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1: J Natl Cancer Inst. 1992 Jan 1;84(1):47-51.

Effect of vitamin A, C, and E supplementation on rectal cell proliferation in patients with Related Articles
colorectal adenomas.
Calcium and colorectal epithelial cell proliferation in sporadic
adenoma patients: a randomized, double-blinded, [J Natl Cancer Inst.1995]
Paganelli GM, Biasco G, Brandi G, Santucci R, Gizzi G, Villani V, Cianci M, Miglioli M,
Barbara L. Effects of calcium and vitamin supplementation on colon cell
proliferation in colorectal cancer. [CancerInvest.2000]
Istituto di Clinica Medica e Gastroenterologia, University of Bologna, Italy.
Effects of dietary wheat bran fiber on rectal epithelial cell
Studies suggest that cell proliferation abnormalities of the colorectal mucosa are associated with [J Natl Cancer
proliferation in patients with resection for colorectal Inst.1990]
risk of neoplasia, and most cancers of the large bowel are thought to arise from adenomas. The Review Reliability of rectal epithelial kinetic patterns as an
results of other studies suggest that vitamins A, C, and E have chemopreventive efficacy against intermediate biomarker of colon cancer. [JCellBiochemSuppl.1994]
colon cancer in animal models. This study evaluates the effect of dietary vitamin
Review Methodological problems in the use of rectal cell
supplementation on cell kinetics in uninvolved rectal mucosa in patients with colorectal proliferation as a biomarker of colorectal cancer
adenomas. Twenty patients with colorectal adenomas were given vitamins A, C, and E for 6
months after complete polypectomy, and 21 patients with adenomas received placebo. In each » See Reviews... | » See All...
patient, six biopsy specimens were taken from normal-appearing rectal mucosa before
treatment and after 3 and 6 months of treatment and were incubated with tritiated thymidine
Cited by PubMed Central articles
([3H]thymidine), and the [3H]thymidine-labeled cells were counted by use of autoradiography.
Two parameters of cell proliferation were evaluated: 1) the ratio of the number of labeled cells Review Chemoprevention of colorectal cancer.
to the total number of cells (thymidine labeling index) and 2) the ratio of the number of labeled [Gut.1998]
cells in the upper 40% of the crypt to the total number of labeled cells in the crypt (phi h). The
latter index reflects abnormal expansion of the proliferative compartment and is thought to be Review Colon cancer: polyps, prevention, and politics.
an intermediate biomarker of cancer risk. In patients receiving vitamins, phi h decreased [TransAm ClinClimatolAssoc .1998]
progressively from baseline values, with increasing statistical significance (P less than .05 after 3 Rectal epithelial cell proliferation patterns as predictors of
months, P less than .01 after 6 months). There was a statistically significant decrease in the adenomatous colorectal polyp recurrence. [Gut.1993]
thymidine labeling index in the 40% of the crypt near the mucosal surface, but the variation in » See all (4)...
the overall labeling index was not statistically significant. In the placebo group, we observed no
statistically significant change in cell kinetics. These findings suggest that vitamin A, C, and E
Patient Drug Information
supplementation is effective in reducing abnormalities in cell kinetics that may indicate a
precancerous condition. Before larger trials on chemoprevention of colorectal adenoma Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...)
recurrence are conducted, additional studies are needed (a) to validate that cell kinetics is an Ascorbic acid is used to prevent and treat scurvy, a disease
intermediate biomarker, (b) to determine active agents, optimal dosage, and the relative caused by a lack of vitamin C in the body.
efficacy of agents given alone and in combination, and (c) to test toxicity.
Source: AHFS Consumer Medication Information
PMID: 1738173 [PubMed - indexed for MEDLINE]
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