2012

Dialysis of Drugs

George R. Bailie, PharmD, PhD Albany College of Pharmacy and Health Sciences Nancy A. Mason, PharmD University of Michigan College of Pharmacy Renal Pharmacy Consultants, LLC Saline, Michigan USA

2012 Dialysis of Drugs

DISCLAIMER—These Dialysis of Drugs guidelines are offered as a general summary of information for pharmacists and other medical professionals. Inappropriate administration of drugs may involve serious medical risks to the patient that can only be identified by medical professionals. Depending on the circumstances, the risks can be serious and can include severe injury, including death. These guidelines cannot identify medical risks specific to an individual patient or recommend patient treatment. These guidelines are not to be used as a substitute for professional training. The absence of typographical errors is not guaranteed. Use of these guidelines indicates acknowledgment that neither Renal Pharmacy Consultants, LLC., nor Sanofi will be responsible for any loss or injury, including death, sustained in connection with or as a result of the use of these guidelines. Readers should consult the approved Product Information for each agent indicated before prescribing medications. Guides such as this one can only draw from information available as of the date of publication. Neither Renal Pharmacy Consultants, LLC. nor Sanofi is under any obligation to update information contained herein. Future medical advances or product information may affect or change the information provided. Pharmacists and other medical professionals using these guidelines are responsible for monitoring ongoing medical advances relating to dialysis. Copyright © 2012 Renal Pharmacy Consultants, LLC. All rights reserved. This material may not be published, rewritten or redistributed.

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I PREFACE

Preface
Drug removal during dialysis is of interest to those caring for patients receiving hemodialysis or peritoneal dialysis. The extent of drug dialyzability determines whether supplemental dosing is necessary during or following dialysis. The accompanying table is a reference regarding the effect of dialysis on drug clearance. This table should be used as a general guideline. The drugs included in the table are parent drugs. In some cases, these drugs are converted to pharmacologically active or toxic metabolites for which little dialysis information is known. Therefore, for a few drugs, a primary metabolite is also included in the table. When available, serum drug measurements may be appropriate for dosing individual patients. In all cases, patients should be monitored for clinical efficacy and toxicity. There are many potential influences on drug dialyzability. The reader is referred to www. renalpharmacyconsultants.com for detailed information about: • Factors that determine drug dialyzability, including molecular weight, protein binding, volume of distribution, water solubility, plasma clearance, dialysis membrane, blood and dialysate flow rates. • Special considerations, including high permeability dialysis, continuous renal replacement therapy (CRRT), and plasmapheresis.
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2012 Dialysis of Drugs

CRRT has the potential for the removal of large quantities of ultrafilterable drugs contained in plasma. Unfortunately, few in vivo studies have been published, and very few drugs have been studied pharmacokinetically in intensive care patients. Therefore, many guidelines for drug dosing during CRRT are extrapolated from experiences with chronic hemodialysis or from theoretical considerations based upon general principles of drug removal derived from the physicochemical characteristics of the drug and the CRRT technique employed. Knowledge of the sieving coefficient is a useful tool to predict the likelihood of a drug to cross the hemofilter membrane. It is defined as the ratio of drug concentration in the ultrafiltrate to the prefilter plasma water concentration of the drug. If the sieving coefficient is close to 1.0, the drug has relatively free passage across the filter. The following table presents sieving coefficient data from in vitro and in vivo evaluations. SIEVING COEFFICIENT
Drug Name Amikacin Amphotericin Ampicillin Cefotaxime Cefoxitin Ceftazidime Ceftriaxone Predicted Measured Condition Filter 0.95 0.88 in vivo PSa 0.10 0.40 in vivo PSa 0.80 0.69 in vivo PSa 0.62 0.51 in vivo PSa 0.30 0.30 in vitro PSa 0.90 0.90 in vivo PSa 0.10 0.71 in vivo PSa

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I PREFACE

Drug Name Cefuroxime Clindamycin Digoxin

Predicted Measured Condition Filter 0.66 0.59 in vivo PSa 0.40 0.80 0.98 0.96 0.35 0.18 1.21 1.07 in vivo in vivo in vitro in vitro in vitro in vitro in vivo in vivo in vivo in vivo in vivo in vivo in vivo in vivo in vivo in vitro in vitro in vitro in vitro in vitro in vivo in vitro in vitro in vivo in vivo in vitro PSa PSa PSa PSb AN69c PAd PSa PSa PSa PSa PSa PSa PSa PSa PSa PSa PSb AN69c PAd PSa PSa PSa AN69c PAd PSa PSa
5

Erythromycin Gentamicin Metronidazole Mezlocillin N-acetylprocainamide Nafcillin Oxacillin Phenobarbital Phenytoin

0.30 0.95 0.80 0.68 0.90 0.20 0.05 0.60 0.10

0.37 0.81 0.86 0.68 0.92 0.54 0.02 0.86 0.45 0.14 0.12 0.08 0.17 0.08

Procainamide Theophylline

0.86 0.47

0.86 0.85 0.93 0.78

Tobramycin

0.95

0.78 0.90

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32:362-75. the variability in individual patient circumstances.60 in vitro PSa 0. Marx MA. Matzke. The reader is referred to the primary literature for assistance with the dosing of specific drugs. Zarowitz BJ. Reprinted with permission. Harvey Whitney Books Company. the tables in this guide do not contain information on drug removal during CRRT. Ann Pharmacother. Armstrong DK.10 0. 6 SEE DISCLAIMER REGARDING USE OF THIS GUIDE . A primer on continuous renal replacement therapy for critically ill patients. 1998. GR.90 0.58 in vitro PAd a Amicon diafilter (polysulfone) Renal System (polysulfone) c Hospal (AN69) d Gambro (polyamide) From: Joy MS.64 in vitro AN69c 0.31 in vitro AN69c 0.75 in vitro PSb 0.76 in vivo PSa 0. b Because of the multiple techniques employed in CRRT. and the lack of in vivo data.2012 Dialysis of Drugs Drug Name Tobramycin Valproic acid Vancomycin Predicted Measured Condition Filter 0.71 in vitro PSb 0.59 in vitro AN69c 0.18 in vitro PSa 0.95 0.76 in vitro PAd 0.16 in vitro PAd 0.

the available data may conflict. no studies have been done to determine the effect of dialysis on drug removal. No information is provided on drug dialyzability with CRRT or with plasmapheresis. Variations in the duration of dialysis. These guidelines distinguish between conventional hemodialysis and high permeability (high-flux) hemodialysis where such data are available. dialysis membranes. investigational agents and medications available in other countries. the reader should consult the primary literature. For many drugs. flow rates. In some cases. and whether peritoneal dialysis is continuous or intermittent will all affect drug removal. SEE DISCLAIMER REGARDING USE OF THIS GUIDE 7 . For additional information on specific drugs. including newlyapproved medications. Conditions of dialysis used in published studies may not necessarily reflect current dialysis procedures and technology. Numerous literature sources have been used in preparing the guidelines. easy-to-read information regarding the dialyzability of drugs.I USE OF THIS GUIDE Use Of This Guide These guidelines are designed to provide extensive.

* Removed with hemoperfusion Note: In these tables. Supplemental dosing may be required or dosing after dialysis should be considered. Supplemental dosing is usually not required. conventional hemodialysis is defined as the use of a dialysis membrane whose in vitro coefficient of ultrafiltration (KUf) ≤8 mL/hour/mm Hg. 8 SEE DISCLAIMER REGARDING USE OF THIS GUIDE . In the tables. ND Indicates there are no data on drug dialyzability with this type of dialysis. but information extrapolated from studies using conventional dialysis techniques suggests significant drug removal is likely during high permeability dialysis. No Indicates that dialysis does not have a clinically important effect on plasma clearance. the KUf of the membrane(s) used is included in parentheses. molecular size or volume of distribution. High permeability hemodialysis is defined as the use of a dialysis membrane whose KUf >8 mL/hour/mm Hg. U Indicates significant drug removal is unlikely based on physicochemical characteristics of the drug such as protein binding. L Indicates no published data exist. Data also are placed in the conventional column if the literature does not specify the type of dialysis membrane employed.2012 Dialysis of Drugs Key Yes Indicates that dialysis enhances plasma clearance by 30% or more. NS Indicates the type of membrane was not specified.

5) Yes (NS) U No (NS) ND U Yes (NS) U ND No (7.I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Abacavir Abatacept Abciximab Abiraterone Acamprosate Acarbose Acebutolol (diacetolol) Acenocoumarol Acetaminophen Acetazolamide Acetohexamide Acetophenazine Acetylcysteine Aciclovir (acyclovir) Acid colloidal hydrocolloid Acitretin Acrivastine Adalimumab Adefovir Adenosine Adipiodone Agalsidase alfa Agalsidase beta Agomelatine Albendazole Albinterferon alfa-2b Albumin Albuterol Alcaftadine U U U No (NS) ND ND Yes (NS) U Yes (NS) U U U Yes (7.5) U ND No (NS) No (NS) U No (NS) ND No (40) U ND No (NS) ND ND L U L ND ND ND ND L U U ND U ND ND ND No (10) U ND ND U ND ND ND ND U U U ND ND ND U No No U U ND No U U ND U ND U ND U U ND U U U U ND 9 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

1) ND ND ND ND ND ND U ND ND L ND ND L ND ND U ND ND U U U U ND ND ND ND ND ND U ND U ND No ND No ND U No ND Yes ND Yes ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Aldesleukin Alefacept Alemtuzumab Alendronate Alfacalcidol Alfentanil Alfuzosin Alginic acid Alglucerase Aliskiren Alitretanoin Allopurinol Almotriptan Alosetron Alpha tocopherol Alprazolam Alprostadil Alteplase Altretamine Aluminum Alvimopan Amantadine Ambenonium Ambrisentan Amdinocillin Amifostine Amikacin Amiloride Aminocaproic acid Aminoglutethimide 10 ND ND U No (NS) ND U U U U ND ND Yes (NS) ND ND ND No (NS) U U ND ND ND No (NS) ND U No (NS) ND Yes (NS) ND Yes (NS) Yes (NS) ND ND U ND ND ND U U U ND ND L ND ND ND ND No (11.

36) ND L ND ND U ND ND ND ND ND U U ND No ND No U No ND No ND U U No ND No U No U No U ND No ND ND ND U U ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE 11 .1.I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Aminophylline Aminosalicylic acid Amiodarone Amisulpride Amitriptyline Amlexanox Amlodipine Ammonium chloride Amoxapine Amoxapine Amoxicillin Amphetamine Amphotericin B Amphotericin B lipid complex Ampicillin Amprenavir Amrinone Amsacrine Anagrelide Anakinra Anastrozole Ancestim Ancrod Anidulafungin Anisindione Anisoylated plasminogen streptokinase activator complex No (NS) Yes (NS) No (NS) U No (NS) ND No (NS) ND U U Yes (NS) ND No (NS) No (NS) Yes (NS) U U U ND No (NS) ND ND ND No (NS) U ND L L U U ND ND U ND ND U L ND No (10.

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Anistreplase U Antithymocyte globulin U Apomorphine U Apraclonidine ND Aprepitant No (NS) Aprotinin U Arbutamine ND Argatroban U Aripiprazole U Armodafinil ND Arsenic trioxide No (NS) Artemether U Artemether/ ND lumefantrine Articaine ND Ascorbic acid Yes (5.7-36) U ND ND U ND ND Yes (8.8) U ND L U L U U ND ND ND ND ND L U U U U ND U U ND ND U ND U U ND ND Yes U U Yes U No U U U U ND ND ND ND U SEE DISCLAIMER REGARDING USE OF THIS GUIDE .5) Asenapine U Asparaginase U Aspirin Yes (NS) Atazanavir U Atenolol Yes (NS) Atomoxetine U Atorvastatin No (NS) Atovaquone U Atracurium U Atropine No (NS) Auranofin No (NS) Azacitidine ND Azathioprine Yes (NS) Azelastine U 12 ND ND U ND U ND ND No (10.

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Azilsartan medoxomil Azithromycin Azlocillin Aztreonam Bacampicillin Baclofen Balsalazide Basiliximab Belimumab Benazepril (benazeprilat) Bendamustine Bendroflumethiazide Benserazide Benzhexol Benzphetamine Benzquinamide Benztropine Bepotastine besylate Bepridil Beractant Besifloxacin Betahistine Betaine Betamethasone Betaxolol Bethanechol Bevacizumab Bexarotene Bezafibrate No (NS) Y (NS) Yes (NS) Yes (NS) Yes (NS) ND U U ND No (NS) U No (NS) U ND ND U ND ND No (NS) U ND ND ND ND No (NS) ND U U No (NS) No (NS) L L L L Yes (60) U ND ND ND U ND U ND ND ND ND ND ND U ND ND ND ND ND ND No (NS) U U ND No No No No ND U U ND ND U U U ND ND ND ND ND U U ND ND ND ND No ND U U No 13 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

1) U L ND ND U ND ND U No (20) U U U No (10) ND ND Yes (8.2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Biapenem Bicalutamide Bimatoprost Biperiden Bisoprolol Bivalirudin Bleomycin Boceprevir Bortezomib Bosentan Brentuximab vedotin Bretylium Brinzolamide Bromazepam Bromfenac Bromocriptine Brompheniramine Budesonide Buflomedil Bumetanide Bupivacaine Buprenorphine Bupropion Buserelin Buspirone Busulfan Butalbital Butoconazole Butorphanol C1 esterase inhibitor 14 Yes (NS) U ND ND No (NS) Yes (NS) No (NS) No (NS) No (NS) U U Yes (NS) ND ND No (NS) U ND U No (NS) U U U No (NS) ND No (NS) Yes (NS) ND U U ND Yes (NS) ND ND ND ND ND ND No (NS) ND No (11.1) ND U ND ND ND U ND ND ND ND No U ND U U ND ND ND U U ND U U U U U No ND ND ND ND U U ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

1) ND L L Yes (22.2-5. 55) L ND/U ND ND Yes (NS) ND ND L ND U ND L U U ND ND U U ND U U ND U ND ND ND No No No ND/U No ND No ND ND Yes ND U ND ND U 15 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .3) ND U U ND U No (NS) ND Yes (NS) Yes (NS) No (NS) Yes (NS) ND/U No (NS) ND Yes (NS) ND ND Yes (NS) No (NS) U ND Yes (NS) No (NS) U ND ND U No (31) ND U U ND U No (8.I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Cabazitaxel Cabergoline Caffeine Calcitonin Calcitriol Calcium folinate Calcium polystyrene sulfonate Calcium sodium alginate Calfactant Canakinumab Candesartan Capecitabine Capreomycin Captopril Carbamazepine Carbenicillin Carbidopa/levodopa Carbimazole Carbinoxamine Carboplatin Carboprost Carglumic acid Carisoprodol Carmustine Carprofen Carteolol Carumonam Carvedilol U ND ND U No (4.

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Caspofungin Cefaclor Cefadroxil Cefalotin Cefamandole Cefazolin Cefdinir Cefditoren Cefepime Cefixime Cefmenoxime Cefmetazole Cefodizime Cefonicid Cefoperazone Ceforanide Cefotaxime Cefoxitin Cefpirome Cefpodoxime Cefprozil Cefradine Cefroxadine Cefsulodin Ceftaroline fosamil Ceftazidime Ceftibuten Ceftizoxime Ceftobiprole Ceftriaxone 16 No (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (6. 8) ND No (NS) Yes (NS) No (NS) Yes (NS) Yes (NS) No (NS) No (NS) No (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) ND Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) ND No (NS) U L L L L Yes (8. 60) ND L L ND ND ND L L L Yes (40) L L L ND L Yes (NS) L L L ND ND U Yes No No No No ND ND Yes No ND No No No No No No No No No ND Yes ND Yes L Yes ND No ND No SEE DISCLAIMER REGARDING USE OF THIS GUIDE .1-60) Yes (NS) ND Yes (40.

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Cefuroxime Celecoxib Cephalexin Cephalothin Cephapirin Cephazolin Cephradine Certolizumab Cetirizine Cetrorelix Cetuximab Cevimeline Chloral hydrate Chlorambucil Chloramphenicol Chlordiazepoxide Chlormethine Chloroprocaine Chloroquine Chlorothiazide Chlorpheniramine Chlorpromazine Chlorpropamide Chlorprothixene Chlorthalidone Chlorzoxazone Cholecalciferol Cholestyramine Yes (NS) U Yes (NS) Yes (NS) Yes (NS) Yes (6.7-66.7) ND U ND L ND L U U ND ND ND L U ND ND ND ND U U No U No No No No Yes U U ND U ND ND No No U U ND No U No No No U U ND U U SEE DISCLAIMER REGARDING USE OF THIS GUIDE 17 .1-60) L U No (18.5) No (NS) Yes (NS) No (NS) U ND No (NS) No (NS) Yes (NS) No (NS) No* (NS) U No (NS) ND U U L U L L L Yes (8. 8) Yes (NS) U U ND No (NS) ND Yes (5.

8.1.2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Chorionic gonadotrophin (choriogonadotropin alfa) Ciclesonide Cidofovir Cilastatin Cilazapril Cilostazol Cimetidine Cinacalcet Cinoxacin Ciprofloxacin Cisapride Cisatracurium Cisplatin Citalopram Cladribine Clarithromycin Clavulanic acid Clemastine Clevidipine Clinafloxacin Clindamycin Clobazam Clodronate Clofarabine Clofazimine Clofibrate Clomiphene U U ND Yes (NS) Yes (NS) U No (NS) No (NS) No (NS) No (NS) No (NS) U No (NS) No (8) ND ND Yes (NS) U U No (6.1) ND ND U ND U U No ND ND U No No U No U U No U ND ND Yes U U ND No ND No ND No No ND 18 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .4) No (NS) No (4.8) ND ND Yes (8.2) ND ND No (NS) No (NS) ND U U Yes (60) L L U ND U ND ND U ND Yes (NS) No (40) ND ND L U U No (8.

codeine-6 glucuronide) Colaspase Colchicine Colesevalam Colestipol Colistimethate Colistin Collagenase clostridium histolyticum Conivaptan Corifollitropin Cortisone Cotrimoxazole (sulfamethoxazole/ trimethoprim) Cromolyn sodium Cyanocobalamin U No (NS) No (NS) U No (NS) U No (NS) No (NS) U ND ND ND ND U ND U U U No U U U No U No/Yes (NS) ND U U No (NS) U U No (NS) No (NS) U U ND No (NS) Yes (NS)/Yes (NS) U No (NS) ND ND U U ND ND U U ND ND L/L U No (40. 65) U No U U No No U U ND No No/No U ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE 19 .I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Clomipramine Clonazepam Clonidine Clopidogrel Clorazepate Clotrimazole Cloxacillin Clozapine Codeine/metabolites (morphine-3 and morphine-6 glucuronides.

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Cyclacillin Cyclobenzaprine Cyclophosphamide Cycloserine Cyclosporine Cyproheptadine Cyproterone Cystadane Cysteamine Cytarabine Dabigatran Dacarbazine Daclizumab Dactinomycin Dalbavancin Dalfampridine Dalteparin Danaparoid Danazol Dantrolene Dapsone Daptomycin Darbepoetin alfa Darifenacin Darunavir Dasatinib Daunorubicin Decitabine Deferasirox Deferiprone 20 Yes (NS) U Yes (6. 62) No (11.4) ND No (NS) ND ND ND Yes (NS) ND Yes (NS) ND U ND No (NS) ND U ND ND ND Yes (NS) No (11) U U Yes (NS) U ND ND U ND L U L Yes (30. 52) U ND ND ND ND Yes (NS) L ND ND ND ND L ND ND ND ND L Yes (59.1-55) U L U ND ND U ND No U ND ND No ND ND ND No No ND ND U ND U ND No ND ND ND ND No No U U U ND ND U ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Deferoxamine Deflazacort Degarelix Delavirdine Demeclocycline Denileukin Denosumab Desferrioxamine Desipramine Desloratadine Desmopressin Desogestrel Desvenlafaxine Dexamethasone Dexamphetamine Dexchlorpheniramine Dexfenfluramine Dexlansoprazole Dexmedetomidine Dexmethylphenidate Dexpanthenol Dexrazoxane Dextran Dextroamphetamine Dextropropoxyphene Dezocine Diatrizoate Diazepam Diazoxide Dibekacin Yes (NS) No (NS) U U ND U U Yes (NS) No (NS) No (NS) ND U No (NS) No (NS) ND Yes (NS) ND U U ND ND ND U ND No (NS) ND L No (NS) Yes (NS) Yes (NS) L ND U ND ND U U L ND ND ND U U ND ND L ND U U ND ND ND U ND ND ND Yes (NS) ND L L ND U U U ND U U ND No No ND U U No ND No ND U U ND ND ND U ND No ND ND U Yes ND 21 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Diclofenac Dicloxacillin Dicyclomine Dicycloverine Didanosine Dienogest Diethylpropion Diethylstilbesterol (fosfestrol) Diflunisal Digitoxin Digoxin Digoxin immune Fab Dihydrocodeine Dihydroergotamine Diltiazem Dimenhydrinate Dimyristoyl lecithin Dinoprostone Diphenhydramine Diphenoxylate/ Atropine Dipyridamole Dirithromycin Disopyramide Disulfiram Divalproex Dobutamine Docetaxel Dofetilide 22 U No (NS) ND ND No (7.9) ND ND No (NS) No (NS) No (NS) No (NS) No (NS) ND ND No (NS) ND ND ND U ND U No (NS) No (NS) U No (NS) No (NS) No (NS) ND ND ND ND ND No (40) ND ND ND ND ND ND U ND ND ND ND ND ND ND ND ND ND U U ND ND U ND U No ND ND No ND ND ND U No No No ND ND No ND ND ND U ND ND No U U No No U ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

pegylated liposomal Doxycycline Doxylamine Dronabinol Dronedarone Droperidol Drospirenone Drotrecogin alfa Duloxetine Dutasteride Dydrogesterone Ecallantide Eculizumab Edetate calcium (ETDA) Edrophonium ND U U No (NS) Yes (NS) U U No (NS) ND No (NS) No (NS) No (NS) No (NS) ND No (NS) ND U U U U U U U ND ND U Yes (NS) ND ND U ND ND ND U U ND ND ND ND U ND ND ND ND ND U ND U U U U ND ND U L ND ND U U U ND U U U ND No No U ND ND No ND U U U U U U U ND ND U Yes ND 23 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Dolasetron Domperidone Donepezil Dopamine Doripenem Dornase alfa Dothiepin Doxacurium Doxapram Doxazosin Doxepin Doxercalciferol Doxorubicin Doxorubicin.

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Efalizumab Efavirenz Eformoterol Eletriptan Eltrombopag Emtricitabine Enalapril (enalaprilat) Encainide Enfuvirtide Enoxacin Enoxaparin Entacapone Entecavir Ephedrine Epinephrine Epirubicin Eplerenone Epoetin alfa Epoetin beta Epoprostenol Eprosartan Eptacog alfa Eptifibatide Ergocalciferol Ergometrine Ergotamine Eribulin mesylate Erlotinib Ertapenem Erythromycin 24 U No (NS) ND ND U Yes (NS) Yes (NS) No (NS) No (NS) No (NS) No (NS) U No (NS) ND ND ND No (7) No (NS) U ND U U ND ND ND ND ND U Yes (NS) No (NS) U ND ND ND U ND L ND U ND Yes (11.1-55) U ND No (60) U ND ND ND ND ND No (NS) L ND U No ND ND U ND Yes ND U No No U No ND ND ND ND No U ND U U ND ND ND ND ND U ND No SEE DISCLAIMER REGARDING USE OF THIS GUIDE .5-55) U ND ND ND ND ND No (11.

conjugated Estrone Estropipate Eszopiclone Etanercept Ethacrynic acid Ethambutol Ethanolamine oleate Ethchlorvynol Ethinyl estradiol Ethinyloestradiol Ethionamide Ethopropazine Ethosuximide Ethotoin Ethynodiol diacetate Etidronate Etodolac Etonogestrel Etoposide Etoricoxib Etravirine Everolimus ND Yes (NS) Yes (NS) U U No (NS) ND ND No (NS) U ND No (NS) No (NS) No (NS) ND No* (NS) U U U ND Yes (NS) ND ND ND No (NS) ND No (NS) No (NS) No (NS) ND ND L L U U U ND ND ND U ND U U No (80) ND ND U U No (30.I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Escitalopram Eslicarbazine Esmolol Esomeprazole Estazolam Estradiol Estramustine Estrogens. 52) ND L ND ND ND U ND No (NS) U U ND ND ND Yes U U U ND ND ND U ND U U U ND No No No U ND ND ND ND ND U ND No U U ND 25 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

22) ND ND U ND U ND ND No U ND U ND U No U ND ND U U ND ND U U U U ND ND U No ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .1) ND ND ND ND ND U ND ND ND ND ND No (8.1.2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Exametazime Exemestane Exenatide Ezetimibe Ezogabine Famciclovir (penciclovir) Famotidine Febuxostat Felbamate Felodipine Fenfluramine Fenofibrate Fenoldopam Fenoprofen Fenoterol Fentanyl Ferric gluconate Ferrous (iron) salts Ferumoxytol Fesoterodine Fexofenadine Fidaxomicin Filgrastim Finasteride Fingolimod Flavoxate Flecainide Fleroxacin Floctafenine 26 ND U ND U ND Yes (NS) No (NS) U ND No (NS) ND No (NS) U No (NS) ND U No (NS) U No (NS) ND No (NS) U No (NS) U ND ND No (NS) U ND ND U ND U ND L ND U ND U ND U ND U ND No (10.

1) Yes (18-60) Fosfomycin Yes (NS) L Fosinopril (fosinoprilat) No (NS) ND Fosphenytoin U U SEE DISCLAIMER REGARDING USE OF THIS GUIDE ND ND Yes Yes ND ND ND ND ND No ND ND U U No U U U U ND ND ND ND U U U ND ND No U 27 .I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Floxuridine ND ND Flucloxacillin No (NS) ND Fluconazole Yes (NS) L Flucytosine Yes (NS) L Fludarabine ND ND Fludrocortisone ND ND Flumazenil ND ND Flunitrazepam ND ND Fluorouracil/FBAL No (NS)/ND Yes (71)/Yes (40) Fluoxetine No (NS) U Fluoxymesterone ND ND Flupenthixol ND ND Fluphenazine U ND Flurazepam No (NS) ND Flurbiprofen U U Flutamide No (NS) ND Fluticasone U U Fluvastatin No (NS) U Fluvoxamine U No (NS) Folic acid Yes (NS) L Follitropin alfa ND ND Follitropin beta ND ND Fomepizole Yes (NS) L Fondaparinux No (NS) ND Fosamprenavir U U Fosaprepitant No (NS) U Foscarnet Yes (4.

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Fotemustine Frovatriptan Frusemide Fulvestrant Furosemide Fusidic acid Gabapentin Gadobenate Gadobutrol Gadodiamide Gadofosveset Gadolinium Gadopentetate Gadoteric acid Gadoteridol Gadoversetamide Gadoxetate Galantamine Gallamine Gallium Gallopamil Galsulfase Ganciclovir Ganirelix Garenoxacin Gatifloxacin Geftinib Gemcitabine Gemfibrozil Gemifloxacin 28 ND ND No (NS) U No (NS) No (NS) Yes (NS) ND Yes (5.5) Yes (NS) ND Yes (NS) Yes (NS) No (NS) ND ND Yes (NS) ND ND ND U U Yes (NS) ND No (NS) ND U Yes (7) No (NS) No (NS) ND ND U U U ND L ND L L ND ND L U ND Yes (NS) L ND ND ND U U L ND ND ND No (20) Yes (53. 58) U ND ND ND U U U No ND ND ND No ND ND ND U ND ND ND ND ND ND U U ND ND No ND U ND No ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

2-60) U ND ND U U U U ND ND U ND ND ND U ND ND ND ND ND U ND ND ND ND ND ND U U Yes U ND ND U U U U U No U No ND U U ND ND ND ND ND U ND ND No ND ND ND No 29 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Gemtuzumab Gentamicin Gestodene Gestrinone Glatiramer Glibenclamide Gliclazide Glimepiride Glipizide Glucagon Glutethimide Glyburide Glyceryl trinitrate Glycopyrrolate Gold sodium thiomalate Golimumab Goserelin Granisetron Grepafloxacin Griseofulvin Guaifenesin Guanabenz Guanadrel Guanethidine Guanfacine Guanidine H1N1 Vaccine Halofantrine Haloperidol U Yes (NS) U ND ND No (NS) U U U U No* (NS) No (NS) No (NS) ND No (NS) U ND ND ND ND ND U ND ND No (NS) ND ND ND No (NS) U Yes (13.

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Heparin Hexamine Hexobarbital Hirudin Human growth hormone Hydralazine Hydrochlorothiazide Hydrocodone Hydrocortisone Hydromorphone/ hydromorphone-3glucuronide Hydroxocobalamin Hydroxycarbamide Hydroxychloroquine Hydroxyurea Hydroxyzine Ibandronate Ibritumomab Ibuprofen Ibutilide Icatibant Idarubicin Idebenone Idursulfase Ifosfamide Iloperidone Iloprost Imatinib No (NS) ND No (NS) No (4. 65) ND ND ND U Yes (8.6) U ND No (NS) ND ND ND Yes (20-90) U ND ND ND ND ND/L No (40.3-6.5) U No (NS) ND No (NS) No (NS) ND U No (NS) ND ND U U U Yes (1.1) U U ND ND U U U L U ND U No ND U ND U No U ND U U ND U ND U No ND U U ND ND U U U ND U ND U 30 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .5) U No (NS) No (NS) ND U No/Yes (7.

5-6.2) Ioflupane I-123 ND Iohexol Yes (NS) Iomeprol Yes (6.8) Iopamidol Yes (4.1.1-62) L L Yes (15.I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Imidapril (imidaprilat) No (NS) Imiglucerase U Imipenem Yes (NS) Imipramine No (NS) Immune globulin U Indacaterol U Indapamide No (NS) Indinavir U Indomethacin No (NS) Infliximab U Insulin No (NS) Insulin aspart U Insulin detemir No (NS) Insulin glargine U Insulin glulisine U Insulin lispro U Interferons No (NS) Iobenguane No (NS) Iodipamide ND Iodixanol Yes (3. 4.8) Iopromide Yes (5.5) L ND U U Yes No U U U ND U U No U ND U ND U No ND ND ND ND ND Yes Yes ND ND ND ND ND ND 31 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .8) Iotrolan Yes (NS) Ioversol Yes (6.5) L L Yes (8.3) Ioxaglic acid L Ioxilan Yes (NS) Ioxitalamic acid ND U U L U ND U ND No (40) U U ND ND U ND ND ND Yes (20-33) ND ND L ND Yes (15.

1-10.2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Ipilimumab Irbesartan Irinotecan/SN-38 Iron dextran Iron polymaltose complex Iron sorbitol-citric acid complex Iron sucrose (saccharate) Isocarboxazid Isoniazid Isoprenaline Isoproterenol Isosorbide dinitrate Isosorbide mononitrate Isotretinoin Isradipine Itraconazole Ivabradine Ivermectin Ixabepilone Kanamycin Ketamine Ketoconazole Ketoprofen Ketorolac Ketotifen L-tryptophan Labetolol U No (NS) U/U U U ND U ND No (NS) ND ND No (NS) Yes (NS) U No (NS) No (NS) ND ND ND Yes (NS) No (NS) No (NS) U U ND U No (NS) U ND No (8.5) No (8.5)/No (8.1-40) ND U ND U/U U U ND U ND No ND ND No No U No U ND ND ND Yes U No U U ND ND No 32 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .1-55) ND No (80) ND ND ND L U U No (65) ND ND ND L ND ND U U ND No (8.1) U ND No (11.

4) ND ND U U U U No (8.I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Lacosamide No (NS) Lactulose U Lamivudine No (NS) Lamotrigine No (NS) Lanreotide ND Lansoprazole No (NS) Lanthanum carbonate No (NS) Lapatinib U Laronidase U Leflunomide No (NS) Lenalidomide Yes (NS) Lenograstim No (NS) Lepirudin No (4.4) ND U No (11.1) ND ND Yes (20-90) ND ND ND ND ND ND L ND L U U No (13.2) Lercanidipine ND Letrozole ND Leucovorin ND Leuprolide ND Leuprorelin ND Levamisole ND Levetiracetam Yes (NS) Levobupivacaine U Levocarnitine Yes (NS) Levocetirizine No (NS) Levodopa U Levofloxacin U Levoleucovorin ND Levomethadyl U Levonorgestrel U Levorphanol ND Levosimendan No (6.2) ND U ND ND U U U No U ND U U U U No ND U ND ND ND ND ND ND ND ND U ND U U No ND U U ND U 33 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .3-6.

1-52) U U ND U U U U ND L U ND U U U ND No ND ND U ND ND Yes No U ND U ND No U No U U ND U U U U ND Yes U ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Levothyroxine Lidocaine Lignocaine Linagliptin Lincomycin Linezolid Liothyronine Liraglutide Lisdexamfetamine Lisinopril Lithium Lomefloxacin Lomustine Loperamide Lopinavir Loracarbef Loratadine Lorazepam Losartan Loteprednol etabonate Lovastatin Loxapine Lubiprostone Lumefantrine Lurasidone Macrogol 3350 Mangafodipir Mannitol Maprotiline Maraviroc 34 U No (NS) No (NS) ND No (NS) Yes (NS) ND U ND Yes (NS) Yes (NS) No (NS) No (NS) ND U Yes (NS) No (NS) No (NS) No (NS) U U ND U U U U ND Yes (NS) No (NS) ND ND ND ND ND ND Yes (9.3-65) ND U ND L Yes (40. 70) ND ND ND No (NS) L U ND No (10.

1)/Yes (8.5) ND Mesalazine Yes (5.I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Mazindol ND ND Mebendazole No (NS) U Mebeverine ND ND Mecamylamine ND ND Mecasermin ND ND Mechlorethamine U U Meclofenamate U ND Medroxyprogesterone U U Mefenamic acid No (NS) U Mefloquine U ND Megestrol acetate ND ND Melatonin/6Yes (NS) L sulfatoxymelatonin Meloxicam No (NS) U Melphalan No (NS) ND Memantine ND ND Menadiol ND ND Menotropins ND ND Mepenzolate ND ND Meperidine/ No (NS)/ND No (8.5) ND Mesna ND ND Mesoridazine U ND Mesterolone ND ND Mestranol U U SEE DISCLAIMER REGARDING USE OF THIS GUIDE ND U ND ND ND U U U U U ND ND U ND ND ND ND ND U/ND Yes ND ND U U ND U ND U 35 .1) normeperidine Meprobamate Yes (NS) L Mercaptopurine Yes (NS) L Meropenem Yes (NS) L Mesalamine (5-ASA) Yes (5.

60) ND ND U ND ND U L ND ND ND L ND U U L Yes (56) ND ND ND ND No No ND No No ND U Yes ND ND U ND ND U Yes ND ND U ND ND No U ND No SEE DISCLAIMER REGARDING USE OF THIS GUIDE .2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Mesuximide Metaproterenol Metaxalone Metformin Methadone Methaqualone Methenamine Methicillin Methimazole Methocarbamol Methohexital Methotrexate Methotrimeprazine Methoxsalen Methoxy polyethylene glycol-epoetin beta Methscopolamine Methsuximide Methyl aminolevulinate HCl Methyldopa Methylergonovine Methylnaltrexone Methylphenidate Methylprednisolone Methysergide Metoclopramide Metolazone Metoprolol Metronidazole 36 ND ND ND Yes (NS) No (NS) No (NS) ND No (NS) No (NS) ND U Yes (NS) ND ND U ND ND U Yes (NS) ND ND U Yes (NS) ND No (NS) No (NS) Yes (NS) Yes (NS) ND ND ND L U ND ND U ND ND U Yes (20.

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Mexiletine Mezlocillin Mianserin Micafungin Miconazole Midazolam Midodrine (deglymidodrine) Mifepristone Miglitol Miglustat Milnacipran Milrinone Minocycline Minoxidil Mirtazapine Mirtazapine Misoprostol Mitomycin Mitotane Mitoxantrone Mitozantrone Mivacurium Moclobemide Modafinil Moexipril Molindone Mometasone Montelukast Moricizine Yes (NS) Yes (NS) No (NS) U No (NS) No (NS) ND U ND ND U ND No (NS) Yes (NS) U No (7.5) U ND ND No (NS) No (NS) ND ND ND ND U ND U U L L ND U U U Yes (8.1) U ND ND U ND ND L ND ND ND ND ND U U ND ND ND ND ND ND ND ND No No ND U No U ND U ND ND U ND No Yes U U U ND ND No No ND ND ND ND U ND U U 37 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

9) U ND ND No (NS) U ND ND No (NS) U ND ND U U U/Yes (NS) U ND U No (NS) U U Yes (NS) U/Yes (NS) U ND U ND U No (71) L U No No ND U No ND U ND ND ND No ND U U ND U ND U ND U U/ND U ND U ND U No Yes SEE DISCLAIMER REGARDING USE OF THIS GUIDE .1-5.1) ND ND ND ND U ND No (NS) U ND ND No (NS) U Yes (NS) L ND ND ND ND No (NS) ND ND ND U U No (4. 10.1.2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Moroctocog alfa Morphine Moxifloxacin Moxonidine Muromonab-CD3 Mycophenolate Nabilone Nabumetone Nadolol Nadroparin Nafarelin Nafcillin Nalbuphine Nalidixic acid Nalmefene Naloxone Naltrexone Nandrolone Naproxen Naratriptan Natalizumab Nateglinide/M1 metabolite Nebivolol Nedocromil Nefazodone Nefopam Nelarabine Nelfinavir Neomycin 38 U U ND Yes (8.

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Nesiritide Netilmicin Nevirapine Niacin Niacinamide Nicardipine Nicorandil Nicotine Nicotinic acid Nifedipine Nilotinib Nilutamide Nimodipine Nisoldipine Nitazoxanide Nitisinone Nitrazepam Nitrendipine Nitrofurantoin Nitroglycerin Nitroprusside Nizatidine Nomifensine Nonacog alfa Noradrenaline Norelgestromin Norepinephrine Norethindrone Norethisterone Norfloxacin U Yes (NS) ND ND ND No (NS) ND ND ND No (NS) U ND No (NS) No (NS) U ND ND No (NS) Yes (NS) No (NS) Yes (NS) No (NS) ND U ND ND ND ND ND No (NS) U L Yes (40) ND ND U ND ND ND U U ND U U U ND ND U L ND L ND ND U ND ND ND ND ND ND U Yes Yes ND ND U ND ND ND No U ND No No U ND ND U ND No Yes No ND U ND ND ND No No U 39 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

5) U No (NS) ND U ND ND ND ND U L U L U ND L U U ND No ND U U ND ND ND ND U No No U U U ND ND U U U ND U No U ND Yes No SEE DISCLAIMER REGARDING USE OF THIS GUIDE . conjugated Ofatumumab Ofloxacin Olanzapine Olmesartan Olsalazine Omalizumab Omapatrilat Omega-3-acid ethyl esters Omeprazole Ondansetron Oprelvekin Orbofiban Orlistat Ornidazole Ornipressin Orphenadrine Oseltamivir Oxacillin 40 U ND No (NS) ND U U Yes (NS) No (NS) ND ND U Yes (6.8-4.0) No (NS) No (NS) U U No (NS) ND U U U Yes (NS) U Yes (NS) U ND Yes (2.2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Norgestimate Norgestrel Nortriptyline Nylidrin Nystatin Octocog alfa Octreotide Oestradiol Oestriol Oestrogens.0) No (NS) U ND U ND U U L ND ND ND U Yes (8.

1) U U Yes (NS) No (NS) No (5.4) U ND U No (5.5) ND No (NS) U Yes (71. 60) L U ND ND U U ND U U U ND ND U No ND ND ND U No ND ND U ND ND U ND U U U U No U ND ND U U 41 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Oxaliplatin Oxandrolone Oxaprozin Oxazepam Oxcarbazepine Oxpentifylline Oxprenolol Oxtriphylline Oxybutynin Oxycodone Oxymetholone Oxymorphone Paclitaxel Palifermin Paliperidone Palivizumab Palonosetron Pamidronate Pancreatic extract Pancuronium Panitumumab Pantoprazole Papaverine Para-aminosalicylate Paracetamol Parecoxib Paricalcitol Paromomycin Paroxetine Pazopanib ND U No (NS) No (NS) ND U U Yes (NS) ND ND ND U No (NS) U ND U ND Yes (6. NS) U ND ND ND ND U L ND Yes (48) ND U U ND ND U ND L U ND U U U No (30.

7)/Yes (20-33) U U ND L ND L L ND U L ND ND ND U ND ND U U ND L L U No U U U U U U U ND No No ND No No U ND U ND ND U ND ND U U ND ND ND U SEE DISCLAIMER REGARDING USE OF THIS GUIDE .2011 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Pefloxacin Pegademase Pegaspargase Pegfilgrastim Peginterferon alfa-2a Peginterferon alfa-2b Pegloticase Pegvisomant Pemetrexed Pemoline Penbutolol Penicillamine Penicillin Pentamidine Pentastarch Pentazocine Pentobarbital Pentosan polysulfate Pentostatin Pentoxifylline Perflexane Perflutren Pergolide Perhexiline Pericyazine Perindopril Perindopril (perindoprilat) Perphenazine 42 No (NS) U U No (NS) U U U U ND Yes (NS) No (NS) Yes (NS) Yes (NS) No (NS) U Yes (NS) No (NS) ND ND U ND ND U U ND Yes (NS) Yes (NS) U ND U ND U No (8.7-33) No (8.

1) Pethidine/norpethidine No (NS)/ND No (8.I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Pethidine No (NS) No (8.1)/Yes (8.1) Phenacetin ND ND Phenazopyridine ND ND Phendimetrazine ND ND Phenelzine ND ND Phenindione ND ND Pheniramine ND ND Phenobarbital Yes (NS) Yes (60) Phenobarbitone Yes (NS) Yes (60) Phenoxybenzamine ND ND Phentermine ND ND Phentolamine ND ND Phenylbutazone No (NS) U Phenyltoloxamine ND ND Phenytoin No (NS) Yes (36) Phytomenadione ND ND Phytonadione ND ND Pilocarpine ND ND Pimagedine Yes (NS) ND (aminoguanidine) Pimozide ND ND Pinaverium U U Pindolol ND ND Pioglitazone No (NS) U Piperacillin Yes (NS) L Piperazine oestrone ND ND Pipotiazine ND ND Piroxicam U U Pitavastatin U U SEE DISCLAIMER REGARDING USE OF THIS GUIDE U U/ND ND ND ND ND ND ND Yes Yes ND ND ND U ND No ND ND ND ND ND U ND U No ND ND U U 43 .

2011 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Pivmecillinam Pizotifen Pizotyline Plerixafor Plicamycin Pneumococcal vaccine Polidocanol Polyethylene glycol Polythiazide Poractant alfa Porfimer Posaconazole Pralatrexate Pralidoxime Pramipexole Pramlintide Prasugrel Pravastatin Prazepam Praziquantel Prazosin Prednisolone Prednisone Pregabalin Primaquine Primidone Probenecid Probucol Procainamide/N-acetyl procainamide (NAPA) 44 No (NS) U U ND ND ND ND U No (NS) ND No (NS) No (NS) ND ND No (NS) ND U No (5.3) No (NS) No (NS) No (NS) U No (NS) Yes (NS) No (NS) Yes (NS) U No (NS) Yes (NS)/ Yes (NS) ND U U L ND ND ND U ND ND U U ND ND U ND U ND ND ND U No (NS) ND L U L U ND L/L U U U ND ND ND ND U No ND U U ND ND U ND U ND U ND No U No ND U ND U No No/No SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Procarbazine Prochlorperazine Procyclidine Profenamine Progesterone Proguanil Promazine Promethazine Propafenone Propantheline Propofol Propoxyphene Propranolol Propylthiouracil Protriptyline Pseudoephedrine Pyrantel Pyrazinamide Pyridostigmine Pyridoxine Pyrilamine Pyrimethamine Quazepam Quetiapine Quinagolide Quinapril (quinaprilat) Quinidine Quinine Quinupristin/ dalfopristin ND U ND ND U No (NS) U No (NS) No (NS) ND U No (NS) No (NS) No (NS) No (NS) No (NS) ND Yes (NS) ND ND ND ND U ND U No (NS) No* (NS) No (NS) ND ND U ND ND U U ND U U ND U ND U ND U U ND Yes (80) ND Yes (36) ND ND U ND U U U U ND ND U ND ND U U U U No ND U No No ND No U ND No ND ND ND ND U ND U No No No No/No SEE DISCLAIMER REGARDING USE OF THIS GUIDE 45 .

2011 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Rabeprazole Raloxifene Raltegravir Raltitrexed Ramelteon Ramipril (ramiprilat) Ranibizumab Ranitidine Ranolazine Rapacuronium Rasagiline Rasburicase Reboxetine Recainam Remifentanil Repaglinide Reserpine Reteplase Reviparin Ribavirin Rifabutin Rifampicin Rifampin Rifapentine Rifaximin Rilmenidine Rilonacept Rilpivirine Rilpivirine Riluzole 46 U U Yes (NS) ND ND No (NS) U No (NS) ND ND ND U U No (NS) U U No (NS) ND No (NS) No (NS) U No (NS) No (NS) U U No (NS) U U U U U U L ND ND ND U Yes (NS) ND ND ND U U ND U No (60) U ND ND U No (40) No (80) No (80) U U ND U U U U U U ND ND ND ND U No ND ND ND U U U U U No ND U U U No No U U U U U U U SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Rimantadine Risperidone Ritodrine Ritonavir Rituximab Rivaroxaban Rivastigmine Rizatriptan Rocuronium Roflumilast Romidepsin Romiplostim Ropinirole Ropivacaine Rosiglitazone Rosuvastatin Rotigotine Roxithromycin Ruboxistaurin Rufinamide Rufloxacin Sacrosidase Salbutamol Salcatonin Salmeterol Salsalate Sapropterin Saquinavir Sargramostim Saxagliptin No (NS) ND Yes (NS) Yes (NS) No (NS) ND ND ND ND U U ND U U No (NS) No (NS) U ND U No (NS) ND ND No (NS) U ND Yes (NS) ND U ND Yes (NS) U ND L No (40) U ND ND ND ND U U ND U U U ND U ND U ND ND ND ND U ND L ND No (40) ND Yes (NS) U ND Yes No U ND ND ND ND U U ND U U No U U No U U ND ND U U ND No ND U ND ND 47 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Secobarbital Secretin Selegiline Sermorelin Sertindole Sertraline Sevelamer Sevoflurane Sibutramine Sildenafil Silodosin Silver sulfadiazine Simethicone Simvastatin Sirolimus Sisomicin Sitagliptin Sitaxsentan Sodium aurothiomalate Sodium calcium edetate Sodium chondroitin sulfate Sodium clodronate Sodium cromoglycate Sodium diatrizoate Sodium fusidate Sodium nitroprusside Sodium oxybate No (NS) ND ND ND No (NS) No (NS) U ND U U U No (NS) U U No (NS) Yes (NS) No (NS) U U Yes (NS) ND ND U L No (NS) Yes (NS) ND ND ND ND ND U U U ND U No (65) U ND U U U L ND U U L ND Yes (8.1) U Yes (NS) ND L ND No ND ND ND U U U ND U U U U U U U ND ND U U Yes ND No U ND No Yes ND 48 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Sodium polystyrene sulfonate Sodium thiosulfate Sodium valproate Solifenacin Somatropin Sorafenib Sotalol Sparfloxacin Spectinomycin Spinosad Spiramycin Spirapril (spiraprilat) Spironolactone Stanozolol Stavudine Streptokinase Streptomycin Streptozocin Sucralfate Sufentanil Sulbactam Sulfadiazine Sulfadoxine Sulfamethoxazole Sulfapyridine Sulfasalazine Sulfinpyrazone Sulfisoxazole Sulindac U ND No (NS) U No (NS) L Yes (NS) ND Yes (NS) U ND U U ND Yes (NS) U Yes (NS) ND No (NS) U Yes (NS) ND ND Yes (NS) ND U No (NS) Yes (NS) No (NS) U Yes (NS) Yes (62) U U Yes (NS) L ND L U ND ND ND ND Yes (NS) U L ND ND U L ND ND L ND U U L ND U ND No U U U ND ND Yes U ND U U ND ND U Yes ND No U No ND ND No ND U U Yes U 49 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Sulthiame Sumatriptan Sunitinib Tacrine Tacrolimus Tadalafil Talinolol Tamoxifen Tamsulosin Tapentadol Tazobactam Tefibazumab Tegafur Tegaserod Teicoplanin Telaprevir Telavancin Telbivudine Telithromycin Telmisartan Temazepam Temocillin Temozolomide Temsirolimus Tenecteplase Teniposide Tenofovir Terazosin Terbinafine Terbutaline 50 ND ND U ND No (NS) No (NS) No (NS) ND U U Yes (NS) No (NS) Yes (NS) No (NS) No (NS) ND ND No (NS) ND No (NS) No (NS) Yes (NS) ND No (NS) U U ND No (NS) U ND ND ND No (NS) ND U U ND ND U U L ND L U ND ND L ND ND ND U L ND U U ND Yes (50) U U ND ND ND U ND U U ND ND U U No U ND U No ND U ND ND U U No ND U U U ND No U ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Teriparatide Tesamorelin acetate Testolactone Testosterone Tetrabenazine Tetracycline Thalidomide Thallous chloride Theophylline Thiabendazole Thiamazole Thiamine Thiethylperazine Thioguanine Thioproperazine Thioridazine Thiotepa Thiothixene Thrombin alfa Thyrotropin alfa Thyroxine Tiagabine Tiaprofenic acid Tibolone Ticagrelor Ticarcillin Ticlopidine Tigecycline Tilidine Tiludronate ND U ND No (NS) ND No (NS) U ND Yes (NS) ND No (NS) No (NS) ND ND ND U ND U U U U No (NS) U ND U Yes (NS) U No (NS) No (NS) U ND U ND U ND ND No (65) ND L ND ND ND ND ND ND U ND ND U U ND U U ND U L U ND ND ND ND U ND U ND No U ND No ND No U ND ND ND U ND U U U U U U ND U No U U U U 51 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Timolol Tinidazole Tinzaparin Tiotropium Tipranavir Tirofiban Tizanidine Tobramycin Tocainide Tocilizumab Tocopherol Tolazamide Tolbutamide Tolcapone Tolmetin Tolterodine Tolvaptan Topiramate Topotecan Toremifene Torsemide Tositumomab Tosufloxacin Trabectedin Tramadol Tramazoline Trandolapril (trandolaprilat) Tranexamic acid Tranylcypromine 52 No (NS) Yes (NS) U ND U Yes (NS) ND Yes (NS) Yes (NS) ND ND U No (NS) U U U U Yes (NS) Yes (8.0) U No (NS) U No (NS) No (NS) No (NS) ND Yes (NS) ND ND ND L ND ND U L ND L L ND ND ND ND U U U U L L U U U ND ND Yes (50) ND L ND ND No ND ND ND U ND ND Yes ND ND ND U U U U U U ND ND U U U ND ND ND ND ND ND ND SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

1-40) ND ND U U ND L ND U U U ND ND U ND No U ND ND ND ND No U U ND ND ND U ND ND ND ND ND U U ND No 53 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Trapidil Trastuzumab Trazodone Treprostinil Tretinoin Triamterene Triazolam Trientine Trifluoperazine Triflupromazine Trihexyphenidyl Trimebutine Trimeprazine Trimethobenzamide Trimethoprim Trimetrexate Trimipramine Triprolidine Triptorelin Trisodium citrate Tropisetron Trospium Trovafloxacin Tryptophan Ulipristal Urofollitropin Ursodeoxycholic acid Ursodiol Ustekinumab Valaciclovir ND U U U ND ND No (NS) ND No (NS) U ND ND ND ND Yes (NS) U U ND ND ND U ND No (NS) U ND ND U U ND Yes (NS) ND U ND U ND ND ND ND U ND ND ND ND ND L U U ND ND ND U ND ND No (8.

2012 Dialysis of Drugs Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Valacyclovir Valganciclovir Valproic acid Valrubicin Valsartan Vancomycin Vandetanib Vardenafil Varenicline Vecuronium Velaglucerase Velosulin Vemurafenib Venlafaxine Verapamil Verteporfin Vigabatrin Vilazodone Vildagliptin Vinblastine Vincristine Vinorelbine Voriconazole Vorinostat Warfarin Zafirlukast Zalcitabine Zaleplon Zanamivir Yes (NS) Yes (NS) No (NS) ND No (NS) No (NS) ND ND Yes (NS) U U U U No (NS) No (NS) ND Yes (NS) U ND ND ND ND No (NS) ND No (NS) U ND ND ND L ND Yes (62) ND ND Yes (10.1-60) ND ND ND ND U U U U ND ND L U ND ND ND ND No (NS) ND ND U ND ND ND No ND No ND U Yes ND ND ND U U U U U No ND ND U ND ND ND ND No ND No U ND ND ND 54 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

I CHART Drug HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Zidovudine/GZDV Zileuton Zinc Ziprasidone Zoledronic acid Zolmitriptan Zolpidem Zonisamide Zopiclone Zuclopenthixol No (NS)/ Yes (NS) U ND No (NS) ND U No (NS) Yes (NS) No (NS) ND ND/L No (8. 10.3.1) ND U ND U U ND ND ND No/Yes U ND U ND U U ND U ND Drugs of Abuse HEMODIALYSIS Conventional High Permeability Peritoneal (KUf) (KUf) Dialysis Drug Amphetamine Cocaine Ethanol Heroin Lysergide (LSD) Marijuana (THC) MDMA (Ecstasy) Mescaline (peyote) Nicotine Phencyclidine (PCP) Psilocybin ND No (NS) Yes (NS) U U U ND U ND U ND ND ND L ND ND ND ND ND ND ND ND ND U ND U U U ND U No U ND 55 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .

Mueller BA. in Nissenson AR. Crit Care Med. 2. et al. Atkinson Jr AJ. Atkinson AJ. Olyaei AJ. Peterson NT. Clin Pharmacol Ther 2009. 6. Plumb TJ. Cronin SM. Handbook of Dialysis Therapy (4th ed). Pasko DA. Antibiotic dosing during sustained low-efficiency dialysis: special considerations in adult critically ill patients. 2007. 4. 2011. Edwards DJ. Kidney Int. 2008. Schetz M.2012 Dialysis of Drugs References 1. epub. 2001. Freebairn R. Smoyer WE. Matzke GR. Heintz BH. Drug removal by plasmapheresis: an evidence-based review. Philadelphia: American College of Physicians. Drug dosing in continuous renal replacement therapy: general rules.Sept. Ibrahim RB. Drug prescribing in renal failure. Drug dosing considerations in patients with acute and chronic kidney disease – a clinical update from Kidney Disease: Improving Global Outcomes (KDIGO). Fine RN (eds).37:2268-2282. 5th ed. 56 SEE DISCLAIMER REGARDING USE OF THIS GUIDE .13:645-651. Lipman J. Bogard KN. Choi G.27:1529-1549. Dager WE.29:562-577. Brier ME. Pharmacotherapy. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Joynt GM. Curr Opin Crit Care. et al. Matzke GR. 19. 2009. 2007. Umans JG. 8. Crit Care Med. 7. Principles of drug usage in dialysis patients. 2009. Tian Q. Swerdlow P. Aronoff GR. Berns JS. Bennett WM. 39:560-570. Pharmacotherapy. Aronoff GR. Bennett WM. Gomersall CD. Kasbekar N. Liu C. Principles of antibacterial dosing in continuous renal replacement therapy. Cha R. Philadelphia: Saunders Elsevier. 5. Pharmacokinetic studies in hemodialysis patients. Murphy BD. 86: 548–552. 3. 2007.

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