of Marijuana's Critical Medical Value in the Treatment of Conn's Syndrome (Primary Hyperaldosteronism).
By Anonymous Patient
Tumors on the adrenal gland are resistant to almost all blood pressure medications. and electrolyte balance. due to low blood pressure. excessive aldosterone is produced by one or more benign adrenal tumors. One of them is called spironolactone:
“The most common side effect of spironolactone is urinary frequency. which is also referred to as primary hyperaldosteronism. It is a hormone that plays an important role in maintaining blood volume. life-threatening disease caused by tumors on the adrenal gland. kidney failure. should be made aware of this information. and in females it can cause menstrual irregularities and breast tenderness and enlargement. only two medications are effective against this disease. when renin decreases. Other general side effects include ataxia. Its production is normally regulated by renin. it has been shown to be immunosuppressive in the treatment of sarcoidosis. which presents undeniable evidence of the medicinal value of Marijuana for the treatment of “Conn’s Syndrome”—a dangerous. testicular atrophy. and patients. body and muscle aches. When “active. Aldosterone is produced by the outer layer of the adrenal glands. Because it also affects the androgen receptors. It is a condition characterized by excessive secretion of aldosterone from the adrenal glands. dry skin. confusion. They are part of the endocrine system. and sexual dysfunction consisting of loss of libido and erectile dysfunction in males. a group of glands that produce and secrete hormones that act on and regulate many systems throughout the body.” these benign tumors cause uncontrollable. and both have serious side effects. or rarely. the cortex. by a cancerous adrenal tumor. Physicians. for unknown reasons (idiopathic). though a causal relationship between the two has not been established. Furthermore.” —E-Medicine
These tumors can also cause chronic fatigue.” —Lab Tests Online “Although initially considered a rarity. When renin increases. which does not respond to conventional blood pressure medications. With Conn’s syndrome. Almost everyone is aware about the dangerous effects of high blood pressure. aldosterone increases. and deadly high blood pressure. and numerous debilitating symptoms. Spironolactone may put patients at a heightened risk for bleeding from the stomach and duodenum. Also. and rashes. The adrenal glands are small triangular organs located on the top of the kidneys. it will lead to a stroke. pressure.
“Adrenal adenomas”—non-cancerous tumors on the adrenal gland—effect about 10 million people in the United States alone. And if the extreme high blood pressure is left untreated. and eventually death. frequent urination. known as “Conn’s syndrome”:
“Conn’s syndrome is the most common cause of secondary hypertension. decreased blood flow to the kidneys or to a sodium deficiency. aldosterone decreases. by hyperplasia. an enzyme produced in the kidneys.his report draws attention to a study conducted in Germany in 2008. These tumors are the cause of extremely high blood pressure. primary aldosteronism now is considered one of the more common causes of secondary hypertension (HTN). Since this is a life threatening illness. spironolactone can cause gynecomastia and feminization in general. heart attack. drowsiness.”—From Wikipedia
. In fact. this study proves Marijuana should not be listed among Schedule I drugs that have no medical value.
including chemotherapy. but in my view. which regulate and lower the production of the hormone that causes the high blood pressure. monitored his condition and treated him with conventional therapies. called a pheochromocytoma. this medication has not only controlled the symptoms of the pheochromocytoma." —From Wikipedia
Non-cancerous “adrenal adenomas” cause the same dangerous high blood pressure as the pheochromocytoma that threatened Steve Kubby’s life. dizziness. has arrested its growth.
The Endocannabinoid System
The following study reveals that endocannabinoids released by the body lower blood pressure. because it gives people a much better quality of life. "In some amazing fashion. However. Vincent DeQuattro. 1975 and 1976.”—From Wikipedia
These drugs have severe side effects. and therefore would be a life-saving medication to those who have Conn’s disease. altered renal function.
The Case of Steve Kubby
Former Libertarian Candidate Steve Kubby suffers from a cancerous adrenal tumor. to the amazement of his doctors:
“In 1968. His physician. Kubby’s blood pressure rose to astronomically dangerous levels. because Marijuana continues to be placed on Schedule I. fatal form of adrenal cancer. However. The partial text of this abstract also admits that Marijuana influences this same system. his medical records show that the cancer had metastasized to his liver and beyond. He has kept himself alive for more than 20 years by the use of medical marijuana. This last time. to the court’s amazement. All other patients with this diagnosis have had a 100% mortality rate within five years. by reducing the amount of aldosterone produced by the adrenal gland. an expert on this condition shocked to learn he was still alive. He was diagnosed with malignant pheochromocytoma. until referring him to the Mayo Clinic in 1981 for yet another surgery and radiation. hypotension.The second drug is called eplerenone:
“Common adverse drug reactions (ADRs) associated with the use of eplerenone include: hyperkalaemia. they watched as his blood pressure returned to normal levels. Yet the majority of doctors remain unaware of this alternative. Relevant portions will be highlighted. a rare. Marijuana is a superior alternative to these two medications. said. at the age of 23. a specialist from the USC School of Medicine. After being incarcerated for growing marijuana. Kubby claimed to control the symptoms of his disease solely by smoking medical marijuana and by maintaining a healthy diet. His original doctor.
. Mr. we will discover that marijuana has the same effect on the adrenal glands as endocannabinoids. he began experiencing symptoms of hypertension and palpitations. and doctors tell their patients they will die without them. Kubby underwent surgery to remove a tumor in 1968. For the next 25 years. Dr. after a judge ordered synthetic THC to be administered. and increased creatinine concentration.
G. the zona glomerulosa. particularly glucocorticoids. Two cannabinoid receptors. is secreted by the outer zone of the adrenal cortex. The response of the endocrine system to stress is characterized by activation of the sympathetic adrenomedullary system with increased epinephrine secretion and by HPA axis activation with hypersecretion of adrenocortical hormones. Argentina Abstract (Edited)
Endogenous cannabinoids are important signaling molecules in neuroendocrine control of homeostatic and reproductive functions including stress response and energy metabolism. CB1 receptors are widely distributed throughout the brain and affect memory. Appropriate regulatory control of the HPA axis is critical for health and survival.Expression and Function of Endocannabinoid Receptors in the Human Adrenal Cortex
Authors C. the endocannabinoid system at the level of the adrenal. M. W. It plays an important role in blood pressure adjustment by regulating salt-water homeostasis. 3]. Universidad de Buenos Aires(UBA). and prefrontal cortex. Endocannabinoids mimic some effects of marijuana by binding to cannabinoid receptors. Human adrenocortical NCI-H295R cells and normal human adrenal glands were used to study the possible effects of anandamide and cannabinoid receptor 1 (CB1) antagonist SR141716A on aldosterone and cortisol secretion. S. ligand binding properties and signal transduction systems. the body ’s most potent mineralocorticoid. Rettori. Krug. Germany 2 Centro de Estudios Farmacol ó gicos y Botá nicos. The highest densities of CB1 receptors are found in the basal ganglia. Ziegler. Ehrhart-Bornstein Affiliations 1 Carl Gustav Carus University Hospital. anandamide inhibited basal release and stimulated release of adrenocortical steroids (corticosterone and aldosterone). amygdala. Dresden. Department of Medicine III. R. Therefore. cerebellum. can directly influence adrenocortical steroidogenesis. C. such as the hippocampus. are involved in the integration of the HPA hormonal response [2. this effect was reversed by CB1 antagonist (SR141716A). Consejo Nacional de Investigaciones Cient í ficas y Técnicas. Bornstein. The endocannabinoid system (ECS) is a recently identified neuromodulatory system involved in several physiological and pathopysiological processes. hippocampus and dentate gyrus. CB2 was not expressed. Mohn. V. Aldosterone. A. Activation of the stress system leads to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chances for survival. which act as retrograde messengers to modulate the synaptic release of glutamate during stress response. and several limbic brain structures. pain perception and control of movement  . This study endeavors to elucidate possible interaction of the endocannabinoid system with the regulation of adrenocortical function at the adrenal level. The hypothalamic-pituitary-adrenal (HPA) axis is the major hormone system responsible for maintaining homeostatic balance in response to stressful stimuli. Buenos Aires. Furthermore. have been described with regard to their primary structure. The hypothalamic paraventricular and supraoptic nuclei have been shown to release endocannabinoids. CB1 and CB2. Our data indicate the expression of CB1 in human adrenal cortex and adrenocortical NCI-H295R cells. V. Lamounier-Zepter.
“ Endocannabinoids mimic some effects of marijuana by binding to cannabinoid receptors. Furthermore. This effect might. Furthermore. endocannaboids via CB1 receptors directly inhibit adrenocortical steroidogenesis at the level of the adrenal. Endocannabinoids reduce blood pressure by reducing aldosterone secretion at the level of the adrenal gland. CB2 receptors are found primarily in immune cells such as monocytes  . reproductive organs. however. and adrenal  . has not yet been studied. To date. be relevant in glucocorticoid homeostasis. Emerging evidence exists that the endocannabinoid system plays a role in endocrine regulation and energy balance including a modulation of HPA function  . Human adrenal cortex expressed predominantly CB1 receptors.
Previous studies focused on the interplay between the endocannabinoid system with the HPA axis at the central level. Our data indicate that. Until a few years ago. able to stimulate the HPA axis(for review ). Endocannabinoids mimic the effects of Marijuana. Mice lacking cannabinoid receptor type 1 (CB1. A possible direct effect on aldosterone secretion at the adrenal level. “Our data indicate that.
In conclusion. examines the expression of endocannabinoid receptors and possible effects of endocannabinoids on the release of cortisol and aldosterone in human adrenals and the human adrenocortical cell line NCI-H295R. endocannabinoids might. the CB1 receptor antagonist SR141716A has been shown to reduce blood pressure in obese patients. in addition to the central regulation of the HPA axis. the best-characterized endocannabinoids are arachidonoyl ethanolamine(anandamide. The present study. unknown whether endocannabinoids influence adrenal glucocorticoid synthesis directly at the level of the adrenal in addition to their central effects. It is. but are also present in the brain stem and glia . AEA) and 2-arachidonoylglycerol(2-AG) . Whereas the commonly accepted view attributes the cannabinoid system as having a general inhibitory role on neuroendocrine functions.”
The full abstract of this study can be found here.CB1 receptors are also found in amygdala and peripheral tissues such as spleen. in addition to a central influence of endocannabinoids on HPA axis function./ -) displayed a dysregulation of the HPA axis with a central impairment of glucocorticoid feedback and an enhanced circadian HPA axis activity peak resulting in elevated plasma corticosterone levels at the onset of dark [12 – 14] . the impact of cannabinoids on the HPA axis was considered to be an exception. endocannaboids via CB1 receptors directly inhibit adrenocortical steroidogenesis at the level of the adrenal. our data contributes further in vitro evidence for an interaction of the endocannabinoid system with adrenal steroidogenesis by inhibiting adrenal function directly at the level of the adrenal. in addition to the central regulation of the HPA axis. it has been suggested that cannabinoids are. tonsils.
. influence blood pressure regulation by reducing aldosterone secretion from the adrenal. therefore. on the contrary. it is suggested that this is primarily mediated by the weight-reducing effect of the antagonist (for review ).” 2. heart. in addition.
In this study we learned:
These data show that adrenocortical steroidogenesis within the human adrenal is directly influenced by the endocannabinoid system via CB1 receptors.
A Personal Story
By Anonymous Patient
For almost 20 years. Share this information with everyone!
I put this information together to save the lives of patients like myself. A CT scan revealed a tumor in my adrenal gland. they were convinced.
If undecided. leading to strokes. I have been living with a condition that should have taken my life. please read my story below. because I am drowning in debt. and untreated. I was admitted into Shady Grove hospital with cramps in my right side. Yet. it could help me get out of a bad situation. and also because I have a serious need. After sharing this information with my doctor. causing me to go in debt with several hospital visits. This tumor is the cause of my high blood pressure. heart attacks. please consider helping out. and kidney failure. it kills many people every year through uncontrollable high Blood pressure. and Endocrinologist. My blood pressure would rise to as high as 200/130. but medical marijuana has.Do You know someone with Conn’s Syndrome? Undetected. yet I am unable. If everyone who reads this only gives $1. I desperately need to move to a state friendly to medical marijuana. a drug the United States Government says has no medicinal value could save their lives.
Please help those who could die of this disease.
If you have found this information useful. About two years ago. No blood pressure medication would keep my pressure down.