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Inheritance  and  Pedigrees  

Complete complement of an organism’s DNA.     Image: Chromosome & gene. National Human Genome Research Institute From the Virtual Cell Biology Classroom on ScienceProfOnline.Genetics Terminology: Chromosomes & Genes •  Genome .com . Graham Colm. •  Cellular DNA is organized in Chromosmes •  Genes have specific places on chromosomes.

Law of Segregation 3. From the Virtual Cell Biology Classroom on ScienceProfOnline. Mendel's Principles of Heredity: A Defense by Bateson.(Johann)  Gregor  Mendel  (1822-­‐1864)  •Austrian  monk   who  discovered  basic  principles  of  heredity  through   his  experiments  with  garden  peas  Received  no   recogniGon  for  his  work  during  his  lifeGme   Mendel's Laws 1.com . Law of Independent Assortment Image: Gregor Mendel. Law of Dominance 2. William.

Mendels Law of Segregation . .Alleles for a trait are then "recombined" at fertilization. only one form of the trait will appear in the next generation.Mendels Law of Dominance In a cross of parents that are pure for contrasting traits. Mendels Law of Independent Assortment .  Offspring that are hybrid for a trait will have only the dominant trait in the phenotype.  .Alleles for different traits are distributed to sex cells (& offspring) independently of one another.During the formation of gametes (eggs or sperm). producing the genotype for the traits of the offspring. the two alleles (hereditary units) responsible for a trait separate from each other.

What  is  Mendelian  Inheritance?   Mendelian  Inheritance  refers  to  the  transmission  of  inherited  traits  from   generaGon  to  generaGon  through  the  transmission  of  genes     Autosomal  Recessive   Autosomal  Dominant   X-­‐linked  recessive   X-­‐linked  dominant   Y-­‐linked   Mitochondrial   Defini=on  of  terms:  see  notes   .

___________ genotype: At least one dominant allele is present (R-). Harry: Being able to roll your tongue is the dominant trait (phenotype). Character: Tongue Rolling Being able to roll your tongue is a dominant phenotype. Q: What would be the recessive genotype? ___  ___   ___  ___   ___  ___   Q: Would “Harriet” be able to roll her tongue? From the Virtual Cell Biology Classroom on ScienceProfOnline.Genetics Terminology     Dominant & Recessive Genotypes & Phenotypes ____________ genotype: Both recessive alleles must be present (rr).com . Q: How would we represent the genotype of he was homozygous dominant? Hermione: Not being able to roll your tongue is the recessive (phenotype).

 The   autosomal  dominant  faulty  gene  copy   is  represented  by  ‘D’.  the  working  copy  of   the  gene  by  ‘d’.   .  The   autosomal  dominant  faulty  gene  copy  is   represented  by  ‘D’.Autosomal  dominant  inheritance  when   one  parent  carries  the  autosomal   dominant  faulty  gene  copy.  the  working  copy   of  the  gene  by  ‘d’.   Autosomal  dominant  inheritance  when   both  parents  carry  the  autosomal   dominant  faulty  gene  copy.

Autosomal  dominant  inheritance   Parents   Gametes   .

Autosomal  dominant  inheritance   Parents   Gametes   At   conception   .

Autosomal  dominant  inheritance   Parents   Gametes   At   conception   .

Autosomal  dominant  inheritance   Parents   Gametes   At   conception   .

Autosomal  dominant  inheritance   Parents   Gametes   At   conception   .

Autosomal  dominant  inheritance   Parents   Gametes   At   conception   Affected   Affected   Unaffected   .

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Autosomal  recessive  inheritance  when   both  parents  are  unaffected  gene=c   carriers  for  the  condi=on.  The  faulty   copy  of  the  gene  containing  a  recessive   muta=on  is  represented  by  ‘r’.   the  working  copy  of  the  gene  by  ‘R’     .  The   faulty  copy  of  the  gene  containing  a   recessive  muta=on  is  represented  by  ‘r’.     Autosomal  recessive  inheritance  when   only  one  of  the  parents  is  an  unaffected   gene=c  carrier  for  the  condi=on.  the   working  copy  of  the  gene  by  ‘R’.

  the  working  copy  of  the  gene  by  ‘R’.Autosomal  recessive  inheritance  when   one  of  the  parents  is  an  affected  or   predisposed  to  develop  the  condi6on.     .  The  faulty  copy   of  the  gene  containing  a  recessive   muta6on  is  represented  by  ‘r’.  The   faulty  copy  of  the  gene  containing  a   recessive  muta6on  is  represented  by  ‘r’.  the   working  copy  of  the  gene  by  ‘R’.   and  the  other  parent  is  an  unaffected   gene6c  carrier  for  the  condi6on.     Autosomal  recessive  inheritance  when   both  parents  are  affected  or  predisposed   to  develop  the  condi6on.