Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

1.

The Opioid Class of Analgesics

2.

Legal Terms and Conditions

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 1

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

3.

Opioid Class of Analgesics: Slide 3

4.

Legal Terms and Conditions (cont’d.)

OCW: Introduction to Clinical Pain Problems (J. Haddox)

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Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

5.

Program Objectives

6.

Definitions

OCW: Introduction to Clinical Pain Problems (J. Haddox)

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Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

7.

Opioids

8.

Opioids & Receptor Activity

OCW: Introduction to Clinical Pain Problems (J. Haddox)

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Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

9.

Mu (µ) Receptor Activation

10.

Dose-response Curves

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 5

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

11.

How does this correlate to clinical pain management?

12.

Opioid Agonists: Structural Pharmacology

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 6

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

13.

Opioid Rotation (OR)

14.

Codeine

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 7

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

15.

Codeine

16.

Morphine

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 8

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

17.

Morphine

18.

M-3-G (morphine-3-glucuronide)

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 9

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

19.

M-6-G (morphine-6-glucuronide)

20.

M-6-G and M-3-G (continued)

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 10

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

21.

Renal Dysfunction and Morphine

22.

Hepatic Dysfunction and Morphine

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 11

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

23.

Pruritus and Morphine

24.

Oxycodone

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 12

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

25.

Oxycodone

26.

Oxycodone

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 13

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

27.

Hydrocodone

28.

Hydromorphone (HM)

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 14

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

29.

Biotransformation of HM

30.

Metabolite Profile of Hydromorphone

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 15

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

31.

Potential Role of HM Metabolites

32.

Methadone

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 16

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

33.

Methadone

34.

Methadone

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 17

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

35.

Propoxyphene

36.

Meperidine

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 18

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

37.

Normeperidine

38.

Fentanyl

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 19

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

39.

Levorphanol and Congeners

40.

Buprenorphine

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 20

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

41.

Agonist-antagonists

42.

Opioid Antagonists

OCW: Introduction to Clinical Pain Problems (J. Haddox)

Page - 21

Tufts OpenCourseWare Opioid Class of Analgesics

© 2007 Tufts University

43.

Summary

OCW: Introduction to Clinical Pain Problems (J. Haddox)

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