DEZVOLTAREA SISTEMULUI NERVOS

Stadiile Carnegie pentru dezvoltarea embrionară umană

După st. C. 23: fetus

Fecundaţia

Fecundaţia

Mayer W, Smith A, Fundele R, Haaf T. (2000) Spatial separation of parental genomes in preimplantation mouse embryos. J Cell Biol. 2000 Feb 21;148(4):629-34.

Formarea morulei .

formarea blastocistului şi nidarea .Fecundaţia.

Formarea blastocistului şi nidarea .

Formarea blastocistului şi nidarea .

Formarea blastocistului şi nidarea 13-15 zile .

.

.

Formarea blastocistului şi nidarea St. C. 7 (15-17 zile) .

Discul embrionar şi şanţul primitiv .

Neurulaţia .

corpul şi membrele . a primordiului cardiac şi şanţului neural: 19-21 zile (1-3 somite) • încheierea neurulaţiei: 22-23 zile (12 somite) • închiderea neuroporului rostral: 23-23 zile (13-20 somite) • închiderea neuroporului caudal: 26-30 zile (21-29 somite) • apar mugurii picioarelor: 28-32 zile (30 somite) • începe osificarea: 44-48 zile • se disting capul rotund.REPERELE MORFOLOGICE ALE STADIILOR EMBRIONARE (toate duratele sunt exprimate în zile gestaţionale trecute de la fecundaţie) • nidarea: 7-12 zile • apariţia şanţului primitiv: 13-15 zile • gastrulaţia şi apariţia notocordului: 15-17 zile • apariţia curburii cefalice.

C. Science 291.. Venter et al. 1304 -1351 (2001) .Published by AAAS J.

Factori de transcripţie .

Molecule de semnalizare .

.

.

.

.

.

Sindrom Waardenburg Aniridia .

.

.

is = isthmus. . and Emx-2 in the hindbrain. LV = lateral ventricle. PT = pretectum. 1 Schematic diagram of embryonic brain organization showing the principal expression domains of Hoxb-1.Fig. The expression domains respect boundaries that delineate the transverse and longitudinal subdivisions of the central nervous system. sc = spinal cord. Emx-1. and cerebral cortex. ME = mesencephalon. r1–7 = rhombomeric subdivisions. VT = ventral thalamus. Dlx-2. ventral thalamus and basal ganglia. p1–6 = prosomeric subdivisions. CB = cerebellum. MGE = medial ganglionic eminence. Dlx-1. DT = dorsal thalamus. LGE = lateral ganglionic eminence. respectively.

chicken (H 2195) .Chick. whole mount. 60-70hour .

.

.

.

.

.

.

000 connections with other neurons. The postnatal development of the human cerebral cortex.Golgi-stained sections of human cerebral cortex taken from equivalent areas of the anterior portion of the middle frontal gyrus at different ages. Note that there is a tremendous increase in the complexity of dendritic aborizations with increasing age. Cambridge. Each one of these neurons will make up to 10. . JL. This maturational process is going on at the same time children are usually exposed to the highest levels of lead paint dust by virtue of their normal hand-tomouth behavior.000 miles of axons and dendrites in the human cerebral cortex. 1959. Ref: Conel. Mass: Harvard University Press. There are 30 billion neurons and 62.

.

.

.

.

Corbin. | doi:10.1038/nn749 Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain Joshua G. 1177 . Susana Nery & Gord Fishell Figure 2. 1 to broadly depict the major routes of cell migration in the developing telencephalon.1182 (2001) Published online: . Key to migratory routes: (1) MGE to the dorsal telencephalon (2) CGE to dorsal telencephalon (3) Cortical-striatal boundary to the ventrolateral telencephalon (lateral cortical stream) (4) LGE to the olfactory bulb (rostral migratory stream).Nature Neuroscience 4. . Major routes of tangential migration. The question mark on arrow (2) indicates that this route is less well characterized than the others. Numbered arrows are superimposed on Fig.

.

.

.

.

.

.

.

.

.

.

.

.Gataaa..? .