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Use of Cosmetics with Chemicals can Cause Health Problems Heavy metal toxicity to the humans & animals is the

result of long term low or high level exposure to pollutants common in our environment including in air we breathe, water, food & numerous consumer products like cosmetics & toiletries. Exposure to toxic metals is associated with many chronic diseases. Recent research has found that even low levels of lead, mercury, cadmium, aluminum & arsenic can cause a wide variety of health problems. According to a latest finding, many cosmetics have enough heavy metals & toxins in them to impact the health of regular users. Following paragraphs gives an idea that how dangerous could be the use of cosmetics with chemical. Present in lipstic, kajal, talcum powder & hair colour. 1. Impairs liver & renal functions 2. Proven neuro-toxin. Causes learning & behavioural problems 3. Weakens the immune system 4. Causes haepatic injury (breakdown of red blood cells leadig to haemoglobin loss) 5. Pregnancy complications, such as low birthweight baby, preterm delivery & poor mental development. ARSENIC Present in lipstic & hair colour 1. Causes nausea, vommiting, diarrhoea 2. Decreases production of white blood cells & red blood cells 3. Causes abnormal heart rhythm, blood vessel damage 4. Irritation, inflammation, ulceration of mucous membranes COPPER Present in lipstic & hair colour 1. Physical & mental fatigue 2. Schizophrenia, depression, mood swings, sleep disorders 3. Arthritis 4. Increased risk of infections 5. Nausea & vomiting NICKEL, COBALT AND CHROMIUM Present in lipstic & hair color 1. Asthma 2. Nausea, vomitting & diarrhoea 3. Oxidative stress 4. Paraben preservatives 5. Present in lipstic & shampoo 6. Eye irritation 7. Neck tissue damage

whether federal. heavy metals will refer to lead. For the purpose of this guidance document. supersede or limit the requirements under the legislation. In case of any discrepancy between this summary and the legislation. Definitions bw . mercury and antimony.NICOTINE Present in tooth powder 1. The focus is on the heavy metals with known significant toxicological properties: lead. cadmium. provincial or territorial. arsenic. This document is not intended to substitute for. may also apply to the products that are covered by this guidance document. Purpose/scope Many heavy metals are not acceptable as ingredients in cosmetic products sold in Canada as they may cause injury to the health of the user. arsenic.kilogram L . Causes cancer 1. In addition. Yet they may still be found in cosmetics as impurities due to the persistent nature of these substances and the fact that they are found in the natural environment. kg .litre manufacturer . the legislation will prevail.any metallic chemical element that has a relatively high density. 2. antimony and mercury and their compounds.body weight g .gram (1 g = 0.001 kg) heavy metal . cadmium. The purpose of this guidance is to determine and communicate appropriate limits of these impurities in cosmetic products. which is in contravention of the general prohibition found in section 16 of the Food and Drugs Act. other laws.

Lead. design. or manufactures and sells..provisional tolerable daily intake (PTDI = PTWI ÷ 7) PTWI . Background Heavy metals are found naturally in the environment in rocks. a cosmetic under its own name or under a trade-mark.provisional tolerable weekly intake (PTWI = PTDI × 7) 3. 1 mg/L) PTDI . arsenic.The Cosmetic Regulations define "manufacturer" as a person. the progressive hair dye lead acetate and a number of tattoo pigments such as red cinnabar (mercuric sulfide). mercury.belonging to the class of chemical compounds having a carbon basis.microgram mg . a partnership or an unincorporated association that per billion (1 ppb = 1 µg/kg = 1 µg/L) ppm . which is in contravention of the general prohibition found in section 16 of the Food and Drugs Act. trade name or other name or mark owned or controlled by it. The Cosmetic Ingredient Hotlist is an administrative tool to communicate to manufacturers and others that certain substances may cause injury to the health of the user.milligram organic . 1 mg/kg. cadmium. soil and water. Examples include the preservative thimerosal (mercury). The Government of Canada has implemented numerous measures to reduce the amount of heavy metals to which Canadians are exposed. and may therefore be found in pigments and other raw materials in all industries including the cosmetics industry. . antimony and chromium are heavy metal ingredients that are listed as prohibited on the Cosmetic Ingredient per million (1 ppm = 1µg/g. Some of these metals have been used as cosmetic ingredients in the past. µg . including not allowing their intentional use in cosmetics. ppb .

Exposure Heavy metals are naturally occurring. Health Canada's recommended impurity limits for cosmetic products are listed in section 4 of this document. as well as from hand-to-mouth contact after exposure to cosmetics containing heavy metal impurities. Dermal absorption of heavy metals is typically low.2.010 ppm) of waterFootnote5. cadmium.1. with absorption of individual elements influenced by a number of factors including physical-chemical properties of themixturesFootnote1.Given that the issue of heavy metals as deliberate cosmetic ingredients has been addressed. 3. 3. mercury and antimony.1. 3. Inhalation exposure is expected to be negligible. are present in the environment and can make their way in trace quantities into raw materials.1 ppmFootnote6. The Guidelines for Canadian Drinking Water Quality recommend a lead Maximum Acceptable Concentration (MAC) of 0. These substances end up in the products we consume and use every day. as are pregnant women/fetuses. as well as recommended impurity limits for certain types of products. Children absorb about 50% of ingested leadFootnote2. the kidneys and on the hematopoietic (blood forming) system. arsenic. few studies have provided quantitative estimates of dermal absorption and the contribution of the dermal intake to lead body burdenFootnote2. Exposure to lead is typically greater in children. The metals of primary toxicological concern in cosmetics are lead. who are also more susceptible to the effects of lead than adults. lead acetate is now not acceptable in cosmetic products in Canada. . Lead Lead exerts adverse effects on numerous organs and systems including the central nervous system (CNS). attention turns to the presence of these substances as impurities. The toxicity of these substances. Exposure to lead from cosmetics previously occurred from use of progressive hair dye preparations containing lead acetateFootnote4. Dermal absorption of inorganic lead has been demonstrated in animals and human subjects. The identification of causal relationships between exposure and effects is complicated by the delay between the time of lead exposure and the onset of effectsFootnote3.010 mg/L (0. Inorganic lead crosses the skin less readily with a low permeability co-efficient of about 10-4 cm/hour. Children are particularly at risk for the subtle adverse effects of chronic low-dose lead exposure. however. Dermal exposure is expected to be the most significant route for cosmetic products since the majority of cosmetics are applied to the skin. Oral exposure can occur for cosmetics used in and around the mouth. mercury and antimony are described below and impurity limits derived for other products are identified. acceptable oral intake of lead impurities in candy is 0. arsenic.Footnote4. however. In the US. Heavy metals The toxicological properties of lead.2. there is a limit for Footnote7 lead impurities of 10 ppm in products applied to the skin . For products licensed under the monograph stream of the Natural Health Product Regulations made under the Food and Drugs Act. cadmium. and it would not necessarily be appropriate for cosmetics to have a similar heavy metal impurity limit. These other impurity limits encompass a variety of products with exposure scenarios that may differ significantly from cosmetics. is outlined below.

3. Organic (methyl) mercury is of greater concern than inorganic mercury. however.4. 3.2. The Guidelines for Canadian Drinking Water Quality recommends a MAC of 0. The recommended MAC for arsenic in drinking water is 0. . or adverse effects on the nervous systemFootnote13.005 mg/L (0. Arsenic Arsenic exerts adverse effects due to a pronounced affinity for skin and keratinizing structures including the hair and nails. Clinical symptoms of overexposure to mercury include tremors. and dermal exposure can result in systemic toxicity. thus explaining the limited dermal absorption observed in vitroFootnote3. Carcinogenicity has been observed only in its inorganic formFootnote3.2.3. Various forms of mercury are toxic. Mercury The literature on the health effects of mercury is extensive.2. There is limited information on adverse effects following dermal exposure to ointments and creams that contain inorganic mercury compounds.3 µg/kg bw/day for arsenicFootnote11. 3. For the general population. symptoms of acute overexposure include a variety of skin eruptions. alopecia and characteristic striation of the nailsFootnote3. skin irritation. Arsenic does not act as a sensitizer. One study predicted that dermal exposure to arsenic may contribute less than 1% of the exposure from ingestionFootnote9. The United States Food and Drug Administration (US FDA) limit for arsenic in certain colorants is <3 ppmFootnote10. Mercury compounds may cause allergic reactions. due to poor skin penetrating ability of its naturally occurring compoundsFootnote3. The US EPA has an oral reference dose of 0. Metallic arsenic is not absorbed by the gastrointestinal tract and does not have any known adverse health effectsFootnote8.5%) and would be of concern only in situations where concentrated solutions would be in contact with the skin for several hours or longer. However. weakness. The health effects of arsenic in humans vary depending on the compound and form. Absorption of cadmium through the skin is low (0. Cadmium binds to epidermal keratin when applied topically.5 µg/kg bw/day for cadmiumFootnote12. The United States Environmental Protection Agency (US EPA) has established an oral reference dose (RfD) of 0.01 ppm) in CanadaFootnote8. The form of mercury plays a role in how much is absorbed via dermal or oral routes. the major route of mercury exposure is dietary intakeFootnote2.005 ppm) for cadmiumFootnote5. Cadmium Cadmium is classified as a human carcinogen by the National Institute for Occupational Safety and Health (NIOSH)Footnote3. Therefore. Most of the literature focuses on effects following inhalation exposure to metallic mercury vapours and oral exposure to inorganic and organic mercury compounds. significant dermal exposure as could occur in an occupational setting can cause irritant dermatitisFootnote3. all forms of mercury are absorbed through the skin and mucosaFootnote3. Dermal uptake is expected to be very limited. Inorganic arsenic compounds are more acutely toxic than environmentally occurring organic arsenic (for example dimethylarsinate).2.01 mg/L (0.

and the lack of well-conducted dermal absorption studies incorporating these factors. Antimony Overexposure to antimony and its compounds can adversely affect the skin. 3. primarily in food. The World Health Organization (WHO) has established a provisional tolerable daily intake of 2 µg/kg bw/day for total mercury and a provisional tolerable weekly intake of 1. impurity limits in cosmetics have not been developed for these metals.001 ppm) for mercuryFootnote5. selenium. determination of heavy metal limits in cosmetics based on human health risk alone is a challenge. provided that no other effective and safe preservative is availableFootnote13.6 µg/kg bw for methylmercuryFootnote15. mercury and antimony. The Guidelines for Canadian Drinking Water Quality recommend a MAC of 0. the general population is exposed to low levels. drinking water.006 mg/L (0. the amount of product applied.006 ppm) for antimonyFootnote5. 3. The US FDA limits mercury impurities in some colourants to <1 ppmFootnote10. . Because antimony is found naturally in the environment. arsenic.5.2. Health Canada has established a limit of 0. with the form of mercury typically determining the specific symptoms.5 ppm mercury in most commercial fishFootnote14. Dermal absorption of antimony has not been well studied. dermatitis and impaired kidney functionFootnote4. The Guidelines for Canadian Drinking Water Quality recommend a MAC of 0. 3.001 mg/L (0. children are more susceptible to heavy metal toxicity than adults and have greater exposure potential due to hand-to-mouth activity) the amount of product used the site of application (for example arms versus lips)   Assessment of dermal absorption by a single component in a cosmetic product is complex and depends on factors such as the concentration in the product. lungs. the length of time left on the skin and the presence of emollients and/or penetration enhancers in the cosmetic productFootnote18.3.2. Other metals Other metals (for example. Given this complexity. The WHO provisional tolerable daily intake for antimony is 6 µg/kg bw/dayFootnote17. cadmium. however the toxicological properties and corresponding risk associated with these substances are considered less significant than for lead. Considerations and approach to impurity limits for cosmetics Acceptable limits for heavy metals vary according to:  the subpopulation of interest (for example. and air. Accordingly. cardiovascular system and liver. Thimerosal is acceptable for use as a preservative in eye cosmetics in the US with a limit of 65 ppm. Average intake of individuals was estimated to be about 5 µg of antimony per dayFootnote16.6. barium and chromium) may be present as impurities in cosmetic products.memory loss.

comparison of conservative estimates of exposure to Canadians from use of cosmetics with the established tolerable intakes demonstrated that these levels provide a high level of protection to susceptible subpopulations of consumers (for example children).5 ppm In 2010. it was determined that heavy metal levels in cosmetic products above the values listed below are considered technically avoidableFootnote19:      Lead: 20 ppm Arsenic: 5 ppm Cadmium: 5 ppm Mercury: 1 ppm Antimony: 10 ppm In addition. the German government concluded that the recommended limits could be lowered. following a survey of its member companies. confirmed that heavy metal contents in toothpastes are at least a decimal power lower than for other cosmetic productsFootnote19. the German limits are based on levels that could be technically avoided. as evidenced by on-going monitoring of cosmeticsFootnote20. The German federal government conducted tests to determine background levels of heavy metal contents in toothpastes and other cosmetic products (note that in Canada. the Commission for Cosmetic Products at the federal Ministry of Health in Germany concluded that the following values are the maximum acceptable concentration for toothpastes:      Lead: 1 ppm Arsenic: 0.2 ppm Antimony: 0.There are currently no international standards for impurities in cosmetics. heavy metal impurities were limited to anything above normal background levels. Based on their studies. Therefore. as the Department has always maintained that impurities in cosmetics should be reduced to the extent that is technically feasible. the German Industrial Association for Personal Care and Detergents Inc. Health Canada has taken a similar approach in the establishment of heavy metal impurity limits. Thus.1 ppm Mercury: 0. Furthermore. Limits have been established in GermanyFootnote19. A review and analysis of the results of heavy metal testing conducted in the Health Canada Product Safety Laboratory on a number of cosmetics sold in Canada lead to the determination of limits in section 4 of this document. . most toothpastes are classified as natural health products).5 ppm Cadmium: 0. Rather than taking a risk-based approach.

caution is advised. Policy statement It is acknowledged that heavy metal impurities in cosmetic products are unavoidable due to the ubiquitous nature of these elements. Heavy metal impurity concentrations in cosmetic products are seen to be technically avoidable when they exceed the following limits:      Lead: 10 ppm Arsenic: 3 ppm Cadmium: 3 ppm Mercury: 3 ppm Antimony: 5 ppm These levels are based on cosmetic products sampled in Canada and are in line with acceptable levels of impurities in other program areas. but should be removed wherever technically feasible. Health Canada may request information on heavy metal test results for a cosmetic product if a risk is Responsibilities and requirements It is the manufacturer's responsibility to make sure that the finished cosmetic product contains as few heavy metal impurities as possible so that it does not exceed the limits set out above. manufacturers must ensure that products are safe and do not pose a risk to consumers. According to section 16 of the Food and Drugs Act. In addition. It is incumbent upon the individual to take the steps necessary to educate and protect themselves from unwanted side effects of mercury amalgam removal. When addressing the exposure from mercury fillings. Removal or replacement of mercury fillings should be performed by a dentist practicing safe procedures and protocols in mercury amalgam removal. It is strongly advised that one be under the guidance and supervision of a physician . 5. available at http://www. and the ingredients used in the manufacture of their products. It is important to note that occurrences of heavy metals above these limits will be evaluated on a caseby-case basis. comparison of exposure to Canadians from use of cosmetics and the established tolerable intakes for these metals demonstrated that these limits provide a high level of protection to susceptible subpopulations of consumers (for example children). It is therefore in the manufacturer=s best interest to have the information readily available. Products with values above these limits may undergo an assessment to determine the level of risk posed by the product. I have had many individuals come to me seeking medical assistance due to ill effects or worsening of a previous condition as a result of mercury exposure during unsafe amalgam removal. Manufacturers must make sure that their products. Health Canada will take action as deemed appropriate for products that contain heavy metals beyond the limits mentioned above.4. are of high quality. Refer to the International Association of Oral Medicine and Toxicology for complete guidelines.holisticmed. which would then determine the appropriate enforcement action.

http://www. there are several other pervasive toxic chemicals in our environment that are hazardous to our health and increase the risk of chronic disease.(MD or ND) who is trained and certified in the practice of chelation therapy (heavy metal detox) before commencing any procedure to remove or replace mercury fillings. Remember that there really are no “safe” levels of mercury or lead in the body. Research findings indicate that chelation therapy is an effective method of reducing total body burden of toxic metals. Encourage government bodies to implement more stringent policies to minimize entry of toxic chemicals and heavy metals into our http://rekalibrate. It is no longer our choice. Take measures to minimize or avoid common exposures of toxic chemicals for you and your family. We owe it to ourselves and to future generations of humans and wildlife to address the global health and environmental issues that are crucial to the survival of our planet.healthzone. stronger immune http://www.portmoodynaturopathic. resulting in improved physiological function. Implement daily practices to protect our environment so as not to contribute to the problem. it is our obligation. water and . Besides heavy metals. healthier aging and reduced occurrence of malignant diseases such as cancers and cardiovascular disease. but instead become part of the solution in helping to maintain the integrity of our ecosystem.