259:5,8,10, Recently [8] 12:11 19:1 65:
298:14 323:12 338:12 342:22 343: 10,11,13 283:18 296:19 298: 18 88:14 90:10 91:4 294:17
purchase [1] 121:6 12 345:3 350:13 354:5 355: 12 362:9 314:3
pure [2] 69:15 210:19 10 363:19 re-discuss [1] 183:8 receptor [33] 18:19 42:12 43:
purely [1] 69:8 quote [1] 183:17 re-dress [1] 303:17 8 46:1 48:11 50:22 51:19 66:
purpose [1] 261:2 R re-reading [1] 208:19 20 71:9 106:8,16 116:19 148:
purposes [1] 328:7 rabbits [1] 192:3 reach [4] 127:6 151:4 206:19 8,16 149:1 154:13,16 155:2,
pursue [6] 46:18 70:14 101:7 Rabinowitz [1] 269:5 258:15 18 161:14,21 162:1,5 174:19
271:2 292:19 293:15
race [1] 32:4 reached [2] 215:12 233:2 175:5 176:19 177:3 178:1
pursued [1] 47:22 racemic [2] 288:13,16 reaching [1] 232:12 186:19 240:13 283:4 297:2
pursuit [1] 294:12 Radial 126:4 128:12
[2] react [1] 73:15 338:9
push [2] 311:16 320:10 raise [6] 12:17 73:19 149:9 reaction [4] 26:9 80:15 98:9 receptors [12] 18:3 19:13,19
pushed [1] 283:21 306:19 311:7 313:4
115:16 39:11 75:18 76:14 98:3 148:
pushing [1] 52:11 raised 44:13 89:20 91:4
[8] reactive [1] 271:13 18 175:2 210:3,7 297:4
put [16] 114:8 121:12 126:11 92:15 107:6 220:10 281:16
read [4] 218:5 282:8 309:10 recessed [1] 217:3
134:15,16 161:8 185:16 191:
327:8
333:20 recognize [4] 143:1 202:1
17 263:8 303:16 305:9 312:
raises [1] 106:9 readily [2] 23:2 97:9 284:22 286:9
18 318:13 355:1 357:11 358:
Raja [12] 2:9 6:3,3 72:19,20 readings [1] 212:9 recognized [2] 103:18 178:2
17
267:5 288:7,8 312:12 315:21
ready [2] 221:9 286:5 recognizing [1] 317:17
putamen [3] 87:13 94:9,13 327:7 337:2
real [10] 97:2 102:1 135:6 172: recommend [2] 57:1 341:15
putative [1] 321:4 ran [1] 251:12 11 179:8 224:15 254:8,19 recommendation [1] 248:19
puts [2] 246:7 330:18 randomization 347:6 [2] 265:8 266:11 recommendations [3] 15:2
putting [3] 173:20 199:1 213: 351:6 realities [1] 222:20 30:2 244:10
2
randomize [2] 347:5,20 realize [3] 148:11 152:5 178: recommended [5] 25:14 46:
puzzling [1] 299:20 randomized [11] 184:22 185:
22 17 207:3 222:3,13
pyramid [1] 74:14 2 199:10 247:10 262:2 264:
realized [2] 143:3 178:8 recommending [1] 334:5
reconsider - risk

reconsider [1] 303:5 4,7 27:22 32:19 68:4 223:20 332:7 362:20 respond [9] 93:14 102:10
reconstruction [1] 347:15 Reid [3] 4:13 249:13,15 repairs [1] 196:15 158:1 240:13 275:2 277:12
reconvene [2] 333:3,7 reinfarction [1] 247:8 repeat [2] 311:10 354:18 283:10 342:1 343:11
record [6] 9:6 10:9 326:13 reinforcement [2] 291:2,6 repeated [12] 23:9 53:12,20 responds [2] 323:21 324:3
328:8 330:1 332:21 relate [8] 83:3 105:3 133:17 59:12 72:2,6 105:17 286:16 response [33] 11:22 36:2 41:
recorded [1] 121:19 163:14 169:22 281:10 289:5 319:8 329:2 340:15,22 1 45:3 50:9 51:16 61:2 64:21
recording [1] 122:1 318:9 repeatedly [1] 142:5 72:14 91:16 92:12 130:20
recover [1] 125:1 related [15] 16:20 32:19 34: repetitive [1] 144:5 131:4 154:1 158:5 186:5 194:
recovering [1] 250:12 12 37:11 38:14 102:1 241:4 replace [1] 255:13 11 201:19 281:18 287:18
recovery [2] 130:2 275:18 244:19 250:2 261:21,22 262: replicate [1] 149:12 308:7 310:5 317:10,11 328:
recreational [1] 226:17 7 325:11 331:17 348:21 report [8] 42:13 55:9 61:17 11,16,18 335:20 336:2,5,10
recreational-use [1] 226:9 relates [2] 269:22 288:10 63:22 64:16 65:13 66:8 145: 337:7 338:7
recruiting [1] 201:4 relation [2] 71:2 133:17 2 responses [9] 31:3 35:21 61:
recurrence [1] 247:1 relationship [7] 88:6 144:8 reported [25] 9:12 37:13,16 3 62:4 67:22 248:10 337:11
red [3] 48:12 168:15 219:13 218:17 234:19 237:4 256:10 39:5 44:5 46:7,10 53:14 57: 341:10,11
reduce [7] 89:5 188:12 236:8 278:22 22 59:4 60:4,14 62:6,9 63:11 responsibility [3] 221:13,16
238:6 242:14 244:2 273:6 relationships [4] 219:5,7 65:5 67:12 72:21 73:6 88:14, 225:5
reduced [5] 36:2 77:6 89:1, 342:16,17 18 90:10 91:5 100:11 189:2 responsible [3] 182:5 232:4
10 276:12 relative [6] 19:4 76:4 205:4 Reporting [2] 36:21 37:1 237:22
reduction [1] 322:17 223:14 246:5 266:22 reports [7] 11:9 26:21 38:17, responsiveness [2] 154:13
reductions [1] 275:7 relatively [19] 14:1 17:2 27: 22 39:8,9 235:19 172:4
redundant [1] 113:15 13 65:9 85:4 121:9 136:21 represent [5] 9:22 22:21 43: rest [3] 98:9 167:21 177:6
reemphasize [1] 340:12 142:14,19 144:4 152:22 164: 13 224:10,15 restraint [1] 261:12
refer [2] 111:1 228:14 15 167:10 170:6 204:14 261: representation [1] 101:19 restrictions [1] 265:18
referenced [1] 246:1 2 263:10 305:7,9 Representative [4] 2:15 8: result [5] 85:16 107:8 177:14
references [1] 141:5 relatives [1] 220:15 22 9:19 340:21 207:19 258:5
referred [3] 16:22 36:20 115: relaxant [1] 184:14 representing [1] 44:20 resulted [2] 63:5 150:20
14 relaxation [3] 252:16 253:10, reproduce [1] 82:16 results [7] 12:11 44:5 62:20
refining [1] 349:7 22 reproduced [1] 64:3 128:14 157:18 177:14 353:
reflect [2] 187:11 204:17 release [16] 17:18 130:21 reproducible [1] 46:9 18
reflected [1] 216:17 161:1 226:4 227:9,10,12,12, reproduction [2] 25:3 26:4 resumed [1] 217:3
reflecting [1] 48:21 14,14,22,22 228:8,8,10,10 Reproductive [1] 161:10 retain [1] 18:11
reflects [2] 27:15 223:18 released [1] 226:14 request [1] 248:20 retardation [2] 105:13,15
reformulated [1] 222:18 relevance [6] 11:11 40:5,15 require [17] 15:17 27:17 32: retested [2] 127:12,13
Reformulation [1] 222:19 186:16 239:12 350:4 14 56:7 58:12 92:21 170:13 retrospective [1] 142:16
refuge [1] 126:17 relevant [13] 56:16 102:5 118: 184:4 191:5 216:11 223:10, retrospectively [1] 359:14
refute [1] 162:9 8,9 125:12 188:2 236:5 250: 20 270:15 332:10 340:16 retrosplenial [1] 258:1
regard [3] 39:20 67:21 165:3 5 277:21 280:9 329:9 333:12 348:1 351:6 return [3] 216:22 247:15 315:
Regarding [18] 3:9 12:18 14: 337:5 required [14] 28:12 29:6,11 17
20 15:2 16:4,7 24:10 27:12 reliance [1] 242:18 31:18 32:2 33:8 60:21 74:13 reversed [1] 295:3
44:14 49:21 130:21 213:6 relief [1] 21:14 85:15 95:4 144:5 156:17 184: reversibility [2] 165:10,11
220:2 224:14 244:5 248:16 relooking [1] 202:12 8 214:21 review [9] 13:16 45:22 46:3
341:5,12 rely [1] 30:13 requirement [2] 29:10,15 100:19 185:16 227:17 243:5
regards [5] 45:20 56:2 227:1 remain [4] 23:13,19 242:22 requirements [4] 27:22 34:3 250:14 359:14
297:2 319:15 270:9 185:7 190:7 reviewed [8] 47:12 49:20 135:
regimen [8] 42:17 54:13 60: remainder [1] 14:13 requires [4] 24:16 273:17 5 168:2 227:17 228:5,6 245:
14,20 67:15 71:11 309:18 remained [1] 90:8 279:4 337:8 14
311:14 remains [3] 124:18 241:16 requiring [1] 273:19 revoked [1] 31:3
regimens [2] 33:18 349:6 245:1 rescue [1] 126:17 revolutionary [1] 29:9
region [10] 81:21 82:6 94:14, remarkably [1] 80:14 RESEARCH [24] 1:3 5:16 9: Rhesus [8] 48:19 49:8 65:21,
17 96:7,10 200:18 225:16 Remarks [2] 3:7 10:22 15 12:2,3 29:18 30:6 32:14, 22 102:7 156:15 164:14 166:
226:7 278:8 remember [4] 126:16 203:18 15 35:14 44:21,22 45:2,9 48: 8
region-specific [1] 299:14 204:10 269:17 2 65:17 97:6 147:16 266:9 Rheumatology [3] 5:11,20 6:
regional [7] 34:20 114:9 246: remembered [1] 63:2 298:7 310:16 313:6 325:11 2
18,21 262:2 279:19,21 remifentanyl [1] 323:11 333:1 Rich [1] 125:15
regional-anesthesia [1] reminder [1] 224:13 researchers [1] 16:11 rid [2] 113:16 161:19
280:11 reminds [1] 124:14 researching [1] 348:16 rigorous [1] 34:5
regions [4] 51:2 77:18 96:4 remote [1] 25:11 resection [1] 21:8 rise [2] 29:1 170:6
140:8 removal [1] 43:14 reside [1] 220:9 rises [1] 186:5
registry [2] 199:1 316:12 remove [5] 94:6 95:7 128:3 resident [2] 108:17 250:8 risk [44] 20:10,11 22:4 24:22
regressive [1] 144:17 161:19 199:10 resilience [1] 357:21 25:1,7 26:1,8,13,20,22 55:19
regular [1] 212:21 removed [6] 51:10,11,13 91: resolve [1] 97:6 72:1 104:3 228:15,17 241:18
regulated [2] 9:14,20 18 223:1 251:10 resounding [1] 226:2 246:4,6 247:13,21 248:1,15,
regulation [5] 27:16 29:2 30: removing [1] 361:7 resources [4] 134:3 265:7 18 267:2 271:21 278:5 286:
13 31:18 292:1 renal [1] 110:6 326:9,22 14,19 287:9 293:5 313:5 329:
Regulations [2] 24:15 31:6 render [1] 225:2 respect [2] 10:10 140:22 6,14 330:18 331:10 339:18
Regulatory [8] 3:9 13:16 16: repair [5] 240:11,16 286:12 respiratory [2] 120:11 196:7 344:10 346:22 347:1 350:1
risk - Sevoflurane

362:5,8,15 207:17 214:5,22 216:2,11 sedated [1] 272:6 selected [3] 31:19 262:19
risks [9] 15:19 26:13 223:14 223:3 227:21 231:17 258:6 sedating [1] 143:6 360:19
227:11 228:12 364:3,7,13,15 268:10 278:3 284:9,10,11 sedation [12] 35:2,9 40:3 86:selecting [1] 357:5
road [1] 181:13 285:21 288:2,3 295:8 296:14 10 135:17 143:2 197:16 273: selective [1] 281:6
Robert [1] 2:29 297:4,11 301:5 305:14,18 20 283:6 308:11 322:17 328: self-signaling [1] 107:6
robust [2] 83:6 361:1 314:11 354:20 362:12 5 Senior [2] 8:6 13:7
robustly [1] 77:3 samples [2] 168:19,21 sedative [7] 11:15 12:19 19: sensation [1] 35:15
Rockich [1] 115:21 San [1] 248:8 13 34:16 135:22 273:13 349: sense [16] 70:4 134:7 157:12,
Rockville [2] 1:10,11 Sands [1] 191:16 6 16 164:19 204:21 206:11
Rod [1] 229:7 satisfactory [1] 97:15 sedatives [1] 22:7 234:7 278:14 295:2 301:11
rodent [25] 11:13 12:5,16 35: saturation [6] 90:6 137:7,7 see [165] 43:12,12,16 49:10 304:14,15 325:18 335:4 364:
17 61:18 76:5 90:18 93:15 167:19 168:9 190:3 54:7 67:6,8,9,18,19 70:3 71: 19
107:15 150:2 156:18 157:10, saturations [2] 100:12,14 5,18 77:13 78:3,19 80:11,17 sensitive [26] 56:5,10 97:3
19,22 158:4,16 160:7 170:1 saw [9] 111:9 152:9 206:8 81:3,18 94:10 96:16 109:2, 103:3,4,7,9 112:14 143:13
177:20 182:10 204:12 207:6 215:14 301:22 335:15 354:7 14,18 115:8 119:17 120:8 144:20 150:4 154:5 162:17
293:17 294:5 315:5 362:9 363:9 121:21 123:4,17 124:12,19 163:4 164:6,9 176:3,10 178:
rodents [5] 11:21 17:3 151: saying [6] 206:11 297:15 302: 127:2,20 129:20 130:6 131:7 11,14 179:9,11,17 278:10
13 277:16 290:19 16 310:17 342:10 356:22 132:2,9,10 133:7 136:21 137: 285:6 363:1
Roderic [1] 4:7 scale [2] 48:19 92:15 4 138:3,7,12 139:8,10 145:2 sensitivity [8] 103:1 122:9
role [8] 9:21 27:15 28:21 46:2 Scallet [4] 46:10 59:6 72:21 149:14 150:8,17 151:18,21 163:13 164:8 178:5 179:10,
148:9 191:12 221:14 293:19 149:19 152:13 153:7 154:4,9,14 156: 13 204:17
room [15] 133:12 136:5 137: scans [1] 270:13 5 157:7 159:1,21 160:8,21 sensory [6] 282:20,22 283:5
13 148:8 178:22 187:12 188: scattered [1] 81:3 162:8 165:15 168:4 169:1 284:13 285:16 287:18
11 189:10 249:21 253:18 scenario [3] 60:6 73:1 244: 170:3,5,8,10,15,19 171:6,15, sentinel [1] 186:13
301:21 330:17 334:2 358:18 20 16,19 172:8,11,16 173:2 174: separate [3] 210:11 258:8
363:18 scenarios [1] 292:3 5,20 175:1,20 176:1,5,6 178: 269:6
ROSTER [2] 2:1 6:21 scene [1] 123:14 18 179:12 185:18 187:11 separately [1] 209:17
roughly [3] 94:2 99:14 264: scent [1] 285:17 188:20 189:21,22 192:5,13 septic [1] 184:8
12 schedule [6] 147:5 182:17 195:11 197:21 198:3 202:2, sequelae [2] 142:2,3
route [2] 23:6 304:11 219:16 222:5 225:6 301:21 16,19 205:8 206:5 207:4 209: sequence [1] 173:11
routine [1] 188:13 scheduled [1] 307:15 10 210:8 211:5 216:18 219: serial [1] 94:18
routinely [2] 108:10,20 schedules [1] 16:1 11,13 220:12 223:16 229:19 series [5] 98:5 204:19 230:19
row [1] 95:20 scholarly [1] 250:14 236:14 237:8 238:5 244:17, 246:7 251:1
RSV [2] 271:14 347:17 Schoo [1] 4:9 20 246:14,19 247:4 251:22 serious [2] 26:14 302:13
Rubsamen [5] 4:13 249:13, School [4] 4:18 7:15 211:16 252:13 255:4,6 256:1 262:13 seriously [2] 222:3 239:15
14,15 256:7 228:22 263:10 264:5,10 266:10 268: serum [2] 338:1 351:1
Rudin [1] 64:15 Science [6] 11:6 42:3 53:7 5,5 288:2,4 289:11 295:9,22 serve [2] 240:2 249:21
rule [4] 25:14 31:18,22 32:2 102:1 306:4 330:7 296:13 297:11 299:14 301:9, SERVICES [1] 1:1
rules [3] 29:14 243:13 314:16 Sciences [12] 8:17,19 12:13 17 321:15,17 328:12 332:5 session [6] 217:1 218:11 243:
run [1] 265:9 29:18 30:3 45:1 46:6 58:4 336:1 346:13 347:7,9 349:4 13 281:20 289:7,8
running [1] 10:20 149:19 157:3 168:1 175:10 352:11 354:4,19 355:7,12 set [9] 16:12 28:13 120:1 148:
Ruth [1] 317:2 scientific [2] 93:9 309:6 356:7 357:1 365:2 3 165:11 196:22 224:12 236:
scopolamine [1] 143:2 seed [1] 201:10 2 353:7
S score [5] 197:22 263:8 345: seeing [16] 42:2 43:1 105:19 sets [1] 288:18
sacrificed [1] 114:10 21,22 346:1 151:12 152:15 156:2 159:11 setting [22] 14:6,21 15:8 22:
safe [6] 24:10 28:12,13 186:8 scores [1] 123:2 160:18 203:17 248:4 276:18 20 55:5 57:4,8,15 68:3 117:
242:12 278:19 Scott [2] 4:11 243:16 277:1 310:16 330:15 334:8 22 120:17 136:5 137:13 149:
safer [6] 26:15 27:2 40:11 screen [1] 220:13 335:10 13 189:11 271:4,6 299:4 323:
307:21 309:18 311:14 se [5] 141:3 215:9 261:21 317: seem [7] 146:7 179:17 181:7 13,13 334:12 342:14
safest [2] 302:12,22 16 338:9 216:3 289:4 330:5 361:1 settings [1] 313:3
safety [26] 20:9,15 23:21 28:8 search [2] 141:4 164:10 seemed [2] 216:9 362:10 setup [1] 286:1
29:4,20 31:9,20 32:3,6 33:11, Seattle [1] 8:4 seems [28] 17:2 69:22 72:8 seventies [1] 184:2
18,21 40:1 44:10 97:14 206: second [16] 17:5 25:8 61:10, 113:19 150:4 177:1,19,20 several [26] 30:15 34:9 42:2,
11 223:18 227:8,11,15 228:1, 18 91:3 94:2 100:10 112:17 179:11 203:21 205:6 246:21 16 67:12 76:7,12,13 85:7 93:
3 248:20 304:8 322:6 124:13 142:9 269:17 324:6 256:1 263:4 269:8 278:13 21 148:1 150:7 153:21 156:7
salicylates [1] 241:19 325:8 332:9 356:20 365:15 284:2 289:8 293:19 297:3 164:3 178:2 182:7 185:6 200:
saline [14] 43:7 53:11 59:12 Secondly [1] 133:14 298:15 299:1 305:12 320:11 17 222:13 227:4 235:19 264:
80:21 94:13,14,15 95:10 96: seconds [1] 219:12 325:1 354:22 356:11 360:6 8 272:10 358:11 361:11
12,16 124:7,8,9 284:5 Secretary [2] 2:3 29:14 seen [23] 11:20 12:16 36:16 severe [7] 105:12,19 106:1
saline-treated [2] 77:12 87:9 secretase [1] 238:16 108:5,12 112:2 129:2 139:5 121:14 142:3 223:5 303:9
same [69] 21:17 23:8 29:3 30: section [7] 21:18 31:7 49:15 142:5 148:17 151:4,15 181: severely [4] 105:16 119:21,
3 69:21 70:1,5 78:1 80:16,19 94:6,19 95:7 350:19 14 191:16,17 211:10 224:14 21 273:10
93:14 94:13 95:16 99:21 122: sectioned [2] 78:4 352:21 226:7 248:15 275:17 276:7 severity [1] 122:13
10 123:6,7 127:11 128:7,14 sections [5] 48:13 81:12,14 319:15 329:8 sevo [3] 255:14 355:4,14
130:5,10 141:12 143:15 150: 82:6 352:16 segments [1] 33:16 Sevoflurane [19] 31:11 201:1
15 156:9 157:19,20,21 158: secured [1] 32:22 seizures [1] 197:18 213:5,12,16,18 214:6 244:19
12,13,17 159:9 165:3 169:6,9 sedate [2] 188:9 202:22 select [2] 225:20 351:18 250:22 253:4 296:13 298:3
170:11,14,16,19 172:1 191:5
Sevoflurane - sort

318:19 320:6,18 337:18 338: 233:16 246:6 262:20,22 274: 231:8 268:11 279:13 293:2 182:15 203:8 204:9 206:14
13 353:20 354:3 14 276:22 296:4 343:12 336:6 338:21 214:17 215:17 266:22 267:6
Shafer [108] 2:2 3:3 5:3 7:2,2 shown [24] 25:4,6,19 28:12 sites [3] 267:10,11,12 270:8,15 288:15,21 289:11
11:2 16:2 40:19 41:2 68:15 40:11 50:7,19 67:7 90:1 94:9 sits [1] 192:1 291:22 293:6 294:4 340:3
70:21 71:16 72:18 73:11,22 115:3 116:17 117:4 171:8 situation [10] 26:14 37:8 40:8 356:9,10
99:6,22 100:17 102:10 103: 187:6 192:12 193:18 194:20 159:18 162:3 163:17 169:22 Slikker's [1] 256:15
13 106:2 107:18 146:22 147: 208:10 211:11 237:2 269:6 180:1 294:7 331:5 slow [5] 128:14 130:2 170:6
12 182:15 198:21 203:4 205: 278:6 304:14 six [3] 32:10 219:17 246:12 262:16 361:14
19 214:6,8 216:20 218:3 224: shows [6] 27:7,21 36:2 174:6 six-month [1] 31:14 slowly [3] 53:1 92:20 93:1
17 229:6 234:15 239:18 243: 231:14 286:20 sixth [1] 151:20 small [15] 75:2 104:3,9,14,17
12,18 249:12 256:7 260:16 shrink [1] 18:12 sixties [1] 184:2 107:14 109:8 110:2 120:20
266:13 277:11 278:1,12 279: shunt [1] 21:10 size [6] 110:19 111:9 246:8 121:6 187:18 195:11 225:11
14 283:9,12 286:7 288:7 294: shunting [1] 21:7 339:5 351:19 356:6 246:7 356:12
13 295:9,13 297:14 301:8,15 sick [1] 195:11 skill [1] 276:4 small-size [1] 132:22
305:18 306:17 309:3 310:4,6 sicker [1] 287:5 skills [1] 199:22 smaller [3] 70:5 133:3 141:9
311:6 312:7,13 313:19 315:8, sickest [1] 344:11 skin-breaking [1] 317:3 smell [3] 284:19,20,20
12,17,22 318:1 319:10 321:6, sickle [1] 277:3 slap [1] 143:4 smile [1] 301:19
21 322:20 323:16 324:21 side [6] 80:15 124:7,11 316:2 sleep [1] 143:5 smoothed [1] 253:15
326:6 327:5 328:7 329:13,17 322:6 350:10 sleeping [1] 28:18 Snodgrass [16] 2:23 8:10,10
330:10 332:14 333:7 334:4,8 sign [1] 134:19 slice [2] 43:5 361:7 106:3,4 107:4 292:20 300:18
335:13 339:21 340:11 341:1, signal [15] 40:1 116:7 321:7, slices [4] 54:18 268:1,12 287: 311:21 313:10 322:20,21
22 342:18 345:11,14 346:17 18 323:3,4 325:2,5,6 330:3,3 21 328:1 337:14 339:4 340:13
349:15 353:10,16 354:1,7 347:9 354:4,7 363:12 Slide [194] 16:18 17:14 18:21, snort [1] 226:10
356:9 357:15 358:8 361:4 signaling [3] 18:2 338:11 22 20:7 22:15,18 23:8,10,11, Society [5] 7:11,16 198:19
362:2,16 365:15,18 339:11 16,17 24:13 27:6,7,20 33:1 199:3 281:20
Shakes [1] 301:14 signals [3] 97:19 98:5,20 34:14,18 35:5,11 36:14 38: sodium [16] 82:21,22 83:21
sham [5] 135:8,10,11 139:9 signature [1] 289:5 11 39:7,12,22 41:10,22 42:21 210:13 279:16,17 280:1,15,
321:10 significance [2] 41:21 125:4 43:16 44:11 45:18 47:10 48: 18,19 281:3,4,9,12 327:8,10
shams [1] 139:22 significant [28] 30:21 37:18, 7,8 49:15 50:1 52:4 53:15 54: solely [2] 30:13 208:22
shaped [1] 96:7 22 42:14 85:22 86:12,15 87: 3,19 55:15 58:22 59:20 61:5, solubilized [1] 84:11
share [2] 244:4 266:16 2 88:7 89:4,9,13 91:22 92:5, 15 62:14,19 63:12,21 64:14, soluble [2] 84:9,10
sharp [2] 64:5 150:3 9 108:5 130:7 131:2 132:20 19 65:11 66:11 69:18 74:10, solution [2] 97:10,15
shebang [1] 346:6 138:9 168:4 234:6 247:13 17 75:15,19 76:8,16 77:1,9 solutions [1] 97:9
shed [1] 146:13 258:18 268:15 272:8 321:15 78:7 79:9 80:8,18 81:8 82:13 solvent [3] 28:6 83:5 84:14
shock [1] 184:8 331:10 83:9 84:16,19 85:1,18 86:6 solvents [3] 83:2 84:4 250:10
short [8] 133:15 142:19 144:4 significantly [6] 140:12 229: 87:6,17,22 88:9 89:15 91:2 solving [1] 145:8
223:16 224:12 259:20 360: 4 258:2,19,21 259:12 92:13 93:16 94:20 95:14,19 somebody [2] 141:20 265:12
16,22 signs [5] 78:18 121:2 131:7 96:2,14,19 97:8,21 98:1 100: somehow [2] 131:18 270:6
short-acting [1] 282:1 137:9 295:22 19 108:3 109:9 110:7,22 112: someone [1] 335:3
short-term [4] 251:17 254:18 silver [6] 77:21 123:20 167:2 1 113:10 114:13 115:19 117: someplace [1] 338:10
255:19 290:15 172:14 175:12,16 1 118:3 119:8 120:19 122:5 sometime [1] 180:13
shorter [3] 136:7 172:22 178: similar [25] 12:16 43:2 44:5 123:12 124:5,17 126:1 128: sometimes [7] 84:8 105:12
16 62:4 63:10 90:11 117:9,13 16 129:3,19 130:13 131:5,11, 138:12 209:22 284:16 305:3
shortly [3] 6:21 59:18 169:17 130:22 138:18 143:17 158:2 20 132:7,13 134:5 136:15 339:16
shot [1] 133:13 209:10 211:2 251:2 258:12 137:14 138:16 139:1,11,13 somewhat [4] 106:22 318:16
shouldn't [1] 229:20 260:4,8 263:10 273:12 279:5 140:18 142:8 143:18 144:21 347:13 351:10
show [36] 36:4 78:2,11,12,16 282:14 291:5 338:13 355:13 145:12 148:6,14 149:6 151:6 somewhere [3] 76:6 154:21
90:12 93:6,10 104:18 113:18 Similarly [2] 35:6 318:22 152:19 153:13 154:2,12 155: 163:4
120:17 126:22 151:2 155:9 Simone [13] 2:33 3:11 5:22, 3,20 156:12 158:18 160:5,12 soon [2] 137:20 168:1
166:4 167:18,19 171:2 191:3 22 13:20 16:6,9 40:19,21 41: 161:7 162:10 163:18 166:6 sophisticated [1] 186:9
194:18 196:1,12,17 199:22 2 50:10 71:6,12 168:7 169:18 172:6,13 173:5, Soriano [42] 2:10 3:26 7:13,
202:13 233:16 234:4 256:22 simple [6] 118:5,11 221:7 18 174:14 175:7,8 176:15,22 14 13:9,11 14:10 22:14 36:7
265:2 266:4 278:18 295:7 230:20 242:12 285:15 177:12 178:7,20 181:11 182: 53:5 69:13 89:18 109:12 140:
309:12 310:1,3 357:21 simplistic [5] 109:7 112:4 3 183:15,20 184:10,17 185:9, 19 146:12 182:22 183:5 203:
showed [31] 35:21 64:5 77: 210:1 286:10 296:8 21 186:12 187:1,8,16 188:3 4,8 208:4 266:22 271:19 273:
22 98:2 99:9 117:8,11 128: simply [14] 51:11 52:10 54:11 189:3,15,20 190:21 191:15 9 281:18 286:9,18 298:6 302:
13 140:1 152:6 155:5 175:4 55:7 57:11 96:21 124:3 159: 193:6 194:13,16 195:9 196: 6 303:3 305:2,18,21 312:4
186:1 187:3,5 189:17 193:13 1 162:21 210:10 275:11 304: 10 197:7,20 198:11 199:13 313:16 317:13 319:20 322:
198:7 204:11 211:1 213:15 16 317:13 354:19 200:8 201:12 202:8 231:1 14 334:13 343:11 344:19
231:17 236:20 256:18 266:6 simulate [1] 284:6 slides [5] 23:9 27:8 114:17, 345:3,18
281:21 296:15,18 343:17 since [11] 11:18 45:7 46:13 17 148:5 Soriano's [1] 271:8
346:7 353:8 66:17 70:10 134:1 148:3 225: slight [2] 64:1 122:2 sorry [1] 345:11
showing [31] 23:13,20 78:21 13 226:21 250:7 281:16 slightly [4] 49:12 96:7 186:4 sort [40] 151:8 153:14 155:4
80:21 90:5 94:16 95:9,13 96: single [24] 53:12,17 59:14 60: 318:14 157:13 160:13 161:1 164:19
3,6,9,11,13 99:16 124:15 130: 9 71:22 72:7 85:11 86:9 100: Slikker [33] 2:31 3:23 5:14 13: 169:21 170:14,19 173:20
8 154:12 155:12 158:12 160: 4,4 103:21 104:2 134:19 150: 9 14:10 48:3,8 65:16 66:10 175:10,15 180:21 181:12
10 161:12 224:12 232:17 17 188:8,15 190:1 212:18 69:11 99:15 147:13,14,20 203:22 204:18 206:10,15
sort - sub-Q

216:13 250:20 265:15 270: sponsoring [1] 239:22 220:14 321:12 237:4 281:13 283:13 295:15
21 273:22 274:9 293:18 301: sponsors [3] 27:18 32:15 57: steady [1] 215:12 299:18 316:17 325:13 336:2,
11 309:5 316:2 319:7 336:6 2 steady-state [1] 94:3 4 358:5
342:19 347:3 348:15 356:10, spontaneous [2] 258:2 259: steep [1] 204:14 Studies [173] 3:21 11:18 12:7,
14 359:19 361:4 363:7,11 5 step [1] 339:9 12,14,16 13:2,6,8 14:6,18 15:
sought [1] 142:4 spontaneously [1] 254:20 stepped [2] 87:11,15 1 19:3,9 23:21 24:20 25:3,5,
sounds [1] 282:16 spot [1] 128:7 steps [3] 41:19 177:8 178:15 13,21 26:4,5,10,18 29:9 31:
sources [1] 182:9 spots [1] 43:11 Steve [3] 7:2 183:5 351:13 16,20 32:11 33:2,5,13 34:1
southwest [1] 225:11 spread [1] 225:17 Steve's [1] 337:6 36:17 41:13,15 42:16 46:15
span [1] 119:14 sprinkling [1] 77:14 Steven [2] 2:2 3:3 47:4,20,22 48:6 52:6,18 55:4
spans [1] 17:6 spurt [4] 17:1,4 76:1 111:2 Stevenson [1] 316:10 57:3,22 59:2 61:7 63:13 64:
spare [1] 21:1 spurts [1] 110:15 Steward [1] 228:19 15 66:16,16 67:12,20 68:2,5,
spared [1] 224:7 Srinivasa [2] 2:9 6:3 stick [4] 238:4 239:3,3 278:21 11,18 72:21 73:2,13 79:13
sparked [1] 55:16 St [3] 4:5,6 84:22 stick-together [1] 238:5 90:19 97:11 101:21 102:4,5,
sparse [3] 81:3 87:13 94:16 stability [1] 57:10 stickier [2] 230:18 231:1 15 104:19 106:11 107:12,15
spatial [1] 126:5 stabilize [1] 98:15 stickiness [1] 230:20 117:7 120:18 125:16 145:16
spatial-reference [2] 258:22 stable [2] 164:2 206:19 still [21] 40:7 65:3 73:20 89:7, 146:9,17 147:18 152:18 153:
259:9 Staff [1] 8:7 12 98:20 103:6 116:12 127:9 12,16,17 158:9 160:14,14
SPEAKER [10] 2:26 107:20 stage [14] 14:7 16:13 102:18, 143:19 176:17 188:20 202:3 163:12 166:8 171:3 175:11
147:12 182:22 218:15 224: 19,20 103:9 115:6,7 120:1 244:14 253:4 273:14 282:7 180:9,15,19 182:2,10,11 184:
18 229:7 234:17 249:13 256: 148:3 164:6 170:16 214:22 287:11 314:12 346:14 363:4 18 191:19 194:18 195:22
8 332:9 stimulants [1] 327:18 196:16,20 197:10 198:8 199:
speakers [9] 182:21 219:9 stages [4] 102:16 164:17 178: stimulated [1] 273:22 8 202:18 208:9,15 210:6 211:
266:14 282:10,18 283:9 301: 9,12 stimulation [8] 18:1,18 68:19 1,6 213:11,15 215:6,9 223:13
9 309:7 365:13 stain [5] 77:21 167:2 172:14 193:9,21 194:10 283:20 317: 231:7 237:2 239:12,14 240:
speaking [5] 20:18 175:11 175:13,16 18 22 248:20 256:3,22 262:1
219:8 271:19 344:1 staining [13] 43:10,20 77:22 stimuli [1] 240:18 265:2 267:16,21 268:7,14,17
speaks [1] 340:14 80:9 81:1 87:12 95:22 96:5 stimulus [6] 92:17 190:18 270:10 272:7 274:12 276:9
Special [4] 83:13 222:5 235: 123:20,20 137:22 138:13 193:11 333:22 334:1,2 278:3 279:17 281:11 282:12,
11 327:22 354:17 stop [1] 239:16 13,14 289:21 291:12,19 292:
specialized [2] 190:1 223:10 stains [3] 77:21 78:2 123:21 store [1] 134:12 5,21 297:22 298:1 302:15
specialty [1] 308:15 stand [3] 40:1 263:9 322:14 story [2] 114:14 228:16 304:13 305:12 316:8 321:7
species [38] 17:3 48:22 49:14 standard [5] 78:9 159:7 170: straddled [1] 198:2 333:12 334:5,16 336:7 340:
56:2,5,8,11,12,13,20 58:10 7 197:15 215:19 straddles [1] 192:9 18 341:17 343:13,20 346:2,3
61:10,18 67:7 76:4 101:9,10, standpoint [3] 280:12 307: straggling [1] 82:1 349:14 350:21 353:8,18 354:
11,13,20 102:8 112:5 113:5 22 330:13 straightforward [1] 261:3 2 359:2 361:2 362:4,9 363:5
136:11 162:13 166:10 190: stands [1] 77:20 strategies [2] 180:22 222:14 study [104] 25:19 29:16 30:1
22 191:20 207:4,9 215:7 271: Stanford [1] 7:3 strategy [1] 359:11 33:8 36:4 44:15 47:7 56:21,
4 290:11 291:9 315:1,2 357: Stanford-Binet [1] 348:11 stray [1] 198:3 22 59:17 60:12 61:9 64:20
7,8 starred [1] 200:10 street [2] 83:14,14 69:18 70:11 77:22 84:21 85:
specific [22] 9:10 23:12,18 start [21] 5:8 23:14 28:4 99:8 stress [17] 35:21 36:2 181:7 6 87:18 88:11,21 89:2 90:5
24:6 81:5 225:7 244:6 270: 116:3,8 137:20 151:9,18 152: 186:4,5 194:10 201:19 240:4, 94:18 95:2,7 99:9 101:7 102:
17 276:13 282:20 283:6 294: 15 156:5 159:21 164:11 176: 5 241:4,13 242:11,14,21 243: 15 103:20 115:1 117:10 118:
20 297:7 303:4 334:22 348: 12 209:10 216:22 266:20 4 260:10 293:19 4,5 125:6 132:14 140:11 141:
21,22 349:5,8 358:12 359:4, 309:3 311:17 342:3,4 stressful [2] 35:19 240:18 6 142:9,11,16 143:20 151:1
17 started [8] 85:19 129:18 143: stressor [1] 317:10 159:10 160:16 165:17 166:3
Specifically [15] 23:4 29:12 6 201:4 267:15,22 285:14,19 strictly [1] 37:1 188:4,6 197:17 199:11 201:9
34:12 38:19 48:12 49:18 211: starting [4] 135:19 181:16 striking [1] 247:6 204:12 206:9 209:12,14 211:
4 225:4 234:5 245:5 246:8 291:15 341:17 stripping [1] 78:16 11 212:10 213:8,10 216:12
280:20 317:3 318:3 360:21 starts [4] 49:5 78:21 110:15 strive [1] 146:5 236:2 239:11,11 246:1,19,20
speck [1] 94:10 126:14 strong [1] 324:15 247:17,22 248:6 257:9 266:6
spectrum [1] 337:19 State [12] 7:9 58:16 98:4 130: stronger [1] 29:1 268:19 269:22 272:22 275:4
speculation [1] 69:15 1 164:2 169:6,13 197:2 215: strongly [2] 19:18 222:13 277:20 281:15 287:1,16 295:
speed [1] 276:12 12 233:5 307:7 342:9 struck [3] 71:1 73:12 250:9 7,8,11 296:17 299:9 316:6,9
spend [1] 125:22 state-of-the-art [1] 304:17 structural [1] 148:12 320:17 322:13 327:4 333:22
spending [1] 306:4 stated [1] 31:8 structure [2] 74:16 251:3 336:14 343:2,14,22 344:17
spent [2] 128:5 244:11 Statement [13] 3:4 9:2,3 218: structures [4] 79:1 81:19 345:20 347:22 348:5 356:6
spherical [1] 78:21 16 219:3,8 221:20 222:2 309: 138:4,21 359:13 360:12 361:6,8
spinal [11] 200:22 247:13 278: 10,14,15,16 310:21 struggled [1] 212:5 studyable [1] 101:4
4,4,8 280:2,2,19,21 329:6 States [4] 27:19 235:4 325:16 struggling [2] 103:15 127:9 studying [13] 84:5 85:19 88:4
349:20 351:15 stuck [1] 355:21 119:2 275:10 277:17 334:21
spoke [4] 162:11 179:19 181: stating [3] 31:6 206:1 332:20 studied [39] 75:20 76:9,11,13 335:9,22 336:10,22 337:3,5
1 193:9 statistically [2] 138:9 234:6 77:2 78:8 79:10 81:9 82:14, stuff [3] 251:5 298:9,9
spoken [1] 292:7 statistics [1] 224:13 19 83:6 85:3 86:7 88:1,10 91: sub-anesthetic [2] 86:8,14
sponsor [2] 33:7 218:18 status [1] 37:7 17,20 93:20 94:15,18 99:16 sub-MAC [2] 89:8,12
sponsor's [1] 218:21 stay [2] 134:18 140:2 119:9 122:6 134:22 135:1 sub-optimal [1] 364:5
sponsored [1] 198:17 staying [4] 133:10 182:17 138:4 142:17 143:22 211:3 sub-Q [2] 44:3 342:12
subanesthetic - therapy

subanesthetic [2] 190:15,19 Sul [5] 7:13 22:13 182:22 307: 141:22 338:17 Team [1] 45:3
subclasses [1] 327:22 12 308:4 suspect [2] 318:15 335:18 tease [1] 273:11
Subcommittee [2] 45:10,14 sulfonamide [1] 28:5 sustained [8] 226:4,14 227: technical [3] 56:22 121:1
subcutaneous [1] 59:11 Sulpicio [2] 2:10 3:26 10,12,14 228:8,10 340:17 132:18
subcutaneously [2] 42:18 summarize [7] 41:12 175:15 sustained-release [1] 228: technically [2] 66:9 121:8
64:18 176:16 177:13 183:16 199: 13 technique [5] 167:5 184:12
subgroup [1] 195:14 14 356:11 swallowed [1] 222:21 185:3 309:22,22
subject [2] 17:16 98:19 summarized [1] 318:5 Sweden [1] 61:7 techniques [5] 247:11 249:5
subjected [3] 91:9 186:2 262: summarizes [1] 59:21 swelling [1] 174:9 265:20 362:21 364:6
9 summary [8] 175:8 238:12 swim [1] 126:13 technologies [1] 255:9
subjects [1] 29:16 248:11 259:4 322:10 363:13, swimmers [1] 126:7 technology [2] 244:1 361:13
subMAC [1] 190:15 22 365:1 switched [1] 186:7 temperature [3] 137:12 292:
submerged [3] 126:15 127:1, Sunny [4] 184:19 308:17,18 switchover [1] 314:5 1,7
14 356:21 symmetrical [1] 80:14 temporal [1] 96:3
submissions [1] 37:19 superficial [2] 87:8 96:10 synapses [5] 111:4,10 112: temporally [1] 37:11
submit [6] 37:2,3,5 69:14 187: superiority [3] 227:19 228:7, 14 113:14 116:8 temporarily [1] 222:17
9,18 11 synaptic [1] 55:13 TEMPORARY [1] 2:16
submitted [2] 9:11 243:5 supermaximal [1] 336:7 synaptogenesis [32] 12:10 tend [4] 18:12 37:16,17 276:
subplate [1] 102:6 supervisor [1] 5:19 16:22 17:11 19:16 20:13 49: 11
subpopulation [1] 225:20 supervisory [2] 14:4 45:12 1 76:3 85:12 92:18 93:1,5 tends [3] 37:11 137:21 262:5
subpopulations [1] 347:19 SUPPORT [20] 1:4 2:4,12 5:4 103:3 110:15 111:2 112:6,10 tensor [1] 360:18
subsequent [6] 45:8 105:10 9:9 29:1 46:15 47:3 57:10 113:1,5,12 114:6 122:14 123: tentative [1] 96:20
245:22 256:20 257:6 289:21 162:9 174:2 182:9 184:9 270: 6 131:22 133:15 139:2 146:1 teratogenic [1] 24:18
subsequently [1] 241:12 13 283:19 284:13 310:17,21 191:20 192:1,8 200:3 270:1, term [8] 93:22 164:13 166:10
subsets [1] 293:13 330:22 336:10 3 175:18 179:11 300:22 342:
substance [1] 107:17 supported [2] 31:13 256:11 synaptogenic [1] 18:5 19 360:16
substances [2] 17:17 28:14 supporting [1] 64:7 syndrome [10] 71:3,13 77:8 termed [1] 18:8
substantial [5] 20:1 204:4 supports [2] 12:21 177:7 103:19 104:4 105:1,20,20 terms [19] 37:22 38:9 50:21
248:18 267:21 346:21 supposed [2] 287:22 345:12 194:19 208:20 51:14 58:17 68:6 114:3 174:
substantially [1] 222:10 Supreme [1] 30:10 syndromes [2] 195:19 197:1 15 244:13 247:20 263:22
subtle [10] 11:20 34:6 37:17 surface [5] 57:18 98:3 336:6, Synergistic [3] 242:16 327: 275:13 288:19 290:2 292:2
62:4 78:14 154:7 276:12,21 11 337:7 14 335:11 322:11 335:11 341:21 359:6
290:21 323:7 surfaces [1] 336:2 synonymous [1] 76:2 Terri [2] 247:17 248:6
subtoxic [1] 70:7 surgeons [1] 108:11 synthesis [1] 161:4 terrified [1] 301:17
subtype [1] 116:19 surgeries [5] 108:8 109:3 synthetic [1] 323:1 test [9] 89:1 107:16 128:13
subunit [10] 148:19,20 154: 195:15,16 197:13 System [25] 36:21 38:3 76:13 158:22 236:7 257:8 285:17
15,15 155:2 161:4 174:19 surgery [61] 20:19 21:5 22:10 110:10,11 116:17,18 124:22 348:20 358:21
178:2,4 338:7 36:9 60:5,21 73:7 101:2 184: 147:14 148:8,10 149:5 153: test-tube [1] 239:11
successful [1] 137:4 7,13 185:1 186:6,11 190:4,7, 16 156:21 161:13 162:22 tested [6] 67:1 93:3,3 242:22
successfully [1] 75:2 8,14 192:15,16 193:10,19 167:4 172:16 173:8 219:15 258:9 280:13
succumb [3] 92:16,20,22 194:9 195:11,20 196:12 197: 220:22 240:8,9 267:9 270:5 testing [8] 54:16 127:18,18
sudden [1] 242:2 3,3,9 201:20,21 207:16 234: Systems [10] 4:12 39:2 46:1, 243:5,8 282:5 285:14 348:14
suffering [4] 201:18 225:15 12 235:19,21 246:16 247:2, 2 76:10,12 138:11 243:22 tests [6] 211:8 264:18 285:15
308:10,14 15 251:9,12 254:5,10 261:17 262:22 297:2 291:3 352:13 354:14
sufficient [10] 36:15 85:13 262:6,10 264:11,20 286:21 tetracaine [2] 282:3,3
104:1 132:17 310:10 312:17, 287:6,7 307:18,19,21 316:9,
T Texas [1] 8:12
15,19 334:6 344:5 363:8 364: table 5:6 18:22 22:17 23:
[14]
19,22 313:5,11 textbook [1] 114:21
suggest [7] 21:4 35:20 63:7 16,19,21 9 59:21 143:4 169:16 306:18 thalamic [4] 81:16 123:3,19
67:13 203:14 276:9 331:14 surgical [28] 21:2,21 36:10 322:10 325:12 328:8 345:13 132:12
suggested [7] 54:21 144:8 68:19,22 95:4 100:21 144:2 361:17 365:2 thalamus [12] 123:1 129:22
165:4 166:13 190:12 193:11 tables 27:8
[1]
206:4 235:20 279:19 298:21 130:16 131:10 132:3 138:17
330:4 196:8 206:20 247:16 261:22 tag [1] 270:19
150:6 267:10,19 276:8 299:
265:6 302:19 317:18 330:18 tail 168:10 305:16
[2]
suggesting [11] 20:11 62:2 18 300:1
179:20 233:1 255:1 259:1 332:7 333:22 343:15 355:9, tailor [1] 336:7
thalidomide [2] 28:17 241:
261:7 277:15 294:19 325:9 11,16 361:17 364:4 talked [11] 173:21 180:5 232: 19
330:7 surgically [1] 343:17 8 274:1 318:7,17 321:22 331: Thanks [3] 70:22 74:5 249:14
suggestion 337:6 350:20 surprise 321:8
[2] [1] 8 359:17 362:19 364:6 themselves [5] 10:8 34:9
suggestions [4] 225:3 229:3 surprising [1] 358:3 tally [1] 263:9 143:5 336:7 349:21
243:7 277:7 surprisingly [1] 39:2 tampering [1] 116:3 theoretical [1] 20:8
suggests 17:17 53:22 60: surrogate 270:11,14
[8] [2] tank [1] 126:12 theories [1] 240:1
22 161:2 242:12 245:4 259: Surveillance [1] 38:13 target [2] 152:21 153:8 Theory [5] 240:5,5 242:6 255:
17 274:16 survival [1] 109:2 targets [1] 62:3 21 346:22
suicide 74:20 75:3 113:17, survive 195:17
[6] [1] task [7] 126:20 127:11,21 162: therapeutic [5] 97:1 223:15
19 114:1 115:15 survived [1] 75:8 13 211:12,17 212:11 227:8 339:16 353:3
suitable [3] 34:21 35:7 277: susceptibility [4] 12:8 191: tasks [6] 126:3,5 165:16 212:
therapies [5] 20:15 319:18
16 14 192:18 193:4 5 290:14 348:21 327:19 329:15,17
suites [1] 108:10 susceptible [4] 63:9 130:5 taste [2] 62:18 63:1 therapy [6] 27:3 40:11 125:2
taught [1] 63:1
therapy - two

279:4 291:16 329:19 2 341:8 364:17 totally [2] 142:14 143:12 trials [7] 30:22 31:5 33:7,14
thereby [2] 17:12 24:1 Tinker's [1] 247:5 touch [1] 245:6 127:2 255:4 362:21
therefore [13] 184:4 189:7 TIP [1] 343:14 touched [1] 339:2 triangles [1] 168:15
193:2 236:2 237:4 238:16 tissue [9] 21:9 100:13,14 153: toward [1] 270:17 tried [1] 286:2
239:7 266:8 291:5 307:16 8 223:6 240:11,16 241:10 towards [2] 39:3 309:21 trigger [10] 18:4 75:13 76:11,
308:19 331:4,5 303:17 town [1] 225:11 15 85:13 86:12 97:19 98:21
thinking [13] 121:13 183:18 tissues [2] 43:18 241:6 Tox [1] 161:10 299:1 359:19
186:7 201:15 276:6 281:5 title [1] 65:19 toxic [13] 193:18 209:15 213:triggered [1] 77:3
293:7 297:7 307:2 321:11 titled [1] 33:11 16 221:3 231:15 239:4 242:5,triggering [1] 107:1
327:17 351:13 359:20 titrated [2] 215:13,13 18 263:5 265:16 295:8 320: triggers [2] 86:15 91:13
thiopental [1] 23:4 TIVA [7] 252:11 253:19 254: 16 335:17 trimester [9] 17:7 24:22 49:5
third [8] 17:7 25:8 49:5 60:17 19 255:2,7,13,21 toxicities [6] 34:22 35:8 56: 69:4 94:2 110:16 111:20 269:
69:4 90:15 92:14 94:2 tocolysis [2] 350:15 353:20 15 193:21 337:5 343:4 18 351:18
Thomas [1] 2:8 today [59] 11:3 13:8 15:4,9 16: toxicity [17] 13:3 52:2 56:16trimesters [2] 25:2,8
thoracic [1] 273:18 12 41:11 42:2,6 43:3 50:19 70:3,7,8 154:18 155:19 178: triple [12] 88:11,22 118:17
thoraco-amniotic [1] 21:9 52:13,20 53:6 61:8 67:6,8,9 6 195:7 231:22 240:3 242:13 121:17 122:8 123:7,15 124:2
thorough [1] 281:15 74:6 110:9,13 111:4 112:3,7 263:11,13,18 334:19 138:21 140:1 209:13 268:10
thoroughly [1] 277:14 113:6,16 117:6 126:2 135:2 Toxicological [16] 5:16 12:3, triples [1] 110:19
though [12] 104:11 124:18,19 140:20 146:13 209:2 213:21 13 30:6 44:22 48:2 56:9,18 tripling [1] 111:9
199:9 216:3 263:17 265:11 220:2,8 222:2 224:21 230:1, 57:3 58:18 65:17 147:16 149: trophic [1] 17:19
304:21 323:14 332:12 338: 7 244:4 248:16 250:6,15 251: 18 157:3 167:22 175:9 troubling [1] 250:11
20 346:21 21 255:1 261:2 263:19 274:9 Toxicology [5] 45:10 47:3,5, true [9] 21:17 38:3 55:21,22
thought-provoking [1] 363: 275:1 276:7 282:11 283:3 12 56:5 202:2 221:10 227:21 282:8
4 288:19 308:22 321:1 323:19 traces [2] 82:2,4 323:2
thoughthe [1] 188:4 324:12 330:20 359:19 365: trachea [1] 190:10 truly [4] 288:3 302:6 305:1
thoughts [5] 14:17 45:15 266: 10 track [1] 358:22 364:21
16 330:1 362:3 Today's [4] 13:5 16:13 49:18 tract [1] 21:8 try [40] 43:11 45:3,16 47:6,13,
thousand [1] 251:13 50:3 trade [1] 260:19 16 48:9 50:2 55:5,18 56:8 57:
thousands [3] 28:19 264:5 Todorovic [27] 6:14 11:9 13: tragedy [4] 221:8,21 224:7 3,13 58:2 59:2,18 72:16 97:
314:6 9 14:10 54:5 63:14 90:4 107: 225:15 21 149:12 165:5 176:11 179:
threat [2] 223:18 318:15 20 146:22 187:7,17 189:17 tragic [2] 221:7 228:16 6 209:21 215:21 255:20 270:
three [20] 49:7 68:15 69:4 76: 192:4,12 198:7 202:11 203:8 training [2] 126:13 223:11 22 271:2 283:11 284:2 287:3,
5 78:4 81:20 96:4 141:5 164: 208:1,7 256:18 258:13 266: transcardiac [1] 120:15 15 297:6 307:9 309:21 320:
11,17 171:3 175:14 182:20 21 267:6 287:18 294:14 320: transgene [1] 232:18 10 328:17 337:20 339:13
244:6 245:7 323:18 332:11 16 322:5 transgenic [4] 232:3,14 233: 343:8 347:7
337:12 338:22 339:6 Todorovic's [2] 187:2 353: 7,20 trying [20] 44:8 58:8,17 67:21
three--and [1] 141:5 17 transgenics [1] 232:20 68:6 102:14 104:12 112:4
three-dimensional [1] 241: together [14] 122:16 149:20 transitional [1] 196:5 162:8,12 165:3,22 179:4 216:
10 161:8 173:20 182:11 185:17 translate [1] 315:3 1 270:18 289:15 293:12 341:
threshold [6] 60:22 64:8 85: 199:1 203:13 213:11 238:4 translated [1] 180:19 7,19 354:15
2,8 179:1,1 239:3,3 240:9 243:4 translational [1] 271:1 tsunami [1] 226:16
thrombin [12] 240:10,13,15, tolerance [4] 331:18,19 332: translocate [1] 79:17 tub [1] 303:16
17 241:8,12,20,20,22 242:2,4, 2,5 translocated [1] 98:10 tube [2] 236:7 252:9
10 tolerances [1] 28:13 translocation [1] 98:6 tune [1] 104:12
throughout [8] 79:1 94:19 tolerate [1] 287:7 transmission [1] 193:16 TUNEL [6] 77:22 124:15 156:
135:18 165:6 190:4 292:8 tolerated [1] 203:22 transmitter [1] 76:10 1 160:9,9,22
325:16 352:4 Tom [2] 6:7 350:3 transparency [1] 218:10 turn [13] 76:19 79:20 246:10
throw [3] 133:6 203:1 250:20 Tom's [1] 350:19 transparent [1] 218:8 252:1 254:10 265:8 266:19
thumb [1] 314:16 tonsil [1] 286:12 transposition [1] 197:13 317:9,11 333:9 334:9 341:2
Thursday [1] 1:6 tonsillectomies [1] 142:19 trauma [1] 249:17 342:22
tickets [1] 250:4 tonsillectomy [1] 141:8 travel [1] 218:21 turning [2] 254:3,11
tidal [1] 253:18 took [14] 127:10 129:21 131:1 traveling [1] 143:19 turns [3] 107:16 272:9 300:1
tie [1] 175:3 134:21 145:1 189:21 190:2 treat [3] 21:1 161:15 225:19 Twelve [1] 81:18
ties [1] 250:5 211:13 226:17 229:1 268:12 treated [11] 35:18 43:6,8 62: twice [5] 127:10 138:13 211:
tight [1] 57:9 284:8 308:15,17 11,16,21 63:3 169:9 171:19 13,16 212:12
tightly [6] 114:11,12 137:9,11 tool [2] 180:7 205:15 257:14 343:17 Twin [2] 316:12,15
139:4 170:8 tools [11] 104:10 205:10 290: treating [1] 21:6 twins [2] 316:13,18
time-concentration [1] 100: 10 291:6,9 356:21 357:5,6,12 treatment [17] 15:20 21:7,10 two [47] 23:1 25:18 30:4 49:
8 363:1,2 54:17 65:4 80:11 81:21 154: 10 56:7 68:15,17 70:1,2,8 72:
time-consuming [1] 30:14 top [3] 121:12 133:11 134:18 14 174:22 226:1 235:9 257: 18 76:17 96:16 100:22 106:9
time-course [6] 157:19 159: topic [7] 16:13 36:7 40:16 74: 16 258:4 259:7 271:13 308: 111:2,21 115:22 116:4 117:
2 173:4 177:1 319:11 328:10 11 261:4 264:2 343:1 20 343:16 20 126:3 127:8 128:22 130:
timeline [4] 10:18 112:8 192: topical [1] 34:20 tremendous [1] 150:8 15 155:7 157:22 204:6,7 220:
7 303:4 topics [1] 250:2 trial [19] 44:14 128:3 199:10 10 237:21,22 238:3 244:13
timelines [1] 112:2 toppled [3] 98:8,9,16 258:15,16 272:15 273:1,8 245:1 251:11 269:6 270:7
timely [2] 97:7 361:20 total [7] 44:4 59:13 70:5 93: 343:21 344:18 345:1,6 347:1, 278:2 279:17 301:9 332:7
Timing [5] 37:10 290:16 305: 22 227:2 251:7 256:2 10,11 351:4 360:5 362:18,18 337:12,19 339:7,9 347:2 364:
two - Wake

11 22 12 85:4 86:22 88:11 91:12 versa [1] 122:18
type [24] 18:4,7 36:12,22 37: uniformly [1] 351:9 100:3 116:16 121:17 133:19 versus [24] 21:5 133:18 156:
10 38:1 68:21 80:17 107:17 unique [3] 18:4 34:2 240:14 137:8 140:1 152:6 153:17 18 171:19 174:16 186:2 200:
120:2 152:7 174:8 233:4,18, unit [3] 197:4 203:19 291:15 154:3,4 155:16 156:11,19,21 22 223:15 227:12,22 262:3
21 240:14 269:21 279:12 United [4] 27:19 235:4 325: 157:19,21 159:7 164:20 166: 273:3,12 282:2,20 283:6 296:
290:7 294:10 297:11 335:10 16 351:15 1 167:2 173:1 180:4,16 186: 13 309:22 321:12 323:6 341:
345:1,6 units [3] 135:17 212:21 213:3 8 205:15 207:17 213:11 239: 10 343:15 347:6 360:14
types [8] 14:22 59:19 78:2 University [17] 4:7,16 6:6,9, 16 250:17 251:15 252:18 Vesna [23] 2:19 3:19 6:14 74:
148:20 158:1 196:20 241:11 11,15 7:3,7,9 8:8,12 228:5 254:19 255:1,20 264:17 281: 14 84:20 88:20 90:3 150:2
330:19 247:18 248:7 257:3 275:3 3 283:14 289:12 290:12 291: 155:5 162:11,16 167:9 172:2
typical [4] 114:22 123:14 124: 303:12 2,5 295:18 296:17 304:17 173:21 179:19 180:4 181:1
12 189:13 unknown [2] 40:6 202:4 319:19,21,22 320:4,18,20 232:7 262:16 263:21 266:3
Typically [5] 33:2 39:4 188:8, unless [1] 336:19 322:19 342:19 344:4 348:10 292:6 356:22
14 206:5 unlike [2] 18:13 19:19 354:16 Vesna's [3] 88:11 181:20,22
unlikely [4] 146:2 246:3 327: utero [5] 20:6 63:4 296:16 vessicoamniotic [1] 21:7
U 1 338:20 351:14 363:8 veteran [1] 247:11
U.C [1] 228:22 unnoticed [1] 44:17 uterus [1] 353:21 via [4] 18:2 240:13 241:8 242:
U.S [4] 28:22 30:10 220:7 344: unrecognized [1] 109:20 utilize [1] 68:7 18
1 unrelieved [3] 316:5 317:8, utilized [10] 35:2,10 42:8 53: viability [1] 236:9
UK [1] 344:1 21 8,13 54:10,13 57:8 59:9 67: viable [3] 35:13 108:15,20
ultimately [11] 44:18 47:1,11, unstimulated [1] 194:7 15 vice [1] 122:18
21 58:7,16 68:1,4 129:17 unsuccessful [1] 74:21 utilizes [1] 240:15 vicious [4] 236:18 238:10,20
131:15 297:17 until [11] 22:10 76:12 98:10 utilizing [2] 42:17 43:10 239:9
un-studyable [1] 363:15 152:16 201:5,8 212:7 222:17 view [7] 60:6 81:12 204:7 294:
unable [5] 47:21 145:6 276:2 275:22 287:10 299:20 V 1 316:6 333:14 365:4
317:9,11 untoward [1] 21:2 vacuolization [1] 50:15
Virginia [5] 4:6 6:15,16 8:3
unavoidable [1] 28:14 unusual [1] 147:7 valid [3] 90:1,16 91:15 225:12
uncle [1] 220:19 unwanted [1] 140:22 validated [1] 290:11 virtual [1] 226:16
unclear [2] 51:9 242:22 up [88] 34:9 54:16 74:16 87: validative [1] 291:9 virtually [3] 19:13 152:6 334:
uncomfortable [2] 303:15 11,15 114:8 118:7 119:4 121: valproic 194:22
[1]
14
325:9 5,18 122:21 125:17 135:10 value [1] 73:8 vis-a-vis [1] 112:7
uncontrolled [1] 193:13 141:4 142:1 143:14 144:18 values [8] 92:7 136:20 159:8 visible [1] 126:14
uncover [1] 290:21 152:9 154:6,9,20 155:12,14 168:14 170:2,5,18 216:18 visual [3] 276:8,13 349:9
uncovered [1] 195:20 157:5 163:4,7,19 168:4 170: Van 4:5 224:18,19,19
[4]
vital [4] 121:2 134:19 137:9
under [22] 18:7 23:19 32:9,14 5,8,11,15 172:19 174:15 181: Vanderbilt [1] 7:6 224:3
81:19 90:11 94:7 100:7 142: 12 191:5 202:15 203:15 204: vapor
[11] 251:15 253:7,10
vitality [1] 242:1
17 144:3 191:10 203:19 247: 15 205:6,20 208:3,18 211:20 254:3,7,11,19 255:13,20 284: vitro [9] 19:3 153:16 156:19
7 291:19 292:3,17 293:8 294: 215:13,13 225:2 231:10 236: 20 352:3 175:4 177:16 205:4,5 239:10
10 304:3 319:11 340:9 349: 2 250:20 252:4,7 263:8,9 vaporizers [3] 213:2 251:10 288:5
19 269:13 274:22 275:12,20 252:1 vivo [15] 41:15 52:8 65:14
underestimates [1] 38:6 276:10,16,22 277:19,20 284: vapors 252:6
[1]
158:8 159:10 166:7 175:3
undergo [3] 269:3,7 364:21 17 286:20 289:1 298:15 300: variability [1] 351:11
176:13 177:16 204:12 205:6
undergoing [11] 15:16 43:13 12 308:4 315:2,3 316:8 319: variable [1] 292:9 239:12 262:21 263:13 288:4
77:15 87:10 184:22 192:15, 5 321:1,10 323:8,17 324:7 variables [7] 196:21 199:11 volatile [4] 244:22 245:19
16 194:9 196:12 208:9 346:4 325:20 328:2 332:2 335:3 287:4 288:1 292:18 344:3,13 246:15,16
undergone [5] 145:9 196:14 336:4 347:9 353:2,16 357:16 variation 114:10 190:22
[4]
volume [1] 295:19
197:12 316:19 317:7 362:18 294:6,7 volumetric [2] 274:13 275:6
understand [42] 13:22 14:19 upheld [1] 30:10 variations [2] 105:21 122:3 voluntary [2] 37:1 38:2
15:17 44:8 45:4,17 47:16 55: upregated [1] 314:8 varied [1] 166:20 vomiting [1] 251:22
18 56:3 58:8,17 59:3,19 68:6 upregulated [2] 299:20 314: varies [1] 190:7 vote [5] 310:13,20 311:2,10
69:7,9 103:8 149:12 151:8 6 variety [9] 182:9 205:12,12 332:17
165:22 176:13 179:4 181:4 upregulating [1] 360:10 262:19 281:6,7 290:11 351:7 votes [1] 310:20
191:10 204:7 205:17 206:17 upregulation [12] 154:17 357:1 Voting [8] 2:5,16 6:22 7:1
207:1 211:1 218:12 288:12 155:1,18 161:4,5,21 162:4 various [16] 47:8 56:2 64:17
311:4,8 315:9,13
293:7,9,12 294:11 308:18 175:2,5 176:18 178:1,5 152:4 153:22 191:20 199:4, vulnerability [14] 48:10,17
313:8 318:9 319:10 342:6 upregulator [1] 177:3 21 201:10 205:10 207:4 241: 49:2,16 75:21 122:9 123:4
357:12 362:5 urge 261:11
[1] 11 254:1,15 341:16 349:1 192:18 313:7 314:11 341:9
understanding [10] 13:12 44: urgent [2] 36:11 307:18 vast [2] 229:12,13 344:15 357:18,19
10 46:19 47:7 53:2 58:5 68: urinary [1] 21:7 vehicle [1] 61:14 vulnerable [11] 17:10 20:9
20 72:13 267:2 329:6 usage [1] 265:18 ventilate [1] 134:15 22:11 39:21 130:16 132:1
understood [1] 364:15 useful [12] 14:18 15:1 289:15 ventilated 189:12
[1]
140:8 145:21 260:13 331:12
underway [1] 57:12 293:11,20 337:7,16 338:12 ventilation [3] 272:5 273:13, 362:11
underwent [2] 144:11 317:4 350:19 357:13,14 362:1 18
undesirable [2] 229:17,19 user [1] 228:21 ventilators [1] 190:1 W
unfortunately [4] 61:8 97:5 users [1] 226:17 ventilatory [1] 185:7 wait [4] 20:21 160:20 277:9
209:16 307:5 using [68] 19:9 34:16 61:11 ventral [1] 278:10 305:11
Unified [1] 240:5 70:7 75:17 77:20 79:10 80:5, ventricle 120:15
[1] waiting [1] 180:10
uniform [3] 100:9 347:14 362: verify [1] 256:4 Wake [3] 6:11 252:4,7
wake-up - Zuppa

wake-up [1] 251:12 whether [40] 30:20 51:9 52:8 wine [1] 103:21 xenon [12] 117:11 294:14,15,
walk [3] 133:6 226:12 297:7 76:9 106:17 109:6 125:8 146: wish [3] 10:13 170:22 277:13 19,21 295:1,4 296:6 297:1
walks [2] 37:2 358:18 15 163:13 164:22 199:22 wishing [1] 334:8 319:1 320:9 328:22
Walnut [1] 249:16 200:1 205:7 209:14,18 215:3, wit [1] 29:2 Xie [3] 4:9 234:17,18
wander [1] 137:3 14 231:21,21 261:20 266:3, withdrawal [6] 66:4 152:6,9
Wang [2] 157:2 182:6 11 273:11 277:7 291:20 292: 153:8 159:16 166:16
Y
wanted [19] 74:18 118:6 119: 22 297:1 309:13 310:9 312: withdrew [1] 159:17 Yale [2] 8:1 275:3
11 136:6 139:19 148:15 151: 16 314:9 315:11 321:14 327: withhold [1] 147:2 yank [1] 252:9
7 156:13 158:8 164:5,18,22 21 343:8 352:6,8,10 360:7,8 within [20] 23:22 43:18 46:12 year [12] 29:3 30:3 33:10 38:
165:9 188:6 209:13 270:21 white [8] 19:1 23:14,20 272: 48:17 66:14 89:12 92:17 136: 15 110:18 235:9,19 241:17
271:7 337:13 357:16 20 273:6,22 274:14,17 21 149:14 153:15 162:6 167: 249:20 314:4 316:15 351:17
warm [1] 284:12 white-matter [1] 274:13 14,15 199:8 326:10,15,17 years [76] 17:7 21:20 22:22
warrant [1] 265:17 whole [22] 39:19 110:10 119: 332:7 339:8,9 23:19 28:1,2,15 30:4 32:20
Washington [2] 8:4 303:12 14 125:15,22 138:20 145:2 without [16] 115:17 125:8 34:5,9 38:18 39:3 49:7,21 52:
washout [5] 157:20 159:20 183:11 189:4 193:7,20 194:1 161:5 169:14 193:8 221:13 12 68:11 69:5 75:1 76:7 83:
160:4 171:12,13 222:21 226:3,21 230:19 285: 237:10 251:14 252:15 253:5 16,17 85:7 105:2 108:5,9,15
water [14] 84:9,10 102:1 126: 8 296:6 297:9 331:21 339:1 254:6 257:10 277:9 287:7 111:21 142:1,9 143:14 144:
3,8,9,12 127:5 198:8 203:2 346:5 325:6 345:2 20 148:1 161:10 162:14 163:
232:7 258:10,12 357:15 whom [4] 28:7 261:15,19 264: Wlody [8] 2:11 7:8,8 69:17 7 165:15 167:7 182:8 184:1
way [51] 38:7 85:6 98:17 102: 16 312:5 313:17 320:22 335:2 197:22,22 200:2,2,2,3 201:3
13 112:4 113:16 114:10 116: wide [2] 183:8 243:1 woman [1] 27:1 212:7 220:13 225:11,13,22
13 120:13,14 128:12 133:10, widely [2] 222:12 254:20 women [12] 24:20 25:6,22 26: 227:4 234:5 246:2 247:2,5
11 139:22 141:17 146:14 widespread [6] 43:18 50:20 12 31:4 278:17 350:5,14 352: 264:6 275:5,9 276:11,17,19
159:2 165:6 167:2 169:8,9 55:11 85:13 118:21 299:1 16,20 353:13 363:6 277:1,10 291:1 296:17 301:2,
176:12 187:13 198:9 207:2 widest [1] 97:14 Women's [1] 4:19 3 303:2 308:16 316:17 323:5
220:5 232:19,19 243:21 265: wife [2] 220:8 221:21 wonder [5] 69:22 70:4,6 315: 345:21 358:15 359:16
21 285:21 286:22 290:1 299: wild [3] 233:4,18,21 14 352:6 yellow [1] 219:12
8 302:16 304:22 321:10 325: wild-type [2] 232:15 233:6 wondered [1] 103:19 York [1] 7:10
22 328:13 332:16 335:4 339: will [159] 5:13,16 6:20 10:9,15, wonderful [3] 101:6 224:15 young [17] 35:15 109:3 110:3
17 341:7 344:6,17 347:22 17,19 13:5,15,21,22 14:5,11, 326:3 124:22 125:1 146:20 153:20
358:16 359:21 360:2 361:5,6 14,22 16:3,16 22:12 34:8 36: wondering [2] 214:14 291:18 164:15 221:17 226:8 228:19
Wayne [2] 2:23 8:10 6,7 40:12,16 41:5 42:1 43:1 words [1] 309:20 244:15 263:9,12,14,15 277:3
ways [13] 67:21 153:14 155: 48:3,4,5 50:11 51:3,7 52:14 work [44] 35:12 48:15 115:20 younger [4] 141:22 143:13
21 156:8 180:11 181:3,5 250: 54:7 58:6 61:8 63:13 67:6,8, 119:14 120:21 134:1,9 145: 144:19 264:12
18 287:15 299:21 327:2 339: 9,18,19 69:11 71:5,5 74:2,3, 15 147:22 149:8,8,18 150:12 yourself [1] 306:20
13 351:9 11,14 78:1 82:16 83:7 84:6, 155:5 157:1,16 162:13 170:1 yourselves [1] 5:7
weakness [1] 263:20 20 85:9,16 89:17 93:10 97: 171:5 173:20 175:4 181:14, Z
Wechsler [2] 345:21 348:11 21 99:15,17,18 103:1,2,4,7 20 182:5 185:22 193:12 202:
ZARS [2] 8:2110:2
week [3] 17:5 112:17 220:11 107:21 109:7 112:6 113:5,18 10 209:4 210:17,18 229:10,
Zee [4] 4:5 224:18,19,19
weeks [16] 48:18 76:5 92:21 119:6,17 120:17 135:3 140: 13 231:19 232:2 253:20 270:
Zelterman [6] 2:24 7:22,22
108:18,20 112:12 133:16 20 146:13 147:1,8,9,12,13 20 271:6 281:7 287:13,20
312:2 313:14 362:7
189:22 262:12 269:8 271:14, 156:8 165:21 166:4 167:18, 293:16 298:10 314:18 326:3
zero [8] 91:19 120:5 127:4
22 272:11 332:1,7 353:15 19 168:1,3 169:16 180:7,10 worked [1] 363:4 130:2,19 152:1,17 153:5
Wei [5] 4:16 256:8,9 269:13 181:5 182:18,20 183:1 195: Working [11] 44:19 84:22 zeroed [2] 140:8 211:4
296:15 17 196:12 197:9 201:6 206: 104:12 149:19 161:9 162:7
Zhong [1] 4:9
weighs [1] 167:12 22 214:8,9 216:22 219:8,10, 182:7,11 288:9 309:8 361:15
zone [1] 102:6
weight [3] 101:22 110:17 359: 17,20,21 221:17 222:2 223: workload-reducing [1] 255: Zorumski [1] 268:7
7 19 233:16 234:17 235:5,8 7
Zuppa [26] 2:25 7:18,19 99:
weighted [1] 39:3 237:14 238:15,19 243:16 works [2] 298:9,9 22 100:1,16 214:10 215:10
weights [1] 285:9 245:6 250:2 254:6,16 257:4 world [6] 57:5 86:9 235:4 286: 268:8 270:7 271:5 273:15
weird [1] 252:4 259:21,22 260:3,6,10 266:19 6 326:15,17
288:22 291:13 293:22 307:5
Welcome [4] 11:1 16:10 41:9 269:7 273:5 275:12 276:1 worldwide [1] 235:18 312:3 313:15 319:13 323:10
243:6 278:21 282:7 287:2 291:7,10 wormlike [1] 79:1 329:15 331:7 335:7 342:9
well-controlled [4] 24:20 25: 298:3,4 301:19 311:10,17 worrisome [2] 244:9 313:3 346:18 347:12
21 26:5 29:9 314:20 315:17 319:22 320: worry [1] 253:13
well-designed [2] 13:1 146: 19 326:7 327:17 330:12 333: worse [2] 127:16 138:20
18 3,16 334:9 338:15 339:15 worst [3] 60:6 73:1 286:22
well-known [1] 117:6 344:6 345:11 worth [3] 20:2 23:1 54:10
well-understood [1] 364:13 William [4] 2:31 3:23 48:3 worthwhile [1] 293:1
western [2] 28:20 79:11 147:13 worthy [1] 333:1
whatever [4] 134:13 225:19 willing [1] 303:5 Wozniak [3] 125:14 209:5
265:18 283:22 willingness [1] 15:21 210:17
whatsoever [2] 57:17 297:21 wind [1] 276:16 WPSSI [1] 346:1
whereas [7] 50:5 63:2 92:20 window [9] 48:10,16 75:20 Wright [1] 227:16
101:16 127:7 191:4 353:1 163:13 176:10 178:14 205:5 written [1] 218:16
whereby [1] 79:16 275:17 315:7 wrote [2] 249:2 358:15
Whereupon [2] 217:2 365:21 windows [1] 317:22
X