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N. Campbell-McBride, M.D. In his seminal book, Good Calories, Bad lems in children and adults are becoming Calories, Gary Taubes quotes Hilde Bruch more and more common. who wrote: "The literature on obesity is not In clinical practice these conditions only voluminous, it is alsofallofcoriflicting overlap with each other. A patient wdth and confasing reports and opinions. One autism often is hyperactive and dyspraxic. might well add to this the words ofArtemus There is about 50% overlap between dysWard: "The researches ofso many eminent lexia and dyspraxia and 25-50% overlap between ADHD/ADD and dyslexia and scientific men have thrown so much darkness on the subject that if they continue these dyspraxia. Children with these conditions researches we shall soon know nothing. " are often diagnosed as being depressed, Determining the causes ofthe hundreds and as they grow up they are more prone ofpsychiatric disorders and their treatment to drug abuse or alcoholism than their has almost reached that state oftotal dark- typically developing peers. A young perness. Dr. Campbell-McBride, in her bookson diagnosed with schizophrenia often Gut and Psychology Syndrome, blows away suffered from dyslexia, dyspraxia or/and some ofthefog and shows us where to look. ADHD/ADD in childhood. When we After I read it, I wrote to the author: "Had start examining the patients with these I read your excellent book forty years ago I so-called mental conditions, we find that would have thought you were nuts. Thirty they are also physically ill. Digestive probyears ago I would have seen some merit and lems, allergies, eczema, asthma, various in the last years what I have learned has food intolerances and immune system confirmed whatyou have written. It is a veryabnormalities are universally present good book. Isn't it a shame that psychiatric amongst them. We have created different illnesses arefueled by foods and the way we diagnostic boxes for these patients, but deal with them. Ironically, psychiatry may a modern patient does not fit into any never accept this idea, as it has become the one of them neatly. The modern patient unpaid servant of the drug industry. Many in most cases fits into a rather lumpy picture of overlapping neurological and thanks for sending it to me. " To learn more, please read the book by psychiatric conditions. Why are all these conditions related? Dr. Natasha Campbell-McBride, Gut and What underlying problem are we missing? PsychologySyndrome:NaturalTreatmentfor To answer all these questions we have Autism, ADHD/ADD, Dyslexia, Dyspraxia, to look at one factor, which unites all these Depression, Schizophrenia. patients in a clinical setting. This factor -Ahram Hoffer, MD, PhD is the state of their digestive system. I have yet to meet a child or an adult with We live in the world of unfolding autism, ADHD/ADD, dyspraxia, dyslexia, epidemics. Autistic Spectrum Disorders, schizophrenia, bipolar disorder, depresAttention Deficit Hyperactivity Disorder sion or obsessive-compulsive disorder (ADHD/ADD), schizophrenia, dyslexia, who does not have digestive abnormalidyspraxia, depression, obsessive -compul- ties. In many cases they are severe enough sive disorder, bipolar disorder and other for the patients or their parents to start neuro-psychological and psychiatric prob- talking about them first. In some cases the parents may not mention their child's digestive system, yet when asked direct *GAP Syndrome or GAPS™'
So. The first and very important function is appropriate digestion and absorption of food. They coat the entire . Apart from normal digestion and absorption of food. Not many people know that an adult on average carries 2 kg of bacteria in the gut. what have digestive abnormalities got to do with these so-called mental problems? According to recent research and clinical experience . testing reveals some typical nutritional deficiencies in many important minerals. essential fats. What is a typical scenario we see in clinical practice? Before examining the patient it is very important to look at the health history of the parents. many amino acids and other nutrients. And that is what we commonly see in children and adults with learning disabilities. It is a highly organized micro-world.then the child will not digest and absorb foods properly. a typical health picture of these children's mums has emerged: due to various modern factors a modern mum has seriously compromised gut flora by the time she is ready to have children. pyridoxine (vitamin Be). which will have a tremendous effect on this child's health for the rest 91 of his/her life. Indeed. A baby is born with a sterile gut. Fathers with abnormal gut flora contribute to the bodily flora of the mother and through her to the gut flora of the child. mother in particular. cyancobalamin (vitamin B12). beneficial bacteria in the gut act as the housekeepers for the digestive tract. Whatever microbiai flora the mother has. developing multiple nutritional deficiencies. Apart from taking a vital part in nourishing the body. apart from genetics there is something very important the parents. This is the child's gut flora. The Role and Importance ofthe Gut Flora Gut flora is something we do not think much about. vitamins. After studying hundreds of cases of neurological and psychiatric conditions in children and adults. where certain species of bacteria have to predominate to keep us healthy physically and mentally. And yet the number of functions the gut flora fulfils is so vital for us that if some day our digestive tracts were sterilised we probably would not survive.the parents. Even in the cases where the child may grow well. If a child does not acquire normal balanced gutflora. people with gut dysbiosis present with deficiencies of these nutrients. healthy gutfloraactively synthesizes various nutrients: vitamin K. when tested. In the first 20 or so days of life the baby's virgin gut surface is populated by a mixture of microbes. Whenever the parents are mentioned people immediately think about genetics. Their role in our health is so monumental.Gut and Psychology Syndrome questions. pass to their child: their unique gut micro-flora. psychiatric problems and allergies. Many of these patients are malnourished. There are more cells in that microbiai mass than there are cells in an entire human body. riboflavin (vitamin B2). We will talk in detail about the child's gut flora later.a lot! In fact it appears that the patient's digestive system holds the key to the patient's mental state. folie acid. thiamine (vitamin Bi). Clinical experience shows that restoring the beneficial bacteria in their gut is the best way to deal with these deficiencies. various amino-acids and proteins. that we simply cannot afford to ignore them. Indeed. would describe a plethora of gut problems. Now let us come back to the source of the child's gut flora . Where does this gut flora come from? Mainly from the mother at the time of birth. clinical signs of gut dysbiosis (abnormal gut flora) are present in almost 100% of mothers of children with neurological and psychiatric conditions. pantothenic acid. she passes to her newborn child. niacin (vitamin B3). However.
The most common autoantibodies found are to myelin basic protein (MBP) and neuron-axon filament protein (NAFP). Housing a mass of pathogenic microbes the gut cannot be healthy. As a result. infantile colic and abdominal pain. Thefloramay have been damaged further by repeated courses of antibiotics and vaccinations. Lack of beneficial bacteria would allow disease-causing microbes to grow and occupy large parts of the digestive system causing damage and inflammation in the gut wall. asthma and eczema . causing different neurological and psychiatric symptoms. which children and adults with neurological and psychiatric conditions commonly suffer from. These pathogenic microbes start digesting food in their own way producing large amounts of various toxic substances. The research shows deep abnormalities in all major cell groups and immunoglobulins. So. However. The Role and Importance ofthe Immune System A baby is born with an immature immune system. 2008 surface of the gut protecting it from invaders and toxins by providing a natural barrier and producing anti-bacterial. No. There has been a considerable amount of research published into the state ofthe immune system in patients with learning disabilities and psychiatric problems. which are most commonly found on testing.Journal of Orthomolecular Medicine Vol. Indeed. long before these patients develop so-called mental symptoms they usually suffer from digestive problems and all other typical sjmiptoms of gut dysbiosis pretty much from the start of their lives. Indeed most patients with learning disabilities. Due to the absence or greatly reduced numbers of beneficial bacteria in the 92 . carried to the brain and cross the blood-brain barrier. Two particular groups. reflux and indigestion. Examination by gastroenterologists commonly reveals inflammatory process in the gut and many of these patients are diagnosed with coeliac disease. viruses and fungi have a good chance to occupy large territories in the digestive tract and grow large colonies. immunoglobulins. are yeasts (including Candida species) and the Clostridia family. allergies. in children and adults who go on to develop neurological and psychiatric problems. psychiatric disorders and allergies present with digestive problems: constipation and diarrhoea.symptoms. The beneficial bacteria in the gut ensure appropriate production of different immune cells. these children commonly suffer from digestive problems. Without control ofthe beneficial bacteria. Damage inflicted upon the gutfloratypically leads to an imbalance between major parts of immunity. resulting in allergies. asthma and eczema. 2. bloating and flatulence. 23. which are absorbed into the blood stream. To summarize: A child born from parents with abnormal gut flora did not acquire normal gut flora from the start. Beneficial bacteria normally control various opportunistic and pathogenic microbes in the gut. These antibodies specifically attack the person's brain and the rest ofthe nervous system. which damage the child's gut flora and immune system even further. anti-viral and anti-fungal substances. different opportunistic and pathogenic bacteria. the digestive tract itself cannot be healthy. keeping immunity in the right balance. it is no surprise when the gut flora is abnormal. The result is lots of infections followed by lots of courses of antibiotics. At the same time they provide the gut lining with nourishment. If the baby acquires compromised gut flora from the mother then the baby is left immune compromised. Establishment of healthy balanced gut flora in the first few days of life plays a crucial role in appropriate maturation of the immune system. The number and mixture of toxins can be very individual. something even worse happens.
These are the patients who fall through the gap in our medical knowledge. et al: Colonie CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. bipolar disorder. 16. Anthony A. Digest Diseas Sei. the more we realize just how right they were. Rabsztyn A et al: Gastrointestinal abnormalities in children with autism./Pedi'atr. asthma and eczema in any possible combination. Medicina. Bolte ER: Autism and Clostridium tetani. 1978. Horrobin DF.New aspects of probiotics . concluded in 1807: "The primary seat of insanity generally is in the region of the stomach and intestines. Apostolov E. 136:1306-1309. BritJPsychiat. Papadimitriou JC. Re-establishing normal gut flora and treating the digestive system of the person has to be the number one treatment for these disorders. ADD. schizophrenia. 17: 585. 1989. 17. 385-399. 1966. Encéphale. 13. ISBN 0 -7499 -2213 -3. The mixture of toxicity in each child or adult can be quite individual and different. 15. 53: 525-529. 2001. dyslexia. 1997. 1998. 18. Ferrari P et al: Immune status in infantile autism: Correlation between the immune status. Absolon CM at al: Psychological disturbance in atopic eczema: the extent of the problem in school-aged children. 3. The GAPS children and adults can present with symptoms of autism. That is why it is logical to group these disorders under one name: the Gut and Psychology Syndrome (GAPS)3. Salminen SS. 14.//luíis/n Develop Disord. Any child or adult with a learning disability. 7.138: 366-72. But what they all have in common is gut dysbiosis (abnormal gutflora). Br J Dematol. OCD. This connection has been known by medics for a very long time. 8. 9. 2. 4. neurological or psychological problems and allergies should be thoroughly examined for gut dysbiosis. 2000. 18: 195-207. Dohan FC: Is celiac disease a clue to pathogenesis of schizophrenia? Mental Hygiene. 1984:19(3). Biological Basis of Schizophrenia. 1994. 2003. Glen AM. 1979. Dohan CF: Cereals and schizophrenia: data and hypothesis. 1987./leía Psyc/íí'aíScawd. 45: 723-729. allergies. 6. Lancaster MTP Press. Med Hypoth. 1969. Takayuki M. Dohan CF et al: Relapsed schizophrenics: more rapid improvement on a milk and cereal free diet. 1999. The father of modern psychiatry French psychiatrist Phillipe Pinel (1745-1828). 14: 339-344. which is produced by the abnormal microbiai mass in these patients. Horvath K. dyspraxia. 10. 42: 125-152. Ashkenazi et al: Immunologie reaction in psychotic patients to fractions of gluten. 5. Krasnogolovez VN: Colonie disbacteriosis. 135: 559-563. ADHD. autistic symptoms and levels of serotonin. Am J Psychiatry. Kirjavainen PV. 3. Schiz Res. 51(2): 133-144.The toxicity. 1969. 2000. Vaddadi K: The membrane hypothesis of schizophrenia. 137(2): 24105. sleep disorders. Kashiwagi Y et al: Detection and sequencing of measles virus from peripheral blood mononuclear cells from patients with inflammatory bowel disease and autism. the person's digestive system instead of being a source of nourishment becomes a major source of toxicity in the body. Kawashima H. Kontstanareas M. Furlano RI. Homatidis S: Ear infections in autistic and normal children. Dohan et al: Is schizophrenia rare if grain is rare? Biol Psychiat. 11. after working with mental patients for many years. 93 References 1. 12." Long before him Hippocrates (460-370 BC). Isolauri E: 1999. Baruk H: Psychoses of digestive origins. before considering any other treatments with drugs or otherwise. 1988. establishes a link between the gut and the brain. In: Hemmings and Hemmings (eds). Holford P: Optimum Nutrition for the Mind. the father of modern medicine has said: "All diseases begin in the gut!" The more we learn with our modern scientiflc tools. depression. Cade R et al: Autism and schizophrenia: intestinal disorders. 115: 595-596. Nutri Neurosci.a novel approach in the management of food . Day R.Gut and Psychology Syndrome gut flora. / Pediatr. Gut And Psychology Syndrome (GAP Syndrome or GAPS) establishes the connection between the state of the patient's gut and the functioning of the brain.
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